Product Name

  • Name

    Trichloroacetaldehyde

  • EINECS 200-911-5
  • CAS No. 75-87-6
  • Article Data138
  • CAS DataBase
  • Density 1.5121 g/cm3
  • Solubility forms soluble hydrate in water; miscible with ethanol, diethyl ether and chloroform
  • Melting Point -57.5°C
  • Formula C2HCl3O
  • Boiling Point 97.8 °C at 760 mmHg
  • Molecular Weight 147.388
  • Flash Point 14.9 °C
  • Transport Information UN 2075
  • Appearance colourless oily liquid with a pungent odour
  • Safety 26-36/37-45-7/9
  • Risk Codes 23-36/37/38
  • Molecular Structure Molecular Structure of 75-87-6 (Trichloroacetaldehyde)
  • Hazard Symbols ToxicT
  • Synonyms Acetaldehyde,trichloro- (9CI);Chloral (8CI);2,2,2-Trichloroacetaldehyde;2,2,2-Trichloroethanal;Anhydrous chloral;Grasex;Sporotal 100;Trichloroacetaldehyde;Trichloroethanal;
  • PSA 17.07000
  • LogP 1.55550

Synthetic route

trichloroethylene epoxide
16967-79-6

trichloroethylene epoxide

chloral
75-87-6

chloral

Conditions
ConditionsYield
With sulfuric acid at 100℃; for 2h;100%
iron(III) chloride at 60℃; for 1h; sealed tube; Yield given;
chloral hydrate
302-17-0

chloral hydrate

chloral
75-87-6

chloral

Conditions
ConditionsYield
With phosphorus pentoxide; sulfuric acid99%
With diethyl ether; water; chlorine at 80℃;
With sulfuric acid
Trichloroacetyl chloride
76-02-8

Trichloroacetyl chloride

chloral
75-87-6

chloral

Conditions
ConditionsYield
With sodium tris(tert-butoxo)aluminium hydride In tetrahydrofuran; diethylene glycol dimethyl ether at -78℃; for 1h;91%
With ammonium hydroxide; formic acid In diethyl ether; chloroform for 0.75h; Ambient temperature;76%
Stage #1: trifluoroacetyl chloride With aluminium hydride In tetrahydrofuran at 20℃; for 1h; Metallation;
Stage #2: With pyridinium chlorochromate In tetrahydrofuran; dichloromethane at 20℃; for 6h; Oxidation;
95 % Chromat.
1,2,2,2-Tetrachloroethyl tert-Butyl Carbonate
98015-52-2

1,2,2,2-Tetrachloroethyl tert-Butyl Carbonate

L-proline
147-85-3

L-proline

A

1-(tert-butoxycarbonyl)-L-proline
15761-39-4

1-(tert-butoxycarbonyl)-L-proline

B

chloral
75-87-6

chloral

Conditions
ConditionsYield
With triethylamine In 1,4-dioxane; water at 20℃; for 5h; Product distribution; var. amines, other 1-chloroalkyl carbonate, other basic reagent and time;A 91%
B n/a
paracetaldehyde
123-63-7

paracetaldehyde

A

2-chloroethanal
107-20-0

2-chloroethanal

B

2,2-dichloroacetaldehyde
79-02-7

2,2-dichloroacetaldehyde

C

chloral
75-87-6

chloral

Conditions
ConditionsYield
With antimony(III) chloride; chlorine at 10 - 80℃; for 18h; Product distribution; var. catalysts, var. time;A 0.7%
B 71.3%
C 2.6%
5-(p-methoxyphenyl)-2-trichloromethyl-1,3,4-oxathiazole
73501-02-7

