2,3-dimethyl-2,3-butane diol
bis(pinacol)diborane
Conditions | Yield |
---|---|
With tetrakis(dimethylamido)diborane In diethyl ether at 20℃; for 18h; Conversion of starting material; | 100% |
With tetrakis(dimethylamido)diborane at 50 - 100℃; for 0.616667h; Conversion of starting material; | 94.2% |
With tetrakis(dimethylamido)diborane In n-heptane at 40 - 98℃; for 0.6h; Conversion of starting material; | 90.5% |
tris(pentafluorophenyl)borate
4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane
B
2-phenyl-4,4,5,5-tetramethyl-1,3,2-dioxoborole
C
bis(pinacol)diborane
Conditions | Yield |
---|---|
at 20℃; for 12h; | A 73% B 80% C 41% |
2,3-dimethyl-2,3-butane diol
tetrakis(dimethylamido)diborane
bis(pinacol)diborane
Conditions | Yield |
---|---|
With hydrogenchloride In diethyl ether; toluene at 20℃; for 4h; Inert atmosphere; Cooling with ice; | 79% |
In diethyl ether N2-atmosphere; addn. of 2 equiv. diol to B-compd., stirring for at room temp. for 5 h; cooling to -78°C, addn. of excess 1 M HCl in Et2O, slow warming to room temp., solvent removal (vac.), extn. into hexane, filtration (Celite), solvent removal (vac.); elem. anal.; | 76% |
In benzene dropwise addn. of pinakol in benzene to a soln. of B2(NMe2)4 in benzeneunder N2 (stirring), addn. of a 2.7 M HCl soln. in ether, stirring (4 h); fritting from insolubles, evapn. of solvent (vac.), recrystn. (pentane); elem. anal.; | 71% |
With potassium acetate In toluene at 80℃; for 2h; |
A
(C5H3N(C(CH3)3))2Ir(C8H12)(1+)*CF3SO3(1-)=[(C5H3N(C(CH3)3))2Ir(C8H12)][CF3SO3]
B
bis(pinacol)diborane
Conditions | Yield |
---|---|
In benzene-d6 at 80°C; | A n/a B 75% |
tris(pentafluorophenyl)borate
B
2-phenyl-4,4,5,5-tetramethyl-1,3,2-dioxoborole
C
bis(pinacol)diborane
Conditions | Yield |
---|---|
With hydrogen at 20℃; under 3000.3 Torr; for 12h; | A 71% B 73% C 52% |
2,3-dimethyl-2,3-butane diol
tetrakis(tetrahydropyrrole)boron
bis(pinacol)diborane
Conditions | Yield |
---|---|
In toluene at 90 - 100℃; Inert atmosphere; Autoclave; Large scale; | 69% |
ethene
tris(pentafluorophenyl)borate
B
2-phenyl-4,4,5,5-tetramethyl-1,3,2-dioxoborole
C
bis(pinacol)diborane
Conditions | Yield |
---|---|
at 20℃; under 45004.5 Torr; for 12h; | A 64% B n/a C n/a |
4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane
bis(pinacol)diborane
Conditions | Yield |
---|---|
With C25H36FeN2Si for 10h; Inert atmosphere; Reflux; | 62% |
With C3H10B(1-)*K(1+) In neat (no solvent) at 25℃; for 16h; Inert atmosphere; Schlenk technique; | 44% |
With platinum on aluminium oxide for 48h; Heating; | |
With catalyst: Rh or Pd or Pt on alumina In not given Soxlet reactor, HBPin distilled in presence of catalyst: Rh/alumina for 20 h or Pd/alumina for 40 h or Pt/alumina for 20 h; | |
With carbonylhydrido[6-(di-tert-butylphosphinomethylene)-2-(N,N-diethylaminomethyl)-1,6-dihydropyridine]ruthenium(II) In tetrahydrofuran; 1,4-dioxane for 18h; Reflux; | 10 %Chromat. |
2,3-dimethyl-2,3-butane diol
2,2'-bis(1,3,2-benzodioxaborole)
tert-butyl 4-(((methylthio)carbonothioyl)oxy)piperidine-1-carboxylate
A
4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)piperidine-1-carboxylic acid tert-butyl ester
B
bis(pinacol)diborane
Conditions | Yield |
---|---|
