2',5'-Dihydroxyacetophenone supplier

Name
2',5'-Dihydroxyacetophenone
EINECS 207-716-4
CAS No. 490-78-8
Article Data89
CAS DataBase
Density 1.291 g/cm³
Solubility insoluble in water
Melting Point 204-206 °C(lit.)
Formula C₈H₈O₃
Boiling Point 329.2 °C at 760 mmHg
Molecular Weight 152.15
Flash Point 167.1 °C
Transport Information
Appearance yellow to yellow-green crystals
Safety 26-36
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms 3,5-Dihydroxy acetophenone;2,5-dihydroxyacetophenone;Acetophenone,2',5'-dihydroxy- (7CI,8CI);1-(2,5-Dihydroxyphenyl)ethanone;1-Acetyl-2,5-dihydroxybenzene;2,5-Dihydroxy-1-acetylbenzene;2-Acetyl-1,4-benzenediol;2-Acetylhydroquinone;NSC 3759;Quinacetophenone;
PSA 57.53000
LogP 1.30040

Synthetic route

: 64-19-7
acetic acid

: 123-31-9
hydroquinone

: 490-78-8
2,5-Dihydroxyacetophenone

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate for 0.0333333h; microwave irradiation;	98%
With iron(III) chloride for 0.0166667h; Friedel Crafts acylation; Microwave irradiation; regioselective reaction;	98%
With aluminum oxide; methanesulfonic acid at 120℃; for 0.333333h;	85%

: 108-24-7
acetic anhydride

: 123-31-9
hydroquinone

: 490-78-8
2,5-Dihydroxyacetophenone

Conditions

Conditions	Yield
Stage #1: acetic anhydride; hydroquinone In 1,2-dichloro-ethane at 100℃; for 4h; Friedel-Crafts Acylation; Stage #2: With boron trifluoride diethyl etherate In 1,2-dichloro-ethane at 120℃; for 3h;	92%
zinc(II) chloride at 145 - 150℃; for 0.25h;	76%

: 127-17-3
2-oxo-propionic acid

: 106-51-4
p-benzoquinone

: 490-78-8
2,5-Dihydroxyacetophenone

Conditions

Conditions	Yield
With ammonium persulfate; silver nitrate In water; acetonitrile at 70℃; for 2h;	92%

: 1205-91-0
benzene-1,4-diyl diacetate

: 490-78-8
2,5-Dihydroxyacetophenone

Conditions

Conditions	Yield
for 0.116667h; Rearrangement; microwave irradiation;	90%
Stage #1: benzene-1,4-diyl diacetate With aluminum (III) chloride; sodium chloride at 140 - 195℃; for 0.15h; Stage #2: With hydrogenchloride; water for 0.5h; Reflux;	85%
Stage #1: benzene-1,4-diyl diacetate With aluminum (III) chloride; sodium chloride at 180℃; for 3h; Fries rearrangement; Stage #2: With hydrogenchloride In methanol Reflux;	76.6%

: 40815-75-6
1-(5-allyloxy-2-hydroxyphenyl)-1-ethanone

: 490-78-8
2,5-Dihydroxyacetophenone

Conditions

Conditions	Yield
With bis(benzonitrile)palladium(II) dichloride In benzene for 20h; Heating;	89%

: 111-43-3
Dipropyl ether

: 1205-91-0
benzene-1,4-diyl diacetate

A: 490-78-8
2,5-Dihydroxyacetophenone

B: 288074-68-0
2-hydroxy-5-propoxyacetophenone

Conditions

Conditions	Yield
With boron trifluoride for 1h; Fries rearrangement; Heating;	A 89% B 9%

...Expand

: 705-15-7
1-(2-hydroxy-5-methoxyphenyl)ethan-1-one

: 490-78-8
2,5-Dihydroxyacetophenone

Conditions

Conditions	Yield
With pyridinium p-toluenesulfonate for 0.025h; microwave irradiation;	85%

