Conditions | Yield |
---|---|
With hydrogen In methanol; water at 140℃; under 30003 Torr; for 24h; Sealed tube; Autoclave; | 97% |
With [Zn(BH4)2(py)] In tetrahydrofuran for 0.8h; Heating; | 94% |
With poly(p-aminostyrene)-palladium(II); hydrogen In N,N-dimethyl-formamide at 70℃; under 760 Torr; for 6h; | 91% |
Conditions | Yield |
---|---|
In benzene-d6 at 20℃; for 24h; Cooling with liquid nitrogen; Sealed tube; Inert atmosphere; | A n/a B 97% C 74% |
Conditions | Yield |
---|---|
With ammonia; hydrogen at 153℃; under 760.051 Torr; Reagent/catalyst; | 90.69% |
With ammonia; nickel at 100℃; under 36775.4 - 55163.1 Torr; Hydrogenation; | |
With platinum on silica; ammonia at 240℃; Hydrogenation; |
Conditions | Yield |
---|---|
With hydrogen In para-xylene; isopropyl alcohol at 25℃; under 760.051 Torr; for 4h; | A 9% B 88% |
1,3-diisopropylurea
sodium p-toluenesulfonamide
A
N-(isopropylcarbamoyl)-4-methylbenzenesulfonamide
B
isopropylamine
Conditions | Yield |
---|---|
at 170℃; for 5h; Product distribution; other time;; | A 78.2% B n/a |
at 170℃; for 5h; | A 78.2% B n/a |
Conditions | Yield |
---|---|
With ammonium formate; zinc In methanol for 0.05h; Heating; | 70% |
With nickel Hydrogenation.unter verschiedenen Bedingungen; | |
With aluminium amalgam |
Conditions | Yield |
---|---|
A n/a B 65% | |
A n/a B 65% |
Conditions | Yield |
---|---|
With ammonia; hydrogen at 160℃; under 760.051 Torr; for 0.5h; Catalytic behavior; Reagent/catalyst; Flow reactor; Inert atmosphere; | A 59.9% B n/a C n/a |
With nitrogen; ammonia; hydrogen at 170℃; Concentration; Time; Reagent/catalyst; |
Bis-(trifluormethyl)-bis-(trifluormethoxy)-sulfuran
ethylamine
A
Carbonyl fluoride
B
hydrogen fluoride ethylamine
C
isopropylamine
Conditions | Yield |
---|---|
-78°C, 0.5 h; | A n/a B n/a C 56% |
Conditions | Yield |
---|---|
In benzene-d6 at 20℃; for 4h; Cooling with liquid nitrogen; Sealed tube; Inert atmosphere; | A 11% B 34% C 36% D 48% |
1,4-diisopropyl-1,4-diazabuta-1,3-diene
1,2-phenylenediacetonitrile
A
naphthalene-1,4-dicarbonitrile
B
isopropylamine
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide at 136℃; for 1h; | A 43% B n/a |
Conditions | Yield |
---|---|
With phosphoric acid; hydrogen In water at 79.84℃; under 7500.75 - 60006 Torr; for 4h; Concentration; Reagent/catalyst; | A 42.2% B n/a |
With sulfuric acid; hydrogen In water at 79.84℃; under 60006 Torr; for 2h; Catalytic behavior; Autoclave; |
Conditions | Yield |
---|---|
Stage #1: diisopropylamine With rhodium(III) tetra(p-sulfonato-phenyl)porphyrin; oxygen; benzaldehyde In methanol; water at 100℃; under 750.075 Torr; for 6h; Stage #2: With hydrogenchloride In methanol; water at 80℃; Catalytic behavior; | 31.2% |
ramifenazone
A
N-Phenyl-N-(2-methylaminopropionyl)carbamic acid
B
Methyltartronic acid anilide methylamide
C
isopropylamine
Conditions | Yield |
---|---|
In water for 1728h; Irradiation; | A 30% B 22.5% C n/a D 8% |
Conditions | Yield |
---|---|
Stage #1: Benzyl-isopropyl-amin With rhodium(III) tetra(p-sulfonato-phenyl)porphyrin; oxygen; benzaldehyde In methanol; water at 100℃; under 750.075 Torr; for 6h; Stage #2: With hydrogenchloride In methanol; water at 80℃; Catalytic behavior; | 18.1% |
Conditions | Yield |
---|---|
at 180 - 190℃; und Kochen des Reaktionsprodukts mit konz. HCl; |
2-iodo-propane
potassium cyanide
A
isopropylamine
B
diisopropylamine
Conditions | Yield |
---|---|
Behandeln des Reaktionsproduktes mit Salzsaeure; |
Conditions | Yield |
---|---|
With ethanol; hydrazine hydrate |
Conditions | Yield |
---|---|
With hydrogen; nickel at 180 - 200℃; |
