2-Bromofluorobenzene supplier

Name
2-Bromofluorobenzene
EINECS 214-018-3
CAS No. 1072-85-1
Article Data42
CAS DataBase
Density 1.593 g/cm³
Solubility insoluble in water
Melting Point -8°C
Formula C₆H₄BrF
Boiling Point 151.5 °C at 760 mmHg
Molecular Weight 175
Flash Point 50.2 °C
Transport Information UN 1993 3/PG 3
Appearance clear colourless to light yellow liquid
Safety 26-36-37/39-16
Risk Codes 10-36/37/38-22-20/21/22
Molecular Structure
Hazard Symbols Xn
Synonyms 1-Bromo-2-fluoro-5-(trifluoromethyl)benzene;1-Bromo-2-fluorobenzene;1-Fluoro-2-bromobenzene;2-Bromo-1-fluorobenzene;2-Bromophenyl fluoride;2-Fluorobromobenzene;2-Fluorophenyl bromide;NSC59696;o-Bromofluorobenzene;o-Fluorobromobenzene;
PSA 0.00000
LogP 2.58820

Synthetic route

: 615-36-1
2-bromoaniline

: 1072-85-1
o-fluorobromobenzene

Conditions

Conditions	Yield
	90%

: 1202186-81-9
(2-fluorophenyl)(mesityl)iodonium trifluoromethanesulfonate

: 1072-85-1
o-fluorobromobenzene

Conditions

Conditions	Yield
With copper(I) bromide In acetonitrile at 80℃; for 2h;	71%

: 462-06-6
fluorobenzene

A: 1072-85-1
o-fluorobromobenzene

B: 460-00-4
1-Bromo-4-fluorobenzene

Conditions

Conditions	Yield
With lead(IV) acetate; trifluoroacetic acid; potassium bromide at 25℃; for 0.5h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
With manganese triacetate; trifluoroacetic acid; potassium bromide for 72h; Product distribution; Ambient temperature; Co(CH3COO)3, 67percent aq. CF3COOH, 15 - 10 h;
With potassium nitrate; potassium bromide In water; trifluoroacetic acid at 20℃; for 10h; Product distribution; under argon;

: 462-06-6
fluorobenzene

A: 1072-85-1
o-fluorobromobenzene

B: 1435-53-6
2,4-dibromo-1-fluorobenzene

C: 3925-78-8
2,4,6-Tribromofluorobenzene

D: 359-90-0
1-Fluoro-1,2,3,4,5,6-hexabromocyclohexane

E: 460-00-4
1-Bromo-4-fluorobenzene

Conditions

Conditions	Yield
With bromine In trichlorofluoromethane for 42h; Irradiation; other compounds: o-, m-, p-difluorobenzene;

...Expand

: 462-06-6
fluorobenzene

A: 1072-85-1
o-fluorobromobenzene

B: 1435-53-6
2,4-dibromo-1-fluorobenzene

C: 359-90-0
1-Fluoro-1,2,3,4,5,6-hexabromocyclohexane

D: 460-00-4
1-Bromo-4-fluorobenzene

Conditions

Conditions	Yield
With bromine In trichlorofluoromethane for 42h; Irradiation; Yield given. Further byproducts given. Yields of byproduct given. Title compound not separated from byproducts;

...Expand

: 108-86-1
bromobenzene

A: 1072-85-1
o-fluorobromobenzene

B: 1073-06-9
3-fluorobromobenzene

C: 460-00-4
1-Bromo-4-fluorobenzene

Conditions

Conditions	Yield
With fluorine In trichlorofluoromethane at -78℃; for 1h;	A 23 % Chromat. B 17 % Chromat. C 60 % Chromat.
With fluorine In trichlorofluoromethane at -78℃; for 1h; Rate constant; Product distribution; competitive reaction with benzene;	A 23 % Chromat. B 17 % Chromat. C 60 % Chromat.
With xenon difluoride; boron trifluoride diethyl etherate In acetonitrile at -35 - 20℃; for 2.5h; Inert atmosphere; Overall yield = 56 %;

