1-Naphthoic acid supplier

Name
1-Naphthoic acid
EINECS 201-681-9
CAS No. 86-55-5
Article Data335
CAS DataBase
Density 1.265 g/cm³
Solubility Freely soluble in hot alcohol and ether. Slightly soluble in hot water.
Melting Point 157-160 °C(lit.)
Formula C₁₁H₈O₂
Boiling Point 300 °C at 760 mmHg
Molecular Weight 172.183
Flash Point 164.6 °C
Transport Information
Appearance off-white to beige powder
Safety 26-36-24/25-37
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms 1-Carboxynaphthalene;alpha-Naphthoic acid;naphthalene-1-carboxylate;alpha-Naphthylcarboxylic acid;1-Naphthoicacid;naphthalene-1-carboxylic acid;Naphthalene-alpha-carboxylic acid;1-naphthalenecarboxylic acid;.alpha.-Naphthoic acid;
PSA 37.30000
LogP 2.53800

Synthetic route

: 81-84-5
1,8-Naphthalic anhydride

: 86-55-5
1-naphthalenecarboxylic acid

Conditions

Conditions	Yield
Stage #1: 1,8-Naphthalic anhydride With sodium hydroxide In water at 100℃; for 0.0166667h; microwave irradiation; Stage #2: With mercury(II) diacetate In water at 200℃; for 0.25h; Pesci reaction; microwave irradiation; Stage #3: With hydrogenchloride In water at 120℃; for 0.25h; microwave irradiation;	100%

: 201230-82-2
carbon monoxide

: 90-11-9
1-Bromonaphthalene

: 86-55-5
1-naphthalenecarboxylic acid

Conditions

Conditions	Yield
With sodium hydroxide; cobalt(II) acetate In ethanol at 65℃; under 1520 Torr; for 4h; Irradiation;	99.3%
With sodium hydroxide; tetrabutylammomium bromide; dicobalt octacarbonyl In water; benzene at 65℃; under 760 Torr; for 5h; Irradiation;	96%
With tetrabutylammomium bromide; dicobalt octacarbonyl In sodium hydroxide; benzene at 65℃; for 4.5h; Irradiation;	95%
With tributyl-amine; water; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride at 110 - 130℃; under 3 Torr; for 24h;	48%
With water; sodium acetate; triethylamine; Pd-bis(1-methylbenzothiazole-2-carbene) In N,N-dimethyl acetamide at 130℃; for 7h;	55 % Chromat.

: 66-77-3
1-naphthaldehyde

: 86-55-5
1-naphthalenecarboxylic acid

Conditions

Conditions	Yield
With copper acetylacetonate; oxygen; sodium hydroxide; 1,3-bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene In water at 50℃; under 760.051 Torr; for 12h; Sealed tube;	99%
With C4H11FeMo6NO24(3-)*3C16H36N(1+); water; oxygen; sodium carbonate at 50℃; under 760.051 Torr; for 8h; Green chemistry;	99%
With 2-mesityl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-2-ium tetrafluoroborate; 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine In acetonitrile at 20℃;	98%

: (1-nosyl-5-nitroindol-3-yl)methyl 1-naphthoate

: 86-55-5
1-naphthalenecarboxylic acid

Conditions

Conditions	Yield
Stage #1: (1-nosyl-5-nitroindol-3-yl)methyl 1-naphthoate With 2-(N,N-dimethylamino)ethylthiol hydrochloride; 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 20℃; for 0.25h; Inert atmosphere; Stage #2: With hydrogenchloride In diethyl ether; water; acetonitrile Inert atmosphere;	99%

: 53422-19-8
benzyl 1-naphthoate

: 108-88-3
toluene

A: 86-55-5
1-naphthalenecarboxylic acid

B: 620-47-3
1-methyl-3-(phenylmethyl)-benzene

C: 620-83-7
1-methyl-4-(phenylmethyl)benzene

D: 713-36-0
2-benzyltoluene

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate; water at 80℃; for 2h; regioselective reaction;	A 99% B n/a C n/a D n/a

