o-Phthalaldehyde supplier | CasNO.643-79-8

Name
o-Phthalaldehyde
EINECS 211-402-2
CAS No. 643-79-8
Article Data144
CAS DataBase
Density 1.189 g/cm³
Solubility Soluble in water
Melting Point 55-58 °C(lit.)
Formula C₈H₆O₂
Boiling Point 266.1 °C at 760 mmHg
Molecular Weight 134.134
Flash Point 98.5 °C
Transport Information UN2923 8/PG 2
Appearance Light yellow powder
Safety 26-28-36-45-36/37/39-61-37/39
Risk Codes 36/37/38-43-34-25-50
Molecular Structure
Hazard Symbols T, Xi, N
Synonyms 1,2-Benzenedicarboxaldehyde;Phthalic dialdehyde;Phtalaldehydes [French];Phthalic aldehyde;o-Phthaldialdehyde;Phthalyldicarboxaldehyde;Benzene-1,2-dicarboxaldehyde;2-Phthalaldehyde;o-Phthaladlehyde;Phthalic dicarboxaldehyde;
PSA 34.14000
LogP 1.31160

Synthetic route

: 612-14-6
phthalyl alcohol

: 643-79-8
o-phthalic dicarboxaldehyde

Conditions

Conditions	Yield
With bis(pyridine)silver(I) permanganate In benzene for 1h;	95%
With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione In neat (no solvent) at 20℃; for 2h; Milling;	86%
With tetrakis(pyridine)silver dichromate In benzene for 2h; Heating;	85%

: 59868-79-0
1,3-dihydroisobenzofuran-1-ol

: 524-38-9
N-hydroxyphthalimide

: 10102-43-9
nitrogen(II) oxide

: 643-79-8
o-phthalic dicarboxaldehyde

Conditions

Conditions	Yield
In acetonitrile	95%

...Expand

: 496-14-0
1,3-dihydroisobenzofuran

: 524-38-9
N-hydroxyphthalimide

: 10102-43-9
nitrogen(II) oxide

: 643-79-8
o-phthalic dicarboxaldehyde

Conditions

Conditions	Yield
In acetonitrile	94%

...Expand

: 1313208-32-0
C11H13NOS2

: 643-79-8
o-phthalic dicarboxaldehyde

Conditions

Conditions	Yield
With copper(II) choride dihydrate; water In acetonitrile at 75℃; for 1h;	92%

: 13209-15-9
1,2-bis(dibromomethyl)benzene

: 643-79-8
o-phthalic dicarboxaldehyde

Conditions

Conditions	Yield
Stage #1: 1,2-bis(dibromomethyl)benzene With sulfuric acid Stage #2: With water; sodium hydrogencarbonate Product distribution / selectivity;	91%
With sulfuric acid Product distribution / selectivity;	79%
With sulfuric acid

: 612-14-6
phthalyl alcohol

A: 55479-94-2
2-(hydroxymethyl)benzaldehyde

B: 643-79-8
o-phthalic dicarboxaldehyde

Conditions

Conditions	Yield
With 2,2'-bipyridylchromium peroxide In benzene for 0.8h; Product distribution; Heating; effect of various chromium(VI) based oxidants;	A 10% B 90%
With 2,2'-bipyridylchromium peroxide In benzene for 0.8h; Heating;	A 10% B 90%
With cucurbit[8]uril; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione In water for 0.0833333h; Catalytic behavior; Reagent/catalyst; Temperature; Reflux;	A 76% B 7%

: 6500-54-5
1,2-bis-diacetoxymethyl-benzene

: 643-79-8
o-phthalic dicarboxaldehyde

Conditions

Conditions	Yield
With ethanol at 50 - 60℃; for 0.0833333h;	90%
With poly(4-vinylpyridinium) hydrogen sulfate solid acid In methanol at 20℃; for 0.25h; Irradiation;	86%
With N-sulfonic acid poly(4-vinylpyridinium) chloride In methanol at 20℃; for 0.583333h;	82%

: 88-95-9
Phthaloyl dichloride

: 643-79-8
o-phthalic dicarboxaldehyde

Conditions

Conditions	Yield
With 1 Product distribution; further reagent;	89%
With pentacoordinated hydrogenosilane 3 further reagent;	89%
With Cp2M(CO)H (M= Nb or Ta) In diethyl ether Yield given;
With thexyl-s-butoxyborane In tetrahydrofuran at 25℃; for 120h; Yield given;