...Expand

: (4-Bromo-3-fluoro-phenyl)-trimethyl-silane

: 1072-85-1
o-fluorobromobenzene

Conditions

Conditions	Yield
With potassium fluoride In N,N-dimethyl-formamide at 80℃; for 3h; Yield given;

: 348-51-6
1-chloro-2-fluorobenzene

: 1072-85-1
o-fluorobromobenzene

Conditions

Conditions	Yield
With bromobenzene; Cu-HZSM-5 zeolite at 399.9℃; Mechanism;	11.2 % Chromat.

2-bromo-benzenediazonium-(1)-hexafluoro phosphate: 2-bromo-benzenediazonium-(1)-hexafluoro phosphate

: 1072-85-1
o-fluorobromobenzene

2-bromo-benzenediazonium-(1)-tetrafluoroborate: 2-bromo-benzenediazonium-(1)-tetrafluoroborate

: 1072-85-1
o-fluorobromobenzene

: 462-06-6
fluorobenzene

: 7726-95-6
bromine

: 1072-85-1
o-fluorobromobenzene

Conditions

Conditions	Yield
Leiten durch ein Quarz-Rohr bei Temperaturen von 260grad bis 680grad;
Leiten durch ein Pyrex-Rohr bei Temperaturen von 425grad bis 475grad;

: 462-06-6
fluorobenzene

: 7726-95-6
bromine

iron: iron

A: 1072-85-1
o-fluorobromobenzene

B: 460-00-4
1-Bromo-4-fluorobenzene

Conditions

Conditions	Yield
at 100℃;

...Expand

: 75-15-0
carbon disulfide

: 462-06-6
fluorobenzene

: 7726-95-6
bromine

aluminium: aluminium

A: 1072-85-1
o-fluorobromobenzene

B: 1073-06-9
3-fluorobromobenzene

C: 460-00-4
1-Bromo-4-fluorobenzene

Conditions

Conditions	Yield
at 55℃; Product distribution;

...Expand

: 56-23-5
tetrachloromethane

: 462-06-6
fluorobenzene

iodo monobromide: iodo monobromide

A: 1072-85-1
o-fluorobromobenzene

B: 1073-06-9
3-fluorobromobenzene

C: 352-34-1
4-fluoro-1-iodobenzene

D: 460-00-4
1-Bromo-4-fluorobenzene

Conditions

Conditions	Yield
Product distribution;

...Expand

: 462-06-6
fluorobenzene

A: 1072-85-1
o-fluorobromobenzene

B: 1073-06-9
3-fluorobromobenzene

C: 460-00-4
1-Bromo-4-fluorobenzene

D HBr: HBr

Conditions

Conditions	Yield
With bromine at 25℃; for 16h; Irradiation; Yield given;

...Expand

: 1993-03-9
o-fluorophenylboronic acid

: 1072-85-1
o-fluorobromobenzene

Conditions

Conditions	Yield
With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; sodium methylate In methanol; water; acetonitrile at 40℃; for 4h;	98 % Chromat.

: 108-86-1
bromobenzene

A: 1072-85-1
o-fluorobromobenzene

B: 1000995-64-1
2-bromo-1-oxypentafluorosulfanylbenzene

C: 344455-90-9
4-bromo-1-oxypentafluorosulfanylbenzene

D: 3-bromo-1-oxypentafluorosulfanylbenzene

E: C6H3FBrOSF5

F: C6H3FBrOSF5

G: C6H3FBrOSF5

H: C6H3FBrOSF5

I: C6H3FBrOSF5

J: C6H3FBrOSF5

K: C6H3FBrOSF5

L: C6H3FBrOSF5

M: C6H3FBrOSF5

N: C6H3FBrOSF5

O: C6H4(OSF5)2

P: C6H4(OSF5)2

Q: C6H4(OSF5)2

R: 1073-06-9
3-fluorobromobenzene

S: 108-36-1
1,3-dibromobenzene

T: 106-37-6
1.4-dibromobenzene

U: 460-00-4
1-Bromo-4-fluorobenzene

V: 583-53-9
1,2-dibromobenzene

Conditions

Conditions	Yield
With bis(pentafluorosulfur) peroxide at 100℃; for 17h;

