2-Amino-5-chlorobenzophenone supplier

Name
2-Amino-5-chlorobenzophenone
EINECS 211-949-7
CAS No. 719-59-5
Article Data107
CAS DataBase
Density 1.274 g/cm³
Solubility insoluble
Melting Point 96-98 °C(lit.)
Formula C₁₃H₁₀ClNO
Boiling Point 424.3 °C at 760 mmHg
Molecular Weight 231.681
Flash Point 210.4 °C
Transport Information
Appearance yellow powder
Safety 26-36
Risk Codes 36/37/38-22-20/21/22
Molecular Structure
Hazard Symbols Xn， Xi
Synonyms (2-amino-5-chlorophenyl)(phenyl)methanone;Aminoketone;Benzophenone, 2-amino-5-chloro- (8CI);5-Chloro-2-aminobenzophenone;Benzophenone, 2-amino-5-chloro-;(2-amino-5-chloro-phenyl)-phenyl-methanone;(2-Amino-5-chlorophenyl)phenylmethanone;Methanone, (2-amino-5-chlorophenyl)phenyl-;2-Benzoyl-4-chloroaniline;2-Amino-5-chlorobenzylphenone;
PSA 43.09000
LogP 3.73440

Synthetic route

: 719-64-2
5-chloro-3-phenylanthranil

: 719-59-5
2-Amino-5-chlorobenzophenone

Conditions

Conditions	Yield
With trimethylsilyl iodide; water In acetonitrile at 20℃; for 0.2h;	98%
Stage #1: 5-chloro-3-phenylanthranil With iron In ethanol for 0.5h; Reflux; Stage #2: With sulfuric acid In ethanol for 1h; Reflux;	95.1%
With aluminium trichloride; zinc In tetrahydrofuran for 6h; Ambient temperature;	92%

: 5922-60-1
2-amino-5-chlorobenzonitrile

: 98-80-6
phenylboronic acid

: 719-59-5
2-Amino-5-chlorobenzophenone

Conditions

Conditions	Yield
With 5,5'-dimethyl-2,2'-bipyridine; methanesulfonic acid; palladium(II) trifluoroacetate; water In 2-methyltetrahydrofuran at 80℃; for 36h; Schlenk technique;	96%
With [2,2]bipyridinyl; methanesulfonic acid; palladium(II) trifluoroacetate In tetrahydrofuran; water at 80℃; for 36h;

: 2-Amino-5-chlorobenzophenone N,N-dimethylhydrazone

: 719-59-5
2-Amino-5-chlorobenzophenone

Conditions

Conditions	Yield
With triethylene diamine nickel thiosulfate; water In chloroform at 20℃; for 0.166667h; Hydrolysis;	92%

: 5922-60-1
2-amino-5-chlorobenzonitrile

: 873-55-2
sodium benzenesulfonate

: 719-59-5
2-Amino-5-chlorobenzophenone

Conditions

Conditions	Yield
With p-nitrobenzenesulfonic acid; palladium diacetate In tetrahydrofuran; water at 80℃; for 48h; Inert atmosphere; Schlenk technique;	92%

: 55-21-0
benzamide

: 106-47-8
4-chloro-aniline

: 719-59-5
2-Amino-5-chlorobenzophenone

Conditions

Conditions	Yield
Stage #1: benzamide; 4-chloro-aniline With tin(ll) chloride at 123 - 250℃; for 4h; Stage #2: With potassium chloride at 95 - 130℃; for 4h; Stage #3: With phosphoric acid for 23h; Concentration; Temperature; Reflux;	91%

: 105448-12-2
7-Chlor-2-methylthio-5-phenyl-3H-1,3,4-benzotriazepin

A: 74-93-1
methylthiol

B: 719-59-5
2-Amino-5-chlorobenzophenone

Conditions

Conditions	Yield
With hydrogenchloride for 10h;	A n/a B 83.4%

: 106-47-8
4-chloro-aniline

: 100-47-0
benzonitrile

: 719-59-5
2-Amino-5-chlorobenzophenone

Conditions

Conditions	Yield
With gallium(III) trichloride; boron trichloride In chlorobenzene at 100℃; for 20h;	81%
With gallium(III) trichloride; boron trichloride 1.) CH2Cl2, 1,1,2,2-tetrachloroethane, 0 deg C, 2.) 1,1,2,2-tetrachloroethane, 100 deg C, 5 h; Yield given. Multistep reaction;

