1,2,4-TRIMETHYL BENZENE supplier

Name
1,2,4-Trimethylbenzene
EINECS 202-436-9
CAS No. 95-63-6
Article Data174
CAS DataBase
Density 0.869 g/cm³
Solubility Soluble in alcohol, benzene and ether. Slightly soluble in water
Melting Point -44 °C
Formula C₉H₁₂
Boiling Point 170.8 °C at 760 mmHg
Molecular Weight 120.194
Flash Point 48.9 °C
Transport Information UN 3295 3/PG 3
Appearance clear liquid
Safety 26-61-45-36/37-16-7
Risk Codes 10-20-36/37/38-51/53-39/23/24/25-23/24/25-11
Molecular Structure
Hazard Symbols Xn, N, F, T, Xi
Synonyms 1,2,5-Trimethylbenzene;1,3,4-Trimethylbenzene;Methyl-p-xylene;NSC 65600;Pseudocumene;Pseudocumol;pseudo-Cumene;y-Cumene;
PSA 0.00000
LogP 2.61180

Synthetic route

: 5973-71-7
3,4-dimethylbenzaldehyde

A: 95-47-6
o-xylene

B: 95-63-6
1,2,4-Trimethylbenzene

Conditions

Conditions	Yield
With palladium/alumina; hydrogen In hexane at 325℃; Flow reactor; Green chemistry;	A 96.2% B 3.8%
With hydrogen In hexane at 325℃; Flow reactor; Green chemistry;	A 15.9% B 84.2%

: 513-81-5
2,3-dimethyl-buta-1,3-diene

: 123-73-9
crotonaldehyde

: 95-63-6
1,2,4-Trimethylbenzene

Conditions

Conditions	Yield
Stage #1: 2,3-dimethyl-buta-1,3-diene; crotonaldehyde at 150℃; for 3h; Diels-Alder Cycloaddition; Stage #2: With 5%-palladium/activated carbon In ethyl acetate at 260℃;	95%

: 312609-91-9
2,3,5-Trimethyl-(4-methylphenylsulfonyloxy)benzene

: 95-63-6
1,2,4-Trimethylbenzene

Conditions

Conditions	Yield
With sodium tetrahydroborate; bis(triphenylphosphine)nickel(II) chloride; tricyclohexylphosphine In tetrahydrofuran at 60℃; for 14h;	93%

: 74-99-7
prop-1-yne

: 95-63-6
1,2,4-Trimethylbenzene

Conditions

Conditions	Yield
With (η4-1,5-hexadiene)(1,3-bis(2,6-diisopropylphenyl)-1,3-dihydro-2H-imidazol-2-ylidene)nickel In BENZENE-d6 at 20℃;	91%

: 854432-99-8
triplal

A: 106-42-3
para-xylene

B: 95-63-6
1,2,4-Trimethylbenzene

Conditions

Conditions	Yield
With palladium/alumina; hydrogen In hexane at 325℃; Flow reactor; Green chemistry;	A 84.8% B 6.5%
With hydrogen In hexane at 325℃; Flow reactor; Green chemistry;	A 19.5% B 73.2%

: 18022-66-7
3,4-dimethylcyclohex-3-ene-1-carboxaldehyde

A: 95-47-6
o-xylene

B: 95-63-6
1,2,4-Trimethylbenzene

Conditions

Conditions	Yield
With hydrogen In hexane at 325℃; Flow reactor; Green chemistry;	A 17.5% B 80.9%
With palladium/alumina; hydrogen In hexane at 325℃; Flow reactor; Green chemistry;	A 73% B 27%

: 824-55-5
2,4-dimethyl-benzyl chloride

: 95-63-6
1,2,4-Trimethylbenzene

Conditions

Conditions	Yield
With sodium tetrahydroborate; (-) In ethanol at 20℃; for 2h;	63%
With phosphorus; hydrogen iodide
With diethyl ether; magnesium Zersetzen der Reaktionsprodukte mit Wasser;

: CpZr{(Me)CCHC(Me)CH}(dmpe)Cl

: 74-99-7
prop-1-yne

A: 95-63-6
1,2,4-Trimethylbenzene

B: 108-67-8
1,3,5-trimethyl-benzene

Conditions

Conditions	Yield
In benzene-d6 1 turnover/day, catalytic react., 25°C; products detd. by NMR and GC;	A 45% B 55%

