Product Name

  • Name

    P-TOLUENESULFINIC ACID

  • EINECS 208-638-3
  • CAS No. 536-57-2
  • Article Data206
  • CAS DataBase
  • Density 1.36 g/cm3
  • Solubility
  • Melting Point 85°
  • Formula C7H8 O2 S
  • Boiling Point 340 °C at 760 mmHg
  • Molecular Weight 156.205
  • Flash Point 159.4 °C
  • Transport Information
  • Appearance White crystal
  • Safety
  • Risk Codes
  • Molecular Structure Molecular Structure of 536-57-2 (P-TOLUENESULFINIC ACID)
  • Hazard Symbols
  • Synonyms p-Toluenesulfinicacid (6CI,8CI);4-Methylbenzenesulfinic acid;4-Toluenesulfinic acid;p-Methylbenzenesulfinic acid;p-Methylphenylsulfinic acid;p-Tolylsulfinic acid;
  • PSA 56.51000
  • LogP 2.44130

Synthetic route

sodium 4-methylbenzenesulfinate
824-79-3

sodium 4-methylbenzenesulfinate

p-toluene sulfinic acid
536-57-2

p-toluene sulfinic acid

Conditions
ConditionsYield
With hydrogenchloride In tert-butyl methyl ether; water for 0.166667h;100%
With hydrogenchloride In tert-butyl methyl ether; water for 0.166667h;100%
With hydrogenchloride In tert-butyl methyl ether; water Inert atmosphere; Schlenk technique;97%
2-p-Toluenesulfonamido-1,2,3,4-tetrahydroisoquinoline
19350-92-6

2-p-Toluenesulfonamido-1,2,3,4-tetrahydroisoquinoline

A

p-toluene sulfinic acid
536-57-2

p-toluene sulfinic acid

B

5,6,8,8a,13,14,16,16a-octahydro-s-tetrazine<6,1-a:3,4-a'>diisoquinoline
75615-02-0

5,6,8,8a,13,14,16,16a-octahydro-s-tetrazine<6,1-a:3,4-a'>diisoquinoline

Conditions
ConditionsYield
With sodium hydroxide at 80 - 90℃; for 2h;A 77%
B 99%
p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

p-toluene sulfinic acid
536-57-2

p-toluene sulfinic acid

Conditions
ConditionsYield
With lithium amalgam In isopropyl alcohol; toluene at 23℃; for 2h;98%
With tributylstibine for 0.5h; Ambient temperature;98%
With sodium sulfite In water at 80℃; for 5h;97.79%
pyridine
110-86-1

pyridine

(3-Chloro-quinoxalin-2-yl)-(toluene-4-sulfonyl)-acetonitrile
121512-59-2

(3-Chloro-quinoxalin-2-yl)-(toluene-4-sulfonyl)-acetonitrile

A

p-toluene sulfinic acid
536-57-2

p-toluene sulfinic acid

B

12-cyanoindolizino<2,3-b>quinoxaline
10176-29-1

12-cyanoindolizino<2,3-b>quinoxaline

Conditions
ConditionsYield
for 2h; Mechanism; Heating; other α-substituted 2-(3-chloro)quinoxalylacetonitrile, var. azines;A n/a
B 98%
4,8-Dimethyl-2-p-tolylsulfonyl-3(Z),7-nonadienoic acid
95682-08-9

4,8-Dimethyl-2-p-tolylsulfonyl-3(Z),7-nonadienoic acid

A

p-toluene sulfinic acid
536-57-2

p-toluene sulfinic acid

B

(3Z)‐4,8‐dimethylnona‐3,7‐dienoic acid
53668-11-4

(3Z)‐4,8‐dimethylnona‐3,7‐dienoic acid

Conditions
ConditionsYield
With sodium amalgam In methanol at 0℃; for 4.25h;A n/a
B 96%
toluene
108-88-3

toluene

p-toluene sulfinic acid
536-57-2

p-toluene sulfinic acid

Conditions
ConditionsYield
With aluminium(III) triflate; trifluorormethanesulfonic acid; sulfur dioxide; aluminium trifluoroacetate; trifluoroacetic acid at 25℃; under 760.051 Torr; for 24h; Temperature;95%
With aluminium trichloride; sulfur dioxide Zersetzen des Reaktionsproduktes mit Wasser und Salzsaeure;
With carbon disulfide; aluminium trichloride at -10℃; Man leitet einige Minuten Chlorwasserstoff und dann zwei Stunden Schwefeldioxyd ein, giesst nach 12 Stdn. auf Eis und macht mit Soda alkalisch;
With aluminium trichloride; sulfuryl dichloride
4-methylbenzenesulfonic acid n-hexylester
3839-35-8

