N-Aminomorpholine supplier | CasNO.4319-49-7

Name
N-Aminomorpholine
EINECS 224-347-4
CAS No. 4319-49-7
Article Data33
CAS DataBase
Density 1.062 g/cm³
Solubility Miscible with water
Melting Point
Formula C₄H₁₀N₂O
Boiling Point 168 °C at 760 mmHg
Molecular Weight 102.136
Flash Point 58.3 °C
Transport Information UN 1993 3/PG 3
Appearance Clear colorless to faintly yellow liquid
Safety 23-16
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Morpholine,4-amino- (6CI,7CI,8CI);(Morpholin-4-yl)amine;4-Aminomorpholine;4-Morpholineamine;N-Aminomorpholine;NSC 6825;
PSA 38.49000
LogP -0.16950

Synthetic route

: 59-89-2
N-nitrosomorpholine

: 4319-49-7
1-aminomorpholine

Conditions

Conditions	Yield
With titanium(III) chloride In water for 1h; Ambient temperature;	76%
With ethanol; sodium
With zinc In acetic acid

: 59-89-2
N-nitrosomorpholine

A: 4319-49-7
1-aminomorpholine

B: 57902-11-1
N,N'-bis(morpholino)diazene

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In diethyl ether at 0 - 10℃; for 3h; 1) R.T., 1 h 2) reflux, 3 h;	A 31% B 1.0 g
With lithium aluminium tetrahydride In diethyl ether at 0 - 10℃; for 3h; 1) R.T., 1 h 2) reflux, 3 h;	A 31% B 31%

: 110-91-8
morpholine

: 4319-49-7
1-aminomorpholine

Conditions

Conditions	Yield
With chloroamine
With potassium hydroxide; hydroxylamine-O-sulfonic acid In water for 0.166667h; Heating;
With ammonium acetate; hydrogenchloride; sodium nitrite In methanol; water

: 13529-51-6
N,N-di(2-hydroxyethyl)hydrazine

A: 110-91-8
morpholine

B: 4319-49-7
1-aminomorpholine

Conditions

Conditions	Yield
With sulfuric acid

: 111-44-4
3-oxa-1,5-dichloropentane

: 4319-49-7
1-aminomorpholine

Conditions

Conditions	Yield
With ethanol; hydrazine hydrate

: 59-89-2
N-nitrosomorpholine

A: 110-91-8
morpholine

B: 4319-49-7
1-aminomorpholine

Conditions

Conditions	Yield
With titanium(III) chloride; ammonium acetate In water for 1h; Product distribution; Ambient temperature; variation of reaction conditions ( pH<1, pH=9.4 );	A 3 % Chromat. B 86 % Chromat.
With hydrogenchloride; zinc In water for 24h; Product distribution; Ambient temperature;	A 8 % Chromat. B 98 % Chromat.
With potassium hydroxide; aluminium In water for 24h; Product distribution; Ambient temperature;	A 43 % Chromat. B 64 % Chromat.

: 4164-32-3
N-nitromorpholine

A: 110-91-8
morpholine

B: 4319-49-7
1-aminomorpholine

Conditions

Conditions	Yield
With acetic acid In acetonitrile Product distribution; Mechanism;

: 59-89-2
N-nitrosomorpholine

A: 4319-49-7
1-aminomorpholine

B dimorpholino-diimide: dimorpholino-diimide

Conditions

Conditions	Yield
With acetic acid; zinc

: 59-89-2
N-nitrosomorpholine

: 64-19-7
acetic acid

zinc dust: zinc dust

A: 4319-49-7
1-aminomorpholine

B dimorpholino-diimide: dimorpholino-diimide

...Expand

: 64-17-5
ethanol

: 7803-57-8
hydrazine hydrate

: 111-44-4
3-oxa-1,5-dichloropentane

: 4319-49-7
1-aminomorpholine

...Expand

: 7732-18-5
water

: 7803-57-8
hydrazine hydrate

: 111-44-4
3-oxa-1,5-dichloropentane

A: 4319-49-7
1-aminomorpholine

B: 17173-82-9
4,4'-bimorpholine

C: bis-(2-morpholinoamino-ethyl)-ether

...Expand

: Ni(H2NC6H4SO2NC3H2NS)2(4-amino-morpholine)2

A: 4319-49-7
1-aminomorpholine

B: sulfanilic acid thiazol-2-ylamide; nickel (II)-salt

Conditions

Conditions	Yield
With H2O or aq. mineral acid decompn. with H2O or dild. aq. mineral acid;
decompn. on heating;
decompn. on heating;
With H2O or aq. mineral acid decompn. with H2O or dild. aq. mineral acid;

