As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
Cas:191171-55-8
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inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:191171-55-8
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:191171-55-8
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inquiry2-Aminophenylboronic acid pinacol ester Basic information Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable bus
Cas:191171-55-8
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inquiryOur advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva
Cas:191171-55-8
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:191171-55-8
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inquiry1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powd
Cas:191171-55-8
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:191171-55-8
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inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese
Cas:191171-55-8
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FOB Price: $76.0 / 85.0
Type:Trading Company
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquiryBest quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
Cas:191171-55-8
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inquiryTriumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Service 1.Own made fine chemical products 2.Out sourcing and qua
Cas:191171-55-8
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Cas:191171-55-8
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inquiryPacking: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once Transportation:Express/Sea/Air Port:Ningbo/Shanghai/Qingd
Cas:191171-55-8
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inquirySuperior quality Appearance:cream crystalline powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:1kg/bag, 1kg/drum or 25kg/drum or as per your request. Application:Used as Pharmaceutical Intermediates Transpor
Cas:191171-55-8
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Type:Trading Company
inquiry2-Aminophenylboronic acid pinacol ester Basic information Product Name: 2-Aminophenylboronic acid pinacol ester Synonyms: 2-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)ANILINE;2-AMINOPHENYLBORONIC ACID, PINACOL CYCLIC ESTER;2-AMINOPHENYLBORON
Cas:191171-55-8
Min.Order:1 Gram
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inquiryAppearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea
Cas:191171-55-8
Min.Order:0
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Type:Manufacturers
inquiryHigh quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use
Cas:191171-55-8
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inquiryStock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai
Cas:191171-55-8
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inquiry1.A strong technical force and advanced processing equipments. The quality of the products has been strictly inspected and all kinds of index have reached or exceeded domestic and international standards.2. Now we have established long-term stable re
Cas:191171-55-8
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inquiryhigh purity,in stock Package:25kg/drum,or as per customers'demand Application:API,Pharmaceutical intermediates Transportation:air,sea,courier
Cas:191171-55-8
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Type:Lab/Research institutions
inquirymanufacture Application:The refence standard products, for lab use, also we could produce bigger quantity on yr requirement.
Cas:191171-55-8
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Type:Lab/Research institutions
inquiryhigh qualityAppearance:White or off white powder Storage:Sealed, dry, microtherm , avoid light and smell Package:According to the demand of customer Application:Pharmaceutical intermediates Transportation:by air or by sea