Stage #1: 2,2'-bis(1,3,2-benzodioxaborole); tert-butyl 4-(((methylthio)carbonothioyl)oxy)piperidine-1-carboxylate With 2,2'-azobis(isobutyronitrile); tris-(trimethylsilyl)silane In N,N-dimethyl acetamide for 24h; Inert atmosphere; Schlenk technique; Irradiation; Stage #2: 2,3-dimethyl-2,3-butane diol With triethylamine In N,N-dimethyl acetamide for 2h; Inert atmosphere; Schlenk technique; Irradiation; | A 58% B 17% |
2-phenyl-4,4,5,5-tetramethyl-1,3,2-dioxoborole
para-chlorobenzoic acid
A
biphenyl
B
pinacolboronic acid
C
bis(pinacol)diborane
D
biphenyl-4-carboxylic acid
Conditions | Yield |
---|---|
With water In water-d2 at 27℃; for 24h; Inert atmosphere; | A 49% B n/a C n/a D 50% |
2,3-dimethyl-2,3-butane diol
4-tert-Butylcatechol
boron trichloride
bis(pinacol)diborane
Conditions | Yield |
---|---|
With sodium amalgam; lithium dimethylamide In n-heptane; pentane under inert atm. to soln. BCl3 in heptane at 0°C soln. catechol in pentane was added, stirred 0.5 h at 0°C and 1 h at room temp., solvent was evapd, residue was dissolved in toluene, Na/Hg amalgam was adde and heated at 90°C for 6 h; soln. was filtered, pinacol was added, soln. was stirred at room temp. for 1 h, solvent was evapd., Et2O was added, LiNMe2 in Et2O was added slowly, solvent was evapd., chromy. on alumina; | 46% |
With sodium amalgam; lithium dimethylamide In n-heptane; pentane under inert atm. to soln. BCl3 in heptane at 0°C soln. catechol in pentane was added, stirred 0.5 h at 0°C and 1 h at room temp., solvent was evapd, residue was dissolved in toluene, Na/Hg amalgam was adde and heated at 90°C for 6 h; soln. was filtered, pinacol was added, soln. was stirred at room temp. for 1 h, solvent was evapd., Et2O was added, LiNMe2 in Et2O was added slowly, solvent was evapd., residue was extd. with pentane, concd., and crystd. at -35°C; | 32% |
4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane
C
bis(pinacol)diborane
Conditions | Yield |
---|---|
In toluene at -78 - 20℃; Inert atmosphere; Schlenk technique; | A 5% B 27% C 18 mg |
2,3-dimethyl-2,3-butane diol
3,5-Di-tert-butylcatechol
boron trichloride
bis(pinacol)diborane
Conditions | Yield |
---|---|
With sodium amalgam In n-heptane; pentane under inert atm. to soln. BCl3 in heptane at 0°C soln. catechol in pentane was added, stirred 0.5 h at 0°C and 1 h at room temp., solvent was evapd, residue was dissolved in toluene, Na/Hg amalgam was adde and heated at 90°C for 6 h; soln. was filtered, pinacol was added, soln. was stirred at room temp. for 1 h, soln. was concd., layered with pentane and cooled to -35°C; | 23% |
4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane
benzene
A
2-phenyl-4,4,5,5-tetramethyl-1,3,2-dioxoborole
B
bis(pinacol)diborane
Conditions | Yield |
---|---|
trans-chloro(dinitrogen)bis(tri-isopropylphosphine)rhodium(I) In benzene 1 M or 1/3 M soln. heated at 140°C for 58 h; various condns. various yield; | A 20% B 7% |
B
bis(pinacol)diborane
Conditions | Yield |
---|---|
In Cyclohexane-d12 at 25℃; Kinetics; Further Variations:; Temperatures; |
1,2-B2(NMe2)2(catecholate)
2,3-dimethyl-2,3-butane diol
B
2,2'-bis(1,3,2-benzodioxaborole)
C
bis(pinacol)diborane
Conditions | Yield |
---|---|
In tetrahydrofuran at -78℃; | |
