Triethylamine hydrochloride supplier

Name
Triethylamine hydrochloride
EINECS 209-067-2
CAS No. 554-68-7
Article Data337
CAS DataBase
Density 1.07 g/cm³
Solubility 1440 g/L (20 °C) in water
Melting Point 254-260 °C
Formula C₆H₁₆ClN
Boiling Point 90.5 °C at 760 mmHg
Molecular Weight 137.653
Flash Point 39 °C
Transport Information
Appearance White to off-white crystalline powder
Safety 26-36-36/37/39-22
Risk Codes 36/37/38-20/21/22
Molecular Structure
Hazard Symbols Xi, Xn
Synonyms Triethylammonium chloride;Triethylamine monohydrochloride;N,N-diethylethanamine hydrochloride;Ethanamine, N,N-diethyl-, hydrochloride;Amine, triethyl, hydrochloride;Triethylamine hydrochloribe;
PSA 3.24000
LogP 2.15010

Synthetic route

: 109431-87-0
(R)-tert-butyl 3-hydroxypyrrolidine-1-carboxylate

: 124-63-0
methanesulfonyl chloride

: 121-44-8
triethylamine

A: 554-68-7
triethylamine hydrochloride

B: 127423-61-4
tert-butyl (3R)-3-methylsulfonyloxypyrrolidine-1-carboxylate

Conditions

Conditions	Yield
In toluene at 3 - 14℃; Product distribution / selectivity;	A n/a B 100%

...Expand

: 121-44-8
triethylamine

: 554-68-7
triethylamine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In water for 1h; Cooling;	99%
With hydrogenchloride In water at 0℃; for 1h;	73%
With tetrachloromethane In benzene for 164h; Irradiation;	0.5%

: 7693-46-1
4-Nitrophenyl chloroformate

polyethylene glycol: polyethylene glycol

A PEG(NPC)2: PEG(NPC)2

B: 554-68-7
triethylamine hydrochloride

Conditions

Conditions	Yield
With triethylamine In acetonitrile at 80℃; for 8h; Heating / reflux;	A 99% B n/a

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: 2687-45-8
triethylamine N-oxide

: 97-00-7
1-chloro-2,4-dinitro-benzene

A: 51-28-5
2,4-Dinitrophenol

B: 554-68-7
triethylamine hydrochloride

Conditions

Conditions	Yield
In N,N-dimethyl-formamide for 24h;	A 98% B 98.5%
In N,N-dimethyl-formamide for 24h; Ambient temperature;	A 98% B 98.5%

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: 2,6-(C2H5)2C6H3NH2*BCl3

A: 2,6-xylidine

B: 5801-32-1
ClB{NHC6H3-2,6-(C2H5)2}2

C: 554-68-7
triethylamine hydrochloride

Conditions

Conditions	Yield
With triethylamine extn. with petroleum ether;	A n/a B 98% C n/a

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: 121-44-8
triethylamine

: 98-59-9
p-toluenesulfonyl chloride

: 927-74-2
1-butyn-4-ol

A: 23418-85-1
3-butyn-1-yl p-toluenesulfonate

B: 554-68-7
triethylamine hydrochloride

Conditions

Conditions	Yield
In dichloromethane at 0 - 20℃; for 21h;	A 97% B n/a

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: 96-45-7
N,N'-ethylenethiourea

: 554-68-7
triethylamine hydrochloride

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran	97%

: 41489-76-3
methyl-5-formyl-2-hydroxybenzoate

: 121-44-8
triethylamine

: 75-36-5
acetyl chloride

A: methyl 2-acetoxy-5-formylbenzoate

B: 554-68-7
triethylamine hydrochloride

Conditions

Conditions	Yield
Stage #1: methyl-5-formyl-2-hydroxybenzoate; triethylamine In tetrahydrofuran for 0.0333333h; Stage #2: acetyl chloride at 25℃; for 2h;	A 97% B n/a

