Urea supplier | CasNO.57-13-6

Name
Urea
EINECS 200-315-5
CAS No. 57-13-6
Article Data996
CAS DataBase
Density 1.32 g/cm³
Solubility in water: 51.8 g/100 ml (20 °C), 54.5 g/100ml (25 °C), 71.7 g/100 ml (60 °C), 95.0 g/100 ml (120 °C)
Melting Point 131-135 °C
Formula CH₄N₂O
Boiling Point 196.611 °C at 760 mmHg
Molecular Weight 60.0556
Flash Point 72.708 °C
Transport Information
Appearance white solid
Safety 26-36-24/25
Risk Codes 36/37/38-40
Molecular Structure
Hazard Symbols Xi,Xn
Synonyms Carbamide;Carbonyl diamide;Carbonyldiamine;Diaminomethanal;Diaminomethanone;Prespersion, 75 urea;Urea-13C;Ureacin-20;Urepearl;
PSA 69.11000
LogP 0.42440

Synthetic route

: 22981-32-4
ammonium cyanate

: 57-13-6
urea

Conditions

Conditions	Yield
In ethanol at 32°C;	100%
In ethanol at 32°C;	100%
In water Kinetics; izomerization; equil. react.;

: 868-84-8
S,S-dimethyl dithiocarbonate

: 57-13-6
urea

Conditions

Conditions	Yield
With ammonia; water at 60℃; for 2h;	100%

: 201230-82-2
carbon monoxide

: 7664-41-7
ammonia

: 7704-34-9
sulfur

A: 7783-06-4
hydrogen sulfide

B: 57-13-6
urea

Conditions

Conditions	Yield
In methanol; water molar ratio of CO:S = 1.36; 35 min; at 110°C; 60% excess of NH3; 75% CH3OH;	A n/a B 96.2%
In methanol; water molar ratio of NH3:S:CO = 1.4 : 1 : 1.36; 35 min; at 110°C; 54% CH3OH;	A n/a B 96.2%
In methanol; water molar ratio of NH3:S:CO = 1.4 : 1 : 1.36; 35 min; at 110°C; 54% CH3OH;	A n/a B 96.3%

...Expand

: 17356-08-0
thiourea

: 57-13-6
urea

Conditions

Conditions	Yield
With bismuth(III) nitrate In acetonitrile for 0.25h; Heating;	96%
With Oxone for 0.0833333h;	96%
With 3-carboxypyridinium chlorochromate In acetonitrile for 0.0333333h; Product distribution; Further Variations:; Reagents; Temperatures; without microwave irradiation; solvent-free; microwave irradiation;	95%

: 381-73-7
Difluoroacetic acid

: 20017-67-8
3,3-diphenylpropan-1-ol

A: difluoroacetic acid, O-(3,3-diphenyl-propyl) ester

B: 57-13-6
urea

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In diethyl ether at 0 - 20℃;	A 96% B n/a

...Expand

: 556-89-8
nitrourea

: 7664-41-7
ammonia

A: 57-13-6
urea

B: 7782-94-7
nitramine

Conditions

Conditions	Yield
In ammonia at -33°C;	A 91% B n/a

...Expand

: 67969-82-8
tetrafluoroboric acid diethyl ether

: F6P(1-)*C25H43Fe2N2OS2(1+)

: 75-05-8
acetonitrile

A: F6P(1-)*C26H44Fe2N4S2(2+)*BF4(1-)

B: 57-13-6
urea

Conditions

Conditions	Yield
In acetone at 20℃; for 2h; Inert atmosphere; Schlenk technique;	A 90% B 90%

...Expand

: 124-41-4
sodium methylate

: 80981-23-3
4-ureidocarbonylpyrazole

A: 51105-90-9
methyl pyrazole-4-carboxylate

B: 57-13-6
urea

Conditions

Conditions	Yield
In methanol for 2h; Heating;	A 89% B n/a

...Expand

: 463-58-1
carbon oxide sulfide

: 7664-41-7
ammonia

A: 7783-06-4
hydrogen sulfide

B: 57-13-6
urea

Conditions

Conditions	Yield
1.5-fold molar excess of NH3; at 105°C;	A n/a B 88%
In ethanol at a temp. near the m.p. of urea; using abs. ethanol;	A n/a B 76%
In ammonia at a temp. near the m.p. of urea;	A n/a B 64%