...Expand

: 95-47-6
o-xylene

A: 611-14-3
2-Ethyltoluene

B: 95-63-6
1,2,4-Trimethylbenzene

C: 526-73-8
1,2,3-trimethylbenzene

D: 89-95-2
2-methyl-benzyl alcohol

E: 952-80-7
1,2-bis(2-methylphenyl)ethane

Conditions

Conditions	Yield
With peracetic acid at 20 - 22℃; Product distribution; Irradiation; λ>2900 Angstroem;	A 9.3% B n/a C n/a D 36.9% E n/a

...Expand

: 106-42-3
para-xylene

A: 589-18-4
4-Methylbenzyl alcohol

B: 95-63-6
1,2,4-Trimethylbenzene

C: 622-96-8
4-methylethylbenzene

D: 538-39-6
1,2-di-p-tolylethane

Conditions

Conditions	Yield
With peracetic acid at 20 - 22℃; Product distribution; Irradiation; λ>2900 Angstroem;	A 32.3% B 5.9% C 10.2% D n/a

...Expand

: 108-38-3
m-xylene

A: 620-14-4
1-Methyl-3-ethylbenzene

B: 95-63-6
1,2,4-Trimethylbenzene

C: 526-73-8
1,2,3-trimethylbenzene

D: 4662-96-8
1,2-di-m-tolylethane

E: 587-03-1
3-methylbenzyl alcohol

F: 108-67-8
1,3,5-trimethyl-benzene

Conditions

Conditions	Yield
With peracetic acid at 20 - 22℃; Product distribution; Irradiation; λ>2900 Angstroem;	A 7.4% B n/a C n/a D n/a E 30% F n/a

...Expand

: 95-47-6
o-xylene

A: 95-65-8
3,4-Dimethylphenol

B: 611-14-3
2-Ethyltoluene

C: 95-63-6
1,2,4-Trimethylbenzene

D: 526-75-0
2,3-Dimethylphenol

E: 89-95-2
2-methyl-benzyl alcohol

F: 952-80-7
1,2-bis(2-methylphenyl)ethane

Conditions

Conditions	Yield
With peracetic acid at 20 - 22℃; Product distribution; Irradiation; λ=2537 Angstroem;	A n/a B 24.3% C n/a D n/a E 15.1% F n/a

...Expand

: 106-42-3
para-xylene

A: 95-87-4
2,5-Dimethylphenol

B: 589-18-4
4-Methylbenzyl alcohol

C: 95-63-6
1,2,4-Trimethylbenzene

D: 622-96-8
4-methylethylbenzene

E: 538-39-6
1,2-di-p-tolylethane

Conditions

Conditions	Yield
With peracetic acid at 20 - 22℃; Product distribution; Irradiation; λ=2537 Angstroem;	A 6.1% B 13.5% C 8.4% D 23.5% E n/a

...Expand

: 67-64-1
acetone

A: 74-84-0
ethane

B: 74-98-6
propane

C: 95-47-6
o-xylene

D: 95-63-6
1,2,4-Trimethylbenzene

E: 108-88-3
toluene

F: 71-43-2
benzene

G Mixture of alkanes C4,C5 and m,p-Xylenes and O-compounds: Mixture of alkanes C4,C5 and m,p-Xylenes and O-compounds

Conditions

Conditions	Yield
Zeolite HZSM-5(1) at 350℃; under 760 Torr; for 1h; Product distribution; Mechanism; 1)other times 2)other zeolites 3) impregnation of zeolites with basic oxides;	A 3.4% B 8.1% C 11% D 7.8% E 15.4% F 3.7% G n/a

...Expand

: 106-42-3
para-xylene

A: 95-47-6
o-xylene

B: 95-63-6
1,2,4-Trimethylbenzene

C: 108-38-3
m-xylene

D: 108-88-3
toluene

Conditions

Conditions	Yield
Product distribution; Irradiation; other xylene, also with DCA;	A 0.4% B 13.2% C 1.2% D 5%

