Ethyl formate supplier | CasNO.109-94-4

Name
Ethyl formate
EINECS 203-721-0
CAS No. 109-94-4
Article Data254
CAS DataBase
Density 0.906 g/cm³
Solubility soluble in water
Melting Point -80 °C(lit.)
Formula C₃H₆O₂
Boiling Point 54.7 °C at 760 mmHg
Molecular Weight 74.0794
Flash Point 7°F
Transport Information UN 1190 3/PG 2
Appearance colourless liquid with an aromatic odour
Safety 9-16-24-26-33
Risk Codes 11-20/22-36/37
Molecular Structure
Hazard Symbols F,Xn
Synonyms Areginal;Ethyl methanoate;Methanoic acid ethyl ester;NSC 406578;NSC8828;Ethyl ester of formic acid;Ethylformiat;Formic acid, ethylester;
PSA 26.30000
LogP 0.81520

Synthetic route

: 64-18-6
formic acid

: 454-31-9
ethyl difluoroacetate

A: 381-73-7
Difluoroacetic acid

B: 109-94-4
formic acid ethyl ester

Conditions

Conditions	Yield
sulfuric acid at 70℃; Product distribution / selectivity;	A 96% B n/a

...Expand

: 539-88-8
4-oxopentanoic acid ethyl ester

: 122-51-0
orthoformic acid triethyl ester

A: 92557-39-6
ethyl 4,4-diethoxypentanoate

B: 109-94-4
formic acid ethyl ester

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In ethanol at 145℃; ketalization;	A 94% B n/a

...Expand

: 64-17-5
ethanol

: 150760-95-5
formic acid cyanomethyl ester

: 109-94-4
formic acid ethyl ester

Conditions

Conditions	Yield
With 1H-imidazole for 24h; Ambient temperature;	93%
With 1H-imidazole Yield given;

: 122-51-0
orthoformic acid triethyl ester

A: 74-96-4
ethyl bromide

B: 1825-62-3
ethyl trimethylsilyl ether

C: 109-94-4
formic acid ethyl ester

Conditions

Conditions	Yield
With chloro-trimethyl-silane; sodium bromide for 2h; Product distribution; Heating; Me3SiBr generated in situ;	A n/a B n/a C 92%

...Expand

: 64-17-5
ethanol

: 39689-37-7
sodium salt of β-mercaptonaphthalene

A: 32551-87-4
ethyl 2-naphthyl sulfide

B: 109-94-4
formic acid ethyl ester

Conditions

Conditions	Yield
With carbon monoxide at 150℃; under 75006 Torr; for 21h;	A 90% B n/a

...Expand

: 109-92-2
ethyl vinyl ether

A: 50-00-0
formaldehyd

B: 109-94-4
formic acid ethyl ester

Conditions

Conditions	Yield
With ozone at 24.85℃; under 100 Torr; for 0.416667h; Kinetics;	A n/a B 86%
With dihydrogen peroxide at 98.85℃; under 100 Torr; for 4h; Kinetics; Further Variations:; Temperatures; Pressures; Reagents; Irradiation;	A n/a B 83%
With ozone at 24.84℃; under 760.051 Torr; Kinetics; Concentration; Time; Gas phase;	A 15 %Chromat. B 80 %Chromat.

: 79-22-1
methyl chloroformate

: 82833-74-7
dibutyl (diethoxymethyl)phosphine

A: 75-00-3
chloroethane

B: 112499-32-8
dibutyl(methoxycarbonyl)phosphine

C: 109-94-4
formic acid ethyl ester

Conditions

Conditions	Yield
In diethyl ether for 4h; Heating;	A n/a B 85% C n/a

...Expand

: 85233-91-6
tris(2-diphenylphosphanylethyl)aminerhodium(I) hydride

: 623-49-4
ethyl cyanoformate

: 118681-53-1
N(CH2CH2P(C6H5)2)3RhCN

B: 109-94-4
formic acid ethyl ester

Conditions

Conditions	Yield
In tetrahydrofuran soln. of formate added to stirred suspn. of complex (N2), gently warmed to 40°C (1 h), cooled to room temp.; mixt. of ethanol/n-hexane (1:1) added, concd. (brisk current of N2), sepd., collected on sintered glass frits, washed (EtOH, pentane), dried (N2);	A 71% B 85%