With HCl In tetrahydrofuran; diethyl ether pinacol and slight excess of HCl in diethylether added to (C6H4O2)B2(N(CH3)2)2 (generated in situ in THF) at -78°C; filtered, volatiles removed from filtrate, extraction with hexane, subsequent extraction with benzene yields B2(catecholate)2; |
2,3-dimethyl-2,3-butane diol
cis-[Pt(difluoroboryl)2(PPh3)2]
A
tris(triphenylphosphine)platinum(0)
B
(triphenylphosphine)2PtHCl
C
bis(pinacol)diborane
Conditions | Yield |
---|---|
With 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane under inert atmosphere, standard Schlenk and vac. line techniques; react. between Pt complex and pinacol in the presence of DBU in CH2Cl2; monitored by NMR spectroscopy; |
dichlorobis(dimethylamino)diborane(4)
A
tetrakis(dimethylamido)diborane
C
bis(pinacol)diborane
Conditions | Yield |
---|---|
In not given tetrachlorocatechol added to (C6H4O2)B2(N(CH3)2)2 generated in toluene, volatiles removed, residue dissolved in (C2H5)2O, HCl added; |
2-{bis(dimethylamino)boryl}-1,3,2-benzodithiaborole
2,2'-bis(1,3,2-benzodioxaborole)
B
bis(pinacol)diborane
C
2,2'bi-1,3,2-benzodithiaborole
Conditions | Yield |
---|---|
With HCl In tetrahydrofuran |
2-{bis(dimethylamino)boryl}-1,3,2-benzodithiaborole
2,3-dimethyl-2,3-butane diol
B
bis(pinacol)diborane
C
2,2'bi-1,3,2-benzodithiaborole
Conditions | Yield |
---|---|
With HCl In tetrahydrofuran |
B
bis(pinacol)diborane
Conditions | Yield |
---|---|
In Cyclohexane-d12 Kinetics; (Schlenk; N2 atm.) complex was added to a soln. of boryl-compound in cyclohexane-d12 at -30°C (NMR tube), heated to 0°C, heated to40°C; not sepd., detected by NMR spectra; |
Conditions | Yield |
---|---|
With potassium acetate at 80℃; |
bis(pinacol)diborane
Conditions | Yield |
---|---|
With Pt/Al2O3; triethylamine In 1,3,5-trimethyl-benzene at 120℃; Reagent/catalyst; | 1.36 g |
4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane
B
C55H47P3PdSi
C
bis(pinacol)diborane
Conditions | Yield |
---|---|
In benzene-d6 at 29.84℃; for 1h; Inert atmosphere; | A n/a B n/a C 65 %Chromat. |
4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane
B
C55H47P3PdSi
C
bis(pinacol)diborane
Conditions | Yield |
---|---|
In benzene-d6 at 29.84℃; for 1h; Inert atmosphere; | A n/a B n/a C 17 %Chromat. |
4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane
A
C55H47P3PdSi
B
bis(pinacol)diborane
Conditions | Yield |
---|---|
In benzene-d6 at 24.84℃; for 48h; Equilibrium constant; Inert atmosphere; | A 30 %Spectr. B n/a |
4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane
A
C40H41P3PdSi
B
bis(pinacol)diborane
Conditions | Yield |
---|---|
In benzene-d6 at 24.84℃; for 24h; Equilibrium constant; Inert atmosphere; | A 17 %Spectr. B n/a |
dimethylphenyl(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)silane
A
dimethyl(phenyl)((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)oxy)silane
B
dimethylphenylsilanol
C
1,1,3,3-tetramethyl-1,3-diphenyldisiloxane
D
bis(pinacol)diborane
Conditions | Yield |
---|---|
With Au-TiO2 In dichloromethane at 25℃; for 2h; |
2,3-dimethyl-2,3-butane diol
tetrakis(dimethylamido)diborane
N,N'-dimethyl-1,2-phenylenediamine
A
1,1-B2(1,2-(NMe)2C6H4)2
B
pinB-Bdmab
C
bis(pinacol)diborane
Conditions | Yield |
---|---|