...Expand

: 56-23-5
tetrachloromethane

: 50-00-0
formaldehyd

: 95-63-6
1,2,4-Trimethylbenzene

Conditions

Conditions	Yield
With hydrogenchloride at 50 - 60℃; Einleiten von HCl, Kochen des Reaktionsprodukts mit aethanol. NaOH und Hydrogenolyse des gebildeten Aethylaether-Gemisches an Kupferchromit bei 300grad unter Druck;

: 56-23-5
tetrachloromethane

: 74-87-3
methylene chloride

: 95-63-6
1,2,4-Trimethylbenzene

Conditions

Conditions	Yield
With aluminium trichloride at 95℃;

: 56-23-5
tetrachloromethane

: 95-63-6
1,2,4-Trimethylbenzene

Conditions

Conditions	Yield
With aluminium trichloride at 130 - 140℃;

: 50-00-0
formaldehyd

: 95-47-6
o-xylene

: 95-63-6
1,2,4-Trimethylbenzene

Conditions

Conditions	Yield
With hydrogenchloride Erwaermen der Reaktionsprodukte mit Zinkstaub und wss. NaOH auf 100grad;
With hydrogenchloride Erwaermen der Reaktionsprodukte mit Zinkstaub und wss. NaOH auf 100grad;

: 50-00-0
formaldehyd

: 106-42-3
para-xylene

: 95-63-6
1,2,4-Trimethylbenzene

Conditions

Conditions	Yield
With hydrogenchloride Erwaermen der Reaktionsprodukte mit Zinkstaub und wss. NaOH auf 100grad;
With hydrogenchloride Erwaermen der Reaktionsprodukte mit Zinkstaub und wss. NaOH auf 100grad;

: 78-59-1
3,5,5-Trimethylcyclohex-2-en-1-one

: 95-63-6
1,2,4-Trimethylbenzene

Conditions

Conditions	Yield
With phosphorus pentoxide

: 74-87-3
methylene chloride

: 95-47-6
o-xylene

: 95-63-6
1,2,4-Trimethylbenzene

Conditions

Conditions	Yield
With aluminium trichloride at 80℃;

: 504-20-1
phorone

: 95-63-6
1,2,4-Trimethylbenzene

Conditions

Conditions	Yield
With phosphorus pentaoxide
With zinc(II) chloride
With phosphorus pentoxide

: 504-20-1
phorone

A: 95-63-6
1,2,4-Trimethylbenzene

B: 108-67-8
1,3,5-trimethyl-benzene

Conditions

Conditions	Yield
With phosphorus pentoxide
With zinc(II) chloride

: 64-17-5
ethanol

: nitroso-(2,4,5-trimethyl-phenyl)-amidosulfuric acid

: 95-63-6
1,2,4-Trimethylbenzene

Conditions

Conditions	Yield
unter geringem Ueberdruck;

: 3073-66-3, 150927-19-8, 150927-30-3
1,1,3-trimethylcyclohexane

: 95-63-6
1,2,4-Trimethylbenzene

Conditions

Conditions	Yield
With Pt/Al2O3; hydrogen at 300℃;
With Pt/Al2O3; s-butyl chloride at 300℃;

: 32588-46-8
bis-(2,4-dimethyl-phenyl)methane

: 95-63-6
1,2,4-Trimethylbenzene

Conditions

Conditions	Yield
With hydrogen; nickel; tungsten at 450℃; under 13974.6 Torr;
With molybdenum oxide-aluminium oxide; hydrogen at 300℃;

: 824-45-3
2,5-dimethylbenzyl chloride

: 95-63-6
1,2,4-Trimethylbenzene

Conditions

Conditions	Yield
With tetrahydrofuran; lithium aluminium tetrahydride; lithium hydride
With diethyl ether; magnesium Zersetzen der Reaktionsprodukte mit Wasser;

: 137-17-7
2,4,5-trimethylaniline

: 95-63-6
1,2,4-Trimethylbenzene

Conditions

Conditions	Yield
Diazotization.Reduktion mit Zinn in alkal. Loesung;

: 6784-16-3
5-methyl-2-isopropylidenecyclopentanone

: 95-63-6
1,2,4-Trimethylbenzene

Conditions

Conditions	Yield
With phosphorus pentoxide

: 95-63-6
1,2,4-Trimethylbenzene

: 90326-72-0
1,2,4-tribromo-3,5,6-trimethyl-benzene

Conditions

Conditions	Yield
With benzyltrimethylazanium tribroman-2-uide; zinc(II) chloride In acetic acid at 70℃; for 24h;	99%