...Expand

: 78-39-7
Triethyl orthoacetate

: 107-18-6
allyl alcohol

A: 64-17-5
ethanol

B: 1968-40-7
ethyl 4-pentenoate

C: C9H18O3

D: 141-78-6
ethyl acetate

E: 109-94-4
formic acid ethyl ester

Conditions

Conditions	Yield
With formic acid at 150℃; for 16h; Reagent/catalyst; Johnson-Claisen Rearrangement; Autoclave;	A n/a B 83% C n/a D n/a E n/a

...Expand

: 64-18-6
formic acid

: 866-23-9
diethyl (trichloromethyl)phosphonate

: 109-94-4
formic acid ethyl ester

Conditions

Conditions	Yield
at 120℃; for 24h;	82%

: 67-47-0
5-hydroxymethyl-2-furfuraldehyde

: 64-17-5
ethanol

A: 1917-65-3
5-(ethoxymethyl)furfural

B: 539-88-8
4-oxopentanoic acid ethyl ester

C: 109-94-4
formic acid ethyl ester

Conditions

Conditions	Yield
With sulfuric acid at 75℃; for 24h; Reagent/catalyst; Temperature; Sealed tube;	A 81% B 16% C n/a

...Expand

: 4885-02-3
Dichloromethyl methyl ether

: 65600-72-8
ethyl P-(diethoxymethyl)phosphonite

A: 589-57-1
diethyl phosphorylchloridite

B: 75-00-3
chloroethane

C: 107-31-3
Methyl formate

D: 109-94-4
formic acid ethyl ester

Conditions

Conditions	Yield
at 60 - 70℃; Product distribution; argon atmosphere;	A 80% B n/a C n/a D n/a

...Expand

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: 6065-82-3
Ethyl diethoxyacetate

A: 34640-92-1
2,2-diethoxy-N,N-dimethylacetamide

B: 109-94-4
formic acid ethyl ester

Conditions

Conditions	Yield
With lithium methanolate In methanol at 80℃; for 10h; Product distribution / selectivity;	A 80% B n/a

...Expand

: 109786-30-3
tris(2-diphenylphosphanylethyl)phosphanerhodium(I) hydride

: 623-49-4
ethyl cyanoformate

: 118681-54-2
RhCN(tris(2-(diphenylphosphino)ethyl)phosphine)

B: 109-94-4
formic acid ethyl ester

Conditions

Conditions	Yield
In tetrahydrofuran neat formate pipetted into soln. of complex, heated at ca. 40°C (20-30 min), cooled to room temp.; ethanol/n-hexane 1:1 added, concd. (N2), crystals collected on sintered glass frits, washed (EtOH, pentane), dried (N2);	A 70% B 80%

...Expand

: 80592-18-3
3,4-methylenedioxyphenyl formate

A: 533-31-3
Sesamol

B: 109-94-4
formic acid ethyl ester

Conditions

Conditions	Yield
With ethanol; sodium hydroxide at 82 - 96℃; for 4.5h; Reflux; elimination of ethyl formate;	A 79% B n/a

: 4885-02-3
Dichloromethyl methyl ether

: 95987-39-6
(diethoxymethyl)diisopropylphosphine oxide

A: 75-00-3
chloroethane

B: 107-31-3
Methyl formate

C: 40244-90-4
Chlorodiisopropylphosphane

D: 109-94-4
formic acid ethyl ester

Conditions

Conditions	Yield
at 60℃; for 1h; Product distribution; argon atmosphere;	A n/a B n/a C 76% D n/a

...Expand

: 16972-33-1
pentacarbonylhydridomanganese

: Et-oxycarbonylcobalt tetracarbonyl

A: 35646-82-3
(CO)5MnCo(CO)4

B: 109-94-4
formic acid ethyl ester

Conditions

Conditions	Yield
With carbon monoxide In n-heptane Kinetics; heptane, 25°C, CO atmosphere, 24 h; evapd. in vac. at 0°C, crystd. at -79°C;	A 71% B n/a

