hydroxylamine
Conditions | Yield |
---|---|
With sodium hydroxide; 8-quinolinol; water at 20℃; for 3.66667h; Product distribution / selectivity; | 98% |
With 8-quinolinol; water; calcium oxide at 10 - 40℃; for 3.66667h; pH=3.8 - 12.3; Product distribution / selectivity; | 50% |
A
hydroxylamine
B
dinitrogen monoxide
C
trans-hyponitrous acid
Conditions | Yield |
---|---|
In water | A n/a B 90% C n/a |
cis-nitrous acid
A
hydroxylamine
B
dinitrogen monoxide
C
trans-hyponitrous acid
Conditions | Yield |
---|---|
In water | A n/a B 90% C n/a |
Conditions | Yield |
---|---|
With sulfuric acid Electrolysis; max. temp.:15°C;24 A,40 min,cooling,mixing; | 84% |
With sulfuric acid Electrolysis; 15-20 °C,cathode:Pb (amalgam surface);2.4 A,3.25 h; | 71.3% |
With sulfuric acid Electrolysis; mercury cathode,6 A,room temp.; | 66.1% |
Conditions | Yield |
---|---|
In dichloromethane Electrochem. Process; electrocatalytic redn. at Fe(III)(H2O)(TPPS)(3-)-modified electrode, pH 2.1, -0.9 V, 7.5 h; | A <1 B 84% C <1 D 8% |
With alkali metal amalgam In not given byproducts: alkali hydroxide; in dild. soln.,cooling,optimal yield for NH2OH; | |
With alkali metal amalgam In not given byproducts: alkali hydroxide; formation of N2O best at low temp., formation of N2 best at high temp., independent of the dilution; high yield of NH3 (and N2O2(2-)) obtained by agitation in a closed vessel or by dropping concd. nitrite soln. on excess aolid amalgame;; |
Conditions | Yield |
---|---|
With hydrogenchloride Electrolysis; lead cathode,coal anode,cooling of the anode surface,2.75 h,24 A; | 81% |
With sulfuric acid byproducts: Na2SO4; Electrolysis; lead electrodes,5 A,3.7-3.6 V,cooling; neutralization with NaOH,heating with acetone at 70-80°C,crystn. of Na2SO4 in 12 h,mixing with benzene,decompn. of the formed acetoxime with HCl,evapn.; | |
In water Electrolysis; Cu-cathode;; | 0% |
A
nitrogen
B
ammonia
C
hydroxylamine
D
dinitrogen monoxide
E
hydrazine
Conditions | Yield |
---|---|
In dichloromethane Electrochem. Process; electrocatalytic redn. at Fe(III)(PP)Cl-modified electrode, pH 2.1, -0.8 V, 1.0 h; | A 30% B 63% C 13% D <1 E <1 |
In dichloromethane Electrochem. Process; electrocatalytic redn. at Fe(III)(PP)Cl-modified electrode, pH 2.1, -0.9 V, 2.5 h; | A 35% B 52% C 13% D <1 E <1 |
In dichloromethane Electrochem. Process; electrocatalytic redn. at Fe(III)(PP)Cl-modified electrode, pH 2.1, -0.7 V, 4.0 h; | A 39% B 34% C 13% D 12% E 2% |
In dichloromethane Electrochem. Process; electrocatalytic redn. at Fe(III)(PP)Cl-modified electrode, pH 2.1, -0.6 V, 3.0 h; | A 35% B 31% C 16% D 18% E <1 |
In dichloromethane Electrochem. Process; electrocatalytic redn. at Fe(III)(H2O)(TMPyP)(5+)-modified electrode, pH 2.1, -0.9 V, 4.0 h; | A 14% B 27% C 13% D 32% E <1 |
hydroxylamine
Conditions | Yield |
---|---|
Electrolysis; 0°C,cylindrical zinc cathode,0.02 A/cm^2,from nitrite soln.; | 59.7% |
In water Electrolysis; with zinc cathode;various yields for various temp.; | |
With water In water byproducts: K2N2O2, NH3, N2; shaking of cold concd. nitrite soln. with K amalgam (39 g K + 2800 g Hg);; main product is K2N2O2;; | |
In water Electrolysis; with zinc cathode;various yields for various temp.; | |
With H2O; K amalgam In water |
Conditions | Yield |
---|---|
In butan-1-ol byproducts: NaCl; heating; crystn. at -10°C; | 50% |