: 95-63-6
1,2,4-Trimethylbenzene

: 5469-19-2
1-bromo-2,4,5-trimethylbenzene

Conditions

Conditions	Yield
With sulfuric acid; dihydrogen peroxide; iodine; iron(II) sulfate; sodium bromide In dichloromethane; water at 0℃;	97.3%
With hydrogenchloride; sodium hypochlorite; sodium bromide In water at 29.85℃; for 8h; Product distribution; Further Variations:; Temperatures;	96.2%
With bromine; iron; acetic acid

: 95-63-6
1,2,4-Trimethylbenzene

: 2100-23-4
1-iodo-2,4,5-trimethylbenzene

Conditions

Conditions	Yield
With N,N,N-trimethylbenzenemethanaminium dichloroiodate; zinc(II) chloride In acetic acid for 48h; Ambient temperature;	97%
With iodine; Selectfluor In acetonitrile at 55 - 65℃; for 1.5h;	88%
With aluminum oxide; iodine; copper dichloride at 60℃; for 3h; also other polymethylbenzenes;	97 % Chromat.

: 95-63-6
1,2,4-Trimethylbenzene

: 528-44-9
1,2,4-benzene tricarboxylic acid

Conditions

Conditions	Yield
With air; acetic acid; 1N,3N,5N-trihydroxy-1,3,5-triazin-2,4,6[1H,3H,5H]-trione; cobalt(II) acetate; zirconyl acetate at 150℃; under 15200 Torr; for 6h;	97%
With 7H2O3H3N3H(1+)*[FeMo6O18(OH)6](3-); sodium carbonate; acetic acid at 100℃; under 750.075 Torr; for 12h; Reagent/catalyst; Temperature; Inert atmosphere;	97%
With cobalt(II) acetate; manganese(II) acetate; acetic acid at 110 - 220℃; under 14251.4 - 16501.7 Torr; Pressure; Temperature;	96.32%

: 773-64-8
2-mesitylenesulphonyl chloride

: 95-63-6
1,2,4-Trimethylbenzene

: 1417718-29-6
1,3,5-trimethyl-2-(2,4,5-trimethyl-benzenesulfonyl)-benzene

Conditions

Conditions	Yield
With aluminum (III) chloride In dichloromethane at 25℃; for 2h; Inert atmosphere;	96%
With aluminum (III) chloride In dichloromethane at 20℃; for 2h;	96%

: 95-63-6
1,2,4-Trimethylbenzene

: 5659-96-1
ethyl-methyl-malonyl dichloride

: 178387-33-2
2-ethyl-2,4,5,7-tetramethylindan-1,3-dione

Conditions

Conditions	Yield
AlCl3 In dichloromethane	93%

: 95-63-6
1,2,4-Trimethylbenzene

: 935-92-2
2,3,5-Trimethyl-1,4-benzoquinone

Conditions

Conditions	Yield
With phthalic anhydride; dihydrogen peroxide In neat (no solvent) at 118 - 120℃; for 2.5h; Reagent/catalyst; Temperature; Time; Solvent;	92%
With dihydrogen peroxide; acetic anhydride; methyltrioxorhenium(VII) In water at 60℃;	37%
With 3-chloro-benzenecarboperoxoic acid In chloroform at 60 - 70℃; for 0.5h;	16.5%

: 252913-37-4
[(η6-benzene)IrH2(P(iPr)3)]BF4

: 95-63-6
1,2,4-Trimethylbenzene

: 252913-45-4
[(η6-1,2,4-trimethylbenzene)IrH2(P(iPr)3)]BF4

Conditions

Conditions	Yield
In acetone under Ar; a soln. of Ir complex in acetone was treated with a 10-fold excess of the arene and stirred for 1 h; the soln. was concd., treated with a mixt. of (C2H5)2O/THF, the ppt. wasfiltered, washed with (C2H5)2O, dried in vac.; elem. anal.;	92%

