ADHD drug can wake up mice under general anaesthetic almost immediately

Attention-deficit/hyperactivity disorder (ADHD) is one of the most prevalent neurodevelopmental disorders, affecting approximately 7–12% of children, adolescents and adults worldwide. Up to 30% of the 6.4 million children diagnosed with ADHD will continue to meet criteria for ADHD in adulthood,...

Continuous free flow electrophoresis (CFFE) was applied to the preparative chiral separation of ritalin enantiomers. Sulfated β-cyclodextrin (sβ-CD) was used as the chiral additive. Liquid chromatography–mass spectrometry (LC–MS) experiments were applied to study the time averaged concentrat...

In debates over diagnoses of Attention Deficit/Hyperactivity Disorder (ADHD) and use of the drug Ritalin among the American school age population, discussion often centers around who is to blame for rising diagnoses and increasing use of Ritalin. Parents have come under particular scrutiny by cr...

The primary purpose of this study was to examine the extent to which two of the three sources of risk-taking—dispositional and ecological—in adolescence and demographic variables were related to Ritalin, tranquilizer and narcotics misuse. The secondary aim of this study was to distinguish subg...

Methylphenidate hydrochloride (Ritalin) is the drug of choice for attention deficit hyperactivity disorder (ADHD). However, an association of Ritalin with glaucoma has been reported. We report a case of Ritalin-associated cataract and glaucoma. A 10-year-old boy was diagnosed with ADHD and had r...

BackgroundThe stimulant drug methylphenidate, otherwise known as Ritalin, is the mainstay of treatment for Attention Deficit Hyperactivity Disorder and is the most common psychotropic medication prescribed to children. Whilst psychiatric discourse presents it as a safe and effective treatment, c...

Methylergonovine (ME) is a semisynthetic ergot alkaloid that is used for the treatment and prophylaxis of postpartum hemorrhage. In recent years, methylergonovine has been effective in the control of refractory headaches and is likely to be employed as chemosensitizers for cancer. However, this ...

ObjectiveThe purpose of this study was to examine the risks of acute coronary syndrome (ACS) and acute myocardial infarction (AMI) that are associated with methylergonovine maleate (Methergine; Novartis Pharmaceuticals Corporation, Plantation, FL) use in a large database of inpatient delivery ad...

Raynaud’s disease is a medical condition in which arterial spasm causes episodes of reduced blood flow, in the setting of certain triggers such as cold weather. Patients with this condition are at risk of adverse reactions if they receive medications with vasoactive properties. Methylergonovine...

The mRNA cap is a structure that protects mRNA from degradation and recruits processing and translation factors. A new mRNA capping enzyme has been identified, PCIF1/CAPAM, which methylates adenosine when it is the first transcribed nucleotide. This discovery is crucial for understanding the fun...

Capping and lamination are classical industrial issues that can be challenging during the scale up of solid dosage forms. Previous publications showed that changing the unloading conditions (triaxial decompression, loaded ejection) made it possible to mitigate capping. In the present study, a sy...

Capping stack is an emergency shut-in technique that can effectively control offshore blowout accidents. This technique stemmed the spilled oil well (Macondo) in 2010 Deepwater Horizon blowout accident. However, few efforts have been devoted to studying the way to efficiently and safely conduct ...

This paper analyzes the effects of a bid cap in an all-pay auction with incomplete information. I find that a non-trivial bid cap affects an agent’s expected payment in three ways: An “anti-competition effect” which is associated with this agent’s own signal, a pro-competitive “good news ef...

In this paper I analyse the behaviour of a monopoly electricity provider that serves three distinct markets under a price cap or revenue cap plan. I make comparisons in terms of their effects on price setting, energy conservation, and social welfare.In addition to contravening the Ramsey pricing...

Background and ObjectiveBrain machine interface (BMI) is a system which communicates the brain with the external machines. In general, an electroencephalograph (EEG) machine has to be used to monitor multi-channel brain responses to improve the BMI performance. However, the bulky size of the EEG...

We study the effect of rigid and flexible bid caps on contestants' aggregate costs and aggregate bids in all-pay contests with a large number of heterogeneous contestants and prizes.We show that rigid caps always decrease aggregate costs, whereas flexible caps have essentially no effect on ...

We consider a network pricing game on a parallel network with congestion effects in which link owners set tolls for travel so as to maximize profit. A central authority is able to regulate this competition by means of a (uniform) price cap. The first question we want to answer is how such a cap ...

The cap effects on the wave forces acting on the piles underneath the cap are important for the estimation of the wave loads on the elevated pile-cap foundations of sea-crossing bridges. Full scale 3-dimensional numerical simulations are carried out for large square caps with piles placed at dif...

Microbial-based chemical synthesis serves as a promising approach for sustainable production of industrially important products. However, limited production performance caused by metabolic burden or genetic variations poses one of the major challenges in achieving an economically viable biomanuf...