Conditions | Yield |
---|---|
In ethanol byproducts: NaCl; 1.5-2 h; washing with waterfree ethanol,filtering,crystn.,filtering at -18°C; | 40% |
In ethanol byproducts: NaCl; outfreezing; | |
In ethanol byproducts: NaCl; reaction of suspn. of hydroxylammonium chloride with sodium ethoxide in abs. ethanol, NaCl pptn.; NaCl ppt. filtration off (glass filter); |
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide Electrolysis; bulk electrolysis of soln. containing NO, with CoTSPc-modified glassy carbon electrode, in the presence of TEAP as electrolyte, pH = 4-7; not isolated; | A 25% B n/a |
Conditions | Yield |
---|---|
In methanol byproducts: NaCl; filtering,distn. at reduced pressure; | 17% |
hydrogenchloride
3,4-bis((hydroxyimino)methyl)-1,2,5-oxadiazole 2-oxide
hydroxylamine
Conditions | Yield |
---|---|
α-isocyanilic acid; |
Conditions | Yield |
---|---|
higher-melting form; |
hydrogenchloride
1,3-dimethylvioluric acid
A
1,3-dimethylalloxan
B
hydroxylamine
hydrogenchloride
N-hydroxycamphorimide
A
D-(+)-camphoric acid
B
hydroxylamine
Conditions | Yield |
---|---|
at 140℃; |
A
3,5-diphenyl-1,2,4-oxadiazole-4-oxide
B
hydroxylamine
Conditions | Yield |
---|---|
With hydrogenchloride |
6-methoxy-benzofuran-2,3-dione-2-oxime
A
(2-hydroxy-4-methoxy-phenyl)-glyoxylic acid
B
hydroxylamine
4,5-dichloro-2-hydroxy-isoindoline-1,3-dione
A
3,4-dichloro-phthalic acid
B
hydroxylamine
pyrrole-2,5-dione monooxime
water
A
ammonia
B
hydroxylamine
hydrogenchloride
A
3,4-pyridinecarboxylic acid
B
ammonia
C
hydroxylamine
Conditions | Yield |
---|---|
at 150℃; |
hydrogenchloride
Metafulminuric acid
A
formic acid
B
hydrogen cyanide
C
ammonia
D
hydroxylamine
Metafulminuric acid
sulfuric acid
A
formic acid
B
hydrogen cyanide
C
ammonia
D
hydroxylamine
metafulminuric acid
A
formic acid
B
carbonic-acid
C
ammonia
D
hydroxylamine
Conditions | Yield |
---|---|
silver (I) ion In water catalytic oxydation in presence of AgCl at pH=7.2;; | 100% |
silver (I) ion In water catalytic oxydation in presence of AgI at pH=12.7;; | 91% |
silver (I) ion In water catalytic oxydation in presence of (Ag(S2O3)2)(3-) at pH=12.7;; | 89% |
2-formylbenzene boronic acid
hydroxylamine
1-hydroxy-1H-2,3,1,-benzoxazaborine
Conditions | Yield |
---|---|
In not given according to Dewar, M. J. S.; Dougherty, R. C. J. Am. Chem. Soc. 1964, 86, 433-436; | 99% |
Conditions | Yield |
---|---|
Stage #1: formaldehyd; hydroxylamine; phenylboronic acid In methanol; water at 0 - 20℃; for 18.1667h; Stage #2: potassium carbonate In methanol; water at 20℃; for 5h; | 99% |
formaldehyd
dihydroxy-methyl-borane
hydroxylamine
potassium carbonate
Conditions | Yield |
---|---|
Stage #1: formaldehyd; dihydroxy-methyl-borane; hydroxylamine In methanol; water at 0 - 20℃; for 18.1667h; Stage #2: potassium carbonate In methanol; water at 20℃; for 5h; | 97% |
hydroxylamine
[(P(o-tolyl)3Au)3(μ-NOH)]BF4
Conditions | Yield |
---|---|
In dichloromethane (N2); for 10 min; pptd. (Et2O); | 93% |
Conditions | Yield |
---|---|
In methanol; water at 0 - 20℃; for 18.1667h; | 92% |
formaldehyd
hydroxylamine
potassium carbonate
3-pyridylboronic acid
Conditions | Yield |
---|---|
Stage #1: formaldehyd; hydroxylamine; 3-pyridylboronic acid In methanol; water at 0 - 20℃; for 18.1667h; Stage #2: potassium carbonate In methanol; water at 20℃; for 5h; | 92% |
glyoxylic acid ethyl ester
hydroxylamine
