5-Chloro-1,3-xylene supplier

Name
5-Chloro-1,3-xylene
EINECS
CAS No. 556-97-8
Article Data10
CAS DataBase
Density 1,04 g/cm3
Solubility
Melting Point -41.95°C (estimate)
Formula C8H9 Cl
Boiling Point 188.1 ºC at 760 mmHg
Molecular Weight 140.612
Flash Point 63.1 ºC
Transport Information
Appearance liquid
Safety Experimental reproductive effects. When heated to decomposition it emits toxic fumes of Cl⁻.
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms m-Xylene,5-chloro- (8CI); 1-Chloro-3,5-dimethylbenzene; 3,5-Dimethylchlorobenzene;3,5-Dimethylphenyl chloride; 3-Methyl-5-chlorotoluene;5-Chloro-1,3-dimethylbenzene; 5-Chloro-m-xylene; 5-Chloro-m-xylene
PSA 0.00000
LogP 2.95680

Synthetic route

: <(3,5-Dimethylphenyl)azo>pyrrolidine

: 556-97-8
1-chloro-3,5-dimethylbenzene

Conditions

Conditions	Yield
With hydrogenchloride; copper(l) chloride	54%
With hydrogenchloride; copper(l) chloride Product distribution; triazene moiety as protecting group for aromatic amines; var. triazenes;

: 108-69-0
3,5-dimethylaminoaniline

: 556-97-8
1-chloro-3,5-dimethylbenzene

Conditions

Conditions	Yield
With hydrogenchloride Diazotization.Behandlung der Diazoniumsalz-Loesung mit CuCl;

dibromide of 5-chloro-1.3-dimethyl-cyclohexadiene: dibromide of 5-chloro-1.3-dimethyl-cyclohexadiene

: 556-97-8
1-chloro-3,5-dimethylbenzene

Conditions

Conditions	Yield
With quinoline

: 95-47-6
o-xylene

A: 95-66-9
2,4-dimethylchlorobenzene

B: 556-97-8
1-chloro-3,5-dimethylbenzene

C: 95-72-7
2-chloro-1,4-dimethyl-benzene

D: 6781-98-2
2,6-dimethyl-1-chlorobenzene

E: 615-60-1
4-chloro-1,2-dimethylbenzene

F: 608-23-1
3-chloro-o-xylene

G: 20824-80-0
1,2-dichloro-4,5-dimethyl-benzene

H: 68266-67-1
1,2-dichloro-3,4-dimethyl-benzene

I: 34060-72-5
2-methyl-5-chlorobenzyl chloride

J: 52331-02-9
1,4-dichloro-2,3-dimethyl-benzene

K: 70172-92-8
3,5-dichloro-o-xylene

L: 552-45-4
1-chloromethyl-2-methylbenzene

M: 55676-90-9
alpha,2-dichloro-6-methyltoluene

Conditions

Conditions	Yield
With chlorine; the fluorine-containing K-L-type zeolite In 1,2-dichloro-ethane at 80℃; for 1.75 - 3.66667h; Product distribution / selectivity;
With chlorine; a K-L-type zeolite In 1,4-dioxane; 1,2-dichloro-ethane at 80℃; for 6.75h;

...Expand

: 7758-89-6
copper(I) chloride

: 108-69-0
3,5-dimethylaminoaniline

: 556-97-8
1-chloro-3,5-dimethylbenzene

Conditions

Conditions	Yield
With hydrogenchloride; sodium nitrite In water

: 556-97-8
1-chloro-3,5-dimethylbenzene

A: 17057-88-4
3,5-dimethylbiphenyl

B: 98-80-6
phenylboronic acid

Conditions

Conditions	Yield
With cesium fluoride; Pd(dba)2 In toluene	A n/a B 99%

: 556-97-8
1-chloro-3,5-dimethylbenzene

: 108-69-0
3,5-dimethylaminoaniline

Conditions

Conditions	Yield
With ammonium hydroxide; potassium phosphate In dimethyl sulfoxide at 80℃; UV-irradiation;	99%
Multi-step reaction with 2 steps 1.1: sulfuric acid; nitric acid / 30 °C / Cooling with ice 2.1: palladium on activated charcoal / ethanol / 0.5 h / 50 °C / Autoclave 2.2: 0.83 h / 65 °C / 2250.23 Torr / Autoclave View Scheme