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: 56-75-7
chloramphenicol

: 644-97-3
Dichlorophenylphosphine

: 554-68-7
triethylamine hydrochloride

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran	96%

: 933-18-6
B,B',B''-trichloroborazine

: 121-44-8
triethylamine

: 999-97-3
1,1,1,3,3,3-hexamethyl-disilazane

A: 113665-33-1
B,B',B''-tris{bis(trimethylsilyl)amino}borazine

B: 554-68-7
triethylamine hydrochloride

Conditions

Conditions	Yield
In benzene Addn. of mixt. of org. materials to a stirred soln. of B-compd. (C6H6) at room temp., stirring (room temp., 115 h).; Filtn. gives 96% of NEt3*HCl and 90% of borazine (obtained from filtrate). Purifn. by crystn. from hexane results in 71% pure material. Elem. anal.;	A 71% B 96%

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: 14794-31-1
ethyl 3-(chloroformyl)propionate

: 14691-88-4
4-amino-2,2,6,6-tetramethyl-1-piperidine-1-oxyl

A: 554-68-7
triethylamine hydrochloride

B: 82032-23-3
C15H27N2O4

Conditions

Conditions	Yield
With triethylamine In benzene 1.) 0 degC, 2.) R.T. 12 h;	A n/a B 95%

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: 794569-27-0
N,N-bis(trimethylsilyl)aminopropylmethyldichlorosilane

: 64-17-5
ethanol

A: N,N-(bis-trimethylsilyl)-3-aminopropylmethyldiethoxysilane

B: 554-68-7
triethylamine hydrochloride

Conditions

Conditions	Yield
With triethylamine In toluene at 20 - 30℃; for 3h;	A 95% B n/a

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: W(6+)*3Cl(1-)*CC(CH3)3(3-)*CH3OC2H4OCH3 = {Cl3(CH3OC2H4OCH3)WCC(CH3)3}

: 22693-41-0
2,4,6-Triisopropylthiophenol

A: 111975-83-8
{tungsten(C-t-Bu)(2,4,6-triisopropylbenzenethiolate)3Cl}{HNEt3}

B: 554-68-7
triethylamine hydrochloride

Conditions

Conditions	Yield
With triethylamine In dichloromethane byproducts: 1,2-dimethoxyethane; Slow addn. of solid W(C-t-Bu)Cl3(dme) to a stirred and cooled (-40°C) soln. of TIPTH and Et3N, soln. turns fisrt green, then red, warming (room temp.), stirring overnight.; Addn. of pentane, Et3NHCl pptd., filtn. through Celite, evapn. in vac. to dryness, elem. anal.;	A 95% B n/a

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: 527-69-5
2-furancarbonyl chloride

: 121-44-8
triethylamine

: 108-95-2
phenol

A: 2948-14-3
furan-2-carboxylic acid phenyl ester

B: 554-68-7
triethylamine hydrochloride

Conditions

Conditions	Yield
In tetrahydrofuran at 0℃; for 0.00416667h; Flow reactor; Green chemistry;	A 95% B n/a

