Product Name

  • Name

    Dimethyl isophthalate

  • EINECS 215-951-9
  • CAS No. 1459-93-4
  • Article Data97
  • CAS DataBase
  • Density 1.175 g/cm3
  • Solubility insoluble in water
  • Melting Point 64-68 °C
  • Formula C10H10O4
  • Boiling Point 285 °C at 760 mmHg
  • Molecular Weight 194.187
  • Flash Point 148 °C
  • Transport Information
  • Appearance white to off-white flakes or crystalline powder
  • Safety 26-36
  • Risk Codes 36
  • Molecular Structure Molecular Structure of 1459-93-4 (Dimethyl isophthalate)
  • Hazard Symbols IrritantXi
  • Synonyms 1,3-Benzenedicarboxylicacid, dimethyl ester (9CI);Isophthalic acid, dimethyl ester (6CI,8CI);1,3-Di(methoxycarbonyl)benzene;Dimethyl 1,3-benzenedicarboxylate;Dimethyl m-phthalate;Methyl 3-carbomethoxybenzoate;Morflex 1129;NSC 15313;
  • PSA 52.60000
  • LogP 1.25980

Synthetic route

methanol
67-56-1

methanol

isophthalic acid
121-91-5

isophthalic acid

dimethyl Isophthalate
1459-93-4

dimethyl Isophthalate

Conditions
ConditionsYield
With boron trifluoride at 65℃; for 0.333333h;100%
With thionyl chloride at 20℃; for 72h;95.7%
With 4-methyl-morpholine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride for 3h;92%
phosgene
75-44-5

phosgene

isophthalic acid
121-91-5

isophthalic acid

A

dimethyl Isophthalate
1459-93-4

dimethyl Isophthalate

B

benzene-1,3-dicarbonyl dichloride
99-63-8

benzene-1,3-dicarbonyl dichloride

Conditions
ConditionsYield
With pyridine In dichloromethaneA n/a
B 100%
...Expand
dimethyl 5-pivaloxyisophthalate
1283160-97-3

dimethyl 5-pivaloxyisophthalate

dimethyl Isophthalate
1459-93-4

dimethyl Isophthalate

Conditions
ConditionsYield
With bis(1,5-cyclooctadiene)nickel(0); (dimethoxy)methylsilane; tricyclohexylphosphine In toluene at 80℃; for 12h; Inert atmosphere;99%
methanol
67-56-1

methanol

1,3-bis-trichloromethyl-benzene
881-99-2

1,3-bis-trichloromethyl-benzene

dimethyl Isophthalate
1459-93-4

dimethyl Isophthalate

Conditions
ConditionsYield
at 20℃; for 6h; UV-irradiation;99%
5-iodo-isophthalic acid dimethyl ester
51839-15-7

5-iodo-isophthalic acid dimethyl ester

dimethyl Isophthalate
1459-93-4

dimethyl Isophthalate

Conditions
ConditionsYield
With Ac-Cys-OMe; bismuth(III) oxide; N-ethyl-N,N-diisopropylamine In dichloromethane for 48h; Irradiation;96%
dimethyl 5-bromoisophthalate
51760-21-5

dimethyl 5-bromoisophthalate

dimethyl Isophthalate
1459-93-4

dimethyl Isophthalate

Conditions
ConditionsYield
With formic acid; tributyl-amine; 10-phenyl-10H-phenothiazine In acetonitrile at 20℃; for 24h; Inert atmosphere; UV-irradiation;94%
methanol
67-56-1

methanol

carbon monoxide
201230-82-2

carbon monoxide

3-Fluorosulfonyloxy-benzoic acid methyl ester
141694-38-4

3-Fluorosulfonyloxy-benzoic acid methyl ester

dimethyl Isophthalate
1459-93-4

dimethyl Isophthalate

Conditions
ConditionsYield
With triethylamine; palladium diacetate; 1,3-bis-(diphenylphosphino)propane In dimethyl sulfoxide under 760 Torr; a) room temperature, 15 min, b) 60 deg C, 2 h;92%
...Expand
methanol
67-56-1