: 67919-45-3
(+)-euryfuran

: 1125-55-9
2-Acetyl-1,4-benzoquinone

A: 490-78-8
2,5-Dihydroxyacetophenone

B: 2-acetyl-3-(6',6',9'a-trimethyl-4',5',5'aS,6',7',8',9',9'aS-octahydronaphtho[1,2-c]furan-3'-yl)-1,4-benzoquinone

C: 3,6-dihydroxy-2-(6',6',9'a-trimethyl-4',5',5'aS,6',7',8',9',9'aS-octahydronaphtho[1,2-c]furan-3'-yl)-acetophenone

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 5h; Michael reaction;	A n/a B 80% C 17%
In dichloromethane at 20℃; for 5h; Arylation;	A n/a B 51% C 17%

...Expand

: 1125-55-9
2-Acetyl-1,4-benzoquinone

: 55562-82-8
trimethyl(2-methyl-2-propenyl)stannane

A: 490-78-8
2,5-Dihydroxyacetophenone

B: 2-acetyl-3-(2-methylallyl)-1,4-benzenediol

Conditions

Conditions	Yield
In benzene	A 6% B 77%

...Expand

: 1201-38-3
2',5'-dimethoxyacetophenone

: 490-78-8
2,5-Dihydroxyacetophenone

Conditions

Conditions	Yield
With boron dimethyl-trifluoro sulphide In dichloromethane at 20℃; for 1.5h;	74%
With carbon disulfide; aluminum tri-bromide
With pyridine hydrochloride

: 1200-06-2
4-methoxyphenyl acetate

: 490-78-8
2,5-Dihydroxyacetophenone

Conditions

Conditions	Yield
With aluminium trichloride at 140℃; for 2h; Fries rearrangement;	71%
Fries rearrangement;

: 75-36-5
acetyl chloride

: 123-31-9
hydroquinone

: 490-78-8
2,5-Dihydroxyacetophenone

Conditions

Conditions	Yield
With zinc at 47 - 48℃; for 0.0166667h; Friedel-Crafts acylation; microwave irradiation;	70%
With aluminium trichloride; nitrobenzene

: 123-31-9
hydroquinone

: 122-79-2
Phenyl acetate

: 490-78-8
2,5-Dihydroxyacetophenone

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate In benzene for 3h; crossover Friess rearrangement; Heating;	65%

: 79950-56-4
5'-cinnamyloxy-2'-hydroxyacetophenone

: 490-78-8
2,5-Dihydroxyacetophenone

Conditions

Conditions	Yield
at 220℃; for 20h;	64%

: 1201-38-3
2',5'-dimethoxyacetophenone

A: 705-15-7
1-(2-hydroxy-5-methoxyphenyl)ethan-1-one

B: 490-78-8
2,5-Dihydroxyacetophenone

Conditions

Conditions	Yield
With boron dimethyl-trifluoro sulphide In dichloromethane at 0℃; for 0.166667h;	A 64% B 27%

: 1125-55-9
2-Acetyl-1,4-benzoquinone

A: 68157-88-0
2-Acetyl-3-(3-acetyl-4-hydroxyphenoxy)-1,4-benzoquinone

B: 490-78-8
2,5-Dihydroxyacetophenone

Conditions

Conditions	Yield
With rose bengal In acetonitrile for 8h; Irradiation; Yields of byproduct given;	A 60% B n/a

: 1205-91-0
benzene-1,4-diyl diacetate

: 108-95-2
phenol

A: 118-93-4
o-hydroxyacetophenone

B: 490-78-8
2,5-Dihydroxyacetophenone

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate In benzene for 0.5h; cross Fries reaction; microwave irradiation;	A 25% B 60%