...Expand

: 84115-18-4
ethyl α-chloro-α-nitro-β-hydroxypropionate

: 121-44-8
triethylamine

: 554-68-7
triethylamine hydrochloride

Conditions

Conditions	Yield
In ethanol; water at 29℃; for 0.3h; Product distribution;	94%

: 67-56-1
methanol

: 794569-27-0
N,N-bis(trimethylsilyl)aminopropylmethyldichlorosilane

A: bis(trimethylsilyl)aminopropylmethyldimethoxysilane

B: 554-68-7
triethylamine hydrochloride

Conditions

Conditions	Yield
With triethylamine In toluene at 20 - 30℃; for 3h;	A 94% B n/a

...Expand

: 1541-10-2
mesitylthiol

: W(6+)*3Cl(1-)*CC(CH3)3(3-)*CH3OC2H4OCH3 = {Cl3(CH3OC2H4OCH3)WCC(CH3)3}

A: 111997-40-1
{tungsten(C-t-Bu)(2,4,6-trimethylbenzenethiolate)3Cl}{HNEt3}

B: 554-68-7
triethylamine hydrochloride

Conditions

Conditions	Yield
With triethylamine In diethyl ether byproducts: 1,2-dimethoxyethane; Slow addn. of solid W(C-t-Bu)Cl3(dme) to a stirred and cooled (-30°C) soln. of TMTH and Et3N, soln. first turns green, then yellow, warming (room temp.), stirring (90 min).; Addn. of pentane, filtn. through Celite, evapn. to dryness in vac., elem. anal.;	A 94% B n/a

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: 67-56-1
methanol

: 794569-27-0
N,N-bis(trimethylsilyl)aminopropylmethyldichlorosilane

A: 3-[N,N-bis(trimethylsilyl)amino]propyldimethylmethoxysilane

B: 554-68-7
triethylamine hydrochloride

Conditions

Conditions	Yield
With triethylamine In toluene at 20 - 30℃; for 3h;	A 92% B n/a

...Expand

: 61085-25-4, 76181-72-1
N-cyano-N'-methyl-N"-(2-mercaptoethyl)-guanidine

: 78-94-4
methyl vinyl ketone

A: N-cyano-N'-methyl-N"-(2-(2-chloro-3-oxobutylthio)ethyl)guanidine

B: 554-68-7
triethylamine hydrochloride

Conditions

Conditions	Yield
With nitrogen; chlorine; triethylamine In chloroform	A 91% B n/a
With nitrogen; chlorine; triethylamine In chloroform	A 91% B n/a

...Expand

: 685-91-6
diethylacetamide

: 554-68-7
triethylamine hydrochloride

Conditions

Conditions	Yield
Stage #1: diethylacetamide With bis(cyclopentadienyl)dihydrozirconium; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane at 20℃; under 760.051 Torr; for 12h; Inert atmosphere; Stage #2: With hydrogenchloride In diethyl ether Inert atmosphere;	91%
Stage #1: diethylacetamide With [κ2-{Ph2P(Se)NC9H6N}Al(Me)2]; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane at 20℃; for 12h; Schlenk technique; Glovebox; Stage #2: With hydrogenchloride In water chemoselective reaction;	90%

: trans-4-isopropyl cyclohexylcarboxylic acid

: 13033-84-6
D-phenylalanine methyl ester hydrochloride

: N-(trans-4-isopropylcyclohexyl-1-carbonyl)-d-phenylalanine methyl ester

B: 554-68-7
triethylamine hydrochloride

Conditions

Conditions	Yield
Stage #1: trans-4-isopropylcyclohexanecarboxylic acid; triethylamine With pivaloyl chloride In acetone at 5 - 20℃; for 3.5h; Stage #2: D-phenylalanine methyl ester hydrochloride In acetone at 20℃; Product distribution / selectivity;	A 90.07% B n/a
Stage #1: trans-4-isopropylcyclohexanecarboxylic acid; triethylamine With chloroformic acid ethyl ester In acetone at 0 - 20℃; for 3.5h; Heating / reflux; Stage #2: D-phenylalanine methyl ester hydrochloride In acetone at 25℃; Product distribution / selectivity;	A 78.42% B n/a

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: 622-40-2
2-(morpholin-4-yl)ethanol

: 2942-59-8
2-chloronicotinic acid

A 2-chloronicotinic acid 1(2-morpholinoethyl)ester: 2-chloronicotinic acid 1(2-morpholinoethyl)ester

B: 554-68-7
triethylamine hydrochloride

Conditions

Conditions	Yield
With thionyl chloride; triethylamine In toluene	A 90% B n/a

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: 98-88-4
benzoyl chloride

: 121-44-8
triethylamine

: 108-95-2
phenol

A: 93-99-2
benzoic acid phenyl ester

B: 554-68-7
triethylamine hydrochloride

Conditions

Conditions	Yield
In tetrahydrofuran at 0℃; for 0.00694444h; Flow reactor; Green chemistry;	A 90% B n/a

