D-2-Phenylglycine supplier

Name
D-2-Phenylglycine
EINECS 212-876-3
CAS No. 875-74-1
Article Data90
CAS DataBase
Density 1.246 g/cm³
Solubility 0.3 g/100mL in water
Melting Point 302 °C (dec.)(lit.)
Formula C₈H₉NO₂
Boiling Point 288.7 °C at 760 mmHg
Molecular Weight 151.165
Flash Point 128.4 °C
Transport Information
Appearance white crystalline powder
Safety 22-24/25-45-36/37/39-26
Risk Codes 23/24/25-36/37/38
Molecular Structure
Hazard Symbols T
Synonyms Benzeneaceticacid, a-amino-, (R)-;(R)-a-Phenylglycine;D-(-)-2-Phenylglycine;D-(-)-Aminophenylacetic acid;D-(-)-Phenylglycine;D-(-)-a-Aminophenylacetic acid;D-(-)-a-Phenylglycine;D-2-Phenylglycine;D-C-Phenylglycine;D-Phenylglycine;D-a-Aminophenylacetic acid;Glycine,2-phenyl-, D- (8CI);(-)-(R)-Phenylglycine;(-)-Phenylglycine;(2R)-Amino-2-phenylethanoic acid;(R)-(-)-2-Phenylglycine;(R)-2-Amino-2-(phenyl)ethanoic acid;(R)-2-Amino-2-phenylacetic acid;(R)-2-Phenylglycine;(R)-Phenylglycine;
PSA 63.32000
LogP 1.47130

Synthetic route

: 29125-25-5
(R)-2-azido-2-phenylacetic acid

: 875-74-1
(R)-phenylglycine

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal In water; acetic acid under 760 Torr; for 3h;	97%

: potassium cyanide

: 100-52-7
benzaldehyde

: 875-74-1
(R)-phenylglycine

Conditions

Conditions	Yield
With nitrilase AY487533 In aq. acetate buffer at 20℃; for 1h; pH=8; Enzymatic reaction; enantioselective reaction;	96.5%

: (R)-2-benzyloxycarbonylamino-2-phenylacetonitrile

: 875-74-1
(R)-phenylglycine

Conditions

Conditions	Yield
With hydrogenchloride; water In water at 110℃; for 3h; optical yield given as %ee;	94%

: 33125-05-2
Boc-D-Phg-OH

: 875-74-1
(R)-phenylglycine

Conditions

Conditions	Yield
With trifluoroacetic acid for 0.333333h;	89%
With hydrogenchloride; Dowex 50*8 1.) THF, room temperature, 2 h.; Yield given. Multistep reaction;

: 551-16-6
6-Aminopenicillanic Acid

: 700-63-0, 6485-52-5, 6485-67-2, 58429-87-1
(R)-phenylglycine amide

A: 875-74-1
(R)-phenylglycine

B: 69-53-4
ampicillin

Conditions

Conditions	Yield
With A. faecalis; immobilised penicillin acylase (EC 3.5.1.11) In water; acetonitrile at 0℃; Product distribution; Kinetics; Further Variations:; Solvents; reusing run; Enzymatic reaction;	A n/a B 86%

...Expand

: 186801-10-5
N-(2,4,6-trimethyl-benzenesulfonyl)-D-phenylglycine

: 875-74-1
(R)-phenylglycine

Conditions

Conditions	Yield
With sodium naphthalenide In 1,2-dimethoxyethane at -40℃; for 0.5h;	78%

: 188772-75-0
(R)-(furan-2-yl)(phenyl)methanamine

: 875-74-1
(R)-phenylglycine

Conditions

Conditions	Yield
With ozone In methanol at -78℃; for 0.25h;	78%

: 14257-84-2, 15962-46-6, 29633-99-6, 42429-20-9
N-acetyl-α-phenylglycine

: 875-74-1
(R)-phenylglycine

Conditions

Conditions	Yield
With water at 30℃; for 26h; D-aminoacylase from Streptomyces tuirus IFO 13418;	74%

