1,2-Dibromoethane supplier

Name
1,2-Dibromoethane
EINECS 203-444-5
CAS No. 106-93-4
Article Data109
CAS DataBase
Density 2.173 g/cm³
Solubility 4 g/L (20 °C) in water
Melting Point 9 °C
Formula C₂H₄Br₂
Boiling Point 130.2 °C at 760 mmHg
Molecular Weight 187.862
Flash Point 12.6 °C
Transport Information UN 1605 6.1/PG 1
Appearance Colorless to light yellow liquid
Safety 53-45-61-36/37/39-26-36/37-16-7
Risk Codes 45-23/24/25-36/37/38-51/53-34-39/23/24/25-11
Molecular Structure
Hazard Symbols T,N,F
Synonyms Soilfume;alpha,omega-dibromoethane;Iscobrome D;Soil-borne wheat mosaic virusSoilbrom;DBE;Aadibroom;EDB;Dowfume W 85;1,2-Dibromoethane(Ethylene bromide);Nefis;sym-Dibromoethane;ethylene bromide;alpha,beta-dibromoethane;Sanhyuum;1,2-dibromo- Ethane;1,2- Dibromoethane;Ethylene Dibromide;Ethane,1,2-dibromo-;Edabrom;
PSA 0.00000
LogP 1.77620

Synthetic route

: 74-84-0
ethane

: 106-93-4
ethylene dibromide

Conditions

Conditions	Yield
With 2AlBr3*CBr4; bromine at 55 - 65℃; for 18h;	100%
With 2AlBr3*CBr4; bromine at 55 - 65℃; for 18h; Product distribution; Mechanism; different times;	100%

: 74-85-1
ethene

: 106-93-4
ethylene dibromide

Conditions

Conditions	Yield
With bromine; iodobis(N,N-diisopropyldithiocarbamato)iron(III) In dichloromethane at 20℃; under 760 Torr;	98%
With bromine at -5℃;	91%
With bromine

: 74-85-1
ethene

: 81373-35-5
di(neopentyloxy)thioxophosphoranesulphenyl bromide

A: 74895-06-0
bis-(O,O-2,2-dimethylpropylthiophosphoryl)disulfide

B: 106-93-4
ethylene dibromide

C: Dithiophosphoric acid S-(2-bromo-ethyl) ester O,O'-bis-(2,2-dimethyl-propyl) ester

Conditions

Conditions	Yield
In toluene at 0 - 15℃;	A 97% B n/a C 3%

...Expand

: 107-21-1
ethylene glycol

: 106-93-4
ethylene dibromide

Conditions

Conditions	Yield
With 1,2-dibromo-1,1,2,2-tetrachloroethane; triphenylphosphine In dichloromethane at 20℃; for 0.15h; Appel Halogenation;	96%
With phosphorus; phosphorous; bromine
With sulfuric acid; hydrogen bromide
bromination;
With tetrabutylammomium bromide; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone In dichloromethane at 20℃;	78 % Chromat.

: 105089-47-2
N-bromo-1,8-naphthalenedicarboximide

: 71-43-2
benzene

A: 6914-98-3
2-phenylbenzo[de]isoquinoline-1,3-dione

B: 106-93-4
ethylene dibromide

Conditions

Conditions	Yield
With ethene In dichloromethane at 70℃; Irradiation;	A 79% B 89%

...Expand

: 6351-10-6
1-Indanol

A: 83-33-0
inden-1-one

B: 106-93-4
ethylene dibromide

Conditions

Conditions	Yield
With air; bromine; sodium carbonate; adogen 464; palladium dichloride Product distribution; multistep reaction: 1.) 1,2-dichloroethane, reflux, 15 h, 2.) CCl4; reactions under var. conditions, reactions of derivatives;	A 88% B n/a

: 67-56-1
methanol

Tetracarbonyleisenkomplexe des Ethylens: Tetracarbonyleisenkomplexe des Ethylens

A: 3395-91-3
Methyl 3-bromopropionate

B: 3852-09-3
methyl 3-methoxypropionate

C: 106-93-4
ethylene dibromide

D: 6482-24-2
2-Bromoethyl methyl ether

Conditions

Conditions	Yield
With bromine at -80℃; temperature up to 30 deg C;	A 67% B n/a C n/a D n/a