...Expand

: 64-18-6
formic acid

: 64-17-5
ethanol

: 109-94-4
formic acid ethyl ester

Conditions

Conditions	Yield
With phosphorus pentoxide; copper(II) sulfate; sodium sulfate for 20h; Ambient temperature;	70%
With Ag2(4,4'-bipy)2(O3SCH2CH2SO3)*4H2O-based polymer Reflux;	70%
With sulfuric acid; mercury(II) sulfate unter Durchleiten von Acetylen;

: 1561-49-5
dicyclohexyl peroxydicarbonate

: 122-51-0
orthoformic acid triethyl ester

A: 25604-46-0
diethoxycyclohexyloxymethane

B: 109-94-4
formic acid ethyl ester

C: 105-58-8
Diethyl carbonate

Conditions

Conditions	Yield
at 60℃; for 2h;	A 70% B n/a C n/a

...Expand

: 122-51-0
orthoformic acid triethyl ester

A: 25604-46-0
diethoxycyclohexyloxymethane

B: 109-94-4
formic acid ethyl ester

C: 105-58-8
Diethyl carbonate

Conditions

Conditions	Yield
With dicyclohexyl peroxydicarbonate at 60℃; for 2h;	A 70% B n/a C n/a
With dicyclohexyl peroxydicarbonate at 60℃; for 4h;	A 0.56 mmol B 0.37 mmol C 0.17 mmol

...Expand

: 292638-84-7
styrene

: 64-17-5
ethanol

A: 50-00-0
formaldehyd

B: 93-89-0
benzoic acid ethyl ester

C: 100-52-7
benzaldehyde

D: 109-94-4
formic acid ethyl ester

Conditions

Conditions	Yield
Stage #1: styrene; ethanol With ozone Stage #2: at 90 - 100℃; Further byproducts given;	A 6% B 63.4% C 6.3% D 20.4%

...Expand

: 67-47-0
5-hydroxymethyl-2-furfuraldehyde

: 64-17-5
ethanol

A: 539-88-8
4-oxopentanoic acid ethyl ester

B: 109-94-4
formic acid ethyl ester

Conditions

Conditions	Yield
With sulfuric acid at 120℃; for 30h; Reagent/catalyst; Sealed tube;	A 62% B n/a

...Expand

: 506-96-7
Acetyl bromide

: 65600-72-8
ethyl P-(diethoxymethyl)phosphonite

A: 74-96-4
ethyl bromide

B: 109-94-4
formic acid ethyl ester

C: 919-19-7
diethyl acetylphosphonate

Conditions

Conditions	Yield
for 1h; Heating; argon atmosphere;	A n/a B n/a C 61%

...Expand

: 116779-75-0
bromoethyl ethyl ether

: 122-51-0
orthoformic acid triethyl ester

A: 105-57-7
diethyl acetal

B: 109-94-4
formic acid ethyl ester

Conditions

Conditions	Yield
at 25℃;	A 61% B n/a

...Expand

: 617-35-6
2-oxo-propionic acid ethyl ester

: 122-51-0
orthoformic acid triethyl ester

A: 7476-20-2
ethyl 2,2-diethoxypropionate

B: 109-94-4
formic acid ethyl ester

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In ethanol	A 61% B n/a

...Expand

: 7081-78-9
1-chloroethyl ethyl ether

: 122-51-0
orthoformic acid triethyl ester

A: 105-57-7
diethyl acetal

B: 109-94-4
formic acid ethyl ester

Conditions

Conditions	Yield
for 12h;	A 59% B n/a

...Expand

: 64-17-5
ethanol

: 50-99-7
D-glucose

A: 64-18-6
formic acid

B: 109-94-4
formic acid ethyl ester

Conditions

Conditions	Yield
With H8[PMo7V5O40]; oxygen In water at 90℃; under 15001.5 Torr; for 24h; Autoclave;	A 56% B 40%