: 611-71-2, 611-72-3, 17199-29-0, 90-64-2
MANDELIC ACID

: 875-74-1
(R)-phenylglycine

Conditions

Conditions	Yield
With D-glucose; ammonia; ammonium chloride In aq. phosphate buffer at 30℃; for 24h; pH=8; Catalytic behavior; Reagent/catalyst; Microbiological reaction; Green chemistry; Enzymatic reaction; enantioselective reaction;	71%

: 133545-89-8
[(1R)-2-(benzyloxy)-2-oxo-1-phenylethyl]ammonium 4-methyl-1-benzensulfonate

: 875-74-1
(R)-phenylglycine

Conditions

Conditions	Yield
With hydrogenchloride Heating;	69%

: 292638-84-7
styrene

: 875-74-1
(R)-phenylglycine

Conditions

Conditions	Yield
With D-glucose; oleic acid ethyl ester; ammonia; oxygen; ammonium chloride In aq. phosphate buffer at 30℃; for 24h; pH=8; Catalytic behavior; Reagent/catalyst; Microbiological reaction; Green chemistry; Enzymatic reaction; enantioselective reaction;	62%
Multi-step reaction with 6 steps 1: styrene monooxygenase; NADPH; oxygen / Enzymatic reaction 2: epoxide hydrolase; water / Enzymatic reaction 3: alcohol dehydrogenase / Enzymatic reaction 4: aldehyde dehydrogenase; NAD / Enzymatic reaction 5: recombinant Escherichia coli expressing SMDH / aq. phosphate buffer / 0.5 h / 30 °C / pH 8 / Microbiological reaction; Enzymatic reaction 6: recombinant Escherichia coli DL39 (DE3) expressing DpgAT; L-glutamate / aq. phosphate buffer / 5 h / 30 °C / pH 8 / Microbiological reaction; Enzymatic reaction View Scheme

Yield

With D-glucose; oleic acid ethyl ester; ammonia; oxygen; ammonium chloride In aq. phosphate buffer at 30℃; for 24h; pH=8; Catalytic behavior; Reagent/catalyst; Microbiological reaction; Green chemistry; Enzymatic reaction; enantioselective reaction;

62%

Multi-step reaction with 6 steps
1: styrene monooxygenase; NADPH; oxygen / Enzymatic reaction
2: epoxide hydrolase; water / Enzymatic reaction
3: alcohol dehydrogenase / Enzymatic reaction
4: aldehyde dehydrogenase; NAD / Enzymatic reaction
5: recombinant Escherichia coli expressing SMDH / aq. phosphate buffer / 0.5 h / 30 °C / pH 8 / Microbiological reaction; Enzymatic reaction
6: recombinant Escherichia coli DL39 (DE3) expressing DpgAT; L-glutamate / aq. phosphate buffer / 5 h / 30 °C / pH 8 / Microbiological reaction; Enzymatic reaction
View Scheme

: 63-91-2
L-phenylalanine

: 875-74-1
(R)-phenylglycine

Conditions

Conditions	Yield
With D-glucose; oleic acid ethyl ester; ammonia; ammonium chloride In aq. phosphate buffer at 30℃; for 24h; pH=8; Catalytic behavior; Reagent/catalyst; Microbiological reaction; Green chemistry; Enzymatic reaction; enantioselective reaction;	53%
Multi-step reaction with 3 steps 1: phenylalanine ammonia lyase / Enzymatic reaction 2: pheylacrylic acid decarboxylase / Enzymatic reaction 3: ammonia; ammonium chloride; D-glucose; oleic acid ethyl ester; oxygen / aq. phosphate buffer / 24 h / 30 °C / pH 8 / Microbiological reaction; Green chemistry; Enzymatic reaction View Scheme
Multi-step reaction with 8 steps 1: phenylalanine ammonia lyase / Enzymatic reaction 2: pheylacrylic acid decarboxylase / Enzymatic reaction 3: styrene monooxygenase; NADPH; oxygen / Enzymatic reaction 4: epoxide hydrolase; water / Enzymatic reaction 5: alcohol dehydrogenase / Enzymatic reaction 6: aldehyde dehydrogenase; NAD / Enzymatic reaction 7: recombinant Escherichia coli expressing SMDH / aq. phosphate buffer / 0.5 h / 30 °C / pH 8 / Microbiological reaction; Enzymatic reaction 8: recombinant Escherichia coli DL39 (DE3) expressing DpgAT; L-glutamate / aq. phosphate buffer / 5 h / 30 °C / pH 8 / Microbiological reaction; Enzymatic reaction View Scheme