...Expand

: 13463-40-6
iron pentacarbonyl

: 7664-41-7
ammonia

A: 2NH4(1+)*{Fe(CO)4}(2-)=(NH4)2{Fe(CO)4}

B: 57-13-6
urea

Conditions

Conditions	Yield
With ammonium chloride In ammonia at exclusion of light, air and moisture; 20°C; 5 d;	A n/a B 85%
In ammonia at exclusion of light, air and moisture; 20°C; 5 d;	A n/a B 77%
In ammonia at exclusion of light, air and moisture; 20°C; 1 d;	A n/a B 31%
In ammonia at exclusion of light, air and moisture; 20°C; 14 d;	A n/a B >99

...Expand

: 420-04-2
CYANAMID

: 57-13-6
urea

Conditions

Conditions	Yield
With [OsCl2(η6-p-cymene)(PMe2OH)]; water at 40℃; for 0.25h; Reagent/catalyst; Inert atmosphere; Sealed tube;	80%
With sulfuric acid

: 16687-42-6
ammonium oxythiocarbamate

A: 22981-32-4
ammonium cyanate

B: 7704-34-9
sulfur

C: 57-13-6
urea

Conditions

Conditions	Yield
In ethanol storing in air; elimination of the ppt.; crystn. S by HgO at low temp.;	A n/a B n/a C 80%
In ethanol storing in air; elimination of the ppt.; crystn. S by HgO at low temp.;	A n/a B n/a C 80%
In ethanol storing in air; elimination of the ppt.; crystn. S by HgO at low temp.;	A n/a B n/a C 80%

...Expand

: 124-38-9
carbon dioxide

: 7664-41-7
ammonia

: 57-13-6
urea

Conditions

Conditions	Yield
at molar ratio of NH3:CO2 = 8;	77%
High Pressure; at 175 until 180°C; at a pressure of 175 at; molar ratio of NH3:CO2 = 6; liquid phase;	76%
at molar ratio of NH3:CO2 = 6;	72%

: 71-23-8
propan-1-ol

: 201230-82-2
carbon monoxide

: 109-55-7
1-amino-3-(dimethylamino)propane

A: 24579-73-5
propamocarb

B: 57-13-6
urea

Conditions

Conditions	Yield
With oxygen; N,N-dimethyl-formamide; sodium iodide; palladium dichloride at 125℃; under 30003 Torr; for 2h; Pressure; Reagent/catalyst; Autoclave; Inert atmosphere;	A 75.6% B 5.7%

...Expand

: nitro-carboxamide

A 5-Amino-4-chloro-2-[8'-benzyl-8'-azabicyclo-[3.2.1]octane-3'β-carboxamido]-anisole: 5-Amino-4-chloro-2-[8'-benzyl-8'-azabicyclo-[3.2.1]octane-3'β-carboxamido]-anisole

B: 57-13-6
urea

Conditions

Conditions	Yield
aluminum nickel In ethanol	A 73% B n/a

: 69-93-2
uric Acid

A: 61066-33-9, 61066-34-0, 61066-35-1, 61127-23-9
pyrimidine-2,4,5,6(1H,3H)-tetraone

B: 57-13-6
urea

Conditions

Conditions	Yield
With rose bengal; sodium hydroxide In glycerol for 36h; Irradiation;	A 72.18% B n/a

: 154866-92-9
ethyl 4-(4-chlorophenyl)-1,2,3,4-tetrahydro-6-methyl-2-thioxopyrimidine-5-carboxylate

A: 52372-80-2
(4-chlorobenzylidene)hydrazine

B: 17356-08-0
thiourea

C: 57-13-6
urea

D: 132712-71-1, 4344-87-0, 145091-87-8
5-hydroxy-3-methylpyrazole

Conditions

Conditions	Yield
With hydrazine hydrate In neat (no solvent) for 6h; Reflux;	A 70% B n/a C n/a D 55%

...Expand

: 185023-34-1
5-carboethoxy-6-methyl-4-(4-methylphenyl)-1H-pyrimidin-2-thione

A: 52693-87-5
4-methylbenzaldehyde hydrazone

B: 17356-08-0
thiourea

C: 57-13-6
urea

D: 132712-71-1, 4344-87-0, 145091-87-8
5-hydroxy-3-methylpyrazole

Conditions

Conditions	Yield
With hydrazine hydrate In neat (no solvent) for 6h; Reflux;	A 69% B n/a C n/a D 55%