5-(p-methoxyphenyl)-2-trichloromethyl-1,3,4-oxathiazole

propynoic acid ethyl ester
623-47-2

propynoic acid ethyl ester

A

ethyl 3-(p-methoxyphenyl)isothiazole-4-carboxylate
76162-57-7

ethyl 3-(p-methoxyphenyl)isothiazole-4-carboxylate

B

ethyl 3-(p-methoxyphenyl)isothiazole-5-carboxylate
76162-58-8

ethyl 3-(p-methoxyphenyl)isothiazole-5-carboxylate

C

chloral
75-87-6

chloral

D

4-methoxybenzonitrile
874-90-8

4-methoxybenzonitrile

E

S

S

Conditions
ConditionsYield
In 1,3,5-trimethyl-benzene at 161℃; for 19h;A 17%
B 13%
C n/a
D 68%
E n/a
Trichloroethylene
79-01-6

Trichloroethylene

chloral
75-87-6

chloral

Conditions
ConditionsYield
With tetrachloromethane; chlorine monoxide at -20℃;
With hypochloric acid
Trichloroethylene
79-01-6

Trichloroethylene

A

dichloroacethyl chloride
79-36-7

dichloroacethyl chloride

B

chloral
75-87-6

chloral

Conditions
ConditionsYield
With oxygen Umsetzung der bis 107grad siedenden Anteile des Reaktionsprodukts mit Metallchloriden wie SbCl5,FeCl3 oder AlCl3;
1,1,1-trichloro-2,2-diethoxy-ethane
599-97-3

1,1,1-trichloro-2,2-diethoxy-ethane

chloral
75-87-6

chloral

Conditions
ConditionsYield
With sulfuric acid at 150℃;
at 200℃;
(2,2,2-trichloro-1-hydroxyethyl)urea
2000-40-0

(2,2,2-trichloro-1-hydroxyethyl)urea

A

chloral
75-87-6

chloral

B

isocyanuric acid
108-80-5

isocyanuric acid

Conditions
ConditionsYield
at 150℃;
2,2-diacetoxy-1,1,1-trichloro-ethane
24298-56-4

2,2-diacetoxy-1,1,1-trichloro-ethane

A

acetic anhydride
108-24-7

acetic anhydride

B

chloral
75-87-6

chloral

Conditions
ConditionsYield
at 210 - 290℃; Kinetics;
2-(2,2,2-trichloro-1-hydroxy-ethyl)-acetoacetic acid ethyl ester
75456-97-2

2-(2,2,2-trichloro-1-hydroxy-ethyl)-acetoacetic acid ethyl ester

A

ethyl acetoacetate
141-97-9

ethyl acetoacetate

B

chloral
75-87-6

chloral

Conditions
ConditionsYield
Erhitzen;
N,N'-bis-(2,2,2-trichloro-1-hydroxy-ethyl)-oxalamide
75457-07-7

N,N'-bis-(2,2,2-trichloro-1-hydroxy-ethyl)-oxalamide

A

Oxalamide
471-46-5

Oxalamide

B

chloral
75-87-6

chloral

N,N'-(1,3-bis-trichloromethyl-2-oxa-propanediyl)-bis-carbamic acid dimethyl ester
198283-38-4

N,N'-(1,3-bis-trichloromethyl-2-oxa-propanediyl)-bis-carbamic acid dimethyl ester

chloral
75-87-6

chloral

Conditions
ConditionsYield
at 200℃;
benzyl 2,2,2-trichloroacetate
26827-38-3

benzyl 2,2,2-trichloroacetate

A

benzaldehyde
100-52-7

benzaldehyde

B

chloral
75-87-6

chloral

Conditions
ConditionsYield
at 220℃;
3-acridin-9-yl-1,1,1-trichloro-propan-2-ol
91025-27-3

3-acridin-9-yl-1,1,1-trichloro-propan-2-ol

A

9-methyl-acridine
611-64-3

9-methyl-acridine

B

chloral
75-87-6

chloral

Conditions
ConditionsYield
beim Erhitzen;
trichloro-acetic acid phenethyl ester
71965-07-6

trichloro-acetic acid phenethyl ester

A

phenylacetaldehyde
122-78-1

phenylacetaldehyde

B

chloral
75-87-6

chloral

Conditions
ConditionsYield
at 240℃;
N-phenyl-N'-(2,2,2-trichloro-1-hydroxy-ethyl)-oxalamide
859068-72-7