4-methylbenzenesulfonic acid n-hexylester

A

p-toluene sulfinic acid
536-57-2

p-toluene sulfinic acid

B

hexan-1-ol
111-27-3

hexan-1-ol

Conditions
ConditionsYield
With lithium amalgam In 1,4-dioxane; isopropyl alcohol at 23℃; for 2h;A 95%
B 95%
3-(tosylmethyl)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one

3-(tosylmethyl)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one

A

p-toluene sulfinic acid
536-57-2

p-toluene sulfinic acid

B

3-methylene-9-oxo-1,2,3,9-tetrahydropyrrolo<2,1-b>quinazoline
98262-85-2

3-methylene-9-oxo-1,2,3,9-tetrahydropyrrolo<2,1-b>quinazoline

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In chloroform Inert atmosphere;A n/a
B 95%

A

p-toluene sulfinic acid
536-57-2

p-toluene sulfinic acid

B

7,7-dimethoxybicyclo<2.2.1>heptane
39869-70-0

7,7-dimethoxybicyclo<2.2.1>heptane

Conditions
ConditionsYield
With diisobutylaluminium hydride In hexane at 0℃; for 0.25h;A 90%
B 66%
N-methyl-N-(2-phenethyl)-4-methylbenzenesulfonamide
25566-59-0

N-methyl-N-(2-phenethyl)-4-methylbenzenesulfonamide

A

p-toluene sulfinic acid
536-57-2

p-toluene sulfinic acid

C

methyl p-toluene sulfinate
672-78-6

methyl p-toluene sulfinate

D

N-Methyl-N-phenethylamine
589-08-2

N-Methyl-N-phenethylamine

Conditions
ConditionsYield
With sodium tetrahydroborate; 1,5-dimethoxynaphthalene In ethanol Irradiation;A 71%
B n/a
C n/a
D 89%
N-cyclopropyl-N-tetradecyl-4-methylbenzenesulfonamide

N-cyclopropyl-N-tetradecyl-4-methylbenzenesulfonamide

A

p-toluene sulfinic acid
536-57-2

p-toluene sulfinic acid

B

tetradecylamine
2016-42-4

tetradecylamine

Conditions
ConditionsYield
With N1,N1,N12,N12-tetramethyl-7,8-dihydro-6H-dipyrido[1,2-a:2,1'-c][1,4]diazepine-2,12-diamine In N,N-dimethyl-formamide for 72h; UV-irradiation;A 78%
B 85%
sodium p-toluenesulfinate tetrahydrate
7257-26-3

sodium p-toluenesulfinate tetrahydrate

p-toluene sulfinic acid
536-57-2

p-toluene sulfinic acid

Conditions
ConditionsYield
With hydrogenchloride; tert-butyl methyl ether In water for 0.333333h; Inert atmosphere;84%
ethyl N-[(4-methylphenyl)sulfonyl]-N-phenylglycinate
94675-53-3

ethyl N-[(4-methylphenyl)sulfonyl]-N-phenylglycinate

A

N-phenylglycine ethyl ester
2216-92-4

N-phenylglycine ethyl ester

B

p-toluene sulfinic acid
536-57-2

p-toluene sulfinic acid

Conditions
ConditionsYield
With N-Benzylaniline In N,N-dimethyl-formamide UV-irradiation;A 83%
B n/a