...Expand

: 7664-41-7
ammonia

polycarbonate: polycarbonate

A: 80-05-7
BPA

B: 57-13-6
urea

Conditions

Conditions	Yield
In ethanol; water at 80℃; for 12h; Green chemistry;	A n/a B 68%

...Expand

: 123043-88-9, 33458-26-3
5-ethoxycarbonyl-4-phenyl-6-methyl-3,4-dihydropyrimidine-2(1H)-thione

A: 5281-18-5
benzaldehyde, hydrazone

B: 17356-08-0
thiourea

C: 57-13-6
urea

D: 132712-71-1, 4344-87-0, 145091-87-8
5-hydroxy-3-methylpyrazole

Conditions

Conditions	Yield
With hydrazine hydrate In neat (no solvent) for 6h; Reflux;	A 67% B n/a C n/a D 55%

...Expand

: 71-23-8
propan-1-ol

: 201230-82-2
carbon monoxide

: 109-73-9
N-butylamine

A: 57-13-6
urea

B: 100823-18-5
n-propyl N-n-butyl carbamate

Conditions

Conditions	Yield
With oxygen; triethylamine; sodium iodide; palladium dichloride at 165℃; Reagent/catalyst; Autoclave; Inert atmosphere;	A 66% B 8%

...Expand

: 113697-57-7
5-(ethoxycarbonyl)-4-(4-methoxyphenyl)-6-methyl-3,4-dihydropyrimidin-2(1H)-thione

A: 5953-85-5
p-anisaldehyde hydrazone

B: 17356-08-0
thiourea

C: 57-13-6
urea

D: 132712-71-1, 4344-87-0, 145091-87-8
5-hydroxy-3-methylpyrazole

Conditions

Conditions	Yield
With hydrazine hydrate In neat (no solvent) for 6h; Reflux;	A 66% B n/a C n/a D 55%

...Expand

: 5948-71-0
4-(4-chlorophenyl)-5-(ethoxycarbonyl)-6-methyl-3,4-dihydropyrimidin-2(1H)-one

A: 52372-80-2
(4-chlorobenzylidene)hydrazine

B: 17356-08-0
thiourea

C: 57-13-6
urea

D: 132712-71-1, 4344-87-0, 145091-87-8
5-hydroxy-3-methylpyrazole

Conditions

Conditions	Yield
With hydrazine hydrate In neat (no solvent) for 6h; Reflux;	A 62% B n/a C n/a D 55%

...Expand

: 123237-03-6, 5395-36-8
ethyl 6-methyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one-5-carboxylate

A: 5281-18-5
benzaldehyde, hydrazone

B: 17356-08-0
thiourea

C: 57-13-6
urea

D: 132712-71-1, 4344-87-0, 145091-87-8
5-hydroxy-3-methylpyrazole

Conditions

Conditions	Yield
With hydrazine hydrate In neat (no solvent) for 6h; Reflux;	A 62% B n/a C n/a D 55%

...Expand

: 124-38-9
carbon dioxide

: 7664-41-7
ammonia

: 7732-18-5
water

: 57-13-6
urea

Conditions

Conditions	Yield
at 190℃; under 112511 Torr;	61%

...Expand

: 161374-07-8
ethyl 4-(4-methoxyphenyl)-6-methyl-1,2,3,4-tetrahydropyrimidin-2-one-5-carboxylate

A: 5953-85-5
p-anisaldehyde hydrazone

B: 17356-08-0
thiourea

C: 57-13-6
urea

D: 132712-71-1, 4344-87-0, 145091-87-8
5-hydroxy-3-methylpyrazole

Conditions

Conditions	Yield
With hydrazine hydrate In neat (no solvent) for 6h; Reflux;	A 60% B n/a C n/a D 55%

...Expand

: 299949-24-9
ethyl 6-methyl-2-oxo-4-p-tolyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate

A: 52693-87-5
4-methylbenzaldehyde hydrazone

B: 17356-08-0
thiourea

C: 57-13-6
urea

D: 132712-71-1, 4344-87-0, 145091-87-8
5-hydroxy-3-methylpyrazole

Conditions

Conditions	Yield
With hydrazine hydrate In neat (no solvent) for 6h; Reflux;	A 58% B n/a C n/a D 55%