N-phenyl-N'-(2,2,2-trichloro-1-hydroxy-ethyl)-oxalamide

A

oxanilic acid
500-72-1

oxanilic acid

B

chloral
75-87-6

chloral

chloral allyl hemiacetal
1873-15-0

chloral allyl hemiacetal

benzyl chloride
100-44-7

benzyl chloride

A

vinyl benzoate
583-04-0

vinyl benzoate

B

chloral
75-87-6

chloral

ethanol
64-17-5

ethanol

1-[(E)-benzylideneamino]-2,2,2-trichloroethanol
43180-42-3

1-[(E)-benzylideneamino]-2,2,2-trichloroethanol

phenyl isothiocyanate
103-72-0

phenyl isothiocyanate

A

benzaldehyde
100-52-7

benzaldehyde

B

chloral
75-87-6

chloral

C

monophenylthiourea
103-85-5

monophenylthiourea

acetaldehyde
75-07-0

acetaldehyde

chloral
75-87-6

chloral

Conditions
ConditionsYield
With water Chlorieren;
With hydrogenchloride; chlorine
With antimony(III) chloride; chlorine
With chlorine at 250℃; under 760.051 Torr; Industry scale;
2-pyrrolidinon
616-45-5

2-pyrrolidinon

chloral
75-87-6

chloral

2,2,2-trichloro-1-(2-oxo-1-aza-1-cyclopentyl)ethanol
7042-60-6

2,2,2-trichloro-1-(2-oxo-1-aza-1-cyclopentyl)ethanol

Conditions
ConditionsYield
In benzene for 2h; Heating;100%
piperidin-2-one
675-20-7

piperidin-2-one

chloral
75-87-6

chloral

1-(2,2,2-Trichloro-1-hydroxy-ethyl)-piperidin-2-one
65101-81-7

1-(2,2,2-Trichloro-1-hydroxy-ethyl)-piperidin-2-one

Conditions
ConditionsYield
In benzene for 2h; Heating;100%
L-Tartaric acid
87-69-4

L-Tartaric acid

chloral
75-87-6

chloral

Conditions
ConditionsYield
With sulfuric acid for 0.5h; Ambient temperature;100%
2,2,2-tribromo-1,3,2-benzodioxaphosphole
3712-44-5

2,2,2-tribromo-1,3,2-benzodioxaphosphole

chloral
75-87-6

chloral

5-bis(1-bromo-2',2',2'-trichloroethoxy)-2,3-benzo-1,4,6-trioxa-7-bromo-8,8,8-trichloro-5-phospha<4>octane
127955-64-0, 135819-35-1

5-bis(1-bromo-2',2',2'-trichloroethoxy)-2,3-benzo-1,4,6-trioxa-7-bromo-8,8,8-trichloro-5-phospha<4>octane

Conditions
ConditionsYield
In dichloromethane at -40 - 25℃; for 4h;100%
With bromine In dichloromethane - 60 to 20 deg C;
2,2,3,3-Tetrafluoropropyl difluorophosphite
131570-94-0

2,2,3,3-Tetrafluoropropyl difluorophosphite

chloral
75-87-6

chloral

bis(1-bromo-2,2,2-trichloroethoxy)difluoro(2,2,3,3-tetrafluoropropoxy)phosphorane
131570-92-8, 135819-38-4, 135819-39-5

bis(1-bromo-2,2,2-trichloroethoxy)difluoro(2,2,3,3-tetrafluoropropoxy)phosphorane

Conditions
ConditionsYield
With bromine In dichloromethane 1.) CH2Cl2, -60 deg C, 2.a) to 15 deg C, 6 h, b) 10-15 deg C;100%
chloral
75-87-6

chloral

2-(2,2,3,3-Tetrafluoro-propoxy)-[1,3,2]dioxaphosphinane
115044-89-8

2-(2,2,3,3-Tetrafluoro-propoxy)-[1,3,2]dioxaphosphinane

1,1,3-trihydroperfluoropropyl-2,2-dichlorovinyl-3-chloropropyl phosphate
115045-01-7