...Expand

: 107-06-2
1,2-dichloro-ethane

A: 107-04-0
1-Bromo-2-chloroethane

B: 106-93-4
ethylene dibromide

Conditions

Conditions	Yield
With calcium bromide; tetrahexylammonium bromide at 110℃; for 24h;	A 38% B 53%

: 107-21-1
ethylene glycol

A: 106-93-4
ethylene dibromide

B: 540-51-2
2-bromoethanol

Conditions

Conditions	Yield
With 1,2-dibromo-1,1,2,2-tetrachloroethane; triphenylphosphine In dichloromethane at 20℃; for 0.15h; Appel Halogenation;	A 50% B 45%

: 74-85-1
ethene

: 7182-86-7
tetrabutylammonium p-toluenesulfonate

A: 19263-21-9
2-bromoethyl p-toluenesulfonate

B: 106-93-4
ethylene dibromide

Conditions

Conditions	Yield
With bromine In dichloromethane at 20℃; Product distribution; Mechanism;	A 34% B 51 % Spectr.
With bromine In dichloromethane at 20℃;	A 34% B 51 % Spectr.
With bromine In dichloromethane Ambient temperature;

...Expand

: 74-85-1
ethene

A: 19263-21-9
2-bromoethyl p-toluenesulfonate

B: 106-93-4
ethylene dibromide

Conditions

Conditions	Yield
With bromine; tetrabutylammonium p-toluenesulfonate In dichloromethane at 20℃;	A 34% B 51 % Spectr.

: 74-85-1
ethene

A: 106-93-4
ethylene dibromide

B: Dithiophosphoric acid S-(2-bromo-ethyl) ester O,O'-bis-(2,2-dimethyl-propyl) ester

Conditions

Conditions	Yield
With (tBuCH2O)2P(S)SBr In toluene at 0 - 15℃;	A n/a B 3%

: 74-96-4
ethyl bromide

: 106-93-4
ethylene dibromide

Conditions

Conditions	Yield
With aluminum tri-bromide; bromine at 65 - 70℃;
With bromine at 180℃;
With bromine; iron at 100℃;

: 593-60-2
Vinyl bromide

: 106-93-4
ethylene dibromide

Conditions

Conditions	Yield
With hydrogen bromide
With hydrogen bromide at 100 - 200℃;
With hydrogen bromide

: 593-60-2
Vinyl bromide

A: 557-91-5
1,1-Dibromoethane

B: 106-93-4
ethylene dibromide

Conditions

Conditions	Yield
With magnesium hydrosilicate; hydrogen bromide

: 557-91-5
1,1-Dibromoethane

: 106-93-4
ethylene dibromide

Conditions

Conditions	Yield
at 300 - 320℃;
at 300 - 315℃;

: 506-96-7
Acetyl bromide

: 622-22-0
1,2-dibenzyloxyethane

A: 140-11-4
Benzyl acetate

B: 106-93-4
ethylene dibromide

...Expand

: 74-85-1
ethene

: 934-55-4
potassium benzenesulfonate

A: 61855-70-7
benzenesulfonic acid-(2-bromo-ethyl ester)

B: 106-93-4
ethylene dibromide

Conditions

Conditions	Yield
With water; bromine

...Expand

: 75-00-3
chloroethane

: 106-93-4
ethylene dibromide

Conditions

Conditions	Yield
With water; bromine; iron at 100℃;

: 506-96-7
Acetyl bromide

: 589-10-6
phenoxyethyl bromide

A: 106-93-4
ethylene dibromide

B: 122-79-2
Phenyl acetate

...Expand

: 107-06-2
1,2-dichloro-ethane

: 106-93-4
ethylene dibromide

Conditions

Conditions	Yield
With aluminum tri-bromide unterhalb des Siedepunkts;
With aluminum tri-bromide

