Trimethylamine supplier | CasNO.75-50-3

Name
Trimethylamine
EINECS 200-875-0
CAS No. 75-50-3
Article Data664
CAS DataBase
Density 0.692 g/cm³
Solubility
Melting Point 283-284 °C (dec.)(lit.)
Formula N(CH₃)₃
Boiling Point 2.8 °C at 760 mmHg
Molecular Weight 59.1112
Flash Point 38 °F
Transport Information UN 2924 3/PG 2
Appearance colourless gas
Safety 26-36-45-36/37/39-16-29
Risk Codes 36/37/38-34-20/22-12-41-37/38-20
Molecular Structure
Hazard Symbols Xi,C,F+,Xn
Synonyms Trimethylamine(8CI);N,N-Dimethylmethanamine;N-Trimethylamine;
PSA 3.24000
LogP 0.17780

Synthetic route

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: 75-50-3
trimethylamine

Conditions

Conditions	Yield
With Dimethylphenylsilane; C40H56FeN2Si4(2-) In benzene-d6 at 120℃; for 10h; Reagent/catalyst; Sealed tube; Inert atmosphere;	99%
With bis(tetrahydrofuran)calcium di(bis(trimethylsilyl)amide); 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane In benzene-d6 at 25℃; for 4h; Inert atmosphere; Schlenk technique; Glovebox;	99%
With sodium tetrahydroborate; Bis-(2-bromoethyl)selenium dibromide In tetrahydrofuran at 65℃; for 4h; Product distribution; Mechanism; other temperature (25 deg C), other reaction time, also presence od diethyl selenium dibromide; various other tertiary amides investigated;	82%

: 766-77-8
Dimethylphenylsilane

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: 75-50-3
trimethylamine

Conditions

Conditions	Yield
With C40H56N2RuSi4 at 120℃; for 5h; Reagent/catalyst; Sealed tube;	99%
With bis(1,5-cyclooctadiene)dichloro[1,3-bis(1′-butylbenzimidazol-2′-yliden-3′-yl)benzene]dirhodium(I) In benzene-d6 at 100℃; for 2h; Catalytic behavior; Time; Reagent/catalyst;	89%

: 124-38-9
carbon dioxide

: 75-50-3
trimethylamine

Conditions

Conditions	Yield
With aluminium(III) triflate; [Ru(Triphos)(TMM)]; hydrogen; ammonium chloride In 1,4-dioxane; water at 150℃; under 67506.8 Torr; for 24h; Solvent; Temperature; Pressure; Autoclave; Schlenk technique;	99%
With octane; hydrogen; ammonium bicarbonate In neat (no solvent) at 250℃; for 24h; Catalytic behavior; Reagent/catalyst; Solvent; Autoclave;	65%
With aluminium(III) triflate; [Ru(1,1,1-tris(diphenylphosphinomethyl)ethane)(trimethylenemethane)]; ammonia; hydrogen; bis(trifluoromethanesulfonyl)amide In 1,4-dioxane at 150℃; under 60006 Torr; for 24h; Catalytic behavior; Reagent/catalyst; Solvent; Temperature; Time; Inert atmosphere; Autoclave;	77 %Spectr.

: 85598-30-7
C17H18ClN3O

A: 28825-13-0
5-(4-chlorophenyl)-3-phenyl-1,2,4-oxadiazole

B: 75-50-3
trimethylamine

Conditions

Conditions	Yield
at 215℃; for 0.25h;	A 98% B n/a

: 617-86-7
triethylsilane

: 51-80-9
bis-(dimethylamino)methane

A: 3550-35-4
1,1,1-triethyl-N,N-dimethylsilylamine

B: 75-50-3
trimethylamine

Conditions

Conditions	Yield
With nickel at 140 - 150℃;	A 97% B n/a

...Expand

: 85598-29-4
C17H19N3O

A: 888-71-1
3,5-diphenyl-1,2,4-oxadiazole

B: 75-50-3
trimethylamine

Conditions

Conditions	Yield
at 210℃; for 0.0833333h;	A 97% B n/a

: 85715-90-8
C18H21N3O

A: 16112-24-6
3-phenyl-5-(p-tolyl)-1,2,4-oxadiazole

B: 75-50-3
trimethylamine

Conditions

Conditions	Yield
at 210℃; for 0.166667h;	A 97% B n/a

: 108546-39-0
[(E)-4-(Diethoxy-phosphorylsulfanyl)-but-2-enyl]-trimethyl-ammonium; chloride