...Expand

: 108-86-1
bromobenzene

A: 1072-85-1
o-fluorobromobenzene

B: 1000995-64-1
2-bromo-1-oxypentafluorosulfanylbenzene

C: 344455-90-9
4-bromo-1-oxypentafluorosulfanylbenzene

D: 3-bromo-1-oxypentafluorosulfanylbenzene

E: C6H3BrClOSF5

F: C6H3BrClOSF5

G: C6H3BrClOSF5

H: C6H3BrClOSF5

I: C6H3BrClOSF5

J: C6H3BrClOSF5

K: C6H3BrClOSF5

L: C6H3BrClOSF5

M: C6H3BrClOSF5

N: C6H3BrClOSF5

O: C6H4(OSF5)2

P: C6H4(OSF5)2

Q: C6H4(OSF5)2

R: 1073-06-9
3-fluorobromobenzene

S: 108-36-1
1,3-dibromobenzene

T: 106-37-6
1.4-dibromobenzene

U: 460-00-4
1-Bromo-4-fluorobenzene

V: 583-53-9
1,2-dibromobenzene

Conditions

Conditions	Yield
With bis(pentafluorosulfur) peroxide In dichloromethane at 150℃; for 22h;

...Expand

: 128254-27-3
2-Fluoro-1,4-bis-trimethylsilanyl-benzene

: 1072-85-1
o-fluorobromobenzene

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: Br2 2: KF / dimethylformamide / 3 h / 80 °C View Scheme

: 615-36-1
2-bromoaniline

A: 1072-85-1
o-fluorobromobenzene

B: o-bromobenzene diazonium fluoride

Conditions

Conditions	Yield
With hydrogen fluoride; sodium nitrite

: C14H13BrN3Pol

: 1072-85-1
o-fluorobromobenzene

Conditions

Conditions	Yield
With tetrafluoroboric acid diethyl ether In tetradecafluorohexane at 100℃; for 1h; Balz-Schiemann reaction; Autoclave; solid phase reaction;	52 %Chromat.

: 1007-16-5
3-bromo-4-fluorobenzoic acid

: 1072-85-1
o-fluorobromobenzene

Conditions

Conditions	Yield
With dipotassium peroxodisulfate; silver(I) acetate In acetonitrile at 100℃; for 24h;

: 348-52-7
1-Fluoro-2-iodobenzene

: 1072-85-1
o-fluorobromobenzene

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 3-chloro-benzenecarboperoxoic acid 2: copper(I) bromide / acetonitrile / 2 h / 80 °C View Scheme

: 108-86-1
bromobenzene

A: 1072-85-1
o-fluorobromobenzene

B: 399-94-0
2-bromo-1,4-difluorobenzene

C: 1073-06-9
3-fluorobromobenzene

D: 348-61-8
1-bromo-3,4-difluorobenzene

E: 460-00-4
1-Bromo-4-fluorobenzene

Conditions

Conditions	Yield
With xenon difluoride; boron trifluoride diethyl etherate at 0 - 25℃; Cooling with ice;	A 0.06 mmol B 0.01 mmol C 0.03 mmol D 0.004 mmol E 0.16 mmol

...Expand

: 108-86-1
bromobenzene

A: 1072-85-1
o-fluorobromobenzene

B: 460-00-4
1-Bromo-4-fluorobenzene

Conditions

Conditions	Yield
With 2-chloro-[1,10]phenanthroline; {Pd(2,2':6',2''-terpyridine)(acetonitrile)}(BF4)2; Selectfluor In acetonitrile at 50℃; for 12h; Reagent/catalyst; Temperature;
With [(terpy)Pd(2-Cl-phen)][BF4]; Selectfluor In acetonitrile at 50℃; Overall yield = 49 %Spectr.;

