1,4-Difluorobenzene supplier

Name
1,4-Difluorobenzene
EINECS 208-742-9
CAS No. 540-36-3
Article Data99
CAS DataBase
Density 1.165 g/cm³
Solubility
Melting Point -13 °C
Formula C₆H₄F₂
Boiling Point 90.4 °C at 760 mmHg
Molecular Weight 114.095
Flash Point 2.1 °C
Transport Information UN 1993 3/PG 2
Appearance Clear colorless to light yellow liquid
Safety 16-29-33-7-45-36/37-7/9
Risk Codes 11-20-39/23/24/25-23/24/25
Molecular Structure
Hazard Symbols F, Xn, T
Synonyms Benzene,p-difluoro- (6CI,8CI);2,5-Difluorobenzene;NSC 10286;p-Difluorobenzene;
PSA 0.00000
LogP 1.96480

Synthetic route

: 455-17-4
(p-fluorophenyl)trimethylsilane

A: 420-56-4
trimethylsilyl fluoride

B: 540-36-3
para-difluorobenzene

Conditions

Conditions	Yield
With xenon fluoride In dichloromethane Inert atmosphere;	A n/a B 100%

: 1516885-12-3
C6H4FN2(1+)*C6BF8(1-)

: sodium fluoride

A: 13755-29-8
sodium tetrafluoroborate

B: 540-36-3
para-difluorobenzene

C: C6BF14(1-)*Na(1+)

D: C6BF14(1-)*Na(1+)

Conditions

Conditions	Yield
at 160 - 170℃; Glovebox;	A 5% B 95% C 83% D 10%

...Expand

: 100-25-4
para-dinitrobenzene

: 540-36-3
para-difluorobenzene

Conditions

Conditions	Yield
With tetrabutyl ammonium fluoride In tetrahydrofuran for 0.166667h; Inert atmosphere; Microwave irradiation;	93%

: C6H4FN2(1+)*C8BF18(1-)

A: 540-36-3
para-difluorobenzene

B: 1516885-18-9
C8HF15

C: 85794-30-5
C8F14

D: C8BF17

Conditions

Conditions	Yield
at 90 - 95℃;	A 90% B 4% C 3% D 5%

...Expand

: 459-45-0
4-fluorobenzenediazonium tetrafluoroborate

: 540-36-3
para-difluorobenzene

Conditions

Conditions	Yield
at 158 - 160℃;	86%

: 1765-93-1
4-fluoroboronic acid

: 540-36-3
para-difluorobenzene

Conditions

Conditions	Yield
Stage #1: 4-fluoroboronic acid With sodium hydroxide In methanol at 23℃; for 0.25h; Inert atmosphere; Stage #2: With silver trifluoromethanesulfonate In methanol at 0℃; for 0.5h; Inert atmosphere; Stage #3: With Selectfluor In acetone at 23℃; for 1h; Inert atmosphere; Molecular sieve; regiospecific reaction;	85%
Multi-step reaction with 2 steps 1: diethyl ether / 20 °C / Inert atmosphere; Molecular sieve 2: silver fluoride; (tBuCN)2Cu*OTf; 1-fluoro-2,4,6-trimethylpyridinium hexafluorophosphate / tetrahydrofuran / 18 h / 50 °C / Inert atmosphere View Scheme
With potassium fluoride; copper(II) bis(trifluoromethanesulfonate) In acetonitrile at 60℃; for 20h; Sealed tube;
Multi-step reaction with 2 steps 1: potassium fluoride / acetonitrile / 16 h / 90 °C 2: 2,6-dichloro-1-fluoropyridin-1-ium tetrafluoroborate / chloroform / 6 h / 110 °C View Scheme

: 1516885-15-6
C6H4FN2(1+)*C6BF16(1-)

A: 329009-01-0
perfluorohexyldifluoroborane

B: 540-36-3
para-difluorobenzene

Conditions

Conditions	Yield
at 110 - 115℃;	A 85% B 67%

: 1516885-16-7
C6H4FN2(1+)*C12BF28(1-)