: 91-13-4
α,α'-dibromo-o-xylene

: 643-79-8
o-phthalic dicarboxaldehyde

Conditions

Conditions	Yield
With bis-{4-methoxy-phenyl}-selenoxyde; sodium hydrogencarbonate In acetonitrile at 75℃; for 5h;	84%
With air; sodium phenyltelluride 1.) THF, ethanol, reflux, 2 h, 2.) THF, ethanol, 25 deg C; Yield given. Multistep reaction;
Multi-step reaction with 2 steps 1: eosin y; oxygen / dimethyl sulfoxide / 12 h / 25 °C / Irradiation 2: eosin y / dimethyl sulfoxide / 24 h / 80 °C / Irradiation View Scheme

: 24388-70-3
1,3-dihydro-1,3-dimethoxybenzo[c]furan

: 643-79-8
o-phthalic dicarboxaldehyde

Conditions

Conditions	Yield
With hydrogenchloride In tetrachloromethane; water Reflux;	81%
With sulfuric acid; water under 112.511 Torr; for 4h; pH=2.0; Purification / work up;	61.5%
With water; benzene-1,2-dicarboxylic acid at 20℃; for 48h;	95 % Chromat.

: 34046-43-0
ethyl 2-formylbenzoate

: 643-79-8
o-phthalic dicarboxaldehyde

Conditions

Conditions	Yield
With n-butyllithium; diisobutylaluminium hydride; tert-butyl alcohol In tetrahydrofuran; hexane at 0℃;	81%

: 22882-30-0
cis-1,3-dihydro-1,3-dimethoxyisobenzofuran

: 643-79-8
o-phthalic dicarboxaldehyde

Conditions

Conditions	Yield
With hydrogenchloride; water In tetrachloromethane	81%

: 24388-71-4
1,3-diethoxyphthalan

: 643-79-8
o-phthalic dicarboxaldehyde

Conditions

Conditions	Yield
With sodium hydroxide; water for 0 - 1200h; pH=8.9; Product distribution / selectivity;	78.2%
With sodium hydroxide; water for 48 - 960h; pH=10.8; Product distribution / selectivity;	1%
With water; benzene-1,2-dicarboxylic acid at 20℃; for 24h;	95 % Chromat.

: 612-14-6
phthalyl alcohol

A: 87-41-2
2-benzofuran-1(3H)-one

B: 643-79-8
o-phthalic dicarboxaldehyde

Conditions

Conditions	Yield
With manganese(IV) oxide In dichloromethane for 2h;	A 77% B 15%
With Oxone; 2-iodo-3,4,5,6-tetramethylbenzoic acid In chloroform at 20℃; for 36h; Green chemistry;	A 67% B 30%
With ferric nitrate at 60℃; for 0.25h;	A 35% B 65%

: 91-20-3
naphthalene

: 643-79-8
o-phthalic dicarboxaldehyde

Conditions

Conditions	Yield
With potassium metaperiodate; potassium aquapentachlororuthenate(III) In dichloromethane; water; acetonitrile at 20℃; for 2h; Sonication;	75%
With potassium bromate In dichloromethane; water; acetonitrile at 20℃; for 1h; Reagent/catalyst; Temperature; Sonication;	68%
With sodium periodate In dichloromethane; water; acetonitrile at 20℃; for 1h; Irradiation;	60%

: 887143-97-7
2-(azidomethyl)benzaldehyde

: 643-79-8
o-phthalic dicarboxaldehyde

Conditions

Conditions	Yield
With iron(III) chloride; dihydrogen peroxide In dichloromethane; water for 16h; Reflux; Air;	75%

: 496-14-0
1,3-dihydroisobenzofuran

A: 87-41-2
2-benzofuran-1(3H)-one

B: 85-44-9
phthalic anhydride

C: 119-67-5
o-carboxybenzaldehyde

D: 643-79-8
o-phthalic dicarboxaldehyde

Conditions

Conditions	Yield
With dihydrogen peroxide; trifluoroacetic acid; zinc dibromide In 1,4-dioxane; water at 100℃; for 16h;	A 68% B n/a C n/a D n/a

