Isomannide supplier | CasNO.641-74-7

Name
Isomannide
EINECS 211-374-1
CAS No. 641-74-7
Article Data50
CAS DataBase
Density 1.475 g/cm³
Solubility almost transparency
Melting Point 80-85 °C(lit.)
Formula C₆H₁₀O₄
Boiling Point 372.053 °C at 760 mmHg
Molecular Weight 146.143
Flash Point 178.8 °C
Transport Information
Appearance Off White Crystals
Safety 22-24/25
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms Mannitol,1,4:3,6-dianhydro-, D- (8CI);Furo[3,2-b]furan, D-mannitol deriv.;(+)-Isomannide;1,4:3,6-Dianhydro-D-mannitol;1,4:3,6-Dianhydromannitol;Isomannide;NSC 270938;
PSA 58.92000
LogP -1.49420

Synthetic route

: 69-65-8
mannitol

: 641-74-7
1,4:3,6-dianhydro-D-mannitol

Conditions

Conditions	Yield
With 1,8-diazabicyclo[5.4.0]undec-7-ene; carbonic acid dimethyl ester In methanol at 90℃; for 24h; Time;	92%
With hydrogenchloride In water for 60h; Heating;	72%
With cation-exchange resin In 1,4-dioxane; ethyl acetate at 78 - 84℃; for 24h; Heating;	35%

: 69-65-8
mannitol

A: 641-74-7
1,4:3,6-dianhydro-D-mannitol

B: 27826-73-9
2,5-anhydro-D-glucitol

Conditions

Conditions	Yield
With Hβ zeolite at 139.84℃; for 3h;	A 63% B 12%

: 50-70-4
D-sorbitol

: 616-38-6
carbonic acid dimethyl ester

A: 641-74-7
1,4:3,6-dianhydro-D-mannitol

B: 641-74-7, 652-67-5, 5627-19-0, 24332-71-6, 28218-68-0, 28948-16-5, 28980-83-8, 89825-36-5, 124508-14-1, 151380-60-8
1,4:3,6-dianhydro-L-iditol

C: 5306-85-4
isosorbide dimethyl ether

Conditions

Conditions	Yield
With triethylamine In biphenyl at 90 - 200℃; under 63756.4 Torr; for 48h; Reagent/catalyst; Autoclave; Inert atmosphere;	A 14% B 26% C 60%

...Expand

: 69-65-8
mannitol

A: 641-74-7
1,4:3,6-dianhydro-D-mannitol

B: 7726-97-8
1,4-anhydro-D-mannitol

C: 27826-73-9
2,5-anhydro-D-glucitol

Conditions

Conditions	Yield
With sulfuric acid at 139.84℃; for 1h; Reagent/catalyst;	A 28% B 11% C 52%
With hydrogen fluoride; sodium methylate; acetic acid 1) 45 h, 20 deg C; Yield given. Multistep reaction;
With formic acid; hydrogen fluoride; water 1) 8 min, 20 deg C; Yield given. Multistep reaction;
With hydrogen fluoride; sodium methylate; acetic acid Product distribution; Mechanism; multistep reaction; effect of concentration and time, intermediate acyloxonium ions monitored by 13C-NMR;
With formic acid; hydrogen fluoride; water Product distribution; Mechanism; multistep reaction; effect of concentration and time, intermediate acyloxonium ions monitored by 13C-NMR;

...Expand

: 69-65-8
mannitol

A: 641-74-7
1,4:3,6-dianhydro-D-mannitol

B: 7726-97-8
1,4-anhydro-D-mannitol

C: 492-93-3
1,5-anhydro-D-mannitol

D: 27826-73-9
2,5-anhydro-D-glucitol

Conditions

Conditions	Yield
In water at 249.84℃; for 36h; Kinetics; Temperature; Time;	A n/a B 25% C 6% D 41%
With sulfuric acid In water at 104℃; Product distribution; Rate constant; reaction time dependence;