: 21223-18-7
O(CH2CH2)2NNH2*BH3

: 7732-18-5
water

A: 4319-49-7
1-aminomorpholine

B: 1333-74-0
hydrogen

C: 11113-50-1
boric acid

Conditions

Conditions	Yield
In water
In water

...Expand

: 4319-49-7
1-aminomorpholine

: 98-59-9
p-toluenesulfonyl chloride

: 351186-41-9
4-methyl-N-morpholin-4-ylbenzenesulfonamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 4℃;	100%
In tetrahydrofuran at 20℃; for 3h; Inert atmosphere;	17 mg

: 4319-49-7
1-aminomorpholine

: 1240998-70-2
1-(2,4-dichlorophenyl)-6-methyl-1H-benzofuro[3,2-0c]pyrazole-3-carboxylic acid

: 1240996-83-1
N-(morpholin-1-yl)-1-(2,4-dichlorophenyl)-6-methyl-1H-benzofuro[3,2-c]pyrazole-3-carbohydrazide

Conditions

Conditions	Yield
Stage #1: 1-(2,4-dichlorophenyl)-6-methyl-1H-benzofuro[3,2-0c]pyrazole-3-carboxylic acid With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In dichloromethane at 20℃; for 1h; Stage #2: 1-aminomorpholine In dichloromethane at 20℃; for 22h;	100%

: 4319-49-7
1-aminomorpholine

: 50-00-0
formaldehyd

: 7-[4-(4-{[(4-benzyl-5-mercapto-4H-1,2,4-triazole-3-yl)methyl]amino}-2-fluorophenyl)piperazin-1-yl]-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinolin-3-carboxylic acid

: 7-(4-{4-[({4-benzyl-1-[(morpholin-4-ylamino)methyl]-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl}methyl)amino]-2-fluorophenyl}piperazin-1-yl)-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 120℃; for 0.1h; Temperature; Reagent/catalyst; Solvent; Mannich Aminomethylation; Microwave irradiation;	100%

...Expand

: 4319-49-7
1-aminomorpholine

: 23074-10-4
5-ethylfurfural

: 125142-80-5
[1-(5-Ethyl-furan-2-yl)-meth-(E)-ylidene]-morpholin-4-yl-amine

Conditions

Conditions	Yield
In ethanol for 0.5h; heating on a steam bath;	99%

: 4319-49-7
1-aminomorpholine

: 5720-07-0
4-methoxyphenylboronic acid

: 557780-43-5
4-methoxy-N-morpholinobenzenesulfonamide

Conditions

Conditions	Yield
With DABCO-bis(sulfur dioxide); tetrabutylammomium bromide; oxygen; palladium diacetate In 1,4-dioxane at 80℃; for 12h;	99%

: 4319-49-7
1-aminomorpholine

: 2553-19-7
diethoxydiphenylsilane

: 351186-42-0
N‐morpholinobenzenesulfonamide

Conditions

Conditions	Yield
With 1,4-diazabicyclo[2.2.2]octane-triethylenediamine-bis(sulfur dioxide); oxygen; copper diacetate; cesium fluoride; XPhos In 1,4-dioxane at 80℃;	99%

: 4319-49-7
1-aminomorpholine

: C9H8ClN2O(1+)*BF4(1-)

: 1-(6-chloro-2,3-dihydrobenzofuran-3-yl)-N-morpholinomethanesulfonamide

Conditions

Conditions	Yield
With 1,4-diazabicyclo[2.2.2]octane-triethylenediamine-bis(sulfur dioxide) In acetonitrile at 25℃; for 0.166667h; Inert atmosphere;	99%

: 4319-49-7
1-aminomorpholine

: 52178-50-4
Methyl 3-formylbenzoate

: (E)-methyl 3-((morpholinoimino)methyl)benzoate

Conditions

Conditions	Yield
With magnesium sulfate In dichloromethane at 20℃; for 22h; Inert atmosphere;	99%
With magnesium sulfate In dichloromethane at 20℃; Inert atmosphere;

