2-Chlorobenzoic acid supplier

Name
o-Chlorobenzoic acid
EINECS 204-285-4
CAS No. 118-91-2
Article Data332
CAS DataBase
Density 1.544 g/cm³
Solubility soluble in hot water
Melting Point 139-143 °C
Formula C₇H₅ClO₂
Boiling Point 275.7 °C at 760 mmHg
Molecular Weight 156.569
Flash Point 120.5 °C
Transport Information
Appearance white crystals or powder
Safety 26-37/39
Risk Codes 36-36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms 2-CBA;o-Chlorobenzoic acid;Benzoic acid, 2-chloro-;Benzoic acid, o-chloro-;Kyselina o-chlorbenzoova;O-chloro-benzoic acid;2 - Chloro Benzoic Acid;O-Chloro benzoic acid;2-chloro benzoic acid;2 Chloro Benzoic Acid;Ortho chlorobenzoic acid;Ortho-chloro benzoic acid;
PSA 37.30000
LogP 2.03820

Synthetic route

: 89-98-5
2-chloro-benzaldehyde

: 118-91-2
ortho-chlorobenzoic acid

Conditions

Conditions	Yield
With sodium perborate In acetic acid for 1.5h; steam bath;	100%
With sodium chlorite; dimethyl sulfoxide In water; acetonitrile at 10℃; for 1h;	98%
With selenium(IV) oxide; dihydrogen peroxide In tetrahydrofuran for 9h; Heating;	97%

: 610-96-8
methyl chlorobenzoate

: 118-91-2
ortho-chlorobenzoic acid

Conditions

Conditions	Yield
With sodium; diphenyldisulfane In 1-methyl-pyrrolidin-2-one at 90℃; for 0.25h;	100%
With iodine; aluminium In acetonitrile at 80℃; for 18h;	98%
With potassium hydroxide In toluene at 150℃; for 0.166667h; microwave irradiation;	97%

: 17849-38-6
2-Chlorobenzyl alcohol

: 118-91-2
ortho-chlorobenzoic acid

Conditions

Conditions	Yield
With NH-pyrazole; sodium hydride In tetrahydrofuran for 20h; Ambient temperature;	100%
With Oxone; potassium bromide In water; acetonitrile at 20℃; for 24h; Reagent/catalyst; Solvent;	99%
With sodium hydroxide; sodium periodate; trans-Na6 In water for 1.5h;	96%

: 5328-80-3
2-chlorobenzaldehyde N-[(2-chlorophenyl)methylidene]hydrazone

: 118-91-2
ortho-chlorobenzoic acid

Conditions

Conditions	Yield
With poly(diselanediyl-1,2-phenylene); dihydrogen peroxide In tetrahydrofuran for 140h; Heating;	98%
With [bis(acetoxy)iodo]benzene In tetrahydrofuran at 20℃; for 4h; Green chemistry;	76%

: 107135-19-3
N’-(2-chlorobenzylidene)-4-methylbenzenesulfonohydrazide

: 118-91-2
ortho-chlorobenzoic acid

Conditions

Conditions	Yield
With poly(diselanediyl-1,2-phenylene); dihydrogen peroxide In tetrahydrofuran for 85h; Heating;	98%

: 23975-60-2
1-(2-chlorophenyl)-4,4,4-trifluorobutane-1,3-dione

: 118-91-2
ortho-chlorobenzoic acid

Conditions

Conditions	Yield
With oxygen; sodium hydrogencarbonate In acetonitrile for 4h; Molecular sieve; Irradiation;	98%

: 873-32-5
2-Chlorobenzonitrile

A: 609-66-5
2-chlorobenzamide

B: 118-91-2
ortho-chlorobenzoic acid

Conditions

Conditions	Yield
With potassium hydroxide In toluene at 150℃; for 0.166667h; microwave irradiation;	A 2% B 97%
With phosphate buffer at 30℃; for 6.5h; rhodococcus rhodocrous AJ270, pH 7.0;	A 94% B 4%
With potassium phosphate buffer at 30℃; for 6.5h; Rhodococcus sp. AJ270 cells;	A 94.1% B 4.4%
With potassium hydroxide; cetyltrimethylammonim bromide In toluene at 100℃; for 0.166667h; microwave irradiation;	A 45% B 5%