: 719-64-2
5-chloro-3-phenylanthranil

: 98-80-6
phenylboronic acid

A: 719-59-5
2-Amino-5-chlorobenzophenone

B: 108694-41-3
(5-chloro-2-(phenylamino)phenyl)(phenyl)methanone

Conditions

Conditions	Yield
With potassium carbonate; copper dichloride In dimethyl sulfoxide at 100℃; for 6h; Reagent/catalyst; Solvent; Sealed tube;	A 17% B 81%

...Expand

: 106-47-8
4-chloro-aniline

: 98-88-4
benzoyl chloride

: 719-59-5
2-Amino-5-chlorobenzophenone

Conditions

Conditions	Yield
With antimony(III) oxide In dichloromethane at 15℃; for 2h; Temperature;	78%
Stage #1: 4-chloro-aniline; benzoyl chloride With antimony(III) trioxide In dichloromethane at 15℃; for 2h; Friedel-Crafts Acylation; Stage #2: With nitric acid In dichloromethane at 10 - 45℃; for 11.5h; Temperature;	77%
With dysprosium((III) oxide In tetrachloromethane at 15℃; for 2h; Temperature;	76%

: 86230-82-2
7-chloro-9-phenyl-1,2-dihydrooxazolo<2,3-b>-1,3,4-benzotriazepine

: 719-59-5
2-Amino-5-chlorobenzophenone

Conditions

Conditions	Yield
With sulfuric acid In ethanol at 40℃; for 1.16667h;	75%

: 201230-82-2
carbon monoxide

: 63069-48-7
p-chloro-o-iodoaniline

: 98-80-6
phenylboronic acid

: 719-59-5
2-Amino-5-chlorobenzophenone

Conditions

Conditions	Yield
With potassium carbonate at 100℃; under 2250.23 Torr; for 8h; Catalytic behavior; Suzuki-Miyaura Coupling; Autoclave;	75%

...Expand

: 138964-58-6
5-chloro-2-[(phenylsulfonyl)amino]benzoic acid

: 719-59-5
2-Amino-5-chlorobenzophenone

Conditions

Conditions	Yield
With dipotassium hydrogenphosphate; [4,4’-bis(1,1-dimethylethyl)-2,2’-bipyridine-N1,N1‘]bis [3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-N]phenyl-C]iridium(III) hexafluorophosphate; triphenylphosphine In 1,4-dioxane at 25℃; for 8h; Schlenk technique; Inert atmosphere; Sealed tube; Irradiation;	73%

: 1159372-20-9
(2-amino-5-chlorophenyl)(phenyl)methanol

: 719-59-5
2-Amino-5-chlorobenzophenone

Conditions

Conditions	Yield
With copper(l) iodide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; oxygen; (R)-1,1'-binaphthyl-2,2'-diamine In toluene at 60℃; for 48h;	61%
With 1,4-diaza-bicyclo[2.2.2]octane; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; oxygen; copper(l) chloride In toluene at 100℃; for 24h;	58%
With copper(II) chloride monohydrate; oxygen; potassium carbonate In N,N-dimethyl-formamide at 60℃; for 24h;
With copper(II) chloride monohydrate; potassium carbonate In N,N-dimethyl-formamide at 60℃;
With copper(II) chloride monohydrate; potassium carbonate In N,N-dimethyl-formamide at 60℃; for 24h;

: 23746-76-1
5-chloro-2-phenylindole

: 719-59-5
2-Amino-5-chlorobenzophenone

Conditions

Conditions	Yield
With oxygen; caesium carbonate In dimethyl sulfoxide at 140℃; for 8h;	59%

: 70437-50-2
7-chloro-3-methyl-2-(methyl-thio)-5-phenyl-3H-1,3,4-benzotriazepine

A: 74-93-1
methylthiol

B: 719-59-5
2-Amino-5-chlorobenzophenone

Conditions

Conditions	Yield
With hydrogenchloride for 10h;	A n/a B 57.7%

: 107-10-8
propylamine

: 26381-66-8
5-chloro-2-trichloroacetylaminobenzophenone

A: 719-59-5
2-Amino-5-chlorobenzophenone

B: 37103-80-3
syn-5-chloro-2-trichloroacetamidobenzophenone n-propylimine

C: 80170-54-3
6-chloro-3,4-dihydro-4-phenyl-3-(n-propyl)-4-trichloromethyl-2(1H)-quinazolinone

