Methanesulfonic acid supplier

Name
Methanesulfonic acid
EINECS 200-898-6
CAS No. 75-75-2
Article Data152
CAS DataBase
Density 1.511 g/cm³
Solubility Miscible with water. Slightly miscible with benzene and toluene. Immiscible with paraffins.
Melting Point 19 °C
Formula CH₄O₃S
Boiling Point 167 °C (10 torr)
Molecular Weight 96.107
Flash Point >230 °F
Transport Information UN 3265 8/PG 2
Appearance colourless or light yellow liquid
Safety 26-36-45-1/2-36/37/39
Risk Codes 34-22
Molecular Structure
Hazard Symbols C
Synonyms Methanesulfonic Acid;Methanesulfonic acid;
PSA 62.75000
LogP 0.58480

Synthetic route

: 67-56-1
methanol

: 82220-45-9
methanesulfonic phosphoric anhydride, diisopropyl ester

A: 75-75-2
methanesulfonic acid

B: 26955-63-5, 129149-78-6
diisopropyl methyl phosphate

Conditions

Conditions	Yield
for 1h; Ambient temperature;	A 100% B 98%

...Expand

: 74-93-1
methylthiol

: 75-75-2
methanesulfonic acid

Conditions

Conditions	Yield
With dihydrogen peroxide; methanesulfonic acid In water at 40 - 110℃; for 10h;	100%
With dihydrogen peroxide In water at 35 - 45℃; for 10h;	100%
With nitric acid at 80℃; for 8h; Concentration; Temperature;	93.75%
With Mg(2+)O4V(3-)C19H42N(1+); dihydrogen peroxide In acetonitrile at 20 - 40℃; for 25h; Reagent/catalyst; Temperature;	63.9%

: 67-56-1
methanol

: 4972-37-6
methanesulfonic phosphoric anhydride, diethyl ester

A: 75-75-2
methanesulfonic acid

B: 867-17-4
diethyl methyl phosphate

Conditions

Conditions	Yield
for 1h; Ambient temperature;	A 91% B 99%

...Expand

: 2386-57-4
methanesulfonic acid sodium salt

: 75-75-2
methanesulfonic acid

Conditions

Conditions	Yield
With hydrogenchloride In water at 40℃; for 3h; Temperature;	98.4%

: 7143-01-3
Methanesulfonic anhydride

: 75-75-2
methanesulfonic acid

Conditions

Conditions	Yield
With sulfuric acid; dihydrogen peroxide at 10 - 50℃; under 60006 - 90009 Torr; for 10h; Inert atmosphere;	97%
Product distribution / selectivity;

: (1,1-dioxido-4-oxo-3-phenyl-4H-thiochromen-2-yl)methyl methanesulfonate

A: 75-75-2
methanesulfonic acid

B: 1033736-87-6
C16H10O3S

Conditions

Conditions	Yield
In chloroform-d1 for 0.216667h; Photolysis; Inert atmosphere;	A 96% B n/a

: 34557-54-5
methane

: 75-75-2
methanesulfonic acid

Conditions

Conditions	Yield
With sulfuric acid; alumina; sulfur trioxide; dihydrogen peroxide In water at 50℃; under 21002.1 - 75007.5 Torr; for 3.5h; Reagent/catalyst; Autoclave;	95%
With Methyl methanesulfonate; sulfur trioxide In fluorosulphonic acid at 50℃; under 75007.5 Torr; for 10h;	93%
With sulfur trioxide at 50℃; under 75007.5 Torr; Autoclave;	91%

: 624-92-0
Dimethyldisulphide

: 75-75-2
methanesulfonic acid

Conditions

Conditions	Yield
With nitric acid at 80℃; for 6h; Temperature;	93.8%
With Mg(2+)O4V(3-)C19H42N(1+); water; oxygen In acetonitrile at 90℃; under 30003 Torr; for 24h; Reagent/catalyst; Pressure; Temperature; Autoclave;	92%
With oxygen In methanol at 30 - 40℃; for 14h; Irradiation;	65%

: 1404369-05-6
1-(methanesulfonoyloxy)-2(1H)-quinolone

A: 75-75-2
methanesulfonic acid

B: 59-31-4, 70254-42-1
2-quinolone

Conditions

Conditions	Yield
In methanol; water Quantum yield; UV-irradiation; Photolysis;	A 90% B n/a