A

p-toluene sulfinic acid
536-57-2

p-toluene sulfinic acid

B

di(4-methyl)phenylthiosulfonate
2943-42-2

di(4-methyl)phenylthiosulfonate

Conditions
ConditionsYield
In ethanol at 90℃;A 20%
B 72%
para-thiocresol
106-45-6

para-thiocresol

p-toluene sulfinic acid
536-57-2

p-toluene sulfinic acid

Conditions
ConditionsYield
With HOF* CH3CN In methanol at -40℃;70%
With hydrogenchloride; sodium hydroxide; dihydrogen peroxide 1.)EtOH, water, rt., 10 min; 2.) water, 0 deg C; Yield given. Multistep reaction;
Multi-step reaction with 4 steps
1: 90 percent / benzene / 5 h / Heating
2: 70 percent / AcOH, 30percent H2O2 / 24 h / 25 °C
3: 85 percent / acetone / 24 h / 25 °C
4: K2CO3 / acetone; H2O / 24 h / 25 °C
View Scheme
S-(4-chlorophenyl) 4-methylbenzenesulfonothioate
28823-18-9

S-(4-chlorophenyl) 4-methylbenzenesulfonothioate

sodium salt of triacetic acid lactone
30536-52-8

sodium salt of triacetic acid lactone

A

p-toluene sulfinic acid
536-57-2

p-toluene sulfinic acid

B

3-p-Chlorophenylthio-4-hydroxy-6-methyl-2-pyrone
53603-22-8

3-p-Chlorophenylthio-4-hydroxy-6-methyl-2-pyrone

Conditions
ConditionsYield
In ethanolA 70%
B n/a
benzyl tosylate
1024-41-5

benzyl tosylate

sodium salt of triacetic acid lactone
30536-52-8

sodium salt of triacetic acid lactone

A

p-toluene sulfinic acid
536-57-2

p-toluene sulfinic acid

B

3-Benzylthio-4-hydroxy-6-methyl-2-pyrone
53603-23-9

3-Benzylthio-4-hydroxy-6-methyl-2-pyrone

Conditions
ConditionsYield
In ethanolA n/a
B 66%
methyl thiotosylate
4973-66-4

methyl thiotosylate

sodium salt of triacetic acid lactone
30536-52-8

sodium salt of triacetic acid lactone

A

p-toluene sulfinic acid
536-57-2

p-toluene sulfinic acid

B

4-Hydroxy-6-methyl-3-methylthio-2-pyrone

4-Hydroxy-6-methyl-3-methylthio-2-pyrone

Conditions
ConditionsYield
In ethanolA n/a
B 64%
N-phenyl N-(4-methylphenylsulfonyl) hydroxylamine
38557-76-5

N-phenyl N-(4-methylphenylsulfonyl) hydroxylamine

p-toluene sulfinic acid
536-57-2

p-toluene sulfinic acid

Conditions
ConditionsYield
With sodium hydroxide In diethyl ether63%
4-methyl-benzaldehyde
104-87-0

4-methyl-benzaldehyde

S-benzyl 4-methylbenzenethiosulfonate
16601-02-8

S-benzyl 4-methylbenzenethiosulfonate

p-toluene sulfinic acid
536-57-2

p-toluene sulfinic acid

Conditions
ConditionsYield
With sodium carbonate; 9,10-phenanthrenequinone In acetonitrile at 20℃; for 14h; Schlenk technique; Sealed tube; Irradiation;61%
fluorenone tosylhydrazone anion

fluorenone tosylhydrazone anion

A

p-toluene sulfinic acid
536-57-2

p-toluene sulfinic acid

B

fluorenone imine
4440-33-9

fluorenone imine

C

9-aminofluorene
525-03-1

9-aminofluorene

D

N'-(9H-fluoren-9-ylidene)-4-methylbenzenesulfonohydrazide
52341-51-2

N'-(9H-fluoren-9-ylidene)-4-methylbenzenesulfonohydrazide

E

toluene-4-sulfonamide
70-55-3

toluene-4-sulfonamide

F

fluoren-9-ylidene-hydrazine
13629-22-6

fluoren-9-ylidene-hydrazine

Conditions
ConditionsYield
With tetrabutylammonium perchlorate In N,N-dimethyl-formamide at 22℃; Product distribution; electrolytic reduction at a platinum gauze electrode; also addition of proton donors;A 4%
B 6%
C 41%
D 60%
E 37%
F 2.6%
1,1’-[(Z)-ethene-1,2-diyldisulfonyl]bis(4-methylbenzene)
15645-75-7