propene
isopropylamine
Conditions | Yield |
---|---|
With ammonia; sodium at 270℃; under 735508 Torr; | |
With ammonia; sodium at 250℃; under 661957 Torr; | |
With ammonia | |
With ammonia at 250℃; under 661957 Torr; |
Conditions | Yield |
---|---|
With ammonia at 250℃; under 661957 Torr; |
Conditions | Yield |
---|---|
With monoisopropyl sulfate; ammonia at 200 - 250℃; under 51485.6 - 88260.9 Torr; |
Conditions | Yield |
---|---|
With monoisopropyl sulfate; ammonia at 200 - 250℃; under 120 - 51485.6 Torr; |
Conditions | Yield |
---|---|
With potassium hydroxide; bromine |
Conditions | Yield |
---|---|
With sodium amalgam; acetic acid |
1,3-dihydroxyacetone oxime
isopropylamine
Conditions | Yield |
---|---|
With sodium amalgam; acetic acid |
Conditions | Yield |
---|---|
With lithium aluminium tetrahydride; diethyl ether |
Conditions | Yield |
---|---|
With hydrogenchloride |
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 20℃; Cooling with ice; | 100% |
With potassium carbonate; triethylamine In dichloromethane at 0 - 20℃; for 12h; | 89.5% |
With triethylamine In dichloromethane at 20℃; for 2h; | 73% |
Conditions | Yield |
---|---|
at 20 - 100℃; for 0.133333h; microwave irradiation; | 100% |
at 20℃; for 2h; | 100% |
With magnesium sulfate In 1,2-dichloro-ethane at 60℃; for 18h; Glovebox; | 85% |
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0 - 20℃; for 14h; Inert atmosphere; | 100% |
With triethylamine In dichloromethane at 0 - 20℃; for 6h; Inert atmosphere; Schlenk technique; | 98% |
With triethylamine In dichloromethane at 0 - 20℃; for 6h; Inert atmosphere; Schlenk technique; | 98% |
isopropylamine
p-toluenesulfonyl chloride
N-isopropyl-p-toluenesulfonamide
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0 - 20℃; | 100% |
With pyridine; dmap In dichloromethane at 0 - 20℃; for 16h; | 99% |
With pyridine at 0 - 25℃; Inert atmosphere; Schlenk technique; | 99% |
isopropylamine
trifluoroacetic anhydride
2,2,2-trifluoro-N-(1-methylethyl)acetamide
Conditions | Yield |
---|---|
With pyridine; dmap In tetrahydrofuran at 20℃; for 15h; | 100% |
With diethyl ether | |
In diethyl ether | |
at 0℃; than Rt, 3 h; | |
In dichloromethane at 20℃; Inert atmosphere; Schlenk technique; Glovebox; |
isopropylamine
ethyl acrylate
3-isopropylaminopropionic acid ethyl ester
Conditions | Yield |
---|---|
In tetrahydrofuran; ethanol at 0 - 20℃; for 16h; | 100% |
In ethanol at 0 - 20℃; for 24h; | 100% |
With poly(ethylene glycol) 2000; ruthenium trichloride at 50℃; for 8h; aza-Michael addition; | 91% |
Conditions | Yield |
---|---|
for 18h; | 100% |
With sodium hydroxide |
2,4,6-Tris(4-methylphenoxy)-1,3,5-triazine
isopropylamine
(4,6-Bis-p-tolyloxy-[1,3,5]triazin-2-yl)-isopropyl-amine
Conditions | Yield |
---|---|
100% |
4-methoxy-benzaldehyde
isopropylamine
N-(2-propyl)-4-methoxybenzylideneamine
Conditions | Yield |
---|---|
In chloroform at 20℃; for 24h; | 100% |
at 20 - 100℃; for 0.133333h; microwave irradiation; | 85% |
at 20℃; for 48h; | 83% |
N,N-dimethyl-formamide dimethyl acetal
isopropylamine
N2-iso-propyl-N1,N1-dimethylformamidine
Conditions | Yield |
---|---|
at 60℃; | 100% |
1,1,1,3,3,3-hexachloro-propan-2-one
isopropylamine
A
chloroform
B
N-Isopropyl-2,2,2-trichloroacetamide
Conditions | Yield |
---|---|
In hexane | A n/a B 100% |
methyl crotonate
isopropylamine
methyl β-isopropylaminobutanoate
Conditions | Yield |
---|---|
zirconium(IV) chloride In acetonitrile at 30℃; under 750.06 Torr; for 24h; Product distribution; var. α,β-unsat. ester, catalyst, pressure, temp.; | 100% |