With hydrogenchloride In diethyl ether; dichloromethane at -5 - 20℃; for 72h; Inert atmosphere; Schlenk technique; |
2,3-dimethyl-2,3-butane diol
2-[(1E)-but-1-en-1-yl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
B
bis(pinacol)diborane
Conditions | Yield |
---|---|
Stage #1: 2-[(1E)-but-1-en-1-yl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; B2(cat)2 With [Pt(1,5-diphenylpenta-1,4-dien-3-one)3]; (3aR,8aR)-4,4,8,8-tetrakis(3,5-diisopropylphenyl)-2,2-dimethyl-6-phenyltetrahydro-[1,3]dioxolo[4,5-e][1,3,2]dioxaphosphepine In tetrahydrofuran at 70℃; for 24h; Inert atmosphere; Sealed tube; Stage #2: 2,3-dimethyl-2,3-butane diol In tetrahydrofuran at 20℃; for 14h; Inert atmosphere; Sealed tube; Overall yield = 77 %; Overall yield = 1.46 g; | A 24.3 mg B n/a |
1,3-dibromo-5-t-butylbenzene
bis(pinacol)diborane
Conditions | Yield |
---|---|
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate In N,N-dimethyl-formamide at 100℃; for 4h; Inert atmosphere; | 100% |
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate In 1,4-dioxane at 100℃; for 12h; Inert atmosphere; | 63% |
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate In 1,4-dioxane at 100℃; for 12h; Inert atmosphere; | 63% |
With potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride In N,N-dimethyl-formamide at 80℃; for 11h; Substitution; | 55% |
4-Trifluoromethanesulfonyloxy-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester
bis(pinacol)diborane
tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate
Conditions | Yield |
---|---|
With 1,1'-bis(diphenylphosphino)ferrocene; potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride at 80℃; | 100% |
With 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate In 1,4-dioxane at 80℃; | 100% |
With 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate In 1,4-dioxane at 80℃; Inert atmosphere; | 100% |
norborn-2-ene
bis(pinacol)diborane
Conditions | Yield |
---|---|
With tris(bicyclo[2.2.1]heptene)palladium; triphenylphosphine at 20℃; for 2h; | 100% |
4-Octyne
bis(pinacol)diborane
Conditions | Yield |
---|---|
With tris(bicyclo[2.2.1]heptene)palladium; triphenylphosphine at 20℃; for 9h; | 100% |
With tetrakis(triphenylphosphine)platinum In N,N-dimethyl-formamide at 80℃; for 12h; Inert atmosphere; | 98% |
tetrakis(triphenylphosphine)platinum In N,N-dimethyl-formamide for 12h; Heating; | 95% |
1-Heptyne
bis(pinacol)diborane
Conditions | Yield |
---|---|
With tris(bicyclo[2.2.1]heptene)palladium; triphenylphosphine at 20℃; for 12h; | 100% |
With gold nanoparticles supported on titanium dioxide at 65℃; for 2h; chemoselective reaction; | 91% |
With methanol; potassium carbonate In diethyl ether at 40℃; for 12h; Inert atmosphere; chemoselective reaction; | 72% |
1,2-bis(4-methylphenyl)acetylene
bis(pinacol)diborane
Conditions | Yield |
---|---|
With tris(bicyclo[2.2.1]heptene)palladium; triphenylphosphine at 20℃; for 5h; | 100% |
ethylenebis(triphenylphosphine)platinum(0) In toluene N2-atmosphere; 80°C (3 h); evapn. (vac.); detd. by GC / MS and NMR spectroscopy; | |
cis-[(PPh3)2Pt(B(1,2-O2-4-tBuC6H3))2] In toluene N2-atmosphere; 80°C (3 h); evapn. (vac.); detd. by GC / MS and NMR spectroscopy; | |
With tetrakis(triphenylphosphine)platinum In N,N-dimethyl-formamide at 80℃; |