...Expand

: 3155-65-5
N'-(2-hydroxybenzylidene)formohydrazide

: 643-79-8
o-phthalic dicarboxaldehyde

Conditions

Conditions	Yield
With lead(IV) acetate In tetrahydrofuran for 2h; Ambient temperature;	67%

: 496-14-0
1,3-dihydroisobenzofuran

: 612-14-6
phthalyl alcohol

A: 87-41-2
2-benzofuran-1(3H)-one

B: 643-79-8
o-phthalic dicarboxaldehyde

Conditions

Conditions	Yield
With nitric acid; acetic acid In water at 70℃; for 1h; Product distribution / selectivity;	A 11% B 67%

...Expand

: 91-15-6
phthalonitrile

: 643-79-8
o-phthalic dicarboxaldehyde

Conditions

Conditions	Yield
With C13H26B(1-)*K(1+) In tetrahydrofuran for 24h; Ambient temperature;	64%
With sodium tris(dibutylamino)aluminum hydride In tetrahydrofuran at 25℃; for 3h; Yield given;
Stage #1: phthalonitrile With lithium tris(dihexylamino)aluminum hydride In tetrahydrofuran at 0℃; for 1h; Reduction; Stage #2: With hydrogenchloride In tetrahydrofuran Hydrolysis;

: 99758-16-4
5-hydroxy-4,5-dihydroisobenzofuran

: 643-79-8
o-phthalic dicarboxaldehyde

Conditions

Conditions	Yield
With selenium(IV) oxide In water for 0.166667h; Heating;	64%
Multi-step reaction with 3 steps 1.1: sodium hydride / 1,4-dioxane / 0.25 h 1.2: 20 °C 2.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / 1,4-dioxane / 48 h / 20 °C 3.1: toluene-4-sulfonic acid; lithium chloride / N,N-dimethyl-formamide View Scheme

: 5-methoxy-4,5-dihydroisobenzofuran

A: 6500-51-2
4-methoxybenzene-1,2-dicarbaldehyde

B: 643-79-8
o-phthalic dicarboxaldehyde

Conditions

Conditions	Yield
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In 1,4-dioxane at 20℃; for 48h;	A 63% B n/a

: 109179-40-0
1,2-Bis-phenyltellanylmethyl-benzene

: 643-79-8
o-phthalic dicarboxaldehyde

Conditions

Conditions	Yield
With oxygen In acetonitrile for 24h; Irradiation;	56%

: 95-47-6
o-xylene

A: 529-20-4
2-methylphenyl aldehyde

B: 643-79-8
o-phthalic dicarboxaldehyde

Conditions

Conditions	Yield
With oxygen In water at 150℃; under 30002.4 Torr; for 2h;	A 20% B 42%
With oxygen; 10-methyl-9-phenylacridin-10-ium perchlorate In chloroform at 24.85℃; for 10h; photoirradiation; Title compound not separated from byproducts;
With oxygen; 10-methyl-9-phenylacridin-10-ium perchlorate In chloroform at 24.84℃; for 10h; Oxidation; Pyrolysis; visible light; Title compound not separated from byproducts.;
With oxygen at 300℃; Gas phase; Flow reactor;

: 91-20-3
naphthalene

A: 61650-52-0
(E)-2-(3-oxoprop-1-enyl)benzaldehyde

B: 93273-84-8
2-Formyl-cis-cinnamaldehyde

C: 643-79-8
o-phthalic dicarboxaldehyde

D: 130-15-4
[1,4]naphthoquinone

Conditions

Conditions	Yield
With florisil; helium dimer; oxygen at -78℃; for 2h;	A 30% B 40% C 20% D n/a
With florisil; helium dimer; oxygen at -78℃; for 2h; Mechanism;	A 30% B 40% C 20% D n/a
With florisil; ozone Product distribution; var. reaction time;

...Expand

: 496-14-0
1,3-dihydroisobenzofuran

A: 87-41-2
2-benzofuran-1(3H)-one

B: 643-79-8
o-phthalic dicarboxaldehyde

Conditions

Conditions	Yield
With nitric acid; acetic acid In water at 60 - 80℃; for 0.5 - 4h; Product distribution / selectivity;	A 9% B 35%
With nitric acid In dichloromethane at 20℃; for 1h;	A 39 % Spectr. B 61 % Spectr.