Conditions

Conditions	Yield
In ethanol at 60℃; for 3h;	A 16% B 57% C 13%

...Expand

: 1159372-20-9
(2-amino-5-chlorophenyl)(phenyl)methanol

: (2-amino-5-chlorophenyl)(phenyl)methanol

: (2-amino-5-chlorophenyl)(phenyl)methanol

C: 719-59-5
2-Amino-5-chlorobenzophenone

Conditions

Conditions	Yield
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; oxygen; copper(II) bis(trifluoromethanesulfonate); (R)-1,1'-binaphthyl-2,2'-diamine In toluene at 60℃; for 24h; optical yield given as %ee;	A n/a B n/a C 57%

...Expand

: 1159372-20-9
(2-amino-5-chlorophenyl)(phenyl)methanol

: (2-amino-5-chlorophenyl)(phenyl)methanol

B: 719-59-5
2-Amino-5-chlorobenzophenone

Conditions

Conditions	Yield
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; oxygen; copper(II) bis(trifluoromethanesulfonate); (R)-1,1'-binaphthyl-2,2'-diamine In toluene at 80℃; for 11h; optical yield given as %ee;	A n/a B 57%

: 26381-66-8
5-chloro-2-trichloroacetylaminobenzophenone

: 141-43-5
ethanolamine

A: 719-59-5
2-Amino-5-chlorobenzophenone

B: 27772-51-6
9-chloro-10b-phenyl-2,3,6,19b-tetrahydro-5H-oxazolo<3,2-c>quinazolin-5-one

C: 80171-01-3
6-chloro-3,4-dihydro-3-(2-hydroxyethyl)-4-phenyl-4-trichloromethyl-2(1H)-quinazolinone

Conditions

Conditions	Yield
In ethanol for 3h; Heating;	A 17% B 43% C 38%

...Expand

: 67863-85-8
3-Amino-6-chlor-4-hydroxy-4-phenyl-2-thioxo-1,2,3,4-tetrahydrochinazolin

: 719-59-5
2-Amino-5-chlorobenzophenone

Conditions

Conditions	Yield
With hydrogenchloride for 10h; Heating;	41.5%
Multi-step reaction with 2 steps 1: 1) CH3ONa, 2) HCl (g) / 1) acetone, 7 d, RT, 2) benzene 2: 5 M HCl / Heating; hydrolysis View Scheme

: 112608-11-4
3-Amino-6-chlor-4-hydroxy-2-methylthio-4-phenyl-3,4-dihydrochinazolinhydrochlorid

A: 74-93-1
methylthiol

B: 719-59-5
2-Amino-5-chlorobenzophenone

C: 112608-09-0
3-Amino-6-chlor-4-hydroxy-2-oxo-4-phenyltetrahydrochinazolin

D: 112608-08-9
N-(2-Benzoyl-4-chlorphenyl)monothiocarbamidsaeure-S-methylester

Conditions

Conditions	Yield
With hydrogenchloride for 0.5h; Heating; reflux;	A n/a B 37% C n/a D n/a
With hydrogenchloride Product distribution; Heating; hydrolysis;

...Expand

: 26381-66-8
5-chloro-2-trichloroacetylaminobenzophenone

: 78-96-6, 1674-56-2
3-amino-2-propanol

A: 719-59-5
2-Amino-5-chlorobenzophenone

B: 80171-03-5
9-chloro-2-methyl-10b-phenyl-2,3,6,10b-tetrahydro-5H-oxazolo<3,2-c>quinazolin-5-one

C: 80171-02-4
6-chloro-3,4-dihydro-3-(2-hydroxypropyl)-4-phenyl-4-trichloromethyl-2(1H)-quinazolinone

Conditions

Conditions	Yield
In propan-1-ol for 8h; Heating;	A 28% B 31% C 36%

...Expand

: 78823-09-3
2'-Benzoyl-4'-chloro-N-(N-phthaloyl-DL-alanyl)sarcosinanilide

A: 719-59-5
2-Amino-5-chlorobenzophenone

B: 78823-10-6
2'-Benzoyl-4'-chloro-N-(DL-alanyl)sarcosinanilide

Conditions

Conditions	Yield
With hydrazine hydrate In ethanol; chloroform for 15h; Ambient temperature;	A 29% B 36%

