2,4-Dimethylphenol supplier

Name
2,4-Xylenol
EINECS 203-321-6
CAS No. 105-67-9
Article Data161
CAS DataBase
Density 1.014 g/cm³
Solubility 0.5 g/100 mL (25 ºC) in water
Melting Point 22-23 ºC
Formula C₈H₁₀O
Boiling Point 210.9 ºC at 760 mmHg
Molecular Weight 122.167
Flash Point 85.6 ºC
Transport Information UN 2261 6.1/PG 2
Appearance clear colorless to yellow liquid
Safety 26-36/37/39-45-61-36/37-16-7
Risk Codes 24/25-34-51/53-39/23/24/25-23/24/25-11
Molecular Structure
Hazard Symbols T,N,F
Synonyms 2,4-Xylenol(8CI);1-Hydroxy-2,4-dimethylbenzene;2,4-DMP;2,4-Dimethylphenol;4,6-Dimethylphenol;4-Hydroxy-1,3-dimethylbenzene;Phenol,2,4-dimethyl-;m-Xylenol;2,4-Dimethylphenol;
PSA 20.23000
LogP 2.00900

Synthetic route

: 16414-81-6
1,3-dimethyl-4-trimethylsilyloxybenzene

: 105-67-9
2,4-Xylenol

Conditions

Conditions	Yield
With methanol; 1,3-disulfonic acid imidazolium hydrogen sulfate at 20℃; for 0.0666667h; Green chemistry;	96%
With Nanoporous Na+-Montmorillonite Perchloric Acid In ethanol at 20℃; for 0.0833333h;	92%
With caro's acid; silica gel In dichloromethane at 20℃; for 0.333333h;	90%
With methanol at 20℃; for 0.116667h;	87%

: 583-70-0
1-bromo-2,4-dimethylbenzene

: 105-67-9
2,4-Xylenol

Conditions

Conditions	Yield
Stage #1: 1-bromo-2,4-dimethylbenzene With copper(l) iodide; cesium hydroxide; 5-bromo-2-(1H-imidazol-2-yl)pyridine In water; dimethyl sulfoxide; tert-butyl alcohol at 120℃; for 36h; Inert atmosphere; Stage #2: With hydrogenchloride In water; dimethyl sulfoxide; tert-butyl alcohol pH=1 - 2; Inert atmosphere;	90%
With cesiumhydroxide monohydrate; t-BuBrettPhos; C44H62NO5PPdS; water In 1,4-dioxane at 20℃; for 18h; Time; Solvent; Inert atmosphere;	71%
With N1,N2-bis(thiophen-2-ylmethyl)oxalamide; caesium carbonate; copper(I) bromide; sodium hydroxide In water; dimethyl sulfoxide at 85℃; for 20h; Reagent/catalyst; Temperature; Glovebox; Schlenk technique; Sealed tube; Inert atmosphere; chemoselective reaction;

: 108-38-3
m-xylene

: 105-67-9
2,4-Xylenol

Conditions

Conditions	Yield
With dihydrogen peroxide; bis(triphenyl)oxodiphosphonium trifluoromethanesulfonate salt In ethanol; water at 20℃; for 0.666667h;	78%
With hydrogen fluoride; oxygen; arsenic(III) trioxide at 120℃; under 55163.1 Torr;
With 1,2,3,4,5-pentafluoro-6-iodosylbenzene; 5,10,15,20-tetra(2',6'-dichlorophenyl)porphyrinatoiron(III) chloride In methanol; dichloromethane; water at 25℃; for 0.05h;