...Expand

: 69-65-8
mannitol

A: 641-74-7
1,4:3,6-dianhydro-D-mannitol

B: 7726-97-8
1,4-anhydro-D-mannitol

C: 41107-82-8
2,5-anhydro-D-mannitol

Conditions

Conditions	Yield
In water at 276.84℃; for 10h; Kinetics; Temperature;	A n/a B n/a C 40.5%

...Expand

: 69-65-8
mannitol

: 141-78-6
ethyl acetate

A: 73952-88-2
(3R,6R)-6-hydroxyhexahydrofuro[3,2 b]furan-3-yl acetate

B: 641-74-7
1,4:3,6-dianhydro-D-mannitol

Conditions

Conditions	Yield
With calcium sulfate In 1,4-dioxane at 78 - 84℃; for 120h; Heating;	A 11% B n/a

...Expand

: 69-65-8
mannitol

A: 641-74-7
1,4:3,6-dianhydro-D-mannitol

B: 492-93-3
1,5-anhydro-D-mannitol

Conditions

Conditions	Yield
With hydrogenchloride

: 7251-85-6
1,6-dichloro-2S,3S,4S,5S-hexanetetraol

: 641-74-7
1,4:3,6-dianhydro-D-mannitol

Conditions

Conditions	Yield
at 180℃; unter vermindertem Druck;

: 56-23-5
tetrachloromethane

: 69-65-8
mannitol

: 104-15-4
toluene-4-sulfonic acid

: 641-74-7
1,4:3,6-dianhydro-D-mannitol

Conditions

Conditions	Yield
at 140℃;

...Expand

: 7726-97-8
1,4-anhydro-D-mannitol

: 641-74-7
1,4:3,6-dianhydro-D-mannitol

Conditions

Conditions	Yield
With sulfuric acid unter vermindertem Druck;

: 82064-06-0
1,4:3,6-dianhydro-2,5-di-O-benzoyl-D-mannitol

: 641-74-7
1,4:3,6-dianhydro-D-mannitol

Conditions

Conditions	Yield
With methanol; ammonia

: 67-56-1
methanol

: 124-41-4
sodium methylate

: 54522-28-0, 66966-12-9, 67890-26-0, 76793-35-6, 107740-09-0
(3R,3aS,6R,6aS)-hexahydrofuro[3,2-b]furan-3,6-diyl bis(4-methylbenzenesulfonate)

: 641-74-7
1,4:3,6-dianhydro-D-mannitol

...Expand

: 69-65-8
mannitol

A: 641-74-7
1,4:3,6-dianhydro-D-mannitol

B: 7726-97-8
1,4-anhydro-D-mannitol

C: 492-93-3
1,5-anhydro-D-mannitol

D: 41107-82-8
2,5-anhydro-D-mannitol

Conditions

Conditions	Yield
With pyridine hydrochloride at 140℃; Product distribution;

...Expand

: 54522-28-0, 66966-12-9, 67890-26-0, 76793-35-6, 107740-09-0
(3R,3aS,6R,6aS)-hexahydrofuro[3,2-b]furan-3,6-diyl bis(4-methylbenzenesulfonate)

aq.-ethanolic KOH-solution: aq.-ethanolic KOH-solution

: 641-74-7
1,4:3,6-dianhydro-D-mannitol

: 60-29-7
diethyl ether

: 54522-28-0, 66966-12-9, 67890-26-0, 76793-35-6, 107740-09-0
(3R,3aS,6R,6aS)-hexahydrofuro[3,2-b]furan-3,6-diyl bis(4-methylbenzenesulfonate)

lithium alanate: lithium alanate

: 641-74-7
1,4:3,6-dianhydro-D-mannitol

...Expand

: 7664-41-7
ammonia

: 54522-28-0, 66966-12-9, 67890-26-0, 76793-35-6, 107740-09-0
(3R,3aS,6R,6aS)-hexahydrofuro[3,2-b]furan-3,6-diyl bis(4-methylbenzenesulfonate)

sodium: sodium

: 641-74-7
1,4:3,6-dianhydro-D-mannitol

...Expand

: 7647-01-0
hydrogenchloride

: 69-65-8
mannitol

: 641-74-7
1,4:3,6-dianhydro-D-mannitol

: 7647-01-0
hydrogenchloride

: 69-65-8
mannitol

: 96-23-1
1,3-Dichloro-2-propanol

: 641-74-7
1,4:3,6-dianhydro-D-mannitol

Conditions

Conditions	Yield
at 140℃;