zirconium(IV) chloride In acetonitrile at 30℃; under 750.06 Torr; for 24h; | 100% |
In acetone for 30h; Heating; |
1,3-dibromo-pentan-2-one
isopropylamine
Bis-(N-isopropyl)pentane-1,2-diimine
Conditions | Yield |
---|---|
In pentane for 22h; | 100% |
With magnesium sulfate In pentane for 22h; Ambient temperature; | 96% |
pentachloroacetone
isopropylamine
A
chloroform
B
N-Isopropyl-2,2-dichloroacetamide
Conditions | Yield |
---|---|
In hexane for 0.5h; | A n/a B 100% |
(E)-4-Ethoxy-1,1,1-trifluoro-3-buten-2-one
isopropylamine
(Z)-1,1,1-Trifluoro-4-isopropylamino-but-3-en-2-one
Conditions | Yield |
---|---|
In acetonitrile Ambient temperature; | 100% |
Conditions | Yield |
---|---|
In methanol; dichloromethane at 20℃; for 2h; Inert atmosphere; | 100% |
In toluene at 150 - 160℃; for 6h; Inert atmosphere; | 97% |
In methanol; dichloromethane at 20℃; for 3h; | 83% |
for 4h; Heating; | 80% |
(S)-(1-naphthyl) glycidyl ether
isopropylamine
(S)-1-isopropylamino-3-(1-naphthyloxy)-2-propanol
Conditions | Yield |
---|---|
In water for 3h; Heating; | 100% |
In water for 1h; Heating; | 99% |
With Na-zeolite In acetonitrile at 20℃; for 12h; | 95% |
N,N-Dimethyl-2,4-bis(trifluoroacetyl)-1-naphthylamine
isopropylamine
2,2,2-Trifluoro-1-[4-isopropylamino-3-(2,2,2-trifluoro-acetyl)-naphthalen-1-yl]-ethanone
Conditions | Yield |
---|---|
In acetonitrile for 2h; Ambient temperature; | 100% |
N-ethoxycarbonylaminomethylphosphonic acid
isopropylamine
(Ethoxycarbonylamino-methyl)-phosphonic acid; compound with isopropylamine
Conditions | Yield |
---|---|
In ethanol | 100% |
Conditions | Yield |
---|---|
In methanol at 90℃; for 2h; | 100% |
N-Boc-cyclohexylnorstatin
isopropylamine
Boc-cyclohexylnorstatine isopropylamide
Conditions | Yield |
---|---|
With N-hydroxy-5-norbornene-2,3-dicarboximide; dicyclohexyl-carbodiimide In ethyl acetate Ambient temperature; | 100% |
N-Isopropyl-N-((1E,3E)-6,6,6-trifluoro-5-oxo-hexa-1,3-dienyl)-acetamide
isopropylamine
(3E,5E)-1,1,1-Trifluoro-6-isopropylamino-hexa-3,5-dien-2-one
Conditions | Yield |
---|---|
In acetonitrile for 4h; Ambient temperature; | 100% |
2-m-chlorobenzoyloxy-4-isopropyl-2H-1,4-thiazin-3-one
isopropylamine
4-Isopropyl-2-isopropylamino-4H-[1,4]thiazin-3-one
Conditions | Yield |
---|---|
for 24h; Ambient temperature; | 100% |
isopropylamine
(S)-(+)-1-chloro-3-(1-naphthyloxy)-2-propanol
(R)-propranolol hydrochloride
Conditions | Yield |
---|---|
With sodium hydroxide; water for 16h; Ambient temperature; | 100% |
(R)-(-)-1-chloro-2-acetoxy-3-(1-naphthyloxy)propane
isopropylamine
(S)-(-)-propanolol hydrochloride
Conditions | Yield |
---|---|
With sodium hydroxide; water for 16h; Ambient temperature; | 100% |
2-Chloro-3-<α-cyano-α-(benzimidazol-2-yl)methylene>3,4-dihydroquinoxaline
isopropylamine
1-Isopropyl-2-Amino-3-(benzimidazol-2-yl)pyrrolo<2,3-b>quinoxaline
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide at 130℃; for 4h; sealed ampul; | 100% |
(+/-)-threo 2,3-epoxy-1-phenylphospholane 1-oxide
isopropylamine
(1S,2R,3R)-2-Isopropylamino-1-oxo-1-phenyl-1λ5-phospholan-3-ol
Conditions | Yield |
---|---|
In methanol at 40℃; Ring cleavage; addition; | 100% |
at 40℃; for 48h; |
1-(octylthio)carbonyl-3-(tetrahydrofuryl)-5-fluorouracil
isopropylamine
5-fluoro-3-(tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
Conditions | Yield |
---|---|
In diethyl ether for 0.166667h; Ambient temperature; | 100% |
Toluene-4-sulfonic acid (S)-2-hydroxy-3-(2-methyl-3-nitro-phenoxy)-propyl ester
isopropylamine
<2R>-(+)-1-isopropylamino-3-(2-methyl-3-nitrophenoxy)-2-propanol
Conditions | Yield |
---|---|