: 496-14-0
1,3-dihydroisobenzofuran

A: 87-41-2
2-benzofuran-1(3H)-one

B: 59868-79-0
1,3-dihydroisobenzofuran-1-ol

C: 85-44-9
phthalic anhydride

D: 643-79-8
o-phthalic dicarboxaldehyde

Conditions

Conditions	Yield
Stage #1: 1,3-dihydroisobenzofuran With N-hydroxyphthalimide; 2,2'-azobis(isobutyronitrile); oxygen In acetonitrile at 75℃; under 760.051 Torr; for 20h; Stage #2: With triphenylphosphine In acetonitrile at 25℃; Further stages.;	A 14% B 29% C 1% D 34%

...Expand

: C30H22O2

A: 796-30-5
1,4-diphenylnaphthalene

B: 643-79-8
o-phthalic dicarboxaldehyde

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In toluene at 80℃; for 1.5h;	A 33% B 33%

: 64-18-6
formic acid

: 615-42-9
1,2-Diiodobenzene

: 643-79-8
o-phthalic dicarboxaldehyde

Conditions

Conditions	Yield
With iodine; triethylamine; triphenylphosphine In toluene at 80℃; for 6h; Sealed tube; Inert atmosphere;	12%
With iodine; triethylamine; triphenylphosphine In toluene at 80℃; for 4h; Sealed tube;	11%

: 643-79-8
o-phthalic dicarboxaldehyde

: 87-41-2
2-benzofuran-1(3H)-one

Conditions

Conditions	Yield
With calcium oxide In benzene at 39.84℃; for 0.25h; Tishchenko reaction;	100%
[La2(tBu2pz)6] In benzene-d6 at 21℃; Tishchenko reaction;	100%
With [(ImDippN)Th{N(SiMe3)2}3] In benzene-d6 at 20℃; for 6h;	100%

: 39199-23-0
bis-1,3-dithiomethyl acetone

: 643-79-8
o-phthalic dicarboxaldehyde

: 6,8-Bis(methylthio)-7H-benzocyclohepten-7-on

Conditions

Conditions	Yield
With triethylamine In methanol Ambient temperature;	100%

: 536-74-3
phenylacetylene

: 643-79-8
o-phthalic dicarboxaldehyde

: 36229-69-3
1-[2-(1-hydroxy-3-phenylprop-2-ynyl)phenyl]-3-phenylprop-2-yn-1-ol

Conditions

Conditions	Yield
Stage #1: phenylacetylene With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.5h; Inert atmosphere; Stage #2: o-phthalic dicarboxaldehyde In tetrahydrofuran; hexane at 20℃; for 2h; Inert atmosphere;	100%
Stage #1: phenylacetylene With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.0833333h; Stage #2: o-phthalic dicarboxaldehyde In tetrahydrofuran; hexane for 0.5h;	99%
Stage #1: phenylacetylene With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.0833333h; Stage #2: o-phthalic dicarboxaldehyde In tetrahydrofuran; hexane at -78 - 20℃; Further stages.;	87%

