Product Name

  • Name

    2-Chloro-1,1,1-trifluoroethane

  • EINECS
  • CAS No. 75-88-7
  • Article Data68
  • CAS DataBase
  • Density 1.389
  • Solubility
  • Melting Point -105°C
  • Formula C2H2 Cl F3
  • Boiling Point 7°C
  • Molecular Weight 118.486
  • Flash Point
  • Transport Information
  • Appearance
  • Safety A poison by inhalation. Experimental reproductive effects. Questionable carcinogen with experimental carcinogenic data. When heated to decomposition it emits toxic fumes of F.
  • Risk Codes R59
  • Molecular Structure Molecular Structure of 75-88-7 (2-Chloro-1,1,1-trifluoroethane)
  • Hazard Symbols Xi
  • Synonyms (Chloromethyl)trifluoromethane;1,1,1-Trifluoro-2-chloroethane; 1,1,1-Trifluorochloroethane;1,1,1-Trifluoroethyl chloride; 1-Chloro-2,2,2-trifluoroethane;2,2,2-Trifluoro-1-chloroethane; 2,2,2-Trifluorochloroethane;2,2,2-Trifluoroethyl chloride; 2-Chloro-1,1,1-trifluoroethane; F 133a; FC 133a;Forane 133a; Freon 133a; Genetron 133a; HCFC 133a; R 133a
  • PSA 0.00000
  • LogP 1.78750

Synthetic route

Trichloroethylene
79-01-6

Trichloroethylene

1,1,1-trifluoro-2-chloroethane
75-88-7

1,1,1-trifluoro-2-chloroethane

Conditions
ConditionsYield
With hydrogen fluoride; antimony pentafluoride at 100℃; for 1h; Temperature; Autoclave;97%
With hydrogen fluoride; tantalum pentafluoride at 0 - 140℃; under 25858.1 Torr; for 10.5h; Product distribution / selectivity; Neat (no solvent);90%
With hydrogen fluoride; tantalum pentafluoride at 100 - 140℃; under 25858.1 Torr; for 6h;80%
1,1,2,2-tetrachloroethane
79-34-5

1,1,2,2-tetrachloroethane

1,1,1-trifluoro-2-chloroethane
75-88-7

1,1,1-trifluoro-2-chloroethane

Conditions
ConditionsYield
With hydrogen fluoride; antimonypentachloride at 80 - 90℃; Autoclave;92.3%
With hydrogen fluoride; antimonypentachloride; chlorine at 120℃;
1,2-dichloro-1,1-difluoroethane
1649-08-7

1,2-dichloro-1,1-difluoroethane

1,1,1-trifluoro-2-chloroethane
75-88-7

1,1,1-trifluoro-2-chloroethane

Conditions
ConditionsYield
With 1,1,2-trichloro-1-fluoroethane; hydrogen fluoride; tantalum pentachloride at 0 - 140℃; for 2h; Product distribution / selectivity; Neat (no solvent);87.5%
With hydrogen fluoride; tantalum pentachloride at 0 - 140℃; for 2.5h; Product distribution / selectivity; Neat (no solvent);22%
With antimony dichloride trifluoride; hydrogen fluoride at 144℃; under 33097.9 Torr;
2,2,2-trifluoroethanol
75-89-8

2,2,2-trifluoroethanol

trifluoromethane sulfonyl chloride
421-83-0

trifluoromethane sulfonyl chloride

A

1,1,1-trifluoro-2-chloroethane
75-88-7

1,1,1-trifluoro-2-chloroethane

B

1,1,1-trifluoro-2-(2,2,2-trifluoroethoxy)ethane
333-36-8

1,1,1-trifluoro-2-(2,2,2-trifluoroethoxy)ethane

C

2,2,2-trifluoroethyl trifluoromethanesulphonate
6226-25-1

2,2,2-trifluoroethyl trifluoromethanesulphonate

Conditions
ConditionsYield
With potassium carbonate; tetra-n-propylammonium bromide In water at 10.2 - 23.3℃; for 4 - 7h; Product distribution / selectivity;A 0.2 %Chromat.
B 0.13 - 0.28 %Chromat.
C 82%
1,1,1-Trichloro-2,2,2-trifluoroethane
354-58-5