: 107-04-0
1-Bromo-2-chloroethane

: 106-93-4
ethylene dibromide

Conditions

Conditions	Yield
With aluminum tri-bromide unterhalb des Siedepunkts;

: 74-86-2
acetylene

: 106-93-4
ethylene dibromide

Conditions

Conditions	Yield
With hydrogen bromide; pyrographite at 220℃;
With metal bromide-contact; hydrogen bromide at 100 - 200℃;
With air; hydrogen bromide; chlorine

: dioxane*BBr3=Dioxan*BBr3

A: 2-Bromaethyl-metaborat

B: 106-93-4
ethylene dibromide

Conditions

Conditions	Yield
at 30℃;

: 111-87-5
octanol

A: 111-83-1
1-bromo-octane

B: 106-93-4
ethylene dibromide

Conditions

Conditions	Yield
With Bis-(2-bromoethyl)selenium dibromide at 80℃; for 7h; Product distribution; Mechanism; other dialkylselenium dihalides; other alcohols;	A 98 % Chromat. B 75 % Chromat.

: 74-85-1
ethene

: 75-09-2
dichloromethane

: 594-11-6
methylcyclopropane

: 82621-80-5
2,2-dimethyl-N-bromoglutarimide

A: 5162-44-7
1-bromo-4-butene

B: 1194-33-8
2,2-dimethylglutarimide

C: 75-27-4
bromodichloromethane

D: N-(2-bromoethyl)-3,3-dimethylglutarimide

E: 106-93-4
ethylene dibromide

F: 7051-34-5
cyclopropylcarbinyl bromide

Conditions

Conditions	Yield
at 15℃; for 1h; Product distribution; Kinetics; Mechanism; Irradiation;	A 1.7 % Chromat. B 50.4 % Chromat. C 12.8 % Chromat. D 50.1 % Chromat. E 2.0 % Chromat. F 18.0 % Chromat.

...Expand

: 74-85-1
ethene

: 65411-49-6
tetrabutylammonium methanesulfonate

A: 4239-10-5
2-bromoethyl methanesulfonate

B: 106-93-4
ethylene dibromide

Conditions

Conditions	Yield
With bromine In dichloromethane Ambient temperature;

...Expand

: 74-85-1
ethene

: 35895-70-6
tetrabutylammonium trifluoromethylsulfonate

A: 103935-47-3
2-bromoethyl triflate

B: 106-93-4
ethylene dibromide

Conditions

Conditions	Yield
With bromine at -78 - 20℃; various solvents; Yield given. Yields of byproduct given;

...Expand

: 74-85-1
ethene

: 33454-82-9
lithium trifluoromethanesulfonate

A: 103935-47-3
2-bromoethyl triflate

B: 106-93-4
ethylene dibromide

Conditions

Conditions	Yield
With bromine at -78 - 20℃; various solvents; Yield given. Yields of byproduct given;

...Expand

: 124-40-3
dimethyl amine

: 106-93-4
ethylene dibromide

: 110-18-9
N,N,N,N,-tetramethylethylenediamine

Conditions

Conditions	Yield
In tetrahydrofuran at 0 - 20℃; for 24h;	100%
In chloroform at 20℃; for 24h;	100%

: 52-90-4
L-Cysteine

: 106-93-4
ethylene dibromide

: 14344-49-1
S,S'-ethanediyl-bis-L-cysteine

Conditions

Conditions	Yield
With sodium hydrogencarbonate In ethanol; water at 70 - 90℃; for 1h;	100%
With sodium hydrogencarbonate	88%

: 95-56-7
2-hydroxybromobenzene

: 106-93-4
ethylene dibromide

: 18800-28-7
1-(2-bromoethoxy)-2-bromobenzene

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile at 80℃;	100%
With caesium carbonate In acetonitrile at 80℃; for 11h; Inert atmosphere; Schlenk technique;	88%
With sodium hydroxide for 6.5h; Etherification; Heating;	72%