: 108-38-3
m-xylene

A: 576-26-1
2.6-dimethylphenol

B: 105-67-9
2,4-Xylenol

Conditions

Conditions	Yield
Stage #1: m-xylene With spiro[bicyclo[2.2.1]heptane-2,4′-[1,2]dioxolane]-3′,5′-dione at 40℃; for 84h; Sealed tube; Stage #2: With methylamine In ethanol	A 5% B 78%
Stage #1: m-xylene With phthaloyl peroxide Heating; Stage #2: With water; sodium hydrogencarbonate In methanol at 40℃; Overall yield = 94 %;
With perfluorodecanoic acid; cytochrome P450Bm3 KT2 (A191T/N239H/I259V/A276T/L353I); oxygen; NADPH In dimethyl sulfoxide at 30℃; pH=7.4; Reagent/catalyst; Enzymatic reaction;
With C27H19N3O7OsS; dihydrogen peroxide; acetic acid In dichloromethane at 23℃; for 0.416667h; Inert atmosphere; Overall yield = 95 %;

: 100-66-3
methoxybenzene

A: 578-58-5
2-methylmethoxybenzene

B: 108-39-4
3-methyl-phenol

C: 108-88-3
toluene

D: 105-67-9
2,4-Xylenol

E: 71-43-2
benzene

F: 108-95-2
phenol

Conditions

Conditions	Yield
With hydrogen In hexane at 340℃; under 3750.38 Torr; for 3h; Reagent/catalyst;

...Expand

: 5-hydroxy-2,4-dimethyl-2-cyclohexenone

: 105-67-9
2,4-Xylenol

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In benzene at 70℃;	99%
With toluene-4-sulfonic acid In benzene at 70℃;	99%

: 1253261-50-5
2,4-bis(2,4-dimethylphenoxymethyl)allyloxybenzene

: 105-67-9
2,4-Xylenol

Conditions

Conditions	Yield
With sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium(0) In N,N-dimethyl-formamide at 20℃;	89%

: 1253261-52-7
2,4-bis(2,4-bis(2,4-dimethylphenoxymethyl)phenoxymethyl)allyloxybenzene

: 105-67-9
2,4-Xylenol

Conditions

Conditions	Yield
With sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium(0) In N,N-dimethyl-formamide at 20℃;	93%

: 93981-82-9
2,4-dimethyl(allyloxy)benzene

: 105-67-9
2,4-Xylenol

Conditions

Conditions	Yield
With sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium(0) In N,N-dimethyl-formamide at 20℃; for 0.5h;	93%

: 15174-69-3
4-hydroxy-3-methyl-benzaldehyde

: 105-67-9
2,4-Xylenol

Conditions

Conditions	Yield
With formic acid In water at 130℃; for 6h; Green chemistry;
With hydrogen In ethanol at 170℃; under 7500.75 Torr; for 22h; Autoclave;

: 1253261-52-7
2,4-bis(2,4-bis(2,4-dimethylphenoxymethyl)phenoxymethyl)allyloxybenzene

A: 1253261-58-3
C59H64O7

B: 105-67-9
2,4-Xylenol

Conditions

Conditions	Yield
With sodium tetrahydroborate; palladium on carbon In tetrahydrofuran at 20℃;	A n/a B 80%

: C28H44O2P2

: 105-67-9
2,4-Xylenol

Conditions

Conditions	Yield
With chlorobis(ethylene)rhodium(I) dimer; hydrogen In 1,4-dioxane at 150℃; under 2585.81 Torr;	77%

: 1253261-50-5
2,4-bis(2,4-dimethylphenoxymethyl)allyloxybenzene

A: 1253261-56-1
C27H32O3

B: 105-67-9
2,4-Xylenol

Conditions

Conditions	Yield
With sodium tetrahydroborate; palladium on carbon In tetrahydrofuran at 20℃;	A n/a B 70%

: 67-56-1
methanol

: 108-95-2
phenol

A: 106-44-5
p-cresol

B: 576-26-1
2.6-dimethylphenol

C: 108-39-4
3-methyl-phenol

D: 100-66-3
methoxybenzene

E: 95-48-7
ortho-cresol

F: 105-67-9
2,4-Xylenol

Conditions

Conditions	Yield
With zeolite HBEA at 199.84℃; under 759.826 Torr; for 4h; Catalytic behavior; Reagent/catalyst; Inert atmosphere;