A: 1623-14-9
ethyl phosphate

B: 10574-85-3
ethyl 1,3-butadienyl sulfide

C: 75-50-3
trimethylamine

Conditions

Conditions	Yield
With potassium hydroxide at 110℃; Product distribution; Mechanism;	A 85.4% B 33.3% C 96.3%

...Expand

: 856617-42-0
trimethyl-borane; compound with trimethylamine

A: 593-90-8
trimethylborane

B: 75-50-3
trimethylamine

Conditions

Conditions	Yield
at 111.3°C, 64.5 Torr equilibrium;	A 96% B 96%
at 111.3°C, 64.5 Torr equilibrium;	A 96% B 96%
at 65.8°C, 47.5 Torr equilibrium;	A 63.8% B 63.8%

: propylborane; compound with trimethylamine (1:1)

: 95-54-5
1,2-diamino-benzene

A: 115002-30-7
2-propyl-2,3-dihydro-1H-benzo[1,3,2]diazaborole

B: 75-50-3
trimethylamine

Conditions

Conditions	Yield
In benzene byproducts: H2; by heating at reflux then cooling, adding pentane to the mixture; recrystn. from benzene-pentane;	A 95% B n/a

...Expand

: isobutylborane; compound with trimethylamine (1:1)

: 95-54-5
1,2-diamino-benzene

A: 114328-55-1
2-isobutyl-2,3-dihydro-1H-benzo[1,3,2]diazaborole

B: 75-50-3
trimethylamine

Conditions

Conditions	Yield
In benzene byproducts: H2; reflux, then cooling and adding pentane to the mixture; recrystn. from benzene-pentane;	A 95% B n/a

...Expand

: 18551-79-6
bis-[(diethoxy-methyl-silanyl)-methyl]-methyl-amine

: 108-95-2
phenol

A: 3439-97-2
methyltriphenoxysilane

B: 75-50-3
trimethylamine

Conditions

Conditions	Yield
for 1.5h; Heating;	A 92% B n/a

...Expand

: sec-butyl-borane; compound with trimethylamine (1:1)

: 95-54-5
1,2-diamino-benzene

A: 114328-54-0
2-sec-butyl-2,3-dihydro-1H-benzo[1,3,2]diazaborole

B: 75-50-3
trimethylamine

Conditions

Conditions	Yield
In benzene byproducts: H2; by heating at reflux, then cooling and adding pentane to the mixture; recrystn. from benzene-pentane;	A 92% B n/a

...Expand

: 124287-34-9
trimethylamine-1-benzylborane

: 95-54-5
1,2-diamino-benzene

A: 124139-26-0
2-benzyl-2,3-dihydro-1H-benzo[1,3,2]diazaborole

B: 75-50-3
trimethylamine

Conditions

Conditions	Yield
In benzene byproducts: H2; reflux, cooling then adding pentane to the mixture; crystn. from benzene-pentane;	A 92% B n/a

...Expand

: potassium sulfite

A: potassium dithionate

B: 75-50-3
trimethylamine

Conditions

Conditions	Yield
With (CH3)3NSO3 In further solvent(s) 12°C, hydrogencarbonatalkal. soln.; cooling the mixture with ice;	A 92% B n/a
With (CH3)3NSO3 In further solvent(s) 12°C, hydrogencarbonatalkal. soln.; cooling the mixture with ice;	A 92% B n/a

: isopropylborane; compound with trimethylamine (1:1)

: 95-54-5
1,2-diamino-benzene

A: 125929-63-7
2-isopropyl-2,3-dihydro-1H-1,3,2-benzodiazaborole

B: 75-50-3
trimethylamine

Conditions

Conditions	Yield
In benzene byproducts: H2; by heating at reflux, then cooling and adding pentane to the mixture; recrystn. from benzene-pentane;	A 91% B n/a

...Expand

: 382156-73-2
C15H37NO6Si2

: 108-95-2
phenol

A: 1174-72-7
tetraphenoxysilane

B: 75-50-3
trimethylamine

Conditions

Conditions	Yield
for 1.5h; Heating;	A 89% B n/a

...Expand

: cyclohexylborane; compound with trimethylamine (1:1)