1,1’-[(Z)-ethene-1,2-diyldisulfonyl]bis(4-methylbenzene)

2-diazopropane
2684-60-8

2-diazopropane

A

p-toluene sulfinic acid
536-57-2

p-toluene sulfinic acid

B

1-methyl-4-(propane-2-sulfonyl)benzene
51751-71-4, 20288-47-5

1-methyl-4-(propane-2-sulfonyl)benzene

3,3a,6,6a-tetrahydro-3,3,6,6-tetramethyl-3a-(p-tolylsulfonyl)pyrazolo<4,3-c>pyrazole
128641-83-8, 137305-78-3

3,3a,6,6a-tetrahydro-3,3,6,6-tetramethyl-3a-(p-tolylsulfonyl)pyrazolo<4,3-c>pyrazole

Conditions
ConditionsYield
In methanol 1) -78 deg C, to RT, 12 h;A n/a
B 2.4 g
C 50%
4-tolyl iodide
624-31-7

4-tolyl iodide

A

p-toluene sulfinic acid
536-57-2

p-toluene sulfinic acid

B

C7H8(18)O2S

C7H8(18)O2S

C

C7H8O(18)OS

C7H8O(18)OS

Conditions
ConditionsYield
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate; Aminoiminomethanesulfinic acid; 18O-labeled water In dimethyl sulfoxide at 100℃; for 2h; Inert atmosphere;A 19%
B 30%
C 40%
2-bromo-6-(2,2,6,6-tetramethyltetrahydro-pyran-4-yl)pyridin-3-ylamine
1142363-62-9

2-bromo-6-(2,2,6,6-tetramethyltetrahydro-pyran-4-yl)pyridin-3-ylamine

N'-(4,4-dimethylcyclohexylidene)-4-methylbenzene-1-sulfonohydrazide
64692-81-5

N'-(4,4-dimethylcyclohexylidene)-4-methylbenzene-1-sulfonohydrazide

A

p-toluene sulfinic acid
536-57-2

p-toluene sulfinic acid

B

6-(2,2,6,6-tetramethyl-tetrahydro-pyran-4-yl)-pyridin-3-ylamine
1142363-60-7

6-(2,2,6,6-tetramethyl-tetrahydro-pyran-4-yl)-pyridin-3-ylamine

C

C28H42N4O2

C28H42N4O2

D

C15H22O2S

C15H22O2S

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); lithium tert-butoxide; XPhos In 1,4-dioxane at 110℃; Inert atmosphere;A n/a
B 19%
C 30%
D n/a
5-p-chlorophenyl-2-phenyl-4-tosyl-2-oxazoline
80225-01-0

5-p-chlorophenyl-2-phenyl-4-tosyl-2-oxazoline

A

4-chlorophenylacetic Acid
1878-66-6

4-chlorophenylacetic Acid

B

5-(4-chlorophenyl)-2-phenyl-1,3-oxazole
80224-89-1

5-(4-chlorophenyl)-2-phenyl-1,3-oxazole

C

p-toluene sulfinic acid
536-57-2

p-toluene sulfinic acid

D

benzamide
55-21-0

benzamide

Conditions
ConditionsYield
With potassium carbonate In methanol for 1.5h; Heating; Yields of byproduct given;A n/a
B 14%
C n/a
D n/a
diethyl ether
60-29-7