1,1,1-Trichloro-2,2,2-trifluoroethane

1,1,1-trifluoro-2-chloroethane
75-88-7

1,1,1-trifluoro-2-chloroethane

Conditions
ConditionsYield
With ammonium persulfate; ammonium formate In N,N-dimethyl-formamide at 30 - 40℃;77%
1,1,2-trichloro-1-fluoroethane
811-95-0

1,1,2-trichloro-1-fluoroethane

A

1,1,1-trifluoro-2-chloroethane
75-88-7

1,1,1-trifluoro-2-chloroethane

B

1,2-dichloro-1,1-difluoroethane
1649-08-7

1,2-dichloro-1,1-difluoroethane

Conditions
ConditionsYield
With hydrogen fluoride; tantalum pentachloride at 110℃; for 1.5h;A 22%
B 74%
1,1,1-trifluoro-2,2-dichloroethane
306-83-2

1,1,1-trifluoro-2,2-dichloroethane

A

1,1,1-trifluoro-2-chloroethane
75-88-7

1,1,1-trifluoro-2-chloroethane

B

1-Chloro-2,2-difluoroethene
359-10-4

1-Chloro-2,2-difluoroethene

Conditions
ConditionsYield
With water; zinc unter Zusatz eines Netzmittels;
1-Chloro-2,2-difluoroethene
359-10-4

1-Chloro-2,2-difluoroethene

1,1,1-trifluoro-2-chloroethane
75-88-7

1,1,1-trifluoro-2-chloroethane

Conditions
ConditionsYield
With aluminum(III) fluoride; hydrogen fluoride at 300℃;
With hydrogen fluoride; boron trifluoride at 25℃;
Trichloroethylene
79-01-6

Trichloroethylene

A

1,1,1-trifluoro-2-chloroethane
75-88-7

1,1,1-trifluoro-2-chloroethane

B

1,2,2-trichloro-1,2-difluoroethane
354-15-4

1,2,2-trichloro-1,2-difluoroethane

C

1,1,2-Trichloro-1,2,2-trifluoroethane
76-13-1

1,1,2-Trichloro-1,2,2-trifluoroethane

D

CFC-112a
76-12-0

CFC-112a

Conditions
ConditionsYield
With cobalt (III) fluoride at 120℃; Further byproducts given;
chloroacetic acid
79-11-8

chloroacetic acid

A

1,1,1-trifluoro-2-chloroethane
75-88-7

1,1,1-trifluoro-2-chloroethane

B

bis-(2-chloro-1,1-difluoro-ethyl) ether
38217-12-8

bis-(2-chloro-1,1-difluoro-ethyl) ether

Conditions
ConditionsYield
With sulfur tetrafluoride at 65℃; for 3h;
Chloroiodomethane
593-71-5

Chloroiodomethane

iodotrifluoromethane
2314-97-8

iodotrifluoromethane

1,1,1-trifluoro-2-chloroethane
75-88-7

1,1,1-trifluoro-2-chloroethane

Conditions
ConditionsYield
Ambient temperature; Irradiation; Hg2I2, Hg;
Vinylidene fluoride
75-38-7

Vinylidene fluoride

trifluoromethyl hypochlorite
22082-78-6

trifluoromethyl hypochlorite

A

1,1,1-trifluoro-2-chloroethane
75-88-7

1,1,1-trifluoro-2-chloroethane

B

Trifluormethyl-1,1-difluor-2-chloraethylaether
25957-33-9

Trifluormethyl-1,1-difluor-2-chloraethylaether

Conditions
ConditionsYield
In trichlorofluoromethane at -111 - 22℃; for 20h; Product distribution; various temperatures, olefins, solvents and times;A 50 % Spectr.
B 50 % Spectr.
In trichlorofluoromethane at -111 - 22℃; for 20h; Yield given. Title compound not separated from byproducts;
Vinylidene fluoride
75-38-7