: 67-56-1
methanol

: 643-79-8
o-phthalic dicarboxaldehyde

: 1122-60-7
1-nitrocyclohexane

: 189019-65-6
1-Methoxy-3-(1-nitrocyclohexyl)-1,3-dihydroisobenzofuran

Conditions

Conditions	Yield
With sodium methylate Ambient temperature;	100%

...Expand

: 873-73-4
4-n-chlorophenylacetylene

: 643-79-8
o-phthalic dicarboxaldehyde

: 942229-68-7
C24H16O2Cl2

Conditions

Conditions	Yield
Stage #1: 4-n-chlorophenylacetylene With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.5h; Inert atmosphere; Schlenk technique; Stage #2: o-phthalic dicarboxaldehyde In tetrahydrofuran; hexane at 20℃; for 2h; Inert atmosphere; Schlenk technique;	100%
Stage #1: 4-n-chlorophenylacetylene With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.0833333h; Stage #2: o-phthalic dicarboxaldehyde In tetrahydrofuran; hexane for 0.5h;	92%
Stage #1: 4-n-chlorophenylacetylene With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.0833333h; Stage #2: o-phthalic dicarboxaldehyde In tetrahydrofuran; hexane at -78 - 20℃; Further stages.;	55%
Stage #1: 4-n-chlorophenylacetylene With n-butyllithium In tetrahydrofuran at -78℃; for 0.5h; Inert atmosphere; Stage #2: o-phthalic dicarboxaldehyde In tetrahydrofuran at 20℃; for 1.5h;
Stage #1: 4-n-chlorophenylacetylene With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.5h; Inert atmosphere; Schlenk technique; Sealed tube; Stage #2: o-phthalic dicarboxaldehyde In tetrahydrofuran; hexane at 20℃; for 1.5h; Inert atmosphere; Schlenk technique; Sealed tube;

: 768-60-5
4-methoxyphenylacetylen

: 643-79-8
o-phthalic dicarboxaldehyde

: 1,1'-(1,2-phenylene)bis(3-(4-methoxyphenyl)prop-2-yn-1-ol)

Conditions

Conditions	Yield
Stage #1: 4-methoxyphenylacetylen With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.5h; Inert atmosphere; Schlenk technique; Stage #2: o-phthalic dicarboxaldehyde In tetrahydrofuran; hexane at 20℃; for 1.5h; Inert atmosphere; Schlenk technique;	100%
Stage #1: 4-methoxyphenylacetylen With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.0833333h; Stage #2: o-phthalic dicarboxaldehyde In tetrahydrofuran; hexane for 0.5h;	98%
Stage #1: 4-methoxyphenylacetylen With n-butyllithium In tetrahydrofuran at -78℃; for 0.5h; Inert atmosphere; Stage #2: o-phthalic dicarboxaldehyde In tetrahydrofuran at 20℃; for 1.5h;
Stage #1: 4-methoxyphenylacetylen With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.5h; Inert atmosphere; Schlenk technique; Sealed tube; Stage #2: o-phthalic dicarboxaldehyde In tetrahydrofuran; hexane at 20℃; for 1.5h; Inert atmosphere; Schlenk technique; Sealed tube;

: 705-31-7
4-trifluoromethylphenylacetylene

: 643-79-8
o-phthalic dicarboxaldehyde

: 1415646-42-2
1,1'-(1,2-phenylene)bis(3-(4-(trifluoromethyl)phenyl)prop-2-yn-1-ol)

Conditions

Conditions	Yield
Stage #1: 4-trifluoromethylphenylacetylene With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.5h; Inert atmosphere; Schlenk technique; Stage #2: o-phthalic dicarboxaldehyde In tetrahydrofuran; hexane at 20℃; for 1.5h; Inert atmosphere; Schlenk technique;	100%
Stage #1: 4-trifluoromethylphenylacetylene With n-butyllithium In tetrahydrofuran at -78℃; for 0.5h; Inert atmosphere; Stage #2: o-phthalic dicarboxaldehyde In tetrahydrofuran at 20℃; for 1.5h;

: potassium cyanide

: 95-55-6
2-amino-phenol

: 643-79-8
o-phthalic dicarboxaldehyde

: 2-(2-hydroxyphenyl)-2H-isoindole-1-carbonitrile

Conditions

Conditions	Yield
Stage #1: 2-amino-phenol; o-phthalic dicarboxaldehyde With sodium hydrogensulfite In water at 40℃; for 0.5h; Stage #2: potassium cyanide In water at 40℃; for 1.5h;	100%

...Expand

: 2949-26-0
2-ethynylnaphthalene

: 643-79-8
o-phthalic dicarboxaldehyde

: C32H22O2

Conditions

Conditions	Yield
Stage #1: 2-ethynylnaphthalene With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.0833333h; Stage #2: o-phthalic dicarboxaldehyde In tetrahydrofuran; hexane for 0.5h;	100%

: 15727-65-8
1-ethynylnaphthalene

: 643-79-8
o-phthalic dicarboxaldehyde

: 1-[2-(1-hydroxy-3-naphthalen-1-ylprop-2-ynyl)phenyl]-3-naphthalen-1-ylprop-2-yn-1-ol