A: 540-36-3
para-difluorobenzene

B: 1516885-19-0
C12BF27

Conditions

Conditions	Yield
at 140 - 145℃;	A 79% B 85%

: 106-50-3
1,4-phenylenediamine

: 540-36-3
para-difluorobenzene

Conditions

Conditions	Yield
With hydrogenchloride; tetrafluoroboric acid; sodium nitrite In water at 50℃; for 0.0166667h; Temperature; Large scale;	83%
With pyridine hydrogenfluoride; sodium nitrite 1.) O deg C, 20 min, 2.) 120 deg C, 1 h;	65%
With pyridine; hydrogen fluoride; sodium nitrite 1.) room temperature, 2.) 0 deg C, 3.) 120 deg C; Yield given. Multistep reaction;

: 1516885-16-7
C6H4FN2(1+)*C12BF28(1-)

: sodium fluoride

A: 13755-29-8
sodium tetrafluoroborate

B: 540-36-3
para-difluorobenzene

C: 1516885-26-9
C12BF28(1-)*Na(1+)

D: 1516885-25-8
C12BF28(1-)*Na(1+)

Conditions

Conditions	Yield
at 25 - 200℃; for 0.133333h; Glovebox;	A 17% B 81% C 39% D 33%

...Expand

: C6H4FN2(1+)*C6BF14(1-)

A: 540-36-3
para-difluorobenzene

B: 375856-42-1
perfluoro-trans-hex-1-enyldifluoroborane

Conditions

Conditions	Yield
at 80 - 90℃;	A 80% B 49%

: 1516885-12-3
C6H4FN2(1+)*C6BF8(1-)

: sodium fluoride

A: 13755-29-8
sodium tetrafluoroborate

B: 540-36-3
para-difluorobenzene

C: 1516885-20-3
C6BF8(1-)*Na(1+)

Conditions

Conditions	Yield
at 160 - 170℃; Glovebox;	A 11% B 79% C 71%

...Expand

: 371-41-5
4-Fluorophenol

: 540-36-3
para-difluorobenzene

Conditions

Conditions	Yield
With 1,3-bis(2,6-diisopropylphenyl)-2,2-difluoro-2,3-dihydro-1h-imidazole; cesium fluoride; diphenylzinc In toluene at 110℃; for 20h; Product distribution / selectivity; Sealed vial;	78%
With 1,3-bis(2,6-diisopropylphenyl)-2,2-difluoro-2,3-dihydro-1h-imidazole; cesium fluoride In toluene at 23 - 110℃; for 20.5h; Inert atmosphere;	74 %Spectr.

: C6H4FN2(1+)*C8BF18(1-)

: sodium fluoride

A: 13755-29-8
sodium tetrafluoroborate

B: 540-36-3
para-difluorobenzene

C: 85794-30-5
C8F14

D: C8BF18(1-)*Na(1+)

E: C8BF18(1-)*Na(1+)

Conditions

Conditions	Yield
at 160 - 170℃; Glovebox;	A 17% B 77% C 3% D 65% E 12%

...Expand

: 1516885-17-8
C6H4FN2(1+)*C3BF6(1-)

: sodium fluoride

A: 13755-29-8
sodium tetrafluoroborate

B: 540-36-3
para-difluorobenzene

C: 1516885-27-0
C3BF6(1-)*Na(1+)

D: C3HF3*Na(1+)

Conditions

Conditions	Yield
at 160 - 170℃; Glovebox;	A 76% B 51% C 9% D 76%

...Expand

: 455-17-4
(p-fluorophenyl)trimethylsilane

: 540-36-3
para-difluorobenzene

Conditions

Conditions	Yield
With xenon difluoride In dichloromethane at 20℃; for 1h; Pyrex vessel;	73%
With lead(IV) acetate; boron trifluoride diethyl etherate Ambient temperature;	43 % Chromat.