: 24461-61-8
(R)-Phenylglycine methyl ester

: 875-74-1
(R)-phenylglycine

Conditions

Conditions	Yield
With potassium tert-butylate In tetrahydrofuran at 0℃; for 0.25h; Hydrolysis;	35%

: 4755-72-0, 39266-56-3
Chloro-phenyl-acetic acid

: 875-74-1
(R)-phenylglycine

Conditions

Conditions	Yield
With ammonia; benzonitrile
With ammonia
With ammonia; acetonitrile
With n-heptan1ol; ammonia

: 700-63-0, 6485-52-5, 6485-67-2, 58429-87-1
(R)-phenylglycine amide

: 875-74-1
(R)-phenylglycine

Conditions

Conditions	Yield
With hydrogen bromide
Multi-step reaction with 2 steps 1: 42 percent / Alcaligenes faecalis penicillin acylase; potassium hydroxide / H2O / 0.28 h / 25 °C / pH 10 2: Alkaligenes faecalis penicillin acylase / 25 °C / pH 7.5 View Scheme

: 10419-67-7
N-[(2S)-(benzoylamino)(phenyl)]ethanoic acid

: 875-74-1
(R)-phenylglycine

Conditions

Conditions	Yield
With hydrogenchloride

: 60686-79-5
(R)-2-bromo-2-phenylacetic acid

: 875-74-1
(R)-phenylglycine

Conditions

Conditions	Yield
With ammonia; acetonitrile

: 28290-68-8
(R)-(2-chloro-acetylamino)-phenyl-acetic acid

: 875-74-1
(R)-phenylglycine

Conditions

Conditions	Yield
With hydrogenchloride

: 50859-90-0
(R)-D-mandeloylamino-phenyl-acetic acid

: 875-74-1
(R)-phenylglycine

Conditions

Conditions	Yield
With hydrogenchloride

: 3144-16-9
(1S)-10-camphorsulfonic acid

: 2835-06-5
phenylglycin

: 875-74-1
(R)-phenylglycine

: 2835-06-5
phenylglycin

: 875-74-1
(R)-phenylglycine

Conditions

Conditions	Yield
With (1S)-10-camphorsulfonic acid

: 89-24-7
5-phenylimidazolidine-2,4-dione

: 875-74-1
(R)-phenylglycine

Conditions

Conditions	Yield
With potassium phosphate buffer; Pseudomonas sp. AJ-11220 In various solvent(s) at 30℃; for 2h; pH 8.0; enzymatic reaction;
With potassium phosphate buffer; Pseudomonas sp. AJ-11220 In various solvent(s) at 30℃; for 2h;

: 25327-36-0
(Z)-2-(hydroxyimino)-2-phenylacetic acid

A: 2935-35-5
(S)-2-phenylglycine

B: 875-74-1
(R)-phenylglycine

Conditions

Conditions	Yield
With buffered acetic acid; strychnidin-10-one; mercury Product distribution; var. strychnine concentrations, other cathodic potentials (E): -1.05, -1.15, -1.30 V (SCE); object of study: optical yield;

: 82264-50-4
N-carbamoyl-D,L-phenylglycine

: 875-74-1
(R)-phenylglycine

Conditions

Conditions	Yield
With potassium phosphate buffer; Pseudomonas sp. AJ-11220 In various solvent(s) at 30℃; for 2h;
With potassium phosphate buffer; Pseudomonas sp. AJ-11220 In various solvent(s) at 30℃; for 2h; pH 7.5; enzymatic reaction;

: (R)-2-Amino-1-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]dec-4-yl)-2-phenyl-ethanone