Cas:191171-55-8
Min.Order:0
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Type:Manufacturers
inquiryOur clients, like BASF,CHEMO,Brenntag,ASR,Evonik,Merck and etc.Appearance:COA Storage:in stock Application:MSDS/TDS
Cas:191171-55-8
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inquiryhigh purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:Beijing or Guangzhou
Cas:191171-55-8
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inquiryTAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp
Cas:191171-55-8
Min.Order:0
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Type:Manufacturers
inquiryOur Company main product 一:suzuki reaction customization 二:Boronic acid derivative ①:phenylboronic acid derivative ②:Phenylboronic acid pinacol ester derivative ③:Potassium phenyltrifluoroborate derivative ④:Phenylboronic acid MIDA ester derivative
Cas:191171-55-8
Min.Order:0 Metric Ton
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Type:Lab/Research institutions
inquiryAnsciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali
Cas:191171-55-8
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Type:Lab/Research institutions
inquiry2-bromoaniline
bis(pinacol)diborane
2-anilineboronic acid pinacol ester
Conditions | Yield |
---|---|
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate In N,N-dimethyl-formamide for 12h; Reflux; | 98% |
With [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II); potassium acetate In dimethyl sulfoxide at 85℃; for 12h; Inert atmosphere; | 87% |
With tris(trimethylphosphine)nickel(II) chloride; (2,2,2-trifluoroethoxy)trimethylsilane; cesium fluoride In toluene at 100℃; for 1h; Inert atmosphere; | 84% |
2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nitrobenzene
2-anilineboronic acid pinacol ester
Conditions | Yield |
---|---|
With 5%-palladium/activated carbon; hydrogen In ethyl acetate at 80℃; for 4h; Temperature; Solvent; Inert atmosphere; | 95.8% |
2-iodophenylamine
4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane
2-anilineboronic acid pinacol ester
Conditions | Yield |
---|---|
With dichlorobis(chlorodi-tert-butylphosphine) palladium(II); triethylamine In toluene for 2h; Inert atmosphere; Reflux; | 95% |
With N(CH2CH3)3; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 In 1,4-dioxane (Ar); addn. of triethylamine, palladium compd. and borane deriv. to dioxane soln. of aniline deriv., heating at 100°C for 5 h; | 84% |
With triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride In further solvent(s) byproducts: C6H5NH2; (Ar); addn. of 2-IC6H4NH2 to suspn. of PdCl2(dppf) in 1-butyl-3-methylimidazolium tetrafluoroborate; stirring at 100°C; cooling to ambient temp., addn. of Et3N and then pinacolborane (2 equiv.); stirring at 100°C for 0.3 h; extn. with petroleum ether, removal of solvent; | 60% |
2-bromoaniline
4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane
2-anilineboronic acid pinacol ester
Conditions | Yield |
---|---|
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; triethylamine In 1,4-dioxane at 100℃; for 12h; | 87% |
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; triethylamine In 1,4-dioxane Inert atmosphere; | 84% |
With triethylamine; CyJohnPhos; palladium diacetate In 1,4-dioxane at 80℃; for 1h; | 81% |
2-Chloroaniline
bis(pinacol)diborane
2-anilineboronic acid pinacol ester
Conditions | Yield |
---|---|
With potassium phosphate tribasic heptahydrate; chloro(2-dicyclohexylphosphino-2’,4’,6’-triisopropyl-1,1‘-biphenyl)[2-(2’-amino-1,1‘-biphenyl’)]palladium(II); XPhos In ethanol at 20℃; for 1h; | 84% |
With tris(trimethylphosphine)nickel(II) chloride; (2,2,2-trifluoroethoxy)trimethylsilane; cesium fluoride In tetrahydrofuran at 100℃; for 12h; Inert atmosphere; | 80% |