: 95-54-5
1,2-diamino-benzene

A: 108484-20-4
2-cyclohexyl-2,3-dihydro-1H-benzo[1,3,2]diazaborole

B: 75-50-3
trimethylamine

Conditions

Conditions	Yield
In benzene byproducts: H2; by heating at reflux, cooling and adding pentane to the mixture; recrystn. from benzene-pentane;	A 89% B n/a

...Expand

: 1013940-31-2
acetic acid 15-allyl-3-benzyloxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl ester

A: 1013940-33-4
acetic acid 3-benzyloxy-15-(3-hydroxy-propyl)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl ester

B: 75-50-3
trimethylamine

Conditions

Conditions	Yield
Stage #1: acetic acid 15-allyl-3-benzyloxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl ester With 9-bora-bicyclo[3.3.1]nonane In tetrahydrofuran at 10 - 20℃; for 4h; Stage #2: With trimethylamine-N-oxide In tetrahydrofuran; ethanol; diethylene glycol dimethyl ether at 150℃; for 1h;	A 89% B n/a

: 85598-33-0
C12H15Cl2N3O

A: 59562-67-3
5-(2,4-dichloro-phenyl)-3-methyl-[1,2,4]oxadiazole

B: 75-50-3
trimethylamine

Conditions

Conditions	Yield
at 170℃; for 0.5h;	A 88% B n/a

: tetrakis(dimethylamido)titanium(IV)

: ZrCl4*2N(CH3)3

A: 82089-50-7
ZrCl4Ti(N(CH3)2)4

B: 75-50-3
trimethylamine

Conditions

Conditions	Yield
In pentane under N2, Ti(NMe2)4 in n-pentane added dropwise to suspn. of ZrCl4*2NMe3 in n-pentane, stirred for 24 h; ppt. collected, washed with n-hexane, dried in vac. for 3 h at room temp.; elem. anal.;	A 85.7% B n/a

...Expand

: bis-[(ethoxy-dimethyl-silanyl)-methyl]-methyl-amine

: 108-95-2
phenol

A: 3440-02-6
dimethyl-diphenoxy-silane

B: 75-50-3
trimethylamine

Conditions

Conditions	Yield
for 1.5h; Heating;	A 85% B n/a

...Expand

: butylborane; compound with trimethylamine (1:1)

: 95-54-5
1,2-diamino-benzene

A: 31748-14-8
2-butyl-2,3-dihydro-1H-benzo[1,3,2]diazaborole

B: 75-50-3
trimethylamine

Conditions

Conditions	Yield
In benzene byproducts: H2; reflux, then cooling and adding pentane to the mixture; recrystn. from benzene-pentane;	A 85% B n/a

...Expand

: (μ-pyridyl)(μ-hydrido)dirhenium octacarbonyl

: 62637-93-8
trimethylamine-N-oxide dihydrate

A: 84538-00-1
(μ-hydrido)(μ-pyridyl)(trimethylamine N-oxide)dirhenium heptacarbonyl

B: 75-50-3
trimethylamine

Conditions

Conditions	Yield
In dichloromethane Re complex dissolved in CH2Cl2, excess Me3NO*2H2O added, stirred vigorously at room temp. for 10 h; filtered, filtrate washed with water, hexane added, slowly evapd.; elem. anal.;	A 84% B n/a

...Expand

: 1184-78-7
trimethylamine-N-oxide

: 75-50-3
trimethylamine

Conditions

Conditions	Yield
With C55H43P3Rh(1+)*C32H12BF24(1-); isopropyl alcohol at 80℃; for 24h; Reagent/catalyst; Inert atmosphere;	82%
biochemische Reduktion durch gaerende Zucker-Loesungen;
With zinc

: 186581-53-3, 908094-01-9
diazomethane

: 104815-74-9
methylammonium 1-methylcaffolide

A: 7366-48-5
3,6,8-trimethyl-1-oxa-3,6,8-triaza-spiro[4.4]nonane-2,4,7,9-tetraone

B: 75-50-3
trimethylamine

Conditions

Conditions	Yield
In diethyl ether for 48h;	A 80% B n/a

...Expand

: 186581-53-3, 908094-01-9
diazomethane

: 104795-02-0
ammonium caffolide

A: 7366-48-5
3,6,8-trimethyl-1-oxa-3,6,8-triaza-spiro[4.4]nonane-2,4,7,9-tetraone