...Expand

: 1125-55-9
2-Acetyl-1,4-benzoquinone

A: 19278-82-1
5-hydroxy-2,3-dihydrobenzofuran-3-one

B: 490-78-8
2,5-Dihydroxyacetophenone

Conditions

Conditions	Yield
In benzene for 72h; Irradiation;	A 50% B 45%
In benzene for 72h; Mechanism; Irradiation;	A 50% B 45%

: 90-15-3
α-naphthol

: 1205-91-0
benzene-1,4-diyl diacetate

A: 711-79-5
1-hydroxy-2-acetonaphthone

B: 490-78-8
2,5-Dihydroxyacetophenone

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate In benzene for 0.5h; cross Fries reaction; microwave irradiation;	A 20% B 50%

...Expand

: 1205-91-0
benzene-1,4-diyl diacetate

: 135-19-3
β-naphthol

A: 574-19-6
1-(2-hydroxy-1-naphthyl)ethan-1-one

B: 490-78-8
2,5-Dihydroxyacetophenone

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate In benzene for 0.5h; cross Fries reaction; microwave irradiation;	A 35% B 45%

...Expand

: 108-73-6
3,5-dihydroxyphenol

: 1205-91-0
benzene-1,4-diyl diacetate

A: 480-66-0
2,4,6-trihydroxyacetophenone

B: 490-78-8
2,5-Dihydroxyacetophenone

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate In benzene for 0.5h; cross Fries reaction; microwave irradiation;	A 35% B 40%

...Expand

: 1125-55-9
2-Acetyl-1,4-benzoquinone

: 762-73-2
trimethyl(allyl)stannane

A: 40815-79-0
2-acetyl-3-prop-2'-enyl-1,4-hydroquinone

B: 490-78-8
2,5-Dihydroxyacetophenone

C: 3a-acetyl-2-trimethylstannyl-2,3,3a,4,7,7a-hexahydrindene-4,7-dione

Conditions

Conditions	Yield
In benzene for 5h;	A 27% B 36% C 23%
In benzene dissolved acylquinone and allylstannane stood for 5 h under Ar; concd.; column chromy. (silica gel); eluted (hexane/ether); NMR; IR; mass spectra; elem. anal.;	A 27% B 36% C 23%

...Expand

: 1205-91-0
benzene-1,4-diyl diacetate

A: 20129-52-6
1,4-diacetyl-2,5-dihydroxybenzene

B: 21222-04-8
5'-Acetoxy-2'-hydroxyacetophenone

C: 490-78-8
2,5-Dihydroxyacetophenone

Conditions

Conditions	Yield
In methanol for 12h; Irradiation;	A 10% B 15% C 35%

...Expand

: 98-86-2
acetophenone

A: 121-71-1
3-Hydroxyacetophenone

B: 85918-30-5
2,3,6-trihydroxyacetophenone

C: 490-78-8
2,5-Dihydroxyacetophenone

Conditions

Conditions	Yield
With dihydrogen peroxide; hydrogen fluoride; antimony pentafluoride at -35℃; for 0.5h; Mechanism; Product distribution;	A 31% B 4% C 18%
With dihydrogen peroxide; hydrogen fluoride; antimony pentafluoride at -35℃; for 0.5h;	A 31% B 4% C 18%

...Expand

: 75925-74-5, 94842-18-9
4a,8a-cis-4a-acetyl-4a,5,8,8a-tetrahydro-5,8-methano-1,4-naphthoquinone

: 490-78-8
2,5-Dihydroxyacetophenone

Conditions

Conditions	Yield
With pyridine In xylene Heating;	29%

: (1R,4S)-4a-Acetyl-1,4,4a,8a-tetrahydro-1,4-methano-naphthalene-5,8-dione

: 490-78-8
2,5-Dihydroxyacetophenone

Conditions

Conditions	Yield
In pyridine; xylene at 120℃; for 3h;	29%

: 1125-55-9
2-Acetyl-1,4-benzoquinone

: 24850-33-7
allyltributylstanane

A: 40815-79-0
2-acetyl-3-prop-2'-enyl-1,4-hydroquinone

B: 490-78-8
2,5-Dihydroxyacetophenone

C: 3a-acetyl-2-tributylstannyl-2,3,3a,4,7,7a-hexahydrindene-4,7-dione

Conditions

Conditions	Yield
In benzene for 1.5h;	A 29% B 10% C 10%
In benzene dissolved acylquinone and allylstannane stood for 1.5 h under Ar; concd.; column chromy. (silica gel); eluted (hexane/ether); NMR; IR; mass spectra; elem. anal.;	A 29% B 10% C 10%