In toluene for 10h; Heating; | 100% |
1-ethylthio-4,4-bis(trifluoroacetyl)-1,3-butadiene
isopropylamine
Conditions | Yield |
---|---|
In acetonitrile for 1h; Ambient temperature; | 100% |
Structure of Isopropylamine (CAS NO.75-31-0):
IUPAC Name: propan-2-amine
Empirical Formula: C3H9N
Molecular Weight: 59.1103
Index of Refraction: 1.389
Molar Refractivity: 19.44 cm3
Molar Volume: 82.1 cm3
Polarizability: 7.7×10-24cm3
Surface Tension: 22 dyne/cm
Density: 0.719 g/cm3
Enthalpy of Vaporization: 27.83 kJ/mol
Melting Point: -101 °C
Boiling Point: 30.9 °C at 760 mmHg
Vapour Pressure: 608 mmHg at 25°C
storage temp: 2-8°C
Water Solubility: soluble
Sensitive: Air Sensitive
Physical Appearance: colourless liquid
Stability: Stable. Extremely flammable - note low boiling point and low flash point. Readily forms explosive mixtures with air. Incompatible with strong oxidizing agents, acids, acid chlorides, acid anhydrides, perchloryl fluoride.
Isopropylamine (CAS NO.75-31-0) is an organic compound, an amine.The main uses of isopropylamine are as the salt component to Glyphosate acid for weed prevention .
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
guinea pig | LD50 | oral | 2700mg/kg (2700mg/kg) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 45(3), Pg. 79, 1980. | |
mammal (species unspecified) | LC50 | inhalation | 1800mg/m3 (1800mg/m3) | Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 14, Pg. 80, 1975. | |
mammal (species unspecified) | LD50 | unreported | 500mg/kg (500mg/kg) | Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 14, Pg. 80, 1975. | |
mouse | LCLo | inhalation | 7000ppm/40M (7000ppm) | Shell Chemical Company. Unpublished Report. Vol. -, Pg. 7, 1961. | |
mouse | LD50 | oral | 2200mg/kg (2200mg/kg) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 45(3), Pg. 79, 1980. | |
rabbit | LD50 | oral | 3200mg/kg (3200mg/kg) | GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" SKIN AND APPENDAGES (SKIN): HAIR: OTHER | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 45(3), Pg. 79, 1980. |
rabbit | LD50 | skin | 380mg/kg (380mg/kg) | Interagency Collaborative Group on Environmental Carcinogenesis, National Cancer Institute, Memorandum, June 17, 1974Vol. 17JUN1974, | |
rat | LC50 | inhalation | 4000ppm/4H (4000ppm) | Interagency Collaborative Group on Environmental Carcinogenesis, National Cancer Institute, Memorandum, June 17, 1974Vol. 17JUN1974, | |
rat | LD50 | oral | 111mg/kg (111mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA GASTROINTESTINAL: OTHER CHANGES | National Technical Information Service. Vol. OTS0542011, |
rat | LDLo | intraperitoneal | 50mg/kg (50mg/kg) | Farmakologiya i Toksikologiya Vol. 31, Pg. 238, 1968. |
Isopropylamine (CAS NO.75-31-0) can be obtained by aminating isopropyl alcohol with ammonia in presence of a nickel/copper or similar catalyst:
(CH3)2CHOH + NH3 → (CH3)2CHNH2 + H2O
Hazard Codes: F+,Xi
Risk Statements: 12-36/37/38
R12:Extremely flammable.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 16-26-29
S16:Keep away from sources of ignition.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S29:Do not empty into drains.
RIDADR: UN 1221 3/PG 1
WGK Germany: 1
RTECS: NT8400000
F: 34
HazardClass: 3
PackingGroup: I
Isopropylamine , its cas register number is 75-31-0. It also can be called 1-Methylethylamine ; 2-Amino-propaan ; 2-Amino-propano ; 2-Aminopropan ; 2-Aminopropane ; Isopropilamina ; Isopropylamine ; Monoisopropylamine ; Propanal, 2-amino- ; Propane, 2-amino- ; sec-Propylamine .
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