B: 75-50-3
trimethylamine

Conditions

Conditions	Yield
In diethyl ether for 48h;	A 80% B n/a

...Expand

: 186581-53-3, 908094-01-9
diazomethane

: 105116-10-7
ammonium 1,3-dimethylcaffolide

A: 7366-48-5
3,6,8-trimethyl-1-oxa-3,6,8-triaza-spiro[4.4]nonane-2,4,7,9-tetraone

B: 75-50-3
trimethylamine

Conditions

Conditions	Yield
In diethyl ether for 48h;	A 80% B n/a

...Expand

: cis-tetracarbonyl(2-ethoxy-2-oxoethyl)(triphenylphosphine)rhenium

: 1184-78-7
trimethylamine-N-oxide

: fac-(MeCN)(OC)3(Ph3)ReCH2COOEt

B: 124-38-9
carbon dioxide

C: 75-50-3
trimethylamine

Conditions

Conditions	Yield
	A 80% B n/a C n/a

...Expand

: hexylborane; compound with trimethylamine (1:1)

: 95-54-5
1,2-diamino-benzene

A: 124138-66-5
2-hexyl-2,3-dihydro-1H-benzo[1,3,2]diazaborole

B: 75-50-3
trimethylamine

Conditions

Conditions	Yield
In benzene byproducts: H2; reflux, then cooling and adding pentane to the mixture; recrystn. from benzene-pentane;	A 79% B n/a

...Expand

: 104-81-4
4-Methylbenzyl bromide

: 75-50-3
trimethylamine

: 16814-21-4
(4-methylbenzyl)trimethylammonium bromide

Conditions

Conditions	Yield
In diethyl ether at 0 - 20℃;	100%
In tetrahydrofuran; ethanol at 25℃; for 24h; Inert atmosphere;	99%

: 627-42-9
2-chloroethyl methyl ether

: 75-50-3
trimethylamine

: 6340-44-9
Choline methyl ether chloride

Conditions

Conditions	Yield
In water; acetonitrile at 140℃; for 5.5h;	100%
In ethanol at 180℃; for 2.5h;	93%
at 95℃;

: 1120-71-4
1,3-propanesultone

: 75-50-3
trimethylamine

: 21865-17-8
N-(3-sulfonatopropyl)-N,N,N-trimethylammonium

Conditions

Conditions	Yield
In ethanol; acetone at 0 - 20℃; for 24h;	100%
In acetone at 35℃; for 2h;	86%
In benzene

: 41197-29-9
dichloromethanesulphonyl chloride

: 124-63-0
methanesulfonyl chloride

: 75-50-3
trimethylamine

A: 25004-95-9
trichloromethanesulfinyl chloride

B: 14843-83-5
Trimethylammonium-(methylsulfonyl)methansulfonat

Conditions

Conditions	Yield
In tetrahydrofuran at -70℃;	A 55% B 100%

...Expand

: 868-85-9
Dimethyl phosphite

: 75-50-3
trimethylamine

: tetramethylammonium methyl hydrogen phosphite

Conditions

Conditions	Yield
at 20℃; for 24h;	100%

: 41197-29-9
dichloromethanesulphonyl chloride

: 75-50-3
trimethylamine

: 98182-00-4
trimethylammonium trichloromethanesulfinate

Conditions

Conditions	Yield
In tetrahydrofuran at -70℃;	100%

: 130972-90-6
tert-butyl N-[4-(2-bromoethoxy)-3-methoxybenzyl]carbamate

: 75-50-3
trimethylamine

: {2-[4-(tert-Butoxycarbonylamino-methyl)-2-methoxy-phenoxy]-ethyl}-trimethyl-ammonium; bromide

Conditions

Conditions	Yield
In methanol for 18h; Heating;	100%

: 5,10,15,20-tetrakis(4’-bromomethylphenyl)porphyrin

: 75-50-3
trimethylamine

: 5,10,15,20-tetrakis(α-trimethylammonio-4-methylphenyl)phenylporphyrin tetrabromide

Conditions

Conditions	Yield
In ethanol at 80℃; for 14h; Substitution;	100%
In ethanol; chloroform Reflux;	91%
In ethanol at 80℃; for 14h;	49%

: 258336-21-9
Toluene-4-sulfonic acid (2R,4R,5R)-5-[1,3]dioxolan-2-yl-4-hydroxy-tetrahydro-furan-2-ylmethyl ester