: 95-63-6
1,2,4-Trimethylbenzene

: 31053-96-0
5-chloro-1,2,4-trimethylbenzene

Conditions

Conditions	Yield
With hydrogenchloride; sodium chloride; sodium hydroxide In water; acetonitrile Solvent; Reagent/catalyst;	91.2%
With benzyltrimethylazanium tetrachloro-λ3-iodanuide In acetic acid for 20h; Ambient temperature;	52%
With chlorine im Dunkeln;
With aluminium trichloride; sulfuryl dichloride

: 201230-82-2
carbon monoxide

: 95-63-6
1,2,4-Trimethylbenzene

A: 5779-72-6
2,4,5-trimethylbenzaldehyde

B: 3-Formyl-2,5,6-trimethylbenzenesulfonyl fluoride

Conditions

Conditions	Yield
With antimony pentafluoride; fluorosulphonic acid at 0℃; for 1h;	A 90% B 1%
With antimony pentafluoride; fluorosulphonic acid at 0℃; for 1h; Yields of byproduct given. Title compound not separated from byproducts;	A 90 % Chromat. B n/a

...Expand

: 3350-78-5
3,3-Dimethylacryloyl chloride

: 95-63-6
1,2,4-Trimethylbenzene

: 10425-85-1
2',3,4',5'-tetramethylcrotonophenone

Conditions

Conditions	Yield
With aluminium trichloride	89%
With aluminium trichloride In nitromethane

: 95-63-6
1,2,4-Trimethylbenzene

: 7377-26-6
4-Methoxycarbonylbenzoyl chloride

: 4-(2,4,5-trimethyl-benzoyl)-benzoic acid methyl ester

Conditions

Conditions	Yield
With In(OSO2CF3)3 for 0.133333h; Friedel-Crafts acylation reaction; microwave irradiation;	89%

: 95-63-6
1,2,4-Trimethylbenzene

A: 121-91-5
isophthalic acid

B: 100-21-0
terephthalic acid

C: 528-44-9
1,2,4-benzene tricarboxylic acid

Conditions

Conditions	Yield
With oxygen; titanium(IV) isopropylate; tetrabutoxytitanium; manganese(II) acetate; cobalt(II) acetate; ammonium bromide; cerous nitrate In water; acetic acid at 150 - 225℃; under 5250.53 - 18751.9 Torr; for 1.2 - 1.25h; Product distribution / selectivity;	A n/a B n/a C 88.3%

...Expand

: 7446-70-0
aluminium trichloride

: thallium chloride

: 95-63-6
1,2,4-Trimethylbenzene

: di-μ-tetrachloroaluminato-1κCl,1κCl':2κCl,2κCl''-bis(bis(η(6)-1,2,4-trimethylbenzene)thallium)

Conditions

Conditions	Yield
In further solvent(s) N2-atmosphere; equimolar amts. of TlCl and AlCl3, stirring in 1,2,4-trimethylbenzene at room temp.; filtration, slow cooling to 0°C (crystn.); elem. anal.;	86%

...Expand

: 95-63-6
1,2,4-Trimethylbenzene

: 2-bromo-5-(2-trimethylsilyloxy-1,1,1-trifluoroeth-2-yl)thiophene

: 2-(2,2,2-trifluoro-1-(2,4,5-trimethylphenyl)ethyl)thiophene

Conditions

Conditions	Yield
With trifluorormethanesulfonic acid In dichloromethane at -40℃; for 0.0166667h;	86%

: 95-63-6
1,2,4-Trimethylbenzene

: 700-13-0
Trimethylhydroquinone

Conditions

Conditions	Yield
Stage #1: 1,2,4-Trimethylbenzene With formic acid; dihydrogen peroxide; calcium chloride at 50 - 90℃; for 5h; Stage #2: With sodium dithionite In water at 45℃; for 2h; Temperature; Reagent/catalyst;	85.6%
With peracetic acid; sodium disulfite 1) acetic acid, 70 deg C, 1 h; 2) water, 20 deg C, 0.5 h.; Yield given. Multistep reaction;
Multi-step reaction with 3 steps 1: sodium bromide; sulfuric acid; iron(II) sulfate; iodine; dihydrogen peroxide / dichloromethane; water / 0 °C 2: potassium dichromate; sulfuric acid; copper(II) sulfate / water; acetonitrile / 45 °C 3: sodium carbonate; hydrogen / 80 °C View Scheme

