N-Methylphenethylamine supplier

Name
N-METHYLPHENETHYLAMINE
EINECS 209-632-3
CAS No. 589-08-2
Article Data87
CAS DataBase
Density 0.93 g/mL at 25 °C(lit.)
Solubility
Melting Point 0.93oC
Formula C₉H₁₃N
Boiling Point 201.739 °C at 760 mmHg
Molecular Weight 135.209
Flash Point 73.889 °C
Transport Information UN 2735 8/PG 3
Appearance clear colorless to light yellow liquid
Safety 26-36/37/39-45-61-39
Risk Codes 34-42/43-52/53-41-22
Molecular Structure
Hazard Symbols C,Xn
Synonyms Phenethylamine,N-methyl- (8CI);(2-(Methylamino)ethyl)benzene;(2-Phenylethyl)methylamine;N-(Phenylethyl)methylamine;N-Methyl-2-phenylethanamine;N-Methyl-N-(2-phenylethyl)amine;N-Methyl-b-phenethylamine;N-Methyl-b-phenylethylamine;N-Methylbenzeneethanamine;N-Methylphenethylamine;N-Phenethylmethylamine;
PSA 12.03000
LogP 1.83940

Synthetic route

: 109-73-9
N-butylamine

: 3-methyl-2-(N-methylphenethylamino)benzothiazolium toluene-p-sulphonate

A: 70038-63-0
butyl-(3-methyl-3H-benzothiazol-2-ylidene)-amine

B: 589-08-2
N-Methyl-N-phenethylamine

Conditions

Conditions	Yield
In dichloromethane at 25℃; for 3h;	A 95% B 85%

...Expand

: 25566-59-0
N-methyl-N-(2-phenethyl)-4-methylbenzenesulfonamide

: 589-08-2
N-Methyl-N-phenethylamine

Conditions

Conditions	Yield
With sodium tetrahydroborate; methoxybenzene In ethanol Irradiation; other reducing agent;	91%
With sodium tetrahydroborate; methoxybenzene In ethanol for 1h; Product distribution; Quantum yield; Irradiation; other solvents, reagents, reagents ratio;	91%
With sodium tetrahydroborate; methoxybenzene In ethanol Mechanism; Rate constant; Quantum yield; Irradiation; effect of other reducing agents, other electron donors, other solvent;	91%
With hydrogenchloride at 180℃; Hydrolysis;
With tetrabutylammonium perchlorate In N,N-dimethyl-formamide various p-tolylsulfonamides, investigation of the deprotection by cathodic cleveage;

: 20020-27-3
2-phenylethyl mesylate

: 74-89-5
methylamine

: 589-08-2
N-Methyl-N-phenethylamine

Conditions

Conditions	Yield
Stage #1: 2-phenylethyl mesylate; methylamine In methanol; water at 140℃; under 15514.9 Torr; for 0.166667h; Flow reactor; Stage #2: With potassium hydroxide In water Solvent;	90%

: 25566-59-0
N-methyl-N-(2-phenethyl)-4-methylbenzenesulfonamide

A: 536-57-2
p-toluene sulfinic acid

B: 1858-86-2, 59153-38-7, 59203-02-0, 112458-71-6
Ethyl p-toluenesulfinate

C: 672-78-6
methyl p-toluene sulfinate

D: 589-08-2
N-Methyl-N-phenethylamine

Conditions

Conditions	Yield
With sodium tetrahydroborate; 1,5-dimethoxynaphthalene In ethanol Irradiation;	A 71% B n/a C n/a D 89%

...Expand

: 122-78-1
phenylacetaldehyde

: 74-89-5
methylamine

: 589-08-2
N-Methyl-N-phenethylamine

Conditions

Conditions	Yield
Stage #1: phenylacetaldehyde; methylamine With titanium(IV) isopropylate In methanol at 20℃; for 5h; Stage #2: With sodium tetrahydroborate In methanol at 20℃; for 2h;	88%
With alkali durch Reduktion des Kondensationsprodukts mit Natrium und Alkohol;
With formic acid; N-terminal His6-tagged formate dehydrogenase from Candida boidinii; Rs-amine dehydrogenase (originating from the enzyme engineeringof phenylalanine dehydrogenases from Rhodococcus sp. M4); NAD In aq. buffer at 30℃; for 48h; pH=8.5; Enzymatic reaction;