...Expand

: 874-23-7
2-acetylcyclohexanone

: 490-78-8
2,5-Dihydroxyacetophenone

Conditions

Conditions	Yield
With (Z/E)-2-bromo-2-[4-oxothiazolidin-2-ylidene]-N-phenylacetamide; dimethyl sulfoxide for 3h; Reflux;	19%

: 1125-55-9
2-Acetyl-1,4-benzoquinone

: 762-73-2
trimethyl(allyl)stannane

A: 40815-79-0
2-acetyl-3-prop-2'-enyl-1,4-hydroquinone

B: 490-78-8
2,5-Dihydroxyacetophenone

Conditions

Conditions	Yield
In acetonitrile dissolved acylquinone and allylstannane stood for 10 min under Ar; concentrated; column chromy. (silica gel); eluted (hexane/ether); NMR; IR; mass spectra; elem. anal.;	A 18% B 18%

...Expand

: 1205-91-0
benzene-1,4-diyl diacetate

A: 21222-04-8
5'-Acetoxy-2'-hydroxyacetophenone

B: 490-78-8
2,5-Dihydroxyacetophenone

Conditions

Conditions	Yield
With aluminium trichloride at 190 - 200℃;
Stage #1: benzene-1,4-diyl diacetate With aluminium trichloride; sodium chloride at 195℃; for 0.15h; Fries rearrangement; Stage #2: With hydrogenchloride In water for 12h; Further stages. Title compound not separated from byproducts.;
Stage #1: benzene-1,4-diyl diacetate With aluminum (III) chloride; sodium chloride at 140 - 195℃; for 0.15h; Stage #2: With hydrogenchloride; water

: 76200-27-6
ethyl (E)-4-methyl-3,5-hexadienoate

: 490-78-8
2,5-Dihydroxyacetophenone

: 72826-95-0, 80866-98-4
(4aR,5R,8aS)-4a-Acetyl-5-(2-benzyloxy-ethyl)-6-methyl-4a,5,8,8a-tetrahydro-[1,4]naphthoquinone

Conditions

Conditions	Yield
With silver(l) oxide Ambient temperature; Absence of light;	100%

: 134637-25-5
C13H18O4

: 490-78-8
2,5-Dihydroxyacetophenone

: 134637-35-7
C21H24O7

Conditions

Conditions	Yield
With silver(l) oxide Ambient temperature;	100%

: 134637-27-7
C14H20O4

: 490-78-8
2,5-Dihydroxyacetophenone

: 134637-38-0
C22H26O7

Conditions

Conditions	Yield
With silver(l) oxide Ambient temperature;	100%

: 134685-78-2
C15H20O5

: 490-78-8
2,5-Dihydroxyacetophenone

: 134637-30-2
C23H26O8

Conditions

Conditions	Yield
With silver(l) oxide for 72h; Ambient temperature;	100%

: 134637-20-0
C16H22O5

: 490-78-8
2,5-Dihydroxyacetophenone

: 134637-32-4
C24H28O8

Conditions

Conditions	Yield
With silver(l) oxide for 168h; Ambient temperature;	100%

: 110-87-2
3,4-dihydro-2H-pyran

: 490-78-8
2,5-Dihydroxyacetophenone

: 3557-22-0
1-(2-hydroxy-5-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)ethan-1-one