: 75-15-0
carbon disulfide

: 106-93-4
ethylene dibromide

: 123-54-6
acetylacetone

: 2183-30-4
3-(1,3-dithiolan-2-ylidene)pentane-2,4-dione

Conditions

Conditions	Yield
With potassium carbonate	100%
Stage #1: carbon disulfide; acetylacetone With tetrabutylammomium bromide; potassium carbonate In water at 20℃; Stage #2: ethylene dibromide In water at 20℃; for 8h;	97%
Stage #1: carbon disulfide; acetylacetone With tetrabutylammomium bromide; potassium carbonate In water at 20℃; for 1h; Stage #2: ethylene dibromide In water at 20℃; for 8.25h; Further stages.;	97%

...Expand

: 106-93-4
ethylene dibromide

: 75-08-1
ethanethiol

: 5244-34-8
2,2'-ethane-1,2-diylbissulfanyl-bis-ethanol

Conditions

Conditions	Yield
With sodium ethanolate In ethanol for 1h; Heating;	100%

: 106-93-4
ethylene dibromide

: 205366-80-9
(1R,2R)-1-(4-Methoxy-phenyl)-2-(3,4,5-trimethoxy-phenyl)-ethane-1,2-diol

: (2R,3R)-2-(4-Methoxy-phenyl)-3-(3,4,5-trimethoxy-phenyl)-[1,4]dioxane

Conditions

Conditions	Yield
With sodium hydroxide; cetyltrimethylammonium chloride	100%

: 141-52-6
sodium ethanolate

: 106-93-4
ethylene dibromide

: 106-45-6
para-thiocresol

: 57023-03-7
(2-ethoxyethyl)-para-thiocresol

Conditions

Conditions	Yield
Stage #1: para-thiocresol With sodium ethanolate In ethanol at 20℃; Metallation; Stage #2: ethylene dibromide In ethanol at 20℃; Alkylation; Stage #3: sodium ethanolate In ethanol Substitution; Heating;	100%

...Expand

: 1202-34-2
di(pyridin-2-yl)amine

: 106-93-4
ethylene dibromide

: 1-(pyridin-2-yl)-2,3-dihydro-1H-imidazo[1,2-a]pyridinium bromide

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine for 18h; Heating;	100%

: 106-93-4
ethylene dibromide

: tert-butyl 4-hydroxy-5-methoxy-11-azatricyclo[6.2.1.02,7]undeca-2(7),3,5-triene-11-carboxylate

: tert-butyl 4-(2-bromoethoxy)-5-methoxy-11-azatricyclo[6.2.1.02,7]undeca-2(7),3,5-triene-11-carboxylate

Conditions

Conditions	Yield
With potassium hydroxide; tetra(n-butyl)ammonium hydroxide In water at 50℃; for 15h;	100%

: 106-93-4
ethylene dibromide

: tert-butyl 4-hydroxy-5-[(naphthalen-1-yl)methoxy]-11-azatricyclo[6.2.1.02,7]undeca-2(7),3,5-triene-11-carboxylate

: tert-butyl 4-(2-bromoethoxy)-5-[(naphthalen-1-yl)methoxy]-11-azatricyclo[6.2.1.02,7]undeca-2(7),3,5-triene-11-carboxylate

Conditions

Conditions	Yield
With potassium hydroxide; tetra(n-butyl)ammonium hydroxide In water at 50℃; for 15h;	100%

: 106-93-4
ethylene dibromide

: tert-butyl 4-hydroxy-5-[(naphthalen-2-yl)methoxy]-11-azatricyclo[6.2.1.02,7]undeca-2(7),3,5-triene-11-carboxylate

: tert-butyl 4-(2-bromoethoxy)-5-[(naphthalen-2-yl)methoxy]-11-azatricyclo[6.2.1.02,7]undeca-2(7),3,5-triene-11-carboxylate

Conditions

Conditions	Yield
With potassium hydroxide; tetra(n-butyl)ammonium hydroxide In water at 50℃; for 15h;	100%