: 875-74-1
(R)-phenylglycine

Conditions

Conditions	Yield
With lithium hydroxide; ion exchange 1.) THF; Yield given. Multistep reaction;

: 803648-97-7
Phenylglycine p-nitrophenyl ester

A: 2935-35-5
(S)-2-phenylglycine

B: 875-74-1
(R)-phenylglycine

Conditions

Conditions	Yield
With (R)-<methyl>pyridine; copper(II) ion In various solvent(s) at 25℃; Rate constant; enantioselectivity of cleavage; other chiral ligands;

: 67-66-3
chloroform

: 100-52-7
benzaldehyde

A: 2935-35-5
(S)-2-phenylglycine

B: 875-74-1
(R)-phenylglycine

Conditions

Conditions	Yield
With potassium hydroxide; ammonia; (+)-(1S,2R)-N-hexadecyl-N-methylephedrinium bromide; lithium chloride In ethanol Product distribution; 5 deg C, 4 h, RT, overnight; asymmetric induction;

...Expand

: 119825-43-3
(R)-2-Amino-N-tert-butyl-2-phenyl-acetamide; hydrochloride

: 875-74-1
(R)-phenylglycine

Conditions

Conditions	Yield
With hydrogenchloride In water at 80℃; Yield given;

: 111524-98-2
(2S)-2-phenyl-2-(tosylamino)acetic acid

A: 2935-35-5
(S)-2-phenylglycine

B: 875-74-1
(R)-phenylglycine

Conditions

Conditions	Yield
With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; samarium diiodide In tetrahydrofuran for 9h; Heating; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

: 71849-99-5
(+/-)-α-phenylglycine hydrochloride

: 875-74-1
(R)-phenylglycine

: 67-56-1
methanol

: 875-74-1
(R)-phenylglycine

: 19883-41-1
D-phenylglycine methyl ester hydrochloride

Conditions

Conditions	Yield
With thionyl chloride for 2h; Heating;	100%
With thionyl chloride In methanol at 20℃; Cooling with ice;	99%
With thionyl chloride at 0 - 75℃; for 2h;	98.9%

: 50-00-0
formaldehyd

: 875-74-1
(R)-phenylglycine

: 29810-09-1
(R)-2-(dimethylamino)-2-phenylacetic acid

Conditions

Conditions	Yield
With hydrogenchloride; hydrogen; 5% Pd(II)/C(eggshell) In methanol; water under 1810.07 - 2068.65 Torr; for 4h;	100%
With hydrogenchloride; hydrogen; 5%-palladium/activated carbon In methanol; water under 1810.07 - 2068.65 Torr; for 4h;	100%
With hydrogenchloride; hydrogen; 5%-palladium/activated carbon In methanol; water under 1810.07 - 2068.65 Torr; for 4h;	100%

: 24424-99-5
di-tert-butyl dicarbonate

: 875-74-1
(R)-phenylglycine

: 33125-05-2
Boc-D-Phg-OH

Conditions

Conditions	Yield
With sodium hydroxide In tert-butyl alcohol at 20℃; for 1h; Inert atmosphere;	100%
With potassium hydrogencarbonate In tetrahydrofuran; water for 18h;	99%
With sodium hydroxide	96%