diethyl ether

p-toluenesulfonyl iodide
1950-78-3

p-toluenesulfonyl iodide

phenylmagnesium bromide

phenylmagnesium bromide

A

p-toluene sulfinic acid
536-57-2

p-toluene sulfinic acid

B

iodobenzene
591-50-4

iodobenzene

diethyl ether
60-29-7

diethyl ether

toluene-p-sulfonyl bromide
1950-69-2

toluene-p-sulfonyl bromide

phenylmagnesium bromide

phenylmagnesium bromide

A

p-toluene sulfinic acid
536-57-2

p-toluene sulfinic acid

B

bromobenzene
108-86-1

bromobenzene

ethanol
64-17-5

ethanol

2-nitrothiophenol
4875-10-9

2-nitrothiophenol

S-(2-nitrophenyl) 4-toluenethiosulfonate
34158-66-2

S-(2-nitrophenyl) 4-toluenethiosulfonate

A

bis(2-nitrophenyl)disulfide
1155-00-6

bis(2-nitrophenyl)disulfide

B

p-toluene sulfinic acid
536-57-2

p-toluene sulfinic acid

ethanol
64-17-5

ethanol

2,5-dichlorbenzenethiol
5858-18-4

2,5-dichlorbenzenethiol

di(4-methyl)phenylthiosulfonate
2943-42-2

di(4-methyl)phenylthiosulfonate

A

p-toluene sulfinic acid
536-57-2

p-toluene sulfinic acid

B

(2,5-dichloro-phenyl)-p-tolyl disulfide

(2,5-dichloro-phenyl)-p-tolyl disulfide

Conditions
ConditionsYield
reagiert analog mit p-Tolylmercaptan und mit Anthranylmercaptan;
p-toluene sulfinic acid
536-57-2

p-toluene sulfinic acid

4-methylbenzenesulfinyl chloride
10439-23-3

4-methylbenzenesulfinyl chloride

Conditions
ConditionsYield
With thionyl chloride In diethyl ether at 0 - 40℃; for 4h;100%
With thionyl chloride
With thionyl chloride
p-toluene sulfinic acid
536-57-2

p-toluene sulfinic acid

benzeneseleninic acid
6996-92-5

benzeneseleninic acid

C7H8O3S*C6H6O2Se
76200-60-7

C7H8O3S*C6H6O2Se

Conditions
ConditionsYield
In acetonitrile at 0℃; for 1h;100%
p-toluene sulfinic acid
536-57-2

p-toluene sulfinic acid

trans-3,6-dimethyl-4-hydroxyhexahydropyrimidine-2-thione
27406-58-2, 97481-94-2, 97481-95-3

trans-3,6-dimethyl-4-hydroxyhexahydropyrimidine-2-thione

(4R,6R)-1,4-Dimethyl-6-(toluene-4-sulfonyl)-tetrahydro-pyrimidine-2-thione
134982-80-2

(4R,6R)-1,4-Dimethyl-6-(toluene-4-sulfonyl)-tetrahydro-pyrimidine-2-thione

Conditions
ConditionsYield
In water at 20℃;100%
p-toluene sulfinic acid
536-57-2

p-toluene sulfinic acid

1-[(R)-1-(2,6-Dichloro-phenyl)-ethyl]-5-hydroxy-pyrrolidin-2-one
126017-80-9

1-[(R)-1-(2,6-Dichloro-phenyl)-ethyl]-5-hydroxy-pyrrolidin-2-one

(5R)-(-)-<(1R)-1-(2,6-dichlorophenyl)ethyl>-5-(p-toluenesulfonyl)pyrrolidinone
134457-72-0

(5R)-(-)-<(1R)-1-(2,6-dichlorophenyl)ethyl>-5-(p-toluenesulfonyl)pyrrolidinone

Conditions
ConditionsYield
In dichloromethane for 2h;100%
4,5-dihydroxy-2-imidazolidinone
3720-97-6

4,5-dihydroxy-2-imidazolidinone

p-toluene sulfinic acid
536-57-2

p-toluene sulfinic acid

4-(p-tolylsulfonyl)-2-imidazolinone

4-(p-tolylsulfonyl)-2-imidazolinone

Conditions
ConditionsYield
In water for 0.75h; Heating;99.9%
p-toluene sulfinic acid
536-57-2

p-toluene sulfinic acid

(-)-menthol
2216-51-5

(-)-menthol

(-)-menthyl p-toluenesulfinate
1517-82-4

(-)-menthyl p-toluenesulfinate

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 25℃; for 16h; Temperature; Reagent/catalyst; Inert atmosphere;99%
With pyridine; chlorophosphoric acid diphenyl ester In dichloromethane for 15h; Product distribution; Ambient temperature; variation of reagents, temperature and reaction time;95%
With pyridine; chlorophosphoric acid diphenyl ester In dichloromethane for 15h; Ambient temperature;95%
p-toluene sulfinic acid
536-57-2

