Methoxypropiophenone supplier

Name
Methoxypropiophenone
EINECS 204-512-7
CAS No. 121-97-1
Article Data223
CAS DataBase
Density 1.071 g/cm³
Solubility
Melting Point 27-29 °C(lit.)
Formula C₁₀H₁₂O₂
Boiling Point 272.316 °C at 760 mmHg
Molecular Weight 164.204
Flash Point 118.806 °C
Transport Information UN 1993
Appearance Clear colourless to amber liquid
Safety 24/25
Risk Codes
Molecular Structure
Hazard Symbols Xi
Synonyms p-Methoxypropiophenone;4-Methoxypropiophenone;Propiophenone,4'-methoxy- (6CI,7CI,8CI);Propiophenone, p-methoxy- (4CI);1-(4-Methoxyphenyl)-1-propanone;1-Methoxy-4-propanoylbenzene;4-Propanoylanisole;4'-Methoxypropiophenone;Ethyl 4-methoxyphenyl ketone;Ethyl p-methoxyphenyl ketone;NSC 11834;
PSA 26.30000
LogP 2.28790

Synthetic route

: 79-03-8
propionyl chloride

: 100-66-3
methoxybenzene

: 121-97-1
4-Methoxypropiophenone

Conditions

Conditions	Yield
With Noccaea caerulescens extract supported in montmorillonite K10 at 60℃; for 6h; Friedel Crafts acylation; Inert atmosphere; regioselective reaction;	100%
With aluminum (III) chloride In dichloromethane at 5 - 20℃; for 2.5h;	98%
With benzyltributylammonium tetrachloroferrate at 50℃; for 0.1h; Friedel-Crafts reaction;	93%

: 100-66-3
methoxybenzene

: 123-62-6
propionic acid anhydride

: 121-97-1
4-Methoxypropiophenone

Conditions

Conditions	Yield
With lithium perchlorate at 60℃; for 1h;	99%
Stage #1: methoxybenzene; propionic acid anhydride With modified ZSM-5 zeolite at 100℃; for 5h; Stage #2: at 500℃; for 2h; Temperature; Calcination;	97.6%
With hafnium(IV) trifluoromethanesulfonate; lithium perchlorate In nitromethane for 6h; Ambient temperature;	93%

: 51410-44-7
1-(4-methoxylphenyl)-2-propen-1-ol

: 121-97-1
4-Methoxypropiophenone

Conditions

Conditions	Yield
With tris(acetonitrile)pentamethylcyclopentadienylruthenium(II) hexafluorophosphate; potassium carbonate In acetonitrile for 1h; Inert atmosphere; Reflux;	99%
With [Ru(η(3):η(3)-C10H16)Cl(O2CCH3)] In aq. phosphate buffer at 50℃; for 1h; pH=7; Sealed tube; Inert atmosphere;	99%
With Fe(II)(bis(2-(diisopropylphosphino)ethyl)amine)(CO)(H)(Cl); potassium tert-butylate In toluene at 80℃; for 1h; Inert atmosphere;	98%

: 97-94-9
triethyl borane

: 4-methoxy-N-phenyl-N-tosylbenzamide

: 121-97-1
4-Methoxypropiophenone

Conditions

Conditions	Yield
With [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride; potassium carbonate In tetrahydrofuran; tert-butyl methyl ether at 20℃; for 24h; Inert atmosphere; Schlenk technique;	99%

: 75-57-0
tetramethlyammonium chloride

: 70-70-2
4-hydroxypropiophenone

: 121-97-1
4-Methoxypropiophenone

Conditions

Conditions	Yield
With potassium carbonate In 1,2-dimethoxyethane at 145℃; for 0.416667h; Microwave irradiation; Inert atmosphere; Sealed vessel;	98%
With potassium carbonate at 150 - 160℃; for 4h;	81%

: 92409-14-8
C17H20O4

: 121-97-1
4-Methoxypropiophenone

Conditions

Conditions	Yield
With 5%-palladium/activated carbon; ammonium formate In ethanol; water at 80℃; for 1h;	98%

: 5349-60-0
1-(4-methoxyphenyl)-1-propanol

A: 623-12-1
4-chloromethoxybenzene

B: 121-97-1
4-Methoxypropiophenone

Conditions

Conditions	Yield
With dichloromethane extract derived from 6percent aqueous hypochlorite/tetra-n-butylammonium bisulfate solution with pH value to 8-9 In dichloromethane at 20℃;	A 92% B 6%