With (2,2,2-trifluoroethoxy)trimethylsilane; cesium fluoride; dichlorobis(trimethylphosphine)nickel In tetrahydrofuran at 100℃; for 12h; Inert atmosphere; Sealed tube; | 80% |
With C52H67ClFeNPPd; potassium acetate In 1,4-dioxane at 110℃; for 3h; Suzuki-Miyaura coupling; Inert atmosphere; | 58% |
2,3-dimethyl-2,3-butane diol
2-aminophenylboronic acid
2-anilineboronic acid pinacol ester
Conditions | Yield |
---|---|
In tetrahydrofuran | 76% |
In tetrahydrofuran stirred under N2 overnight; evapn., chromy. (SiO2, EtOAc/toluene); | 76% |
2-iodophenylamine
bis(pinacol)diborane
2-anilineboronic acid pinacol ester
Conditions | Yield |
---|---|
With pyridine; C50H44CuN4OP2(1+)*F6P(1-); N-ethyl-N,N-diisopropylamine In water; acetonitrile at 20℃; for 12h; Inert atmosphere; Irradiation; | 71% |
With bis-(dimethylamino)methane In water; acetone; acetonitrile at -5℃; for 0.25h; UV-irradiation; Flow reactor; chemoselective reaction; | 60% |
With caesium carbonate In methanol for 24h; Reflux; Inert atmosphere; | 37% |
With pyridine; cesium fluoride In dimethyl sulfoxide at 105℃; for 2h; Inert atmosphere; Schlenk technique; | 17% |
2,3-dimethyl-2,3-butane diol
Trimethyl borate
2-anilineboronic acid pinacol ester
Conditions | Yield |
---|---|
Stage #1: Trimethyl borate; 2-bis(trimethylsilyl)aminophenyl lithium In tetrahydrofuran at -70 - -60℃; Inert atmosphere; Stage #2: 2,3-dimethyl-2,3-butane diol In tetrahydrofuran; methanol at 20℃; | 52% |
2-anilineboronic acid pinacol ester
Conditions | Yield |
---|---|
With hydrogenchloride In octane; water at 20℃; for 24h; Inert atmosphere; | 46% |
2-Chloroaniline
4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane
2-anilineboronic acid pinacol ester
Conditions | Yield |
---|---|
With triethylamine; CyJohnPhos; palladium diacetate In 1,4-dioxane at 100℃; for 2h; | 7% |
2-iodophenylamine
4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane
A
aniline
B
2-anilineboronic acid pinacol ester
Conditions | Yield |
---|---|
With triethylamine; 1-butyl-3-methylimidazolium Tetrafluoroborate; palladium diacetate at 100℃; for 6h; Product distribution; Further Variations:; Catalysts; reaction time; | A 33 % Chromat. B 61 % Chromat. |
2-bromoaniline
2-anilineboronic acid pinacol ester
2-nitrophenylboronic acid
2-anilineboronic acid pinacol ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: H2 / Pd/C / ethanol 2: 76 percent / tetrahydrofuran View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: HNO3; Ac2O; urea 2: H2 / Pd/C / ethanol 3: 76 percent / tetrahydrofuran View Scheme |
phenylboronic acid
2-anilineboronic acid pinacol ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: HNO3; Ac2O; urea 2: H2 / Pd/C / ethanol 3: 76 percent / tetrahydrofuran View Scheme |
aniline
4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane
A
2-anilineboronic acid pinacol ester
B
4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)aniline
C
3-aminophenylboronic acid pinacolate
Conditions | Yield |
---|---|
With (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 3,4,7,8-Tetramethyl-o-phenanthrolin; 1,2,3,4,5,6,7,8,9,10,11,12-dodecahydrotriphenylene In tetrahydrofuran at 80℃; for 16h; Inert atmosphere; Glovebox; regioselective reaction; |
2-nitrophenyl bromide
2-anilineboronic acid pinacol ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: iron; ammonium chloride / water; ethanol / 1 h / 90 °C 2: bis[1,2-bis(diphenylphosphino)ferrocene]-palladium(0); triethylamine / 1,4-dioxane / 12 h / 100 °C View Scheme |
2-(bis(trimethylsilyl)amino)phenyl bromide
2-anilineboronic acid pinacol ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: n-butyllithium / tetrahydrofuran; hexane / -70 °C / Inert atmosphere 2.1: tetrahydrofuran / -70 - -60 °C / Inert atmosphere 2.2: 20 °C View Scheme |