: 2-oxo-2-phenylethyl methyl(phenethyl)carbamate

: 589-08-2
N-Methyl-N-phenethylamine

Conditions

Conditions	Yield
With potassium phosphate; tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate; ascorbic acid In water; acetonitrile at 20℃; for 16h; Sealed tube; Irradiation; Inert atmosphere;	87%

: 6830-82-6
N-methylphenylacetamide

: 589-08-2
N-Methyl-N-phenethylamine

Conditions

Conditions	Yield
With sodium tetrahydroborate; bromine In 1,2-dimethoxyethane at -10 - 20℃; for 48h;	82%
With hydrogenchloride; arsenic(III) trioxide at 35 - 40℃; Electrolysis.an Bleikathoden;
With antimony pentoxide; sulfuric acid Electrolysis.an Bleikathoden;

: 415929-57-6
N,N-dimethyl-4-((methyl(phenethyl)amino)methyl)aniline

: 589-08-2
N-Methyl-N-phenethylamine

Conditions

Conditions	Yield
With water; trifluoroacetic acid In acetonitrile at 120℃; for 5h; Sealed tube;	75%

: 67-56-1
methanol

: 6926-44-9
phenethyl azide

A: 589-08-2
N-Methyl-N-phenethylamine

B: 1126-71-2
N,N-dimethylphenethylamine

Conditions

Conditions	Yield
With trans-RuCl(phenpyra-Me)(PPh3)2PF6; sodium hydroxide at 125℃; for 36h; Sealed tube; Inert atmosphere; Glovebox;	A 10 %Chromat. B 75%

...Expand

: 78190-66-6
N-<1-Phenyl-2,2,2-trichlor-aethyl>-methylamin

: 589-08-2
N-Methyl-N-phenethylamine

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In diethyl ether for 10h; Heating;	71%

: 25566-59-0
N-methyl-N-(2-phenethyl)-4-methylbenzenesulfonamide

A: 80-40-0
ethyl ester of p-toluenesulfonic acid

B: 589-08-2
N-Methyl-N-phenethylamine

Conditions

Conditions	Yield
With 1,5-dimethoxynaphthalene; sodium ethanolate In ethanol Irradiation;	A 45% B 62%

: 67-56-1
methanol

: 6926-44-9
phenethyl azide

A: 64-04-0
phenethylamine

B: 589-08-2
N-Methyl-N-phenethylamine

Conditions

Conditions	Yield
With trans-RuCl(phenpyra-Me)(PPh3)2PF6; sodium hydroxide at 125℃; for 5h; Sealed tube; Inert atmosphere; Glovebox;	A 10 %Chromat. B 60%

...Expand

: 1072-44-2
N-methylaziridine

(Ph)2CuLi: (Ph)2CuLi

: 589-08-2
N-Methyl-N-phenethylamine

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate In tetrahydrofuran	56%

: 383865-57-4
4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl-amine

A: 3-(4-Methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-1-methyl-1-phenethyl-urea

B: 589-08-2
N-Methyl-N-phenethylamine

Conditions

Conditions	Yield
	A 53% B n/a

: 23069-99-0
N-(2-phenylethyl)formamide

: 589-08-2
N-Methyl-N-phenethylamine

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In tetrahydrofuran Reflux;	34%
With lithium aluminium tetrahydride; diethyl ether
Multi-step reaction with 2 steps 1: potassium; toluene 2: concentrated hydrochloric acid / Hydrolysis View Scheme

: 3240-93-5
piperonal-phenethylimine

: 74-88-4
methyl iodide

: 589-08-2
N-Methyl-N-phenethylamine

Conditions

Conditions	Yield
at 20℃; Erwaermen des Reaktionsprodukts mit Wasser;

: 16766-83-9
2-(2-phenylethyl)-1,2-benzisothiazol-3(2H)-one 1,1-dioxide

: 589-08-2
N-Methyl-N-phenethylamine

Conditions

Conditions	Yield
ueber mehrere Stufen;

: 7738-38-7
2-(phenethylamino)acetic acid

: 589-08-2
N-Methyl-N-phenethylamine

Conditions

Conditions	Yield
beim Erhitzen ueber den Schmelzpunkt;
beim Erhitzen ueber den Schmelzpunkt;