1,1,3-trihydroperfluoropropyl-2,2-dichlorovinyl-3-chloropropyl phosphate

Conditions
ConditionsYield
In dichloromethane at 50℃; for 0.5h;100%
chloral
75-87-6

chloral

N-hydroxybenzenecarboximidamide
613-92-3

N-hydroxybenzenecarboximidamide

O-(2,2,2-Trichloro-1-hydroxyethyl)benzamidoxime
111321-11-0

O-(2,2,2-Trichloro-1-hydroxyethyl)benzamidoxime

Conditions
ConditionsYield
In diethyl ether for 4h; Heating;100%
chloral
75-87-6

chloral

tris(2,2,2-trifluoroethoxy)dicyanophosphorane

tris(2,2,2-trifluoroethoxy)dicyanophosphorane

tris(2,2,2-trofluoroethoxy)bis(1-cyano-2,2,2-trichloroethoxy)phosphorane

tris(2,2,2-trofluoroethoxy)bis(1-cyano-2,2,2-trichloroethoxy)phosphorane

Conditions
ConditionsYield
In dichloromethane at 0 - 10℃;100%
chloral
75-87-6

chloral

dibenzylamine
103-49-1

dibenzylamine

N,N-dibenzylformamide
5464-77-7

N,N-dibenzylformamide

Conditions
ConditionsYield
In chloroform at 10 - 15℃; for 12h;100%
tributyltin methoxide
1067-52-3

tributyltin methoxide

chloral
75-87-6

chloral

1.1.1-Trichlor-2-methoxy-2--ethan
14630-16-1

1.1.1-Trichlor-2-methoxy-2--ethan

Conditions
ConditionsYield
In neat (no solvent) addn. of tributyltin alkoxide to aldehyde (1:1 mole ratio) at 33°C; proved by NMR;100%
In neat (no solvent) addn. of tributyltin alkoxide to aldehyde (1:1 mole ratio) at 33°C; proved by NMR;100%
1:1.1;85-100
tributyltin ethoxide
682-00-8

tributyltin ethoxide

chloral
75-87-6

chloral

2.2.2-Trichlor-1-ethoxy-1-(tributyl-stannoxy)-ethan
21001-96-7

2.2.2-Trichlor-1-ethoxy-1-(tributyl-stannoxy)-ethan

Conditions
ConditionsYield
In tetrachloromethane addn. of tributyltin alkoxide to aldehyde (1:1 mole ratio) at 33°C; proved by NMR;100%
In tetrachloromethane addn. of tributyltin alkoxide to aldehyde (1:1 mole ratio) at 33°C; proved by NMR;100%
tri-n-butyl(cyanomethyl)stannane
17729-59-8

tri-n-butyl(cyanomethyl)stannane

chloral
75-87-6

chloral

<1-Trichlormethyl-2-cyanethoxy>-tributylzinn
17981-10-1

<1-Trichlormethyl-2-cyanethoxy>-tributylzinn

Conditions
ConditionsYield
at room temp. for 16 h;100%
at room temp. for 16 h;100%
1,1-diphenyl-N-(tributylstannyl)methanimine
34982-42-8

1,1-diphenyl-N-(tributylstannyl)methanimine

chloral
75-87-6

chloral

(C4H9)3SnOCH(CCl3)NC(C6H5)2
34982-49-5

(C4H9)3SnOCH(CCl3)NC(C6H5)2

Conditions
ConditionsYield
100%
100%
(N-tributylstannyl)benzenesulfonamide

(N-tributylstannyl)benzenesulfonamide

chloral
75-87-6

chloral

N-(1-Tributylstannyloxy-2-trichlor-ethyl)-benzolsulfonamid

N-(1-Tributylstannyloxy-2-trichlor-ethyl)-benzolsulfonamid

Conditions
ConditionsYield
In neat (no solvent) 1:1.2 mole ratio of (C4H9)3Sn-amine and CCl3CHO at room temp or 55°C; proved by NMR;100%
In tetrachloromethane 1:1.2 mole ratio of (C4H9)3Sn-amine and CCl3CHO at room temp or 55°C; proved by NMR;100%
In tetrachloromethane 1:1.2 mole ratio of (C4H9)3Sn-amine and CCl3CHO at room temp or 55°C; proved by NMR;100%
In neat (no solvent) 1:1.2 mole ratio of (C4H9)3Sn-amine and CCl3CHO at room temp or 55°C; proved by NMR;100%
2-(3,4-dichlorophenyl)-4,4-dimethylsemicarbazide hydrochloride