Conditions

Conditions	Yield
Stage #1: 1-ethynylnaphthalene With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.0833333h; Stage #2: o-phthalic dicarboxaldehyde In tetrahydrofuran; hexane for 0.5h;	100%

: 33513-55-2
3-methoxy-2-oxopropylidenetriphenylphosphorane

: 643-79-8
o-phthalic dicarboxaldehyde

: 75522-06-4
1,2-bis(4-methoxy-3-oxo-1-trans-butenyl)benzene

Conditions

Conditions	Yield
In dichloromethane 1.) 15-16 deg C 15 min; 2.) refluxed for 20 h;	99.5%

: 622-88-8
4-bromophenylhydrazine hydrochloride

: 643-79-8
o-phthalic dicarboxaldehyde

: 113386-48-4
2-(4-Bromo-phenyl)-1,2-dihydro-phthalazin-1-ol

Conditions

Conditions	Yield
With sodium hydroxide In water for 2h;	99%

: 643-79-8
o-phthalic dicarboxaldehyde

: 253-52-1
PHTHALAZINE

Conditions

Conditions	Yield
With hydrazine hydrate In ethanol 1.) 0 deg C, 1 h, 2.) r.t., 2 h,;	99%
With hydrogenchloride; neodymium(II) diiodide; nitrogen In water; toluene at 70℃; under 1500.15 Torr; for 12h; Inert atmosphere;	48%

: 643-79-8
o-phthalic dicarboxaldehyde

: 766-97-2
4-n-methylphenylacetylene

: 36229-70-6
o-Bis-(1-hydroxy-3-p-tolylprop-2-inyl)-benzol

Conditions

Conditions	Yield
Stage #1: 4-n-methylphenylacetylene With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.0833333h; Stage #2: o-phthalic dicarboxaldehyde In tetrahydrofuran; hexane for 0.5h;	99%
(i) EtMgBr, THF, (ii) /BRN= 878317/; Multistep reaction;
Stage #1: 4-n-methylphenylacetylene With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.5h; Inert atmosphere; Stage #2: o-phthalic dicarboxaldehyde In tetrahydrofuran; hexane for 1.5h; Inert atmosphere;
Stage #1: 4-n-methylphenylacetylene With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.5h; Inert atmosphere; Schlenk technique; Sealed tube; Stage #2: o-phthalic dicarboxaldehyde In tetrahydrofuran; hexane at 20℃; for 1.5h; Inert atmosphere; Schlenk technique; Sealed tube;

: 68737-65-5
(R,R)-N,N'-dimethyl-1,2-diaminocyclohexane

: 643-79-8
o-phthalic dicarboxaldehyde

: 891271-46-8
(+)-(3aR,7aR)-octahydro-2-(2-((3aR,7aR)-octahydro-1,3-dimethyl-1H-benzo[d]imidazol-2-yl)phenyl)-1,3-dimethyl-1H-benzo[d]imidazole

Conditions

Conditions	Yield
at 120℃; for 16h;	99%

: [(ImDippN)Th{N(SiMe3)2}3]

: 643-79-8
o-phthalic dicarboxaldehyde

: 3-(bis-(trimethylsilyl)amino)isobenzofuran-1(3H)-one

Conditions

Conditions	Yield
In benzene-d6 for 3h;	99%

: 70-55-3
toluene-4-sulfonamide

: 187661-86-5
buta-2,3-dienoic acid benzyl ester

: 643-79-8
o-phthalic dicarboxaldehyde

: benzyl 3-((4-methylphenylsulfonamido)methyl)-2-naphthoate

Conditions

Conditions	Yield
With triphenylphosphine In acetonitrile at 0℃; Inert atmosphere;	99%

...Expand

: 14369-81-4
ethyl 2,3-butadienoate

: 643-79-8
o-phthalic dicarboxaldehyde

: 108-95-2
phenol

: ethyl 3-(phenoxymethyl)-2-naphthoate

Conditions

Conditions	Yield
With triphenylphosphine In acetonitrile at 0℃; Solvent; Temperature; Reagent/catalyst; Inert atmosphere;	99%

...Expand

: 56439-05-5, 78655-01-3, 942982-34-5
4,13-diamino<2.2>paracyclophane + 4,15-diamino<2.2>paracyclophane