: 244205-40-1
(2-bromophenyl)boronic acid

: 1072-85-1
o-fluorobromobenzene

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: potassium fluoride / acetonitrile / 16 h / 90 °C 2: 2,6-dichloro-1-fluoropyridin-1-ium tetrafluoroborate / chloroform / 6 h / 60 °C View Scheme

: C19H12BiBrF3NOS

: 1072-85-1
o-fluorobromobenzene

Conditions

Conditions	Yield
With 2,6-dichloro-1-fluoropyridin-1-ium tetrafluoroborate In chloroform at 60℃; for 6h;	74 %Spectr.

: 88-65-3
2-bromobenzoic-acid

: 1072-85-1
o-fluorobromobenzene

Conditions

Conditions	Yield
Stage #1: 2-bromobenzoic-acid With tetrakis(acetonitrile)copper(I)tetrafluoroborate; tetrabutylammonium tetra(tert-butyl alcohol) coordinate fluoride; copper(II) bis(trifluoromethanesulfonate) In acetonitrile at 23℃; for 0.5h; Sealed tube; Inert atmosphere; Stage #2: In acetonitrile at 35℃; for 6h; Irradiation; Sealed tube; Inert atmosphere;	85 %Spectr.

: 1072-85-1
o-fluorobromobenzene

: 701-45-1
2-bromo-1-fluoro-4-nitrobenzene

Conditions

Conditions	Yield
With sulfuric acid; nitric acid at 20℃; for 16h;	100%
With sulfuric acid; nitric acid In water at 10 - 20℃;	89%
With sulfuric acid; nitric acid at 10 - 20℃;	89%

: 1072-85-1
o-fluorobromobenzene

: 22988-70-1
6-amino-2,3,5-trimethylbenzo[b]thiophene

: 6-(2-fluorophenyl)amino-2,3,5-trimethylbenzo[b]thiophene

Conditions

Conditions	Yield
With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In toluene at 100℃; for 21h; Buchwald-Hartwig coupling;	100%
With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In toluene at 100℃; for 21h;	100%

: 1072-85-1
o-fluorobromobenzene

: 348-54-9
2-Fluoroaniline

: 328-15-4
N,N-bis(2-fluorophenyl)amine

Conditions

Conditions	Yield
With potassium tert-butylate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In toluene for 24h; Heating / reflux;	100%
Stage #1: o-fluorobromobenzene; 2-Fluoroaniline With sodium t-butanolate; palladium diacetate; bis[2-(diphenylphosphino)phenyl] ether In toluene for 24h; Heating / reflux; Stage #2: With water In toluene	91.4%
With sodium t-butanolate; palladium diacetate; bis[2-(diphenylphosphino)phenyl] ether In toluene for 24h; Heating / reflux;	91.4%
With tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate In toluene at 110℃; for 16h; Buchwald-Hartwig Coupling;	89%
With tri-tert-butyl phosphine; sodium t-butanolate; palladium diacetate In toluene at 90℃; for 16h;	78%

: 1072-85-1
o-fluorobromobenzene

: 150-76-5
4-methoxy-phenol

: 1-bromo-2-(4-methoxyphenoxy)benzene

Conditions

Conditions	Yield
With TMS-NEt2; phosphazene base t-Bu-P4 In hexane; N,N-dimethyl-formamide at 100℃; for 48h;	100%

: 1072-85-1
o-fluorobromobenzene

: 685-83-6
bis(diethylamino)chlorophosphine

: 1219134-57-2
(ortho-F-C6H4)P(NEt2)2

Conditions

Conditions	Yield
Stage #1: o-fluorobromobenzene With n-butyllithium In diethyl ether; hexenes at -89 - -85℃; for 3h; Inert atmosphere; Stage #2: bis(diethylamino)chlorophosphine In diethyl ether; hexenes at -100 - 20℃; Inert atmosphere;	100%