: 4319-49-7
1-aminomorpholine

: 529-20-4
2-methylphenyl aldehyde

: (E)-N-(2-methylbenzylidene)morpholin-4-amine

Conditions

Conditions	Yield
With magnesium sulfate In dichloromethane at 20℃; for 24h; Inert atmosphere;	99%
With magnesium sulfate In dichloromethane at 20℃; Inert atmosphere; Schlenk technique;	94%
With magnesium sulfate In dichloromethane at 20℃; Inert atmosphere;

: 4319-49-7
1-aminomorpholine

: 455-19-6
4-Trifluoromethylbenzaldehyde

: (E)-N-morpholino-1-(4-(trifluoromethyl)phenyl)methanimine

Conditions

Conditions	Yield
With magnesium sulfate In dichloromethane at 20℃; for 18h; Inert atmosphere;	99%
With magnesium sulfate In dichloromethane at 20℃; Inert atmosphere; Schlenk technique;	92%
With magnesium sulfate In dichloromethane at 20℃; Inert atmosphere;	92%
With magnesium sulfate In dichloromethane at 20℃; Inert atmosphere;

: 4319-49-7
1-aminomorpholine

: 50-00-0
formaldehyd

: 1-ethyl-6-fluoro-4-oxo-7-{4-[(5-oxo-4-phenyl-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl] piperazin-1-yl}-1,4-dihydroquinoline-3-carboxylic acid

: 1-ethyl-6-fluoro-7-{4-{[1-[(morpholin-4-ylamino)methyl]-5-oxo-4-phenyl-4,5-dihydro-1H-1,2,4-triazol-3-yl]methyl}piperazin-1-yl}-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Conditions

Conditions	Yield
With hydrogenchloride for 0.116667h; Time; Microwave irradiation;	99%

...Expand

: 4319-49-7
1-aminomorpholine

: 446-52-6
2-Fluorobenzaldehyde

: (E)-1-(2-fluorophenyl)-N-morpholinomethanimine

Conditions

Conditions	Yield
With magnesium sulfate In dichloromethane at 20℃; for 16h; Inert atmosphere;	99%

: 4319-49-7
1-aminomorpholine

: 87-13-8
diethyl 2-ethoxymethylenemalonate

: 94621-02-0
(morpholinyl-4 amino)-3 ethoxycarbonyl-2 propenoate d'ethyle

Conditions

Conditions	Yield
In methanol for 1h; Ambient temperature;	98%

: 796875-26-8
1-(4-chlorophenyl)-2-(2,4-dichlorophenyl)-5-methyl-1H-imidazole-4-carboxylic acid

: 4319-49-7
1-aminomorpholine

: 1-(4-Chlorophenyl)-2-(2,4-dichlorophenyl)-5-methyl-N-(morpholin-4-yl)-1H-imidazole-4-carboxamide

Conditions

Conditions	Yield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 16h;	98%

: 4319-49-7
1-aminomorpholine

: 16419-60-6
2-Methylphenylboronic acid

: 1255365-30-0
2-methyl-N-morpholinobenzenesulfonamide

Conditions

Conditions	Yield
With DABCO-bis(sulfur dioxide); tetrabutylammomium bromide; oxygen; palladium diacetate In 1,4-dioxane at 80℃; for 12h;	98%

: 4319-49-7
1-aminomorpholine

: 98-80-6
phenylboronic acid

: 351186-42-0
N‐morpholinobenzenesulfonamide

Conditions

Conditions	Yield
With DABCO-bis(sulfur dioxide); tetrabutylammomium bromide; oxygen; palladium diacetate In 1,4-dioxane at 80℃; for 12h;	98%

: 4319-49-7
1-aminomorpholine

: 36719-51-4
3,3-diethyl-1-(4-methylphenyl)-1-triazene

: 351186-41-9
4-methyl-N-morpholin-4-ylbenzenesulfonamide

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate; sulfur dioxide In acetonitrile at 60℃; for 3h; Inert atmosphere; Schlenk technique;	98%