: copper(II) hexafluoro-2,4-pentanedionate

: 872209-62-6
4,4,5,5-pentamethyl-2-(1'-n-butyl-pyrazole-4'-yl)-4,5-dihydro-1H-imidazolyl-3-oxide-1-oxyl

: 95-63-6
1,2,4-Trimethylbenzene

: Cu(hexafluoroacetylacetonate)2(2-(1-butyl-1H-pyrazol-4-yl)-4,4,5,5-tetramethyl-4,5-dihydro-1H-imidazole-3-oxide-1-oxyl)*1/2C9H12 Cu(CH(COCF3)2)2(C14H23N4O2)*0.5C9H12, high temperature

Conditions

Conditions	Yield
In further solvent(s) dissolving mixt. of copper compd. and nitronyl nitroxide deriv. in 1,2,4-trimethylbenzene with heating to 70°C for 2-3 min; cooling to room temp., keeping with slow evapn. at 5°C for 1-2 d,filtration, washing with cold heptane, air drying, elem. anal.;	85%

...Expand

: 95-63-6
1,2,4-Trimethylbenzene

: (E)-5-(4-chlorophenyl)-1-phenylpent-4-en-2-yn-1-one

: (E)-2-(3-(4-chlorophenyl)-4,5,7-trimethyl-2,3-dihydro-1H-inden-1-ylidene)-1-phenylethan-1-one

Conditions

Conditions	Yield
Stage #1: 1,2,4-Trimethylbenzene; (E)-5-(4-chlorophenyl)-1-phenylpent-4-en-2-yn-1-one With trifluorormethanesulfonic acid In dichloromethane at 20℃; Stage #2: With water In dichloromethane	85%

: 95-63-6
1,2,4-Trimethylbenzene

: 64-19-7
acetic acid

A: 935-92-2
2,3,5-Trimethyl-1,4-benzoquinone

B: 527-17-3, 70128-24-4
Duroquinone

C: 20469-61-8
2,3,5-trimethylanisole

D: 62687-45-0
2,3,6-trimethylphenyl acetate

E: 21573-38-6
1-methoxy-2,4,5-trimethylbenzene

F: 109576-73-0
3-acetoxy-2,5-dihydroxy-5-carboxy-2,3,5-trimethylpentan-4-olide

Conditions

Conditions	Yield
With peracetic acid at 70℃; for 0.5h; Product distribution; Kinetics; Thermodynamic data; other reaction time: 4 h.;	A 16% B 0.03% C 0.02% D 0.03% E 0.04% F 82.6%

...Expand

: 50-00-0
formaldehyd

: 95-63-6
1,2,4-Trimethylbenzene

: 55-21-0
benzamide

: C17H19NO

Conditions

Conditions	Yield
With water at 100℃; for 10h; Sealed tube; Green chemistry; regioselective reaction;	82%

...Expand

: 95-63-6
1,2,4-Trimethylbenzene

: C144H168O24

: C144H168O24*C9H12

Conditions

Conditions	Yield
at 160℃; for 72h; complexation;	81%

: 94363-96-9
[IrCl(C8H3(CH3)3C4F4)]2

: 95-63-6
1,2,4-Trimethylbenzene

: silver perchlorate

: 94364-06-4
[Ir(C8H3(CH3)3C4F4)(C6H3(CH3)3)](1+)*ClO4(1-)=[Ir(C8H3(CH3)3C4F4)(C6H3(CH3)3)]ClO4

Conditions

Conditions	Yield
In dichloromethane byproducts: AgCl; stirring, 1h; filtering off pptd. AgCl (kieselgur); concentrating; addn. of ether; pptn.; recrystn. (dichloromethane/ether); elem. anal.;	81%

...Expand

: 95-63-6
1,2,4-Trimethylbenzene

: 586-75-4
4-chlorobenzoyl chloride

: 1166846-04-3
4'-bromo-2,4,5-trimethylbenzophenone

Conditions

Conditions	Yield
Stage #1: 4-chlorobenzoyl chloride With aluminum (III) chloride In dichloromethane at -20℃; Friedel Crafts acylation; Inert atmosphere; Stage #2: 1,2,4-Trimethylbenzene In dichloromethane Friedel Crafts acylation; Stage #3: With hydrogenchloride; water In dichloromethane	81%