: 1072-85-1
o-fluorobromobenzene

: 388-82-9
2,2'-difluorobiphenyl

Conditions

Conditions	Yield
With monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene; (C5H5)2Zr(OC4H8)N(Si(CH3)3)CH(C6H5); bis(dibenzylideneacetone)-palladium(0) In toluene at 80℃; for 16h; Sealed tube; Inert atmosphere;	99%
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; cesium fluoride In dimethyl sulfoxide at 100℃; for 1.5h;	90%
Ni-2,2'-dipyridylamine In ethanol at 20℃; Reduction; Electrolysis;	68%

: 1072-85-1
o-fluorobromobenzene

: 363-72-4
Pentafluorobenzene

: 41877-27-4
2'-fluoro-2,3,4,5,6-pentafluoro-1,1'-biphenyl

Conditions

Conditions	Yield
With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; potassium carbonate In Isopropyl acetate at 80℃; for 12h;	99%

: 1072-85-1
o-fluorobromobenzene

: 51-17-2
benzoimidazole

: 1198007-13-4
1-(2-bromophenyl)-1H-benzo[d]imidazole

Conditions

Conditions	Yield
With potassium phosphate In N,N-dimethyl-formamide at 150℃;	99%
With potassium phosphate In N,N-dimethyl-formamide at 190℃; for 1h; Microwave irradiation;	86%
With caesium carbonate In N,N-dimethyl acetamide

: 1072-85-1
o-fluorobromobenzene

: 582-60-5
5,6-dimethyl-1H-benzo[d]imida-zole

: 1-(2-bromophenyl)-5,6-dimethylbenzimidazole

Conditions

Conditions	Yield
With potassium phosphate In N,N-dimethyl-formamide at 150℃;	99%

: 1072-85-1
o-fluorobromobenzene

: 1060735-14-9
9-phenyl-3,3'-bicarbazole

: C36H23BrN2

Conditions

Conditions	Yield
With caesium carbonate In 1-methyl-pyrrolidin-2-one at 170℃; for 24h; Inert atmosphere;	99%

: 1072-85-1
o-fluorobromobenzene

: 98-80-6
phenylboronic acid

: 321-60-8
2-fluorobiphenyl

Conditions

Conditions	Yield
With caesium carbonate; palladium diacetate In toluene at 80℃; for 10h; Suzuki-Miyaura cross-coupling;	98%
With potassium carbonate In ethanol; water at 20℃; for 6h; Suzuki-Miyaura coupling;	91%
With potassium carbonate; bis(η3-allyl)palladium; Tedicyp In xylene at 140℃; for 20h; Suzuki cross-coupling;	87%

: 1072-85-1
o-fluorobromobenzene

: 5292-43-3
bromoacetic acid tert-butyl ester

: 476429-08-0
tert-butyl α-(2-fluorophenyl)acetate

Conditions

Conditions	Yield
Stage #1: bromoacetic acid tert-butyl ester With zinc In tetrahydrofuran at 20℃; for 0.166667h; Inert atmosphere; Sealed tube; Stage #2: o-fluorobromobenzene With monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene; bis(dibenzylideneacetone)-palladium(0) In tetrahydrofuran at 20℃; for 4h; Inert atmosphere; Sealed tube;	98%

: 1072-85-1
o-fluorobromobenzene

: 201230-82-2
carbon monoxide

: 20680-59-5
3-methylbenzenecarboximidamide hydrochloride

: 18818-40-1
2-(3-methylphenyl)-4(3H)-quinazolinone

Conditions

Conditions	Yield
With palladium diacetate; N-ethyl-N,N-diisopropylamine; catacxium A In N,N-dimethyl acetamide at 140℃; under 7500.75 Torr; for 22h; Inert atmosphere; Autoclave;	98%

...Expand

: 1072-85-1
o-fluorobromobenzene

: 4246-51-9
4,7,10-trioxa-1,13-diaminotridecane

: N,N'-(((oxybis(ethan-2,1-diyl))bis(oxy))bis(propane-3,1-diyl))bis(2-fluoroaniline)