...Expand

: 56-23-5
tetrachloromethane

: 69-65-8
mannitol

: 7664-93-9
sulfuric acid

: 641-74-7
1,4:3,6-dianhydro-D-mannitol

Conditions

Conditions	Yield
at 140℃;

...Expand

: 69-65-8
mannitol

A: 124379-13-1
3,6-anhydro-D-altritol

B: 641-74-7
1,4:3,6-dianhydro-D-mannitol

C: 7726-97-8
1,4-anhydro-D-mannitol

D: 27826-73-9
2,5-anhydro-D-glucitol

Conditions

Conditions	Yield
With 3 A molecular sieve at 260℃; for 2h; Product distribution; Further Variations:; Temperatures; reaction time;

...Expand

: 69-65-8
mannitol

: 116-11-0
2-Methoxypropene

A: 65729-81-9
2,5-anhydro-1,3-O-isopropylidene-D-glucitol

B: 641-74-7
1,4:3,6-dianhydro-D-mannitol

Conditions

Conditions	Yield
Stage #1: mannitol With hydrogenchloride for 48h; Heating; Stage #2: 2-Methoxypropene In acetone Title compound not separated from byproducts;

...Expand

: 69-65-8
mannitol

potassium persulfate: potassium persulfate

: 641-74-7
1,4:3,6-dianhydro-D-mannitol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: aqueous hydrochloric acid 2: sulfuric acid / unter vermindertem Druck View Scheme

: 57-50-1
Sucrose

: 641-74-7
1,4:3,6-dianhydro-D-mannitol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: Hydrogenation 2: concentrated aqueous hydrochloric acid View Scheme
Multi-step reaction with 2 steps 1: Hydrogenation 2: aqueous HCl View Scheme

: 652-67-5
Isosorbide

A: 641-74-7
1,4:3,6-dianhydro-D-mannitol

B: 641-74-7, 652-67-5, 5627-19-0, 24332-71-6, 28218-68-0, 28948-16-5, 28980-83-8, 89825-36-5, 124508-14-1, 151380-60-8
1,4:3,6-dianhydro-L-iditol

Conditions

Conditions	Yield
With Raney nickel
With Raney nickel
With 5% active carbon-supported ruthenium; hydrogen In water at 220℃; under 35253.5 Torr; for 3h; Catalytic behavior; Concentration; pH-value; Pressure; Reagent/catalyst; Temperature; Time;	A 5 %Spectr. B 60 %Spectr.

: 1707-77-3
1,2:5,6-di-O-isopropylidene-D-mannitol

: 641-74-7
1,4:3,6-dianhydro-D-mannitol

Conditions

Conditions	Yield
With hydrogen; sodium hydroxide In water at 180℃; under 87758.8 Torr; for 3h; Temperature;

: 69-65-8
mannitol

A: 641-74-7
1,4:3,6-dianhydro-D-mannitol

B: 7726-97-8
1,4-anhydro-D-mannitol

Conditions

Conditions	Yield
In water at 20℃; for 6h; Reagent/catalyst; UV-irradiation;	A 10 %Chromat. B 87 %Chromat.

: 17739-45-6, 59146-56-4
2-(2-bromoethoxy)tetrahydropyran

: 641-74-7
1,4:3,6-dianhydro-D-mannitol

: 121693-40-1
2,5-di-O-<2'-(tetrahydropyran-2-yloxy)ethoxy>-1,4:3,6-dianhydro-D-mannitol

Conditions

Conditions	Yield
With sodium hydroxide In dimethyl sulfoxide 1.) 50 deg C, 15 min, 2.) 50 deg C, 1 h, 3.) 70 deg C, 12 h;	100%
With sodium hydride In dimethyl sulfoxide 1.) 60 deg C, 12 h;	100%