...Expand

: 93981-82-9
2,4-dimethyl(allyloxy)benzene

A: 1253261-54-9
2,4-dimethylpropoxybenzene

B: 105-67-9
2,4-Xylenol

Conditions

Conditions	Yield
With sodium tetrahydroborate; palladium on carbon In tetrahydrofuran at 20℃; for 48h;	A n/a B 54%

: 2,4-dimethylphenyl benzylsulfonate

: 105-67-9
2,4-Xylenol

Conditions

Conditions	Yield
With 4,4'-di-tert-butylbiphenyl; lithium In tetrahydrofuran at -50℃; for 0.8h;	73%

: sodium[tetrakis(2,4-dimethylphenyloxy)borate]

: 105-67-9
2,4-Xylenol

Conditions

Conditions	Yield
Stage #1: sodium[tetrakis(2,4-dimethylphenyloxy)borate] In tetrahydrofuran at 20℃; Electrolysis; Stage #2: With citric acid In tetrahydrofuran; water for 0.0833333h;	99%

: 75-16-1
methylmagnesium bromide

: 120-83-2
2,4-dichlorophenol

A: 1570-64-5
2-methyl-4-chlorophenol

B: 105-67-9
2,4-Xylenol

Conditions

Conditions	Yield
With Ni(1,2-bis(diphenylphosphanyl)-benzene)Cl2 In toluene at 0 - 75℃; Inert atmosphere; regioselective reaction;	A 50% B 7%

...Expand

: 4214-28-2
1-iodo-2,4-dimethylbenzene

: 105-67-9
2,4-Xylenol

Conditions

Conditions	Yield
Stage #1: 1-iodo-2,4-dimethylbenzene With copper(l) iodide; 2-methyl-8-quinolinol; tetra(n-butyl)ammonium hydroxide In water; dimethyl sulfoxide at 100℃; for 10h; Stage #2: With hydrogenchloride In water; N,N-dimethyl-formamide at 20℃;	91%

nanocrystalline cellulose: nanocrystalline cellulose

A: 1757-42-2, 6195-92-2
3-methyl-cyclopentanone

B: 106-44-5
p-cresol

C: 95-48-7
ortho-cresol

D: 120-92-3
cyclopentanone

E: 105-67-9
2,4-Xylenol

F: 108-68-9
3,5-Dimethylphenol

G: 108-95-2
phenol

Conditions

Conditions	Yield
With water at 550℃; under 165492 Torr; Supercritical conditions; Flow reactor;

...Expand

nanocrystalline cellulose: nanocrystalline cellulose

A: 1120-72-5
2-Methylcyclopentanone

B: 1757-42-2, 6195-92-2
3-methyl-cyclopentanone

C: 106-44-5
p-cresol

D: 527-60-6
Mesitol

E: 802294-64-0
propionic acid

F: 120-92-3
cyclopentanone

G: 105-67-9
2,4-Xylenol

H: 108-95-2
phenol

Conditions

Conditions	Yield
With water at 500℃; under 165492 Torr; Supercritical conditions; Flow reactor;

...Expand

: 127797-62-0
(2,4-dimethyl-phenyl)-methallyl ether

A: 105-67-9
2,4-Xylenol

B: 2,3-dihydro-2,2,5,7-tetramethylbenzofuran

Conditions

Conditions	Yield
With hexacarbonyl molybdenum In toluene at 115℃; for 55h; Yields of byproduct given;	A n/a B 60%

: 87241-52-9
2,4-dimethylphenyl trifluoromethanesulfonate

A: 108-38-3
m-xylene

B: 105-67-9
2,4-Xylenol

Conditions

Conditions	Yield
With lithium; nickel dichloride In tetrahydrofuran at 20℃; Reduction;	A 58% B 15%