Conditions

Conditions	Yield
With pyridinium p-toluenesulfonate In dichloromethane at 20℃;	99%
With pyridinium p-toluenesulfonate In dichloromethane at 20℃; for 4h;	91%
With pyridinium p-toluenesulfonate In dichloromethane at 20℃; for 5h;	87%

: 100-39-0
benzyl bromide

: 490-78-8
2,5-Dihydroxyacetophenone

: 21766-81-4
1-[2',5'-bis(phenylmethoxy)phenyl]ethanone

Conditions

Conditions	Yield
With potassium carbonate In acetone for 18h; Etherification; Heating;	99%
With potassium carbonate In acetone for 24h; Reflux;	94%
Stage #1: 2,5-Dihydroxyacetophenone In 1,2-dimethoxyethane at 80℃; Inert atmosphere; Stage #2: benzyl bromide In 1,2-dimethoxyethane; N,N-dimethyl-formamide for 12h;	93%

: 2033-24-1
cycl-isopropylidene malonate

: 490-78-8
2,5-Dihydroxyacetophenone

: 6-hydroxy-4-methyl-2-oxo-2H-chromene-3-carboxylic acid

Conditions

Conditions	Yield
With kiwi juice In water at 20℃; for 0.0833333h; Reagent/catalyst; Knoevenagel Condensation; Sonication; Green chemistry;	99%
With lithium perchlorate for 0.0194444h; Irradiation;	83%

: 27607-77-8
trimethylsilyl trifluoromethanesulfonate

: 490-78-8
2,5-Dihydroxyacetophenone

: (2-(1-(trimethylsilyloxy)vinyl)-1,4-phenylene)bis(oxy)bis(trimethylsilane)

Conditions

Conditions	Yield
With triethylamine In dichloromethane at -30 - -10℃; for 0.666667h; Inert atmosphere; Sealed tube;	99%

: 79-22-1
methyl chloroformate

: 490-78-8
2,5-Dihydroxyacetophenone

: Carbonic acid 3-acetyl-4-methoxycarbonyloxy-phenyl ester methyl ester

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran 0 deg C to room temp., 0.5 to 1 h;	98%

: 490-78-8
2,5-Dihydroxyacetophenone

: 78-79-5
isoprene

: (4aR,8aS)-4a-Acetyl-7-methyl-4a,5,8,8a-tetrahydro-[1,4]naphthoquinone

Conditions

Conditions	Yield
With lithium perchlorate; acetic acid In nitromethane for 16h; electrolysis;	97%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 490-78-8
2,5-Dihydroxyacetophenone

: 843644-58-6
5'-t-butyldimethylsilyloxy-2'-hydroxyacetophenone

Conditions

Conditions	Yield
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 12h;	97%

: 118-93-4
o-hydroxyacetophenone

: 490-78-8
2,5-Dihydroxyacetophenone

: 849928-22-9
tert-butyl 4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxylate

Conditions

Conditions	Yield
With pyrrolidine In methanol for 24h;	97%

: 106-95-6
allyl bromide

: 490-78-8
2,5-Dihydroxyacetophenone

: 40815-75-6
1-(5-allyloxy-2-hydroxyphenyl)-1-ethanone

Conditions

Conditions	Yield
With potassium carbonate In acetone for 18h; Heating;	96%
With potassium carbonate; sodium iodide In acetone for 15h; Heating;	86%
With potassium carbonate In acetone for 18h; Inert atmosphere; Reflux;	86%

: 490-78-8
2,5-Dihydroxyacetophenone

: 1125-55-9
2-Acetyl-1,4-benzoquinone

Conditions

Conditions	Yield
With manganese(IV) oxide In dichloromethane for 0.25h; Ambient temperature;	95%
With oxygen In chloroform; water at 20℃; under 760.051 Torr; for 6h;	88%
With cerium(IV) ammonium nitrate; silica gel In dichloromethane for 0.25h;	84%