2-(3,4-dichlorophenyl)-4,4-dimethylsemicarbazide hydrochloride

chloral hydrate
302-17-0

chloral hydrate

A

2-(3,4-dichlorophenyl)-4,4-dimethylsemicarbazone

2-(3,4-dichlorophenyl)-4,4-dimethylsemicarbazone

B

chloral
75-87-6

chloral

Conditions
ConditionsYield
In waterA 66%
B n/a
5-(p-methoxyphenyl)-2-trichloromethyl-1,3,4-oxathiazole
73501-02-7

5-(p-methoxyphenyl)-2-trichloromethyl-1,3,4-oxathiazole

dimethyl acetylenedicarboxylate
762-42-5

dimethyl acetylenedicarboxylate

A

chloral
75-87-6

chloral

B

4-methoxybenzonitrile
874-90-8

4-methoxybenzonitrile

C

dimethyl 3-(p-methoxyphenyl)isothiazole-4,5-dicarboxylate
59291-73-5

dimethyl 3-(p-methoxyphenyl)isothiazole-4,5-dicarboxylate

D

S

S

Conditions
ConditionsYield
In 1,3,5-trimethyl-benzene at 161℃; for 18h;A n/a
B 33%
C 60%
D n/a
thirane
420-12-2

thirane

2,2-dimethyl-4-trichloromethyl-1,3,2-dioxagermenate
96287-65-9

2,2-dimethyl-4-trichloromethyl-1,3,2-dioxagermenate

A

2,2-Dimethyl-2-germa-1-oxa-3-thia-cyclopentan
86553-73-3

2,2-Dimethyl-2-germa-1-oxa-3-thia-cyclopentan

B

chloral
75-87-6

chloral

Conditions
ConditionsYield
at 100°C;;A 45%
B n/a
at 20°C;;A <1
B n/a
oxirane
75-21-8

oxirane

2,2-dimethyl-4-trichloromethyl-1,3,2-dioxagermenate
96287-65-9

2,2-dimethyl-4-trichloromethyl-1,3,2-dioxagermenate

A

dimethyl-2,2 germa-2 dioxolane-1,3
5865-67-8

dimethyl-2,2 germa-2 dioxolane-1,3

B

chloral
75-87-6

chloral

Conditions
ConditionsYield
at 100°C;;A 15%
B n/a
at 20°C;;A <1
B n/a
tetrachloromethane
56-23-5

tetrachloromethane

formaldehyd
50-00-0

formaldehyd

chloral
75-87-6

chloral

Conditions
ConditionsYield
With sulfuryl dichloride at 300℃;
With sulfuryl dichloride at 300℃;
chloral ethyl hemiacetal
515-83-3

chloral ethyl hemiacetal

A

ethanol
64-17-5

ethanol

B

chloral
75-87-6

chloral

Conditions
ConditionsYield
at 157℃;
at 198℃;
ethanol
64-17-5

ethanol

(4-acetylamino-phenoxy)-acetic acid-(2,2,2-trichloro-1-hydroxy-ethylamide)

(4-acetylamino-phenoxy)-acetic acid-(2,2,2-trichloro-1-hydroxy-ethylamide)