: 6738-23-4
2,4-dimethylanisole

: 105-67-9
2,4-Xylenol

Conditions

Conditions	Yield
With lithium; ethylenediamine In tetrahydrofuran at -10℃; for 5h;	34%
With boron tribromide In dichloromethane at 0℃; for 2h;

: sodium[tetrakis(2,4-dimethylphenyloxy)borate]

A: 26567-10-2
2,2'-dihydroxy-3,3',5,5'-tetramethylbiphenyl

B: 105-67-9
2,4-Xylenol

Conditions

Conditions	Yield
Stage #1: sodium[tetrakis(2,4-dimethylphenyloxy)borate] In N,N-dimethyl-formamide at 20℃; Electrolysis; Stage #2: With citric acid In water; N,N-dimethyl-formamide for 0.0833333h;	A 2% B 65%
Stage #1: sodium[tetrakis(2,4-dimethylphenyloxy)borate] In acetonitrile at 40℃; Electrolysis; Stage #2: With citric acid In water; acetonitrile for 0.0833333h;	A 63 % Chromat. B 28 % Chromat.

: 1260760-32-4
(E)-1-(4,4-dimethylpent-2-enyloxy)-2,4-dimethylbenzene

A: 1260760-80-2
(E)-2-(4,4-dimethylpent-2-enyl)-4,6-dimethylphenol

B: 105-67-9
2,4-Xylenol

Conditions

Conditions	Yield
With triphenylphosphine gold (I) chloride; silver trifluoromethanesulfonate In 1,2-dichloro-ethane at 20℃; for 65h; Claisen type rearrangement; Inert atmosphere;	A 56% B 31%

nanocrystalline cellulose: nanocrystalline cellulose

A: 1120-72-5
2-Methylcyclopentanone

B: 1757-42-2, 6195-92-2
3-methyl-cyclopentanone

C: 106-44-5
p-cresol

D: 589-38-8
n-hexan-3-one

E: 95-48-7
ortho-cresol

F: 120-92-3
cyclopentanone

G: 105-67-9
2,4-Xylenol

H: 108-68-9
3,5-Dimethylphenol

I: 108-95-2
phenol

Conditions

Conditions	Yield
With water at 525℃; under 165492 Torr; Supercritical conditions; Flow reactor;

...Expand

: 83208-06-4
2-[2.4]xylyl-propanol-(2)

: 105-67-9
2,4-Xylenol

Conditions

Conditions	Yield
With sodium perborate; boron trifluoride diethyl etherate In tetrahydrofuran 1.) 0 deg C, 30 min; 2.) 50 deg C, 1 h;	73%

: 98-11-3
benzenesulfonic acid

: 105-67-9
2,4-Xylenol

Conditions

Conditions	Yield
With toluene-4-sulfonic acid

: 121-33-5
vanillin

A: 93-51-6
2-Methoxy-4-methylphenol

B: 90-05-1
2-methoxy-phenol

C: 105-67-9
2,4-Xylenol

Conditions

Conditions	Yield
With hydrogen In decalin at 120℃; under 15001.5 Torr; for 2h;

...Expand

: 105-67-9
2,4-Xylenol

: 74-88-4
methyl iodide

: 6738-23-4
2,4-dimethylanisole

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide at 20℃; for 5h; Methylation;	100%
With potassium carbonate In N,N-dimethyl-formamide at 20℃; Cooling with ice;	85%
With potassium carbonate In water; N,N-dimethyl-formamide at 20℃; Cooling with ice;	85%