: 34557-54-5
methane

A: 75-75-2
methanesulfonic acid

B: 7143-01-3
Methanesulfonic anhydride

Conditions

Conditions	Yield
With sulfuric acid; sulfur trioxide; dihydrogen peroxide at 50℃; under 75007.5 Torr; Large scale;	A 82% B n/a

: 2949-92-0
methanethiosulfonic acid S-methyl ester

A: 64-18-6
formic acid

B: 75-75-2
methanesulfonic acid

C: 109-87-5
Dimethoxymethane

D: 107-31-3
Methyl formate

Conditions

Conditions	Yield
With oxygen In methanol Irradiation;	A n/a B 72% C n/a D n/a

...Expand

: 124-63-0
methanesulfonyl chloride

A: 7647-01-0
hydrogenchloride

B: 75-75-2
methanesulfonic acid

Conditions

Conditions	Yield
With water for 5h; Time; Large scale;	A n/a B 70.2%

: 80352-66-5
4-mesyloxy-2-methylbutene

A: 75-75-2
methanesulfonic acid

B: 78-79-5
isoprene

Conditions

Conditions	Yield
at 310℃; under 115 Torr; for 0.133333h; Rate constant; Thermodynamic data; var. of initial pressure, temp., Ea, with addition of propene, toluene;	A n/a B 62.3%

: 40671-34-9
4-methanesulfonyloxy-1-butene

A: 75-75-2
methanesulfonic acid

B: 106-99-0
buta-1,3-diene

Conditions

Conditions	Yield
at 300.2℃; under 88 Torr; for 0.2h; Rate constant; Thermodynamic data; var. of initial pressure, temp., Ea, with addition of propene, toluene;	A n/a B 47.8%

: 75-18-3
dimethylsulfide

A: 75-75-2
methanesulfonic acid

B: 67-71-0
dimethylsulfone

C: 27798-35-2
S-methyl thioformate

D: 67-68-5
dimethyl sulfoxide

Conditions

Conditions	Yield
With dihydrogen peroxide; oxygen at 10.85℃; under 750.06 Torr; Product distribution; Kinetics; Further Variations:; Temperatures; Oxidation; Photolysis;	A n/a B n/a C n/a D 46.3%

...Expand

: 120622-89-1
N-Trichloracetyl-dimesylamin

A: 75-75-2
methanesulfonic acid

B: 5347-82-0
dimesylamine

C: N-Mesyl-trichloracetyl-amin

Conditions

Conditions	Yield
With water In acetonitrile 1.) 40 deg C, 144 h, 2.) 60 deg C, 24 h;	A n/a B n/a C 26%

...Expand

: 624-92-0
Dimethyldisulphide

A: 75-75-2
methanesulfonic acid

B: 2949-92-0
methanethiosulfonic acid S-methyl ester

C: 75-93-4
methyl bisulfate

D: 666-15-9
methyl methanesulfinate

Conditions

Conditions	Yield
With oxygen In methanol at 30 - 40℃; for 9.5h; Irradiation; with Pyrex Filter;	A 7.1% B 6.2% C n/a D n/a

...Expand

: 123-91-1
1,4-dioxane

: 93-59-4
Perbenzoic acid

: 67-66-3
chloroform

: 408309-55-7
bis-methanesulfonyl-bis-methylsulfanyl-methane

A: 75-75-2
methanesulfonic acid

B: 4610-99-5
tris-methanesulfonyl-methane

...Expand

: 556-64-9
methyl thiocyanate

: 75-75-2
methanesulfonic acid

Conditions

Conditions	Yield
With nitric acid
With nitric acid
With hydrogenchloride; acetic acid at 30 - 40℃; elektrolytische Oxydation;
With calcium chloride

: 917-64-6
methyl magnesium iodide

: 75-75-2
methanesulfonic acid

Conditions

Conditions	Yield
With diethyl ether; sulfur dioxide man zersetzt das Reaktionsprodukt mit Wasser und erwaermt die waessr.Loesung mit Brom;