: potassim 4-fluorophenyltrifluoroborate

A: 462-06-6
fluorobenzene

B: 540-36-3
para-difluorobenzene

Conditions

Conditions	Yield
With lithium hydroxide monohydrate; silver trifluoromethanesulfonate; Selectfluor In ethyl acetate at 55℃; Sealed tube;	A n/a B 65%

: 371-40-4
4-fluoroaniline

: 540-36-3
para-difluorobenzene

Conditions

Conditions	Yield
With sodium nitrite In Et3N-3HF	63.1%
With HF; sodium nitrite In tetrahydrofuran; ice-salt water	40%

: 363-72-4
Pentafluorobenzene

A: 540-36-3
para-difluorobenzene

B: 327-54-8
1,2,4,5-Tetrafluorobenzene

C: 367-23-7
1,2,4-trifluorobenzene

Conditions

Conditions	Yield
With C32H46N2Ru; sodium carbonate; isopropyl alcohol at 70℃; for 4h; Inert atmosphere; Schlenk technique; Glovebox;	A 7% B 60% C 21%

...Expand

: 1516885-12-3
C6H4FN2(1+)*C6BF8(1-)

A: 540-36-3
para-difluorobenzene

B: 363-72-4
Pentafluorobenzene

C: 434-90-2
decafluorobiphenyl

Conditions

Conditions	Yield
at 95 - 100℃;	A 54% B 24% C 16%

...Expand

: p-fluorophenyl-lead(IV) triacetate

: 109-63-7
trifluoroborane diethyl ether

A: 462-06-6
fluorobenzene

B: CH3COO(1-)*BF2(1+)=CH3COOBF2

C: 540-36-3
para-difluorobenzene

D: 301-04-2
lead acetate

Conditions

Conditions	Yield
Stirring of Pb-compd. in excess of BF3*Et2O overnight at room temp.; GC anal.;	A 7% B n/a C 49% D n/a

...Expand

: 132993-23-8
4-fluorophenyl trifluoromethanesulfonate

: 540-36-3
para-difluorobenzene

Conditions

Conditions	Yield
With 18-crown-6 ether; tetramethlyammonium chloride; cesium fluoride In acetonitrile at 60℃; for 16h; Glovebox;	49%

: 71-43-2
benzene

A: 462-06-6
fluorobenzene

B: 540-36-3
para-difluorobenzene

C: 367-11-3
ortho-difluorobenzene

D: 74298-20-7
3,3,6-trifluoro-1,4-cyclohexadiene

E: 74298-19-4
cis-3,6-difluorocyclohexadiene

F: 74298-17-2
trans,cis,trans-3,4,5,6-tetrafluorocyclohexene

Conditions

Conditions	Yield
With silver(II) fluoride In hexane at 40℃; for 0.2h; Product distribution; Mechanism; other solvents, times, temperatures, ratios;	A 47% B 2.3% C 1.9% D 6.3% E 4.1% F 7.4%

...Expand

: 327-54-8
1,2,4,5-Tetrafluorobenzene

A: 540-36-3
para-difluorobenzene

B: 367-23-7
1,2,4-trifluorobenzene

Conditions

Conditions	Yield
Stage #1: 1,2,4,5-Tetrafluorobenzene With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; [(HC[(CMe)N(2,4,6-Me3C6H2)]2)Al(H)2] In benzene-d6; benzene at 100℃; for 8h; Inert atmosphere; Glovebox; Sealed tube; Stage #2: With methanol In benzene-d6; benzene at 100℃; for 2h; Catalytic behavior; Inert atmosphere; Glovebox; Sealed tube; regioselective reaction;	A 19.5% B 47%

: 455-17-4
(p-fluorophenyl)trimethylsilane

: 546-67-8
lead(IV) tetraacetate

: 109-63-7
trifluoroborane diethyl ether

A: 462-06-6
fluorobenzene

B: 540-36-3
para-difluorobenzene

Conditions

Conditions	Yield
Stirring of silane with a slurry of Pb(OAc)4 in excess of BF3*Et2O overnight at room temp.; GC anal.;	A 0% B 43%

...Expand

: 352-33-0
1-Chloro-4-fluorobenzene

A: 540-36-3
para-difluorobenzene

B: 367-11-3
ortho-difluorobenzene

Conditions

Conditions	Yield
With Al2CuF8 at 500℃; Gas phase; Inert atmosphere;	A 42% B 11%

: 352-33-0
1-Chloro-4-fluorobenzene

A: 372-18-9
1,3-Difluorobenzene

B: 540-36-3
para-difluorobenzene

Conditions

Conditions	Yield
With Al2CuF8 at 500℃; Inert atmosphere;	A 11% B 42%

: 348-51-6
1-chloro-2-fluorobenzene

A: 462-06-6
fluorobenzene

B: 372-18-9
1,3-Difluorobenzene

C: 540-36-3
para-difluorobenzene

D: 367-11-3
ortho-difluorobenzene

Conditions

Conditions	Yield
With Al2CuF8 at 500℃; Gas phase; Inert atmosphere;	A 39% B 21% C 7% D 16%
With Al2CuF8 at 500℃; Inert atmosphere;	A 39% B 21% C 7% D 16%