Vinylidene fluoride

A

1,1,1-trifluoro-2-chloroethane
75-88-7

1,1,1-trifluoro-2-chloroethane

B

Trifluormethyl-1,1-difluor-2-chloraethylaether
25957-33-9

Trifluormethyl-1,1-difluor-2-chloraethylaether

Conditions
ConditionsYield
With trifluoromethyl hypochlorite In trichlorofluoromethane at -111 - 22℃; for 20h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
Trichloroethylene
79-01-6

Trichloroethylene

A

1,1,1,2-tetrafluoroethane
811-97-2

1,1,1,2-tetrafluoroethane

B

1,1,1-trifluoro-2-chloroethane
75-88-7

1,1,1-trifluoro-2-chloroethane

Conditions
ConditionsYield
With hydrogen fluoride; chromium(III) oxide at 250℃; Mechanism; Product distribution; hydrofluorination, chlorine/fluorine exchange mechanism; effect of DF substitution for HF;A 10 % Chromat.
B 90 % Chromat.
With chromium(III) oxide; hydrogen fluoride at 653℃; for 18h; Product distribution; Further Variations:; Temperatures; Fluorination; Addition; Substitution;
With chromium fluoride; magnesium fluoride; hydrogen fluoride at 200℃; under 7600 Torr; Product distribution; Further Variations:; Pressures;
1,1,1-trifluoro-2-bromo-2-chloroethane
151-67-7

1,1,1-trifluoro-2-bromo-2-chloroethane

A

1,1,1-trifluoro-2-chloroethane
75-88-7

1,1,1-trifluoro-2-chloroethane

B

1-Chloro-2,2-difluoroethene
359-10-4

1-Chloro-2,2-difluoroethene

Conditions
ConditionsYield
With perchloric acid; CoW7-; sodium perchlorate In water; acetonitrile at 20℃; Rate constant; Product distribution; pH 7; reaction with Co(II)sepuchrate2- at 50 deg C; electron transfer reactions of polyhaloalkanes with Co(II)W12O407- and Co(II)sepulchrate2+, order of reactivity toward Co(II)W12O407-, trapping experiments with N-t-butyl-α-phenylnitrone;
With liver microsomes Enzyme kinetics; Enzymatic reaction;
1,1,1-trifluoro-2-chloroethyl radical
28760-99-8

1,1,1-trifluoro-2-chloroethyl radical

1,1,1-trifluoro-2-chloroethane
75-88-7

1,1,1-trifluoro-2-chloroethane

Conditions
ConditionsYield
With isopropyl alcohol
3-chloro-3-(trifluoromethyl)diazirine
58911-30-1

3-chloro-3-(trifluoromethyl)diazirine

A

1,1,1-trifluoro-2-chloroethane
75-88-7

1,1,1-trifluoro-2-chloroethane

B

Chlorotrifluoroethylene
79-38-9

Chlorotrifluoroethylene

Conditions
ConditionsYield
Irradiation;
Irradiation; radiation > 300 nm;
1,1,1-Trichloro-2,2,2-trifluoroethane
354-58-5

1,1,1-Trichloro-2,2,2-trifluoroethane

A

1,1,1-trifluoro-2-chloroethane
75-88-7

1,1,1-trifluoro-2-chloroethane

B

1,1,1-trifluoro-2,2-dichloroethane
306-83-2

1,1,1-trifluoro-2,2-dichloroethane

Conditions
ConditionsYield
With hydrogen; RhCl(PPh3)3 In tetrahydrofuran at 100℃; under 6080 Torr; for 5h; Product distribution; further catalysts and times; effect of bases;A 3.5 % Chromat.
B 94.6 % Chromat.
With hydrogen; RhCl(PPh3)3 In tetrahydrofuran at 100℃; under 6080 Torr; for 5h;A 3.5 % Chromat.
B 94.6 % Chromat.
1,1,1-trifluoro-2,2-dichloroethane
306-83-2