4,4'-dimethoxydiphenylacetylene
bis(pinacol)diborane
(Z)-1,2-bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2-bis(4-methoxyphenyl)ethene
Conditions | Yield |
---|---|
With tris(bicyclo[2.2.1]heptene)palladium; triphenylphosphine at 20℃; for 5.5h; | 100% |
With copper diacetate; tricyclohexylphosphine In toluene at 80℃; for 16h; Inert atmosphere; | 76% |
With tetrakis(triphenylphosphine)platinum In toluene at 110℃; for 24h; Inert atmosphere; | 50% |
4-methoxyphenylacetylen
bis(pinacol)diborane
Conditions | Yield |
---|---|
With tris(bicyclo[2.2.1]heptene)palladium; triphenylphosphine at 20℃; for 1.3h; | 100% |
With atomically dispersed Pt on beta-cyclodextrin-containing polymer In toluene at 100℃; for 2h; | 90% |
With Pd(1,3,4,5-tetramethylimidazol-2-ylidene)2(diphenylacetylene) In benzene at 20℃; for 4h; stereoselective reaction; | 88% |
bis(pinacol)diborane
1,2-bis(4-(trifluoromethyl)phenyl)ethyne
CF3C6H4C(BO2C2(CH3)4)C(BO2C2(CH3)4)C6H4CF3
Conditions | Yield |
---|---|
With tris(norbornene)platinum(0); Diphenyl-o-tolylphosphin In toluene at 20℃; for 4.3h; Product distribution; Kinetics; Further Variations:; Reagents; Solvents; | 100% |
With platinum-based catalyst Inert atmosphere; |
1,2-dichloro-benzene
bis(pinacol)diborane
2-(3,4-dichlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
Conditions | Yield |
---|---|
With [Ir(COD)(OMe)]2-Covalent organic framework (4-iPr) In n-heptane at 100℃; for 24h; Inert atmosphere; | 100% |
Stage #1: bis(pinacol)diborane With C24H28ClIrN2O In n-heptane; isopropyl alcohol at 75℃; for 1h; Sealed tube; Cooling with liquid nitrogen; Inert atmosphere; Stage #2: 1,2-dichloro-benzene In n-heptane; isopropyl alcohol at 75℃; for 18h; Catalytic behavior; Sealed tube; Inert atmosphere; | 97% |
With [Ir(OMe)(1,5-cyclooctadiene)]2; C88H164N2 In n-heptane at 25℃; for 18h; Reagent/catalyst; Inert atmosphere; | 95% |
bis(pinacol)diborane
benzene
2-phenyl-4,4,5,5-tetramethyl-1,3,2-dioxoborole
Conditions | Yield |
---|---|
With [Ir(COD)(OMe)]2-Covalent organic framework (4-iPr) at 100℃; for 24h; Reagent/catalyst; Inert atmosphere; | 100% |
With iridium-1,5-cyclooctadiene complex immobilized 2,2'-bipyridine-functionalized organosilica nanotubes at 80℃; for 12h; Catalytic behavior; Kinetics; Reagent/catalyst; Inert atmosphere; | 97% |
With [Ir(OMe)(1,5-cyclooctadiene)]2 In benzene at 80℃; for 12h; Kinetics; Reagent/catalyst; Schlenk technique; Inert atmosphere; | 94% |
4-bromo-2-methoxypyridine
bis(pinacol)diborane
2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
Conditions | Yield |
---|---|
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate In N,N-dimethyl-formamide at 80℃; | 100% |
With C37H51ClFeNPPd; potassium acetate In 1,4-dioxane at 80℃; for 3h; Suzuki-Miyaura coupling; Inert atmosphere; | 91% |
With potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride In N,N-dimethyl-formamide at 80℃; | 74% |
1,1-Diphenylethylene
bis(pinacol)diborane
2-(2,2-diphenylvinyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
Conditions | Yield |
---|---|
With (CH3Si(C6H4P(C6H3(CF3)2)2)2)Pd(SO3CF3); triethylaluminum In toluene at 20℃; for 24h; Inert atmosphere; | 100% |