ethyl 2-(hydroxyimino)acetate
Conditions | Yield |
---|---|
In toluene at 20℃; for 2h; Molecular sieve; | 90% |
hydroxylamine
Conditions | Yield |
---|---|
In dichloromethane; water under N2 atm. to soln. Ir complex in CH2Cl2 was added aq. hydroxylamine and stirred at room temp. for 2 h; soln. was evapd. to dryness in vacuo, residue was recrystd. from CH2Cl2-Et2O and dried; elem. anal.; | 90% |
Conditions | Yield |
---|---|
Stage #1: malononitrile With hydrogenchloride; sodium nitrite In water Cooling with ice; Stage #2: hydroxylamine In water Reflux; | 90% |
Conditions | Yield |
---|---|
Stage #1: hydroxylamine; methyl carbamate With sodium hydroxide In water at 5 - 30℃; Stage #2: 2-acetyl benzo[b]thiophene With methanol; sodium tetrahydroborate In tetrahydrofuran; water at 10 - 40℃; Stage #3: With hydrogenchloride; acetic acid at 40 - 45℃; for 3h; | 88% |
1-(2-chloroisonicotinyl)-1,3-butanedione
(3-methylphenyl)hydrazine hydrochloride
hydroxylamine
2-chloro-4-[1-(3-methylphenyl)-3-methyl-1H-pyrazol-5-yl]pyridine
Conditions | Yield |
---|---|
In ethanol | 87% |
Conditions | Yield |
---|---|
With Hg2(NO3)2 In not given byproducts: Hg; addn. of 0.04 M NH2OH to 0.005 M Hg2(NO3)2 soln. buffered with acetate at 20°C, autocatalysis of reaction by Hg;; | A 13% B 87% |
With Hg2(NO3)2; silver In not given byproducts: Hg; addn. of 0.04 M NH2OH to 0.005 M Hg2(NO3)2 soln. buffered with acetate at 20°C, autocatalysis of reaction by Hg, further catalysis by addn. of collodial Ag soln.;; | A 63% B 34% |
With oxygen In not given byproducts: water; Electrolysis; N2O formed on cathode, N2 formed on anode; |
hydroxylamine
Conditions | Yield |
---|---|
With ammonium acetate In ethanol at 100℃; under 12901.3 Torr; for 0.25h; Temperature; Microwave irradiation; | 87% |
Conditions | Yield |
---|---|
Stage #1: formaldehyd; hydroxylamine; boric acid In water at 0 - 20℃; for 18.1667h; Stage #2: potassium carbonate In methanol; water at 20℃; for 5h; | 86% |
dichloromethane
[Ru(CO)(OSO2CF3)((C2H5)2NCS2)(P(C6H5)3)2]
hydroxylamine
Conditions | Yield |
---|---|
In dichloromethane (N2); all manipulations were carried out using Schlenk techniques; addn. of 1 equiv. of hydroxylamine to soln. of (Ru(CO)(OTf)(Et2NCS2)(PPh3))in CH2Cl2, stirring at room temp. for 2 h; removal of solvent, recrystn. from CH2Cl2-hexane; elem. anal.; | 85% |
mer,trans-Re(η1-OSO2CF3)(CO)3(PPh3)2
hydroxylamine
[mer,trans-Re-(CO)3(NH2OH)(PPh3)2][SO3CF3]
Conditions | Yield |
---|---|
In dichloromethane elem. anal.; | 85% |
hydroxylamine
Conditions | Yield |
---|---|
In tetrahydrofuran; water at 120℃; for 12h; Inert atmosphere; Schlenk technique; regioselective reaction; | 85% |
[1-acetyl-1'-(2-aminopyrimidin-4-yl)]ferrocene
hydroxylamine
(C5H4C(CH3)NOH)Fe(C5H4C4H2N2(NH2))
Conditions | Yield |
---|---|
In ethanol; water to soln. of Fe complex in EtOH was added aq. soln. of hydroxylamine; mixt. was refluxed for 4 h with stirring; mixed with H2O; solvent removed (vac.); residue dissolved in water; extd. (ethyl acetate); org. layer washed (H2O); dried (anhyd. Na2SO4); concd.; subjected to chromy. (benzene-CHCl3. (2:1) as eluent); elem. anal.; | 84% |
hydroxylamine
Conditions | Yield |
---|---|
With ammonium acetate In ethanol at 100℃; under 12901.3 Torr; for 0.25h; Temperature; Microwave irradiation; | 84% |
iron(III)octaethylporphyrin chloride
hydroxylamine