: 64-18-6
formic acid

: 875-74-1
(R)-phenylglycine

: 10419-71-3
(2R)-2-(N-formyl)amino-2-phenylacetic acid

Conditions

Conditions	Yield
With acetic anhydride at 20℃; for 1h;	100%

: 875-74-1
(R)-phenylglycine

: 2937-50-0
Allyl chloroformate

: 104128-14-5
(2R)-{[(allyloxy)carbonyl]amino}(phenyl)acetic acid

Conditions

Conditions	Yield
With sodium hydroxide In tetrahydrofuran at 0℃; for 0.25h;	99%

: 875-74-1
(R)-phenylglycine

: 1623-93-4
4-diphenylsulfonyl chloride

: 193808-16-1
N-(biphenyl-4-sulfonyl)-D-phenylglycine

Conditions

Conditions	Yield
With sodium hydroxide In diethyl ether at 20℃; for 16h;	99%

: 2824-46-6
benzothiazole-2-sulfonyl chloride

: 875-74-1
(R)-phenylglycine

: 184222-92-2
(R)-(Benzothiazole-2-sulfonylamino)-phenyl-acetic acid

Conditions

Conditions	Yield
With sodium hydroxide at 10℃; for 10h;	97%

: 875-74-1
(R)-phenylglycine

: 4885-81-8
D-(-)-α-(m-nitrophenyl)glycine

Conditions

Conditions	Yield
With sulfuric acid; nitric acid at 50℃; for 6.5h; Cooling with ice;	96.8%
Stage #1: (R)-phenylglycine With sulfuric acid; nitric acid In water at 0℃; for 3h; Stage #2: With ammonia In water	62%

: 875-74-1
(R)-phenylglycine

: 60686-79-5
(R)-2-bromo-2-phenylacetic acid

Conditions

Conditions	Yield
With hydrogen bromide; sodium nitrite at 0℃; for 2h;	96%
Stage #1: (R)-phenylglycine With sulfuric acid; potassium bromide In water Stage #2: With sodium nitrite In water at 0 - 20℃; for 2.5h;
With sulfuric acid; potassium bromide; sodium nitrite In water

: 85-44-9
phthalic anhydride

: 875-74-1
(R)-phenylglycine

: 15962-42-2
(R)-2-(1,3-dioxoisoindolin-2-yl)-2-phenylacetic acid

Conditions

Conditions	Yield
With triethylamine In toluene at 130℃; for 3h; Dean-Stark;	96%
With acetic acid at 120℃; for 12h; Reflux;

: 875-74-1
(R)-phenylglycine

: 14328-52-0
(R)-2-amino-2-cyclohexyl acetic acid

Conditions

Conditions	Yield
With hydrogenchloride; hydrogen In water; isopropyl alcohol at 50 - 60℃; for 6 - 8h;	95.8%
With hydrogen; platinum(IV) oxide In acetic acid Ambient temperature;	91%
With hydrogenchloride; hydrogen; rhodium under 38000 Torr; for 240h;	79%
With hydrogenchloride; platinum at 70℃; Hydrogenation;
With hydrogenchloride; hydrogen; platinum(IV) oxide In ethanol

: 64-17-5
ethanol

: 875-74-1
(R)-phenylglycine

: 17609-48-2
(R)-2-phenylglycine ethyl ester hydrochloride

Conditions

Conditions	Yield
With thionyl chloride at 0 - 20℃; Reflux; Inert atmosphere;	95%
With hydrogenchloride
With thionyl chloride at 20℃;

: 875-74-1
(R)-phenylglycine

: 104-15-4
toluene-4-sulfonic acid

: 84860-34-4
L-(+)-α-Phenylglycine p-toluenesulfonate salt

Conditions

Conditions	Yield
In 1,2-dimethoxyethane; dichloromethane at 40℃; for 2h;	95%

: 875-74-1
(R)-phenylglycine

: 104-15-4
toluene-4-sulfonic acid

: 84860-33-3
D-(-)-α-Phenylglycine p-toluenosulfonate salt

Conditions

Conditions	Yield
In 1,2-dimethoxyethane; dichloromethane at 40℃; for 2h;	95%

: 875-74-1
(R)-phenylglycine

: 684-16-2
Hexafluoroacetone

: 202273-33-4
(R)-4-Phenyl-2,2-bis-trifluoromethyl-oxazolidin-5-one

Conditions

Conditions	Yield
	95%

: 875-74-1
(R)-phenylglycine

: 104-15-4
toluene-4-sulfonic acid

: 100-51-6
benzyl alcohol

: 133545-89-8
[(1R)-2-(benzyloxy)-2-oxo-1-phenylethyl]ammonium 4-methyl-1-benzensulfonate

Conditions

Conditions	Yield
In cyclohexane; water for 4h; Dean-Stark; Reflux;	95%
With water In toluene Heating;	89%