A

(4-acetylamino-phenoxy)-acetic acid amide
6033-85-8

(4-acetylamino-phenoxy)-acetic acid amide

B

chloral
75-87-6

chloral

ethanol
64-17-5

ethanol

chloral
75-87-6

chloral

Conditions
ConditionsYield
Chlorierung;
With water; chlorine Bildung des krystallisierten Chloralhydrats;
Chlorieren;
ethyl-(1,2,2,2-tetrachloro-ethyl)-ether
36458-82-9

ethyl-(1,2,2,2-tetrachloro-ethyl)-ether

chloral
75-87-6

chloral

Conditions
ConditionsYield
With sulfuric acid durch Destillieren;
With water at 100℃;
chloral
75-87-6

chloral

acetyl chloride
75-36-5

acetyl chloride

1-azido-2,2,2-trichloroethyl acetate

1-azido-2,2,2-trichloroethyl acetate

Conditions
ConditionsYield
With hydrogen azide In chloroform at -50 - 20℃; for 48h;100%
chloral
75-87-6

chloral

1,3-Dibutyl-2-ethoxy-4,5-dimethyl-2,3-dihydro-1H-[1,3,2]diazaphosphole
141968-97-0

1,3-Dibutyl-2-ethoxy-4,5-dimethyl-2,3-dihydro-1H-[1,3,2]diazaphosphole

1,3-dibutyl-2-[(2,2-dichlorovinyl)oxy]-4,5-dimethyl-Δ4-1,3,2λ5-diazaphospholine 2-oxide

1,3-dibutyl-2-[(2,2-dichlorovinyl)oxy]-4,5-dimethyl-Δ4-1,3,2λ5-diazaphospholine 2-oxide

Conditions
ConditionsYield
In diethyl ether for 24h;99.6%
p-toluidine
106-49-0

p-toluidine

chloral
75-87-6

chloral

2-hydroxyimino-N-p-tolyl-acetamide
1132-40-7

2-hydroxyimino-N-p-tolyl-acetamide

Conditions
ConditionsYield
With hydroxyammonium sulfate; sodium sulfate In water at 60 - 80℃; for 2h;99%
With hydroxylamine hydrochloride; sodium sulfate In water for 0.05h; Condensation; substitution; microwave irradiation;82%
With hydrogenchloride; hydroxylamine hydrochloride; sodium sulfate In water at 90℃; for 0.166667h;27%
4-chloro-aniline
106-47-8

4-chloro-aniline

chloral
75-87-6

chloral

N-(4-chlorophenyl)-2-(hydroxyimino)ethanamide
65798-06-3, 17122-56-4

N-(4-chlorophenyl)-2-(hydroxyimino)ethanamide

Conditions
ConditionsYield
With hydroxyammonium sulfate; sodium sulfate In water at 70 - 80℃; for 3h;99%
With hydroxylamine
With hydrogenchloride; hydroxylamine hydrochloride; sodium sulfate In water at 85℃; for 2.5h;
With hydrogenchloride; hydroxylamine hydrochloride; sodium sulfate In water for 1h; Reflux;
With hydroxylamine hydrochloride; sodium sulfate In water
phenoxymethylpenicillin sulfoxide
4888-90-8

phenoxymethylpenicillin sulfoxide

tert-butylisonitrile
119072-55-8, 7188-38-7

tert-butylisonitrile

chloral
75-87-6

chloral

Penicillin-V-sulfoxid-1'-tert-butylaminocarbonyl-2',2',2'-trichlorethylester
65538-81-0

Penicillin-V-sulfoxid-1'-tert-butylaminocarbonyl-2',2',2'-trichlorethylester

Conditions
ConditionsYield
In tetrahydrofuran; dichloromethane Ambient temperature;99%
1,2,3,6-tertahydrophthalimide
85-40-5