: 641-74-7
1,4:3,6-dianhydro-D-mannitol

: 67831-31-6
1,4:3,6-dianhydro-2,5-dideoxy-2,5-dibromo-L-iditol

Conditions

Conditions	Yield
With 1H-imidazole; bromine; triphenylphosphine In acetonitrile for 72h; Heating;	100%
With 1H-imidazole; bromine; triphenylphosphine In acetonitrile for 48h; Heating;	83%

: 358-23-6
trifluoromethylsulfonic anhydride

: 641-74-7
1,4:3,6-dianhydro-D-mannitol

: 1186074-69-0
[(3R,3aS,6R,6aS)-6-(trifluoromethylsulfonyloxy)-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl]trifluoromethanesulfonate

Conditions

Conditions	Yield
With pyridine In dichloromethane at 0 - 20℃; Inert atmosphere;	100%
With pyridine In dichloromethane at 0 - 20℃; for 3h;	99%
With pyridine In dichloromethane at -10 - 0℃; for 2h;	95%

: 16611-68-0
6-chloro-dibenzo[d,f][1,3,2]-dioxaphosphepin

: 641-74-7
1,4:3,6-dianhydro-D-mannitol

: 221180-09-2
C30H24O8P2

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran for 3h; Ambient temperature;	99%

: 71941-98-5
3,3',5,5'-tetra-tert-butyl-1,1'-biphenyl-2,2'-diyl phosphorochloridite

: 641-74-7
1,4:3,6-dianhydro-D-mannitol

: C62H88O8P2

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran for 3h; Ambient temperature;	99%

: 98-59-9
p-toluenesulfonyl chloride

: 641-74-7
1,4:3,6-dianhydro-D-mannitol

: 54522-28-0, 66966-12-9, 67890-26-0, 76793-35-6, 107740-09-0
(3R,3aS,6R,6aS)-hexahydrofuro[3,2-b]furan-3,6-diyl bis(4-methylbenzenesulfonate)

Conditions

Conditions	Yield
	96%
With pyridine at 0℃; for 3h; Inert atmosphere;	92%
With triethylamine In dichloromethane at 20 - 50℃;	91.5%

: [(R)-1,1'-binaphthyl-2,2'-diyl]chlorophosphite

: 641-74-7
1,4:3,6-dianhydro-D-mannitol

: C46H32O8P2

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran for 3h; Ambient temperature;	96%

: 106-96-7
propargyl bromide

: 641-74-7
1,4:3,6-dianhydro-D-mannitol

: 1251569-85-3
1,4:3,6-dianhydro-2,5-di-O-propargyl-D-mannitol

Conditions

Conditions	Yield
Stage #1: 1,4:3,6-dianhydro-D-mannitol With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0℃; Inert atmosphere; Stage #2: propargyl bromide With 18-crown-6 ether In N,N-dimethyl-formamide; toluene; mineral oil at 20℃; for 2h; Inert atmosphere;	96%
Stage #1: 1,4:3,6-dianhydro-D-mannitol With sodium hydride In N,N-dimethyl-formamide at 0℃; for 0.5h; Inert atmosphere; Stage #2: propargyl bromide With tetrabutylammomium bromide In N,N-dimethyl-formamide Inert atmosphere;	82%

: 3282-30-2
pivaloyl chloride

: 641-74-7
1,4:3,6-dianhydro-D-mannitol

A: (1R,4R,5R,8R)-(+)-2,6-Dioxa-4-hydroxy-8-O-pivaloylbicyclo<3.3.0>octane

B: 2,2-Dimethyl-propionic acid (3R,3aR,6R,6aR)-6-(2,2-dimethyl-propionyloxy)-hexahydro-furo[3,2-b]furan-3-yl ester

Conditions

Conditions	Yield
With triethylamine In dichloromethane for 2h; Yields of byproduct given;	A 95% B n/a

...Expand

: 106-95-6
allyl bromide

: 641-74-7
1,4:3,6-dianhydro-D-mannitol

: 103536-97-6
(3R,3aR,6R,6aR)-3,6-bis(allyloxy)hexahydrofuro[3,2-b]furan

Conditions

Conditions	Yield
With potassium tert-butylate In N,N-dimethyl-formamide at 0 - 20℃; Inert atmosphere;	94%
With sodium hydroxide
With sodium hydroxide; acetone
With 1,4-dioxane; sodium hydroxide