...Expand

: 50893-53-3
carbonochloridic acid 1-chloro-ethyl ester

: 121-44-8
triethylamine

: 75-08-1
ethanethiol

A: 554-68-7
triethylamine hydrochloride

B: 101506-43-8
O-(1-chloroethyl) S-ethyl carbonothioate

Conditions

Conditions	Yield
In diethyl ether at 0 - 20℃; for 5h;	A n/a B 89%

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: 2-(2,4-dimethoxyphenyl)-3-(2-nitrobenzenesulfenyl)-4(S)-phenyl-5(R)-oxazolidinecarboxylic acid sodium salt

: 554-68-7
triethylamine hydrochloride

: triethylammonium 2-(2,4-dimethoxyphenyl)-3-(2-nitrobenzenesulfenyl)-4-phenyl-5-oxazolidinecarboxylate

Conditions

Conditions	Yield
In methanol for 3h;	100%

: closo-[tetraphenylphosphonium]2[B8H8]

: 554-68-7
triethylamine hydrochloride

: closo-[tetraphenylphosphonium][B8H9]

Conditions

Conditions	Yield
In acetonitrile (Ar); MeCN added to B compd. and N(C2H5)3HCl, stirred for 15 min; Et2O added carefully, crystd. for 5 d, dried (vac., overnight), H2O added, stirred for 15 min, sepd., washed (H2O), dried (vac.);	100%

: 554-68-7
triethylamine hydrochloride

: copper(l) chloride

: C6H15N*ClH*CuCl

Conditions

Conditions	Yield
at 60℃; for 4h; Inert atmosphere; Sealed tube;	100%

: 3459-92-5
DBC

: 554-68-7
triethylamine hydrochloride

: 56-37-1
N-benzyl-N,N,N-triethylammonium chloride

Conditions

Conditions	Yield
With 1-ethyl-3-methylimidazolium bromide at 169.84℃; for 8h;	99%

: 554-68-7
triethylamine hydrochloride

: 616-38-6
carbonic acid dimethyl ester

: 10052-47-8
triethylmethylammonium chloride

Conditions

Conditions	Yield
With 1-ethyl-3-methylimidazolium bromide at 169.84℃; for 8h;	99%
With 1-ethyl-3-methylimidazolium bromide at 169.84℃; for 8h;

: 137003-15-7
(Bu4N)2[Fe4S4(1,3,5-tris-((4,6-dimethyl-3-mercaptophenyl)thio)-2,4,6-tris-(p-tolylthio)benzenate(3-))(SC2H5)]

: 554-68-7
triethylamine hydrochloride

: (Bu4N)2[Fe4S4(1,3,5-tris-((4,6-dimethyl-3-mercaptophenyl)thio)-2,4,6-tris-(p-tolylthio)benzenate(3-))Cl]

Conditions

Conditions	Yield
In acetonitrile byproducts: Et3N, EtSH; N2-atmosphere; stirring equimolar amts. for 12 h (periodic removal of Et3N and EtSH by evacuation); filtration, solvent removal (vac.);	99%

: (Bu4N)2[Fe4Se4(1,3,5-tris-((4,6-dimethyl-3-mercaptophenyl)thio)-2,4,6-tris-(p-tolylthio)benzenate(3-))(SC2H5)]

: 554-68-7
triethylamine hydrochloride

: (Bu4N)2[Fe4Se4(1,3,5-tris-((4,6-dimethyl-3-mercaptophenyl)thio)-2,4,6-tris-(p-tolylthio)benzenate(3-))Cl]

Conditions

Conditions	Yield
In acetonitrile byproducts: Et3N, EtSH; N2-atmosphere; stirring equimolar amts. for 12 h (periodic removal of Et3N and EtSH by evacuation); filtration, solvent removal (vac.);	99%

: 1266146-97-7
[(1,3-C6H3(CH2P(CF3)2)2)Ir(H)Cl(η2-C2H4)]