: 75-50-3
trimethylamine

: Toluene-4-sulfonate((2R,4R,5R)-5-[1,3]dioxolan-2-yl-4-hydroxy-tetrahydro-furan-2-ylmethyl)-trimethyl-ammonium;

Conditions

Conditions	Yield
In ethanol at 80℃; for 24h; Substitution;	100%

: C48H36N4O2Ru

: 75-50-3
trimethylamine

: (meso-Tetrakis{p-tolyl}porphyrinato)bis(trimethylamine)ruthenium(II)

Conditions

Conditions	Yield
With water for 1h; Reduction;	100%

: C44H24Cl4N4O2Ru

: 75-50-3
trimethylamine

: (meso-Tetrakis{p-chlorophenyl}porphyrinato)bis(trimethylamine)ruthenium(II)

Conditions

Conditions	Yield
With water for 1h; Reduction;	100%

: 287178-85-2
N-tert-Butyloxycarbonyl-L-glutaminyl-L-threonine 2-bromoethyl ester

: 75-50-3
trimethylamine

: N-tert-Butyloxycarbonyl-L-glutaminyl-L-threonine choline ester bromide

Conditions

Conditions	Yield
In acetone at 20℃; for 72h; Alkylation;	100%

: 1-bromo-2,4-hexadecadiyne

: 75-50-3
trimethylamine

: 2,4-hexadecadiynyltrimethylammonium bromide

Conditions

Conditions	Yield
In water at 20℃;	100%

: 10310-21-1
2-Amino-6-chloropurin

: 75-50-3
trimethylamine

: 34798-95-3
2-amino-N,N,N-trimethyl-9H-purine-6-ylammonium chloride

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 20℃; for 1h; Inert atmosphere;	100%
In ethanol; dimethyl sulfoxide at 20℃; for 12h;	76%
In dimethyl sulfoxide for 12h;	72%

: 62707-38-4
2-(N-acetylanilino)-4-chloromethyl-1,3-selenazole

: 75-50-3
trimethylamine

: [2-(N-acetylanilino)-1,3-selenazol-4-ylmethyl]trimethylammonium chloride

Conditions

Conditions	Yield
In benzene at 20℃; for 2h;	100%

: 121995-12-8
2-(N-acetylanilino)-4-iodomethyl-1,3-selenazole

: 75-50-3
trimethylamine

: [2-(N-acetylanilino)-1,3-selenazol-4-ylmethyl]trimethylammonium iodide

Conditions

Conditions	Yield
In benzene at 20℃; for 2h;	100%

: 17118-00-2, 30002-85-8, 84773-09-1
1,4-anhydro-2,3-O-isopropylidene-5-O-toluene-p-sulphonyl-DL-ribitol

: 75-50-3
trimethylamine

: N-(1,4-anhydro-2,3-O-isopropylidene-D,L-ribitol-5-yl)trimethylammonium tosylate

Conditions

Conditions	Yield
In ethanol at 70℃; for 0.25h;	100%

: 4,16-bis(6'-bromohexyl)[2.2]paracyclophane

: 75-50-3
trimethylamine

: 4,16-bis(6'-(N,N,N-trimethylammonium)hexyl)[2.2]paracyclophane dibromide

Conditions

Conditions	Yield
In tetrahydrofuran at -78 - 20℃; for 24h;	100%

: 854669-58-2
1,4-bis(3',5'-bis(6''-bromohexyl)styryl)benzene

: 75-50-3
trimethylamine

: 1,4-bis(3',5'-bis(6'-(N,N,N-trimethylammonium)hexyl)styryl)benzene tetrabromide

Conditions

Conditions	Yield
In tetrahydrofuran at -78 - 20℃; for 24h;	100%

: 1,4-bis(4'-(N,N-bis(6''-iodohexyl)amino)styryl)benzene

: 75-50-3
trimethylamine

: 1,4-bis(4'-(N,N-bis(6''-(N,N,N-trimethylammonium)hexyl)amino)styryl)benzene tetraiodide

Conditions

Conditions	Yield
In tetrahydrofuran at -78 - 20℃; for 24h;	100%
In tetrahydrofuran; water at -78 - 20℃; for 24h;	92%

: 868860-21-3
1-(bromomethyl)-2,5-dichloro-4-methylbenzene

: 75-50-3
trimethylamine

: 2,5-dichloro-(4-methylbenzyl)trimethylammonium bromide

Conditions

Conditions	Yield
In diethyl ether at 0 - 20℃;	100%
In diethyl ether at 0 - 20℃;