: 27566-66-1
N-methyl-N-phenethylcyanamide

: 589-08-2
N-Methyl-N-phenethylamine

Conditions

Conditions	Yield
With hydrogenchloride at 160℃;
Multi-step reaction with 2 steps 1: aqueous alcoholic sulfuric acid 2: hydrochloric acid / 160 °C View Scheme

: 412274-51-2
N-(2-bromo-2-phenylethyl)-N,4-dimethylbenzenesulfonamide

: 589-08-2
N-Methyl-N-phenethylamine

Conditions

Conditions	Yield
With pentan-1-ol; sodium

: 77130-13-3
N-Methylthiophenylacetamide

: 589-08-2
N-Methyl-N-phenethylamine

Conditions

Conditions	Yield
With hydrogenchloride at 30 - 40℃; Electrolysis.an Bleikathoden;
With sodium tetrahydroborate; triethyloxonium fluoroborate 1.) CH2Cl2, 25 deg C, 10-20 min; 2.) anhydrous methanol 2-3 h; Yield given. Multistep reaction;

: 52516-20-8
2-(3-Chlorophenyl)-N-methylethan-1-amine

A: 824-21-5
N-methylindoline

B: 589-08-2
N-Methyl-N-phenethylamine

Conditions

Conditions	Yield
With diethyl ether; phenyllithium; diethylamine

: 90784-34-2
N-methyl-N-phenethylformamide

: 589-08-2
N-Methyl-N-phenethylamine

Conditions

Conditions	Yield
With hydrogenchloride Hydrolysis;
With hydrogenchloride; methanol for 18h; Heating;

: 73355-67-6
N-methyl-N-phenethyl-urea

: 589-08-2
N-Methyl-N-phenethylamine

Conditions

Conditions	Yield
With hydrogenchloride at 160℃;

: 84395-76-6
(E)-N-benzyl-N-methyl-2-phenylethen-1-amine

: 589-08-2
N-Methyl-N-phenethylamine

Conditions

Conditions	Yield
With palladium on activated charcoal; ethanol Hydrogenation;

: 622-24-2
2-phenylethyl chloride

: 74-89-5
methylamine

: 589-08-2
N-Methyl-N-phenethylamine

Conditions

Conditions	Yield
With ethanol at 100℃;
With benzene at 100℃;

: 3240-95-7
N-benzylidene-2-phenylethanamine

: 74-88-4
methyl iodide

: 589-08-2
N-Methyl-N-phenethylamine

Conditions

Conditions	Yield
nachfolgende Hydrolyse;
und Erwaermen des Reaktionsprodukts mit wasserhaltigem Aethanol;

: 52516-17-3
2-(2-chlorochlorophenyl)-N-methylethanamine

: 591-51-5
phenyllithium

A: 824-21-5
N-methylindoline

B: 589-08-2
N-Methyl-N-phenethylamine

...Expand

: 103-63-9
1-phenyl-2-bromoethane

: 74-89-5
methylamine

A: 13977-33-8
N-methyl-N-phenethyl-2-phenylethan-1-amine

B: 589-08-2
N-Methyl-N-phenethylamine

Conditions

Conditions	Yield
With ethanol
In ethanol at 0 - 20℃; for 40h; Overall yield = 90 percent; Overall yield = 1.4 g;

...Expand

: 50-00-0
formaldehyd

: 1589-82-8
phenylmagnesium bromide

: 74-89-5
methylamine

: 589-08-2
N-Methyl-N-phenethylamine

Conditions

Conditions	Yield
With diethyl ether

...Expand

: 598-21-0
2-Bromoacetyl bromide

: 589-08-2
N-Methyl-N-phenethylamine

: 73391-97-6
N-methyl-N-2-phenylethyl-2-bromoacetamide

Conditions

Conditions	Yield
In dichloromethane at -25 - 20℃;	100%
With potassium carbonate In dichloromethane at 0 - 20℃; for 3h;

: 147577-61-5
(2R)-2-(N-(tert-butoxycarbonyl)-N-methylamino)-3-(2-naphthyl)-propionic acid