1,1,1-trifluoro-2,2-dichloroethane

benzaldehyde
100-52-7

benzaldehyde

A

1,1,1-trifluoro-2-chloroethane
75-88-7

1,1,1-trifluoro-2-chloroethane

B

1-Chloro-2,2-difluoroethene
359-10-4

1-Chloro-2,2-difluoroethene

C

2-chloro-3,3-difluoro-1-phenyl-2-propenol
67230-92-6

2-chloro-3,3-difluoro-1-phenyl-2-propenol

D

1-(α,α-dichloro-β,β,β-trifluoroethyl)benzylalcohol
103654-96-2, 121591-61-5, 121591-67-1

1-(α,α-dichloro-β,β,β-trifluoroethyl)benzylalcohol

E

2-chloro-1,1,1-trifluoro-3-phenylpropan-3-ol
138950-21-7

2-chloro-1,1,1-trifluoro-3-phenylpropan-3-ol

Conditions
ConditionsYield
With zinc; copper(l) chloride In N,N-dimethyl-formamide Product distribution; Mechanism; Ambient temperature; various concentrations; without catalyst; further aldehydes;A 24 % Spectr.
B 20 % Spectr.
C 37 % Spectr.
D 3 % Spectr.
E 12 % Spectr.
1,1,1-trifluoro-2,2-dichloroethane
306-83-2

1,1,1-trifluoro-2,2-dichloroethane

benzaldehyde
100-52-7

benzaldehyde

A

1,1,1-trifluoro-2-chloroethane
75-88-7

1,1,1-trifluoro-2-chloroethane

B

2-chloro-3,3-difluoro-1-phenyl-2-propenol
67230-92-6

2-chloro-3,3-difluoro-1-phenyl-2-propenol

C

1-(α,α-dichloro-β,β,β-trifluoroethyl)benzylalcohol
103654-96-2, 121591-61-5, 121591-67-1

1-(α,α-dichloro-β,β,β-trifluoroethyl)benzylalcohol

D

2-chloro-1,1,1-trifluoro-3-phenylpropan-3-ol
138950-21-7

2-chloro-1,1,1-trifluoro-3-phenylpropan-3-ol

Conditions
ConditionsYield
With zinc; copper(l) chloride 1.) DMF, 24 h; 2.) DMF; Yield given. Multistep reaction. Yields of byproduct given;
tris(2,2,2-trifluoroethyl)phosphite
370-69-4

tris(2,2,2-trifluoroethyl)phosphite

chloral
75-87-6

chloral

A

1,1,1-trifluoro-2-chloroethane
75-88-7

1,1,1-trifluoro-2-chloroethane

B

Phosphoric acid 2,2-dichloro-vinyl ester bis-(2,2,2-trifluoro-ethyl) ester

Phosphoric acid 2,2-dichloro-vinyl ester bis-(2,2,2-trifluoro-ethyl) ester

Conditions
ConditionsYield
Heating;
1,1,1-trifluoro-2-chloroethane
75-88-7

1,1,1-trifluoro-2-chloroethane

2,2,2-trifluoroethanol
75-89-8

2,2,2-trifluoroethanol

1,1,1-trifluoro-2-(2,2,2-trifluoroethoxy)ethane
333-36-8

1,1,1-trifluoro-2-(2,2,2-trifluoroethoxy)ethane

Conditions
ConditionsYield
With potassium hydroxide In 1,2-dimethoxyethane at 70℃; for 4h; Temperature;97.4%
1,1,1-trifluoro-2-chloroethane
75-88-7