...Expand

: 64-17-5
ethanol

: 67-66-3
chloroform

: 109-94-4
formic acid ethyl ester

Conditions

Conditions	Yield
at 20℃; for 6h; UV-irradiation;	55%

: 64-18-6
formic acid

: 623-81-4
diethyl sulphite

: 109-94-4
formic acid ethyl ester

Conditions

Conditions	Yield
sulfuric acid Heating;	53%

: 61-54-1
tryptamine

: 109-94-4
formic acid ethyl ester

: 6502-82-5
Nb-formyltryptamine

Conditions

Conditions	Yield
for 24h; Reflux;	100%
for 6h; Reflux;	100%
With triethylamine In methanol at 100℃; for 16h; Inert atmosphere;	97%

: 78-81-9
isobutylamine

: 109-94-4
formic acid ethyl ester

: 6281-96-5
N-isobutylformamide

Conditions

Conditions	Yield
for 12h; Reflux; Inert atmosphere;	100%

: 140-29-4
phenylacetonitrile

: 109-94-4
formic acid ethyl ester

: 5841-70-3
phenyl(formyl)acetonitrile

Conditions

Conditions	Yield
With sodium hydride	100%
With sodium hydride In tetrahydrofuran at 50℃; for 0.333333h;	86%
With sodium In ethanol at 0 - 40℃;	78.7%

: 141-43-5
ethanolamine

: 109-94-4
formic acid ethyl ester

: 693-06-1
(2-hydroxyethyl)-formamide

Conditions

Conditions	Yield
Stage #1: ethanolamine With sodium ethanolate at 20℃; for 0.5h; Stage #2: formic acid ethyl ester In ethanol for 1h; Heating; Further stages.;	100%
at 10 - 20℃; for 12h;	100%
	99%

: 105-39-5
chloroacetic acid ethyl ester

: 109-94-4
formic acid ethyl ester

: 33142-21-1
ethyl 2-chloro-3-oxopropanoate

Conditions

Conditions	Yield
With sodium ethanolate In tert-butyl methyl ether at 0 - 20℃; Inert atmosphere; Large scale;	100%
With sodium ethanolate In tert-butyl methyl ether at 0 - 20℃; Inert atmosphere; Large scale;	100%
With potassium tert-butylate In tetrahydrofuran at 0 - 20℃; for 16h; Inert atmosphere;	95%

: 618-36-0
rac-methylbenzylamine

: 109-94-4
formic acid ethyl ester

: 6948-01-2
N-formyl-α-methylbenzylamine

Conditions

Conditions	Yield
for 8h; Reflux;	100%
With Novozyme 435 CALB In tetrahydrofuran at 20℃; Green chemistry; Enzymatic reaction;	94%
With 1-(3-sulfopropyl)pyridinium phosphotungstate In neat (no solvent) at 70℃; for 15h; Microwave irradiation; Sealed tube; Inert atmosphere;	81%

: 156-87-6
propan-1-ol-3-amine

: 109-94-4
formic acid ethyl ester

: 49807-74-1
3-(N-formylamino)propan-1-ol

Conditions

Conditions	Yield
	100%
Reflux;	100%
at 50℃; for 2.25h; Cooling with ice;	95%

: 124-22-1
n-Dodecylamine

: 109-94-4
formic acid ethyl ester

: 7402-57-5
N-(dodecyl)formamide

Conditions

Conditions	Yield
for 20h; Inert atmosphere; Reflux;	100%

: 109-94-4
formic acid ethyl ester

: 123-25-1
succinic acid diethyl ester

: 5472-38-8
diethyl 2-formylbutanedioate

Conditions

Conditions	Yield
With sodium In diethyl ether at 40℃; for 5h;	100%
With sodium In diethyl ether at 40℃; for 5h;	100%
With sodium hydride In toluene at 20℃; for 16h; Reagent/catalyst;	95.1%

: 107-11-9
1-amino-2-propene

: 109-94-4
formic acid ethyl ester

: 16250-37-6
N-allylformamide

Conditions

Conditions	Yield
at 60℃; for 6h;	100%
for 1h; Heating;	86%
at 0 - 20℃; Inert atmosphere;	80%