...Expand

: ammonium carbamate

A: 7732-18-5
water

B: 57-13-6
urea

Conditions

Conditions	Yield
Kinetics; at 200°C;	A n/a B 55%
Kinetics; at 200°C;	A n/a B 55%
Kinetics; at 140°C;	A n/a B 43%

: 69-93-2
uric Acid

A: 102636-37-3
5,6-dihydroxypyrimidine-2,4(1H,3H)-dione

B: 57-13-6
urea

Conditions

Conditions	Yield
With rose bengal In acetic acid; glycerol for 38h; Irradiation;	A 45.11% B n/a

: 108-31-6
maleic anhydride

: 57-13-6
urea

: 105-61-3
maleuric acid

Conditions

Conditions	Yield
With acetic acid at 50℃; for 12h;	100%
With acetic acid
at 80℃;
at 100 - 105℃;
With acetic acid

: 141-97-9
ethyl acetoacetate

: 555-16-8
4-nitrobenzaldehdye

: 57-13-6
urea

: 123371-45-9
ethyl 6-methyl-4-(4-nitrophenyl)-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate

Conditions

Conditions	Yield
With 1-methylimidazole based ionic liquid terminated dendritic moiety prepared from 2,4,6-trichloro-1,3,5-triazine and 1,3-diaminopropane immobilized on 3-aminopropyltriethoxysilane functionalized bentonite In ethanol; water at 50℃; for 3h; Biginelli Pyrimidone Synthesis; Green chemistry;	100%
With guanidine In neat (no solvent) at 80℃; for 2h; Biginelli Pyrimidone Synthesis;	99%
With 1,4-diazaniumbicyclo[2.2.2]octane diacetate In neat (no solvent) at 80℃; for 0.0833333h; Biginelli Pyrimidone Synthesis; Green chemistry;	99%

...Expand

: 141-97-9
ethyl acetoacetate

: 100-52-7
benzaldehyde

: 57-13-6
urea

: 123237-03-6, 5395-36-8
ethyl 6-methyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one-5-carboxylate

Conditions

Conditions	Yield
With copper(II) bis(trifluoromethanesulfonate) In ethanol at 100℃; for 1h; Biginelli reaction; Microwave irradiation; Inert atmosphere;	100%
With Cl7Fe2(1-)C6H9N2O2(1+); C8H15N2(1+)C4H12B(1-) at 80℃; for 2h; Reagent/catalyst; Biginelli Pyrimidone Synthesis;	99%
With guanidine In neat (no solvent) at 80℃; for 2h; Biginelli Pyrimidone Synthesis;	99%

...Expand

: 431-03-8
dimethylglyoxal

: 57-13-6
urea

: 28115-25-5
tetrahydro-3a,6a-dimethylimidazo<4,5-d>imidazole-2,5-(1H,3H)-dione

Conditions

Conditions	Yield
With H3PW12O40 In methanol at 20℃; for 5.5h;	100%
With 1-hydroxyethylene-(1,1-diphosphonic acid) In water at 80℃; for 1h; Green chemistry;	95%
With hydrogenchloride In water at 20℃; for 12h;	76%

: 95-84-1
3-amino-4-hydroxytoluene

: 57-13-6
urea

: 22876-15-9
5-methylbenzo[d]oxazol-2(3H)-one

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 145 - 150℃; for 3.5h;	100%
at 144.85 - 149.85℃; for 4h;	59.69%
In N,N-dimethyl-formamide for 5h; Carbonylation; Heating;	55%

: 57-13-6
urea

: 774-40-3, 4358-88-7
hydroxy-phenyl-acetic acid ethyl ester

: 5841-63-4
5-phenyloxazolidine-2,4-dione

Conditions

Conditions	Yield
With sodium ethanolate; sodium hydride In ethanol at 0℃; for 2.5h; Reflux;	100%
With sodium ethanolate In ethanol at 0℃; for 4h; Reflux;	17.04%
With sodium methylate Hydrolysieren des Reaktionsprodukts;

: 57-13-6
urea

: 89-77-0
2-Amino-4-chlorobenzoic acid

: 13165-35-0
7-chloroquinazoline-2,4-dione

Conditions

Conditions	Yield
at 200℃; for 1h;	100%
at 200℃; for 2h;	85%
With sodium hydroxide In water for 120h; Heating;	33%