: 95-49-8
2-methylchlorobenzene

A: 89-98-5
2-chloro-benzaldehyde

B: 611-17-6
1-bromomethyl-2-chlorobenzene

C: 118-91-2
ortho-chlorobenzoic acid

Conditions

Conditions	Yield
With oxygen; cobalt(II) acetate; sodium bromide In acetic acid at 95℃; for 0.666667h; Kinetics; Mechanism; Rate constant; other time; other temperature; various concentrations of Co(OAc)2 and NaBr;	A n/a B n/a C 96%
With oxygen; cobalt(II) acetate; sodium bromide In acetic acid at 95℃; for 0.666667h;	A n/a B n/a C 95%

...Expand

: 1429790-14-6
methyl 3-(2-chlorophenyl)-3-oxopropanedithioate

: 118-91-2
ortho-chlorobenzoic acid

Conditions

Conditions	Yield
With sodium hydroxide In water at 100℃; for 8.5h; Reflux; chemoselective reaction;	96%

: 873-32-5
2-Chlorobenzonitrile

: 118-91-2
ortho-chlorobenzoic acid

Conditions

Conditions	Yield
With benzene-1,2-dicarboxylic acid for 0.833333h; microwave-irradiation;	94%
With phosphate buffer at 30℃; for 168h; rhodococcus rhodocrous AJ270, pH 7.0;	80%
With potassium phosphate buffer at 30℃; for 168h; Rhodococcus sp. AJ270 cells;	79.9%
With sulfuric acid

: 2039-87-4
2-chlorostyrene

: 118-91-2
ortho-chlorobenzoic acid

Conditions

Conditions	Yield
Stage #1: 2-chlorostyrene With tert.-butylhydroperoxide; iron(III) chloride hexahydrate; sodium hydroxide In water at 80℃; for 10h; Stage #2: With hydrogenchloride In water at 20℃;	94%
With Oxone; 2-iodo-3,4,5,6-tetramethylbenzoic acid In water; acetonitrile for 24h;	79%
Stage #1: 2-chlorostyrene With tert.-butylhydroperoxide; iodine; sodium hydroxide In water at 105℃; for 16h; Sealed tube; Stage #2: With hydrogenchloride In water	58%

: 95-49-8
2-methylchlorobenzene

: 118-91-2
ortho-chlorobenzoic acid

Conditions

Conditions	Yield
With ruthenium trichloride; sodium hypochlorite; tetrabutylammomium bromide In 1,2-dichloro-ethane at 25℃; for 2h;	93%
With carbon tetrabromide; oxygen In acetonitrile at 20℃; for 60h; UV-irradiation;	91.5%
With oxygen; Langlois reagent In acetonitrile at 25℃; for 12h; Irradiation; Green chemistry;	91%

: 949-67-7
L-tyrosine ethyl ester

: 609-65-4
o-chlorobenzoyl chloride

A: 797760-44-2
N-(2-chlorobenzoyl)-(L)-tyrosine ethyl ester

B: 118-91-2
ortho-chlorobenzoic acid

Conditions

Conditions	Yield
Stage #1: L-tyrosine ethyl ester With sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; Stage #2: o-chlorobenzoyl chloride In tetrahydrofuran; water at 0 - 20℃; for 0.5h;	A 92% B 5%

...Expand

: 7579-40-0
benzyl 2-chlorobenzoate

: 108-88-3
toluene

A: 620-47-3
1-methyl-3-(phenylmethyl)-benzene

B: 620-83-7
1-methyl-4-(phenylmethyl)benzene

C: 713-36-0
2-benzyltoluene

D: 118-91-2
ortho-chlorobenzoic acid

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate; water at 80℃; for 2h; regioselective reaction;	A n/a B n/a C n/a D 92%

...Expand

: 89-98-5
2-chloro-benzaldehyde

A: 17849-38-6
2-Chlorobenzyl alcohol

B: 118-91-2
ortho-chlorobenzoic acid

Conditions

Conditions	Yield
Stage #1: 2-chloro-benzaldehyde With potassium hydroxide In water at 20℃; Cannizzaro reaction; Stage #2: With hydrogenchloride In water	A 85% B 91%
With sodium hydroxide In water at 20℃; for 2.5h; Cannizzaro Reaction;	A n/a B 90%
Stage #1: 2-chloro-benzaldehyde In neat (no solvent) for 0.0333333h; Green chemistry; Stage #2: With 1,4-diaza-bicyclo[2.2.2]octane In neat (no solvent) at 40℃; for 0.00833333h; Reagent/catalyst; Cannizzaro Reaction; Microwave irradiation; Green chemistry;

: 3717-28-0
2-chloro benzaldehyde oxime

: 118-91-2
ortho-chlorobenzoic acid

Conditions

Conditions	Yield
With poly(diselanediyl-1,2-phenylene); dihydrogen peroxide In tetrahydrofuran for 63h; Heating;	90%