methanol

Isophthalaldehyde
626-19-7

Isophthalaldehyde

dimethyl Isophthalate
1459-93-4

dimethyl Isophthalate

Conditions
ConditionsYield
With Oxone; indium(III) triflate for 1.5h; Reflux;92%
With Oxone at 60℃; for 0.666667h; Sonication;90%
Stage #1: methanol; Isophthalaldehyde With pyridine at 20℃; for 0.0833333h;
Stage #2: With N-Bromosuccinimide at 20℃; for 9h;		100 %Chromat.
3-(5,5-dimethyl-1,3,2-dioxaborinanyl)-1-methoxycarbonylbenzene
585524-77-2

3-(5,5-dimethyl-1,3,2-dioxaborinanyl)-1-methoxycarbonylbenzene

di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

methyl iodide
74-88-4

methyl iodide

dimethyl Isophthalate
1459-93-4

dimethyl Isophthalate

Conditions
ConditionsYield
Stage #1: 3-(5,5-dimethyl-1,3,2-dioxaborinanyl)-1-methoxycarbonylbenzene; di-tert-butyl dicarbonate With 4,4'-dimethyl-2,2'-bipyridines; lithium methanolate; copper(l) chloride In N,N-dimethyl acetamide at 30℃; for 6h; Inert atmosphere; Schlenk technique;
Stage #2: methyl iodide In N,N-dimethyl acetamide at 30℃; for 2h; Schlenk technique;		91%
...Expand
methanol
67-56-1

methanol

Isophthalaldehyde
626-19-7

Isophthalaldehyde

A

dimethyl Isophthalate
1459-93-4

dimethyl Isophthalate

B

m-formylphenyl benzoic acid
619-21-6

m-formylphenyl benzoic acid

Conditions
ConditionsYield
With dihydrogen peroxide at 20 - 70℃; for 15h; Green chemistry;A 90%
B 8%
...Expand
isophthalic acid
121-91-5

isophthalic acid

carbonic acid dimethyl ester
616-38-6

carbonic acid dimethyl ester

dimethyl Isophthalate
1459-93-4

dimethyl Isophthalate

Conditions
ConditionsYield
With layered double hydroxide - supported L-methionine at 180℃; for 6h; Autoclave; chemoselective reaction;89%
With dimanganese decacarbonyl at 180℃; for 1h; Sealed tube;
tert-butyl methyl ether
1634-04-4

tert-butyl methyl ether

benzene 1,3-dicarboxylic acid monomethyl ester
1877-71-0

benzene 1,3-dicarboxylic acid monomethyl ester

dimethyl Isophthalate
1459-93-4

dimethyl Isophthalate

Conditions
ConditionsYield
With iron(III) trifluoromethanesulfonate at 90℃; Schlenk technique;88%
propynoic acid methyl ester
922-67-8

propynoic acid methyl ester

methyl 5-(N,N-dimethylamino)-2,4-pentadienoate
187808-48-6

methyl 5-(N,N-dimethylamino)-2,4-pentadienoate

dimethyl Isophthalate
1459-93-4

dimethyl Isophthalate

Conditions
ConditionsYield
In xylene for 12h; Heating;87.3%
methanol
67-56-1

methanol

1-bromo-3-chlorobenzene
108-37-2

1-bromo-3-chlorobenzene

carbon monoxide
201230-82-2

carbon monoxide

A

dimethyl Isophthalate
1459-93-4

dimethyl Isophthalate

B

methyl 3-chlorobenzoate
2905-65-9

methyl 3-chlorobenzoate

C

3-chlorobenzoate
535-80-8

3-chlorobenzoate

Conditions
ConditionsYield
With tert-Amyl alcohol; sodium hydride; cobalt(II) acetate In tetrahydrofuran at 40℃; under 760 Torr; for 8h; Irradiation;A 2.5%
B 86%
C 9.5%
...Expand
methanol
67-56-1

methanol

carbon monoxide
201230-82-2

carbon monoxide

1,3-dibromobenzene
108-36-1

1,3-dibromobenzene

A

isophthalic acid
121-91-5

isophthalic acid

B

dimethyl Isophthalate
1459-93-4

dimethyl Isophthalate

C

methyl 3-bromobenzoate
618-89-3

methyl 3-bromobenzoate

Conditions
ConditionsYield
With tert-Amyl alcohol; sodium hydride; cobalt(II) acetate In tetrahydrofuran at 40℃; under 760 Torr; for 14h; Irradiation;A 5%
B 86%
C 8%
...Expand
1-bromo-3-chlorobenzene
108-37-2