: 626-02-8
3-Iodophenol

: 106-93-4
ethylene dibromide

: 626250-32-6
1-(2-bromoethoxy)-3-iodobenzene

Conditions

Conditions	Yield
With potassium carbonate In acetone for 48h; Heating;	100%
With potassium carbonate In acetone at 55℃;	92%
With potassium carbonate In acetone at 0 - 55℃; Inert atmosphere;	85%
With potassium carbonate; potassium iodide In acetone at 60℃;	69%
Stage #1: 3-Iodophenol With potassium carbonate In N,N-dimethyl-formamide for 0.5h; Inert atmosphere; Stage #2: ethylene dibromide In N,N-dimethyl-formamide at 20 - 55℃; Inert atmosphere;	38%

: 55403-02-6
1,2-bis(4,5-dihydro-1H-imidazol-1-yl)ethane

: 106-93-4
ethylene dibromide

: 2,3,4,5,6,7,8,8c-octahydro-1H-4a,6a,8a-triaza-2a-azoniacyclopent[fg]acenaphthylene bromide salt

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile for 3h; Heating;	100%
With potassium carbonate In acetonitrile for 3h; Heating;	70%

: 1017961-91-9
5-acetyl-7-(3-(4-fluorophenyl)butoxy)-6-hydroxy-4-methylbenzofuran

: 106-93-4
ethylene dibromide

: 5-acetyl-6-(2-bromoethoxy)-7-(3-(4-fluorophenyl)butoxy)-4-methylbenzofuran

Conditions

Conditions	Yield
With caesium carbonate In N,N-dimethyl-formamide at 60℃; for 1.5h;	100%

: 15231-91-1
6-bromo-naphthalen-2-ol

: 106-93-4
ethylene dibromide

: 205112-20-5
2-bromo-6-(2-bromoethoxy)naphthalene

Conditions

Conditions	Yield
With potassium hydroxide; tetrabutylammomium bromide In water at 100℃; for 3h;	100%
With potassium carbonate In acetonitrile at 95℃; for 8h;	50%
With potassium carbonate In acetonitrile at 95℃; for 8h;	50%
With potassium carbonate In N,N-dimethyl-formamide at 20℃; Inert atmosphere;	37.54%

: 404866-70-2
C54H44N2S2

: 106-93-4
ethylene dibromide

: C56H46N2S2

Conditions

Conditions	Yield
With sodium hydroxide; tetrabutylammomium bromide In water for 0.25h;	100%

: 654-01-3
(2,6-difluorophenyl)acetonitrile

: 106-93-4
ethylene dibromide

: 124276-65-9
1-(2,6-difluorophenyl)cyclopropane-1-carbonitrile

Conditions

Conditions	Yield
With sodium hydroxide; tetrabutylammomium bromide In water Product distribution / selectivity;	100%
With sodium hydroxide	52%
With sodium hydroxide; tetrabutylammomium bromide In water at 35 - 47℃; for 3.5h;
With N-benzyl-N,N,N-triethylammonium chloride; potassium hydroxide In water at 60 - 65℃; for 6h;

: ammonium hexafluorophosphate

: 75-52-5
nitromethane

: 823807-71-2
[(η6-C6Me6)Ru(η3-NH(CH2CH2S)2)]

: 106-93-4
ethylene dibromide

: [(η6-C6Me6)Ru(η3-S(CH2)2NH(CH2)2S(CH2)2)](PF6)2*MeNO2

Conditions

Conditions	Yield
In methanol to soln. Ru complex in MeOH Br(CH2)2Br was added and stirred for 2 h, NH4PF6 was added and stirred for 1 h; react. mixt. was evacuated to dryness, residue was extd. with MeCN, filtered through Celite, evacuated to dryness, residue was dissolved in MeNO2, layered with ether andkept at -30°C for 3 days; elem. anal.;	100%

...Expand

: C5(CH3)5Ru(C5H4CH2C4H7NCH2OCH3)

: 106-93-4
ethylene dibromide

: (Sp)-Cp*Ru[1-Br-2-(CH2NC4H7CH2OCH3)C5H3]