: 556-97-8
1-chloro-3,5-dimethylbenzene

: 100-46-9
benzylamine

: 124043-95-4
N-benzyl-3,5-dimethylaniline

Conditions

Conditions	Yield
With potassium phosphate In dimethyl sulfoxide at 80℃; UV-irradiation;	99%

: 556-97-8
1-chloro-3,5-dimethylbenzene

: 98-80-6
phenylboronic acid

: 17057-88-4
3,5-dimethylbiphenyl

Conditions

Conditions	Yield
With cesium fluoride; Pd(dba)2 In toluene	98%
With potassium phosphate; C75H58Cl2N4Pd In water; isopropyl alcohol at 25℃; for 4.5h; Reagent/catalyst; Suzuki-Miyaura Coupling; Schlenk technique;	98%
With potassium phosphate; C20H28Br2N2Pd In water; isopropyl alcohol at 25℃; for 7.5h; Reagent/catalyst; Suzuki-Miyaura Coupling;	95%

: 556-97-8
1-chloro-3,5-dimethylbenzene

: 2835-99-6
4-amino-3-methylphenol

: 1198117-98-4
4-(3,5-dimethylphenylamino)-3-methyl-phenol

Conditions

Conditions	Yield
With chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2',4',6'-triisopropyl-1,1'-biphenyl][2-(2-aminoethyl)phenyl]palladium(ll); sodium t-butanolate In 1,4-dioxane at 110℃; for 3h; Inert atmosphere;	97%

: 617-89-0
furan-2-ylmethanamine

: 556-97-8
1-chloro-3,5-dimethylbenzene

: 416887-98-4
N-(furan-2-yl-methyl)-3,5-dimethylaniline

Conditions

Conditions	Yield
With potassium phosphate In dimethyl sulfoxide at 80℃; UV-irradiation;	97%

: 556-97-8
1-chloro-3,5-dimethylbenzene

: 36343-05-2
N-methylheptylamine

: (3,5-dimethyl-phenyl)-heptyl-methyl-amine

Conditions

Conditions	Yield
With sodium t-butanolate; 3-dioxolane; Pd(dba)2*2-(2'-dicyclohexylphosphinophenyl)-2-methyl-1 In toluene at 105℃; for 1h;	95%

: 556-97-8
1-chloro-3,5-dimethylbenzene

: 2835-96-3
4-amino-2-methylphenol

: 1198117-78-0
4-[(3,5-dimethylphenyl)amino]-2-methylphenol

Conditions

Conditions	Yield
With chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2',4',6'-triisopropyl-1,1'-biphenyl][2-(2-aminoethyl)phenyl]palladium(ll); sodium t-butanolate In 1,4-dioxane at 110℃; for 1.33333h; Inert atmosphere;	94%

: 78-59-1
3,5,5-Trimethylcyclohex-2-en-1-one

: 556-97-8
1-chloro-3,5-dimethylbenzene

: 3-(3,5-dimethylbenzyl)-5,5-dimethylcyclohex-2-enone

Conditions

Conditions	Yield
With 2-(2,6-dimethoxyphenyl)-1-methyl-3-(diphenylphosphino)-1H-indole; palladium diacetate; lithium tert-butoxide In 1,4-dioxane at 100℃; for 1h; Schlenk technique; Inert atmosphere;	94%

: 110-91-8
morpholine

: 556-97-8
1-chloro-3,5-dimethylbenzene

: 16800-77-4
N (dimethyl-3,5-phenyl-1) morpholine

Conditions

Conditions	Yield
With sodium t-butanolate; 3-dioxolane; Pd(dba)2*2-(2'-dicyclohexylphosphinophenyl)-2-methyl-1 In toluene at 105℃; for 1h;	92%