1-bromo-3-chlorobenzene

carbon monoxide
201230-82-2

carbon monoxide

A

dimethyl Isophthalate
1459-93-4

dimethyl Isophthalate

B

methyl 3-chlorobenzoate
2905-65-9

methyl 3-chlorobenzoate

C

3-chlorobenzoate
535-80-8

3-chlorobenzoate

Conditions
ConditionsYield
With methanol; tert-Amyl alcohol; sodium hydride; cobalt(II) acetate In tetrahydrofuran at 40℃; under 760 Torr; for 8h; Irradiation;A 2.5%
B 86%
C 9.5%
...Expand
carbon monoxide
201230-82-2

carbon monoxide

1,3-dibromobenzene
108-36-1

1,3-dibromobenzene

A

isophthalic acid
121-91-5

isophthalic acid

B

dimethyl Isophthalate
1459-93-4

dimethyl Isophthalate

C

methyl 3-bromobenzoate
618-89-3

methyl 3-bromobenzoate

Conditions
ConditionsYield
With methanol; tert-Amyl alcohol; sodium hydride; cobalt(II) acetate In tetrahydrofuran at 40℃; under 760 Torr; for 14h; Irradiation;A 5%
B 86%
C 8%
...Expand
methanol
67-56-1

methanol

(1S,4S,8R)-8-(2-Chloro-ethoxy)-3-oxo-2-oxa-bicyclo[2.2.2]oct-5-ene-6-carboxylic acid methyl ester
126717-94-0, 126786-51-4

(1S,4S,8R)-8-(2-Chloro-ethoxy)-3-oxo-2-oxa-bicyclo[2.2.2]oct-5-ene-6-carboxylic acid methyl ester

dimethyl Isophthalate
1459-93-4

dimethyl Isophthalate

Conditions
ConditionsYield
With toluene-4-sulfonic acid for 6h; Heating;83%
methyl coumalate
6018-41-3

methyl coumalate

methyl (2E)-3-methoxy-2-propenoate
5788-17-0

methyl (2E)-3-methoxy-2-propenoate

dimethyl Isophthalate
1459-93-4

dimethyl Isophthalate

Conditions
ConditionsYield
In toluene at 200℃; for 16h; Diels-Alder Cycloaddition; Inert atmosphere; Sealed tube;83%
methyl 8-butoxy-3-oxo-2-oxabicyclo[2.2.2]oct-5-ene-6-carboxylate

methyl 8-butoxy-3-oxo-2-oxabicyclo[2.2.2]oct-5-ene-6-carboxylate

dimethyl Isophthalate
1459-93-4

dimethyl Isophthalate

Conditions
ConditionsYield
With toluene-4-sulfonic acid In methanol at 65℃; for 18h; Catalytic behavior; Reagent/catalyst; Temperature;82%
methanol
67-56-1

methanol

benzene 1,3-dicarboxylic acid monomethyl ester
1877-71-0

benzene 1,3-dicarboxylic acid monomethyl ester

dimethyl Isophthalate
1459-93-4

dimethyl Isophthalate

Conditions
ConditionsYield
With oxygen; potassium carbonate In hexane at 20℃; for 14h; Sonication;72%
methanol
67-56-1

methanol

isophthalic acid
121-91-5

isophthalic acid

A

dimethyl Isophthalate
1459-93-4

dimethyl Isophthalate

B

dimethyl 5-bromoisophthalate
51760-21-5

dimethyl 5-bromoisophthalate

Conditions
ConditionsYield
Stage #1: isophthalic acid With sulfuric acid; sulfur trioxide; bromine at 150℃; for 7h;
Stage #2: methanol With sulfuric acid at 120℃;		A 26.8%
B 65.1%
...Expand
4-amino-1-hydroxycyclohexa-3,5-diene-1,3-dicarboxylic acid dimethyl ester
177913-48-3