: 5162-44-7
1-bromo-4-butene

: 109-94-4
formic acid ethyl ester

: 94427-72-2
1,8-nonadiene-5-ol

Conditions

Conditions	Yield
Stage #1: 1-bromo-4-butene With magnesium In tetrahydrofuran at 0 - 20℃; Inert atmosphere; Stage #2: formic acid ethyl ester In tetrahydrofuran at 0 - 20℃; Inert atmosphere;	100%
Stage #1: 1-bromo-4-butene With iodine; magnesium In tetrahydrofuran at 20℃; for 0.5h; Inert atmosphere; Stage #2: formic acid ethyl ester In tetrahydrofuran at 0 - 20℃; for 3h; Inert atmosphere;	98%
Stage #1: 1-bromo-4-butene With iodine; magnesium In tetrahydrofuran at 20℃; Inert atmosphere; Stage #2: formic acid ethyl ester In tetrahydrofuran at 0 - 20℃; Inert atmosphere;	94%

: 2516-34-9
cyclobutylamine

: 109-94-4
formic acid ethyl ester

: 87055-64-9
N-cyclobutylformamide

Conditions

Conditions	Yield
for 4h; Heating;	100%
With Novozyme 435 CALB In tetrahydrofuran at 20℃; Green chemistry; Enzymatic reaction;	98%
With toluene-4-sulfonic acid

: 2627-86-3
(S)-1-phenyl-ethylamine

: 109-94-4
formic acid ethyl ester

: 19145-06-3
(S)-N-formyl-1-phenylethylamine

Conditions

Conditions	Yield
In toluene for 15h; Heating;	100%
With Novozyme 435 CALB In tetrahydrofuran at 20℃; Green chemistry; Enzymatic reaction;	95%

: 3886-69-9
(R)-1-phenyl-ethyl-amine

: 109-94-4
formic acid ethyl ester

: 6948-01-2, 19145-06-3, 31502-34-8, 42412-77-1
(R)-(+)-α-methylbenzyl formamide

Conditions

Conditions	Yield
for 8h; Reflux;	100%
With amberlyst 15 In tetrahydrofuran for 21h; Reflux; Inert atmosphere;	99%
With Novozyme 435 CALB In tetrahydrofuran at 20℃; Green chemistry; Enzymatic reaction;	92%

: 96-48-0
4-butanolide

: 109-94-4
formic acid ethyl ester

: 51270-64-5, 54211-97-1, 93698-26-1
sodium salt of (Z)-3-(hydroxymethylene)dihydro-2(3H)-furanone

Conditions

Conditions	Yield
With sodium hydride	100%
With sodium In diethyl ether at -20 - -15℃; for 5h;

: 96-48-0
4-butanolide

: 109-94-4
formic acid ethyl ester

: 54211-97-1
sodium salt of (E)-3-(hydroxymethylene)dihydro-2(3H)-furanone

Conditions

Conditions	Yield
With sodium hydride	100%
With ethanol; sodium hydride In 1,2-dimethoxyethane at 40℃; for 22h; cross-Claisen acylation;	97%
With sodium methylate In diethyl ether for 12h;	69%
With sodium hydroxide In 1,2-dimethoxyethane at 60℃; for 16h;	66%

: 542-28-9
3,4,5,6-tetrahydro-2H-pyran-2-one

: 109-94-4
formic acid ethyl ester

: Sodium; [2-oxo-dihydro-pyran-(3Z)-ylidene]-methanolate

Conditions

Conditions	Yield
With sodium hydride	100%

: 3731-51-9
(2-aminomethylpyridine)

: 109-94-4
formic acid ethyl ester

: 56625-03-7
N-((pyridin-2-yl)methyl)formamide

Conditions

Conditions	Yield
for 1.5h; Reflux;	100%
at 25℃; for 8h;