: 641-74-7
1,4:3,6-dianhydro-D-mannitol

: 50720-99-5
(3S,3aS,6S,6aS)-3,6-dichlorohexahydrofuro[3,2-b]furan

Conditions

Conditions	Yield
With pyridine; thionyl chloride at 0 - 70℃; for 20h;	94%
With pyridine; thionyl chloride

: 201230-82-2
carbon monoxide

: 106-99-0
buta-1,3-diene

: 641-74-7
1,4:3,6-dianhydro-D-mannitol

: C24H34O6

Conditions

Conditions	Yield
With palladium diacetate; triphenylphosphine; benzoic acid In 1,4-dioxane at 90℃; under 30003 Torr; for 20h;	94%

...Expand

: 428-76-2
bis(trifluoromethanesulfonyl)methane

: 641-74-7
1,4:3,6-dianhydro-D-mannitol

: (3R,6R)-hexahydrofuro[3,2-b]furan-3,6-diyl bis-(trifluoromethanesulfonate)

Conditions

Conditions	Yield
With pyridine In dichloromethane at -10 - 20℃; for 4h;	93%

: 1119-51-3
bromopentene

: 641-74-7
1,4:3,6-dianhydro-D-mannitol

: (3R,3aR,6R,6aR)-3,6-bis(pent-4-en-1-yloxy)hexahydrofuro[3,2-b]furan

Conditions

Conditions	Yield
Stage #1: 1,4:3,6-dianhydro-D-mannitol With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0℃; for 0.5h; Inert atmosphere; Stage #2: bromopentene In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; Inert atmosphere;	91%

: 592-55-2
2-Bromoethyl ethyl ether

: 641-74-7
1,4:3,6-dianhydro-D-mannitol

: 121693-38-7
(3R,3aR,6R,6aR)-3,6-Bis-(2-ethoxy-ethoxy)-hexahydro-furo[3,2-b]furan

Conditions

Conditions	Yield
With sodium hydroxide In dimethyl sulfoxide 1.) 50 deg C, 15 min, 2.) 50 deg C, 1 h, 3.) 70 deg C, 12 h;	90%
With sodium hydroxide In dimethyl sulfoxide 1.) 60 deg C, 12 h;	90%

: 2032-35-1
Bromoacetaldehyde diethyl acetal

: 641-74-7
1,4:3,6-dianhydro-D-mannitol

: 121693-51-4
(3R,3aR,6R,6aR)-3,6-Bis-(2,2-diethoxy-ethoxy)-hexahydro-furo[3,2-b]furan

Conditions

Conditions	Yield
With sodium hydroxide In dimethyl sulfoxide 1.) 50 deg C, 15 min, 2.) 50 deg C, 1 h, 3.) 70 deg C, 12 h;	90%

: 2032-35-1
Bromoacetaldehyde diethyl acetal

: 641-74-7
1,4:3,6-dianhydro-D-mannitol

A: 121693-51-4
(3R,3aR,6R,6aR)-3,6-Bis-(2,2-diethoxy-ethoxy)-hexahydro-furo[3,2-b]furan

B: 121710-04-1
(3R,3aR,6R,6aR)-6-(2,2-Diethoxy-ethoxy)-hexahydro-furo[3,2-b]furan-3-ol

Conditions

Conditions	Yield
With sodium hydroxide In dimethyl sulfoxide 1.) 60 deg C, 12 h;	A 90% B 8%
With sodium hydride In dimethyl sulfoxide 1.) 50 deg C, 2 h, 2.) 70 deg C, 12 h;	A 29% B 20%

...Expand

: 65-85-0
benzoic acid

: 641-74-7
1,4:3,6-dianhydro-D-mannitol

: 3014-56-0
(3S,3aR,6S,6aR)-6-(benzoyloxy)hexahydrofuro[3,2-b]furan-3-yl benzoate