octaethylporphyrin iron(II) nitrosyl
Conditions | Yield |
---|---|
In methanol; dichloromethane at 20℃; for 0.5h; Schlenk technique; | 84% |
In methanol; dichloromethane at 20℃; for 0.5h; Inert atmosphere; | 83% |
Conditions | Yield |
---|---|
In ethanol Electrolysis; anodic dissolution of nickel electrodes, supporting salt: Et4NBr; evapn. of most of the solvent, filtered off, washed with CHCl3, dried under vac.; | 82% |
Chemistry informtion about Hydroxylamine (CAS NO.7803-49-8) is:
IUPAC Name: Hydroxylamine
Synonyms: Hydroxylamine,Freebase ; Hydroxylaminefree-Base ; Nh2oh ; Oxammonium ; Oxyammonia ; Fh-50 ; Fh-50tm ; Hydroxylamine
MF: H3NO
MW: 33.03
EINECS: 232-259-2
Melting Point: 7°C
Density: 1.111 g/cm3
Boiling Point: 56.5 °C at 760 mmHg
Vapour Pressure: 179 mmHg at 25°C
Enthalpy of Vaporization: 34.9 kJ/mo
Refractive Index: n20/D 1.393
Merck: 13,4853
Stability: Stable. Incompatible with oxidizing agents, potassium dichromate, chromium trioxide, zinc, calcium, copper, sodium, ammonia, carbonyls, phosphorus halides, pyridine, hypochlorites.
Following is the molecular structure of Hydroxylamine (CAS NO.7803-49-8) is:
Hydroxylamine (CAS NO.7803-49-8) and its salts are commonly used as reducing agents in a myriad of organic and inorganic reactions. They can also act as antioxidants for fatty acids. Some non-chemical uses include removal of hair from animal hides and photography developing solutions. It can also be used to highly selectively cleave asparaginyl-glycine peptide bonds in peptides and proteins. It also bonds to and permanently disables (poisons) heme-containing enzymes. It is used as an irreversible inhibitor of the oxygen-evolving complex of photosynthesis on account of its similar structure to water.
NH2OH can be synthesized via several routes.
The first route is via Raschig synthesis: aqueous ammonium nitrite is reduced by HSO4− and SO2 at 0°C to yield a hydroxylamido-N,N-disulfate anion:
NH4NO2 + 2 SO2 + NH3 + H2O → 2 NH4+ + N(OH)(OSO2)22−
This anion is then hydrolyzed to give (NH3OH)2SO4:
N(OH)(OSO2)22− + H2O → NH(OH)(OSO2)− + HSO4−
2 NH(OH)(OSO2)− + 2 H2O → (NH3OH)2SO4
Solid NH2OH can be collected by treatment with liquid ammonia. Ammonium sulfate, (NH4)2SO4, a side-product insoluble in liquid ammonia, is removed by filtration; the liquid ammonia is evaporated to give the desired product.Another route is to make hydroxylammonium salts which can then be converted to hydroxylamine.
(NH3OH)Cl + NaOBu → NH2OH + NaCl + BuOH
Hydroxylamine can also be produced by the reduction of nitrous acid or potassium nitrate with bisulfite:
HNO2 + 2 HSO3− → N(OH)(OSO2)22− + H2O → NH(OH)(OSO2)− + HSO4−
NH(OH)(OSO2)− + H3O+ (100 °C/1 h) → NH3(OH)+ + HSO4−
1. | mmo-omi 1 mg/L | MUREAV Mutation Research. 74 (1980),113. | ||
2. | slt-dmg-unr 45 mmol/L/48H | MUREAV Mutation Research. 120 (1983),233. | ||
3. | dni-hmn:hla 10 mmol/L | MUREAV Mutation Research. 93 (1982),447. | ||
4. | sce-ham:lng 5 mmol/L | HUGEDQ Human Genetics. 54 (1980),155. | ||
5. | ipr-rat LD50:59 mg/kg | CNREA8 Cancer Research. 26 (1966),1448. | ||
6. | scu-rat LD50:29 mg/kg | JPETAB Journal of Pharmacology and Experimental Therapeutics. 119 (1957),444. | ||
7. | ipr-mus LD50:60 mg/kg | JPETAB Journal of Pharmacology and Experimental Therapeutics. 165 (1969),30. |
Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.