...Expand

: 90-11-9
1-Bromonaphthalene

: 6482-39-9
sodium methyl carbonate

: 86-55-5
1-naphthalenecarboxylic acid

Conditions

Conditions	Yield
Stage #1: 1-Bromonaphthalene With iodine; magnesium In tetrahydrofuran at 60℃; for 17.25h; Inert atmosphere; Stage #2: sodium methyl carbonate In tetrahydrofuran at 20℃; for 24h; Inert atmosphere;	99%

: 124-38-9
carbon dioxide

: 321-38-0
1-Fluoronaphthalene

: 86-55-5
1-naphthalenecarboxylic acid

Conditions

Conditions	Yield
Stage #1: 1-Fluoronaphthalene With C78H70Al2Cl4N6P4Rh2; magnesium; ethylene dibromide In tetrahydrofuran at 20℃; for 22h; Inert atmosphere; Glovebox; Stage #2: carbon dioxide In tetrahydrofuran at 20℃; under 760.051 Torr; for 0.5h; Reagent/catalyst; Temperature;	99%

: 4780-79-4
1-naphthalene methanol

: 86-55-5
1-naphthalenecarboxylic acid

Conditions

Conditions	Yield
With N-Bromosuccinimide; oxygen In acetonitrile at 20℃; for 10h; Irradiation;	97%
With periodic acid; pyridinium chlorochromate In acetonitrile	96%
With tert.-butylhydroperoxide; manganese(II) acetate; trifluoroacetic acid In acetonitrile at 80℃; under 15001.5 Torr; for 13h; Mechanism; chemoselective reaction;	95%

: 15226-74-1, 61091-28-9, 61117-58-6
dicobalt octacarbonyl

: 99747-74-7
1-naphthyl triflate

: 86-55-5
1-naphthalenecarboxylic acid

Conditions

Conditions	Yield
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate In 1,4-dioxane; water at 20℃; for 16h; Schlenk technique; Inert atmosphere; chemoselective reaction;	97%

: 64-18-6
formic acid

: 90-14-2
1-Iodonaphthalene

: 86-55-5
1-naphthalenecarboxylic acid

Conditions

Conditions	Yield
With palladium diacetate; triethylamine; dicyclohexyl-carbodiimide; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In N,N-dimethyl-formamide at 100℃; for 20h; Inert atmosphere; Sealed tube;	97%
With palladium diacetate; triethylamine; dicyclohexyl-carbodiimide; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In N,N-dimethyl-formamide at 80℃; for 10h; Inert atmosphere; Sealed tube;	75%

: 2-(azulen-6-yl)ethyl 1-naphthoate

: 86-55-5
1-naphthalenecarboxylic acid

Conditions

Conditions	Yield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 20℃; for 3h;	97%

: 124-38-9
carbon dioxide

: 90-11-9
1-Bromonaphthalene

: 86-55-5
1-naphthalenecarboxylic acid

Conditions

Conditions	Yield
With potassium; potassium iodide; magnesium chloride In tetrahydrofuran 1.) reflux, 1 h, 2.) -3 deg C, 4.5 h;	96%
With C26H30B10Cl2P2Pd In toluene at 50℃; under 760.051 Torr; for 10h;	91%
With diethylzinc; palladium diacetate; tert-butyl XPhos In hexanes; N,N-dimethyl acetamide at 40℃; under 7600.51 Torr; Automated synthesizer;	69%
With manganese; 2.9-dimethyl-1,10-phenanthroline; lithium acetate; cobalt(II) bromide In N,N-dimethyl acetamide at 20℃; under 760.051 Torr; for 12h; Inert atmosphere; Schlenk technique;	68%
With 6,6'-dimethyl-2,2'-bipyridine; lithium chloride; cobalt(II) iodide; zinc In N,N-dimethyl-formamide; acetonitrile at 40℃; under 760.051 Torr; for 14h; Sealed tube;	46%

: 15226-74-1, 61091-28-9, 61117-58-6
dicobalt octacarbonyl

: naphthalen-1-yl 2,3,4,5,6-pentafluorobenzenesulfonate

: 86-55-5
1-naphthalenecarboxylic acid

Conditions

Conditions	Yield
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate In 1,4-dioxane; water at 20℃; for 16h; Schlenk technique; Inert atmosphere; chemoselective reaction;	96%