2-bromoaniline
2-anilineboronic acid pinacol ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: triethylamine / tetrahydrofuran / 0 - 60 °C / Inert atmosphere 1.2: -10 - 0 °C 2.1: n-butyllithium / tetrahydrofuran; hexane / -70 °C / Inert atmosphere 3.1: tetrahydrofuran / -70 - -60 °C / Inert atmosphere 3.2: 20 °C View Scheme |
aniline
bis(pinacol)diborane
A
2-anilineboronic acid pinacol ester
B
4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)aniline
C
3-aminophenylboronic acid pinacolate
Conditions | Yield |
---|---|
With (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 4,4'-di-tert-butyl-2,2'-bipyridine In tetrahydrofuran at 80℃; for 3h; regioselective reaction; |
Conditions | Yield |
---|---|
In chloroform at 20℃; for 1h; regioselective reaction; |
[1,3,2]dioxaborolan-2-yl-phenyl-amine
bis(pinacol)diborane
A
2-anilineboronic acid pinacol ester
B
4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)aniline
C
3-aminophenylboronic acid pinacolate
Conditions | Yield |
---|---|
With (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; triethylamine; 4,4'-di-tert-butyl-2,2'-bipyridine In tetrahydrofuran at 80℃; for 3h; regioselective reaction; |
Conditions | Yield |
---|---|
In chloroform at 20℃; for 1h; regioselective reaction; |
aniline
2-anilineboronic acid pinacol ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: (1,5-cyclooctadiene)(methoxy)iridium(I) dimer / tetrahydrofuran / 0.17 h / 80 °C 2: (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; triethylamine; 4,4'-di-tert-butyl-2,2'-bipyridine / tetrahydrofuran / 12 h / 80 °C 3: chloroform / 1 h / 20 °C View Scheme |
aniline
A
2-anilineboronic acid pinacol ester
B
4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)aniline
C
3-aminophenylboronic acid pinacolate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: (1,5-cyclooctadiene)(methoxy)iridium(I) dimer / tetrahydrofuran / 0.17 h / 80 °C 2: (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; triethylamine; 4,4'-di-tert-butyl-2,2'-bipyridine / tetrahydrofuran / 3 h / 80 °C View Scheme |
[1,3,2]dioxaborolan-2-yl-phenyl-amine
2-anilineboronic acid pinacol ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; triethylamine; 4,4'-di-tert-butyl-2,2'-bipyridine / tetrahydrofuran / 12 h / 80 °C 2: chloroform / 1 h / 20 °C View Scheme |
C6H5NHBO2C2(CH3)4
2-anilineboronic acid pinacol ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; triethylamine; 4,4'-di-tert-butyl-2,2'-bipyridine / tetrahydrofuran / 3 h / 80 °C 2: chloroform / 1 h / 20 °C View Scheme |
nitrobenzene
2-anilineboronic acid pinacol ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: boron trichloride; tris(pentafluorophenyl)borate / 1,2-dichloro-ethane / 6 h / -10 - 50 °C / Inert atmosphere; Sealed tube 2: triethylamine / 1,2-dichloro-ethane / 3 h / 40 °C / pH < 7 3: 5%-palladium/activated carbon; hydrogen / ethyl acetate / 4 h / 80 °C / Inert atmosphere View Scheme |
(diphenylphosphino)phenylamine
4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane
2-anilineboronic acid pinacol ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2 / octane / 6 h / 150 °C / Sealed tube; Inert atmosphere 2: hydrogenchloride / octane; water / 24 h / 20 °C / Inert atmosphere View Scheme |
2-anilineboronic acid pinacol ester
Conditions | Yield |
---|---|
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In 1,4-dioxane; water at 110℃; for 24h; Inert atmosphere; Sealed tube; | 100% |
Conditions | Yield |
---|---|
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In tetrahydrofuran; water at 100℃; for 18h; | 100% |
p-toluenesulfonyl chloride
2-anilineboronic acid pinacol ester
4-methyl-N-(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)benzenesulfonamide
Conditions | Yield |
---|---|