: 57-13-6
urea

: 29878-39-5
urea, monosodium salt

Conditions

Conditions	Yield
With sodium hydride; toluene at 25 - 90℃; for 1.5h; Reagent/catalyst;	100%
With sodium methylate In methanol; 5,5-dimethyl-1,3-cyclohexadiene at 120℃;	93%
With sodium methylate In methanol; 5,5-dimethyl-1,3-cyclohexadiene at 120℃;	93%
With ammonia; sodium

: 141-97-9
ethyl acetoacetate

: 123-11-5
4-methoxy-benzaldehyde

: 57-13-6
urea

: 161374-07-8
ethyl 4-(4-methoxyphenyl)-6-methyl-1,2,3,4-tetrahydropyrimidin-2-one-5-carboxylate

Conditions

Conditions	Yield
With piperidine In ethanol for 4h; Heating;	100%
With copper(II) bis(trifluoromethanesulfonate) In ethanol at 100℃; for 1h; Biginelli reaction; Microwave irradiation; Inert atmosphere;	100%
With CuCl2*2H2O for 0.025h; Biginelli condensation; microwave irradiation;	99%

...Expand

: 3327-24-0
1-(2-hydroxyphenyl)-3-(4-methoxyphenyl)-2-propen-1-one

: 57-13-6
urea

: 2-oxo-4-(o-hydroxyphenyl)-6-(p-methoxyphenyl)-1,3,6-trihydro-pyrimidine

Conditions

Conditions	Yield
With sulfuric acid In ethanol for 8h; Heating;	100%

: 141-97-9
ethyl acetoacetate

: 104-88-1
4-chlorobenzaldehyde

: 57-13-6
urea

: 5948-71-0
4-(4-chlorophenyl)-5-(ethoxycarbonyl)-6-methyl-3,4-dihydropyrimidin-2(1H)-one

Conditions

Conditions	Yield
With copper(II) bis(trifluoromethanesulfonate) In ethanol at 100℃; for 1h; Biginelli reaction; Microwave irradiation; Inert atmosphere;	100%
With [1-(3-sulfonic acid)]propyl-3-methylimidazolium hydrogen sulfate In ethanol at 80℃; for 3h; Time; Biginelli Pyrimidone Synthesis;	99%
Stage #1: ethyl acetoacetate; 4-chlorobenzaldehyde With secondary amine linked triazine and pyrene containing microporous organic polymer at 40 - 80℃; for 0.5h; Stage #2: urea for 2h; Biginelli Pyrimidone Synthesis; Reflux;	99%

...Expand

: 123-11-5
4-methoxy-benzaldehyde

: 105-45-3
acetoacetic acid methyl ester

: 57-13-6
urea

: 205999-87-7
5-methoxycarbonyl-4-(4-methoxyphenyl)-6-methyl-3,4-dihydropyrimidin-2(1H)-one

Conditions

Conditions	Yield
With sulfuric acid; copper(l) chloride In methanol Biginelli Pyrimidone Synthesis; Reflux; Inert atmosphere;	100%
With ytterbium(III) triflate at 100℃; for 0.333333h; Biginelli reaction;	99%
With calcium chloride In ethanol for 2h; Biginelli reaction; Heating;	98%

...Expand

: 123-11-5
4-methoxy-benzaldehyde

: 57-13-6
urea

: 4949-44-4
ethyl propanoylacetate

: ethyl 6-ethyl-4-(4-methoxyphenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Conditions

Conditions	Yield
With copper(II) bis(trifluoromethanesulfonate) In ethanol at 100℃; for 1h; Biginelli reaction; Microwave irradiation; Inert atmosphere;	100%
With Aliquat 336; sodium hydroxide In water at 100℃; for 0.75h; Reagent/catalyst; Solvent; Temperature; Time;	91%
With zinc(II) oxide In water for 0.416667h; Biginelli Pyrimidone Synthesis;	86%

...Expand

: 141-97-9
ethyl acetoacetate

: 57-13-6
urea

: 6630-33-7
ortho-bromobenzaldehyde

: ethyl 4-(2-bromophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Conditions

Conditions	Yield
With copper(II) bis(trifluoromethanesulfonate) In ethanol at 100℃; for 1h; Biginelli reaction; Microwave irradiation; Inert atmosphere;	100%
With ytterbium(III) triflate at 100℃; for 0.666667h; Biginelli reaction;	97%
With 2,2,2-trifluoroethanol at 80℃; Biginelli pyrimidine synthesis;	94%