1,1,1-trifluoro-2-chloroethane

2,2,2-trifluoroethanol
75-89-8

2,2,2-trifluoroethanol

Conditions
ConditionsYield
With potassium γ-hydroxybutyrate In 4-butanolide at 200℃; under 11251.1 Torr; for 6h;96%
With 4-butanolide; potassium hydroxide at 200℃; under 11251.1 Torr; for 6h;68%
With potassium acetate; ethylene glycol; acetic acid
1,1,1-trifluoro-2-chloroethane
75-88-7

1,1,1-trifluoro-2-chloroethane

trifluoroethylamine
753-90-2

trifluoroethylamine

Conditions
ConditionsYield
With dmap; ammonia at 110℃; Temperature;94%
With ammonia; water at 190℃;
With ammonia; water at 185℃;
1,1,1-trifluoro-2-chloroethane
75-88-7

1,1,1-trifluoro-2-chloroethane

p-bromophenylboronic acid pinacol ester
68716-49-4

p-bromophenylboronic acid pinacol ester

4,4,5,5-tetramethyl-2-(4-(2,2,2-trifluoroethyl)phenyl)-1,3,2-dioxaborolane
1310949-87-1

4,4,5,5-tetramethyl-2-(4-(2,2,2-trifluoroethyl)phenyl)-1,3,2-dioxaborolane

Conditions
ConditionsYield
With 4,4'-di-tert-butyl-2,2'-bipyridine; magnesium chloride; nickel dibromide; zinc In N,N-dimethyl acetamide at 80℃; for 12h; Inert atmosphere; Schlenk technique;94%
1,1,1-trifluoro-2-chloroethane
75-88-7

1,1,1-trifluoro-2-chloroethane

(3-bromophenyl)trimethylsilane
17878-47-6

(3-bromophenyl)trimethylsilane

trimethyl(3-(2,2,2-trifluoroethyl)phenyl)silane

trimethyl(3-(2,2,2-trifluoroethyl)phenyl)silane

Conditions
ConditionsYield
With 4,4'-di-tert-butyl-2,2'-bipyridine; magnesium chloride; nickel dibromide; zinc In N,N-dimethyl acetamide at 80℃; for 12h; Inert atmosphere; Schlenk technique;93%
1,1,1-trifluoro-2-chloroethane
75-88-7

1,1,1-trifluoro-2-chloroethane

mercury dichloride

mercury dichloride

chloro(chlorodifluorovinyl)mercury

chloro(chlorodifluorovinyl)mercury

Conditions
ConditionsYield
With BuLi In tetrahydrofuran; diethyl ether (N2); BuLi slowly added to stirred soln. of ligand (1 equiv.) in Et2O at-80°C; react. temp. was maintained between -55°C and -80. degree.C for 2 h; HgCl2 (1 equiv.) in THF added at -110°C; warmedto -35°C for few h; warmed to room temp.; solvent vol. reduced in vac. to half; hexane added; mixt. was allowed to settle; filtered under N2; solvent removed in vac.; washed (hexane); elem. anal.;87%
1,1,1-trifluoro-2-chloroethane
75-88-7

1,1,1-trifluoro-2-chloroethane

naphthalene-2-boronic acid
32316-92-0

naphthalene-2-boronic acid

2-(2,2,2-trifluoroethyl)naphthalene
1204295-99-7

2-(2,2,2-trifluoroethyl)naphthalene

Conditions
ConditionsYield
With [2,2]bipyridinyl; nickel(II) bromide dimethoxyethane; potassium phosphate In dimethyl sulfoxide at 80℃; for 30h; Inert atmosphere; Sealed tube;87%
1,1,1-trifluoro-2-chloroethane
75-88-7