: 77-78-1
dimethyl sulfate

: 70-70-2
4-hydroxypropiophenone

: 121-97-1
4-Methoxypropiophenone

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile for 20.5h; Heating / reflux;	89%
With sodium hydroxide
With hydroxide

: 94607-41-7
(E)-1-(4-methoxyphenyl)-3-chloropropene

: 121-97-1
4-Methoxypropiophenone

Conditions

Conditions	Yield
With potassium carbonate; phenylboronic acid; [Ru(cyclopentadienyl)(MeCN)3]PF6 In acetonitrile at 20℃; for 16h;	89%
With cyclopentadienylruthenium(II) trisacetonitrile hexafluorophosphate; potassium carbonate; phenylboronic acid In acetonitrile at 20℃; for 24h; Inert atmosphere; regioselective reaction;	89%

: 52898-49-4
4,N-dimethoxy-N-methylbenzamide

: 925-90-6
ethylmagnesium bromide

: 121-97-1
4-Methoxypropiophenone

Conditions

Conditions	Yield
In tetrahydrofuran at 0 - 5℃; for 1h; Weinreb Ketone Synthesis; Inert atmosphere;	89%

: 67-56-1
methanol

: 3319-15-1
rac-1-(4-methoxyphenyl)-ethanol

: 121-97-1
4-Methoxypropiophenone

Conditions

Conditions	Yield
With chlorine[2-(4,5-dihydro-1H-imidazol-2-yl)-6-methoxypyridine](pentamethylcyclopentadienyl)iridium(III) chloride; potassium hydroxide In water at 80℃; Schlenk technique; Inert atmosphere;	89%
With chlorine[2-(4,5-dihydro-1H-imidazol-2-yl)-6-methoxypyridine](pentamethylcyclopentadienyl)iridium(III) chloride; potassium hydroxide In water at 80℃; for 16h; Schlenk technique; Inert atmosphere; chemoselective reaction;	89%

: 79-03-8
propionyl chloride

: 100-66-3
methoxybenzene

A: 5561-92-2
1-(2-methoxyphenyl)propan-1-one

B: 121-97-1
4-Methoxypropiophenone

Conditions

Conditions	Yield
With zeolite H-beta at 69.85℃; for 2h; Product distribution; Further Variations:; Temperatures; Reagents; Acylation;	A 11.88% B 85.37%

...Expand

: 104-45-0
4-n-propylanisole

: 121-97-1
4-Methoxypropiophenone

Conditions

Conditions	Yield
With dipotassium peroxodisulfate; copper(I) sulfate In water; acetonitrile at 65 - 70℃; for 3h;	85%
With formic acid; water; 2,3-dicyano-5,6-dichloro-p-benzoquinone In 1,4-dioxane at 110 - 120℃; for 0.266667h; microwave irradiation;	66%
With Bromotrichloromethane; Ir[2-(2,4-difluorophenyl)-5-(trifluoromethyl)pyridine]2(4,4'-di-tert-butyl-2,2'-bipyridine)PF6; water; potassium carbonate In acetonitrile at 20℃; Irradiation; Inert atmosphere; regioselective reaction;	60%

: 4180-23-8
E-1-(4'-methoxyphenyl)prop-1-ene

: 121-97-1
4-Methoxypropiophenone

Conditions

Conditions	Yield
With tetrafluoroboric acid; oxygen; palladium diacetate; p-benzoquinone In N,N-dimethyl acetamide; water; acetonitrile at 20℃; for 16h; regioselective reaction;	84%

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: 100-06-1
1-(4-methoxyphenyl)ethanone

: 121-97-1
4-Methoxypropiophenone

Conditions

Conditions	Yield
With ammonium peroxydisulfate; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer In water at 110℃; for 3h; Reagent/catalyst; Solvent; Inert atmosphere; Sealed tube;	84%

: 557-20-0
diethylzinc

: 123-11-5
4-methoxy-benzaldehyde

: 121-97-1
4-Methoxypropiophenone

Conditions

Conditions	Yield
With pivalaldehyde; magnesium bromide In tetrahydrofuran; toluene at 0 - 20℃; for 2h; Inert atmosphere;	84%

: C2H5BrMg*C2H6OZn*LiCl

: 123-11-5
4-methoxy-benzaldehyde

: 121-97-1
4-Methoxypropiophenone

Conditions

Conditions	Yield
With pivalaldehyde In tetrahydrofuran at 0 - 20℃; for 2h; Inert atmosphere;	84%