: 643-79-8
o-phthalic dicarboxaldehyde

: C24H20N2

Conditions

Conditions	Yield
In ethanol for 18h; Reflux;	99%

: 617-86-7
triethylsilane

: 643-79-8
o-phthalic dicarboxaldehyde

: 18724-46-4
1,2-bis(((triethylsilyl)oxy)methyl)benzene

Conditions

Conditions	Yield
Stage #1: o-phthalic dicarboxaldehyde With C8H10BiCl2N; C4H6AgN2(1+)*C24H12BCl8(1-) In dichloromethane-d2 at 25℃; Stage #2: triethylsilane In dichloromethane at 25℃;	99%

: 75-03-6
ethyl iodide

: 643-79-8
o-phthalic dicarboxaldehyde

: 196871-46-2
1,2-bis-(1-hydroxy-propyl)-benzene

Conditions

Conditions	Yield
With magnesium In diethyl ether for 1h; Heating;	98%

: 5790-69-2
2-amino-5-chlorobenzenesulfonamide

: 643-79-8
o-phthalic dicarboxaldehyde

: 3-Chloro-11H-isoindolo<1,2-c><1,2,4>benzothiadiazine 5,5-dioxide

Conditions

Conditions	Yield
With hydrogenchloride In methanol at 20℃; for 24h;	98%

: 67-56-1
methanol

: 643-79-8
o-phthalic dicarboxaldehyde

: 2562-38-1
nitrocyclopentane

: 189019-67-8
1-Methoxy-3-(1-nitrocyclopentyl)-1,3-dihydroisobenzofuran

Conditions

Conditions	Yield
With sodium methylate Ambient temperature;	98%

...Expand

: 643-79-8
o-phthalic dicarboxaldehyde

: 612-14-6
phthalyl alcohol

Conditions

Conditions	Yield
With sodium tetrahydroborate; sodium hydrogen sulfate In acetonitrile at 20℃; for 0.0333333h;	98%
With sodium tetrahydroborate; water; titanium(IV) oxide In acetonitrile at 20℃; for 0.0833333h; regioselective reaction;	97%
With sodium tetrahydroborate; TiO(acac)2 In acetonitrile at 20℃; for 0.0333333h;	96%

: 489-84-9
7-isopropyl-1,4-dimethyl-azulene

: 643-79-8
o-phthalic dicarboxaldehyde

: 1,2-phenylenebis(3-guaiazulenylmethylium) bis(hexafluorophosphate)

Conditions

Conditions	Yield
In diethyl ether; acetonitrile at 25℃;	98%
With hexafluorophosphoric acid In water; acetic acid at 25℃; for 2h;	88%

: 70403-69-9
5-piperidin-1-yl-pentylamine

: 143-33-9
sodium cyanide

: 643-79-8
o-phthalic dicarboxaldehyde

: 2-(5-piperidin-1-yl-pentyl)-2H-isoindole-1-carbonitrile

Conditions

Conditions	Yield
With sodium tetrahydroborate In methanol at 20℃; for 18h;	98%

...Expand

: 911286-46-9
(Z)-4-(triethylsilyloxy)-1-(trimethylsilyl)non-1-ene

: 643-79-8
o-phthalic dicarboxaldehyde

: cis-2-(6-pentyl-5,6-dihydro-2H-pyran-2-yl)benzaldehyde

Conditions

Conditions	Yield
bismuth(III) bromide In dichloromethane at 20℃; for 12h;	98%

: 99-88-7
4-Isopropylaniline

: 643-79-8
o-phthalic dicarboxaldehyde

: 1093076-04-0
1-p-isopropylphenylimino-2-p-isopropylphenylisoindoline

Conditions

Conditions	Yield
With formic acid In diethyl ether at 20℃; for 12h; Inert atmosphere;	98%

: 861251-81-2
4-furan-2-yl-4-oxo-but-2-enoic acid ethyl ester

: 643-79-8
o-phthalic dicarboxaldehyde

: ethyl 2-(2-(furan-2-yl)-2-oxoethyl)-1-hydroxy-3-oxo-2,3-dihydro-1H-indene-2-carboxylate

Conditions

Conditions	Yield
With C12H14NO2S(1+)*Cl(1-); caesium carbonate In tetrahydrofuran at 20℃; Inert atmosphere; diastereoselective reaction;	98%