p-toluene sulfinic acid

benzaldehyde
100-52-7

benzaldehyde

N-[(4-methylbenzene-1-sulfonyl)(phenyl)methyl]formamide
37643-54-2

N-[(4-methylbenzene-1-sulfonyl)(phenyl)methyl]formamide

Conditions
ConditionsYield
Stage #1: benzaldehyde; formamide With chloro-trimethyl-silane In toluene; acetonitrile at 55℃; for 3h; Inert atmosphere; Schlenk technique;
Stage #2: p-toluene sulfinic acid In toluene; acetonitrile Inert atmosphere; Schlenk technique;
99%
With chloro-trimethyl-silane In toluene; acetonitrile at 50℃; for 5h;94%
With (R)-10-camphorsulfonic acid at 60℃; for 18h;82%
p-toluene sulfinic acid
536-57-2

p-toluene sulfinic acid

aqueous alcohol

aqueous alcohol

NaH2 PO3

NaH2 PO3

1-(2,4-dichlorophenyl)-4,4-dimethylpent-1-en-3-one
58344-25-5

1-(2,4-dichlorophenyl)-4,4-dimethylpent-1-en-3-one

1-(2,4-dichlorophenyl)-1-p-toluene-sulfonyl-4,4-dimethylpentan-3-one

1-(2,4-dichlorophenyl)-1-p-toluene-sulfonyl-4,4-dimethylpentan-3-one

Conditions
ConditionsYield
With sodium hydrogencarbonate In (2S)-N-methyl-1-phenylpropan-2-amine hydrate99%
3-phenyl-propionaldehyde
104-53-0

3-phenyl-propionaldehyde

p-toluene sulfinic acid
536-57-2

p-toluene sulfinic acid

benzamide
55-21-0

benzamide

N-(1-p-toluenesulphonyl-3-phenylpropyl)benzamide
84993-37-3

N-(1-p-toluenesulphonyl-3-phenylpropyl)benzamide

Conditions
ConditionsYield
With magnesium sulfate In dichloromethane at 20℃; for 16h;99%
p-toluene sulfinic acid
536-57-2

p-toluene sulfinic acid

(Z)-4-heptenal
6728-31-0

(Z)-4-heptenal

benzamide
55-21-0

benzamide

(Z)-N-(1-tosylhept-4-enyl)benzamide
1000681-66-2

(Z)-N-(1-tosylhept-4-enyl)benzamide

Conditions
ConditionsYield
With magnesium sulfate In dichloromethane at 20℃;99%
p-toluene sulfinic acid
536-57-2

p-toluene sulfinic acid

benzyloxyacetoaldehyde
60656-87-3

benzyloxyacetoaldehyde

benzamide
55-21-0

benzamide

N-(2-(benzyloxy)-1-tosylethyl)benzamide
1000681-65-1

N-(2-(benzyloxy)-1-tosylethyl)benzamide

Conditions
ConditionsYield
With magnesium sulfate In dichloromethane at 20℃;99%
p-toluene sulfinic acid
536-57-2

p-toluene sulfinic acid

benzamide
55-21-0

benzamide

cyclohexanecarbaldehyde
2043-61-0

cyclohexanecarbaldehyde

N-(cyclohexyl(tosyl)methyl)benzamide
372199-89-8

N-(cyclohexyl(tosyl)methyl)benzamide

Conditions
ConditionsYield
With magnesium sulfate In dichloromethane at 20℃; for 16h;99%
dirhodium tetraacetate

dirhodium tetraacetate

p-toluene sulfinic acid
536-57-2

p-toluene sulfinic acid

tri(toluene-p-sulphinato)rhodium(III)

tri(toluene-p-sulphinato)rhodium(III)