: 93-59-4
Perbenzoic acid

: 67-66-3
chloroform

: 6156-25-8
tetrathioorthocarbonic acid tetramethyl ester

A: 75-75-2
methanesulfonic acid

B: 4610-99-5
tris-methanesulfonyl-methane

...Expand

: 624-92-0
Dimethyldisulphide

A: 75-75-2
methanesulfonic acid

B: 7143-01-3
Methanesulfonic anhydride

Conditions

Conditions	Yield
With air; Nitrogen dioxide at 30 - 80℃;

: 26209-83-6
3-aminopropranesulfonic acid

: 75-75-2
methanesulfonic acid

Conditions

Conditions	Yield
With nitric acid at 200℃;

: 27153-10-2
trichloromethane sulfonic Acid

: 75-75-2
methanesulfonic acid

Conditions

Conditions	Yield
With amalgamated potassium
Durch elektrische Reduktion in neutraler Loesung;
bei der elektrolytischen Reduktion in neutraler Loesung;

: 505053-33-8
N,N'-bis-(4-methanesulfinyl-but-3-enyl)-urea

: 64-19-7
acetic acid

: 75-75-2
methanesulfonic acid

Conditions

Conditions	Yield
bei der Ozonolyse und folgenden Oxydation mit 30prozentig.H2O2; (-)-N.N'-bis-<4-methanesulfinyl-buten-(3)-yl>-urea;

: 77-78-1
dimethyl sulfate

: 75-75-2
methanesulfonic acid

Conditions

Conditions	Yield
With ammonium sulfite Behandeln des erhaltenen Ammonium-methansulfonats mit konz.Schwefelsaeure;
With methanol; sodium sulfite das Natriumsalz ensteht;
With water; sodium sulfite das Natriumsalz;
With Trifluoromethanesulfonyl fluoride

: 623-81-4
diethyl sulphite

: 74-88-4
methyl iodide

: 75-75-2
methanesulfonic acid

Conditions

Conditions	Yield
With potassium hydroxide

: 74-88-4
methyl iodide

: 75-75-2
methanesulfonic acid

Conditions

Conditions	Yield
With alkali sulfite
With acidic alkali sulfite
With ammonium bisulfite; water
With alkali sulfite

: 67-56-1
methanol

: 2404-05-9
O,O-diethyl S-methyl phosphorothioate

A: 75-75-2
methanesulfonic acid

B: 867-17-4
diethyl methyl phosphate

Conditions

Conditions	Yield
With 3-chloro-benzenecarboperoxoic acid

...Expand

: 71-23-8
propan-1-ol

: 2404-05-9
O,O-diethyl S-methyl phosphorothioate

A: 75-75-2
methanesulfonic acid

B: 814-22-2
diethyl n-propyl phosphate

Conditions

Conditions	Yield
With 3-chloro-benzenecarboperoxoic acid

...Expand

: 75-75-2
methanesulfonic acid

: 115-18-4
2-methyl-3-buten-2-ol

: 5952-75-0
Δ3-Isopentenyl methyl sulfide

: 100669-10-1
isopentenyl methyl prenyl sulfonium methane sulfonate

Conditions

Conditions	Yield
In dichloromethane for 72h; Ambient temperature;	100%

...Expand

: 75-75-2
methanesulfonic acid

: Bpoc-Ala-OMaq

: CH3SO3H*H-Ala-OMaq

Conditions

Conditions	Yield
In dichloromethane for 1h; Ambient temperature;	100%

: 75-75-2
methanesulfonic acid

: N-allyl-N-<4-<(4-amidinophenoxy)carbonyl>-α-methylcinnamoyl>glycine ethyl ester hydrochloride

: p-(p-amidinophenoxycarbonyl)-α-methylcinnamic acid N-allyl-N-ethoxycarbonylmethylamide methanesulphonate

Conditions

Conditions	Yield
In chloroform at 25℃; for 1h;	100%

: 75-75-2
methanesulfonic acid

: 64-17-5
ethanol

: trans-[4-(6-amidinobenzo[b]thiophen-2-carboxamido)cyclohexyloxy]acetic acid trifluoroacetate

: ethyl trans-[4-[(6-amidinobenzo[b]thien-2-yl)carbonylamino]cyclohexyloxy]acetate methanesulfonate