A poison by intraperitoneal and subcutaneous routes. A corrosive irritant to the eyes, skin, and mucous membranes. Locally it is irritating, and systemically it can cause methemoglobinemia. Human mutation data reported. Dangerous fire hazard when exposed to heat, flame, and oxidizers. May ignite spontaneously in air if a large surface area is exposed (e.g., precipitate on paper). Explodes in air when heated above 70°C. Explosive reaction with potassium dichromate, chromium trioxide, powdered zinc + heat. Forms the heat-sensitive explosive bis(hydroxylamide) in reaction with zinc or calcium. Ignites on contact with copper(II) sulfate, metals (e.g., sodium), oxidants (e.g., barium peroxide, barium oxide, lead dioxide, potassium permanganate, chlorine), phosphorus chlorides (e.g., phosphorus trichloride, phosphorus pentachloride). Incompatible with carbonyls, pyridine. Vigorous reaction with hypochlorites. When heated to decomposition it emits toxic fumes of NOx. See also AMINES.
Hazard Codes:
Xn: Harmful
N: Dangerous for the environment
Risk Statements:
R5: Heating may cause an explosion.
R22: Harmful if swallowed.
R37/38: Irritating to respiratory system and skin.
R41: Risk of serious damage to the eyes.
R43: May cause sensitization by skin contact.
R48/22: Harmful: danger of serious damage to health by prolonged exposure if swallowed.
R50: Very toxic to aquatic organisms.
Safety Statements:
S23: Do not breathe vapour.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
S47: Keep at temperature not exceeding...
S61: Avoid release to the environment. Refer to special instructions / safety data sheets.
S22: Do not breathe dust.
RIDADR: UN 3082 9/PG 3
WGK Germany: 3
F:
F 4.8: Do not heat over 80°C.
HazardClass: 8
PackingGroup: II
General description about Hydroxylamine (CAS NO.7803-49-8) ,it is a odorless white crystalline solid. Sinks and mixes with water.
Air & Water Reactions: Decomposes rapidly at room temperature or when dissolved in hot water by internal oxidation-reduction. Reacts with water or steam to produce heat and corrosive liquids.
Reactivity Profile: It is a white solid, thermally unstable, decomposes rapidly at room temperature or when dissolved in hot water by internal oxidation-reduction. It should be stored below 10° C [Bailar, 1973, vol. 2, p. 272]. Explosive reaction with strong oxidizers (chromium trioxide, potassium dichromate) or powdered zinc upon heat. Reaction with zinc or calcium produces explosive bishydroxylamides. It ignites on contact with cupric sulfate, alkali metals (sodium, potassium), oxidants (e.g., barium oxide, barium peroxide, lead dioxide, potassium permanganate, chlorine), phosphorus trichloride and pentachloride. It reacts vigorously with hypochlorites, pyridine, carbonyls [Sax, 9th ed., 1996, p. 1875]. On contact with organic materials in thin layer (e.g., crystals on filter paper), it may ignite spontaneously in air. It explodes when heated above 70° C [Brauer, 1963, vol. 1, p. 502]. During a distillation process, an explosion occurred. Potassium hydroxide is thought to be involved in the explosion. Employees in the plant complained of chest pains and suffered chemical burns. Five people were killed by the explosion.
Health Hazard: Inhalation: Moderately toxic by inhalation and oral routes with the following symptoms possible: headache, vertigo, tinnitus, dyspnea, nausea and vomiting, cyanosis, proteinuria and hematuria, jaundice, restlessness, and convulsion. Methemoglobinemia has been reported. Eyes: Corrosive - highly irritating. Skin: Irritating or corrosive to skin. Ingestion: Moderately toxic by inhalation and oral routes with the following symptoms possible; headache, vertigo, tinnitus, dyspnea, nausea and vomiting, cyanosis, proteinuria and hematuria, jaundice, restlessness, and convulsion. Methemoglobinemia has been reported.
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