: 4-((tert-butyldimethylsilyl)oxy)benzyl 1-naphthoate

: 86-55-5
1-naphthalenecarboxylic acid

Conditions

Conditions	Yield
With tetrabutyl ammonium fluoride In tetrahydrofuran at 20℃; for 0.5h;	95%

: 201230-82-2
carbon monoxide

: 90-13-1
1-Chloronaphthalene

: 86-55-5
1-naphthalenecarboxylic acid

Conditions

Conditions	Yield
With dicobalt octacarbonyl; potassium carbonate; methyloxirane In methanol at 60℃; under 760 Torr; for 2.5h;	92%
With potassium hydroxide; (bis(tricyclohexyl)phosphine)palladium(II) dichloride In water for 72h; Heating;	10300 % Turnov.
With dicobalt octacarbonyl; potassium carbonate; benzyl chloride at 60℃; under 760 Torr; for 0.5h; carbonylation of aryl bromides, relative reactivity, effect of cocatalysts;

: 86-87-3
naphth-1-yl acetic acid

: 86-55-5
1-naphthalenecarboxylic acid

Conditions

Conditions	Yield
With dihydrogen peroxide In water; acetonitrile at 25℃; for 10h; UV-irradiation;	92%
With iodine; dimethyl sulfoxide at 120℃; for 26h; Sealed tube; Green chemistry;	88%

: 76580-08-0
1-(4-methoxyphenyl)-2-(naphthalen-1-yl)ethan-1-one

A: 86-55-5
1-naphthalenecarboxylic acid

B: 100-09-4
4-methoxybenzoic acid

Conditions

Conditions	Yield
With oxygen; potassium hydroxide at 20℃; Schlenk technique; chemoselective reaction;	A 92% B 92%

: 201230-82-2
carbon monoxide

: 99747-74-7
1-naphthyl triflate

: 86-55-5
1-naphthalenecarboxylic acid

Conditions

Conditions	Yield
With potassium acetate; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate In dimethyl sulfoxide at 60℃; for 3h;	90%

: 201230-82-2
carbon monoxide

: 90-14-2
1-Iodonaphthalene

: 86-55-5
1-naphthalenecarboxylic acid

Conditions

Conditions	Yield
With 4,4’‐bis(trimethylammoniummethyl)‐2,2’‐bipyridine; bis-triphenylphosphine-palladium(II) chloride; water; sodium carbonate In water at 100℃; under 7600.51 Torr; for 24h; Catalytic behavior; Autoclave;	90%
With water; palladium diacetate; potassium carbonate at 20℃; under 760.051 Torr; for 5h;	87%
With water; potassium carbonate In acetonitrile at 100℃; under 3750.38 Torr; for 0.0161111h;	87%
With water; palladium diacetate; triethylamine; triphenylphosphine In 1,4-dioxane at 110℃; under 11251.1 Torr; for 2h; Flow reactor;	43%

: 201230-82-2
carbon monoxide

: 90-11-9
1-Bromonaphthalene

A: 86-55-5
1-naphthalenecarboxylic acid

B: 6341-54-4
1-naphthylglycolic acid

C: 26153-26-4
1-naphthylglyoxylic acid

Conditions

Conditions	Yield
With methyl iodide; sodium sulfide In water; isopropyl alcohol at 20℃; for 20h;	A 6% B 3% C 89%
With methyl iodide; sodium sulfide In water; isopropyl alcohol at 60℃; for 20h;	A 60% B 17% C 20%
With sodium sulfide; CoCl2 In 1,4-dioxane; water at 20℃; for 20h; Product distribution; other reag.; other solvent;	A 4 % Chromat. B 9 % Chromat. C 86 % Chromat.

