Dothiepin, a tricyclic antidepressant, significantly inhibited the development of gastric ulcers induced by alcohol, aspirin, indomethacin and Shay's pyloric ligation. Antisecretory studies in pyloric ligated rats revealed that the drug at a dose of 100 mg/kg significantly reduced total aci...

High pressure liquid chromatography coupled to photodiode array detector and capillary gas chromatography coupled to mass spectrometry were employed to quantify dothiepin in biological fluids, tissues and hair in a death attributed to oral dothiepin (ProthiadenR) ingestion. The blood concentrati...

Sensitive spectrophotometric and spectrofluorimetric methods are described for the determination of tramadol, acebutolol and dothiepin (dosulepin) hydrochlorides. The two methods are based on the condensation of the cited drugs with the mixed anhydrides of malonic and acetic acids at 60 °C for ...

An ingestion of an unknown quantity of Harmomed® (dothiepin and diazepam) capsules in a suicide is described. The authors report a new and fast method of analysing and determining the dothiepin concentration in postmortem specimens. Quantitation of dothiepin, and its metabolite desmethyldothiepi...

Dothiepin hydrochloride is a tricyclic antidepressant and a thio-derivative of amitriptyline. Like amitriptyline, dothiepin also has sedative properties and is used clinically to treat anxiety as well as depression.

The absorption and fluorescence spectra of dothiepin and doxepin have been recorded in solvents of different polarities and β-cyclodextrin (β-CD). The inclusion complex of both drugs with β-CD is investigated by UV–visible, fluorimetry, DFT, FT-IR and scanning electron microscopy (SEM). In a...

The aggregation behavior and interaction of an amphiphilic antidepressant drug imipramine (IMP) hydrochloride with the cationic surfactant cetyltrimethylammonium bromide (CTAB) have been studied using light scattering (both static and dynamic) techniques. Due to rigid tricyclic hydrophobic moiet...

Benzidine and o-tolidine, the hazardous carcinogens are still in use for the detection of blood in urine. Development of safer substitutes are of paramount importance. Unfortunately, the alternate available reagents lack specificity, sensitivity and reproducibility. Imipramine hydrochloride (IPH...

The effect of various additives used in pharmaceutical formulations (inorganic salts, QABs, amino acids, sugars, alcohols, ureas) has been seen by studying the clouding phenomenon of imipramine hydrochloride (IMP) drug in solution. At fixed pH values, increasing inorganic salt concentrations cau...

The clouding behavior of tricyclic antidepressant drug imipramine hydrochloride (IMP) in aqueous solution has been studied in presence of surfactants. A pH increase in the presence as well as in the absence of surfactants decreased the CP. Drug molecules become neutral at high pH and therefore h...

Herein, we have checked the interaction between the imipramine hydrochloride (IMH, an antidepressant drug) and anionic surfactant dioctyl sulfosuccinate sodium salt (AOT) mixed system through a conductometric method in aqueous medium along with electrolyte solutions at different temperatures (28...

Imipramine hydrochloride (IMP) is a drug which is amphiphilic. Its interaction with gemini surfactants 14-s-14 (s = 4, 5, 6) has been investigated at different temperatures employing conductimetric measurements. The experimentally determined critical micelle concentration (cmc) values come out t...

Imipramine hydrochloride ([H-IMI]Cl), C19H24N2.HCl, is the prototypic tricyclic antidepressant (TCA) inhibitor of norepinephrine and serotonin neuronal reuptake. The molecular structure, molecular electrostatic potential (MEP), natural bond orbital (NBO) analysis, linear and non-linear optical (...

The micellization phenomena in the mixed system of the amphiphilic antidepressant drug imipramine hydrochloride (IPH) and cationic hydrotropes - aniline hydrochloride (AnH), ortho-toluidine hydrochloride (o-ToH), as well as para-toluidine hydrochloride (p-ToH)- in a water solution at a range of ...

BackgroundPlasticizer di-2-ethylhexyl phthalate (DEHP) can induce lipid metabolic disorder. There was a chronic low level inflammatory response in adipose tissue of patients with lipid metabolic disorder. But the effect of inflammation on lipid metabolic disorder induced by DEHP is unclear. The ...

Di (2-ethylhexyl) phthalate (DEHP) and di-n-butyl phthalate (DBP) are important pollutants that contaminate agricultural soils. We determined the effects of di (2-ethylhexyl) phthalate (DEHP) and di-n-butyl phthalate (DBP) on the production of reactive oxygen species, photosynthesis, and activit...

This article presents a study on the viscous behaviour at high pressure of a synthetic oil, tris(2-ethylhexyl) trimellitate (TOTM). This fluid is being recommended as potential industrial reference material for high viscosity-high pressure measurements. Here we report new experimental viscosity ...

A new and fast HPLC-method for the simultaneous determination of tri-(2-ethylhexyl) trimellitate (TOTM or TEHTM), its diesters 2,4-di-(2-ethylhexyl) trimellitate (2,4-DEHTM), 1,4-di-(2-ethylhexyl) trimellitate (1,4-DEHTM), 1,2-di-(2-ethylhexyl) trimellitate (1,2-DEHTM) and monoesters 1-mono-(2-e...

Intravenous injection of crushed Ritalin (methylphenidate 10 mg) tablets has emerged as a current medical concern in New Zealand. We report the clinical features of four cases of methylphenidate toxicity arising from intravenous (IV) injection of crushed Ritalin tablets, and highlight concerns r...

They found increased formation of spiny neurons, linked with addiction in the nuclear accumbens, a region of the brain stimulated by all addictive drugs