Conditions

Conditions	Yield
Stage #1: o-fluorobromobenzene With 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; bis(dibenzylideneacetone)-palladium(0) In 1,4-dioxane Inert atmosphere; Stage #2: 4,7,10-trioxa-1,13-diaminotridecane With sodium t-butanolate In 1,4-dioxane for 8h; Reagent/catalyst; Reflux;	98%

: 1072-85-1
o-fluorobromobenzene

: 121-43-7
Trimethyl borate

: 1993-03-9
o-fluorophenylboronic acid

Conditions

Conditions	Yield
Stage #1: o-fluorobromobenzene With n-butyllithium In tetrahydrofuran; hexane at -30℃; Inert atmosphere; Flow reactor; Stage #2: Trimethyl borate In tetrahydrofuran; hexane at -30℃; Inert atmosphere; Flow reactor;	97%

: 1072-85-1
o-fluorobromobenzene

: 56138-96-6
2,6-diphenylmethyl-4-methylaniline

: C39H32FN

Conditions

Conditions	Yield
With C36H37NP2; bis(dibenzylideneacetone)-palladium(0); sodium t-butanolate In toluene at 110℃; for 120h; Temperature; Reagent/catalyst; Inert atmosphere; Schlenk technique; Glovebox;	97%

: 1072-85-1
o-fluorobromobenzene

: 6-(6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl)-6-azaspiro[3.4]octan-2-amine trifluoroacetate

: C21H20F4N4S

Conditions

Conditions	Yield
With tris-(dibenzylideneacetone)dipalladium(0); dicyclohexyl-(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine; sodium t-butanolate In 1,4-dioxane at 130℃; for 12h; Inert atmosphere;	97%

: 1072-85-1
o-fluorobromobenzene

: 75230-49-8
N′-(1-(4-fluorophenyl)ethylidene)-4-methylbenzenesulfonohydrazide

: 1-(2-Fluorophenyl)-1-(4-fluorophenyl)-ethene

Conditions

Conditions	Yield
With tris-(dibenzylideneacetone)dipalladium(0); di(1-adamantyl)-4-(N,N-dimethyl)amino-phenyl-phosphane trifluoroacetic acid; lithium tert-butoxide In 1,4-dioxane; water at 110℃; Sealed tube; Inert atmosphere;	97%

: 1072-85-1
o-fluorobromobenzene

: 102632-49-5
1,1-bis(1-methyl-2,3,4,5-tetraphenyl-1-silacyclopentadiene)

: 7,7'-bis(7-methyl-1,4,5,6-tetraphenyl-7-sila-2,3-benzonorbornadiene)

Conditions

Conditions	Yield
With magnesium In tetrahydrofuran	96%

: 1072-85-1
o-fluorobromobenzene

: 764-48-7
2-hydroxyethyl vinyl ether

: 261966-94-3
2-(2-fluorophenyl)-2-methyl-1,3-dioxolane

Conditions

Conditions	Yield
With 1,3-bis-(diphenylphosphino)propane; triethylamine; 1-butyl-3-methylimidazolium Tetrafluoroborate; palladium diacetate at 115℃; for 24h; Heck reaction;	96%
With 1,3-bis-(diphenylphosphino)propane; palladium diacetate; triethylamine In ethylene glycol at 145℃; Heck reaction; Inert atmosphere; regioselective reaction;	77%

: 1072-85-1
o-fluorobromobenzene

: 205-25-4
benzo[c]carbazole

: 7-(2-bromophenyl)-7H-benzo[c]carbazole

Conditions

Conditions	Yield
With caesium carbonate In N,N-dimethyl-formamide at 150℃; for 6h;	96%
With caesium carbonate In N,N-dimethyl-formamide at 150℃; for 12h; Inert atmosphere;	92%