With 2-Adamantanone In para-xylene at 130℃; under 760.051 Torr; for 20h; Inert atmosphere; regioselective reaction; | 82% |
trans-carbonyl(chloro)bis(triphenylphosphine)rhodium(I) In toluene; acetonitrile at 80℃; for 72h; |
3-(trifluoromethyl)anisole
bis(pinacol)diborane
2-(3-methoxy-5-(trifluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
Conditions | Yield |
---|---|
With [Ir(COD)(OMe)]2-Covalent organic framework (4-iPr) In n-heptane at 100℃; for 24h; Reagent/catalyst; Inert atmosphere; | 100% |
With pinacol borane; 4,4'-di-tert-butylbipyridine In cyclohexane at 80℃; | 77% |
With bis(1,5-cyclooctadiene)diiridium(I) dichloride; sodium methylate; 4,4'-di-tert-butyl-2,2'-bipyridine at 90℃; for 96h; Schlenk technique; Sealed tube; Inert atmosphere; | 60% |
4-bromo-1H-indole
bis(pinacol)diborane
indole-4-boronic acid pinacol ester
Conditions | Yield |
---|---|
With potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 In dimethyl sulfoxide at 90℃; for 4h; | 100% |
With potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 In dimethyl sulfoxide at 90℃; for 4h; | 100% |
With tris-(dibenzylideneacetone)dipalladium(0); potassium acetate; XPhos In 1,4-dioxane at 110℃; for 20h; Miyaura borylation; Inert atmosphere; | 93% |
thiophene
bis(pinacol)diborane
2-thiopheneboronic acid pinacol ester
Conditions | Yield |
---|---|
With [Ir(COD)(OMe)]2-Covalent organic framework (4-iPr) at 100℃; for 24h; Inert atmosphere; | 100% |
In octane at 25℃; for 4h; Conversion of starting material; | 88% |
In octane at 25℃; for 4h; Conversion of starting material; | 86% |
5'-bromo-2'-fluorobiphenyl-2-carbonitrile
bis(pinacol)diborane
2'-fluoro-5'-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)biphenyl-2-carbonitrile
Conditions | Yield |
---|---|
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate; dimethyl sulfoxide In 1,4-dioxane at 90℃; for 16h; Miyaura reaction; | 100% |
With potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride In 1,4-dioxane; dimethyl sulfoxide at 90℃; for 16h; | 100% |
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate In 1,4-dioxane at 90℃; Miyaura reaction; | 95% |
bis(pinacol)diborane
1-bromo-2-[2-[tris(1-methylethyl)silyl]ethynyl]benzene
tris(1-methylethyl){[2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]ethynyl}silane
Conditions | Yield |
---|---|
With potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride In dimethyl sulfoxide at 90℃; for 18h; | 100% |
With potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride In dimethyl sulfoxide (N2); for 18 h at 90°C; cooled to 20°C, Et2O added, washed with satd. aq. NaH2PO4 and satd. aq. NaCl, filtered (SiO2, hexane/EtOAc), evapd. (vac.), obtained as an oil; | 99% |
trifluoromethanesulfonic acid 2'-cyanobiphenyl-3-yl ester
bis(pinacol)diborane
3'-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-biphenyl-2-carbonitrile
Conditions | Yield |
---|---|
With 1,1'-bis-(diphenylphosphino)ferrocene; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate In 1,4-dioxane at 85℃; for 18h; | 100% |
With potassium acetate; 1,1'-bis-(diphenylphosphino)ferrocene; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 In 1,4-dioxane at 85℃; for 18h; | 100% |
(4-bromo-phenyl)-acetic acid methyl ester