: 96-32-2
bromoacetic acid methyl ester

: 105-67-9
2,4-Xylenol

: 95450-79-6
(2,4-Dimethyl-phenoxy)-acetic acid methyl ester

Conditions

Conditions	Yield
With potassium carbonate In butanone for 5.5h; Heating;	100%

: 485-47-2
indan-1,2,3-trione hydrate

: 105-67-9
2,4-Xylenol

: 71321-32-9
2-Hydroxy-2-(2-hydroxy-3,5-dimethyl-phenyl)-indan-1,3-dione

Conditions

Conditions	Yield
In acetic acid for 0.5h; Heating;	100%

: 110-91-8
morpholine

: 50-00-0
formaldehyd

: 105-67-9
2,4-Xylenol

: 97032-14-9
2,4-dimethyl-6-morpholin-4-ylmethyl-phenol

Conditions

Conditions	Yield
With aluminum oxide Mannich type reaction, aminomethylation; Irradiation; microwave;	100%

...Expand

: 105-67-9
2,4-Xylenol

: 20340-62-9
tris(2,4-dimethylphenoxy)borone

Conditions

Conditions	Yield
With boric acid In toluene for 12h; Heating;	100%

: 100-39-0
benzyl bromide

: 105-67-9
2,4-Xylenol

: 19578-72-4
1-(benzyloxy)-2,4-dimethylbenzene

Conditions

Conditions	Yield
With potassium carbonate In acetone for 12h; Reflux; Sealed tube;	100%
With potassium phosphate; tetrabutylammomium bromide In water at 20℃; for 2h; Sealed tube; Green chemistry;	99%

: 50-00-0
formaldehyd

: 124-40-3
dimethyl amine

: 105-67-9
2,4-Xylenol

: 52777-93-2
2-(N,N-dimethylaminomethyl)-4,6-dimethylophenol

Conditions

Conditions	Yield
In ethanol for 48h; Inert atmosphere; Schlenk technique; Reflux;	99%
In water at 0 - 100℃; for 2.5h; Mannich Aminomethylation;	78%

...Expand

: 108-24-7
acetic anhydride

: 105-67-9
2,4-Xylenol

: 877-53-2
2,4-dimethylphenyl acetate

Conditions

Conditions	Yield
With 4-(dimethylamino)pyridine hydrochloride In toluene at 60℃; for 8h;	99%
With rice husk ash at 80℃; for 0.2h; Green chemistry;	97%
With Cu(2+)Zr(4+)2PO4(3-) = CuZr(PO4)2 at 60℃; for 0.333333h;	95%

: 102-92-1
Cinnamoyl chloride

: 105-67-9
2,4-Xylenol

: 99430-00-9
2,4-dimethylphenyl trans-cinnamate

Conditions

Conditions	Yield
With pyridine In benzene for 1h; Heating;	99%
With magnesium In benzene for 2h; Heating;	69%

: 2179-51-3
4-(2,6-di-tert-butyl-4-methylphenoxy)-2,6-di-tert-butyl-4-methyl-2,5-cyclohexadien-1-one

: 105-67-9
2,4-Xylenol

A: 1516-94-5
1,2-bis(3,5-di-tert-butyl-4-hydroxyphenyl)ethane

B: 128-37-0
2,6-di-tert-butyl-4-methyl-phenol

C: 131544-07-5
2,6-di-tert-butyl-4-(3,5-dimethyl-2-hydroxyphenyl)-4-methylcyclohexa-2,5-dien-1-one

D: 131544-12-2
3,5-di-tert-butyl-4-hydroxybenzyl 2,4-dimethylphenyl ether

Conditions

Conditions	Yield
In triethylamine	A 3.9% B 99% C 54% D 17%

...Expand

: 762-42-5
dimethyl acetylenedicarboxylate

: 105-67-9
2,4-Xylenol

: C14H16O5

Conditions

Conditions	Yield
With 1,4-diaza-bicyclo[2.2.2]octane In dichloromethane at 20℃; for 0.166667h;	99%

: 124-63-0
methanesulfonyl chloride

: 105-67-9
2,4-Xylenol

: 723755-74-6
2,4-dimethylphenyl methanesulfonate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 1h;	99%
With triethylamine In dichloromethane