: 26381-66-8
5-chloro-2-trichloroacetylaminobenzophenone

: 75-31-0
isopropylamine

A: 719-59-5
2-Amino-5-chlorobenzophenone

B: 70547-52-3
1-(2-benzoyl-4-chlorophenyl)-3-isopropylurea

C: 150878-29-8
6-chloro-3,4-dihydro-3-isopropyl-4-hydroxy-4-phenyl-2(1H)-quinazolinone

D: 80170-55-4
6-chloro-3,4-dihydro-3-isopropyl-4-phenyl-4-trichloromethyl-2(1H)-quinazolinone

Conditions

Conditions	Yield
In N,N,N,N,N,N-hexamethylphosphoric triamide at 100℃; for 5h;	A 5% B 12% C 35% D 7%

...Expand

: 26381-66-8
5-chloro-2-trichloroacetylaminobenzophenone

: 108-91-8
cyclohexylamine

A: 17387-32-5
5-chloro-2-dichloroacetamidobenzophenone

B: 25514-22-1
1-(2-benzoyl-4-chlorophenyl)-3-cyclohexylurea

C: 719-59-5
2-Amino-5-chlorobenzophenone

D: 80170-81-6
6-chloro-3-cyclohexyl-3,4-dihydro-4-hydroxy-4-phenyl-2(1H)-quinazolinone

Conditions

Conditions	Yield
In N,N,N,N,N,N-hexamethylphosphoric triamide at 100℃; for 7h; Further byproducts given;	A 5% B 31% C 8% D 28%

...Expand

: 26381-66-8
5-chloro-2-trichloroacetylaminobenzophenone

: 108-91-8
cyclohexylamine

A: 25514-22-1
1-(2-benzoyl-4-chlorophenyl)-3-cyclohexylurea

B: 719-59-5
2-Amino-5-chlorobenzophenone

C: 80170-81-6
6-chloro-3-cyclohexyl-3,4-dihydro-4-hydroxy-4-phenyl-2(1H)-quinazolinone

D: 80170-56-5
6-chloro-3-cyclohexyl-3,4-dihydro-4-phenyl-4-trichloromethyl-2(1H)-quinazolinone

Conditions

Conditions	Yield
In N,N,N,N,N,N-hexamethylphosphoric triamide at 100℃; for 7h; Further byproducts given;	A 31% B 8% C 28% D 3%

...Expand

: 4743-17-3
5-Chloroisatoic anhydride

: 71-43-2
benzene

: 719-59-5
2-Amino-5-chlorobenzophenone

Conditions

Conditions	Yield
With aluminium trichloride for 5h; Heating;	31%

: 13788-59-5
N-(2-benzoyl-4-chlorophenyl)acetamide

: 719-59-5
2-Amino-5-chlorobenzophenone

Conditions

Conditions	Yield
With hydrogenchloride

: 21259-25-6
N-Benzoyl-2-amino-5-chlorobenzophenone

: 719-59-5
2-Amino-5-chlorobenzophenone

Conditions

Conditions	Yield
With sulfuric acid
With sodium hydroxide In methanol for 4h; Heating;	1.96 g

: 719-59-5
2-Amino-5-chlorobenzophenone

: 106-95-6
allyl bromide

: 4142-77-2
2-Allylamino-5-chlor-benzophenon

Conditions

Conditions	Yield
With sodium hydroxide; tetrabutylammomium bromide In tetrahydrofuran at 60℃; for 0.5h;	100%

: 719-59-5
2-Amino-5-chlorobenzophenone

: 77-78-1
dimethyl sulfate

: 1022-13-5
5-chloro-2-(methylamino)benzophenone

Conditions

Conditions	Yield
With sodium hydroxide; tetrabutylammomium bromide In tetrahydrofuran at 60℃; for 1h;	100%
With sodium hydroxide; tetrabutylammomium bromide; potassium carbonate In tetrahydrofuran at 30 - 35℃; for 2.5h;	96%

: 126-81-8
dimedone

: 719-59-5
2-Amino-5-chlorobenzophenone

: 7-chloro-3,3-dimethyl-9-phenyl-3,4-dihydro-2H-acridin-1-one

Conditions

Conditions	Yield
With 3-methyl-1-sulfoimidazolium trichloroacetate; trichloroacetic acid In neat (no solvent) at 100℃; Friedlaender Quinoline Synthesis;	100%
With sulfuric acid; silica gel at 100℃; for 2h; Friedlaender synthesis;	99%
KAl(SO4)2*12H2O/SiO2 at 30℃; for 1.5h; Friedlaender synthesis;	99%