...Expand

: 875-74-1
(R)-phenylglycine

: 103-72-0
phenyl isothiocyanate

: 1042303-80-9
(R)-phenyl-(3'-phenyl-thioureido)acetic acid

Conditions

Conditions	Yield
With sodium hydroxide In tetrahydrofuran; water at 20℃; for 24h;	95%
Stage #1: (R)-phenylglycine With sodium hydroxide In tetrahydrofuran; water for 0.25h; Stage #2: phenyl isothiocyanate In tetrahydrofuran; water at 20℃;

: 875-74-1
(R)-phenylglycine

: 56613-80-0
(R)-Phenylglycinol

Conditions

Conditions	Yield
Stage #1: (R)-phenylglycine With sodium tetrahydroborate; iodine In tetrahydrofuran at 64℃; for 18h; Stage #2: With methanol In tetrahydrofuran at 20℃;	94%
With lithium borohydride; chloro-trimethyl-silane In tetrahydrofuran at 0 - 20℃; for 49h;	93%
With lithium aluminium tetrahydride In tetrahydrofuran for 20h; Heating;	92%

: 875-74-1
(R)-phenylglycine

: 58632-95-4
2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile

: 33125-05-2
Boc-D-Phg-OH

Conditions

Conditions	Yield
With triethylamine In 1,4-dioxane; water for 18h;	94%

: 875-74-1
(R)-phenylglycine

: 23165-29-9
3,5-bistrifluoromethylphenylisothiocyanate

: 1042303-85-4
(R)-[3'-(3,5-bis-trifluoromethyl)phenyl-thioureido]-phenyl acetic acid

Conditions

Conditions	Yield
With sodium hydroxide In tetrahydrofuran; water at 20℃; for 24h;	94%
Stage #1: 3,5-bistrifluoromethylphenylisothiocyanate With sodium hydroxide In tetrahydrofuran; water for 0.25h; Stage #2: (R)-phenylglycine In tetrahydrofuran; water at 20℃;

: 12093-10-6
ferrocenecarboxaldehyde

: 875-74-1
(R)-phenylglycine

: 1310-73-2
sodium hydroxide

: sodium (R)-2-[(ferrocenylmethylidene)amino]-2-phenyl-ethanoate

Conditions

Conditions	Yield
With molecular sieve In methanol; ethanol under N2; aq. NaOH added to amino acid, soln. stirred (room temp., 5 min), soln. concd. (vac.), residue dried at 60°C (vac., 16 h), molecular sieves (4 Angstroem), ferrocenecarboxaldehyde and EtOH/MeOH added, mixt. stirred (room temp., 16 h); molecular sieves filtered off, filtrate concd. under vac., residue suspd. in pentane, solid filtered off, washed with pentane, dried under vac.;	94%

Yield

With molecular sieve In methanol; ethanol under N2; aq. NaOH added to amino acid, soln. stirred (room temp., 5 min), soln. concd. (vac.), residue dried at 60°C (vac., 16 h), molecular sieves (4 Angstroem), ferrocenecarboxaldehyde and EtOH/MeOH added, mixt. stirred (room temp., 16 h); molecular sieves filtered off, filtrate concd. under vac., residue suspd. in pentane, solid filtered off, washed with pentane, dried under vac.;

94%

...Expand

: 875-74-1
(R)-phenylglycine

: 108-24-7
acetic anhydride

: 14257-84-2, 15962-46-6, 29633-99-6, 42429-20-9
(R)-(-)-N-acetylphenylglycine

Conditions

Conditions	Yield
With sodium hydroxide In water at 0℃; for 6h; pH=11-12; Temperature;	93.4%
Stage #1: (R)-phenylglycine With sodium hydroxide In water for 0.0333333h; Stage #2: acetic anhydride In water at 20℃; for 0.25h; Stage #3: With hydrogenchloride In water pH=1;	80%
With sodium hydroxide In water at 0 - 5℃; pH=5;	32%
With sodium hydroxide In water at 0 - 5℃; for 0.5h;
In water at 70℃; for 0.5h;