4-amino-1-hydroxycyclohexa-3,5-diene-1,3-dicarboxylic acid dimethyl ester

dimethyl Isophthalate
1459-93-4

dimethyl Isophthalate

Conditions
ConditionsYield
With BF3 etherate; sodium hydrogencarbonate In dichloromethane; benzene62%
methanol
67-56-1

methanol

m-xylene
108-38-3

m-xylene

A

dimethyl Isophthalate
1459-93-4

dimethyl Isophthalate

B

1-methoxycarbonyl-3-methylbenzene
99-36-5

1-methoxycarbonyl-3-methylbenzene

C

m-Toluic acid
99-04-7

m-Toluic acid

Conditions
ConditionsYield
Stage #1: m-xylene With manganese(IV) oxide; oxygen; cobalt(II) diacetate tetrahydrate at 156℃; under 7500.75 Torr;
Stage #2: methanol Reagent/catalyst; Temperature; Pressure;		A 8.3%
B 57.7%
C 24.9%
...Expand
methanol
67-56-1

methanol

(1S,4S,8R)-8-Ethoxy-3-oxo-2-oxa-bicyclo[2.2.2]oct-5-ene-6-carboxylic acid methyl ester
95536-87-1, 126786-50-3

(1S,4S,8R)-8-Ethoxy-3-oxo-2-oxa-bicyclo[2.2.2]oct-5-ene-6-carboxylic acid methyl ester

dimethyl Isophthalate
1459-93-4

dimethyl Isophthalate

Conditions
ConditionsYield
With toluene-4-sulfonic acid for 6h; Heating;51%
methanol
67-56-1

methanol

isophthalic acid
121-91-5

isophthalic acid

A

dimethyl Isophthalate
1459-93-4

dimethyl Isophthalate

B

benzene 1,3-dicarboxylic acid monomethyl ester
1877-71-0

benzene 1,3-dicarboxylic acid monomethyl ester

Conditions
ConditionsYield
With sulfuric acid In tetrahydrofuran at 65℃;A n/a
B 42%
...Expand
4-methoxycarbonyl-3a,4-dihydrophthalide
96600-64-5

4-methoxycarbonyl-3a,4-dihydrophthalide

propynoic acid methyl ester
922-67-8

propynoic acid methyl ester

A

4-methoxycarbonyl-phthalide
65399-15-7

4-methoxycarbonyl-phthalide

B

phthalic acid dimethyl ester
131-11-3

phthalic acid dimethyl ester

C

dimethyl Isophthalate
1459-93-4

dimethyl Isophthalate

Conditions
ConditionsYield
In xylene for 40h; Heating;A 37%
B 10%
C 41%
...Expand
diazomethane
186581-53-3, 908094-01-9

diazomethane

isophthalic acid
121-91-5

isophthalic acid

dimethyl Isophthalate
1459-93-4

dimethyl Isophthalate

Conditions
ConditionsYield
With diethyl ether
methanol
67-56-1

methanol

benzene-1,3-dicarbonyl dichloride
99-63-8

benzene-1,3-dicarbonyl dichloride

dimethyl Isophthalate
1459-93-4

dimethyl Isophthalate

isophthalic acid ; disilver (I)-compound
57664-97-8, 64803-72-1

isophthalic acid ; disilver (I)-compound

methyl iodide
74-88-4

methyl iodide

dimethyl Isophthalate
1459-93-4

dimethyl Isophthalate

dimethyl Isophthalate
1459-93-4

dimethyl Isophthalate

isophthalic dihydrazide
2760-98-7

isophthalic dihydrazide

Conditions
ConditionsYield
With hydrazine hydrate In methanol at 70℃; for 4h;100%
With hydrazine hydrate In methanol91%
With hydrazine hydrate In ethanol Reflux;86%
dimethyl Isophthalate
1459-93-4