Conditions
ConditionsYield
In methanol byproducts: CH3CO2H, H2; N2-atmosphere;99%
In tetrahydrofuran byproducts: CH3CO2H, H2; N2-atmosphere;99%
p-toluene sulfinic acid
536-57-2

p-toluene sulfinic acid

(E)-2-(4-methoxybenzylidene)hydrazine carboxamide
120445-53-6

(E)-2-(4-methoxybenzylidene)hydrazine carboxamide

4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

(E)-1-(4-methoxybenzylidene)-4-[(4-methoxyphenyl)(tosyl)methyl]semicarbazide

(E)-1-(4-methoxybenzylidene)-4-[(4-methoxyphenyl)(tosyl)methyl]semicarbazide

Conditions
ConditionsYield
In ethanol at 20℃; for 144h;99%
Stage #1: p-toluene sulfinic acid; 4-methoxy-benzaldehyde In ethanol at 20℃; for 0.166667h;
Stage #2: (E)-2-(4-methoxybenzylidene)hydrazine carboxamide In ethanol at 20℃; for 144h; Enzymatic reaction;
99%
p-toluene sulfinic acid
536-57-2

p-toluene sulfinic acid

methyl ethynyl ketone
1423-60-5

methyl ethynyl ketone

(Z)-4-(p-tolylsulfonyl)-3-buten-2-one
88726-08-3

(Z)-4-(p-tolylsulfonyl)-3-buten-2-one

Conditions
ConditionsYield
In ethanol at 20℃; for 40h; pH=3.5; stereoselective reaction;99%
With vanillin In ethanol at 20℃; UV-irradiation;99%
p-toluene sulfinic acid
536-57-2

p-toluene sulfinic acid

N-(3-(p-tolyl)prop-2-yn-1-yl)aniline

N-(3-(p-tolyl)prop-2-yn-1-yl)aniline

4-(p-tolyl)-3-tosylquinoline

4-(p-tolyl)-3-tosylquinoline

Conditions
ConditionsYield
With pyridine In 1,2-dichloro-ethane at 20℃; for 8h; UV-irradiation;99%
p-toluene sulfinic acid
536-57-2

p-toluene sulfinic acid

N-(3-(4-(trifluoromethyl)phenyl)prop-2-yn-1-yl)aniline

N-(3-(4-(trifluoromethyl)phenyl)prop-2-yn-1-yl)aniline

3-tosyl-4-(4-(trifluoromethyl)phenyl)quinoline

3-tosyl-4-(4-(trifluoromethyl)phenyl)quinoline

Conditions
ConditionsYield
With pyridine In 1,2-dichloro-ethane at 20℃; for 8h; UV-irradiation;99%
p-toluene sulfinic acid
536-57-2

p-toluene sulfinic acid

4-chloro-N-(3-phenylprop-2-yn-1-yl)aniline

4-chloro-N-(3-phenylprop-2-yn-1-yl)aniline

6-chloro-4-phenyl-3-tosylquinoline

6-chloro-4-phenyl-3-tosylquinoline

Conditions
ConditionsYield
With pyridine In 1,2-dichloro-ethane at 20℃; for 8h; UV-irradiation;99%
p-toluene sulfinic acid
536-57-2

p-toluene sulfinic acid

3,4-dimethoxy-benzaldehyde
120-14-9

3,4-dimethoxy-benzaldehyde

urea
57-13-6

urea

N-[(3,4-dimethoxyphenyl)(tosyl)methyl]urea

N-[(3,4-dimethoxyphenyl)(tosyl)methyl]urea

Conditions
ConditionsYield
Stage #1: p-toluene sulfinic acid; 3,4-dimethoxy-benzaldehyde In formic acid; water at 20℃; for 0.166667h;
Stage #2: urea In formic acid; water at 20℃; for 24h; Solvent;
99%
p-toluene sulfinic acid
536-57-2

p-toluene sulfinic acid

4-methoxybenzaldehyde semicarbazone
6292-71-3, 120445-53-6

4-methoxybenzaldehyde semicarbazone

4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

(E)-1-(4-methoxybenzylidene)-4-[(4-methoxyphenyl)(tosyl)methyl]semicarbazide

(E)-1-(4-methoxybenzylidene)-4-[(4-methoxyphenyl)(tosyl)methyl]semicarbazide

Conditions
ConditionsYield
Stage #1: p-toluene sulfinic acid; 4-methoxy-benzaldehyde In ethanol at 20℃;
Stage #2: 4-methoxybenzaldehyde semicarbazone In ethanol at 20℃; for 144h;
99%
vinylcaprolactam
2235-00-9