bis(pinacol)diborane
methyl [4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetate
Conditions | Yield |
---|---|
With potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride In 1,4-dioxane; dichloromethane at 90℃; for 4h; | 100% |
With potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride In 1,4-dioxane; dichloromethane at 90℃; for 4h; | 100% |
With dichloro bis(acetonitrile) palladium(II); 1-(diphenylphosphino)ferrocene-1-(di-tert-butylphosphino)ferrocene; potassium acetate In 1,4-dioxane at 90℃; for 20h; Inert atmosphere; | 83% |
t-butyl 2-(4-bromophenyl)ethylcarbamate
bis(pinacol)diborane
tert-butyl N-[2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]ethyl]carbamate
Conditions | Yield |
---|---|
With 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate In 1,4-dioxane at 80℃; for 18h; | 100% |
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate In 1,4-dioxane at 120℃; for 12h; Inert atmosphere; | 85% |
With potassium acetate In 1,4-dioxane at 80℃; Inert atmosphere; | 80% |
1,3-dibromobenzene
bis(pinacol)diborane
4,4,5,5-tetramethyl-2-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1,3,2-dioxaborolane
Conditions | Yield |
---|---|
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate In N,N-dimethyl-formamide at 90℃; for 48h; Inert atmosphere; Schlenk technique; | 100% |
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate In N,N-dimethyl-formamide at 80℃; for 16h; Inert atmosphere; Schlenk technique; | 96% |
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate In N,N-dimethyl-formamide at 80℃; for 24h; Suzuki-Miyaura Coupling; | 93% |
methyl 2-(3-bromophenyl)acetatee
bis(pinacol)diborane
methyl 2-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetate
Conditions | Yield |
---|---|
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate In 1,4-dioxane at 85℃; for 4h; Inert atmosphere; | 100% |
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate In 1,4-dioxane at 85℃; for 4h; Inert atmosphere; | 100% |
With potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 In dimethyl sulfoxide at 80℃; for 3h; Suzuki reaction; | 99% |
Conditions | Yield |
---|---|
With potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 In dimethyl sulfoxide at 110 - 130℃; | 100% |
Conditions | Yield |
---|---|
With potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 In dimethyl sulfoxide at 120℃; for 16h; | 100% |
4-(4-bromophenoxy)-2-methylpyridine
bis(pinacol)diborane
4-[4-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)phenoxy]-2-methylpyridine
Conditions | Yield |
---|---|
With potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 In 1,4-dioxane; N,N-dimethyl-formamide at 150℃; for 0.166667h; Microwave irradiation; | 100% |
With potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 In dimethyl sulfoxide at 110℃; for 16h; | 100% |
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate | 89% |
bis(pinacol)diborane
2-chloro-6-methoxypyrazine
2-methoxy-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazine
Conditions | Yield |
---|---|
With water; potassium acetate; tris-(dibenzylideneacetone)dipalladium(0); tricyclohexylphosphine In 1,2-dimethoxyethane at 150℃; for 3h; | 100% |