dimethyl Isophthalate

dimethyl amine
124-40-3

dimethyl amine

N,N-dimethylisophthalamic acid methyl ester
69383-71-7

N,N-dimethylisophthalamic acid methyl ester

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In tetrahydrofuran; methanol at 20℃; for 2h;100%
dimethyl Isophthalate
1459-93-4

dimethyl Isophthalate

benzene 1,3-dicarboxylic acid monomethyl ester
1877-71-0

benzene 1,3-dicarboxylic acid monomethyl ester

Conditions
ConditionsYield
With potassium hydroxide In methanol at 20℃; for 15h;99.2%
With sodium hydroxide In methanol; acetone at 20℃; for 24h; Substitution;98%
Stage #1: dimethyl Isophthalate With methanol; sodium hydroxide In acetone at 20℃; for 25h; Inert atmosphere;
Stage #2: With hydrogenchloride; water pH=1;		98%
dimethyl Isophthalate
1459-93-4

dimethyl Isophthalate

1,3-dimethanol benzene
626-18-6

1,3-dimethanol benzene

Conditions
ConditionsYield
With C24H38Cl2N3PRu; hydrogen; sodium methylate In tetrahydrofuran at 25℃; under 38002.6 Torr; for 16h; Autoclave;99%
With C24H38Cl2N3PRu; hydrogen; sodium methylate In tetrahydrofuran at 25℃; under 37503.8 Torr; for 16h;99%
With lithium borohydride In tetrahydrofuran at 20℃; for 23h;95%
dimethyl Isophthalate
1459-93-4

dimethyl Isophthalate

bis(pinacol)diborane
73183-34-3

bis(pinacol)diborane

dimethyl 5-(pinacolboryl)isophthalate
944392-68-1

dimethyl 5-(pinacolboryl)isophthalate

Conditions
ConditionsYield
With bis(1,5-cyclooctadiene)diiridium(I) dichloride; 1-(4,4'-di-tert-butyl-[2,2'-bipyridin]-6-yl)-2-(dimethyl(phenyl)silyl)-2,3-dihydro-1H-benzo[d][1,3,2]diazaborole Inert atmosphere; Schlenk technique; Sealed tube;99%
With (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; cyclopentyl methyl ether; 1,1'-di(pyridin-2-yl)-1,1',3,3'-tetrahydro-2,2'-bibenzo[d][1,3,2]diazaborole at 100℃; for 16h; Schlenk technique; Inert atmosphere;95%
Stage #1: bis(pinacol)diborane With C24H28ClIrN2O In n-heptane; isopropyl alcohol at 75℃; for 1h; Sealed tube; Inert atmosphere;
Stage #2: dimethyl Isophthalate In n-heptane; isopropyl alcohol Sealed tube; Inert atmosphere;		91%
4-AMINO-2,2,6,6-TETRAMETHYLPIPERIDINE
36768-62-4

4-AMINO-2,2,6,6-TETRAMETHYLPIPERIDINE

dimethyl Isophthalate
1459-93-4

dimethyl Isophthalate

N,N'-bis(2,2,6,6-tetramethyl-4-piperidinyl)-1,3-benzenedicarboxamide
42774-15-2

N,N'-bis(2,2,6,6-tetramethyl-4-piperidinyl)-1,3-benzenedicarboxamide

Conditions
ConditionsYield
With sodium methylate In methanol at 60 - 110℃; for 1.5h; Temperature; Inert atmosphere; Large scale;98.5%
In octane at 150 - 160℃; under 6750.68 - 8250.83 Torr; for 15h; Pressure; Solvent; Temperature; Autoclave; Inert atmosphere;97%
With solid supported catalyst C1 In acetonitrile at 20 - 70℃; for 15h; Reagent/catalyst;96.7%
at 190 - 230℃; for 7h; Large scale;93.5%
at 190 - 230℃; for 7h; Large scale;93.5%
2-propynyl 2,3:4,6-di-O-isopropylidene-α-D-mannopyranoside
854261-90-8