1,2,3,6-tertahydrophthalimide

chloral
75-87-6

chloral

N-(1-Hydroxy-2,2,2-trichloroethyl)-cis-4-cyclohexene-1,2-dicarboximide

N-(1-Hydroxy-2,2,2-trichloroethyl)-cis-4-cyclohexene-1,2-dicarboximide

Conditions
ConditionsYield
In ethanol for 2.5h; Addition; Heating;99%
chloral
75-87-6

chloral

(5E)-2-methyl-6-phenylhex-5-en-3-yn-2-ol
82565-66-0

(5E)-2-methyl-6-phenylhex-5-en-3-yn-2-ol

(E)-1,1,1-Trichloro-6-phenyl-hex-5-en-3-yn-2-ol

(E)-1,1,1-Trichloro-6-phenyl-hex-5-en-3-yn-2-ol

Conditions
ConditionsYield
Stage #1: (5E)-2-methyl-6-phenylhex-5-en-3-yn-2-ol With (o,o'-biphenylenedioxy)methylaluminium In hexane; dichloromethane at 20℃; for 0.5h;
Stage #2: chloral In hexane; dichloromethane at 20℃; for 5h; Meerwein-Ponndorf-Verley alkynylation;
99%
5-bromo-2-pyridinecarboxamide
90145-48-5

5-bromo-2-pyridinecarboxamide

chloral
75-87-6

chloral

5-bromo-N-(2,2,2-trichloro-1-hydroxyethyl)picolinamide
1265593-67-6

5-bromo-N-(2,2,2-trichloro-1-hydroxyethyl)picolinamide

Conditions
ConditionsYield
In 1,4-dioxane at 100℃;99%
In 1,4-dioxane at 100℃;
4-acryloyloxy-2,2,6,6-tetramethylpiperidine-1-oxyl
21270-85-9

4-acryloyloxy-2,2,6,6-tetramethylpiperidine-1-oxyl

chloral
75-87-6

chloral

4-(2-((trichloromethyl)hydroxymethyl)acryloyloxy)-2,2,6,6-tetramethylpiperidine-1-oxyl
1414365-14-2

4-(2-((trichloromethyl)hydroxymethyl)acryloyloxy)-2,2,6,6-tetramethylpiperidine-1-oxyl

Conditions
ConditionsYield
With Quinuclidine; methanol In tetrahydrofuran at 20℃; for 26h; Morita-Baylis-Hillman Alkylation; Inert atmosphere;99%
methylene bis phosphonate de diethyle
63366-56-3

methylene bis phosphonate de diethyle

chloral
75-87-6

chloral

methylenebis(O-ethyl-O-β,β-dichlorovinylphosphonate)
123146-93-0

methylenebis(O-ethyl-O-β,β-dichlorovinylphosphonate)

Conditions
ConditionsYield
In diethyl ether 1) -70 deg C, 2) RT;98%
chloral
75-87-6

chloral

1-methyl-6-phenyl-1H-imidazo[1,2-a]imidazole
37162-79-1

1-methyl-6-phenyl-1H-imidazo[1,2-a]imidazole

2,2,2-Trichloro-1-(7-methyl-2-phenyl-7H-imidazo[1,2-a]imidazol-3-yl)-ethanol
74944-14-2

2,2,2-Trichloro-1-(7-methyl-2-phenyl-7H-imidazo[1,2-a]imidazol-3-yl)-ethanol

Conditions
ConditionsYield
In benzene for 15h; Ambient temperature;98%
chloral
75-87-6

chloral

3-(Methyl-propoxy-phosphinoyloxy)-thiopropionimidic acid propyl ester

3-(Methyl-propoxy-phosphinoyloxy)-thiopropionimidic acid propyl ester

O-propyl-O-<3(N-1-hydroxy-2,2,2-trichloroethyl)imino-3-propylthio>propylmethylphosphonate

O-propyl-O-<3(N-1-hydroxy-2,2,2-trichloroethyl)imino-3-propylthio>propylmethylphosphonate

Conditions
ConditionsYield
In 1,4-dioxane at 15 - 25℃; for 2h;98%
chloral
75-87-6

chloral

3-bromo-1-adamantyl-2'-adamantylphosphine oxide
118154-04-4

3-bromo-1-adamantyl-2'-adamantylphosphine oxide

3-bromo-1-adamantyl-2'-adamantyl-2",2",2"-trichloro-1"-hydroxyethylphosphine oxide

3-bromo-1-adamantyl-2'-adamantyl-2",2",2"-trichloro-1"-hydroxyethylphosphine oxide

Conditions
ConditionsYield
at 80℃; for 2h;98%
chloral
75-87-6

chloral

perfluorobutanoyl diisopropyl phosphite
157402-29-4

perfluorobutanoyl diisopropyl phosphite

diisopropyl 1-perfluorobutanoyloxy-2,2,2-trichloroethylphosphonate

diisopropyl 1-perfluorobutanoyloxy-2,2,2-trichloroethylphosphonate

Conditions
ConditionsYield
at 20℃;98%

Chloral Consensus Reports

Reported in EPA TSCA Inventory.