: 554-68-7
triethylamine hydrochloride

: 1268160-20-8
[(1,3-C6H3(CH2P(CF3)2)2)Ir(H)Cl2][HNEt3]

Conditions

Conditions	Yield
In benzene (N2); glovebox technique; mixt. of Ir complex (1 equiv.) and Et3NHCl (1 equiv.) in C6H6 was agitated at 20°C for 20 min;	99%

: 609-67-6
2-Iodobenzoyl chloride

: 554-68-7
triethylamine hydrochloride

: 15310-01-7
benodanil

Conditions

Conditions	Yield
With triethylamine; aniline In water; benzene	98%

: 554-68-7
triethylamine hydrochloride

: 79-04-9
chloroacetyl chloride

: 173026-14-7
3,3-dimethyl-7-nitrobenzisoselenazoline

: 204272-78-6
N-(chloroacetyl)-3,3-dimethyl-7-nitrobenzisoselenazoline

Conditions

Conditions	Yield
With sodium chloride In tetrahydrofuran; water; ethyl acetate	97%

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Triethylamine hydrochloride Consensus Reports

Reported in EPA TSCA Inventory.

Triethylamine hydrochloride Specification

The Triethylamine hydrochloride with CAS registry number of 554-68-7 is also known as Ethanamine, N,N-diethyl-, hydrochloride. The IUPAC name is N,N-Diethylethanamine hydrochloride. It belongs to product categories of HPLC; HPLC buffer; HPLC buffers; HPLC Buffers-solutionchromatography/ce Reagents; Solution. Its EINECS registry number is 209-067-2. In addition, the formula is C₆H₁₆ClN and the molecular weight is 137.65. This chemical is a white to off-white crystalline powder and should be stored sealed containers.

Physical properties about Triethylamine hydrochloride are: (1)ACD/LogP: 1.66; (2)ACD/LogD (pH 5.5): -1.44; (3)ACD/LogD (pH 7.4): -1.2; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 1; (7)ACD/KOC (pH 7.4): 1; (8)#H bond acceptors: 1; (9)#Freely Rotating Bonds: 3; (10)Flash Point: 39 °C; (11)Enthalpy of Vaporization: 31.01 kJ/mol; (12)Boiling Point: 90.5 °C at 760 mmHg; (13)Vapour Pressure: 56.1 mmHg at 25 °C.

Preparation of Triethylamine hydrochloride: it is prepared by reaction of methyl-prop-2-ynyl-amine. The reaction needs reagents POCl₃, (C₂H₅)₃N at the temperature of 1-20 °C. The yield is about 59.8%.

Triethylamine hydrochloride is prepared by reaction of methyl-prop-2-ynyl-amine.

Uses of Triethylamine hydrochloride: it is used as raw material for quaternary ammonium salt, medicine, pesticides, dyes and other organic synthesis. It is used to produce triethylammonium salt of monobutyl phosphonate by reaction with phosphonic acid dibutyl ester. The reaction occurs at the temperature of 145 °C and the yield is about 85%.

Triethylamine hydrochloride is used to produce triethylammonium salt of monobutyl phosphonate by reaction with phosphonic acid dibutyl ester.

When you are using this chemical, please be cautious about it. As a chemical, it is irritating to eyes, respiratory system and skin. Besides, it is harmful by inhalation, in contact with skin and if swallowed. During using it, wear suitable protective clothing, gloves and eye/face protection. Do not breathe dust. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
1. Canonical SMILES: CCN(CC)CC.Cl
2. InChI: InChI=1S/C6H15N.ClH/c1-4-7(5-2)6-3;/h4-6H2,1-3H3;1H
3. InChIKey: ILWRPSCZWQJDMK-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LDLo	subcutaneous	600mg/kg (600mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 37, Pg. 309, 1929.

Product Name

Triethylamine hydrochloride

Synthetic route

Triethylamine hydrochloride Consensus Reports

Triethylamine hydrochloride Specification

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