...Expand

: 2367-82-0
1,2,3,5-tetrafluorobenzene

A: 1489-53-8
1,2,3-trifluorobenzene

B: 372-18-9
1,3-Difluorobenzene

C: 540-36-3
para-difluorobenzene

D: 367-11-3
ortho-difluorobenzene

E: 367-23-7
1,2,4-trifluorobenzene

Conditions

Conditions	Yield
Stage #1: 1,2,3,5-tetrafluorobenzene With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; [(HC[(CMe)N(2,4,6-Me3C6H2)]2)Al(H)2] In benzene-d6; benzene at 100℃; for 8h; Inert atmosphere; Glovebox; Sealed tube; Stage #2: With methanol In benzene-d6; benzene at 100℃; for 2h; Catalytic behavior; Inert atmosphere; Glovebox; Sealed tube; Overall yield = 69.5 %; regioselective reaction;	A 8.5% B 9.5% C 7% D 5.5% E 39%

...Expand

: 540-36-3
para-difluorobenzene

: 108-29-2
5-methyl-dihydro-furan-2-one

: 77263-70-8
5,8-difluoro-4-methyl-3,4-dihydronaphthalen-1(2H)-one

Conditions

Conditions	Yield
Stage #1: para-difluorobenzene; 5-methyl-dihydro-furan-2-one With aluminum (III) chloride Heating / reflux; Stage #2: With hydrogenchloride In water at 0℃;	100%
With aluminum (III) chloride for 16h; Heating / reflux;	81%
With aluminium trichloride for 16h; Heating;	55%

: 540-36-3
para-difluorobenzene

: 250665-62-4
1,1,4,4-tetrakis(trimethylsilyl)butane-1,4-diylsilylene

: 7,10-difluoro-1,1,4,4-tetrakis-trimethylsilanyl-5-sila-spiro[4.6]undeca-6,8,10-triene

Conditions

Conditions	Yield
Irradiation;	100%

: 540-36-3
para-difluorobenzene

: 364-74-9
1,4-difluoro-2-nitrobenzene

Conditions

Conditions	Yield
With sulfuric acid; nitric acid at 30 - 70℃; for 0.0333333h; Large scale;	98%
With 2C2H3F3O*BF3; potassium nitrate at 20℃; for 6h;	84%
With sulfuric acid; potassium nitrate at 5℃; Large scale;	83%

: 580-13-2
2-bromonaphthalene

: 540-36-3
para-difluorobenzene

: C16H10F2

Conditions

Conditions	Yield
With rubidium carbonate; 2,2-dimetyl-3-(adamantan-1-yl)propanoic acid; palladium dichloride In N,N-dimethyl acetamide at 60℃; for 40h; Inert atmosphere; Schlenk technique;	98%

: 540-36-3
para-difluorobenzene

: 4294-57-9
para-methylphenylmagnesium bromide

: 97295-31-3
1,4-bis(p-tolyl)benzene

Conditions

Conditions	Yield
With C35H31BrN4NiP In tetrahydrofuran at 25℃; for 13h; Schlenk technique; Inert atmosphere;	97%
With C26H24ClN2NiP*0.1C7H8 In toluene at 25℃; for 24h; Kumada Cross-Coupling; Schlenk technique; Inert atmosphere;	74%

: 540-36-3
para-difluorobenzene

: 13139-86-1
4-methoxyphenyl magnesium bromide

: 13021-19-7
4,4-dimethoxy-1,1':4',1-terphenyl

Conditions

Conditions	Yield
With C35H31BrN4NiP In tetrahydrofuran at 25℃; for 12h; Schlenk technique; Inert atmosphere;	97%