Chloral Standards and Recommendations

DOT Classification:  6.1; Label: Poison

Chloral Specification

The Chloral, with the CAS registry number 75-87-6, is also known as Acetaldehyde, trichloro-. Its EINECS registry number is 200-911-5. This chemical's molecular formula is C2HCl3O and molecular weight is 147.38774. Its IUPAC name is called Trichloroethanal. This chemical's classification codes are Drug / Therapeutic Agent; Mutation Data; Tumor Data.

Physical properties of Chloral: (1)ACD/LogP: 1.61; (2)ACD/LogD (pH 5.5): 1.61; (3)ACD/LogD (pH 7.4): 1.61; (4)ACD/BCF (pH 5.5): 9.85; (5)ACD/BCF (pH 7.4): 9.85; (6)ACD/KOC (pH 5.5): 178.99; (7)ACD/KOC (pH 7.4): 178.99; (8)#H bond acceptors: 1; (9)Index of Refraction: 1.471; (10)Molar Refractivity: 26.01 cm3; (11)Molar Volume: 93 cm3; (12)Surface Tension: 37.9 dyne/cm; (13)Density: 1.583 g/cm3; (14)Flash Point: 14.9 °C; (15)Enthalpy of Vaporization: 33.73 kJ/mol; (16)Boiling Point: 97.8 °C at 760 mmHg; (17)Vapour Pressure: 41.1 mmHg at 25°C.

Preparation: Chloral can be produced by chlorination of ethanol, as reported in 1832 by Justus von Liebig. Chloral can also be produced by the reaction of acetaldehyde with chlorine by replacement of the hydrogen atoms of the methyl group. Chlorine reacts with acetaldehyde at room temperature to give mono-chloroacetaldehyde. Increasing the temperature to 70 to 80 °C gives dichloroacetaldehyde, and at a temperature of 80 to 90 °C trichloroacetadehyde, (chloral) is formed.

CH3CH=O + Cl2 → CH2ClCH=O + HCl
CH2ClCH=O + Cl2 → CHCl2CH=O + HCl
CHCl2CH=O + Cl2 → CCl3CH=O + HCl

Uses of Chloral: This chemical is widely used as sedative and hypnotic substance. Chloral is also used to form chloroform by treating it with sodium hydroxide. It is treated with chlorobenzene in the presence of a catalytic amount of sulfuric acid:

Cl3CCHO + 2 C6H5Cl → Cl3CCH(C6H4Cl)2 + H2O

When you are using this chemical, please be cautious about it as the following:
This chemical that at low levels can cause damage to health. It is irritating to eyes, respiratory system and skin. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. Whenever you will contact it, please wear suitable protective clothing and gloves.

You can still convert the following datas into molecular structure:
(1)Canonical SMILES: C(=O)C(Cl)(Cl)Cl
(2)InChI: InChI=1S/C2HCl3O/c3-2(4,5)1-6/h1H
(3)InChIKey: HFFLGKNGCAIQMO-UHFFFAOYSA-N

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LC50 inhalation 5900mg/m3/4H (5900mg/m3) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA
National Technical Information Service. Vol. OTS0571197,
mammal (species unspecified) LD50 oral 710mg/kg (710mg/kg)   Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 39(4), Pg. 86, 1974.
mouse LD50 intraperitoneal 600mg/kg (600mg/kg)   Bollettino Chimico Farmaceutico. Vol. 111, Pg. 293, 1972.
rat LC50 inhalation 440mg/m3/4H (440mg/m3) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
National Technical Information Service. Vol. OTS0533728

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