: 589-08-2
N-Methyl-N-phenethylamine

: 202810-83-1
N-methyl-N-((1R)-1-(N-methyl-N-phenethylcarbamoyl)-2-(2-naphthyl)ethyl)carbamic acid tert-butyl ester

Conditions

Conditions	Yield
Stage #1: (2R)-2-(N-(tert-butoxycarbonyl)-N-methylamino)-3-(2-naphthyl)-propionic acid With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane; N,N-dimethyl-formamide at 0℃; for 0.333333h; Addition; Stage #2: N-Methyl-N-phenethylamine In dichloromethane; N,N-dimethyl-formamide at 0 - 20℃; for 16h; Condensation;	100%
With 1-hydroxy-7-aza-benzotriazole; N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride In dichloromethane; N,N-dimethyl-formamide at 0 - 20℃; for 16.3h;	1.89 g

: 589-08-2
N-Methyl-N-phenethylamine

: 742104-52-5
(5α,7α)-17-(cyclopropylmethyl)-4,5-epoxy-3,6-dimethoxy-6,14-ethenomorphinan-7-carboxyl chloride

: 214064-60-5
C34H40N2O4

Conditions

Conditions	Yield
With triethylamine In chloroform at 20℃;	100%

: 106-95-6
allyl bromide

: 589-08-2
N-Methyl-N-phenethylamine

: 37929-85-4
N-methyl-N-phenethylallylamine

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate; polymer-bound triphenylphosphine In tetrahydrofuran at 20℃; for 12h;	99%
Stage #1: N-Methyl-N-phenethylamine With (acryloyloxymethyl)polystyrene In N,N-dimethyl-formamide at 20℃; for 18h; Solid phase reaction; Michael addition; Stage #2: allyl bromide In N,N-dimethyl-formamide at 20℃; for 18h; Solid phase reaction; quaternization; Stage #3: With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 5h; Solid phase reaction; Hofmann elimination;	81%
With sodium hydrogencarbonate In N,N-dimethyl-formamide at 70℃; for 2h;	50%
Yield given. Multistep reaction;

: (1S,2S)-(+)-2-(methyl(phenethyl)amino)-1-phenylpropan-1-ol

: 589-08-2
N-Methyl-N-phenethylamine

: (1S,2S)-(+)-N,N'-dimethyl-N,N'-diphenethyl-1-phenylpropane-1,2-diamine

Conditions

Conditions	Yield
Stage #1: (1S,2S)-(+)-2-(methyl(phenethyl)amino)-1-phenylpropan-1-ol With methanesulfonyl chloride; triethylamine In diethyl ether at 0 - 20℃; Stage #2: With triethylamine In diethyl ether at 0 - 20℃; Stage #3: N-Methyl-N-phenethylamine In diethyl ether at 20℃; for 16h;	99%

: 506-68-3
bromocyane

: 589-08-2
N-Methyl-N-phenethylamine

: 27566-66-1
N-methyl-N-phenethylcyanamide

Conditions

Conditions	Yield
With sodium acetate In methanol at 20℃; Inert atmosphere; Schlenk technique;	99%

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: 589-08-2
N-Methyl-N-phenethylamine

: 90784-34-2
N-methyl-N-phenethylformamide

Conditions

Conditions	Yield
at 150℃; for 96h; Sealed tube; Inert atmosphere; Green chemistry;	99%
at 150℃; for 96h; Inert atmosphere; Sealed tube;	99%
With cobalt(II) acetate at 150℃; for 3h; Inert atmosphere; Sealed tube;	95%

: 589-08-2
N-Methyl-N-phenethylamine

: 170114-35-9
1-(2-Deoxy-β-D-erythro-pentofuranosyl)-4-(pentafluorophenyloxy)-2(1H)-pyrimidinone

: 1-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-4-(methyl-phenethyl-amino)-1H-pyrimidin-2-one

Conditions

Conditions	Yield
In 1,4-dioxane at 80℃;	98%

: 372-48-5
2-fluoropyridine

: 589-08-2
N-Methyl-N-phenethylamine

: N-methyl-N-phenethylpyridin-2-amine

Conditions

Conditions	Yield
With bis(1,5-cyclooctadiene)nickel (0); sodium t-butanolate; 1,3-bis[2,6-bis(1-methylethyl)phenyl]-1,3-dihydro-2H-imidazol-2-ylidene monohydrochloride In toluene at 100℃; for 20h; Inert atmosphere; Schlenk technique;	98%