: 139139-80-3
bis(2,4,6-trimethylphenyl)iodonium triflate

: 105-67-9
2,4-Xylenol

: 1268694-21-8
2,4-dimethylphenyl(2,4,6-trimethylphenyl) ether

Conditions

Conditions	Yield
Stage #1: 2,4-Xylenol With potassium tert-butylate In tetrahydrofuran at 0℃; for 0.25h; Stage #2: bis(2,4,6-trimethylphenyl)iodonium triflate In tetrahydrofuran at 40℃; for 0.25h;	99%
Stage #1: 2,4-Xylenol With potassium tert-butylate In tetrahydrofuran at 0℃; for 0.25h; Stage #2: bis(2,4,6-trimethylphenyl)iodonium triflate In tetrahydrofuran at 40℃; for 0.25h;	99%

: 546-68-9
titanium(IV) isopropylate

: 105-67-9
2,4-Xylenol

: 1394844-93-9
[(2,4-dimethylphenoxy)2Ti(isopropoxy)2]

Conditions

Conditions	Yield
In cyclohexane at 20℃; Inert atmosphere; Schlenk technique;	99%

: 98-98-6
2-Picolinic acid

: 105-67-9
2,4-Xylenol

: 2,4-dimethylphenyl picolinate

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; Inert atmosphere;	99%

: 542-69-8
1-iodo-butane

: 201230-82-2
carbon monoxide

: 105-67-9
2,4-Xylenol

: 723757-89-9
C13H18O2

Conditions

Conditions	Yield
With rhodium(III) chloride; 1,3-bis-(diphenylphosphino)propane; sodium carbonate; sodium bromide In 1,4-dioxane at 120℃; under 750.075 Torr; for 24h; Inert atmosphere; chemoselective reaction;	99%

...Expand

: 105-67-9
2,4-Xylenol

: 15191-36-3
2-bromo-4,6-dimethylphenol

Conditions

Conditions	Yield
With trans-3,5-dihydroperoxy-3,5-dimethyl-1,2-dioxolane; hydrogen bromide In water at 20℃; for 1.4h;	98%
With trans-3,5-dihydroperoxy-3,5-dimethyl-1,2-dioxolane; ammonium bromide; acetic acid at 20℃; for 2h; regioselective reaction;	98%
With benzyltriphenylphosphonium tribromide; calcium carbonate In methanol; dichloromethane at 20℃; for 0.5h;	94%

: 64-19-7
acetic acid

: 105-67-9
2,4-Xylenol

: 1198-66-9
3,5-dimethyl-2-hydroxyacetophenone

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate for 0.0333333h; microwave irradiation;	98%
With iron(III) chloride for 0.0166667h; Friedel Crafts acylation; Microwave irradiation; regioselective reaction;	60%
With boron trifluoride diethyl etherate

: 50-00-0
formaldehyd

: 123-12-6
N,N,N',N'-tetraethyldiethylenetriamine

: 105-67-9
2,4-Xylenol

: 620598-29-0
2,4-dimethyl-6-bis(2-(diethylamino)-ethyl)aminomethyl phenol

Conditions

Conditions	Yield
Stage #1: formaldehyd; N,N,N',N'-tetraethyldiethylenetriamine at 80℃; for 2h; Stage #2: 2,4-Xylenol In methanol for 24h; Heating;	98%
Stage #1: formaldehyd; N,N,N',N'-tetraethyldiethylenetriamine at 80℃; for 1h; Stage #2: 2,4-Xylenol In methanol for 24h; Heating;	70%

...Expand

: 75-36-5
acetyl chloride

: 105-67-9
2,4-Xylenol

: 877-53-2
2,4-dimethylphenyl acetate

Conditions

Conditions	Yield
With pyridine In dichloromethane; water	98%
With Fe/SWCNTs at 20℃; for 0.2h;	95%
With pyridine In dichloromethane at 0 - 20℃; for 5h;