With pyridine at 0 - 25℃; for 3h; | 99% |
In dichloromethane for 18h; Heating; | 33% |
(S)-3-(1-bromovinyl)-2,2-dimethyl-1,4-dioxaspiro[4.4]nonane
2-anilineboronic acid pinacol ester
(R)-2-[1-(3,3-dimethyl-1,4-dioxaspiro[4.4]nonan-2-yl)vinyl]aniline
Conditions | Yield |
---|---|
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In tetrahydrofuran; water at 80℃; for 4h; Suzuki-Miyaura Coupling; | 99% |
2,5-dibromothiophen
2-anilineboronic acid pinacol ester
Conditions | Yield |
---|---|
With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate In 1,4-dioxane; water at 100℃; | 99% |
With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate In 1,4-dioxane for 72h; Suzuki-Miyaura Coupling; Reflux; | 95% |
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In 1,4-dioxane at 100℃; for 72h; Suzuki-Miyaura Coupling; | 77% |
2-anilineboronic acid pinacol ester
Conditions | Yield |
---|---|
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In 1,4-dioxane at 100℃; for 1h; Inert atmosphere; | 99% |
3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl trifluoromethanesulfonate
2-anilineboronic acid pinacol ester
Conditions | Yield |
---|---|
With tetrakis(triphenylphosphine) palladium(0); sodium hydrogencarbonate In 1,2-dimethoxyethane; water at 100℃; for 2h; Inert atmosphere; | 99% |
1,1-bis(diethylphosphono)ethylene
2-anilineboronic acid pinacol ester
C16H29NO6P2
Conditions | Yield |
---|---|
With chloro(1,5-cyclooctadiene)rhodium(I) dimer In 1,4-dioxane; water at 110℃; for 6h; Inert atmosphere; Schlenk technique; | 98% |
2-anilineboronic acid pinacol ester
Boc-(E)-ΔAbu(β-Br)-OMe
3-(tert-butoxycarbonyl)amino-4-methylquinolin-2-one
Conditions | Yield |
---|---|
With caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 In tetrahydrofuran; water at 90℃; for 3h; | 97% |
methyl 2-bromo-3-cyclohexyl-1H-indole-6-carboxylate
2-anilineboronic acid pinacol ester
2-(2-aminophenyl)-3-cyclohexyl-1H-indole-6-carboxylic acid methyl ester
Conditions | Yield |
---|---|
With sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium(0) In 1,2-dimethoxyethane; water for 7h; Suzuki coupling; Heating; | 96% |
With sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium(0) In 1,2-dimethoxyethane; water for 9h; Heating / reflux; | 96% |
With sodium carbonate; bis-triphenylphosphine-palladium(II) chloride In 1,4-dioxane; water at 20 - 100℃; for 78h; | 68% |
2-anilineboronic acid pinacol ester
Conditions | Yield |
---|---|
With [Rh(OH)(cod)]2; potassium carbonate In water at 20℃; for 24h; Microwave irradiation; | 96% |
Conditions | Yield |
---|---|
With tetrakis(triphenylphosphine) palladium(0); sodium hydrogencarbonate In 1,2-dimethoxyethane; water at 100℃; for 4h; Inert atmosphere; | 96% |
2-bromo-3-chloro-5-(trifluoromethyl)pyridine
2-anilineboronic acid pinacol ester
2-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]aniline
Conditions | Yield |
---|---|
With water; sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride In dimethyl sulfoxide for 16h; | 95% |
chloroacetyl chloride
2-anilineboronic acid pinacol ester
N-chloroacetyl-2-aminophenylboronic acid pinacol ester
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile at 20℃; | 95% |
chloroacetyl chloride
2-anilineboronic acid pinacol ester
Conditions | Yield |
---|---|
With K2CO3 In acetonitrile byproducts: KCl; (inert atm.), to K2CO3 in CH3CN added dropwise under stirring 2-amino-phenylboronic acid pinacol ester, treated with 1 equiv. of chloroacetyl chloride dropwise in CH3CN, stirred at room temp. overnight; filtered, washed (CH3CN), evapd.(vac.), tritutated (pentane), dried (vac.), recrystd.; | 95% |
2-anilineboronic acid pinacol ester
Conditions | Yield |
---|---|
In ethyl acetate at 20℃; for 16h; Sealed tube; | 95% |
1-(6-(1-(4-bromo-2,6-dimethylphenylimino)ethyl)pyridin-2-yl)ethanone