...Expand

: 90-14-2
1-Iodonaphthalene

: 556-63-8
lithium formate

: 86-55-5
1-naphthalenecarboxylic acid

Conditions

Conditions	Yield
With acetic anhydride; N-ethyl-N,N-diisopropylamine; lithium chloride; palladium on activated charcoal In N,N-dimethyl-formamide at 100℃; for 10h;	89%
Stage #1: lithium formate With acetic anhydride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; Stage #2: 1-Iodonaphthalene With tris(dibenzylideneacetone)dipalladium (0); lithium chloride In N,N-dimethyl-formamide at 80℃; for 6h;	82%

: 84812-40-8
(±)-1,2-di(naphthalen-1-yl)ethane-1,2-diol

: 86-55-5
1-naphthalenecarboxylic acid

Conditions

Conditions	Yield
With sodium hypochlorite In acetonitrile at 20℃; for 18h;	89%

: 124-38-9
carbon dioxide

: 1-lithiothionaphthalene*TMEDA complex

: 86-55-5
1-naphthalenecarboxylic acid

Conditions

Conditions	Yield
In Petroleum ether -100 deg C to 0 deg C;	88%

: 85924-97-6
1H-cyclobutanaphthalen-1-one

: 86-55-5
1-naphthalenecarboxylic acid

Conditions

Conditions	Yield
With potassium hydroxide In N,N,N,N,N,N-hexamethylphosphoric triamide for 3.5h; further reagents;	88%

: 2459-24-7
methyl 1-naphthoate

: 86-55-5
1-naphthalenecarboxylic acid

Conditions

Conditions	Yield
With potassium hydroxide In methanol at 35℃; for 1h;	87%
With tetramethyl ammoniumhydroxide In water; dimethyl sulfoxide at 83.3℃; Rate constant; substituents polar effects;

: 124-38-9
carbon dioxide

: 90-14-2
1-Iodonaphthalene

: 86-55-5
1-naphthalenecarboxylic acid

Conditions

Conditions	Yield
With 3,4-benzo-1,1,2,2-tetraethyl-1,2-disilacyclobut-3-ene; cesium fluoride In N,N-dimethyl-formamide at 0 - 20℃; under 760.051 Torr; for 2h;	87%
With copper(l) iodide; diethylzinc; N,N`-dimethylethylenediamine In dimethyl sulfoxide at 70℃; under 760.051 Torr;	68%

: C26H18N2O6S

: 108-98-5
thiophenol

A: 56366-43-9
3-<(phenylthio)methyl>-1H-indole

B: 86-55-5
1-naphthalenecarboxylic acid

C: 4171-83-9
2-nitrophenyl phenyl sulfide

Conditions

Conditions	Yield
With caesium carbonate In acetonitrile Inert atmosphere;	A 84% B 82% C 86%

...Expand

: 605-78-7
bis(naphthalen-1-yl)methanone

A: 91-20-3
naphthalene

B: 86-55-5
1-naphthalenecarboxylic acid

Conditions

Conditions	Yield
With potassium hydroxide In 1,2-dimethoxyethane	A 70% B 85%

: 3457-41-8
1,2-bis(naphthalen-1-yl)ethane-1,2-dione

: 86-55-5
1-naphthalenecarboxylic acid

Conditions

Conditions	Yield
With sodium hypochlorite In acetonitrile at 20℃; for 1.5h;	85%
With 2-(3-thiazolium)-1-phenylethanone bromide; triethylamine In dimethyl sulfoxide; acetonitrile at 37℃; Acidic conditions;

: 57605-95-5
1-(1-naphthyl)ethanol

: 86-55-5
1-naphthalenecarboxylic acid

Conditions

Conditions	Yield
With sodium nitrate; water; oxygen In dimethyl sulfoxide at 130℃; for 36h;	85%

: 86-55-5
1-naphthalenecarboxylic acid

: 879-18-5
naphthalene-1-carbonic acid chloride

Conditions

Conditions	Yield
With thionyl chloride In toluene for 2h; Reflux;	100%
With thionyl chloride for 2h; Heating / reflux;	98%
With thionyl chloride for 2h; Heating;	98%

: 86-55-5
1-naphthalenecarboxylic acid

: 75-03-6
ethyl iodide

: 3007-97-4
ethyl 1-naphthoate

Conditions

Conditions	Yield
With caesium carbonate In acetonitrile for 1.5h; Heating;	100%
With caesium carbonate In acetonitrile at 20℃; for 1.5h; Reflux; Inert atmosphere;	79%
With caesium carbonate In acetonitrile at 20℃; for 90h; Reflux; Inert atmosphere;	79%
With 18-crown-6 ether; potassium carbonate In tetrahydrofuran for 21h; Inert atmosphere; Reflux;