: 4319-49-7
1-aminomorpholine

: 459-57-4
4-fluorobenzaldehyde

: (E)-1-(4-fluorophenyl)-N-morpholinomethanimine

Conditions

Conditions	Yield
With magnesium sulfate In dichloromethane at 20℃; Inert atmosphere; Schlenk technique;	98%
With magnesium sulfate In dichloromethane at 20℃; Inert atmosphere;	93%
With magnesium sulfate In dichloromethane at 20℃; Inert atmosphere;

: 4319-49-7
1-aminomorpholine

: 105-07-7
4-cyanobenzaldehyde

: (E)-4-((morpholinoimino)methyl)benzonitrile

Conditions

Conditions	Yield
With magnesium sulfate In dichloromethane at 20℃; for 20h; Inert atmosphere;	98%
With magnesium sulfate In dichloromethane at 20℃; Inert atmosphere; Schlenk technique;	83%
With magnesium sulfate In dichloromethane at 20℃;

: 4319-49-7
1-aminomorpholine

: 75-15-0
carbon disulfide

: 107-05-1
3-chloroprop-1-ene

: 2-(morpholine-4-yl)imino-4-(iodomethyl)-1,3-dithiolane

Conditions

Conditions	Yield
Stage #1: 1-aminomorpholine; carbon disulfide; 3-chloroprop-1-ene With potassium carbonate In neat liquid at 0 - 20℃; Green chemistry; Stage #2: With iodine In neat liquid at 20℃; for 0.3h; Green chemistry;	98%

...Expand

N-Aminomorpholine Chemical Properties

IUPAC Name: Morpholin-4-amine
Molecular Formula: C₄H₁₀N₂O
Molecular Weight: 102.14 g/mol
Canonical SMILES: N1(CCOCC1)N
InChI: InChI=1/C4H10N2O/c5-6-1-3-7-4-2-6/h1-5H2
Mol File: 4319-49-7.mol
EINECS: 224-347-4
Classification Code: Mutation data
Product Categories: Variousamine; Aromatic Morpholines; Amines;Morpholines & Thiomorpholines; Morpholines & Thiomorpholines; Building Blocks; Heterocyclic Building Blocks; Morpholines
Water Solubility: miscible
logP(octanol-water): -1.580
XLogP3: -1.1
H-Bond Donor: 1
H-Bond Acceptor: 3
Rotatable Bond Count: 0
Exact Mass: 102.079313
MonoIsotopic Mass: 102.079313
Topological Polar Surface Area: 38.5
Heavy Atom Count: 7
Complexity: 51.7
Index of Refraction: 1.477
Molar Refractivity: 27.17 cm³
Molar Volume: 96.1 cm³
Polarizability: 10.77×10^-24cm³
Surface Tension: 36.9 dyne/cm
Density: 1.062 g/cm³
Flash Point: 58.3 °C
Enthalpy of Vaporization: 40.44 kJ/mol
Boiling Point: 168 °C at 760 mmHg
Atmospheric OH Rate Constant: 7.48E-11 cm³/molecule-sec at 25 °C
Vapour Pressure of 4-Morpholinamine (CAS NO.4319-49-7): 1.65 mmHg at 25 °C

N-Aminomorpholine Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	oral	> 1gm/kg (1000mg/kg)		Farmaco. Vol. 45, Pg. 223, 1990.

N-Aminomorpholine Safety Profile

Hazard Codes: Harmful Xn. Flammable F. Irritant Xi
Risk Statements: 20/21/22-36/37/38
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed.
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36-23-16
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36: Wear suitable protective clothing.
S23: Do not breathe vapour.
S16: Keep away from sources of ignition.
RIDADR: UN 1993 3/PG 3
WGK Germany: 3
Hazard Note: Harmful
HazardClass: 3
PackingGroup of 4-Morpholinamine (CAS NO.4319-49-7): III

N-Aminomorpholine Specification

4-Morpholinamine (CAS NO.4319-49-7), its Synonyms are Morpholin-4-ylamine ; Morpholine, 4-amino- ; 4-27-00-00623 (Beilstein Handbook Reference) ; 4-Aminomorpholine ; Morpholine, 4-amino- ; N-Aminomorpholine . It is clear colorless to faintly yellow liquid.

Product Name

N-Aminomorpholine

Synthetic route

N-Aminomorpholine Chemical Properties

N-Aminomorpholine Toxicity Data With Reference

N-Aminomorpholine Safety Profile

N-Aminomorpholine Specification

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