Conditions

Conditions	Yield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 25℃; for 21h; Mitsunobu reaction;	90%
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran for 21h;	88%
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 20℃;
With di-isopropyl azodicarboxylate; triphenylphosphine In dichloromethane at 0 - 20℃;
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 20℃; for 12h;

: 641-74-7
1,4:3,6-dianhydro-D-mannitol

: 2,2'-dihydroxy-3,3'-dimethyl-1,1'-biphenyl

: C34H32O8P2

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran for 3h; Ambient temperature;	89%

: 641-74-7
1,4:3,6-dianhydro-D-mannitol

: 920-46-7
Methacryloyl chloride

: 94116-50-4
isomannide bis-methacrylate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 24h;	89%

: (S)-(1,1'-binaphthyl-2,2'-dioxy)chlorophosphine

: 641-74-7
1,4:3,6-dianhydro-D-mannitol

: C46H32O8P2

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran for 3h; Ambient temperature;	87%

: 1641-40-3
pyrocatechol phosphorochloridite

: 641-74-7
1,4:3,6-dianhydro-D-mannitol

: 2-O-(2-thioxobenzo-1,3,2-dioxaphospholan-2-yl)-1,4:3,6-dianhydro-D-mannitol

Conditions

Conditions	Yield
Stage #1: pyrocatechol phosphorochloridite; 1,4:3,6-dianhydro-D-mannitol With triethylamine In N,N-dimethyl-formamide at 20℃; for 20h; Stage #2: With sulfur In N,N-dimethyl-formamide at 20℃; for 20h;	87%

: 641-74-7
1,4:3,6-dianhydro-D-mannitol

: 8-chloro-16H-dinaphtho[2,1-d:1‘,2’-g][1,3,2]dioxaphosphocine

: C48H36O8P2

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran for 3h; Ambient temperature;	86%

: 1079-66-9
chloro-diphenylphosphine

: 641-74-7
1,4:3,6-dianhydro-D-mannitol

: 2,5-bis(diphenylphosphinoyl)-1,4:3,6-dianhydro-D-mannitol

Conditions

Conditions	Yield
Stage #1: chloro-diphenylphosphine; 1,4:3,6-dianhydro-D-mannitol With triethylamine In N,N-dimethyl-formamide at 20℃; for 144h; Stage #2: With 1,3-dibromo-propane In N,N-dimethyl-formamide at 20℃; for 336h;	86%

: 109-89-7
diethylamine

: 641-74-7
1,4:3,6-dianhydro-D-mannitol

: 1,4:3,6-dianhydro-D-mannitol 2,5-bis(tetraethyldiamidophosphate)

Conditions

Conditions	Yield
Stage #1: 1,4:3,6-dianhydro-D-mannitol With triethylamine; trichlorophosphate In 1,4-dioxane at 10 - 20℃; Stage #2: diethylamine In 1,4-dioxane at 20 - 75℃; for 3h;	85%

: 5781-53-3
monomethyl oxalyl chloride

: 641-74-7
1,4:3,6-dianhydro-D-mannitol

: O,O'-((3R,6R)-hexahydrofuro[3,2-b]furan-3,6-diyl) dimethyl dioxalate

Conditions

Conditions	Yield
Stage #1: 1,4:3,6-dianhydro-D-mannitol With n-butyllithium In tetrahydrofuran at -78 - 20℃; for 2h; Stage #2: monomethyl oxalyl chloride In tetrahydrofuran at 0 - 20℃; for 48h;	84%
Stage #1: 1,4:3,6-dianhydro-D-mannitol With n-butyllithium In tetrahydrofuran at -78 - 30℃; for 2h; Stage #2: monomethyl oxalyl chloride In tetrahydrofuran at 0 - 30℃; for 48h;	84%

: 10349-57-2
Quinoline-6-carboxylic acid

: 641-74-7
1,4:3,6-dianhydro-D-mannitol

: (3R,3aR,6R,6aR)-hexahydrofuro[3,2-b]furan-3,6-di(−6-quinolin) carboxylate

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃; for 24h; Inert atmosphere;	84%