Conditions

Conditions	Yield
for 1h; Esterification; Heating;	100%

...Expand

: 75-75-2
methanesulfonic acid

: 183319-69-9
erlotinib hydrochloride

: N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine, methanesulfonic acid salt

Conditions

Conditions	Yield
Stage #1: erlotinib hydrochloride With sodium hydroxide In water; ethyl acetate at 60 - 70℃; pH=10 - 11; Stage #2: methanesulfonic acid In ethyl acetate Heating / reflux;	100%
Stage #1: erlotinib hydrochloride With sodium hydroxide In water; ethyl acetate pH=8 - 9; Stage #2: In isopropyl alcohol Stage #3: methanesulfonic acid at 62 - 70℃; for 34h;	93%
Stage #1: erlotinib hydrochloride With sodium hydrogencarbonate In dichloromethane; water Stage #2: In isopropyl alcohol Stage #3: methanesulfonic acid	69%
Stage #1: erlotinib hydrochloride With 50percent NaOH In water; ethyl acetate at 50℃; for 0.25h; Stage #2: methanesulfonic acid at 50℃; for 4h; Further stages.;	111.76 g

: 75-75-2
methanesulfonic acid

: 885609-08-5
(R)-benzyl 9-(1-acetylpiperidin-4-yl)-8-oxo-3,6,7,8,9,10-hexahydroazepino[3,4-e]indazol-7-ylcarbamate

: (R)-9-(1-acetylpiperidin-4-yl)-7-amino-6,7,9,10-tetrahydroazepino[3,4-e]indazol-8(3H)-one methanesulfonate

Conditions

Conditions	Yield
With methoxybenzene In diethyl ether; dichloromethane at 20℃; for 2.5h;	100%

: 75-75-2
methanesulfonic acid

: 67-56-1
methanol

Conditions

Conditions	Yield
With zeolite beads at 120 - 385℃; Product distribution / selectivity;	100%

: 7-{2-[4-(5-fluoro-3a,7a-dihydro-1H-indol-3-yl)-piperidin-1-yl]-ethyl}-4,5-dihydro-1H-pyrrolo[3,2,1-hi]indol-2-one

: 75-75-2
methanesulfonic acid

: 7-{2-[4-(5-fluoro-3a,7a-dihydro-1H-indol-3-yl)-piperidin-1-yl]-ethyl}-4,5-dihydro-1H-pyrrolo[3,2,1-hi]indol-2-one methanesulfonate

Conditions

Conditions	Yield
In tetrahydrofuran at 0℃; for 0.5h;	100%

: 7-{2-[4-(6-fluoro-3a,7a-dihydro-1H-indol-3-yl)-piperidin-1-yl]-ethyl}-4,5-dihydro-1H-pyrrolo[3,2,1-hi]indol-2-one

: 75-75-2
methanesulfonic acid

: 7-{2-[4-(6-fluoro-3a,7a-dihydro-1H-indol-3-yl)-piperidin-1-yl]-ethyl}-4,5-dihydro-1H-pyrrolo[3,2,1-hi]indol-2-one bismethanesulfonate

Conditions

Conditions	Yield
In tetrahydrofuran at 0℃; for 0.5h;	100%

: 690999-15-6
TD-6301

: 75-75-2
methanesulfonic acid

: 4-{N-[7-((3-(S)-1-carbamoyl-1,1-diphenylmethyl)pyrrolidin-1-yl)hept-1-yl]-N-(isopropyl)amino}-1-(4-methoxypyrid-3-ylmethyl)piperidine trimethanesulfonic acid salt

Conditions

Conditions	Yield
In water; acetonitrile pH=5;	100%
In acetonitrile pH=5;	100%

: benzyl 1-[4-(3-cyclohexyl-1-methyl-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)phenyl]-4-piperidinyl(methyl)carbamate

: 75-75-2
methanesulfonic acid

: 553670-59-0
3-Cyclohexyl-1-methyl-6-{4-[4-(methylamino)-1-piperidinyl]phenyl}-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one monomethanesulfonate

Conditions

Conditions	Yield
With hydrogen; 10% palladium on activated carbon In methanol at 20℃;	100%