1,1,1-trifluoro-2-chloroethane

potassium acetate
127-08-2

potassium acetate

4,4,4-trifluorobutyric acid
406-93-9

4,4,4-trifluorobutyric acid

Conditions
ConditionsYield
Stage #1: 1,1,1-trifluoro-2-chloroethane; potassium acetate In 1-methyl-pyrrolidin-2-one at 180℃; for 23h; Autoclave; Sealed tube;
Stage #2: With acetic anhydride In 1-methyl-pyrrolidin-2-one at 35 - 40℃; for 3h; Reagent/catalyst; Solvent;
86.5%
1,1,1-trifluoro-2-chloroethane
75-88-7

1,1,1-trifluoro-2-chloroethane

1-Bromo-3-iodobenzene
591-18-4

1-Bromo-3-iodobenzene

1-bromo-2-(1-chloro-2,2-difluoro-vinyl)-benzene

1-bromo-2-(1-chloro-2,2-difluoro-vinyl)-benzene

Conditions
ConditionsYield
Stage #1: 1,1,1-trifluoro-2-chloroethane With n-butyllithium; diisopropylamine; zinc(II) chloride In tetrahydrofuran at 15 - 20℃; for 2h;
Stage #2: 1-Bromo-3-iodobenzene With tetrakis(triphenylphosphine) palladium(0) at 20℃; for 18h;
85%
1,1,1-trifluoro-2-chloroethane
75-88-7

1,1,1-trifluoro-2-chloroethane

1-Bromo-3-iodobenzene
591-18-4

1-Bromo-3-iodobenzene

A

m-bromo-α-chloro-β,β-styrene

m-bromo-α-chloro-β,β-styrene

B

1,4-bis-(1-chloro-2,2-difluoro-vinyl)-benzene

1,4-bis-(1-chloro-2,2-difluoro-vinyl)-benzene

Conditions
ConditionsYield
Stage #1: 1,1,1-trifluoro-2-chloroethane With zinc(II) chloride; lithium diisopropyl amide In tetrahydrofuran at 20℃; for 2h;
Stage #2: 1-Bromo-3-iodobenzene; tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran at 20℃; for 18h;
A 85%
B 1%
1,1,1-trifluoro-2-chloroethane
75-88-7

1,1,1-trifluoro-2-chloroethane

4-methoxyphenylboronic acid
5720-07-0

4-methoxyphenylboronic acid

1-methoxy-4-(2,2,2-trifluoroethyl)benzene
157928-44-4

1-methoxy-4-(2,2,2-trifluoroethyl)benzene

Conditions
ConditionsYield
With [2,2]bipyridinyl; nickel(II) bromide dimethoxyethane; potassium phosphate In dimethyl sulfoxide at 80℃; for 30h; Inert atmosphere; Sealed tube;85%
1,1,1-trifluoro-2-chloroethane
75-88-7

1,1,1-trifluoro-2-chloroethane

fenofibrate
49562-28-9

fenofibrate

isopropyl 2-methyl-2-(4-(4-(2,2,2-trifluoroethyl)benzoyl)phenoxy)propanoate

isopropyl 2-methyl-2-(4-(4-(2,2,2-trifluoroethyl)benzoyl)phenoxy)propanoate

Conditions
ConditionsYield
With 4,4'-di-tert-butyl-2,2'-bipyridine; magnesium chloride; nickel dibromide; zinc In N,N-dimethyl acetamide at 80℃; for 12h; Inert atmosphere; Schlenk technique;85%
1,1,1-trifluoro-2-chloroethane
75-88-7

1,1,1-trifluoro-2-chloroethane

tributyltin chloride
1461-22-9

tributyltin chloride

tributyl(chlorodifluorovinyl)tin
214422-68-1

tributyl(chlorodifluorovinyl)tin

Conditions
ConditionsYield
With BuLi In diethyl ether BuLi added to soln. of ligand in Et2O at -80°C; after 2 h soln. of Bu3SnCl in Et2O (dissolved at -80°C) added slowly at -110°C; warmed to room temp. overnight; hexane added; filtered; solvent removed on rotary evaporator; distd. in vac. (242°C, 0.2 mmHg); elem. anal.;84%
1,1,1-trifluoro-2-chloroethane
75-88-7