...Expand

: 104-87-0
4-methyl-benzaldehyde

: 141-97-9
ethyl acetoacetate

: 57-13-6
urea

: 299949-24-9
ethyl 6-methyl-2-oxo-4-p-tolyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Conditions

Conditions	Yield
With copper(II) bis(trifluoromethanesulfonate) In ethanol at 100℃; for 1h; Biginelli reaction; Microwave irradiation; Inert atmosphere;	100%
polystyrene-methylimidazolium(1+)*PF6(1-) In acetic acid at 100℃; for 2h;	99%
With indium(III) bromide In ethanol for 7h; Biginelli condensation; Heating;	98%

...Expand

: 89-95-2
2-methyl-benzyl alcohol

: 141-97-9
ethyl acetoacetate

: 57-13-6
urea

: 5948-68-5
ethyl 4-(2-hydroxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Conditions

Conditions	Yield
With piperidine In ethanol for 4h; Heating;	100%
With 3-ethoxycarbonylmethyl-1-methylimidazolium hydrogen sulfate at 80℃; for 0.25h; Biginelli reaction;	92%
With In(OSO2CF3)3 for 0.183333h; Biginelli reaction; microwave irradiation;	91%

...Expand

: 141-97-9
ethyl acetoacetate

: 66-77-3
1-naphthaldehyde

: 57-13-6
urea

: 219814-93-4, 1032574-17-6
6-methyl-4-naphthalen-1-yl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester

Conditions

Conditions	Yield
With copper(II) bis(trifluoromethanesulfonate) In ethanol at 100℃; for 1h; Biginelli reaction; Microwave irradiation; Inert atmosphere;	100%
With copper doped mesoporous silica MCM-41 supported dual acidic ionic liquid-HSO4 In ethanol at 80℃; for 1h; Biginelli Pyrimidone Synthesis;	97%
Stage #1: 1-naphthaldehyde; urea With hydrogenchloride In tetrahydrofuran; water at 67℃; for 1h; Biginelli Pyrimidone Synthesis; Green chemistry; Stage #2: ethyl acetoacetate With N,N′-(cyclohexane-1,2-diyl)bis(3,6-dichloropicolinamide) In tetrahydrofuran; water at 67℃; for 5h; Biginelli Pyrimidone Synthesis; Green chemistry;	95%

...Expand

: 485-47-2
indan-1,2,3-trione hydrate

: 57-13-6
urea

: 22431-00-1
3a,8a-dihydroxy-1,3,3a,8a-tetrahydroindeno[1,2-d]imidazole-2,8-dione

Conditions

Conditions	Yield
at 80℃; for 1h;	100%
In water at 20℃; for 0.833333h; Green chemistry;	98%
In water at 50 - 60℃;	93%

: 57-13-6
urea

: 556-89-8
nitrourea

Conditions

Conditions	Yield
With nitric acid for 2h;	100%
With nitric acid at 20℃; for 2h; Neat (no solvent);	100%
With nitric acid at 20℃; for 2h;	100%

: 38335-24-9
3-(4-nitrophenyl)-2-oxopropanoic acid

: 100-52-7
benzaldehyde

: 57-13-6
urea

: 5-(4-nitro-phenyl)-2-oxo-6-phenyl-1,2,3,6-tetrahydro-pyrimidine-4-carboxylic acid

Conditions

Conditions	Yield
With methanesulfonic acid In ethanol for 24h; Biginelli reaction; Heating;	100%

...Expand

: 57-13-6
urea

: 791-28-6
Triphenylphosphine oxide

: 2,2,2-triphenyl-1H-1,3,2,λ5-diazaphosphotidin-4-one

Conditions

Conditions	Yield
at 95 - 100℃; for 4h;	100%

: 212322-17-3
methyl 3-amino-4-formylbenzoate

: 57-13-6
urea

: 953039-78-6
methyl 2-hydroxy-quinazoline-7-carboxylate

Conditions

Conditions	Yield
at 145℃; for 16h;	100%

: 42465-53-2
1-(2-amino-4-methoxyphenyl)ethanone

: 57-13-6
urea

: 37528-39-5
7-methoxy-4-methyl-quinazolin-2-ol

Conditions

Conditions	Yield
With acetic acid at 100℃; for 16h;	100%

: 42465-54-3
1-(2-amino-3-methoxyphenyl)ethanone

: 57-13-6
urea

: 953039-91-3
8-methoxy-4-methyl-quinazolin-2-ol

Conditions

Conditions	Yield
With acetic acid at 100℃; for 16h;	100%

: 141-97-9
ethyl acetoacetate

: 57-13-6
urea

: 3446-89-7
4-(Methylthio)benzaldehyde

: 423737-44-4
ethyl 6-methyl-4-[4-(methylsulfanyl)phenyl]-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate

Conditions

Conditions	Yield
With copper(II) bis(trifluoromethanesulfonate) In ethanol at 100℃; for 1h; Biginelli reaction; Microwave irradiation; Inert atmosphere;	100%
Wells-Dawson heteropolyacid catalyst at 80℃; for 1.5h; Biginelli reaction;	92%
With 25,26,27,28-terahydroxycalix[4]arene-5,11,7,23-tetrasulfonic acid In ethanol for 8h; Biginelli reaction; Reflux;	92%

...Expand

: C20H8N2O4

: 57-13-6
urea

: 7646-85-7
zinc(II) chloride

: C80H32N8O16Zn

Conditions

Conditions	Yield
With ammonium molibdate; 1,8-diazabicyclo[5.4.0]undec-7-ene at 240℃; for 3h;	100%

...Expand

: 877681-24-8
(2R)-2-hydroxy-2-(3-methylphenyl)propanoic acid methyl ester

: 57-13-6
urea

: 875542-02-2
(5R)-5-methyl-5-(3-methylphenyl)oxazolidine-2,4-dione

Conditions

Conditions	Yield
With sodium ethanolate In ethanol at 95℃;	100%
With sodium ethanolate In ethanol Heating / reflux;
With sodium ethanolate In ethanol at 95℃; Heating / reflux;

: 443107-13-9
5-Amino-1-(2-phenylethyl)-1H-pyrazole-4-carboxylic acid

: 57-13-6
urea

: 443107-17-3
C13H12N4O2

Conditions

Conditions	Yield
at 180℃;	100%

: 67-48-1
choline chloride

: 57-13-6
urea

: urea/choline chloride eutectic salt

Conditions

Conditions	Yield
at 70 - 80℃; for 0.333333h;	100%
at 120℃; for 0.333333h; Neat (no solvent);
at 74℃;

Urea Specification

Urea is a weak base and a organic compound with the formula CH₄N₂O. Urea is also called as carbamide which is white crystalline powder. It is highly soluble in water and non-toxic. Urea reacts with azo and diazo compounds to generate toxic gases, and reacts with strong reducing agents to form flammable gases. Urea should be sealed and stored in cool and dry place.

Physical properties about Urea are: (1)ACD/LogP: -1.66; (2)ACD/LogD (pH 5.5): 1.66; (3)ACD/LogD (pH 7.4): -1.66; (4)ACD/BCF (pH 5.5): 1.00; (5)ACD/BCF (pH 7.4): 1.00; (6)ACD/KOC (pH 5.5): 2.98; (7)ACD/KOC (pH 7.4): 2.98; (8)#H bond acceptors: 3; (9)#H bond donors: 4; (10)Index of Refraction: 1.469; (11)Molar Refractivity: 13.782 cm³; (12)Molar Volume: 49.517 cm3; (13)Polarizability: 5.464 10-24cm³; (14)Surface Tension: 55.3680000305176; (15)dyne/cm Density: 1.213 g/cm³; (16)Flash Point: 72.708 °C; (17)Enthalpy of Vaporization: 43.281 kJ/mol; (18)Boiling Point: 196.611 °C at 760 mmHg; (19)Vapour Pressure: 0.395000010728836 mmHg at 25°C

Preparation of Urea: The synthesis of Urea from an inorganic precursor was an important milestone in the development of organic chemistry, as it showed for the first time that a molecule found in living organisms could be synthesized in the lab without biological starting materials. In addition, Urea can be prepared by treating silver isocyanate with ammonium chloride.

AgNCO + NH₄Cl → (NH₂)₂CO + AgCl

The Urea can also be prepared by ammonia and carbon dioxide. The mixture reacts to generate ammonium carbamate. Finally, you can gain Urea through dehydration.