: 108-94-1
cyclohexanone

: 109-94-4
formic acid ethyl ester

: 823-45-0
2-(hydroxymethylene)cyclohexanone

Conditions

Conditions	Yield
With sodium hydride In tetrahydrofuran; paraffin oil at 10 - 20℃;	100%
With sodium methylate In toluene for 24h;	94%
With ethanol; sodium hydride In diethyl ether; mineral oil at 20℃;	92%

: 120-20-7
2-(3,4-dimethoxyphenyl)-ethylamine

: 109-94-4
formic acid ethyl ester

: 14301-36-1
N-[2-(3,4-dimethoxyphenyl)ethyl]formamide

Conditions

Conditions	Yield
at 70℃; for 20h;	100%
at 70℃;	100%
Reflux;	99%

: 1003-03-8
Cyclopentamine

: 109-94-4
formic acid ethyl ester

: 41215-40-1
N-cyclopentylcarboxamide

Conditions

Conditions	Yield
for 4h; Heating;	100%
for 3h; Heating;	97%
Heating;
Reflux;
In ethanol at 90℃; for 9h;

: 765-30-0
Cyclopropylamine

: 109-94-4
formic acid ethyl ester

: 58644-54-5
N-cyclopropylformamide

Conditions

Conditions	Yield
for 4h; Heating;	100%
at 50℃; for 5h;	84%
With sodium carbonate In ethanol for 20h; Ambient temperature;	59%

: 2039-67-0
2-(3-methoxyphenyl)-1-ethanamine

: 109-94-4
formic acid ethyl ester

: 110339-54-3
N-[2-(3-methoxy-phenyl)-ethyl]-formamide

Conditions

Conditions	Yield
In toluene for 6h; Heating;	100%

: 23356-96-9
(S)-1-Pyrrolidin-2-yl-methanol

: 109-94-4
formic acid ethyl ester

: 55456-46-7
(S)-(-)-1-Formyl-2-(hydroxymethyl)pyrrolidine

Conditions

Conditions	Yield
at 50℃;	100%

: 1450-72-2
5-methyl-2-hydroxyacetophenone

: 109-94-4
formic acid ethyl ester

: 90617-36-0
2,3-dihydro-2-hydroxy-6-methyl-1-benzopyran-4-one

Conditions

Conditions	Yield
With sodium methylate In tetrahydrofuran at 20℃; for 0.5h;	100%
With sodium In diethyl ether Heating;	74%

: 22231-61-4
2-[4-(benzyloxy)-3-methoxyphenyl]ethylamine

: 109-94-4
formic acid ethyl ester

: 55803-41-3
N-formyl-2-[3-methoxy-4-(benzyloxy)phenyl]ethylamine

Conditions

Conditions	Yield
In tetrahydrofuran for 12h; Reflux;	100%
for 12h; Inert atmosphere; Reflux;	95%
for 1h; Heating;	78%
at 70 - 80℃; for 8h;	50.72%

: 2026-48-4
(S)-valinol

: 109-94-4
formic acid ethyl ester

: 89876-66-4
(S)-N-[1-(hydroxymethyl)-2-methylpropyl]formamide

Conditions

Conditions	Yield
for 4h; Heating;	100%
Reflux;	99%
for 2h; Heating;	95%

: 112-53-8
1-dodecyl alcohol

: 109-94-4
formic acid ethyl ester

: 28303-42-6
1-dodecanyl formate

Conditions

Conditions	Yield
cerium (IV) sulfate; silica gel for 1h; Heating;	100%

: 114049-99-9
1-dimethylamino-butan-2-one

: 109-94-4
formic acid ethyl ester

: Sodium; (Z)-4-dimethylamino-2-methyl-3-oxo-but-1-en-1-olate

Conditions

Conditions	Yield
With sodium hydride In toluene	100%

: 459-72-3
ethyl 2-fluoroacetate

: 109-94-4
formic acid ethyl ester

: 1652-39-7
(1-ethoxy-2-fluoro-1,3-dioxopropan-2-yl) sodium

Conditions

Conditions	Yield
With sodium hydride In diethyl ether; ethanol; mineral oil at 20℃; Inert atmosphere; Cooling with ice;	100%
With sodium ethanolate In tetrahydrofuran at 0 - 20℃;	94.7%
With sodium hydride In diethyl ether for 2h; Ambient temperature;
With ethanol; sodium hydride In diethyl ether; mineral oil at 20℃; Inert atmosphere; Cooling with ice;

Ethyl formate Consensus Reports

Reported in EPA TSCA Inventory.