1,1,1-trifluoro-2-chloroethane

triethyltin bromide
2767-54-6

triethyltin bromide

triethyl(chlorodifluorovinyl)tin
329911-50-4

triethyl(chlorodifluorovinyl)tin

Conditions
ConditionsYield
With BuLi In diethyl ether (N2); BuLi added to soln. of ligand in Et2O at -80°C; after 2 h soln. of Et3SnBr in Et2O (dissolved at -80°C) added slowly at -110°C; warmed to room temp. overnight; hexane added; filtered; solvent removed on rotary evaporator; distd. in vac. (182°C, 0.2 mmHg); elem. anal.;84%
1,1,1-trifluoro-2-chloroethane
75-88-7

1,1,1-trifluoro-2-chloroethane

4-tolyl iodide
624-31-7

4-tolyl iodide

4-methyl-α-chloro-β,β-difluorostyrene

4-methyl-α-chloro-β,β-difluorostyrene

Conditions
ConditionsYield
Stage #1: 1,1,1-trifluoro-2-chloroethane With n-butyllithium; diisopropylamine; zinc(II) chloride In tetrahydrofuran at 15 - 20℃; for 2h;
Stage #2: 4-tolyl iodide With tetrakis(triphenylphosphine) palladium(0) at 20℃; for 12h;
83%
Stage #1: 1,1,1-trifluoro-2-chloroethane With zinc(II) chloride; lithium diisopropyl amide In tetrahydrofuran at 20℃; for 2h;
Stage #2: 4-tolyl iodide; tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran at 20℃; for 12h;
83%
1,1,1-trifluoro-2-chloroethane
75-88-7

1,1,1-trifluoro-2-chloroethane

9H-carbazole
86-74-8

9H-carbazole

9-(2,2,2-trifluoroethyl)-9H-carbazole

9-(2,2,2-trifluoroethyl)-9H-carbazole

Conditions
ConditionsYield
With caesium carbonate In N,N-dimethyl-formamide for 16h; Inert atmosphere;83%
1,1,1-trifluoro-2-chloroethane
75-88-7

1,1,1-trifluoro-2-chloroethane

1-bromo-4-tert-butylbenzene
3972-65-4

1-bromo-4-tert-butylbenzene

1-(tert-butyl)-4-(2,2,2-trifluoroethyl)benzene
1099597-89-3

1-(tert-butyl)-4-(2,2,2-trifluoroethyl)benzene

Conditions
ConditionsYield
With 4,4'-di-tert-butyl-2,2'-bipyridine; magnesium chloride; nickel dibromide; zinc In N,N-dimethyl acetamide at 80℃; for 12h; Inert atmosphere; Schlenk technique;83%
N-TBS-4-bromoindole
193694-04-1

N-TBS-4-bromoindole

1,1,1-trifluoro-2-chloroethane
75-88-7

1,1,1-trifluoro-2-chloroethane

1-(tert-butyldimethylsilyl)-4-(2,2,2-trifluoroethyl)-1H-indole

1-(tert-butyldimethylsilyl)-4-(2,2,2-trifluoroethyl)-1H-indole

Conditions
ConditionsYield
With 4,4'-di-tert-butyl-2,2'-bipyridine; magnesium chloride; nickel dibromide; zinc In N,N-dimethyl acetamide at 80℃; for 20h; Inert atmosphere; Schlenk technique;83%
1,1,1-trifluoro-2-chloroethane
75-88-7