: 141-97-9
ethyl acetoacetate

: 719-59-5
2-Amino-5-chlorobenzophenone

: 3-acetyl-6-chloro-4-phenylquinolin-2-(1H)-one

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 153℃; for 19h; Sealed tube;	100%
at 160℃; for 4h; Time;	93%
With Amberlite Na sr1L at 115℃; for 0.0666667h; Microwave irradiation; Neat (no solvent);	92%

: 3132-99-8
m-bromobenzoic aldehyde

: 719-59-5
2-Amino-5-chlorobenzophenone

: 1257084-12-0
2-(3-bromophenyl)-6-chloro-4-phenylquinazoline

Conditions

Conditions	Yield
With copper(II) choride dihydrate; ammonium acetate In ethanol for 4h; Reflux;	100%
With ammonium acetate In ethanol at 60℃; for 1h;	94%
With 1,1,1,3',3',3'-hexafluoro-propanol; ammonium acetate at 55℃; for 0.5h;	92%

: 104-88-1
4-chlorobenzaldehyde

: 719-59-5
2-Amino-5-chlorobenzophenone

: 49797-11-7
6-chloro-2(4-chloro-phenyl)-4-phenyl-quinazoline

Conditions

Conditions	Yield
With copper(II) choride dihydrate; ammonium acetate In ethanol for 4h; Reflux;	100%
With ammonium acetate In ethanol at 60℃; for 1h; Catalytic behavior; Solvent; Temperature; Time;	96%
With ammonium acetate; iodine In neat (no solvent) at 40℃; for 2.5h; Green chemistry;	95%

: 100-52-7
benzaldehyde

: 719-59-5
2-Amino-5-chlorobenzophenone

: 30169-34-7
6-chloro-2,4-diphenyl-quinazoline

Conditions

Conditions	Yield
With copper(II) choride dihydrate; ammonium acetate In ethanol for 4h; Reflux;	100%
With 1-butyl-3-methylimidazolium tetrachloridoferrate(III); ammonium acetate In neat (no solvent) at 40℃; for 2.5h; Green chemistry;	95%
With ammonium acetate In ethanol at 60℃; for 1h;	95%

: 123-11-5
4-methoxy-benzaldehyde

: 719-59-5
2-Amino-5-chlorobenzophenone

: 84570-84-3
6-chloro-2-(4-methoxyphenyl)-4-phenylquinazoline

Conditions

Conditions	Yield
With copper(II) choride dihydrate; ammonium acetate In ethanol for 4h; Reflux;	100%
With ammonium acetate In ethanol at 60℃; for 1h;	95%
With Maltose; N,N'-Dimethylurea; ammonium acetate; ammonium chloride at 90℃; for 2.5h;	91%

: 90-02-8
salicylaldehyde

: 719-59-5
2-Amino-5-chlorobenzophenone

: 52537-82-3
2-(6-chloro-4-phenylquinazoline-2-yl)phenol

Conditions

Conditions	Yield
With copper(II) choride dihydrate; ammonium acetate In ethanol for 4h; Reflux;	100%
With 1-butyl-3-methylimidazolium tetrachloridoferrate(III); ammonium acetate In neat (no solvent) at 40℃; for 2.5h; Green chemistry;	91%
With ammonium acetate In neat (no solvent) at 60℃; Catalytic behavior; Green chemistry;	91%
With Maltose; N,N'-Dimethylurea; ammonium acetate; ammonium chloride at 90℃; for 2.5h;	88%
With ammonium acetate; 1-methyl-1H-imidazolium trifluoroacetate at 80℃; for 2h; Ionic liquid; aerobic oxidation;	87%

: 874-42-0
2,4-dichlorobenzaldeyhde

: 719-59-5
2-Amino-5-chlorobenzophenone

: 1257084-13-1
6-chloro-2-(2,4-dichlorophenyl)-4-phenylquinazoline

Conditions

Conditions	Yield
With copper(II) choride dihydrate; ammonium acetate In ethanol for 4h; Reflux;	100%
With ammonium acetate; 1-methyl-1H-imidazolium trifluoroacetate at 80℃; for 2h; Ionic liquid; aerobic oxidation;	92%
With ammonium acetate In ethanol at 60℃; for 1h;	90%