: 100-39-0
benzyl bromide

: 490-78-8
2,5-Dihydroxyacetophenone

: 30992-63-3
5-benzyloxy-2-hydroxyacetophenone

Conditions

Conditions	Yield
With 18-crown-6 ether; potassium carbonate; potassium iodide In toluene at 115℃; for 14h;	95%
With potassium carbonate In acetone for 48h; Reflux;	92%
With sodium hydrogencarbonate In ethanol at 0 - 10℃; for 3.33333h;	88.3%

: 107-21-1
ethylene glycol

: 490-78-8
2,5-Dihydroxyacetophenone

: acetylhydroquinone ethylene acetal

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In benzene for 24h; Heating;	95%

: 1117-52-8
6,10,14-trimethyl-5,9,13-pentadecatriene-2-on

: 490-78-8
2,5-Dihydroxyacetophenone

: 150035-61-3
6-Hydroxy-2-methyl-2-((3E,7E)-4,8,12-trimethyl-trideca-3,7,11-trienyl)-chroman-4-one

Conditions

Conditions	Yield
With pyrrolidine; 3 A molecular sieve In ethanol Heating;	95%

: 3282-30-2
pivaloyl chloride

: 490-78-8
2,5-Dihydroxyacetophenone

: 309721-51-5
2,2-dimethylpropanoic acid 2-acetyl-1,4-phenylene ester

Conditions

Conditions	Yield
With pyridine at 20℃;	95%
With pyridine at 20℃; for 18h;

: 122-51-0
orthoformic acid triethyl ester

: 490-78-8
2,5-Dihydroxyacetophenone

: 38445-24-8
6-hydroxy-4-oxo-4H-1-benzopyran

Conditions

Conditions	Yield
With perchloric acid In water at 20 - 100℃; for 1.08333h;	95%
With perchloric acid at 20℃; for 1.5h;	78%

: 768-95-6
1-adamanthanol

: 490-78-8
2,5-Dihydroxyacetophenone

: 2',5'-dihydroxy-3'-(1-adamantyl)acetophenone

Conditions

Conditions	Yield
With sulfuric acid In dichloromethane at 0℃; Inert atmosphere; Reflux;	94.9%

: 490-78-8
2,5-Dihydroxyacetophenone

: 25015-91-2
2-bromo-1-(2,5-dihydroxyphenyl)ethanone

Conditions

Conditions	Yield
With aluminium trichloride; Montmorillonite K10; bromine In ethyl acetate at 20℃; for 2h;	94%
With urea-hydrogen peroxide; acetic acid; sodium bromide; silica gel at 120 - 122℃; for 0.00611111h; microwave irradiation;	71%
With copper(I) bromide In chloroform; ethyl acetate for 6h; Reflux;	6%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 490-78-8
2,5-Dihydroxyacetophenone

: 1431642-68-0
1-(2,5-bis(tert-butyldimethylsilyloxy)phenyl)ethanone

Conditions

Conditions	Yield
With 1H-imidazole In N,N-dimethyl-formamide at 50℃; for 16h; Inert atmosphere;	93.2%

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 490-78-8
2,5-Dihydroxyacetophenone

: 911227-48-0
tert-butyl 6-hydroxy-4-oxospiro[chroman-2,4′-piperidine]-1′-carboxylate

Conditions

Conditions	Yield
With pyrrolidine In methanol at 60℃; for 48h;	93%
With pyrrolidine In methanol for 18h; Reflux;	87%
With pyrrolidine In methanol for 23h; Reflux;	82%

: 110-93-0
6-Methyl-hept-5-en-2-on

: 490-78-8
2,5-Dihydroxyacetophenone

: 69367-11-9
6-Hydroxy-2-methyl-2-(4-methyl-3-pentenyl)-4-chromanon

Conditions

Conditions	Yield
With pyrrolidine; 3 A molecular sieve In ethanol Heating;	92%

: 490-78-8
2,5-Dihydroxyacetophenone

: 100-46-9
benzylamine

: 82488-61-7
2,5-Dihydroxyphenylethylidenebenzylamine

Conditions

Conditions	Yield
In toluene Heating; or ZnCl2, 1) 30 min, 160 deg C, 2) 5 min, 180 deg C;	92%
In toluene Heating;	90%