NH₃ + CO₂ → H₂NCONH₄ → H₂NCONH₂

Meanwhile, the Urea can also be prepared by calcium cyanamide and sulfuric acid. The mixture reacts and generates cyanamide. After that, it reacts with H₂O. Via decoloration and recrystallization, you can gain Urea.

CaNCN + H₂SO₄ → NH₂CN + CaSO₄NH₂CN + H₂O → NH₂CONH₂

Uses of Urea : Urea is used as a nitrogen-release fertilizer in agriculture. In chemical industry it is a raw material for the manufacture of many important chemicals, such as: various plastics, especially the urea-formaldehyde resins; various adhesives, such as urea-formaldehyde or the urea-melamine-formaldehyde used in marine plywood ; potassium cyanate, another industrial feedstock; Urea nitrate, an explosive. And also Urea is used in topical dermatological products to promote rehydration of the skin. If covered by an occlusive dressing, 40% Urea preparations may also be used for nonsurgical debridement of nails. This Urea is also used as an earwax removal aid.

When you are using Urea, please be cautious about it: Urea is irritating to eyes, respiratory system and skin. And limited evidence of a carcinogenic effect. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. Moreover, you should wear suitable protective clothing to avoid contact Urea with skin and eyes.

People can use the following data to convert to the molecule structure of Urea:
(1)SMILES: C(=O)(N)N
(2)InChI: InChI=1/CH4N2O/c2-1(3)4/h(H4,2,3,4)
(3)InChIKey: XSQUKJJJFZCRTK-UHFFFAOYAF

Toxicity of Urea:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LDLo	intravenous	3gm/kg (3000mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1353, 1935.
dog	LDLo	subcutaneous	3gm/kg (3000mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1353, 1935.
domestic animals - goat/sheep	LDLo	oral	511mg/kg (511mg/kg)	BEHAVIORAL: TETANY GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS LUNGS, THORAX, OR RESPIRATION: DYSPNEA	American Journal of Physiology. Vol. 153, Pg. 41, 1948.
frog	LDLo	subcutaneous	600mg/kg (600mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1353, 1935.
mouse	LD50	intravenous	4600mg/kg (4600mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: ANTIPSYCHOTIC	Oyo Yakuri. Pharmacometrics. Vol. 13, Pg. 749, 1977.
mouse	LD50	oral	11gm/kg (11000mg/kg)		Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 31(12), Pg. 53, 1987.
mouse	LD50	subcutaneous	9200mg/kg (9200mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: ANTIPSYCHOTIC	Oyo Yakuri. Pharmacometrics. Vol. 13, Pg. 749, 1977.
mouse	LDLo	intraperitoneal	6608mg/kg (6608mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: COMA	Journal of Pharmacology and Experimental Therapeutics. Vol. 57, Pg. 19, 1936.
pigeon	LDLo	subcutaneous	14800mg/kg (14800mg/kg)		"Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation," Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1931Vol. -, Pg. -, 1931.
rabbit	LDLo	intravenous	4800mg/kg (4800mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1353, 1935.
rabbit	LDLo	oral	10gm/kg (10000mg/kg)	BRAIN AND COVERINGS: OTHER DEGENERATIVE CHANGES LUNGS, THORAX, OR RESPIRATION: STRUCTURAL OR FUNCTIONAL CHANGE IN TRACHEA OR BRONCHI BLOOD: HEMORRHAGE	Japanese Journal of Veterinary Science. Vol. 15, Pg. 125, 1953.
rabbit	LDLo	subcutaneous	3gm/kg (3000mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1353, 1935.
rat	LD50	intraperitoneal	> 5gm/kg (5000mg/kg)		Naunyn-Schmiedebergs Archiv fuer Pharmakologie und Experimentelle Pathologie. Vol. 257, Pg. 296, 1967.
rat	LD50	intratracheal	567mg/kg (567mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN	Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 30(3), Pg. 43, 1986.
rat	LD50	intravenous	5300mg/kg (5300mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: ANTIPSYCHOTIC BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)	Oyo Yakuri. Pharmacometrics. Vol. 13, Pg. 749, 1977.
rat	LD50	oral	8471mg/kg (8471mg/kg)		Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 51(6), Pg. 8, 1986.
rat	LD50	subcutaneous	8200mg/kg (8200mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: ANTIPSYCHOTIC	Oyo Yakuri. Pharmacometrics. Vol. 13, Pg. 749, 1977.

Product Name

Urea

Synthetic route

Urea Specification

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