: 10328-92-4
N-Methylisatoic anhydride

: 589-08-2
N-Methyl-N-phenethylamine

: N-Methyl-2-methylamino-N-phenethyl-benzamide

Conditions

Conditions	Yield
With isatoic anhydride resin In dichloromethane Ambient temperature; 1.) 14 h; 2.) 90 min;	97%

: 2130-96-3
O-benzyl-N-tert-butoxycarbonyl-L-tyrosine

: 589-08-2
N-Methyl-N-phenethylamine

: 173899-80-4
N-[Boc-(O-benzyl)-L-tyrosyl]-N-methyl-2-phenylethylamine

Conditions

Conditions	Yield
	97%

: 100-39-0
benzyl bromide

: 589-08-2
N-Methyl-N-phenethylamine

: 10479-24-0
N-(2-phenethyl)benzylmethylamine

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate; polymer-bound triphenylphosphine In tetrahydrofuran at 20℃; for 12h;	97%
Stage #1: N-Methyl-N-phenethylamine With REM resin at 20℃; for 2h; Stage #2: benzyl bromide In N,N-dimethyl-formamide for 18h; Stage #3: With N-ethyl-N,N-diisopropylamine In dichloromethane	95%
Stage #1: N-Methyl-N-phenethylamine With REM resin at 20℃; for 3h; Michael addition; Stage #2: benzyl bromide In N,N-dimethyl-formamide at 20℃; for 18h; Stage #3: With potassium carbonate; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 6h;

: 865538-79-0
phenyl 1H-indazol-5-ylcarbamate

: 589-08-2
N-Methyl-N-phenethylamine

: 1357473-65-4
3-(1H-indazol-5-yl)-1-methyl-1-phenethylurea

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran; N,N-dimethyl-formamide at 90℃; for 14h;	97%

: 6-chloro-N-phenylpyrimidine-4-carboxamide

: 589-08-2
N-Methyl-N-phenethylamine

: 6-(methyl(phenethyl)amino)-N-phenylpyrimidine-4-carboxamide

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In isopropyl alcohol at 100℃;	97%

: C5H10N2S*(x)HI

: 589-08-2
N-Methyl-N-phenethylamine

: N,1-dimethyl-N-phenethyl-4,5-dihydro-1H-imidazol-2-amine hydroiodide

Conditions

Conditions	Yield
at 70℃; for 2h;	97%

: 6485-79-6
chlorotriisopropylsilane

: 124-38-9
carbon dioxide

: 589-08-2
N-Methyl-N-phenethylamine

: N-Tsoc-methyl(2-phenylethyl)amine

Conditions

Conditions	Yield
With palladium 10% on activated carbon In N,N-dimethyl acetamide under 760.051 Torr; for 16h; Sealed tube; Heating; Schlenk technique;	96.2%

...Expand

: 12081-54-8
tetraethyldiborane(6)

: 589-08-2
N-Methyl-N-phenethylamine

: 22100-27-2
{methyl-(2-phenylethyl)amino}diethylborane

Conditions

Conditions	Yield
3 h at 70-100°C;	96%
3 h at 70-100°C;	96%

: 626-60-8
3-Chloropyridine

: 589-08-2
N-Methyl-N-phenethylamine

: 1445086-57-6
N-methyl-N-phenethylpyridin-3-amine

Conditions

Conditions	Yield
With C43H58ClO2PPd; sodium t-butanolate; ruphos In tetrahydrofuran at 85℃; for 6h; Inert atmosphere;	96%
With C30H43O2P*C13H13NO3PdS; sodium t-butanolate; ruphos In tetrahydrofuran at 85℃; for 24h;	80%
With methanesulfonato(2-dicyclohexylphosphino-2’,6’-di-i-propoxy-1,1’-biphenyl)(2’-methylamino-1,1‘-biphenyl-2-yl)palladium(II); sodium t-butanolate; ruphos In tetrahydrofuran at 85℃; for 24h; Inert atmosphere;	80%