: 86-55-5
1-naphthalenecarboxylic acid

: 257299-95-9
[(1R,3S)-5-Iodo-6,8-dimethoxy-1-methyl-2-(toluene-4-sulfonyl)-1,2,3,4-tetrahydro-isoquinolin-3-yl]-methanol

: 1248682-79-2
((1R,3S)-5-iodo-6,8-dimethoxy-1-methyl-2-tosyl-1,2,3,4-tetrahydroisoquinolin-3-yl)methyl 1-naphthoate

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃; Inert atmosphere;	100%

: 86-55-5
1-naphthalenecarboxylic acid

: 6240-39-7, 7384-42-1, 15177-65-8, 20698-65-1
cis-cis-decahydro-1-naphthoic acid

Conditions

Conditions	Yield
With platinum(IV) oxide; hydrogen In acetic acid under 3000.3 Torr;	100%

: 86-55-5
1-naphthalenecarboxylic acid

: 169447-94-3
1-[(1,1-dimethylethoxy)carbonyl]-2(S)-(2-methoxyethyl)piperazine

: 175357-63-8
1-[(1,1-dimethylethoxy)carbonyl]-2(S)-(2-methoxyethyl)-4-(1-naphthalenylcarbonyl)piperazine

Conditions

Conditions	Yield
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 16h; Acylation;	99%

: 110-89-4
piperidine

: 86-55-5
1-naphthalenecarboxylic acid

: 5454-14-8
(naphthalen-1-yl)(piperidin-1-yl)methanone

Conditions

Conditions	Yield
With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃;	99%

: 86-55-5
1-naphthalenecarboxylic acid

: (6RS,11aSR)-6-hydroxymethyl-9-methyl-3-(3-methyl-2,4,5-trimethoxybenzylidene)-2,3,11,11a-tetrahydro-7,8,10-trimethoxy-6H-pyrazino[1,2-b]isoquinoline-1,4-dione

: (6RS,11aSR)-6-(1-naphthylcarbonyloxymethyl)-9-methyl-3-(3-methyl-2,4,5-trimethoxybenzylidene)-2,3,11,11a-tetrahydro-7,8,10-trimethoxy-6H-pyrazino[1,2-b]isoquinoline-1,4-dione

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 21h; Inert atmosphere;	99%

: 100-41-4
ethylbenzene

: 86-55-5
1-naphthalenecarboxylic acid

: 1375008-87-9
1-phenylethyl 1-naphthoate

Conditions

Conditions	Yield
With tetra-(n-butyl)ammonium iodide In water at 80℃; for 3h;	99%

: 86-55-5
1-naphthalenecarboxylic acid

: 1117-97-1
N,0-dimethylhydroxylamine

: naphthalene-1-(N-methoxy-N-methyl)carboxamide

Conditions

Conditions	Yield
Stage #1: 1-naphthalenecarboxylic acid; N,0-dimethylhydroxylamine In toluene at 0℃; for 0.166667h; Stage #2: With phosphorus trichloride In toluene at 20 - 60℃; for 0.5h;	99%

: 86-55-5
1-naphthalenecarboxylic acid

: 616-38-6
carbonic acid dimethyl ester

: 2459-24-7
methyl 1-naphthoate

Conditions

Conditions	Yield
With 25 wt percent zeolite NaY-Bf at 200℃; for 5h; Autoclave; Green chemistry;	99%
With dimanganese decacarbonyl at 180℃; for 1h; Sealed tube;	97%

: 67-56-1
methanol

: 86-55-5
1-naphthalenecarboxylic acid

: 2459-24-7
methyl 1-naphthoate

Conditions

Conditions	Yield
With thionyl chloride at 0 - 40℃; for 1h;	98.5%
With oxone at 65℃; for 30h;	92%
With sulfuric acid at 65℃; for 2h;	91%