: 719-59-5
2-Amino-5-chlorobenzophenone

: 552-89-6
2-nitro-benzaldehyde

: 1257084-14-2
6-chloro-2(2-nitro-phenyl)-4-phenyl-quinazoline

Conditions

Conditions	Yield
With copper(II) choride dihydrate; ammonium acetate In ethanol for 4h; Reflux;	100%
With ammonium acetate; iodine In neat (no solvent) at 40℃; for 2.5h; Green chemistry;	93%
With 1-butyl-3-methylimidazolium tetrachloridoferrate(III); ammonium acetate In neat (no solvent) at 40℃; for 2.5h; Green chemistry;	91%

: 455-19-6
4-Trifluoromethylbenzaldehyde

: 719-59-5
2-Amino-5-chlorobenzophenone

: 1372890-80-6
6-chloro-4-phenyl-2-(4-(trifluoromethyl)phenyl)quinazoline

Conditions

Conditions	Yield
With copper(II) choride dihydrate; ammonium acetate In ethanol for 4h; Reflux;	100%
With Maltose; N,N'-Dimethylurea; ammonium acetate; ammonium chloride at 90℃; for 2.33333h;	93%

: 454-89-7
3-Trifluoromethylbenzaldehyde

: 719-59-5
2-Amino-5-chlorobenzophenone

: 49797-17-3
6-chloro-4-phenyl-2-(3-(trifluoromethyl)phenyl)quinazoline

Conditions

Conditions	Yield
With copper(II) choride dihydrate; ammonium acetate In ethanol for 4h; Reflux;	100%
With Maltose; N,N'-Dimethylurea; ammonium acetate; ammonium chloride at 90℃; for 3.33333h;	91%

: 104-87-0
4-methyl-benzaldehyde

: 719-59-5
2-Amino-5-chlorobenzophenone

: 185547-80-2
6-chloro-4-phenyl-2-(p-tolyl)-quinazoline

Conditions

Conditions	Yield
With copper(II) choride dihydrate; ammonium acetate In ethanol for 4h; Reflux;	100%
With ammonium acetate; iodine In neat (no solvent) at 40℃; for 0.5h; Green chemistry;	97%
With ammonium acetate In toluene at 110℃; for 4h; Reflux; Green chemistry;	95%

: 719-59-5
2-Amino-5-chlorobenzophenone

: 100-83-4
meta-hydroxybenzaldehyde

: 3-(6-chloro-4-phenylquinazolin-2-yl)phenol

Conditions

Conditions	Yield
With copper(II) choride dihydrate; ammonium acetate In ethanol for 4h; Reflux;	100%
With 1,1,1,3',3',3'-hexafluoro-propanol; ammonium acetate at 55℃; for 1.5h;	85%

: 719-59-5
2-Amino-5-chlorobenzophenone

: 591-31-1
3-methoxy-benzaldehyde

: 6-chloro-2-(3-methoxyphenyl)-4-phenylquinazoline

Conditions

Conditions	Yield
With copper(II) choride dihydrate; ammonium acetate In ethanol for 4h; Reflux;	100%
With 1,1,1,3',3',3'-hexafluoro-propanol; ammonium acetate at 55℃; for 1h;	90%

: 719-59-5
2-Amino-5-chlorobenzophenone

: 135-02-4
ortho-anisaldehyde

: 6-chloro-2-(2-methoxyphenyl)-4-phenylquinazoline

Conditions

Conditions	Yield
With copper(II) choride dihydrate; ammonium acetate In ethanol for 4h; Reflux;	100%
With 1,1,1,3',3',3'-hexafluoro-propanol; ammonium acetate at 55℃; for 1.5h;	86%

: 719-59-5
2-Amino-5-chlorobenzophenone

: 3446-89-7
4-(Methylthio)benzaldehyde

: 6-chloro-2-[4-(methylsulfanyl)phenyl]-4-phenylquinazoline

Conditions

Conditions	Yield
With copper(II) choride dihydrate; ammonium acetate In ethanol for 4h; Reflux;	100%
With 1,1,1,3',3',3'-hexafluoro-propanol; ammonium acetate at 55℃; for 1.5h;	84%

: 99-61-6
3-nitro-benzaldehyde

: 719-59-5
2-Amino-5-chlorobenzophenone

: 49797-14-0
6-Chloro-2-(3-nitro-phenyl)-4-phenyl-quinazoline

Conditions

Conditions	Yield
With copper(II) choride dihydrate; ammonium acetate In ethanol for 4h; Reflux;	100%
With 1,1,1,3',3',3'-hexafluoro-propanol; ammonium acetate at 55℃; for 1.16667h;	90%