: 32330-80-6
[14C2-1,4]-1,4-dibromobutane

: 75-50-3
trimethylamine

: C8(14)C2H26N2(2+)*2Br(1-)

Conditions

Conditions	Yield
In ethanol	100%

: 134457-14-0
4,4'-bis(bromomethyl)-2,2'-bipyridine

: 75-50-3
trimethylamine

: 4,4’‐bis(trimethylammoniummethyl)‐2,2’‐bipyridine

Conditions

Conditions	Yield
In dichloromethane; water at 20℃; for 24h;	100%
In ethanol; water at 20℃; for 1h; Inert atmosphere;	100%
In ethanol; water at 20℃; for 1h;
In dichloromethane; water at 20℃; for 24h;
In dichloromethane at 20℃; for 24h;

: 5,15-bis-[4-(3-bromo-propyloxy)-phenyl]-porphyrin

: 75-50-3
trimethylamine

: 5,15-bis-[4-(3-trimethylammonio-propyloxy)-phenyl]-porphyrin dibromide

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 50℃; under 750.075 - 1500.15 Torr; for 17h; Autoclave; Industry scale;	100%

: 16842-00-5
trimethylaminealane

: 75-50-3
trimethylamine

: bis(trimethylamino) alane

Conditions

Conditions	Yield
In not given react. of the Al compd. with an excess of NMe3;	100%

: 1187956-06-4
6-methylbenzofuran-3-ylmethyl bromide

: 75-50-3
trimethylamine

: 1187956-09-7
Br(1-)*C13H18NO(1+)

Conditions

Conditions	Yield
In tetrahydrofuran; chloroform at 20℃; Inert atmosphere;	100%

: 38281-49-1
3-bromomethylbenzofuran

: 75-50-3
trimethylamine

: 1187956-08-6
Br(1-)*C12H16NO(1+)

Conditions

Conditions	Yield
In tetrahydrofuran; chloroform at 20℃; Inert atmosphere;	100%

: 2417-72-3
Methyl 4-(bromomethyl)benzoate

: 75-50-3
trimethylamine

: 1192363-78-2
1-(4-(methoxycarbonyl)phenyl)-N,N,N-trimethylmethanammonium bromide

Conditions

Conditions	Yield
In water; acetonitrile at 80℃; for 15h; Sealed flask;	100%
In acetonitrile at 50℃; for 12h;

: 1231718-49-2
1-(2,3-dioleyl-5-O-tosyl-α-D-ribofuranosyl)-4-nitroimidazole

: 75-50-3
trimethylamine

: 1231718-52-7
1-(2,3-dioleyl-5-trimethylammonium-α-D-ribofuranosyl)-4-nitroimidazole tosylate

Conditions

Conditions	Yield
In tetrahydrofuran; acetonitrile at 50℃; for 48h;	100%

: 1231718-39-0
1-(2,3-dioleyl-5-O-tosyl-α-D-ribofuranosyl)-5-nitroindole

: 75-50-3
trimethylamine

: 1231718-42-5
1-(2,3-dioleyl-5-trimethylammonium-α-D-ribofuranosyl)-5-nitroindole tosylate

Conditions

Conditions	Yield
In tetrahydrofuran; acetonitrile at 50℃; for 48h;	100%

Trimethylamine Consensus Reports

Reported in EPA TSCA Inventory.

Trimethylamine Standards and Recommendations

OSHA PEL: TWA 10 ppm; STEL 15 ppm
ACGIH TLV: TWA 5 ppm; STEL 15 ppm
DOT Classification: 2.1; Label: Flammable Gas (UN 1083); DOT Class: 3; Label: Flammable Liquid (UN 1297)

Trimethylamine Specification

The Trimethylamine, also known as Dimethylmethaneamine, is an organic compound with the formula N(CH₃)₃. It belongs to the product categories of Alphabetical Listings; Flavors and Fragrances; Q-Z; Amines; C2 to C6; Nitrogen Compounds; Chemical Synthesis; Compressed and Liquefied Gases; Synthetic Reagents; Q-ZFlavors and Fragrances; Redi-Pack Bulk; Compressed and Liquefied Gases Alphabetic; TP - TZ. Its EINECS registry number is 200-875-0. With the CAS registry number 75-50-3, its IUPAC name is N,N-dimethylmethanamine. It is a gas at room temperature but is usually sold in pressurized gas cylinders or as a 40% solution in water.