: 86-55-5
1-naphthalenecarboxylic acid

: 1219733-88-6
C18H22N4O4

: 1219733-90-0
C29H28N4O5

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 20h;	98.1%

: 86-55-5
1-naphthalenecarboxylic acid

: 78-39-7
Triethyl orthoacetate

: 3007-97-4
ethyl 1-naphthoate

Conditions

Conditions	Yield
With 3-butyl-1-methyl-1H-imidazol-3-ium hexafluorophosphate at 80℃; for 1.66667h;	98%
In various solvent(s) at 80℃; for 1.66667h;	98%
In toluene at 110℃; for 24h;	89%

: 86-55-5
1-naphthalenecarboxylic acid

: 2243-81-4
1-naphthylcarboxamide

Conditions

Conditions	Yield
With pyridine; ammonium bicarbonate; di-tert-butyl dicarbonate In 1,4-dioxane at 20℃;	98%
Stage #1: 1-naphthalenecarboxylic acid With 1,3,5-trichloro-2,4,6-triazine; potassium carbonate In tetrahydrofuran for 0.0166667h; Milling; Stage #2: With ammonium thiocyanate In tetrahydrofuran for 0.0833333h; Milling;	90%
With ammonium carbonate; ortho-tungstic acid; silver(l) oxide In 5,5-dimethyl-1,3-cyclohexadiene at 160℃; for 8h;	82.4%

: 86-55-5
1-naphthalenecarboxylic acid

: potassium phenyltrifluoborate

: 108981-94-8
2-phenyl-1-naphthalenecarboxylic acid

Conditions

Conditions	Yield
With dipotassium hydrogenphosphate; oxygen; palladium diacetate; p-benzoquinone In tert-butyl alcohol at 100℃; under 22801.5 Torr; for 24h;	98%

: 86-55-5
1-naphthalenecarboxylic acid

: (3RS,6RS,11aSR)-6-hydroxymethyl-9-methyl-3-(3-methyl-2,4,5-trimethoxy-benzyl)-2,3,11,11a-tetrahydro-7,8,10-trimethoxy-6H-pyrazino[1,2-b]isoquinoline-1,4-dione

: (3RS,6RS,11aSR)-6-(1-naphthylcarbonyloxymethyl)-9-methyl-3-(3-methyl-2,4,5-trimethoxybenzyl)-2,3,11,11a-tetrahydro-7,8,10-trimethoxy-6H-pyrazino[1,2-b]isoquinoline-1,4-dione

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 21h; Inert atmosphere;	98%

: 86-55-5
1-naphthalenecarboxylic acid

: 75-26-3
isopropyl bromide

: 1202873-28-6
1-isopropyl-1,4-dihydronaphthalene-1-carboxylic acid

Conditions

Conditions	Yield
Stage #1: 1-naphthalenecarboxylic acid With ammonia; lithium In water at -60℃; for 0.5h; Birch reduction; Stage #2: isopropyl bromide With tert-butyl alcohol In water regioselective reaction;	98%
Stage #1: 1-naphthalenecarboxylic acid With ammonia; lithium at -78℃; for 1h; Stage #2: isopropyl bromide at -78℃; for 0.25h;
With ammonia; lithium at -78℃; for 1.25h; Birch Reduction;

: 86-55-5
1-naphthalenecarboxylic acid

: 593-56-6
N-methoxylamine hydrochloride

: 52288-24-1
N-methoxynaphthalene-1-carboxamide

Conditions

Conditions	Yield
Stage #1: 1-naphthalenecarboxylic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 0 - 20℃; for 4h; Under an atmosphere of argon; Stage #2: N-methoxylamine hydrochloride With potassium carbonate In water; ethyl acetate at 0 - 20℃; for 4h;	98%
With 1,1'-carbonyldiimidazole In tetrahydrofuran at 20℃;	75%
Stage #1: 1-naphthalenecarboxylic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 0 - 20℃; for 3.5h; Stage #2: N-methoxylamine hydrochloride With potassium carbonate In water; ethyl acetate at 20℃; for 20h;

: 86-55-5
1-naphthalenecarboxylic acid

: 110-83-8
cyclohexene

: 1383677-49-3
cyclohex-2-en-1-yl 1-naphthoate

Conditions

Conditions	Yield
With di-tert-butyl peroxide; C11H23N2(1+)*Br4Fe(1-) In ethyl acetate at 110℃; for 24h;	98%
With tert.-butylhydroperoxide; tetra-(n-butyl)ammonium iodide In benzene at 80℃; for 8h;	77%