: 50-00-0
formaldehyd

: 16215-21-7
butyl 3-mercaptopropionate

: 105-67-9
2,4-Xylenol

: 1192176-12-7
butyl 3-(2-hydroxy-3,5-dimethylbenzylsulfanyl)propionate

Conditions

Conditions	Yield
With dimethyl amine In ethanol; N,N-dimethyl-formamide for 2h; Inert atmosphere; Reflux;	98%
With dimethyl amine In ethanol; N,N-dimethyl-formamide for 2h; Reflux; Inert atmosphere;

...Expand

: 4187-87-5
1-Phenyl-2-propyn-1-ol

: 105-67-9
2,4-Xylenol

: 1214890-86-4
2,4-dimethyl-6-(1-phenylprop-2-ynyl)phenol

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate In dichloromethane at 20℃; Inert atmosphere;	98%

: 105-67-9
2,4-Xylenol

: 4-(2-oxoimidazolidin-1-yl)benzene-1-sulfonyl chloride

: 1311945-66-0
2,4-dimethylphenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 25℃; for 24h; Inert atmosphere;	98%

: 104-88-1
4-chlorobenzaldehyde

: 105-67-9
2,4-Xylenol

: 6,6'-((4-chlorophenyl)methylene)bis(2,4-dimethylphenol)

Conditions

Conditions	Yield
With sulfonated reduced graphene oxide nanosheets In water for 0.1h; Catalytic behavior; Microwave irradiation;	98%
With sulfonatedreduced graphene oxide nanosheet In neat (no solvent) at 100℃; for 0.5h; Catalytic behavior; Green chemistry;	90%
With toluene-4-sulfonic acid In neat (no solvent) at 100℃; for 0.833333h;	81%

: 1122-91-4
4-bromo-benzaldehyde

: 105-67-9
2,4-Xylenol

: 6,6'-((4-bromophenyl)methylene)bis(2,4-dimethylphenol)

Conditions

Conditions	Yield
With sulfonated reduced graphene oxide nanosheets In water for 0.0833333h; Catalytic behavior; Microwave irradiation;	98%
With sulfonatedreduced graphene oxide nanosheet In neat (no solvent) at 100℃; for 0.333333h; Catalytic behavior; Green chemistry;	95%

: 105-67-9
2,4-Xylenol

: 2451-62-9
teroxirone

: 1665-48-1
metaxalone

Conditions

Conditions	Yield
With potassium hydroxide; 4-methyl-2-pentanone at 0 - 120℃; for 3 - 4h;	97%

: 999-97-3
1,1,1,3,3,3-hexamethyl-disilazane

: 105-67-9
2,4-Xylenol

: 16414-81-6
1,3-dimethyl-4-trimethylsilyloxybenzene

Conditions

Conditions	Yield
With 1,3-disulfonic acid imidazolium hydrogen sulfate In neat (no solvent) at 20℃; for 0.0166667h; Green chemistry;	97%
With poly(4-vinylpyridine) In acetonitrile at 20℃; for 0.333333h;	97%
With 3-methyl-1-sulfonic acid imidazolium hydrogen sulfate at 20℃; for 0.0166667h; Neat (no solvent);	96%

: 93-97-0
benzoic acid anhydride

: 105-67-9
2,4-Xylenol

: 76048-43-6
2,4-dimethylphenyl benzoate

Conditions

Conditions	Yield
With 4-(dimethylamino)pyridine hydrochloride In toluene at 60℃; for 10h;	97%