: 1072-85-1
o-fluorobromobenzene

: 683-85-2
N,N-dimethylaminodichlorophosphane

: bis(2-fluorophenyl)dimethylaminophosphine

Conditions

Conditions	Yield
Stage #1: o-fluorobromobenzene With n-butyllithium In diethyl ether at -85 - -75℃; for 1h; Stage #2: N,N-dimethylaminodichlorophosphane In diethyl ether at -85 - 20℃;	95.95%

: 1072-85-1
o-fluorobromobenzene

A: 462-06-6
fluorobenzene

B: 388-82-9
2,2'-difluorobiphenyl

Conditions

Conditions	Yield
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; cesium fluoride In 2-pentanol at 100℃; for 18h; Inert atmosphere;	A 95.5% B 4.5%
With palladium; hydroquinone; potassium hydroxide In glycerol at 90℃; for 18h; chemoselective reaction;	A n/a B 71 %Chromat.

: 1072-85-1
o-fluorobromobenzene

: 100-51-6
benzyl alcohol

: 31575-75-4
2-bromophenyl benzyl ether

Conditions

Conditions	Yield
With 1-methyl-pyrrolidin-2-one; sodium hydride at 100℃; for 1h;	95%

: 1072-85-1
o-fluorobromobenzene

: 918630-49-6
1-cyano-2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)naphthalene

: 918630-57-6
1-cyano-2-(2-fluorophenyl)naphthalene

Conditions

Conditions	Yield
With potassium carbonate; tetrakis(triphenylphosphine) palladium(0) In ethanol; toluene at 100℃; for 6h;	95%

: 1072-85-1
o-fluorobromobenzene

: 1069-08-5
diethylphosphoramidous dichloride

: 1065188-97-7
(ortho-F-C6H4)2P-NEt2

Conditions

Conditions	Yield
Stage #1: o-fluorobromobenzene With n-butyllithium In diethyl ether; hexane at -85 - -78℃; for 3h; Stage #2: diethylphosphoramidous dichloride In diethyl ether; hexane at -85 - -10℃;	95%
Stage #1: o-fluorobromobenzene With n-butyllithium In diethyl ether; hexane at -85 - -78℃; for 3h; Stage #2: diethylphosphoramidous dichloride In diethyl ether; hexane at -85 - -10℃;	95%
Stage #1: o-fluorobromobenzene With n-butyllithium In diethyl ether; hexane at -85 - -78℃; for 3h; Stage #2: diethylphosphoramidous dichloride In diethyl ether; hexane at -85 - -10℃;	95%
Stage #1: o-fluorobromobenzene With n-butyllithium In diethyl ether; hexane at -85℃; for 3h; Inert atmosphere; Stage #2: diethylphosphoramidous dichloride In diethyl ether; hexane at -85 - -10℃;	95%
Stage #1: o-fluorobromobenzene With n-butyllithium In diethyl ether; hexane at -85 - -78℃; for 3h; Stage #2: diethylphosphoramidous dichloride In diethyl ether; hexane at -85 - -10℃;	95%

: 1072-85-1
o-fluorobromobenzene

: thieno<2,3-b>indole

: C16H10BrNS

Conditions

Conditions	Yield
With caesium carbonate In N,N-dimethyl-formamide at 150℃; for 12h; Inert atmosphere;	94.7%
With caesium carbonate In N,N-dimethyl-formamide at 150℃; for 12h; Inert atmosphere;	94.7%

: 1072-85-1
o-fluorobromobenzene

: 1257220-47-5
12,12-dimethyl-10,12-dihydro-10-azaindeno[2,1-b]fluorene

: 5-(2-bromophenyl)-7,7-dimethyl-5,7-dihydroindeno[2,1-b]carbazole

Conditions

Conditions	Yield
With caesium carbonate In N,N-dimethyl-formamide for 6h; Reflux;	94.7%

: 1072-85-1
o-fluorobromobenzene

: 102632-49-5
1,1-bis(1-methyl-2,3,4,5-tetraphenyl-1-silacyclopentadiene)