: 556-97-8
1-chloro-3,5-dimethylbenzene

: 960-16-7
tributylphenylstannane

: 17057-88-4
3,5-dimethylbiphenyl

Conditions

Conditions	Yield
With potassium fluoride; tetrabutylammomium bromide; tris-(o-tolyl)phosphine; copper(I) oxide at 125 - 130℃; for 72h; Stille cross-coupling;	92%
With palladium diacetate; orotic acid; cesium fluoride In 1,4-dioxane at 100℃; for 22h; Stille Cross Coupling; Sealed tube; Inert atmosphere; Schlenk technique;	44%

: 556-97-8
1-chloro-3,5-dimethylbenzene

: 13105-53-8
butylcarbamic acid benzyl ester

: 1198294-06-2
benzyl butyl(3,5-dimethylphenyl)carbamate

Conditions

Conditions	Yield
With bis(η3-allyl-μ-chloropalladium(II)); bis(3,5-bis(trifluoromethyl)phenyl)(2’,4’,6’-triisopropyl-3,6-dimethoxy-[1,1’-biphenyl]-2-yl)phosphine; caesium carbonate In toluene at 130℃; for 17h; Inert atmosphere; Molecular sieve;	92%

: 556-97-8
1-chloro-3,5-dimethylbenzene

: 100-61-8
N-methylaniline

: 474352-69-7
N,3,5-trimethyl-N-phenylaniline

Conditions

Conditions	Yield
Stage #1: 1-chloro-3,5-dimethylbenzene; N-methylaniline With palladium diacetate; sodium sulfate; sodium t-butanolate; XPhos for 1h; Buchwald-Hartwig Coupling; Milling; Stage #2: In water; ethyl acetate for 0.0333333h; Buchwald-Hartwig Coupling; Milling;	90%

: 556-97-8
1-chloro-3,5-dimethylbenzene

: (Ra)-2,2'-bis(methoxy-methyloxy)-1,1'-binaphthalene

: (R)-3,3′-bis(3,5-dimethylphenyl)-2,2′-dihydroxy-1,1′-dinaphthyl

Conditions

Conditions	Yield
Stage #1: 1-chloro-3,5-dimethylbenzene; (Ra)-2,2'-bis(methoxy-methyloxy)-1,1'-binaphthalene With [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride; tert.-butyl lithium In n-heptane at 20℃; for 0.166667h; Schlenk technique; Stage #2: In n-heptane Schlenk technique; Acidic conditions;	88%

: 556-97-8
1-chloro-3,5-dimethylbenzene

: 73183-34-3
bis(pinacol)diborane

: 325142-93-6
2-(3,5-dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Conditions

Conditions	Yield
With p-phenylpyridine; sodium methylate In acetonitrile at 20℃; for 12h; Sealed tube; Inert atmosphere; Irradiation;	88%
With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; bis(dibenzylideneacetone)-palladium(0) In toluene at 105℃; for 18h; Sealed tube; Inert atmosphere;	80%
With [1,3-bis(cyclohexyl)imidazol-2-ylidene]copper(I) chloride; potassium tert-butylate In methyl cyclohexane at 90℃; for 42h; Inert atmosphere; Glovebox;	68%

: 556-97-8
1-chloro-3,5-dimethylbenzene

: 18412-55-0
triethoxy(o-tolyl)silane

: 76708-77-5
2,3′,5′-trimethyl-1,1′-biphenyl

Conditions

Conditions	Yield
With Pd((CH3)2C6H3NC(CH3)CHC(CH3)NC6H3(CH3)2)(CH3)(P(CH2CH3)3); tetrabutylammomium bromide; sodium hydroxide In water at 60℃; for 10h; Hiyama coupling; Inert atmosphere;	87%