Ethyl formate Standards and Recommendations

OSHA PEL: TWA 100 ppm
ACGIH TLV: TWA 100 ppm
DFG MAK: 100 ppm (310 mg/m³)
DOT Classification: 3; Label: Flammable Liquid

Ethyl formate Analytical Methods

For occupational chemical analysis use NIOSH: Ethyl Formate S36.

Ethyl formate Specification

The Ethyl formate, with the CAS registry number 109-94-4 and EINECS registry number 203-721-0, is a kind of colourless liquid with an aromatic odour. It is moisture sensitive ester, and belongs to the following product categories: Organics; Analytical Chemistry; Solvents for HPLC & Spectrophotometry; Solvents for Spectrophotometry. And the molecular formula of this chemical is C₃H₆O₂.

The physical properties of Ethyl formate are as followings: (1)ACD/LogP: 0.30; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 0.3; (4)ACD/LogD (pH 7.4): 0.3; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 34.63; (8)ACD/KOC (pH 7.4): 34.63; (9)#H bond acceptors: 2; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 2; (12)Polar Surface Area: 26.3 Å²; (13)Index of Refraction: 1.356; (14)Molar Refractivity: 17.87 cm³; (15)Molar Volume: 81.7 cm³; (16)Polarizability: 7.08×10^-24cm³; (17)Surface Tension: 23.5 dyne/cm; (18)Density: 0.906 g/cm³; (19)Enthalpy of Vaporization: 29.91 kJ/mol; (20)Boiling Point: 54.7 °C at 760 mmHg; (21)Vapour Pressure: 242 mmHg at 25°C.

Preparation of Ethyl formate: It can start with esterification of formic acid and ethanol in the presence of catalyst sulphuric acid. And after neutralization and washing, you can get the product.
HCOOH + C₂H₅OH → HCOOC₂H₅ + H₂O

Uses of Ethyl formate: It is an important intermediates in organic synthesis. It is usually used as the solution for nitro acetyl cellulose and marlspum, and bactericide, fumigant & larvicide for food. It is also used as essence.

You should be cautious while dealing with this chemical. It is a kind of flammable chemical which irritates eyes and respiratory system, and it is also harmful by inhalation and if swallowed. Therefore, you had better take the following instructions: Keep container in a well-ventilated place; Keep away from sources of ignition - No smoking; Avoid contact with skin; In case of contact with eyes, rinse immediately with plenty of water and seek medical advice; Take precautionary measures against static discharges.

You can still convert the following datas into molecular structure:
(1)SMILES: O=COCC
(2)InChI: InChI=1/C3H6O2/c1-2-5-3-4/h3H,2H2,1H3
(3)InChIKey: WBJINCZRORDGAQ-UHFFFAOYAO

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
guinea pig	LD50	oral	1110mg/kg (1110mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: GASTRITIS	Food and Cosmetics Toxicology. Vol. 2, Pg. 327, 1964.
rabbit	LD50	oral	2075mg/kg (2075mg/kg)		Industrial Medicine and Surgery. Vol. 41, Pg. 31, 1972.
rabbit	LD50	skin	> 20mL/kg (20mL/kg)		AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 10, Pg. 61, 1954.
rabbit	LDLo	subcutaneous	1gm/kg (1000mg/kg)		Food and Cosmetics Toxicology. Vol. 16, Pg. 737, 1978.
rat	LCLo	inhalation	8000ppm/4H (8000ppm)		AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 10, Pg. 61, 1954.
rat	LD50	oral	1850mg/kg (1850mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Food and Cosmetics Toxicology. Vol. 2, Pg. 327, 1964.

Product Name

Ethyl formate

Synthetic route

Ethyl formate Consensus Reports

Ethyl formate Standards and Recommendations

Ethyl formate Analytical Methods

Ethyl formate Specification

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