1,1,1-trifluoro-2-chloroethane

N-(ethoxycarbonylmethyl)pyridinium bromide
17282-40-5

N-(ethoxycarbonylmethyl)pyridinium bromide

2-fluoro-indolizine-3-carboxylic acid ethyl ester

2-fluoro-indolizine-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
With potassium carbonate; triethylamine In N,N-dimethyl-formamide at 80℃; for 24h;82%

1,1,1-Trifluoro-2-chloroethane Chemical Properties

Molecular Structure of 1,1,1-Trifluoro-2-chloroethane (CAS NO.75-88-7):

EINECS: 200-912-0
IUPAC Name: 2-Chloro-1,1,1-trifluoroethane 
Molecular Formula: C2H2ClF3
Molecular Weight: 118.485490 g/mol
XLogP3-AA: 1.9
H-Bond Donor: 0
H-Bond Acceptor: 3
Canonical SMILES: C(C(F)(F)F)Cl
InChI: InChI=1S/C2H2ClF3/c3-1-2(4,5)6/h1H2
InChIKey: CYXIKYKBLDZZNW-UHFFFAOYSA-N
Index of Refraction: 1.298
Molar Refractivity: 16.62 cm3
Molar Volume: 89.3 cm3
Surface Tension: 14.3 dyne/cm
Density: 1.326 g/cm3
Enthalpy of Vaporization: 24.48 kJ/mol
Boiling Point: 6.9 °C at 760 mmHg
Vapour Pressure: 1430 mmHg at 25 °C
Melting Point: -105 °C
Water Solubility: 365.4 mg/L at 25 °C
BRN: 1733200

1,1,1-Trifluoro-2-chloroethane Toxicity Data With Reference

1.    

orl-rat TDLo:78 g/kg/1Y-I:CAR,REP

    TXAPA9    Toxicology and Applied Pharmacology. 72 (1984),15.
2.    

ihl-mus LC50:15 pph/1H

    BJANAD    British Journal of Anesthesia. 37 (1965),716.

1,1,1-Trifluoro-2-chloroethane Consensus Reports

IARC Cancer Review: Group 3 IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 ,1987,p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Limited Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 41 ,1986,p. 253.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . Reported in EPA TSCA Inventory.

1,1,1-Trifluoro-2-chloroethane Safety Profile

Safety Information of 1,1,1-Trifluoro-2-chloroethane (CAS NO.75-88-7):
Hazard Codes: Xi Irritant
Hazard Note: Irritant
Risk Statements: 59
R59:Dangerous to the ozone layer
Safety Statements: 9-23-59
S9:Keep container in a well-ventilated place
S23:Do not breathe vapour
S59:Refer to manufacturer / supplier for information on recovery / recycling
RIDADR: 1983
TSCA: T
HazardClass: 2.2
A poison by inhalation. Experimental reproductive effects. Questionable carcinogen with experimental carcinogenic data. When heated to decomposition it emits toxic fumes of F.

1,1,1-Trifluoro-2-chloroethane Specification

  1,1,1-Trifluoro-2-chloroethane with CAS Registry Number of 75-88-7 is a colorless, odorless gas. It is also known as 1,1,1-Trifluoroethyl chloride ; 1-Chloro-2,2,2-trifluoroethane ; 2,2,2-Trifluorochloroethane ; 2-Chloro-1,1,1-trifluoroethane ; 4-01-00-00128 (Beilstein Handbook Reference) ; CCRIS 154 ; CFC 133a ; FC 133a ; Forane 133a ; Freon 133a ; Genetron 133a ; HCFC 133a ; HCFC-133a ; HSDB 6949 ; R 133a ; Chloro-1,1,1-trifluoroethane ; Ethane, 2-chloro-1,1,1-trifluoro- ; 1-Chloro-2,2,2-trifluoroethane or Refrigerant gas R 133a [UN1983] [Non-flammable gas] ; Chlorotrifluoroethane ; HCFC-133a ; UN1983 . It can react violently with strong reducing agents and undergo oxidation with strong oxidizing agents and under extremes of temperature.

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