: 2200-53-5
penta-3,4-dien-2-one

: 643-79-8
o-phthalic dicarboxaldehyde

: 108-95-2
phenol

: 1-(3-(phenoxymethyl)naphthalen-2-yl)ethanone

Conditions

Conditions	Yield
With triphenylphosphine In acetonitrile at 0℃; Inert atmosphere;	98%

...Expand

o-Phthalaldehyde Chemical Properties

Molecular Structure:

Molecular Formula: C₈H₆O₂
Molecular Weight: 134.132
IUPAC Name: Phthalaldehyde
Synonyms of Phthalaldehyde (CAS NO.643-79-8): 4-07-00-02138 (Beilstein Handbook Reference) ; BRN 0878317 ; EINECS 211-402-2 ; NSC 13394 ; Phtalaldehydes ; Phtalaldehydes [French] ; Phthalic aldehyde ; Phthalic dialdehyde ; Phthalyldicarboxaldehyde ; UNII-4P8QP9768A ; o-Phthalaldehyde ; o-Phthaldialdehyde ; 1,2-Benzenedicarboxaldehyde
CAS NO: 643-79-8
Classification Code: Anti-Infective Agents ; Disinfectants ; Enzyme inhibitors ; Indicators and reagents
Melting point: 55-58 °C
Polar Surface Area: 34.14 Å²
Index of Refraction: 1.622
Molar Refractivity: 39.75 cm³
Molar Volume: 112.7 cm³
Surface Tension: 48.3 dyne/cm
Density: 1.189 g/cm³
Flash Point: 98.5 °C
Enthalpy of Vaporization: 50.41 kJ/mol
Boiling Point: 266.1 °C at 760 mmHg
Vapour Pressure: 0.0088 mmHg at 25°C
Form: powder
Color: yellow
Water: Solubility soluble
Sensitive: Air Sensitive
Merck: 7368
BRN: 878317
Stability: Stable. Air sensitive. Incompatible with strong oxidizing agents, strong bases.

o-Phthalaldehyde Uses

Phthalaldehyde (CAS NO.643-79-8) is pharmaceutical intermediate, and it is used in pharmaceutical inspection. It is mainly used in medicine, dyestuff, etc. It is commonly used as a high-level disinfectant for medical instruments.

o-Phthalaldehyde Production

There are two synthesis method of Phthalaldehyde (CAS NO.643-79-8): the first described in 1887 when it was prepared from α,α,α',α’-tetrachloro-ortho-xylene. And the second that hydrolysis of the related tetrabromoxylene using potassium oxalate, followed by purification by steam distillation.

o-Phthalaldehyde Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LDLo	unreported	7mg/kg (7mg/kg)		Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. Vol. 246, Pg. 851, 1958.

o-Phthalaldehyde Consensus Reports

Reported in EPA TSCA Inventory.

o-Phthalaldehyde Safety Profile

Poison by an unspecified route. When heated to decomposition it emits acrid smoke and irritating fumes. See also ALDEHYDES.
Hazard Codes of Phthalaldehyde (CAS NO.643-79-8): Xi,T,N
Risk Statements: 36/37/38-43-34-25-50
36/37/38: Irritating to eyes, respiratory system and skin
43: May cause sensitization by skin contact
34: Causes burns
25: Toxic if swallowed
50: Very Toxic to aquatic organisms
Safety Statements: 26-28-36-45-36/37/39-61-37/39
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
36/37/39: Wear suitable protective clothing, gloves and eye/face protection
61: Avoid release to the environment. Refer to special instructions safety data sheet
37/39: Wear suitable gloves and eye/face protection
RIDADR: UN2923 8/PG 2
WGK Germany: 3
RTECS: TH6950000
F: 1-8-10: Sensitive to air and humidity. Photosensitive. Keep under argon.
Hazard Note: Irritant/Air Sensitive
HS Code: 29122900

Product Name

o-Phthalaldehyde

Synthetic route

o-Phthalaldehyde Chemical Properties

o-Phthalaldehyde Uses

o-Phthalaldehyde Production

o-Phthalaldehyde Toxicity Data With Reference

o-Phthalaldehyde Consensus Reports

o-Phthalaldehyde Safety Profile

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