: 86-55-5
1-naphthalenecarboxylic acid

: 126070-20-0
4-((tert-butyldimethylsilyloxy)methyl)phenol

: 4-(((tert-butyldimethylsilyl)oxy)methyl)phenyl naphthoate

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In acetonitrile at 20℃; for 1h; Inert atmosphere; Schlenk technique;	98%

: 86-55-5
1-naphthalenecarboxylic acid

: 2,2'-dimethyl-[1,1'-biphenyl]iodonium trifluoromethanesulfonate salt

: C25H19IO2

Conditions

Conditions	Yield
With copper diacetate; sodium carbonate; (3aR,3a'R,8aS,8a'S)-2,2'-(propane-2,2-diyl)bis(8,8a-dihydro-3aH-indeno[1,2-d]oxazole) In dichloromethane; water at 30℃; for 12h; enantioselective reaction;	98%

: 86-55-5
1-naphthalenecarboxylic acid

: 92151-73-0
2-phenylethynylphenol

: 2-(2-phenylacetyl)phenyl 1-naphthoate

Conditions

Conditions	Yield
Stage #1: 1-naphthalenecarboxylic acid; 2-phenylethynylphenol With bis(1,5-cyclooctadiene)diiridium(I) dichloride In dichloromethane at 20℃; for 1h; Stage #2: With silica gel regioselective reaction;	98%

: 86-55-5
1-naphthalenecarboxylic acid

: 162046-50-6
tert-butyl 2-aminobenzylcarbamate

: tert-butyl N-{[2-(naphthalene-1-amido)phenyl]methyl}carbamate

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 24h;	98%

1-Naphthoic acid Consensus Reports

Reported in EPA TSCA Inventory.

1-Naphthoic acid Specification

1-Naphthoic acid, with the CAS NO.86-55-5, is also named as 1-Naphthalenecarboxylic acid, 1-Carboxynaphthalene, alpha-Naphthoic acid, naphthalene-1-carboxylic acid, NAPHTHOIC ACID. It belongs to the ProductCategories of Aromatic Compounds; Naphthalene derivatives; Organic acids. 1-Naphthoic acid can be used in organic synthesis.

Physical properties about 1-Naphthoic acid are: (1)ACD/LogP: 3.13±0.21; (2)ACD/LogD (pH 5.5): 1.14; (3)ACD/LogD (pH 7.4): 0.05; (4)ACD/BCF (pH 5.5): 1.45; (5)ACD/BCF (pH 7.4): 1.00; (6)ACD/KOC (pH 5.5): 12.40; (7)ACD/KOC (pH 7.4): 1.00; (8)#H bond acceptors: 2; (9)#H bond donors: 1; (10)#Freely Rotating Bonds: 1; (11)Index of Refraction: 1.673; (12)Molar Refractivity: 51.0±0.3 cm³; (13)Molar Volume: 136.1±3.0 cm³; (14)Polarizability: 20.2±0.5 10-24cm³; (15)Surface Tension: 56.6±3.0 dyne/cm; (16)Density: 1.3±0.1 g/cm³; (17)Flash Point: 164.6±13.9 °C; (18)Enthalpy of Vaporization: 57.0±3.0 kJ/mol; (19)Boiling Point: 299.999 °C at 760 mmHg; (20)Vapour Pressure: 0.0±0.6 mmHg at 25°C

When you are using this chemical, please be cautious about it as the following:
1. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice;
2. Wear suitable protective clothing;
3. Avoid contact with skin and eyes;
4. Wear suitable gloves;

You can still convert the following datas into molecular structure:
(1)InChI=1S/C11H8O2/c12-11(13)10-7-3-5-8-4-1-2-6-9(8)10/h1-7H,(H,12,13);
(2)InChIKey=LNETULKMXZVUST-UHFFFAOYSA-N;
(3)Smilesc12c(cccc1C(O)=O)cccc2;

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	oral	2370mg/kg (2370mg/kg)		National Technical Information Service. Vol. PB85-143766,

Product Name

1-Naphthoic acid

Synthetic route

1-Naphthoic acid Consensus Reports

1-Naphthoic acid Specification

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