: 56146-83-9
chlorosulfonyl-acetic acid methyl ester

: 589-08-2
N-Methyl-N-phenethylamine

: 233283-81-3
2-[methyl(phenethyl)sulfamoyl]acetic acid methyl ester

Conditions

Conditions	Yield
Stage #1: chlorosulfonyl-acetic acid methyl ester; N-Methyl-N-phenethylamine With triethylamine In tetrahydrofuran at 20℃; Stage #2: With hydrogenchloride In water pH=7;	96%

: 52805-48-8
2-(Benzyloxy)-1-naphthaldehyde

: 589-08-2
N-Methyl-N-phenethylamine

: N-((2-(benzyloxy)naphthalen-1-yl)methyl)-N-methyl-2-phenylethan-1-amine

Conditions

Conditions	Yield
With sodium tris(acetoxy)borohydride; acetic acid In 1,2-dichloro-ethane at 20℃; for 2.5h;	96%

: 60-35-5
acetamide

: 589-08-2
N-Methyl-N-phenethylamine

: 50893-11-3
N-methyl-N-phenyethylacetamide

Conditions

Conditions	Yield
With manganese(II) chloride tetrahydrate at 150℃; for 10h; Sealed tube; Microwave irradiation; Inert atmosphere;	96%
With cobalt(II) diacetate tetrahydrate at 150℃; for 3h; Sealed tube; Inert atmosphere;	83%

: 98-86-2
acetophenone

: 589-08-2
N-Methyl-N-phenethylamine

: C17H21N

Conditions

Conditions	Yield
With 1,4-diaza-bicyclo[2.2.2]octane; titanium(IV) isopropylate; hydrogen; iodine; triethylamine In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane at 20℃; under 30402 Torr; for 20h;	96%

: 536-74-3
phenylacetylene

: 589-08-2
N-Methyl-N-phenethylamine

: 220501-09-7
N-methyl-N-phenethyl-2-phenylacetamide

Conditions

Conditions	Yield
With potassium hexafluorophosphate; 4-methylpyridine-1-oxide; chloro(cyclopentadienyl)bis(triphenylphosphine)ruthenium (II) In 1,2-dichloro-ethane at 100℃; for 24h; Catalytic behavior; Reagent/catalyst; Solvent; Temperature; Inert atmosphere; Sealed tube;	96%

: 32387-21-6
1-methyl-3-indolecarboxylic acid

: 589-08-2
N-Methyl-N-phenethylamine

: 1-methyl-1H-indole-3-carboxylic acid N-methyl-N-phenethylamide

Conditions

Conditions	Yield
With PS-carbodiimide; benzotriazol-1-ol In 1-methyl-pyrrolidin-2-one at 100℃; for 0.0833333h; microwave irradiation;	95%

: 589-08-2
N-Methyl-N-phenethylamine

: 74-88-4
methyl iodide

: 1126-71-2
N,N-dimethylphenethylamine

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate; polymer-bound triphenylphosphine In tetrahydrofuran at 20℃; for 12h;	95%

: 589-08-2
N-Methyl-N-phenethylamine

: 183208-35-7
5-bromo-1H-pyrrolo[2,3-b]pyridine

: 1248587-68-9
N-methyl-N-phenethyl-1H-pyrrolo[2,3-b]pyridin-5-amine

Conditions

Conditions	Yield
With RuPhos palladacycle; lithium hexamethyldisilazane; ruphos In tetrahydrofuran at 65℃; for 4h; Inert atmosphere; Sealed vial;	95%

: 589-08-2
N-Methyl-N-phenethylamine

: 79-05-0
Propionamid

: 67191-48-4
N-methyl-N-phenethylpropionamide

Conditions

Conditions	Yield
With manganese(II) chloride tetrahydrate at 150℃; for 10h; Sealed tube; Microwave irradiation; Inert atmosphere;	95%
With cobalt(II) diacetate tetrahydrate at 150℃; for 3h; Sealed tube; Inert atmosphere;	46%

: 64596-35-6
phenyl (benzoyloxy)carbamate

: 589-08-2
N-Methyl-N-phenethylamine

: 3-(benzoyloxy)-1-methyl-1-phenethylurea

Conditions

Conditions	Yield
With 1H-imidazole In tetrahydrofuran at 100℃; for 2h; Microwave irradiation; Sealed tube;	95%