: 75-75-2
methanesulfonic acid

: 625111-37-7
9-(3-O-benzyl-5-O-(methanesulfonyl)-4-C-[[(methanesulfonyl)oxy]methyl]-2-O-trifluormethanesulfonyl-α-L-threo-pentofuranosyl)-6-N-benzoyladenine

: 625111-44-6
1-(2',3'-epoxide-4-C-methanesulfonyloxymethyl-5-O-methanesulfonyl-2-deoxy-α-L-erythro-pentofuranosyl)-6-benzoyl adenine-9-yl

Conditions

Conditions	Yield
In 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran at 0 - 20℃;	100%

: 1-isopropylsulfonyl-2-amino-6-(2-(methyl)-5-(2,4-difluorophenyl)-imidazol-4-yl)-benzimidazole

: 75-75-2
methanesulfonic acid

: 1-isopropylsulfonyl-2-amino-6-(2-(methyl)-5-(2,4-difluorophenyl)-imidazol-4-yl)-benzimidazole methanesulfonate

Conditions

Conditions	Yield
In methanol; dichloromethane	100%

: 769944-57-2
(S)-1,4-di-(t-butoxycarbonyl)-2-(4-((R)-3-hydroxypyrrolidino)phenyl)piperazine

: 75-75-2
methanesulfonic acid

: 769944-58-3
(S)-1,4-di(t-butoxycarbonyl)-2-(4-((R)-3-(methansulfonyloxy)pyrrolidin-1-yl)phenyl)piperazine

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0℃; for 0.333333h;	100%

: 676494-41-0
6-[2-ethoxy-4-(3-methyl-butylamino-methyl)-phenoxy]nicotinamide

: 75-75-2
methanesulfonic acid

: 676495-42-4
6-[4-((3-methyl-butylamino)-methyl)-2-ethoxyphenoxy]nicotinamide methanesulfonate salt

Conditions

Conditions	Yield
In tetrahydrofuran	100%

: 75-75-2
methanesulfonic acid

: 885608-22-0
[9-(2,2-dimethyl-propyl)-8-oxo-3,6,7,8,9,10-hexahydro-2,3,9-triaza-(R)-cyclohepta[e]inden-7-yl]-carbamic acid benzyl ester

: 7-(R)-amino-9-(2,2-dimethyl-propyl)-6,7,9,10-tetrahydro-3H-2,3,9-triaza-cyclohepta[e]inden-8-one bismethanesulfonate

Conditions

Conditions	Yield
With methoxybenzene In dichloromethane at 20℃; for 2.5h;	100%
With methoxybenzene In diethyl ether; dichloromethane at 20℃; for 3h;	100%
With methoxybenzene In dichloromethane at 20℃; for 2.5h;	100%

: 75-75-2
methanesulfonic acid

: 885608-47-9
4-(7-(R)-benzyloxycarbonylamino-8-oxo-6,7,8,10-tetrahydro-3H-2,3,9-triaza-cyclohepta[e]inden-9-yl)-piperidine-1-carboxylic acid tert-butyl ester

: 885609-06-3
(R)-benzyl 8-oxo-9-(piperidin-4-yl)-3,6,7,8,9,10-hexahydroazepino[3,4-e]indazol-7-ylcarbamate methanesulfonate

Conditions

Conditions	Yield
With methoxybenzene In dichloromethane at 20℃; for 0.5h;	100%
With methoxybenzene In diethyl ether; dichloromethane at 20℃; for 1h;	100%
With methoxybenzene In diethyl ether; dichloromethane at 20℃; for 1h;	100%

: 844443-90-9
tert-butyl 4-(4-(2,6-dichlorobenzamido)-1H-pyrazole-3-carboxamido)piperidine-1-carboxylate

: 75-75-2
methanesulfonic acid

: 4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxylic acid piperidin-4-yl-amide methanesulphonic salt

Conditions

Conditions	Yield
In 1,4-dioxane at 80 - 105℃; for 1.5 - 25h; Industry scale;	100%
In 1,4-dioxane at 80 - 105℃; for 1 - 24h; Product distribution / selectivity;	99.4%
In 1,4-dioxane at 80 - 105℃; Product distribution / selectivity;	98.5%

: 75-75-2
methanesulfonic acid

: 890052-11-6
N-{4-[(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)(cyano)amino]phenyl}-N'-(5-methyl-pyridin-2-yl)pyrazine-2,3-dicarboxamide