: 556-97-8
1-chloro-3,5-dimethylbenzene

: 68971-87-9
(2-tolyl)tributyltin

: 76708-77-5
2,3′,5′-trimethyl-1,1′-biphenyl

Conditions

Conditions	Yield
With Pd((CH3)2C6H3NC(CH3)CHC(CH3)NC6H3(CH3)2)(CH3)(P(CH2CH3)3); cesium fluoride In tetrahydrofuran at 50℃; for 8h; Stille Cross Coupling;	87%

: 111-26-2
hexan-1-amine

: 556-97-8
1-chloro-3,5-dimethylbenzene

: N-n-hexyl-3,5-dimethylbenzenamine

Conditions

Conditions	Yield
With copper(l) iodide; C14H16N2O; caesium carbonate In N,N-dimethyl-formamide at 130℃; for 24h; Inert atmosphere; Sealed tube;	87%
With copper(l) iodide; C14H16N2O; caesium carbonate In N,N-dimethyl-formamide at 130℃; for 24h; Sealed tube; Inert atmosphere;	87%

: 637-89-8
4-sulfanylphenol

: 556-97-8
1-chloro-3,5-dimethylbenzene

: 4-(3,5-dimethylphenyl)sulfanylphenol

Conditions

Conditions	Yield
With C40H30Cl2N2NiO2S2; sodium hydroxide In N,N-dimethyl-formamide at 70℃; for 3h;	86%

: 124-38-9
carbon dioxide

: 556-97-8
1-chloro-3,5-dimethylbenzene

: 499-06-9
3,5-dimethylbenzoic acid

Conditions

Conditions	Yield
With manganese; 2,9-dibutyl-4,7-dimethyl-1,10-phenanthroline; tetraethylammonium iodide; lithium acetate; cobalt(II) bromide In N,N-dimethyl acetamide at 100℃; under 760.051 Torr; for 12h; Inert atmosphere; Schlenk technique;	84%

: 556-97-8
1-chloro-3,5-dimethylbenzene

: 66-25-1
hexanal

: 959706-71-9
(2Z)-2-butyl-4-(3,5-dimethylphenyl)-2-octenal

Conditions

Conditions	Yield
With caesium carbonate; palladium diacetate In N,N-dimethyl-formamide at 80℃; for 12h;	82%

: 556-97-8
1-chloro-3,5-dimethylbenzene

: 3419-91-8
N-(2-pyridyl)indole

: 2-(3,5-dimethylphenyl)-1-(pyridin-2-yl)-1H-indole

Conditions

Conditions	Yield
With 1,1'-bis-(diphenylphosphino)ferrocene; nickel diacetate; lithium hexamethyldisilazane In neat (no solvent) at 80℃; for 16h; Sealed tube; Glovebox; Inert atmosphere; regioselective reaction;	82%

: 556-97-8
1-chloro-3,5-dimethylbenzene

: 62358-81-0
1-(bromomethyl)-3-chloro-5-methylbenzene

Conditions

Conditions	Yield
With N-Bromosuccinimide; azobisisobutyronitrile In tetrachloromethane	80%
With N-Bromosuccinimide In tetrachloromethane for 3h; Heating / reflux; UV-irradiation;	68%
With N-Bromosuccinimide; dibenzoyl peroxide In tetrachloromethane for 0.333333h; Heating / reflux;	60%

: 58-08-2
3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione

: 556-97-8
1-chloro-3,5-dimethylbenzene

: 8-(3,5-dimethylphenyl)-1,3,7-trimethyl-1H-purine-3,7-dihydro-2,6-dione

Conditions

Conditions	Yield
With potassium phosphate; palladium diacetate In 1-methyl-pyrrolidin-2-one at 125℃; for 24h;	77%

: 556-97-8
1-chloro-3,5-dimethylbenzene

: 108-98-5
thiophenol

: 3,5-dimethylphenyl phenyl sulfide

Conditions

Conditions	Yield
With potassium hydroxide In water for 8h; Reflux;	77%
With C40H30Cl2N2NiO2S2; sodium hydroxide In N,N-dimethyl-formamide at 70℃; for 3h;	77%