2-propynyl 2,3:4,6-di-O-isopropylidene-α-D-mannopyranoside

dimethyl Isophthalate
1459-93-4

dimethyl Isophthalate

1,3-bis-[1,7-di-O-(2,3:4,6-di-O-isopropylidene-α-D-mannopyranosyl)hep-2,5-diyn-1,4,7-triol-4-yl]benzene
854261-97-5

1,3-bis-[1,7-di-O-(2,3:4,6-di-O-isopropylidene-α-D-mannopyranosyl)hep-2,5-diyn-1,4,7-triol-4-yl]benzene

Conditions
ConditionsYield
Stage #1: 2-propynyl 2,3:4,6-di-O-isopropylidene-α-D-mannopyranoside With n-butyllithium In tetrahydrofuran; hexane at 0℃; for 1h;
Stage #2: dimethyl Isophthalate In tetrahydrofuran; hexane at 20℃; for 24h;		98%
dimethyl Isophthalate
1459-93-4

dimethyl Isophthalate

ethylenediamine
107-15-3

ethylenediamine

B
40221-64-5

B

Conditions
ConditionsYield
In methanol at 25℃; for 12h;98%
In acetonitrile for 5h; Reflux;31.3%
dimethyl Isophthalate
1459-93-4

dimethyl Isophthalate

Trimethylenediamine
109-76-2

Trimethylenediamine

1,3-bis-[N-((N'-3-aminopropyl)propyl-3-amine)methylamine]benzene
819883-45-9

1,3-bis-[N-((N'-3-aminopropyl)propyl-3-amine)methylamine]benzene

Conditions
ConditionsYield
In methanol at 25℃; for 12h;98%
dimethyl Isophthalate
1459-93-4

dimethyl Isophthalate

1,4-diaminobutane
110-60-1

1,4-diaminobutane

C16H26N4O2
1104610-46-9

C16H26N4O2

Conditions
ConditionsYield
In methanol at 25℃; for 12h;98%
dimethyl Isophthalate
1459-93-4

dimethyl Isophthalate

dibutyldimethoxytin
1067-55-6

dibutyldimethoxytin

2,2-dimethoxyethylamine
22483-09-6

2,2-dimethoxyethylamine

N,N'-bis(2,2-dimethoxyethyl)isophthalamide

N,N'-bis(2,2-dimethoxyethyl)isophthalamide

Conditions
ConditionsYield
94%
...Expand
dimethyl Isophthalate
1459-93-4

dimethyl Isophthalate

dimethyl 5-nitroisophthalate
13290-96-5

dimethyl 5-nitroisophthalate

Conditions
ConditionsYield
With iron(III) chloride; Nitrogen dioxide; ozone In 1,2-dichloro-ethane at 5℃; for 1.5h; Product distribution; Further Variations:; Solvents; Reagents;92%
With sulfur dioxide; dinitrogen pentoxide 1.) -78 to -11 deg C, 2 h, 2.) -11 deg C, 2 h;90%
With sulfuric acid; sulfur trioxide; nitric acid
dimethyl Isophthalate
1459-93-4

dimethyl Isophthalate

dimethyl cyclohexane-1,3-dicarboxylate
62638-06-6

dimethyl cyclohexane-1,3-dicarboxylate

Conditions
ConditionsYield
With hydrogen; W-2 Raney nickel In tetrahydrofuran at 130℃; under 87915.2 Torr; for 30h;91%
With hydrogen; Rh/Al2O3 under 2585.7 Torr;85%
With hydrogen; tetra(n-butyl)ammonium hydrogensulfate; di-μ-chlorobis(norbornadiene)dirhodium(I) In phosphate buffer; cyclohexane at 60℃; under 2585.74 Torr; for 24h; pH=7.4; Catalytic hydrogenation;82.1%
With hydrogen; W 2 Raney nickel In tetrahydrofuran; methanol at 100 - 105℃; under 82743.7 Torr; for 15h;80%
With hydrogen; Rh/Al2O3
dimethyl Isophthalate
1459-93-4