: 719-59-5
2-Amino-5-chlorobenzophenone

: 1159372-20-9
(2-amino-5-chlorophenyl)(phenyl)methanol

Conditions

Conditions	Yield
With sodium tetrahydroborate In isopropyl alcohol at 60℃; for 3.5h;	99%
With sodium tetrahydroborate In methanol at 50℃; for 1h;	98%
With sodium tetrahydroborate In ethanol	98%

: 719-59-5
2-Amino-5-chlorobenzophenone

: 120-92-3
cyclopentanone

: 7-Chloro-9-phenyl-2,3-dihydro-1H-cyclopenta[b]quinoline

Conditions

Conditions	Yield
sulfuric acid for 0.116667h; Friedlaender quinoline synthesis; microwave irradiation;	99%
With 3-methyl-1-sulfoimidazolium trichloroacetate; trichloroacetic acid In neat (no solvent) at 100℃; Friedlaender Quinoline Synthesis;	99%
With phosphoric acid triphenyl ester at 130℃; for 4h;	97%

: 719-59-5
2-Amino-5-chlorobenzophenone

: 123-54-6
acetylacetone

: 22609-02-5
1-(6-chloro-2-methyl-4-phenylquinolin-3-yl)ethanone

Conditions

Conditions	Yield
With sulfuric acid; silica gel at 100℃; for 0.75h; Friedlaender synthesis;	99%
With 3-methyl-1-sulfoimidazolium trichloroacetate; trichloroacetic acid In neat (no solvent) at 100℃; Friedlaender Quinoline Synthesis;	99%
With tin(ll) chloride at 20℃; for 0.5h;	98%

: 719-59-5
2-Amino-5-chlorobenzophenone

: 407-25-0
trifluoroacetic anhydride

: 69559-40-6
N-(2-benzoyl-4-chlorophenyl)-2,2,2-trifluoroacetamide

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃; for 12h;	99%
With triethylamine In dichloromethane at -78 - 20℃; for 0.166667h;

: 108-94-1
cyclohexanone

: 719-59-5
2-Amino-5-chlorobenzophenone

: 116690-69-8
6-chloro-10-phenyl-1,2,3,4-tetrahydroacridine

Conditions

Conditions	Yield
With CuBTC metal-organic-framework at 89.84℃; for 5h; Friedlaender reaction; Neat (no solvent);	99%
With 1-butylimidazolium tetrafluoroborate at 100℃; for 3h; Friedlaender reaction;	98%
With tin(ll) chloride at 20℃; for 2.33333h;	96%

: 141-97-9
ethyl acetoacetate

: 719-59-5
2-Amino-5-chlorobenzophenone

: 22609-01-4
ethyl 6-chloro-2-methyl-4-phenylquinoline-3-carboxylate

Conditions

Conditions	Yield
With magnesium(II) perchlorate In ethanol at 60℃; for 18h; Friedlaender synthesis;	99%
scandium tris(dodecyl sulfate) In water at 40℃; Friedlaender annulation;	99%
With cuprous triflate at 20℃; for 2h; Friedlaender synthesis; neat (no solvent);	99%

: 719-59-5
2-Amino-5-chlorobenzophenone

: 762-42-5
dimethyl acetylenedicarboxylate

: 10037-28-2
dimethyl 4-phenyl-6-chloroquinoline-2,3-dicarboxylate

Conditions

Conditions	Yield
With propylphosphonium tetrachloroindate ionic liquid supported on nanosilica In neat (no solvent) at 110℃; for 0.5h; Reagent/catalyst; Temperature;	99%
With indium(III) chloride at 80℃; for 0.833333h; regioselective reaction;	96%
Stage #1: dimethyl acetylenedicarboxylate With pyridine at 0 - 10℃; for 0.25h; Stage #2: 5-chloro-2-aminobenzophenone at 20℃; for 12h;	89%

: 719-59-5
2-Amino-5-chlorobenzophenone

: 56-40-6
glycine

: 4015-28-5
6-chloro-4-phenylquinazoline

Conditions

Conditions	Yield
With tert.-butylhydroperoxide; iodine In ISOPROPYLAMIDE; water at 80℃; for 4h; Sealed tube;	99%