With potassium acetate; tris-(dibenzylideneacetone)dipalladium(0); tricyclohexylphosphine In 1,2-dimethoxyethane at 150℃; for 3h; Microwave irradiation; | 100% |
With tris-(dibenzylideneacetone)dipalladium(0); potassium acetate; tricyclohexylphosphine In 1,2-dimethoxyethane at 150℃; for 3h; Inert atmosphere; Microwave irradiation; | 600 mg |
4-bromo-2,6-difluorobenzonitrile
bis(pinacol)diborane
2,6-difluoro-4-(4,4,5,5- tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile
Conditions | Yield |
---|---|
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate In 1,4-dioxane at 110℃; for 2h; Inert atmosphere; | 100% |
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate In 1,4-dioxane at 100℃; for 6h; Inert atmosphere; | 55% |
With tris-(dibenzylideneacetone)dipalladium(0); potassium acetate; XPhos In toluene at 110℃; for 16h; Inert atmosphere; | 35% |
5-heptyl-5'-[4-(trifluoromethylsulfonyl)phenyl]-2,2'-bipyridine
bis(pinacol)diborane
Conditions | Yield |
---|---|
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate In 1,4-dioxane at 120℃; | 100% |
With 1,1'-bis-(diphenylphosphino)ferrocene; potassium acetate; PdCl2(1,1'-bis(diphenylphopsphino)ferrocene) In 1,4-dioxane at 120℃; for 18h; | 90% |
1. Introduction of Bis(pinacolato)diboron
Bis(pinacolato)diboron, its Synonyms are 2,2'-bi-1,3,2-dioxaborolane, 4,4,4',4',5,5,5',5'-octamethyl-; 4,4,4',4',5,5,5',5'-Octamethyl-2,2'-bi-1,3,2-dioxaborolane; 4,4,4',4',5,5,5',5'-Octamethyl-2,2'-bi(1,3,2-dioxaborolane); Diboron pinacol ester. It is white crystal powder. The IUPAC Name of Bis(pinacolato)diboron is 4,4,5,5-Tetramethyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3,2-dioxaborolane.
2. Properties of Bis(pinacolato)diboron
Melting Point: 137-140 °C(lit.)
storage temperature: 0-6 °C
Index of Refraction: 1.432
Molar Refractivity: 67.45 cm3
Molar Volume: 259.8 cm3
Surface Tension: 25.9 dyne/cm
Density: 0.97 g/cm3
Flash Point: 88.4 °C
Enthalpy of Vaporization: 44.04 kJ/mol
Boiling Point: 222.6 °C at 760 mmHg
Vapour Pressure of Bis(pinacolato)diboron (CAS NO.73183-34-3): 0.15 mmHg at 25 °C
3. Structure Descriptors of Bis(pinacolato)diboron
SMILES: O1B(OC(C)(C)C1(C)C)B2OC(C)(C)C(O2)(C)C Copy
InChI: InChI=1/C12H24B2O4/c1-9(2)10(3,4)16-13(15-9)14-17-11(5,6)12(7,8)18-14/h1-8H3
Product Categories: Pharmaceutical Intermediates; Boron Compounds; blocks; BoronicAcids; Miscellaneous; Small molecule; Aliphatics; Boronic Acids & Esters; DIBORON SERIES; Reagent; Organoborons; Diboron Esters; B (Classes of Boron Compounds); CHIRAL CHEMICALS; Boronic Acids & Esters
4. Safety Information of Bis(pinacolato)diboron
Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-20/21/22
R36/37/38:Irritating to eyes, respiratory system and skin.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 26-37/39-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S37/39:Wear suitable gloves and eye/face protection.
S36:Wear suitable protective clothing.
WGK Germany: 3
Hazard Note: Irritant
HazardClass of Bis(pinacolato)diboron: IRRITANT, IRRITANT-HARMFUL, KEEP COLD
5. Use of Bis(pinacolato)diboron
Bis(pinacolato)diboron is mainly used as organic reagents, pharmaceutical intermediates, pharmaceutical intermediates.
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