: 557-20-0
diethylzinc

: 123-11-5
4-methoxy-benzaldehyde

A: 5349-60-0
1-(4-methoxyphenyl)-1-propanol

B: 121-97-1
4-Methoxypropiophenone

Conditions

Conditions	Yield
With pivalaldehyde; lithium chloride; magnesium bromide In tetrahydrofuran at 0 - 20℃; Reagent/catalyst; Inert atmosphere; chemoselective reaction;	A n/a B 82%

...Expand

: 108-24-7
acetic anhydride

: 100-66-3
methoxybenzene

: 123-62-6
propionic acid anhydride

: 121-97-1
4-Methoxypropiophenone

Conditions

Conditions	Yield
aluminum(III) hydrogen sulfate In nitromethane at 65 - 70℃; for 2h;	80%

...Expand

: 91564-39-5
2-dimethylamino-1-(4-methoxy-phenyl)-propan-1-one

: 121-97-1
4-Methoxypropiophenone

Conditions

Conditions	Yield
With acetic acid; zinc at 20℃; for 1h;	77%

: 121-97-1
4-Methoxypropiophenone

: 21086-33-9
2-bromo-1-(4-methoxyphenyl)-1-propanone

Conditions

Conditions	Yield
With bromine at 20℃; for 0.333333h;	100%
With bromine In diethyl ether at 20℃;	100%
With bromine In acetic acid	99%

: 121-97-1
4-Methoxypropiophenone

: 24316-59-4
p-Methoxypropiophenone oxime

Conditions

Conditions	Yield
With hydroxylamine hydrochloride	100%
With hydroxylamine hydrochloride; triethylamine In ethanol for 3h; Reflux;	100%
With ethanol; hydroxylamine

: 121-97-1
4-Methoxypropiophenone

: 24316-59-4
1-(4-methoxyphenyl)propan-1-one oxime

Conditions

Conditions	Yield
With hydroxylamine hydrochloride; sodium acetate In methanol Heating;	100%
With hydroxylamine hydrochloride; potassium carbonate In ethanol Heating;	87%
With hydroxylamine hydrochloride; sodium acetate In methanol at 70℃; for 2h;
With hydroxylamine hydrochloride; potassium carbonate In methanol at 20℃; for 16h; Inert atmosphere;

: 623-12-1
4-chloromethoxybenzene

: 121-97-1
4-Methoxypropiophenone

: 35258-41-4
1,2-bis-(4-methoxy-phenyl)-propan-1-one

Conditions

Conditions	Yield
With 2-methoxy-6-(N-methyl-N-phenyl-amino)phenyl(dicyclohexyl)phosphine; palladium diacetate; sodium t-butanolate In toluene at 110℃; for 18h; Schlenk technique; Inert atmosphere;	100%
With PdCl2(C3H3N2(CH3))(C3H2N2(C6H3(C3H7)2)2); potassium tert-butylate In toluene at 80℃; for 6h; Inert atmosphere;	89%
With C40H44ClN3Pd; sodium t-butanolate In toluene at 80℃; for 3h; Inert atmosphere;	87%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 121-97-1
4-Methoxypropiophenone

: tert-butyl((1-(4-methoxyphenyl)prop-1-en-1-yl)oxy)dimethylsilane

Conditions

Conditions	Yield
Stage #1: 4-Methoxypropiophenone With potassium hexamethylsilazane In tetrahydrofuran at -78℃; for 0.5h; Inert atmosphere; Stage #2: tert-butyldimethylsilyl chloride In tetrahydrofuran at -78 - 20℃; for 2.25h; Inert atmosphere;	100%

: 121-97-1
4-Methoxypropiophenone

: 149-73-5
trimethyl orthoformate

: 50415-73-1
methyl 2-(4-methoxyphenyl)propionate

Conditions

Conditions	Yield
With sulfuric acid; 3-[4-(diacetoxyiodo)phenoxy]-1-propyl-N,N,N-trimethylammonium 4-methylbenzenesulfonate at 60℃; for 3h; Inert atmosphere;	99%
With [bis(acetoxy)iodo]benzene; hydrogen cation at 60℃; for 3h; oxidative rearrangement;	93%
With sulfuric acid; 1-(diacetoxyiodo)-4-methylbenzene at 60℃; for 3h;	92%