: N-[4-(2-imino-1,3-oxazolidin-3-yl)phenyl]-N'-(5-methylpyridin-2-yl)pyrazine-2,3-dicarboxamide methanesulfonate

Conditions

Conditions	Yield
In acetonitrile at 20℃;	100%

: 75-75-2
methanesulfonic acid

: 890052-12-7
N-{4-[(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)(cyano)amino]phenyl}-N'-(5-cyanopyridin-2-yl)pyrazine-2,3-dicarboxamide

: N-(5-cyanopyridin-2-yl)-N'-[4-(2-imino-1,3-oxazolidin-3-yl)phenyl]pyrazine-2,3-dicarboxamide methanesulfonate

Conditions

Conditions	Yield
In acetonitrile at 20℃;	100%

: 6-{4-[5-(4-chloro-3-trifluoromethyl-phenylamino)-4H-[1,2,4]triazol-3-yl]-phenoxy}-pyrimidine-2,4-diamine

: 75-75-2
methanesulfonic acid

: 6-{4-[5-(4-chloro-3-trifluoromethyl-phenylamino)-4H-[1,2,4]triazol-3-yl]-phenoxy}-pyrimidine-2,4-diamine methanesulfonic acid salt

Conditions

Conditions	Yield
In methanol for 0.5h;	100%

: 75-75-2
methanesulfonic acid

: 503537-30-2
perphenazine N-Boc-4-aminobutyrate

: 4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-1-piperazineethyl 4-aminobutyryl ester trimesylate

Conditions

Conditions	Yield
In acetic acid butyl ester; acetonitrile at 40℃; for 16h; Product distribution / selectivity; Inert atmosphere; Industry scale;	100%
In acetonitrile at 40℃; for 5h;	98%
In acetone at 40℃; for 4h; Product distribution / selectivity;	83%

: 936241-19-9
1-{1-[1-(1-methyl-cyclopropanecarbonyl)-piperidin-4-yloxy]-isoquinolin-4-yl}-3-[5-(1-methyl-cyclopropyl)-2-p-tolyl-2H-pyrazol-3-yl]-urea

: 75-75-2
methanesulfonic acid

: 1-{1-[1-(1-methyl-cyclopropanecarbonyl)-piperidin-4-yloxy]-isoquinolin-4-yl}-3-[5-(1-methyl-cyclopropyl)-2-p-tolyl-2H-pyrazol-3-yl]-urea mesylate

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 1h; Product distribution / selectivity;	100%

: 75-75-2
methanesulfonic acid

: 122971-97-5
(CH3)3PBH2P(C6H5)2BH3

: 122953-48-4
(CH3)3PBH2P(C6H5)2BH2OSO2CH3

Conditions

Conditions	Yield
With potassium hydrogencarbonate In dichloromethane MeOSO3 added to a soln. of the borane, KHCO3 added, stirring, mixture passed through a column (silica gel, ethylacetate; concg. (vac.), elem. anal.;	100%

: 75-75-2
methanesulfonic acid

: 122953-49-5
(CH3)3PBH2P(C6H5)2BH2P(C6H5)2BH3

: 132140-40-0
(CH3)3PBH2P(C6H5)2BH2P(C6H5)2BH2SO3CH3

Conditions

Conditions	Yield
With potassium hydrogencarbonate In dichloromethane after 30 min reaction KHCO3 added, stirring; mixture passed through a column (silica gel, ethyl acetate), filtrate concentrated (vac.);	100%

: 75-75-2
methanesulfonic acid

: 1073969-87-5
(1S,2S)-2-(2-carbamoyl-5-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenylamino)cyclopentyl 2-(tert-butoxycarbonylamino)acetate

: 1073969-68-2
(1S,2S)-2-(2-carbamoyl-5-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenylamino)cyclopentyl 2-aminoacetate methanesulfonate

Conditions

Conditions	Yield
Stage #1: (1S,2S)-2-(2-carbamoyl-5-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenylamino)cyclopentyl 2-(tert-butoxycarbonylamino)acetate With trifluoroacetic acid In dichloromethane at 0℃; for 0.583333h; Stage #2: methanesulfonic acid In dichloromethane	100%