2,4-Dimethylphenol Chemical Properties

IUPAC Name: 2,4-Dimethylphenol
Molecular Formula: C₈H₁₀O
Molecular Weight: 122.17 g/mol
Canonical SMILES: c1(c(ccc(c1)C)O)C
InChI: InChI=1/C8H10O/c1-6-3-4-8(9)7(2)5-6/h3-5,9H,1-2H3
EINECS: 203-321-6
Classification Code: Agricultural Chemical; Drug / Therapeutic Agent; Germicide, bactericide, disinfectant; Tumor data
Product Categories: Aromatic Phenols; Alpha Sort; D; DAlphabetic; DID - DIN; Volatiles / Semivolatiles
Surface Tension: 37.2 dyne/cm
Density: 1.014 g/cm³
Flash Point: 85.6 °C
Enthalpy of Vaporization: 46.55 kJ/mol
Boiling Point: 210.9 °C at 760 mmHg
Melting Point: 22-23 °C(lit.)
Storage temperature: 2-8 °C
Water Solubility: 0.5 g/100 mL (25 °C)
Vapour Pressure of 2,4-Dimethylphenol (CAS NO.105-67-9): 0.129 mmHg at 25 °C

2,4-Dimethylphenol Uses

2,4-Dimethylphenol (CAS NO.105-67-9) is used for organic synthesis and manufacture of pharmaceuticals, plastics, insecticides, fungicides, rubber chem, wetting agents, dyestuffs.

2,4-Dimethylphenol Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	183mg/kg (183mg/kg)		Journal of Medicinal Chemistry. Vol. 18, Pg. 868, 1975.
mouse	LD50	intravenous	100mg/kg (100mg/kg)	BEHAVIORAL: SLEEP	Journal of Medicinal Chemistry. Vol. 23, Pg. 1350, 1980.
mouse	LD50	oral	809mg/kg (809mg/kg)		Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 18(2), Pg. 58, 1974.
rat	LC	inhalation	> 30mg/m3 (30mg/m3)		Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 23(10), Pg. 52, 1979.
rat	LD50	oral	3200mg/kg (3200mg/kg)		Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 18(2), Pg. 58, 1974.
rat	LD50	skin	1040mg/kg (1040mg/kg)		Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 18(2), Pg. 58, 1974.

2,4-Dimethylphenol Consensus Reports

Reported in EPA TSCA Inventory.

2,4-Dimethylphenol Safety Profile

Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion and skin contact. Questionable carcinogen with experimental carcinogenic data. When heated to decomposition it emits acrid smoke and irritating fumes.
Hazard Codes: Toxic T, Dangerous N, Flammable F
Risk Statements: 24/25-34-51/53-39/23/24/25-23/24/25-11
R24/25: Toxic in contact with skin and if swallowed
R34: Causes burns.
R51/53: Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
R39/23/24/25: Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed.
R23/24/25: Toxic by inhalation, in contact with skin and if swallowed.
R11: Highly flammable.
Safety Statements: 26-36/37/39-45-61-36/37-16-7
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S61: Avoid release to the environment. Refer to special instructions / safety data sheets.
S36/37: Wear suitable protective clothing and gloves.
S16: Keep away from sources of ignition.
S7: Keep container tightly closed.
RIDADR: UN 2261 6.1/PG 2
WGK Germany: 3
RTECS: ZE5600000
HazardClass: 6.1
PackingGroup of 2,4-Dimethylphenol (CAS NO.105-67-9): II

2,4-Dimethylphenol Specification

2,4-Dimethylphenol (CAS NO.105-67-9), its Synonyms are 2,4-Dimethylphenol ; 1-Hydroxy-2,4-dimethylbenzene ; 4,6-Dimethylphenol ; 4-Hydroxy-1,3-dimethylbenzene ; Bacticin ; Benzene, 2,4-dimethyl-1-hydroxy- ; Bulk Lysol Brand Disinfectant ; Lysol Brand disinfectant ; Phenol, 2,4-dimethyl- . It is clear colorless to yellow liquid.

Product Name

2,4-Xylenol

Synthetic route

2,4-Dimethylphenol Chemical Properties

2,4-Dimethylphenol Uses

2,4-Dimethylphenol Toxicity Data With Reference

2,4-Dimethylphenol Consensus Reports

2,4-Dimethylphenol Safety Profile

2,4-Dimethylphenol Specification

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