: 556-97-8
1-chloro-3,5-dimethylbenzene

: N-(2-(methylthio)phenyl)ferrocene-1-carboxamide

: 2,5-bis(3,4-dimethylphenyl)-N-(quinolin-8-yl)ferrocenecarboxamide

Conditions

Conditions	Yield
With palladium diacetate; potassium carbonate; XPhos; Trimethylacetic acid In o-xylene at 190℃; for 21h; Schlenk technique; Inert atmosphere;	77%

: 556-97-8
1-chloro-3,5-dimethylbenzene

: 150-76-5
4-methoxy-phenol

: 120957-65-5
1-(4-methoxyphenoxy)-3,5-dimethylbenzene

Conditions

Conditions	Yield
With 2-acetonylpyridine; caesium carbonate; copper(I) bromide In dimethyl sulfoxide at 150℃; for 24h; Inert atmosphere; chemoselective reaction;	70%

: 556-97-8
1-chloro-3,5-dimethylbenzene

: 5123-13-7
5,5-dimethyl-2-phenyl-1,3,2-dioxaborinane

: 17057-88-4
3,5-dimethylbiphenyl

Conditions

Conditions	Yield
With potassium tert-butylate; cobalt(II) chloride; 1,3-bis[2,6-diisopropylphenyl]imidazolium chloride In tetrahydrofuran at 60℃; for 24h; Suzuki Coupling;	69%

: 556-97-8
1-chloro-3,5-dimethylbenzene

: 103-84-4
Acetanilid

: 51786-48-2
N-(3,5-dimethylphenyl)-N-phenylacetamide

Conditions

Conditions	Yield
With bis(η3-allyl-μ-chloropalladium(II)); bis(3,5-bis(trifluoromethyl)phenyl)(2’,4’,6’-triisopropyl-3,6-dimethoxy-[1,1’-biphenyl]-2-yl)phosphine; caesium carbonate In toluene at 130℃; for 17h; Inert atmosphere; Molecular sieve;	68%

: 556-97-8
1-chloro-3,5-dimethylbenzene

: 947-84-2
2-Biphenylcarboxylic acid

: 2-(3,5-dimethylphenyl)-6-phenylbenzoic acid

Conditions

Conditions	Yield
With 3 A molecular sieve; caesium carbonate; palladium diacetate In N,N-dimethyl-formamide at 20 - 145℃; for 26h;	67%

5-Chloro-1,3-xylene Chemical Properties

Chemical Name: 5-Chloro-1,3-xylene
IUPAC NAME: 1-Chloro-3,5-dimethylbenzene
CAS No.: 556-97-8
Molecular Formula: C₈H₉Cl
Molecular Weight: 140.61 g/mol
Density: 1.049 g/cm³
Flash Point: 63.1 °C
Boiling Point: 188.1 °C at 760 mmHg
Following is the structure of 1-Chloro-3,5-xylene (CAS No.556-97-8):

Product Categories about 1-Chloro-3,5-xylene (CAS No.556-97-8) are Halogen toluene ; Chlorine Compounds
The chemical synonymous of 1-Chloro-3,5-xylene (CAS No.556-97-8) are 5-Chloro-M-Xylene ; 1-Chloro-3,5-Dimethylbenzene ; 1-Chloro-3,5-Xylene ; 3,5-Dimethylchlorobenzene ; 3,5-Dimethylphenylchloride ; 5-Chloro-1,3-Xylene ; 5-Chloro-M-Xylen ; 1,3-Dimethyl-5-Chlorobenzene

5-Chloro-1,3-xylene Safety Profile

Experimental reproductive effects. When heated to decomposition it emits toxic fumes of Cl⁻.
Hazard Codes: Irritant Xi
Risk Statements about 1-Chloro-3,5-xylene (CAS No.556-97-8):
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements about 1-Chloro-3,5-xylene (CAS No.556-97-8):
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.

Product Name

5-Chloro-1,3-xylene

Synthetic route

5-Chloro-1,3-xylene Chemical Properties

5-Chloro-1,3-xylene Safety Profile

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