: 540-36-3
para-difluorobenzene

: 7353-91-5
4-dimethylaminophenylmagnesium bromide

: 34614-43-2
4-[4-(4-dimethylaminophenyl)phenyl]-N,N-dimethylaniline

Conditions

Conditions	Yield
With C35H31BrN4NiP In tetrahydrofuran at 25℃; for 12h; Schlenk technique; Inert atmosphere;	97%

: 932-31-0
ortho-tolylmagnesium bromide

: 540-36-3
para-difluorobenzene

: 53092-64-1
2,2”-dimethyl-1,1‘:4’,1“-terphenyl

Conditions

Conditions	Yield
With C35H31BrN4NiP In tetrahydrofuran at 70℃; for 22h; Schlenk technique; Inert atmosphere;	97%

: 75-15-0
carbon disulfide

: 540-36-3
para-difluorobenzene

: 100-39-0
benzyl bromide

: benzyl 2,5-difluorobenzodithioate

Conditions

Conditions	Yield
Stage #1: para-difluorobenzene With sec.-butyllithium; copper(l) cyanide In hexane; cyclohexane at -78℃; for 3h; Schlenk technique; Inert atmosphere; Stage #2: carbon disulfide In hexane; cyclohexane at -50 - 20℃; for 1h; Schlenk technique; Inert atmosphere; Stage #3: benzyl bromide In hexane; cyclohexane at 20℃; for 4h; Schlenk technique; Inert atmosphere;	97%

...Expand

: 540-36-3
para-difluorobenzene

: 135206-86-9
4-<(2S)-2-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)propionyl>morpholine

: 939439-00-6
(2S)-1-(2,5-difluoro-phenyl)-2-(tetrahydro-pyran-2-yloxy)-propan-1-one

Conditions

Conditions	Yield
Stage #1: para-difluorobenzene; 4-<(2S)-2-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)propionyl>morpholine With lithium diisopropyl amide In tetrahydrofuran; n-heptane at 0℃; for 2.333h; Stage #2: With ammonium chloride In tetrahydrofuran; n-heptane; water	96.2%

: 540-36-3
para-difluorobenzene

: 399-94-0
2-bromo-1,4-difluorobenzene

Conditions

Conditions	Yield
With N-Bromosuccinimide; boron trifluoride at 20℃; for 6h;	96%
With N-Bromosuccinimide; sulfuric acid at 30 - 40℃; for 1h; Large scale;	92.7%

: 558-37-2
tert-butylethylene

: 540-36-3
para-difluorobenzene

: C12H16F2

Conditions

Conditions	Yield
With sodium acetylacetonate; C107H126N2NiO2; sodium hydride In neat (no solvent) at 120℃; for 24h; Reagent/catalyst; regioselective reaction;	96%

: 610-94-6
2-bromobenzoic acid methyl ester

: 540-36-3
para-difluorobenzene

: C14H10F2O2

Conditions

Conditions	Yield
With rubidium carbonate; 2,2-dimetyl-3-(adamantan-1-yl)propanoic acid; palladium dichloride In N,N-dimethyl acetamide at 60℃; for 40h; Inert atmosphere; Schlenk technique;	96%

: 540-36-3
para-difluorobenzene

: [2,6-diisopropylbenzene-β-diketiminate]Nb(NtBu)(η6-C6H6)

: C39H54F2N3Nb

Conditions

Conditions	Yield
With trimethoxybenzene In benzene-d6 at 60℃; for 2h;	95%

: 5428-09-1
3-phthalimido-1-propene

: 540-36-3
para-difluorobenzene

: C17H11F2NO2

Conditions

Conditions	Yield
With silver(I) acetate; palladium diacetate In dimethyl sulfoxide at 130℃; for 4h; Sealed tube; regioselective reaction;	95%

: 540-36-3
para-difluorobenzene

: 90-11-9
1-Bromonaphthalene

: 1-(2,5-difluorophenyl)naphthalene

Conditions

Conditions	Yield
With rubidium carbonate; 2,2-dimetyl-3-(adamantan-1-yl)propanoic acid; palladium dichloride In N,N-dimethyl acetamide at 60℃; for 40h; Inert atmosphere; Schlenk technique;	95%