: 6601-22-5
2,6-Dichloro-4-morpholino-1,3,5-triazine

: 589-08-2
N-Methyl-N-phenethylamine

: 2-chloro-4-(methyl(phenethyl)amino)-6-morpholino-1,3,5-triazine

Conditions

Conditions	Yield
With potassium carbonate In acetone at 20℃; for 3h;	95%

N-Methylphenethylamine Specification

The Benzeneethanamine,N-methyl-, with the CAS registry number 589-08-2, is also known as N-Methyl-N-(2-phenylethyl)amine. It belongs to the product categories of Amines and Anilines; Phenyls & Phenyl-Het; Phenyls & Phenyl-Het. Its EINECS registry number is 209-632-3. This chemical's molecular formula is C₉H₁₃N and molecular weight is 135.21. What's more, both its IUPAC name and systematic name are the same which is called N-Methyl-2-phenylethanamine. It should be stored in a cool, dry and well-ventilated place. It is a chemical compound derived from phenethylamine. Its N-substitution results in less metabolism by monoamine oxidase than phenethylamine itself.

Physical properties about Benzeneethanamine,N-methyl- are: (1)ACD/LogP: 1.848; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -1.24; (4)ACD/LogD (pH 7.4): -0.87; (5)ACD/BCF (pH 5.5): 1.00; (6)ACD/BCF (pH 7.4): 1.00; (7)ACD/KOC (pH 5.5): 1.00; (8)ACD/KOC (pH 7.4): 1.00; (9)#H bond acceptors: 1; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 3 ; (12)Polar Surface Area: 12.03 Å²; (13)Index of Refraction: 1.509; (14)Molar Refractivity: 44.03 cm³; (15)Molar Volume: 147.574 cm³; (16)Polarizability: 17.455×10^-24cm³; (17)Surface Tension: 32.228 dyne/cm; (18)Density: 0.916 g/cm³; (19)Flash Point: 73.889 °C; (20)Enthalpy of Vaporization: 43.795 kJ/mol; (21)Boiling Point: 201.739 °C at 760 mmHg; (22)Vapour Pressure: 0.303 mmHg at 25 °C.

Preparation of Benzeneethanamine,N-methyl-: this chemical can be prepared by N-methyl-N-phenethyl-toluene-4-sulfonamide. This reaction needs reagent concentrated hydrochloric acid at temperature of 180 °C.

Benzeneethanamine,N-methyl- can be prepared by N-methyl-N-phenethyl-toluene-4-sulfonamide.

Uses of Benzeneethanamine,N-methyl-: it is used to produce other chemicals. For example, it can react with formaldehyde to get dimethyl-phenethyl-amine. The reaction occurs with reagent NaBH₄ and solvents tetrahydrofuran, trifluoroacetic acid at the temperature of 25 °C. The reaction time is 24 hours. The yield is 87 %.

Benzeneethanamine,N-methyl- can react with formaldehyde to get dimethyl-phenethyl-amine.

When you are dealing with this chemical, you should be very careful. This chemical is inflammation to the skin or other mucous membranes and may destroy living tissue on contacting. What's more, it may cause burns. Therefore, you should wear suitable protective clothing, gloves and eye/face protection. This material and its container must be disposed of as hazardous waste. In case of contacting with eyes, you should rinse immediately with plenty of water and seek medical advice. And in case of accident or if you feel unwell you should seek medical advice immediately.

You can still convert the following datas into molecular structure:
(1) SMILES: N(CCc1ccccc1)C
(2) InChI: InChI=1S/C9H13N/c1-10-8-7-9-5-3-2-4-6-9/h2-6,10H,7-8H2,1H3
(3) InChIKey: SASNBVQSOZSTPD-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Source
mouse	LD50	parenteral	180mg/kg (180mg/kg)	Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 195, Pg. 647, 1940.
mouse	LDLo	intraperitoneal	190mg/kg (190mg/kg)	Journal of Pharmacology and Experimental Therapeutics. Vol. 106, Pg. 341, 1952.
rat	LDLo	intraperitoneal	180mg/kg (180mg/kg)	Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 195, Pg. 647, 1940.
rat	LDLo	oral	1400mg/kg (1400mg/kg)	Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 195, Pg. 647, 1940.

Product Name

N-METHYLPHENETHYLAMINE

Synthetic route

N-Methylphenethylamine Specification

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