Conditions

Conditions	Yield
With LisBu In diethyl ether; cyclohexane (inert atm.); Ru complex in Et2O cooled to -78°C, treated with LisBu in cyclohexane (1:1.70) at -78°C within 20-30 s, stirred at -78°C for 3.5 h, treated with suspn. of ligand in Et2O, warmed to room temp. within 2.5 h, stirred for; evapd.(vac.), extd.(pentane), filtered (kieselghur), freed of volatiles,elem. anal.;	100%

: 918524-63-7
1-methyl-4-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)piperazine

: 106-93-4
ethylene dibromide

: 1168722-41-5
1-methyl-4-(5-vinylpyridin-2-yl)piperazine

Conditions

Conditions	Yield
Stage #1: ethylene dibromide With potassium hydroxide In tetrahydrofuran at 95℃; for 1.16667h; Inert atmosphere; Microwave irradiation; Stage #2: 1-methyl-4-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)piperazine With triphenylphosphine; palladium diacetate In tetrahydrofuran; methanol at 95℃; for 1h; Microwave irradiation;	100%
Stage #1: ethylene dibromide With potassium hydroxide In tetrahydrofuran at 95℃; for 1.16667h; Microwave irradiation; Inert atmosphere; Stage #2: 1-methyl-4-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)piperazine With palladium diacetate; triphenylphosphine In tetrahydrofuran at 95℃; for 1h; Microwave irradiation; Inert atmosphere;	93%

: 59443-15-1
5-chloro-3-bromo-2-hydroxyacetophenone

: 106-93-4
ethylene dibromide

: 1210038-73-5
3'-bromo-2'-(2-bromoethoxy)-5'-chloroacetophenone

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 50℃;	100%

: 81903-37-9
1,1,2,5,6,6-hexamethyl-1,6-dihydronaphtho<2,1-b:3,4-b'>dipyrrole

: 106-93-4
ethylene dibromide

: 2Br(1-)*C22H26N2(2+)

Conditions

Conditions	Yield
at 160℃; for 8h; sealed tube;	100%

: 106-93-4
ethylene dibromide

: 181585-93-3
5-nitro-2H-pyrazole-3-carboxylic acid methyl ester

: 1360057-00-6
methyl 1-(2-bromoethyl)-3-nitro-1H-pyrazole-5-carboxylate

Conditions

Conditions	Yield
With caesium carbonate In N,N-dimethyl-formamide at 0 - 100℃; for 4h;	100%
Stage #1: 5-nitro-2H-pyrazole-3-carboxylic acid methyl ester With caesium carbonate In N,N-dimethyl-formamide at 98℃; for 0.0833333h; Stage #2: ethylene dibromide at 0 - 20℃; for 5h;	92%
With potassium carbonate In acetone for 2h; Reflux;	77%
With potassium carbonate In acetone for 2h; Product distribution / selectivity; Reflux;	63%
With potassium carbonate In acetone at 60℃; for 1h;	41.1 mmol

: ethyl methyl 2-(3-methylisoxazol-5-yl)acetate

: 106-93-4
ethylene dibromide

: 1380090-06-1
ethyl 1-(3-methylisoxazol-5-yl)cyclopropanecarboxylate

Conditions

Conditions	Yield
With sodium hydroxide; tetrabutyl ammonium fluoride In toluene at 20℃; for 1h;	100%

: 106-93-4
ethylene dibromide

: 2338-76-3
3-trifluoromethylphenylacetonitrile

: 1-(3-(trifluoromethyl)phenyl)cyclopropane-1-carbonitrile

Conditions

Conditions	Yield
Stage #1: 3-trifluoromethylphenylacetonitrile With sodium hydride In N,N-dimethyl-formamide at 0℃; for 0.166667h; Stage #2: ethylene dibromide In N,N-dimethyl-formamide at 20℃; for 3h;	100%

: 53-16-7
Estrone

: 106-93-4
ethylene dibromide

: 191155-58-5
3-(2’-bromoethoxy)estra-1,3,5(10)-trien-17-one

Conditions

Conditions	Yield
With sodium hydroxide In tetrahydrofuran; water Reflux;	100%
With sodium hydroxide In tetrahydrofuran; water Reflux;	84%