: 95-63-6
1,2,4-Trimethylbenzene

: 1260102-46-2
(E)-5-phenyl-1-(4-methylphenyl)pent-4-en-2-yn-1-one

: (E)-1-(4-methylphenyl)-2-(4,5,7-trimethyl-3-phenyl-2,3-dihydro-1H-inden-1-ylidene)ethan-1-one

Conditions

Conditions	Yield
Stage #1: 1,2,4-Trimethylbenzene; (E)-5-phenyl-1-(4-methylphenyl)pent-4-en-2-yn-1-one With trifluorormethanesulfonic acid In dichloromethane at 20℃; Stage #2: With water In dichloromethane	80%

1,2,4-TRIMETHYL BENZENE Chemical Properties

Product Name:1,2,4-Trimethylbenzene
Synonyms:1,3,4-TRIMETHYLBENZENE;1,2,4-TRIMETHYLBENZENE;PSI-CUMENE;PSEUDOCUMENE;PSEUDOCUMOL;PSC;TRIMETHYLBENZENE;1,2,4-trimethyl-benzen
Molecular formula:C₉H₁₂
Molecular Weight:120.19
EINECS: 202-436-9
Merck:14,7915
Melting point:-44 °C
Boiling point:168 °C(lit.)
refractive index:n20/D 1.504(lit.)
Fp:120 °F

1,2,4-TRIMETHYL BENZENE is stored at 2-8°C .Its density is 0.88,vapor density is 4.1 (vs air),and vapor pressure is 4.5 mm Hg ( 37.7 °C).

1,2,4-TRIMETHYL BENZENE Toxicity Data With Reference

1.	orl-rat LD50:5 g/kg	85JCAE Prehled Prumyslove Toxikologie; Organicke Latky Marhold, J.,Prague, Czechoslovakia.: Avicenum,1986,34.
2.	ihl-rat LC50:18 g/m3/4H	GISAAA Gigiena i Sanitariya. 44 (5)(1979),15.
3.	ipr-rat LDLo:1752 mg/kg	MEIEDD Merck Index. 10 (1983),1141.
4.	ipr-gpg LDLo:1788 mg/kg	AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. 9 (1954),227.

1,2,4-TRIMETHYL BENZENE Consensus Reports

Reported in EPA TSCA Inventory. Community Right-To-Know List.

1,2,4-TRIMETHYL BENZENE Safety Profile

Moderately toxic by intraperitoneal route. Mildly toxic by inhalation. Can cause central nervous system depression, anemia, bronchitis. Flammable liquid when exposed to heat, sparks, or flame. To fight fire, use foam, alcohol foam, mist. Emitted from modern building materials ( CENEAR Chemical and Engineering News. 69 (1991),22. ). When heated to decomposition it emits acrid smoke and irritating fumes.

1,2,4-TRIMETHYL BENZENE's Risk Statements:10-20-36/37/38-51/53-39/23/24/25-23/24/25-11
10:Flammable
11: Highly Flammable
20:Harmful by inhalation
36/37/38:Irritating to eyes, respiratory system and skin
51/53:Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment
39/23/24/25:Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed
23/24/25:Toxic by inhalation, in contact with skin and if swallowed

1,2,4-TRIMETHYL BENZENE's Safety Statements:26-61-45-36/37-16-7
26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
61:Avoid release to the environment. Refer to special instructions safety data sheet
45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
36/37:Wear suitable protective clothing and gloves
16:Keep away from sources of ignition - No smoking
7:Keep container tightly closed

Hazard Codes:Xn,N,F,Xi,T
RIDADR:UN 3295 3/PG 3
WGK Germany:2
RTECS:DC3325000
Hazard Note:Irritant/Flammable
HazardClass:3
PackingGroup:III

1,2,4-TRIMETHYL BENZENE Standards and Recommendations

OSHA PEL: TWA 25 ppm
ACGIH TLV: TWA 25 ppm
DFG MAK: 20 ppm

Product Name

1,2,4-Trimethylbenzene

Synthetic route

1,2,4-TRIMETHYL BENZENE Chemical Properties

1,2,4-TRIMETHYL BENZENE Toxicity Data With Reference

1,2,4-TRIMETHYL BENZENE Consensus Reports

1,2,4-TRIMETHYL BENZENE Safety Profile

1,2,4-TRIMETHYL BENZENE Standards and Recommendations

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