Physical properties of Trimethylamine: (1)ACD/LogP: 0.06; (2)ACD/LogD (pH 5.5): -3.01; (3)ACD/LogD (pH 7.4): -2.22; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 1; (7)ACD/KOC (pH 7.4): 1; (8)#H bond acceptors: 1; (9)Index of Refraction: 1.378; (10)Molar Refractivity: 19.66 cm³; (11)Molar Volume: 85.3 cm³; (12)Surface Tension: 18.6 dyne/cm; (13)Density: 0.692 g/cm³; (14)Enthalpy of Vaporization: 22.94 kJ/mol; (15)Boiling Point: 2.8 °C at 760 mmHg; (16)Vapour Pressure: 1720 mmHg at 25°C.

Preparation: Trimethylamine is prepared by the reaction of ammonia and methanol employing a catalyst. This reaction coproduces the other methylamines, dimethylamine (CH₃)₂NH and methylamine CH₃NH₂.

3 CH₃OH + NH₃ → (CH₃)₃N + 3 H₂O

Uses: Trimethylamine is used in the synthesis of choline, tetramethylammonium hydroxide, plant growth regulators, strongly basic anion exchange resins, dye leveling agents and a number of basic dyes. Gas sensors to test for fish freshness detect trimethylamine.

When you are using this chemical, please be cautious about it as the following:
This chemical may cause inflammation to the skin or other mucous membranes. It is irritating to eyes, respiratory system and skin. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. Whenever you will contact it, please wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell seek medical advice immediately (show the label where possible).

You can still convert the following datas into molecular structure:
(1)Canonical SMILES: CN(C)C
(2)InChI: InChI=1S/C3H9N/c1-4(2)3/h1-3H3
(3)InChIKey: GETQZCLCWQTVFV-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
frog	LDLo	subcutaneous	2gm/kg (2000mg/kg)	CARDIAC: PULSE RATE CARDIAC: OTHER CHANGES BLOOD: OTHER CHANGES	Skandinavisches Archiv fuer Physiologie. Vol. 10, Pg. 201, 1900.
guinea pig	LD50	unreported	315mg/kg (315mg/kg)		Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 46(8), Pg. 79, 1981.
mammal (species unspecified)	LC50	inhalation	19gm/m³ (19000mg/m³)		Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 14, Pg. 80, 1975.
mouse	LC50	inhalation	19gm/m³ (19000mg/m³)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: EXCITEMENT BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)	Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 11(4), Pg. 26, 1967.
mouse	LD50	intraperitoneal	946mg/kg (946mg/kg)		Yakugaku Zasshi. Journal of Pharmacy. Vol. 97, Pg. 1117, 1977.
mouse	LD50	intravenous	90mg/kg (90mg/kg)		Medicina et Pharmacologia Experimentalis. Vol. 16, Pg. 529, 1967.
mouse	LD50	unreported	460mg/kg (460mg/kg)		Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 46(8), Pg. 79, 1981.
pig	LDLo	oral	1gm/kg (1000mg/kg)	PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE BEHAVIORAL: FOOD INTAKE (ANIMAL)	Inhalation Toxicology. Vol. 2, Pg. 41, 1990.
rabbit	LD50	unreported	240mg/kg (240mg/kg)		Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 46(8), Pg. 79, 1981.
rabbit	LDLo	intravenous	160mg/kg (160mg/kg)		Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. Vol. 83, Pg. 481, 1920.
rabbit	LDLo	rectal	800mg/kg (800mg/kg)		Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. Vol. 83, Pg. 481, 1920.
rabbit	LDLo	subcutaneous	800mg/kg (800mg/kg)		Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. Vol. 83, Pg. 481, 1920.
rat	LCLo	inhalation	3500ppm/4H (3500ppm)		Toxicologist. Vol. 4, Pg. 68, 1984.
rat	LD50	oral	500mg/kg (500mg/kg)		Inhalation Toxicology. Vol. 2, Pg. 41, 1990.
rat	LD50	unreported	535mg/kg (535mg/kg)		Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 46(8), Pg. 79, 1981.

Product Name

Trimethylamine

Synthetic route

Trimethylamine Consensus Reports

Trimethylamine Standards and Recommendations

Trimethylamine Specification

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