: 60-29-7
diethyl ether

: 106-93-4
ethylene dibromide

: 29858-07-9
magnesium bromide diethyl etherate

Conditions

Conditions	Yield
With magnesium Heating;	100%

: 59939-75-2
(1,4-diazepan-1-yl)(phenyl)methanone

: 106-93-4
ethylene dibromide

: 1,1'-ethane-1,2-diylbis(4-benzoyl-1,4-diazepane)

Conditions

Conditions	Yield
With sodium hydrogencarbonate In ethanol for 16h; Heating;	100%

: 106-93-4
ethylene dibromide

: 1002-40-0
bis-(2-bromoethyl) disulfide

Conditions

Conditions	Yield
With sodium hydrogensulfide; oxygen In ethanol; water at 76℃; for 8h; Temperature; Reflux;	100%

1,2-Dibromoethane Consensus Reports

NTP 10th Report on Carcinogens. IARC Cancer Review: Group 2A IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 , 1987,p. 204.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 15 , 1977,p. 195.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . NCI Carcinogenesis Bioassay (gavage); Clear Evidence: mouse, rat NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD 20014) No. NCI-CG-TR-86 ,1978. ; NTP Carcinogenesis Bioassay (inhalation); Clear Evidence: mouse, rat NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No. NTP-TR-210 ,1982. . EPA Genetic Toxicology Program. Community Right-To-Know List. Reported in EPA TSCA Inventory.

1,2-Dibromoethane Standards and Recommendations

OSHA PEL: TWA 20 ppm; CL 30 ppm; Pk 50 ppm/5M/8H
ACGIH TLV: Animal Carcinogen
DFG MAK: DFG TRK: Animal Carcinogen, Suspected Human Carcinogen
NIOSH REL: (EDB) 0.045 ppm; CL 1 mg/m³/15M
DOT Classification: 6.1; Label: Poison

1,2-Dibromoethane Analytical Methods

For occupational chemical analysis use OSHA: #02 or NIOSH: Ethylene Dibromide, 1008.

1,2-Dibromoethane Specification

The IUPAC name of 1,2-Dibromoethane is 1,2-dibromoethane. With the CAS registry number 106-93-4, it is also named as Aadibroom; Celmide. The product's categories are organics and bromine chemicals. It is colorless to light yellow liquid with a sweetish odor. And it is slightly soluble in water, and soluble in most organic solvents and thinners. In addition, this chemical slowly decomposes in the presence of light and heat, so it may turn brown upon exposure to light. It is corrosive to iron and other metals and may decompose upon contact with alkalis. Furthermore, it is incompatible with oxidizing agents. Reacts with sodium, potassium, calcium, powdered aluminum, zinc, magnesium and liquid ammonia.

The other characteristics of 1,2-Dibromoethanecan be summarized as:
(1)ACD/LogP: 2.08; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 2.08; (4)ACD/LogD (pH 7.4): 2.08; (5)ACD/BCF (pH 5.5): 22.42; (6)ACD/BCF (pH 7.4): 22.42; (7)ACD/KOC (pH 5.5): 322.43; (8)ACD/KOC (pH 7.4): 322.43; (9)#H bond acceptors: 0; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 1; (12)Index of Refraction: 1.521; (13)Molar Refractivity: 26.77 cm³; (14)Molar Volume: 87.9 cm³; (15)Polarizability: 10.61×10^-24 cm³; (16)Surface Tension: 36.4 dyne/cm; (17)Enthalpy of Vaporization: 34.77 kJ/mol; (18)Vapour Pressure: 12 mmHg at 25°C; (19)Rotatable Bond Count: 1; (20)Exact Mass: 187.865929; (21)MonoIsotopic Mass: 185.867975; (22)Heavy Atom Count: 4.

Preparation of 1,2-Dibromoethane:
It can be obtained by ethene petroleum ether and bromine under Geschwindigkeit der Reaktion at -80 - -100°C.