: 875-74-1
(R)-phenylglycine

: 39637-74-6
(1S)-(-)-camphanic chloride

: N-((1S)-Camphanoyl)-(R)-phenylglycin

Conditions

Conditions	Yield
In tetrahydrofuran for 288h;	93%

: 875-74-1
(R)-phenylglycine

: C9H6Cl3N3O3

: 26553-34-4
N-trichloroethoxycarbonyl-D-phenylglycine

Conditions

Conditions	Yield
With pyridine; sodium hydroxide In acetone at 4℃; for 2h;	93%

: 875-74-1
(R)-phenylglycine

: 70-34-8
2,4-Dinitrofluorobenzene

: N(2,4-dinitrophenyl)-(R)-phenylglycine

Conditions

Conditions	Yield
With sodium hydrogencarbonate In water at 80℃; for 0.00972222h; Substitution; microwave irradiation;	93%

: 383-63-1
ethyl trifluoroacetate,

: 875-74-1
(R)-phenylglycine

: 5042-71-7
(-)-(R)-N-trifluoroacetylphenylglycine

Conditions

Conditions	Yield
Stage #1: (R)-phenylglycine With N,N,N',N'-tetramethylguanidine In methanol for 0.0833333h; Stage #2: ethyl trifluoroacetate, In methanol at 20℃; for 30h;	93%
With 1,1,3,3-tetramethylguanidine In methanol at 20℃; for 24h;	93%

: 875-74-1
(R)-phenylglycine

: 501-53-1
benzyl chloroformate

: 17609-52-8
Z-D-phenylglycine

Conditions

Conditions	Yield
With sodium hydroxide for 0.166667h;	92%
With sodium hydroxide	88%
With sodium hydroxide at 0℃; for 1h;	82%

D-2-Phenylglycine Chemical Properties

IUPAC Name: (2R)-2-azaniumyl-2-phenylacetate
Empirical Formula: C₈H₉NO₂
Molecular Weight: 151.1626g/mol
EINECS: 212-876-3
Structure of D-2-Phenylglycine (CAS NO.875-74-1):

Index of Refraction: 1.589
Molar Refractivity: 40.9 cm³
Molar Volume: 121.3 cm³
Polarizability: 16.21×10^-24cm³
Surface Tension: 57 dyne/cm
Density: 1.246 g/cm³
Flash Point: 128.4 °C
Enthalpy of Vaporization: 55.75 kJ/mol
Melting Point: 302 °C (dec.)(lit.)
Boiling Point: 288.7 °C at 760 mmHg
Vapour Pressure: 0.00107 mmHg at 25°C
Water Solubility: 0.3g/100mL
Product Categories: GLYCINESCAFFOLD;Pharmaceutical Intermediates;Amino ACIDS SERIES;Phenylglycine [Phg];Unusual Amino Acids;Amino Acids
Canonical SMILES: C1=CC=C(C=C1)C(C(=O)[O-])[NH3+]
Isomeric SMILES: C1=CC=C(C=C1)[C@H](C(=O)[O-])[NH3+]
InChI: InChI=1S/C8H9NO2/c9-7(8(10)11)6-4-2-1-3-5-6/h1-5,7H,9H2,(H,10,11)/t7-/m1/s1
InChIKey: ZGUNAGUHMKGQNY-SSDOTTSWSA-N

D-2-Phenylglycine Safety Profile

Hazard Codes: Toxic T
Risk Statements: 23/24/25-36/37/38
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 22-24/25-45-36/37/39-26
S22:Do not breathe dust.
S24/25:Avoid contact with skin and eyes.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany: 3
HS Code: 29224995

D-2-Phenylglycine Specification

D-2-Phenylglycine , its cas register number is 875-74-1. It also can be called Benzeneacetic acid, alpha-amino-, (alphaR)- ;
D-(-)-alpha-Phenylglycine . D-2-Phenylglycine (CAS NO.875-74-1) is a white crystalline powder.

Product Name

D-2-Phenylglycine

Synthetic route

D-2-Phenylglycine Chemical Properties

D-2-Phenylglycine Safety Profile

D-2-Phenylglycine Specification

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