: 540-36-3
para-difluorobenzene

A: 367-27-1
2,4-difluorophenol

B: 2713-31-7
2,5-difluorophenol

Conditions

Conditions	Yield
With dihydrogen peroxide In acetonitrile at 60℃; for 0.416667h;	A 6% B 94%

: 540-36-3
para-difluorobenzene

: 100-52-7
benzaldehyde

: 149099-27-4, 149243-88-9, 365-22-0
4-fluorobenzhydrol

Conditions

Conditions	Yield
With calcium In tetrahydrofuran at -78℃; for 0.5h;	93%

: 118-29-6
2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione

: 540-36-3
para-difluorobenzene

: 2-(2,5-difluorobenzyl)isoindoline-1,3-dione

Conditions

Conditions	Yield
With trifluorormethanesulfonic acid Ambient temperature;	92%

: 540-36-3
para-difluorobenzene

: 100-52-7
benzaldehyde

: (2,5-difluorophenyl)(phenyl)methanol

Conditions

Conditions	Yield
Stage #1: para-difluorobenzene With n-butyllithium; N,N,N,N,-tetramethylethylenediamine In tetrahydrofuran; hexane at -71 - -68℃; for 1.5h; Stage #2: benzaldehyde In tetrahydrofuran; hexane at -71 - -68℃; for 1h;	92%

: 540-36-3
para-difluorobenzene

: phenylmagnesium bromide

: 92-94-4
[1,1';4',1'']terphenyl

Conditions

Conditions	Yield
With 1-[2-(diphenylphosphino)phenyl]ethanol; bis(acetylacetonate)nickel(II) In diethyl ether at 20℃; for 1h;	92%

: 540-36-3
para-difluorobenzene

: 100-58-3
phenylmagnesium bromide

: 92-94-4
[1,1';4',1'']terphenyl

Conditions

Conditions	Yield
Stage #1: para-difluorobenzene; phenylmagnesium bromide; 1-[2-(diphenylphosphino)phenyl]ethanol; bis(acetylacetonate)nickel(II) In diethyl ether for 1h; Stage #2: With methanol In diethyl ether Product distribution / selectivity;	92%
With nickel(II) chloride hexahydrate; C32H39N2OP In tetrahydrofuran at 25℃; for 20h; Kumada coupling reaction; Inert atmosphere;	92%
Stage #1: para-difluorobenzene; phenylmagnesium bromide; bis(acetylacetonate)nickel(II); ((2-hydroxymethyl)phenyl)diphenylphosphine In diethyl ether for 2h; Stage #2: With methanol In diethyl ether Product distribution / selectivity;	92 %Chromat.

: 540-36-3
para-difluorobenzene

: 64214-66-0
N-Methyl-N-methoxy-4-chlorobutanamide

: 1216260-42-2
4‐chloro‐1‐(2,5-difluorophenyl)butan-1-one

Conditions

Conditions	Yield
Stage #1: para-difluorobenzene With n-butyllithium In tetrahydrofuran at -70 - -60℃; for 3h; Stage #2: N-Methyl-N-methoxy-4-chlorobutanamide In tetrahydrofuran at -70 - 20℃; for 2h;	91.33%

: [(tris(3,5-dimethylpyrazolyl)borate)RhH2(PPhMe2)]

: 540-36-3
para-difluorobenzene

A: 1258937-61-9
[(tris(3,5-dimethylpyrazolyl)borate)RhH(κ2-C6H4-2-PMe2)]

B: 1258937-80-2
[Rh(tris(3,5-dimethylpyrazolyl)borate)H(2,5-C6F2H3)(PMe2Ph)]

Conditions

Conditions	Yield
In neat (no solvent) Irradiation (UV/VIS); (N2, Schlenk) a soln. of complex in fluorobenzene-compound in NMR tube was irradiated for 5 h, heated at 120°C for 1 h; flash chromy. (silica gel, 5:1 hexane-THF), washed with a min amount of ice-cold hexane; elem. anal.;	A n/a B 91%

...Expand

: 500-22-1
3-pyridinecarboxaldehyde

: 540-36-3
para-difluorobenzene

: (2,5-difluorophenyl)(pyridin-3-yl)methanol

Conditions

Conditions	Yield
Stage #1: para-difluorobenzene With n-butyllithium; N,N,N,N,-tetramethylethylenediamine In tetrahydrofuran at -70℃; Stage #2: 3-pyridinecarboxaldehyde In tetrahydrofuran at -70℃; for 1h;	90%