: 75-75-2
methanesulfonic acid

: 1078166-64-9
1-tert-butyl 3-ethyl 3-{[(6-methoxy-2-naphthyl)oxy]methyl}azetidine-1,3-dicarboxylate

: ethyl 3-{[(6-methoxy-2-naphthyl)oxy]methyl}azetidine-3-carboxylate mesylate

Conditions

Conditions	Yield
In Isopropyl acetate at 40℃; for 18h;	100%

: 616-47-7
1-methyl-1H-imidazole

: 75-75-2
methanesulfonic acid

: 630393-13-4
1-methylimidazolium methylsulfonate

Conditions

Conditions	Yield
at 20℃; for 5.5h; Cooling with ice;	100%
at 0 - 20℃;
at 20℃; Cooling with ice;

Methanesulfonic acid Specification

Methanesulfonic acid is a colorless liquid with the chemical formula CH₃SO₃H. It is the simplest of the alkylsulfonic acids. Salts and esters of methanesulfonic acid are known as mesylates. It is also called Methanesulphonic acid, methanesulphonic-acid-, Sulfomethane, CCRIS 2783, HSDB 5004. Methanesulfonic acid is used as an acid catalyst in organic reactions because it is non-volatile, strong acid that is soluble in organic solvents.Methanesulfonic acid toxic is people .It shoule be Keeped locked up and out of the reach of children.when you use it, you should wear suitable protective clothing. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. In case of accident or if you feel unwell, seek medical advice immediately (show label where possible).

Physical properties about Methanesulfonic acid are:
(1)ACD/LogP: -2.087; (2)ACD/LogD (pH 5.5): -5.39; (3)ACD/LogD (pH 7.4): -5.58; (4)ACD/BCF (pH 5.5): 1.00; (5)ACD/BCF (pH 7.4): 1.00; (6)ACD/KOC (pH 5.5): 1.00 ; (7)ACD/KOC (pH 7.4): 1.00; (8)#H bond acceptors: 3 ; (9)#H bond donors: 1; (10)Index of Refraction: 1.448; (11)Molar Refractivity: 17.019 cm³; (12)Molar Volume: 63.581 cm³; (13)Polarizability: 6.747 10-24cm³; (14)Surface Tension: 53.3790016174316 dyne/cm; (15)Density: 1.512 g/cm³

Preparation of Methanesulfonic acid:
A process for the preparation of methanesulfonic acid comprising reacting sulfite ions within an aqueous system with dimethyl sulfate at an elevated temperature and, subsequently, adding a strong acid, wherein the molar ratio of sulfite ions to dimethyl sulfate is 1.5 to 2.5:1, and the reaction is maintained at said elevated temperature for at least 2 h.

Uses of Methanesulfonic acid:
Methanesulfonic acid may be considered an intermediate compound between sulfuric acid (H₂SO₄), and methylsulfonylmethane ((CH₃)2SO₂), effectively replacing an -OH group with a -CH₃ group at each step. This pattern can extend no further in either direction without breaking down the -SO₂ group. Methanesulfonic acid can be used in the generation of BH₃. By reacting methanesulfonic acid with NaBH₄in an aprotic solvent such as THF or DMS, the complex of BH₃ and the solvent is formed.

You can still convert the following datas into molecular structure:
(1)InChI=1S/CH4O3S/c1-5(2,3)4/h1H3,(H,2,3,4);
(2)InChIKey=AFVFQIVMOAPDHO-UHFFFAOYSA-N;
(3)SmilesS(=O)(=O)(C)O;

The toxicity data of Methanesulfonic acid is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Source
guinea pig	LD50	skin	> 2gm/kg (2000mg/kg)	Kodak Company Reports. Vol. 21MAY1971,
quail	LD50	oral	1gm/kg (1000mg/kg)	Journal of Reproduction and Fertility. Vol. 48, Pg. 371, 1976.
rat	LC	inhalation	> 330ppm/6H (330ppm)	Kodak Company Reports. Vol. 21MAY1971,
rat	LD50	oral	200mg/kg (200mg/kg)	Kodak Company Reports. Vol. 21MAY1971,

Product Name

Methanesulfonic acid

Synthetic route

Methanesulfonic acid Specification

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