: 108-94-1
cyclohexanone

: 490-78-8
2,5-Dihydroxyacetophenone

: 135110-68-8
6-hydroxy-spiro-4-one

Conditions

Conditions	Yield
With piperidine for 0.166667h; Neat (no solvent); Microwave irradiation;	92%
With pyrrolidine In ethanol Reflux;	92%
With Amberlite IRA 400 basic resin for 0.133333h; Microwave irradiation; Neat (no solvent);	86%
With pyrrolidine In isopropyl alcohol for 2h; Mechanism; Heating; other acetophenones;	72%
With pyrrolidine In isopropyl alcohol for 2h; Heating;	72%

2',5'-Dihydroxyacetophenone Chemical Properties

Molecular Formula:C₈H₈O₃
Molar mass:152.14732 g/mol
Structure :

Synonyms of 2',5'-Dihydroxyacetophenone(490-78-8):2-Acetylhydroquinone;Quinacetophenone;2,5-Dihydroxyacetophenone;Acetylquinol;Acetylhydroquinone;Acetophenone, 2',5'-dihydroxy-;Ethanone, 1-(2,5-dihydroxyphenyl)-
Density:1.291 g/cm³
Flash Point:167.1 °C
Boiling Point:329.2 °C at 760 mmHg
Index of Refraction:1.595
Vapour Pressure:9.41E-05 mmHg at 25°C
Melting point:204-206 °C
Water solubility:insoluble
Solubility:dioxane: 50 mg/mL, clear

2',5'-Dihydroxyacetophenone Uses

2',5'-Dihydroxyacetophenone(490-78-8) can be used in organic synthesis.

2',5'-Dihydroxyacetophenone Production

Derived by the reaction of Hydroquinone diacetate at the presence of aluminum chloride.

2',5'-Dihydroxyacetophenone Toxicity Data With Reference

ipr-mus LDLo:500 mg/kg

CBCCT* “Summary Tables of Biological Tests“ National Research Council Chemical-Biological Coordination Center. 5 (1953),140.

Carcinogenicity:2',5'-Dihydroxyacetophenone(490-78-8)- Not listed as a carcinogen by IARC, NTP,ACGIH, or CA Prop 65.
Other: See actual entry in RTECS for complete information.

2',5'-Dihydroxyacetophenone Consensus Reports

Reported in EPA TSCA Inventory.

2',5'-Dihydroxyacetophenone Safety Profile

Moderately toxic by intraperitoneal route. When heated to decomposition it emits acrid smoke and irritating fumes.
Hazard Codes:Xi

Risk Statements:
36: Irritating to the eyes
37: Irritating to the respiratory system
38: Irritating to the skin
Safety Statements:
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing

2',5'-Dihydroxyacetophenone Specification

Stability and Reactivity of 2',5'-Dihydroxyacetophenone(490-78-8):
Conditions to Avoid:strong oxidants,incompatible materials.
Chemical Stability:Stable under normal temperatures and pressures.
Incompatibilities with Other Materials:strong bases,strong oxidizing agents.
Hazardous Decomposition Products:Irritating and toxic fumes and gases,Carbon monoxide.

Product Name

2',5'-Dihydroxyacetophenone

Synthetic route

2',5'-Dihydroxyacetophenone Chemical Properties

2',5'-Dihydroxyacetophenone Uses

2',5'-Dihydroxyacetophenone Production

2',5'-Dihydroxyacetophenone Toxicity Data With Reference

2',5'-Dihydroxyacetophenone Consensus Reports

2',5'-Dihydroxyacetophenone Safety Profile

2',5'-Dihydroxyacetophenone Specification

Related Products

Hot Products