2-anilineboronic acid pinacol ester
(4-bromo-2,6-dimethylphenyl)[1-(6-(1-(2-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)phenylimino)ethyl)pyridin-2-yl)ethylidene]amine
Conditions | Yield |
---|---|
In toluene byproducts: H2O; (N2/Ar, Schlenk) a soln. of amine and pyridine-compound in toluene and molecular sieves were kept at 100°C for 3 days; filtered, the solvent was rotary evapd., recrystd. from ethanol; elem. anal.; | 94% |
Conditions | Yield |
---|---|
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In ethanol; water; toluene at 110℃; for 5h; | 94% |
benzalacetophenone
2-anilineboronic acid pinacol ester
2,4-diphenylquinoline
Conditions | Yield |
---|---|
Stage #1: benzalacetophenone; 2-anilineboronic acid pinacol ester With potassium hydroxide; chloro(1,5-cyclooctadiene)rhodium(I) dimer In toluene at 20℃; for 24h; Inert atmosphere; Stage #2: With palladium 10% on activated carbon In toluene for 4h; Reflux; regiospecific reaction; | 93% |
2-chloro-5-methoxybenzaldehyde
2-anilineboronic acid pinacol ester
8-methoxy-phenanthridine
Conditions | Yield |
---|---|
With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; palladium diacetate In dimethyl sulfoxide at 120℃; for 8h; Suzuki Coupling; Inert atmosphere; | 93% |
2-anilineboronic acid pinacol ester
3-(trifluoromethyl)-10,11-dihydro-5H-benzo[b]pyrido[2,3-f]azepine
Conditions | Yield |
---|---|
With chloro(1,5-cyclooctadiene)rhodium(I) dimer; chloro(2-dicyclohexylphosphino-2′,6′-di-i-propoxy-1,1′-biphenyl)(2′-amino-1,1′-biphenyl-2-yl)-palladium(II); potassium hydroxide; XPhos In 1,4-dioxane; water at 110℃; for 16h; Reagent/catalyst; Inert atmosphere; Sealed tube; | 93% |
Multi-step reaction with 2 steps 1: potassium hydroxide; [Rh(cod)OH]2 / Inert atmosphere 2: XPhos; palladium diacetate; sodium t-butanolate / 1,4-dioxane / 16 h / 110 °C / Inert atmosphere View Scheme |
di(4-isocyanatophenyl)methane
2-anilineboronic acid pinacol ester
Conditions | Yield |
---|---|
With triethylamine In tetrahydrofuran at 60℃; for 2h; | 93% |
2-bromoanisole
2-anilineboronic acid pinacol ester
2-(2'-methoxyphenyl)aniline
Conditions | Yield |
---|---|
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In 1,4-dioxane; water at 100℃; for 6h; | 93% |
2-bromothiophene
2-anilineboronic acid pinacol ester
2-(thiophen-2-yl)aniline
Conditions | Yield |
---|---|
Stage #1: 2-bromothiophene; tetrakis(triphenylphosphine) palladium(0) In 1,2-dimethoxyethane for 0.166667h; Stage #2: 2-anilineboronic acid pinacol ester With sodium hydrogencarbonate In 1,2-dimethoxyethane; water at 95℃; for 3h; | 92% |
With sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium(0) In 1,2-dimethoxyethane; water at 95℃; for 3.16667h; | 92% |
3,6-dibromopyridazine
2-anilineboronic acid pinacol ester
2-[6-(2-aminophenyl)pyridazin-3-yl]aniline
Conditions | Yield |
---|---|
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; sodium carbonate In water; N,N-dimethyl-formamide at 20 - 90℃; for 18h; Suzuki coupling; Inert atmosphere; | 92% |
Methyl 2-(2-iodo-1H-indol-3-yl)acetate
2-anilineboronic acid pinacol ester
paullone
Conditions | Yield |
---|---|
With 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; caesium carbonate; copper(l) chloride In N,N-dimethyl-formamide at 80℃; for 2h; Suzuki coupling; Inert atmosphere; | 92% |
2-anilineboronic acid pinacol ester
Conditions | Yield |
---|---|
With tetrakis(triphenylphosphine) palladium(0); sodium hydrogencarbonate In 1,2-dimethoxyethane; water at 90℃; for 24h; Suzuki Coupling; Schlenk technique; Inert atmosphere; | 92% |
With tetrakis(triphenylphosphine) palladium(0); sodium hydrogencarbonate In 1,2-dimethoxyethane at 90℃; for 24h; Suzuki-Miyaura Coupling; Schlenk technique; Inert atmosphere; | 92% |
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