: 685-83-6
bis(diethylamino)chlorophosphine

: 641-74-7
1,4:3,6-dianhydro-D-mannitol

A: 1,4:3,6-dianhydro-D-mannite 2,5-(diethylamidothiophosphate)

B: 1,4:3,6-dianhydro-D-mannitol 2,5-bis(tetraethyldiamidophosphorothioate)

C: 1,4:3,6-dianhydro-2-O-bis(diethylamido)thiophosphoryl-D-mannitol

Conditions

Conditions	Yield
Stage #1: bis(diethylamino)chlorophosphine; 1,4:3,6-dianhydro-D-mannitol With triethylamine In 1,4-dioxane at 20℃; for 18h; Stage #2: With sulfur In 1,4-dioxane at 20℃; for 4h;	A n/a B n/a C 83%
Stage #1: bis(diethylamino)chlorophosphine; 1,4:3,6-dianhydro-D-mannitol With triethylamine In chloroform at 20℃; for 24h; Stage #2: With sulfur In chloroform at 20℃; for 4h;
Stage #1: bis(diethylamino)chlorophosphine; 1,4:3,6-dianhydro-D-mannitol With pyridine at 20℃; for 24h; Stage #2: With sulfur at 20℃; for 4h;

...Expand

: 17178-11-9
2-ethoxyethyl p-toluenesulfonate

: 641-74-7
1,4:3,6-dianhydro-D-mannitol

: 121693-38-7
(3R,3aR,6R,6aR)-3,6-Bis-(2-ethoxy-ethoxy)-hexahydro-furo[3,2-b]furan

Conditions

Conditions	Yield
With sodium hydroxide In dimethyl sulfoxide 1.) 50 deg C, 15 min, 2.) 50 deg C, 1 h, 3.) 70 deg C, 12 h;	82%
With sodium hydroxide In dimethyl sulfoxide 1.) 60 deg C, 12 h;	82%

Isomannide Specification

The D-Mannitol,1,4:3,6-dianhydro-, with CAS registry number 641-74-7, belongs to the following product categories: (1)Alcohols and Derivatives; (2)Heterocycles. It has the systematic name of 1,4:3,6-dianhydro-D-mannitol. And the chemical formula of this chemical is C₆H₁₀O₄. When use this chemical, do not breathe dust and avoid contact with skin and eyes.

Physical properties of D-Mannitol,1,4:3,6-dianhydro-: (1)ACD/LogP: -1.19; (2)# of Rule of 5 Violations: 0; (3)ACD/BCF (pH 5.5): 1; (4)ACD/BCF (pH 7.4): 1; (5)ACD/KOC (pH 5.5): 3; (6)ACD/KOC (pH 7.4): 3; (7)#H bond acceptors: 4; (8)#H bond donors: 2; (9)#Freely Rotating Bonds: 2; (10)Polar Surface Area: 58.92 Å²; (11)Index of Refraction: 1.562; (12)Molar Refractivity: 32.114 cm³; (13)Molar Volume: 99.011 cm³; (14)Polarizability: 12.731×10^-24cm³; (15)Surface Tension: 56.653 dyne/cm; (16)Enthalpy of Vaporization: 71.639 kJ/mol; (17)Vapour Pressure: 0 mmHg at 25°C.

You can still convert the following datas into molecular structure:
(1)SMILES: O[C@H]1[C@H]2OC[C@@H](O)[C@H]2OC1
(2)InChI: InChI=1/C6H10O4/c7-3-1-9-6-4(8)2-10-5(3)6/h3-8H,1-2H2/t3-,4-,5-,6-/m1/s1
(3)InChIKey: KLDXJTOLSGUMSJ-KVTDHHQDBJ
(4)Std. InChI: InChI=1S/C6H10O4/c7-3-1-9-6-4(8)2-10-5(3)6/h3-8H,1-2H2/t3-,4-,5-,6-/m1/s1
(5)Std. InChIKey: KLDXJTOLSGUMSJ-KVTDHHQDSA-N

Product Name

Isomannide

Synthetic route

Isomannide Specification

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