: 719-59-5
2-Amino-5-chlorobenzophenone

: 501-65-5
diphenyl acetylene

: 1208258-68-7
6-chloro-2,3,4-triphenylquinoline

Conditions

Conditions	Yield
With 18-crown-6 ether; trifluorormethanesulfonic acid; palladium diacetate; 1,2-bis-(diphenylphosphino)ethane In toluene; acetonitrile at 100℃; for 12h; Reagent/catalyst; Solvent; Sealed tube;	98.1%
With propylphosphonium tetrachloroindate ionic liquid supported on nanosilica In neat (no solvent) at 110℃; for 1h;	67%
With acetic acid; palladium(II) bromide In benzonitrile; 1,2-dichloro-ethane at 130℃; for 18h; Sealed tube;	51%

: 719-59-5
2-Amino-5-chlorobenzophenone

: 98-58-8
4-bromobenzenesulfonyl chloride

: N-(2-Benzoyl-4-chloro-phenyl)-4-bromo-benzenesulfonamide

Conditions

Conditions	Yield
In pyridine; hydrogenchloride	98%
	39%

2-Amino-5-chlorobenzophenone Chemical Properties

IUPAC Name: (2-amino-5-chlorophenyl)-phenylmethanone
Empirical Formula: C₁₃H₁₀ClNO
Molecular Weight: 231.6776g/mol
EINECS: 211-949-7
Structure of 2-Amino-5-chlorobenzophenone (CAS NO.719-59-5):

Index of Refraction: 1.636
Molar Refractivity: 65.17 cm³
Molar Volume: 181.7 cm³
Polarizability: 25.83×10^-24cm³
Surface Tension: 52.2 dyne/cm
Density: 1.274 g/cm³
Flash Point: 210.4 °C
Enthalpy of Vaporization: 67.87 kJ/mol
Melting Point: 96-98 °C(lit.)
Boiling Point: 424.3 °C at 760 mmHg
Vapour Pressure: 2.09E-07 mmHg at 25°C
Stability: Stable. Incompatible with strong oxidizing agents.
Product Categories: Benzene derivatives;FINE Chemical & INTERMEDIATES;Aromatic Benzophenones & Derivatives (substituted);ketone;Diazepam
Canonical SMILES: C1=CC=C(C=C1)C(=O)C2=C(C=CC(=C2)Cl)N
InChI: InChI=1S/C13H10ClNO/c14-10-6-7-12(15)11(8-10)13(16)9-4-2-1-3-5-9/h1-8H,15H2
InChIKey: ZUWXHHBROGLWNH-UHFFFAOYSA-N

2-Amino-5-chlorobenzophenone Toxicity Data With Reference

ipr-mus LD50:681 mg/kg

IJSIDW Indian Journal of Pharmaceutical Sciences. (Indian Journal of Pharmaceutical Sciences, Kalina, Santa Cruz 44 (1982),1.

2-Amino-5-chlorobenzophenone Consensus Reports

Reported in EPA TSCA Inventory.

2-Amino-5-chlorobenzophenone Safety Profile

Moderately toxic by intraperitoneal route. When heated to decomposition it emits toxic vapors of NO_x and Cl⁻.
Hazard Codes: Xi,Xn
The Risk Statements information of 2-AMINO-5-CHLOROBENZOPHENONE :
22: Harmful if swallowed
20/21/22: Harmful by inhalation, in contact with skin and if swallowed
36/37/38: Irritating to eyes, respiratory system and skin
The Safety Statements information of 2-AMINO-5-CHLOROBENZOPHENONE :
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
WGK Germany: 3
RTECS: PC4933500
HS Code: 29223900

2-Amino-5-chlorobenzophenone Specification

2-Amino-5-chlorobenzophenone , its cas register number is 719-59-5. It also can be called (2-Amino-5-chlorophenyl)phenylmethanone ; 2-Benzoyl-4-chloroaniline ; 3-14-00-00214 (Beilstein Handbook Reference) ; 5-Chloro-2-aminobenzophenone . 2-Amino-5-chlorobenzophenone (CAS NO.719-59-5) is a yellow powder.

Product Name

2-Amino-5-chlorobenzophenone

Synthetic route

2-Amino-5-chlorobenzophenone Chemical Properties

2-Amino-5-chlorobenzophenone Toxicity Data With Reference

2-Amino-5-chlorobenzophenone Consensus Reports

2-Amino-5-chlorobenzophenone Safety Profile

2-Amino-5-chlorobenzophenone Specification

Related Products

Hot Products