: 110-91-8
morpholine

: 711-33-1
4-trifluoromethyl propiophenone

: 121-97-1
4-Methoxypropiophenone

A: 71035-25-1
(E)-1-(4-methoxyphenyl)-3-morpholinoprop-2-en-1-one

B: 1177023-45-8
(E)-3-morpholino-1-[4-(trifluoromethyl)phenyl]prop-2-en-1-one

Conditions

Conditions	Yield
With bis(1,5-cyclooctadiene)nickel (0); potassium phosphate; chlorobenzene; trimethylphosphane In tetrahydrofuran; 1,4-dioxane at 100℃; for 40h; Inert atmosphere;	A 67% B 99%

...Expand

: 104-88-1
4-chlorobenzaldehyde

: 121-97-1
4-Methoxypropiophenone

: 3-(4-chlorophenyl)-3-hydroxy-1-(4-methoxyphenyl)-2-methylpropan-1-one

Conditions

Conditions	Yield
Stage #1: 4-chlorobenzaldehyde; 4-Methoxypropiophenone With titanium tetrachloride In dichloromethane at 0 - 20℃; Inert atmosphere; Stage #2: With triethylamine In dichloromethane at 0℃; Inert atmosphere;	99%

: 2564-83-2
2,2,6,6-tetramethyl-piperidine-N-oxyl

: 121-97-1
4-Methoxypropiophenone

: 1394206-50-8
1-(4-methoxyphenyl)-2-((2,2,6,6-tetramethylpiperidin-1-yl)oxy)propan-1-one

Conditions

Conditions	Yield
With 2,6-di-tert-butyl-pyridine; 2-chloro-1,3,2-benzodioxaborole In dichloromethane at 0 - 20℃; for 3h;	99%

: 133745-75-2
N-fluorobis(benzenesulfon)imide

: 121-97-1
4-Methoxypropiophenone

: 1453101-04-6
N-(2-methoxy-5-propionylphenyl)-N-(phenylsulfonyl)benzenesulfonamide

Conditions

Conditions	Yield
With [Ag(2,2'-bipyridine)2](ClO4); C20H28N4O2Pd*2CHF3O3S In acetonitrile at 23℃; for 24h; Inert atmosphere; Sealed tube;	99%
With [Ag(2,2'-bipyridine)2](ClO4); C20H28N4O2Pd(2+)*2CF3O3S(1-) In acetonitrile at 23℃; for 24h; Inert atmosphere; Sealed tube;	99%

: 670-54-2
ethenetetracarbonitrile

: 121-97-1
4-Methoxypropiophenone

: 1060799-27-0
2-chloro-6-(4-methoxyphenyl)-5-methylpyridine-3,4-dicarbonitrile

Conditions

Conditions	Yield
With oxalyl dichloride In methanol at 40℃; for 0.133333h; Sonication;	99%

: 121-97-1
4-Methoxypropiophenone

: 5349-60-0
1-(4-methoxyphenyl)-1-propanol

Conditions

Conditions	Yield
With sodium tetrahydroborate In isopropyl alcohol at 20℃; for 26h;	98.7%
With N,N,N,N,-tetramethylethylenediamine; diethoxymethylane; iron(II) acetate at 65℃; for 24h;	91%
With ethanol; sodium

: 7677-24-9
trimethylsilyl cyanide

: 121-97-1
4-Methoxypropiophenone

: 2-(4-Methoxy-phenyl)-2-trimethylsilanyloxy-butyronitrile

Conditions

Conditions	Yield
With tin ion-exchanged montmorillonite In dichloromethane at 20℃; for 0.0833333h; Inert atmosphere;	98%
With zinc(II) iodide for 36h; Ambient temperature;

: 127-19-5
N,N-dimethyl acetamide

: 121-97-1
4-Methoxypropiophenone

: 200353-84-0
1-(4-methoxyphenyl)-1-oxopropan-2-yl acetate

Conditions

Conditions	Yield
Stage #1: N,N-dimethyl acetamide; 4-Methoxypropiophenone With trifluorormethanesulfonic acid; thallium(III) acetate at 60℃; for 0.333333h; Stage #2: With water for 0.166667h; Further stages.;	98%

: 67-56-1
methanol

: 121-97-1
4-Methoxypropiophenone

: 50415-73-1
methyl 2-(4-methoxyphenyl)propionate

Conditions

Conditions	Yield
With sulfuric acid; trimethyl orthoformate for 0.333333h; Heating;	98%