Uses of 1,2-Dibromoethane:
It can be used as ethyl reagents and solvents.In agriculture, it is used as a nematicide and synthetic plant growth regulator. And it is also used as intermediate in synthesis of diethyl-bromophenyl acetonitrile, and fire retardant of vinyl bromide in medicine. In addition, it is used in gasoline to eliminate lead in seismic liquid agent, metal surface treatment agent and fire-fighting agent. It reacts with 2,4,5-tribromo-1H-imidazole to get 2,4,5-tribromo-1-vinylimidazole. This reaction needs reagent aq. tetrabutylammonium bromide and aq. NaOH by heating. The reaction time is 3 hours. The yield is 90 %.

Safety informationg of 1,2-Dibromoethane:
When you are using this chemical, please be cautious about it as the following:It is highly flammable, so it is toxic by inhalation, in contact with skin and if swallowed. And it is irritating to eyes, respiratory system and skin. In addition, this chemical may cause cancer and is toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. If you want to contact this product, you must wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)

People can use the following data to convert to the molecule structure.
(1)SMILES:BrCCBr;
(2)Std. InChI:InChI=1S/C2H4Br2/c3-1-2-4/h1-2H2;
(3)Std. InChIKey:PAAZPARNPHGIKF-UHFFFAOYSA-N.

The following are the toxicity data of 1,2-Dibromoethane:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
chicken	LD50	oral	79mg/kg (79mg/kg)		AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 6, Pg. 158, 1952.
guinea pig	LCLo	inhalation	400ppm/3H (400ppm)		AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 6, Pg. 158, 1952.
guinea pig	LCLo	inhalation	400ppm/3H (400ppm)	LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), ZONAL"	AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 6, Pg. 158, 1952.
guinea pig	LD50	oral	110mg/kg (110mg/kg)		AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 6, Pg. 158, 1952.
man	TDLo	oral	43uL/kg (0.043mL/kg)	LIVER: "JAUNDICE, OTHER OR UNCLASSIFIED" KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"	Human & Experimental Toxicology. Vol. 19, Pg. 152, 2000.
mouse	LD50	intraperitoneal	220mg/kg (220mg/kg)		Journal fuer Praktische Chemie. Vol. 320, Pg. 133, 1978.
mouse	LD50	unreported	146mg/kg (146mg/kg)		"Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971Vol. -, Pg. 38, 1971.
mouse	LDLo	oral	250mg/kg (250mg/kg)		Toxicology and Applied Pharmacology. Vol. 23, Pg. 288, 1972.
quail	LD50	oral	130mg/kg (130mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	British Poultry Science. Vol. 22, Pg. 355, 1981.
rabbit	LD50	oral	55mg/kg (55mg/kg)		AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 6, Pg. 158, 1952.
rabbit	LD50	skin	300mg/kg (300mg/kg)		AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 6, Pg. 158, 1952.
rabbit	LD50	skin	300mg/kg (300mg/kg)	SKIN AND APPENDAGES (SKIN): CORROSIVE: AFTER TOPICAL EXPOSURE	AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 6, Pg. 158, 1952.
rabbit	LDLo	rectal	2500mg/kg (2500mg/kg)	LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE"	Journal of Pharmacology and Experimental Therapeutics. Vol. 34, Pg. 223, 1928.
rat	LC50	inhalation	14300mg/m³/30 (14300mg/m³)	PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Farmakologiya i Toksikologiya Vol. 8, Pg. 140, 1973.
rat	LD50	oral	108mg/kg (108mg/kg)		Special Publication of the Entomological Society of America. Vol. 78-1, Pg. 17, 1978.
rat	LD50	skin	300mg/kg (300mg/kg)		"Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel," Perkow, W., Berlin, Verlag Paul Parey, 1971-1976Vol. -, Pg. -, 1971/1976.
women	LDLo	oral	90mg/kg (90mg/kg)	GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" GASTROINTESTINAL: NAUSEA OR VOMITING KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED	"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 257, 1969.

Product Name

1,2-Dibromoethane

Synthetic route

1,2-Dibromoethane Consensus Reports

1,2-Dibromoethane Standards and Recommendations

1,2-Dibromoethane Analytical Methods

1,2-Dibromoethane Specification

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