: 4746-97-8
cyclohexanedione monoethylene ketal

: 540-36-3
para-difluorobenzene

: 8-(2,5-difluorophenyl)-1,4-dioxaspiro[4.5]decan-8-ol

Conditions

Conditions	Yield
Stage #1: para-difluorobenzene With n-butyllithium; N,N,N,N,-tetramethylethylenediamine In tetrahydrofuran at -70℃; Stage #2: cyclohexanedione monoethylene ketal In tetrahydrofuran at -70℃; for 1h;	90%

1,4-Difluorobenzene Chemical Properties

IUPAC Name: 1,4-Difluorobenzene
Synonyms of 1,4-Difluorobenzene (CAS NO.540-36-3): p-Difluorobenzene ; para-Difluorobenzene ; Benzene, 1,4-difluoro- ; Benzene, 1,4-difluoro- (9CI) ; Benzene, p-difluoro-
CAS NO: 540-36-3
Molecular Formula: C₆H₄F₂
Molecular Weight : 114.0928
Molecular Structure:
EINECS: 208-742-9
H bond acceptors: 0
H bond donors: 0
Freely Rotating Bonds: 0
Polar Surface Area: Å²
Index of Refraction: 1.448
Molar Refractivity: 26.24 cm³
Molar Volume: 97.8 cm³
Melting Point: -13 °C
Surface Tension: 26.2 dyne/cm
Density: 1.165 g/cm³
Flash Point: 2.1 °C
Enthalpy of Vaporization: 31.77 kJ/mol
Boiling Point: 90.4 °C at 760 mmHg
Vapour Pressure: 63.6 mmHg at 25°C
Storage temp: Flammables area
Appearance: 1,4-Difluorobenzene (CAS NO.540-36-3) is clear colorless to light yellow liquid .
Product Categories: Aromatic Hydrocarbons (substituted) & Derivatives;Fluorobenzene;Aryl;C6;Halogenated Hydrocarbons;Method 8020;600 Series Wastewater Methods;8000 Series Solidwaste Methods;FluoroEPA;Method 624EPA;Alpha Sort;D;DAlphabetic;DID - DINChemical Class;Fluoro;Halogenated;Volatiles/ Semivolatiles

1,4-Difluorobenzene Uses

1,4-Difluorobenzene (CAS NO.540-36-3) is used as intermediates of medicine, pesticide and liquid crystal .

1,4-Difluorobenzene Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LC50	inhalation	55gm/m3/2H (55000mg/m3)	BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS	Izvestiya Sibirskogo Otdeleniya Akademii Nauk SSSR, Seriya Biologomeditsinskikh Nauk. Vol. 3, Pg. 91, 1965.

1,4-Difluorobenzene Safety Profile

Hazard Codes:F, Harmful Xn, Toxic T
Risk Statements: 11-20-39/23/24/25
R11: Highly flammable.
R20: Harmful by inhalation.
R39/23/24/25: Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed
Safety Statements: 16-29-33-45-36/37-7/9
S7/9: Keep container tightly closed and in a well-ventilated place
S16: Keep away from sources of ignition.
S33:Take precautionary measures against static discharges.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S36/37: Wear suitable protective clothing and gloves.
RIDADR: UN 1993 3/PG 2
WGK Germany: 3
RTECS: CZ5658000
Hazard Note: Highly Flammable
HazardClass: 3
PackingGroup: II
HS Code: 29036990

1,4-Difluorobenzene Specification

Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Will burn if involved in a fire. Flammable liquid and vapor.
Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam.
Handling: Use spark-proof tools and explosion proof equipment. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.
Storage: Keep away from sources of ignition. Store in a cool, dry place. Keep container closed when not in use. Flammables-area.

Product Name

1,4-Difluorobenzene

Synthetic route

1,4-Difluorobenzene Chemical Properties

1,4-Difluorobenzene Uses

1,4-Difluorobenzene Toxicity Data With Reference

1,4-Difluorobenzene Safety Profile

1,4-Difluorobenzene Specification

Related Products

Hot Products