: 726-42-1
di-p-tolylcarbodiimide

: 121-97-1
4-Methoxypropiophenone

: 39192-94-4
N-(p-methylphenyl)-p-methoxybenzamide

Conditions

Conditions	Yield
With dimanganese decacarbonyl In 1,4-dioxane at 150℃; for 24h; Sealed tube; Inert atmosphere;	98%

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: 121-97-1
4-Methoxypropiophenone

: 172688-06-1
1-p-anisyl-2-(formyloxy)-propan-1-one

Conditions

Conditions	Yield
Stage #1: N,N-dimethyl-formamide; 4-Methoxypropiophenone With trifluorormethanesulfonic acid; thallium(III) acetate at 60℃; for 0.333333h; Stage #2: With water for 0.166667h; Further stages.;	97%

: 106-43-4
para-chlorotoluene

: 121-97-1
4-Methoxypropiophenone

: 1-(4-methoxyphenyl)-2-(4-methylphenyl)-propan-1-one

Conditions

Conditions	Yield
With C40H44ClN3Pd; sodium t-butanolate In toluene at 80℃; for 3h; Inert atmosphere;	97%
With diaminochlorophosphine ligand; sodium t-butanolate; [Pd(dibenzylideneacetone)2] In toluene at 105℃; for 24h;	90%
With PdCl2(C3H3N2(CH3))(C3H2N2(C6H3(C3H7)2)2); potassium tert-butylate In toluene at 80℃; for 6h; Inert atmosphere;	80%

: 100-58-3
phenylmagnesium bromide

: 121-97-1
4-Methoxypropiophenone

: 19810-20-9
4-methoxy-α-phenyl-β-methylstyrene

Conditions

Conditions	Yield
Stage #1: 4-Methoxypropiophenone With aluminium(III) triflate In dichloromethane at -30℃; for 0.5h; Inert atmosphere; Stage #2: phenylmagnesium bromide In diethyl ether; dichloromethane at -30 - 20℃; for 24h; Inert atmosphere;	97%

: 95-49-8
2-methylchlorobenzene

: 121-97-1
4-Methoxypropiophenone

: 1-(4-methoxyphenyl)-2-(o-tolyl)propan-1-one

Conditions

Conditions	Yield
With C41H50ClN3Pd; sodium t-butanolate In 1,4-dioxane at 100℃; for 4h;	97%

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 121-97-1
4-Methoxypropiophenone

: 1-(4-methoxyphenyl)-2-methyl-3-(dimethylamino)prop-2-enone

Conditions

Conditions	Yield
In N,N-dimethyl-formamide Condensation; Heating;	96%

Methoxypropiophenone Chemical Properties

IUPAC Name: 1-(4-Methoxyphenyl)propan-1-one
Systematic of 1-Propanone,1-(4-methoxyphenyl)- (CAS NO.121-97-1): 4'-Methoxypropiophenone ; AI3-04094 ; EINECS 204-512-7 ; Ethyl 4-methoxyphenyl ketone ; NSC 11834 ; p-Methoxypropiophenone ; Propiophenone, 4'-methoxy- (8CI)
CAS NO: 121-97-1
Molecular Formula of 1-Propanone,1-(4-methoxyphenyl)- (CAS NO.121-97-1): C₁₀H₁₂O₂
Molecular Weight: 164.2011
Molecular Structure:

Melting Point: 27-29 °C
H bond acceptors: 2
Freely Rotating Bonds: 3
Polar Surface Area: 26.3 Å²
Index of Refraction: 1.501
Molar Refractivity: 47.59 cm³
Molar Volume: 161.4 cm³
Surface Tension: 33.6 dyne/cm
Density of 1-Propanone,1-(4-methoxyphenyl)- (CAS NO.121-97-1): 1.016 g/cm³
Flash Point: 118.8 °C
Enthalpy of Vaporization: 51.06 kJ/mol
Boiling Point: 272.3 °C at 760 mmHg
Vapour Pressure: 0.00612 mmHg at 25°C

Methoxypropiophenone Safety Profile

Hazard Codes: Xi
Safety Statements: 24/25
S24/25: Avoid contact with skin and eyes.
RIDADR: 1993
WGK Germany: 3
Hazard Note: Irritant

Product Name

Methoxypropiophenone

Synthetic route

Methoxypropiophenone Chemical Properties

Methoxypropiophenone Safety Profile

Related Products

Hot Products