vinylcaprolactam

p-toluene sulfinic acid
536-57-2

p-toluene sulfinic acid

1-(1-tosylethyl)azepan-2-one

1-(1-tosylethyl)azepan-2-one

Conditions
ConditionsYield
With photoredox catalyst Ni/TiO2 In acetonitrile at 20℃; for 3.5h; Molecular sieve; Irradiation;99%
p-toluene sulfinic acid
536-57-2

p-toluene sulfinic acid

di(p-tolyl) disulfide
103-19-5

di(p-tolyl) disulfide

Conditions
ConditionsYield
With piperidinium thiotungstate In N,N-dimethyl-formamide for 0.5h; Ambient temperature;98%
With phosphorus; iodine; acetic acid
Electrolysis;
p-toluene sulfinic acid
536-57-2

p-toluene sulfinic acid

3-methylcyclohexen-2-one
1193-18-6

3-methylcyclohexen-2-one

3-methyl-3-((4-methylphenyl)sulfonyl)cyclohexanone
33866-94-3

3-methyl-3-((4-methylphenyl)sulfonyl)cyclohexanone

Conditions
ConditionsYield
In acetonitrile for 48h;98%
With hydrogenchloride In diethyl ether
p-toluene sulfinic acid
536-57-2

p-toluene sulfinic acid

octanol
111-87-5

octanol

octyl 4-methylbenzenesulfinate
40491-80-3

octyl 4-methylbenzenesulfinate

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide at 20℃; for 0.0666667h;98%
With pyridine; O-phenyl phosphorodichloridate In dichloromethane for 7h; Ambient temperature;84%
With thionyl chloride; silica gel at 20℃; for 0.666667h;68%
With dicyclohexyl-carbodiimide
With 2-chloro-1-methyl-pyridinium iodide; triethylamine In dichloromethane Heating;
p-toluene sulfinic acid
536-57-2

p-toluene sulfinic acid

cyclohexanol
108-93-0

cyclohexanol

cyclohexyl 4-methylbenzenesulfinate
23730-24-7

cyclohexyl 4-methylbenzenesulfinate

Conditions
ConditionsYield
With pyridine; chlorophosphoric acid diphenyl ester In dichloromethane for 15h; Product distribution; Ambient temperature; variation of reagents, temperature and reaction time;98%
With pyridine; chlorophosphoric acid diphenyl ester In dichloromethane for 15h; Ambient temperature;98%
With dicyclohexyl-carbodiimide at 20℃; for 0.166667h;90%

p-Toluenesulfinic acid Chemical Properties

IUPAC Name: 4-Methylbenzenesulfinic acid
Synonyms of p-Toluenesulfinic acid (CAS NO.536-57-2) : 4-Toluenesulfinic acid ; Benzenesulfinic acid, 4-methyl-
Product Categories: Boron, Nitrile, Thio,& TM-Cpds;Benzene derivates;Organic Building Blocks;Sulfonyl Halides;Sulfur Compounds
Product Categories:Industrial/Fine Chemicals
CAS NO:536-57-2
Molecular Formula of p-Toluenesulfinic acid (CAS NO.536-57-2) :C7H8O2S
Molecular Weight of p-Toluenesulfinic acid (CAS NO.536-57-2) :156.2
Molecular Structure of p-Toluenesulfinic acid (CAS NO.536-57-2) :
EINECS: 208-638-3
Index of Refraction:1.653
Surface Tension: 71.5 dyne/cm
Density: 1.36 g/cm3
Flash Point: 159.4 °C
Enthalpy of Vaporization: 61.59 kJ/mol
Boiling Point: 340 °C at 760 mmHg
Vapour Pressure: 3.42E-05 mmHg at 25°C  

p-Toluenesulfinic acid Uses

 p-Toluenesulfinic acid (CAS NO.536-57-2) is used as a curing agent for grouting material . 

p-Toluenesulfinic acid Safety Profile

RTECS GZ7260000

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