: 102649-09-2
11,11'-Dimethyl-1,8,9,10,1',8',9',10'-octaphenyl-[11,11']bi[11-sila-tricyclo[6.2.1.02,7]undecyl]-2(7),3,5,9,2'(7'),3',5',9'-octaene

Conditions

Conditions	Yield
With magnesium In tetrahydrofuran	94%

: 1072-85-1
o-fluorobromobenzene

: 115-19-5
2-methyl-but-3-yn-2-ol

: 178173-84-7
4-(2-fluoro-phenyl)-2-methyl-but-3-yn-2-ol

Conditions

Conditions	Yield
With piperidine; tetrakis(triphenylphosphine) palladium(0); triphenylphosphine; copper(I) bromide; lithium bromide In tetrahydrofuran for 0.5h; Heating;	94%
With copper(l) iodide; diisopropylamine; triphenylphosphine; palladium dichloride In N,N-dimethyl-formamide at 60℃; for 24h;	78%

2-Bromofluorobenzene Consensus Reports

Reported in EPA TSCA Inventory.

2-Bromofluorobenzene Specification

The 1-Fluoro-2-bromobenzene, with the CAS registry number 1072-85-1 and EINECS registry number 214-018-3, is also called 2-Bromofluorobenzene. It is a kind of clear colourless to light yellow liquid, and belongs to the following product categories: Aromatic Hydrocarbons (substituted) & Derivatives; Fluorobenzene; Bromine Compounds; Fluorine Compounds; Aryl; C6; Halogenated Hydrocarbons. And the molecular formula of this chemical is C₆H₄BrF. What's more, it is used as the intermediate of medicine, pesticide and liquid crystal.

The physical properties of 1-Fluoro-2-bromobenzene are as following: (1)ACD/LogP: 2.96; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 2.95; (4)ACD/LogD (pH 7.4): 2.95; (5)ACD/BCF (pH 5.5): 103.65; (6)ACD/BCF (pH 7.4): 103.65; (7)ACD/KOC (pH 5.5): 964.64; (8)ACD/KOC (pH 7.4): 964.64; (9)#H bond acceptors: 0; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 0; (12)Polar Surface Area: Å²; (13)Index of Refraction: 1.53; (14)Molar Refractivity: 33.93 cm³; (15)Molar Volume: 109.8 cm³; (16)Polarizability: 13.45×10^-24cm³; (17)Surface Tension: 33.8 dyne/cm; (18)Density: 1.593 g/cm³; (19)Flash Point: 50.2 °C; (20)Enthalpy of Vaporization: 37.23 kJ/mol; (21)Boiling Point: 151.5 °C at 760 mmHg; (22)Vapour Pressure: 4.67 mmHg at 25°C.

Uses of 1-Fluoro-2-bromobenzene: It can react with cyclopenta-1,3-diene to produce 1,4-dihydro-1,4-methano-naphthalene. This reaction will need reagent Mg, and solvent diethyl ether. The reaction time is 3 hours with the temperature of 20°C, and the yield is about 66%.

1-Fluoro-2-bromobenzene can react with cyclopenta-1,3-diene to produce 1,4-dihydro-1,4-methano-naphthalene

You should be cautious while dealing with this chemical. It is a kind of flammale chemical which irritates eyes, respiratory system and skin, and also harmful by inhalation, in contact with skin and if swallowed. Therefore, you had better take the following instructions: Wear suitable protective clothing, gloves and eye/face protection, and in case of contacting with eyes, rinse immediately with plenty of water and seek medical advice; Keep away from sources of ignition - No smoking.

You can still convert the following datas into molecular structure:
(1)SMILES: Fc1ccccc1Br
(2)InChI: InChI=1/C6H4BrF/c7-5-3-1-2-4-6(5)8/h1-4H
(3)InChIKey: IPWBFGUBXWMIPR-UHFFFAOYAA

Product Name

2-Bromofluorobenzene

Synthetic route

2-Bromofluorobenzene Consensus Reports

2-Bromofluorobenzene Specification

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