dimethyl Isophthalate

5-iodo-isophthalic acid dimethyl ester
51839-15-7

5-iodo-isophthalic acid dimethyl ester

Conditions
ConditionsYield
With sodium periodate; sulfuric acid; iodine at 36℃; for 12h; Inert atmosphere;91%
With sodium periodate; sulfuric acid; iodine at 20℃;76%
With sodium periodate; sulfuric acid; iodine at 30℃;61%
dimethyl Isophthalate
1459-93-4

dimethyl Isophthalate

propan-1-ol-3-amine
156-87-6

propan-1-ol-3-amine

N,N’-bis(3-hydroxypropyl)isophthalamide
42089-95-2

N,N’-bis(3-hydroxypropyl)isophthalamide

Conditions
ConditionsYield
at 120 - 140℃; for 2.5h;90%
dimethyl Isophthalate
1459-93-4

dimethyl Isophthalate

3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

C17H13NO3

C17H13NO3

Conditions
ConditionsYield
With n-butyllithium In tetrahydrofuran; hexane at -78℃; Inert atmosphere;90%
dimethyl Isophthalate
1459-93-4

dimethyl Isophthalate

hexadecylmagnesium halogenide

hexadecylmagnesium halogenide

17,17'-(1,3-phenylene)ditritriacontan-17-ol
1350559-68-0

17,17'-(1,3-phenylene)ditritriacontan-17-ol

Conditions
ConditionsYield
In diethyl ether at 20℃; for 12h;89%

Dimethyl isophthalate Chemical Properties

Molecular Structure of Isophthalic acid dimethyl ester (CAS NO.1459-93-4):

Molecular Formula: C10H10O4
Molecular Weight: 194.184
IUPAC Name: Dimethyl benzene-1,3-dicarboxylate
Synonyms of Isophthalic acid dimethyl ester (CAS NO.1459-93-4): 1,3-Benzenedicarboxylic acid, dimethyl ester ; 4-09-00-03293 (Beilstein Handbook Reference) ; AI3-02247 ; BRN 1912251 ; Dimethyl 1,3-benzenedicarboxylate ; Dimethyl isophthalate ; Dimethyl m-phthalate ; Dimethylester kyseliny isoftalove ; Dimethylester kyseliny isoftalove [Czech] ; EINECS 215-951-9 ; HSDB 6138 ; Isophthalic acid dimethyl ester ; Methyl 3-(carbomethoxy)benzoate ; Methyl isophthalate ; Morflex 1129 ; NSC 15313 ; 1,3-Benzenedicarboxylic acid, 1,3-dimethyl ester
CAS NO: 1459-93-4
Classification Code: Skin / Eye Irritant
Melting point: 64-68 °C
Polar Surface Area: 52.6 Å2
Index of Refraction: 1.514
Molar Refractivity: 49.79 cm3
Molar Volume: 165.2 cm3
Surface Tension: 40.5 dyne/cm
Density of Isophthalic acid dimethyl ester (CAS NO.1459-93-4): 1.175 g/cm3
Flash Point: 148 °C
Enthalpy of Vaporization: 52.4 kJ/mol
Boiling Point: 285 °C at 760 mmHg
Vapour Pressure: 0.00288 mmHg at 25°C

Dimethyl isophthalate Uses

 Isophthalic acid dimethyl ester (CAS NO.1459-93-4) is synthesis of phthalates, as diphenyl-resistant polymer monomers PBT, other organic synthesis, for stationary liquid.

Dimethyl isophthalate Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LDLo intraperitoneal 971mg/kg (971mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)		 Journal of Pharmaceutical Sciences. Vol. 56, Pg. 1446, 1967.

Dimethyl isophthalate Consensus Reports

Reported in EPA TSCA Inventory.

Dimethyl isophthalate Safety Profile

Hazard Codes of Isophthalic acid dimethyl ester (CAS NO.1459-93-4): IrritantXi
Risk Statements: 36 
R36: Irritating to eyes.
Safety Statements: 26-36 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36: Wear suitable protective clothing.
WGK Germany: 3
RTECS: NT2540000
HS Code: 29173980
Hazardous Substances Data: 1459-93-4(Hazardous Substances Data)
Moderately toxic by intraperitoneal route. An eye irritant. When heated to decomposition it emits acrid smoke and fumes. See also ESTERS.

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