: 32345-65-6, 133082-13-0, 59365-60-5
(DL)-o-chlorophenyl-1,2-ethanediol

: 118-91-2
ortho-chlorobenzoic acid

Conditions

Conditions	Yield
With tert.-butylhydroperoxide; potassium tert-butylate In water at 80℃; for 8h;	90%

: 201230-82-2
carbon monoxide

: 615-41-8
2-iodochlorobenzene

: 118-91-2
ortho-chlorobenzoic acid

Conditions

Conditions	Yield
With water; palladium diacetate; triethylamine; triphenylphosphine In 1,4-dioxane at 110℃; under 11251.1 Torr; for 2h; Reagent/catalyst; Temperature; Pressure; Flow reactor;	90%
Stage #1: carbon monoxide; 2-iodochlorobenzene With potassium carbonate In water at 100℃; under 3750.38 Torr; for 12h; Autoclave; Stage #2: With hydrogenchloride In water	85%
With water; potassium carbonate In acetonitrile at 100℃; under 3750.38 Torr; for 0.0161111h;	74%

: 70657-63-5
2-chloro-N,N-diisopropylbenzamide

A: 6291-28-7
3-chlorobenzoic acid isopropylamide

B: 118-91-2
ortho-chlorobenzoic acid

Conditions

Conditions	Yield
With hydrogenchloride; zinc(II) chloride at 160℃; for 72h;	A 9% B 89%

: 124-38-9
carbon dioxide

: 346656-42-6
2-(2-chlorophenyl)-5,5-dimethyl-1,3,2-dioxaborinane

: 118-91-2
ortho-chlorobenzoic acid

Conditions

Conditions	Yield
Stage #1: carbon dioxide; 2-(2-chlorophenyl)-5,5-dimethyl-1,3,2-dioxaborinane With potassium tert-butylate; silver(I) acetate; triphenylphosphine In tetrahydrofuran at 70℃; under 15201 Torr; for 16h; Inert atmosphere; Autoclave; Stage #2: With hydrogenchloride In tetrahydrofuran; water Inert atmosphere;	89%

: 110-00-9
furan

: 1608-42-0
benzenedizolium-2-carboxylate

A: 573-57-9
1,4-dihydronaphthalene-1,4-epoxide

B: 579-75-9
2-Methoxybenzoic acid

C: 118-91-2
ortho-chlorobenzoic acid

Conditions

Conditions	Yield
With 1,2-dichloro-ethane at 80℃; for 2h; Product distribution; Mechanism; acids were detected as methyl esters (methylated by CH2N2);	A 88% B n/a C n/a

...Expand

: 89-97-4
2-CHLOROBENZYLAMINE

: 118-91-2
ortho-chlorobenzoic acid

Conditions

Conditions	Yield
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; laccasefrom Trametes versicolor; oxygen In water at 30℃; for 240h; pH=4.5; Enzymatic reaction;	88%

: 13524-04-4
2'-chloro-sec-phenethyl alcohol

A: 89-98-5
2-chloro-benzaldehyde

B: 118-91-2
ortho-chlorobenzoic acid

Conditions

Conditions	Yield
With sodium nitrate; water; oxygen In dimethyl sulfoxide at 130℃; for 36h;	A 9% B 87%

: 110-00-9
furan

: 1608-42-0
benzenedizolium-2-carboxylate

A: 573-57-9
1,4-dihydronaphthalene-1,4-epoxide

B: 108-90-7
chlorobenzene

C: 118-91-2
ortho-chlorobenzoic acid

Conditions

Conditions	Yield
With triethylamine hydrochloride In chloroform at 60℃; for 48h; Product distribution; Mechanism; var. temp.: RT; acid was identified as methyl ester (methylated by CH2N2);	A 85% B 6% C 15%

...Expand

: 16537-16-9
2-chloro-benzoic acid tert-butyl ester

: 118-91-2
ortho-chlorobenzoic acid

Conditions

Conditions	Yield
With water; iodine In acetonitrile for 4h; Heating;	85%

: 118-92-3
anthranilic acid

: 118-91-2
ortho-chlorobenzoic acid

Conditions

Conditions	Yield
Stage #1: anthranilic acid With hydrogenchloride; sodium nitrite In water at 6 - 8℃; for 0.416667h; Stage #2: With aluminum sulfate; potassium chloride; copper(II) sulfate In water for 1 - 1.5h;	84%
With hydrogenchloride; water; sodium nitrite man giesst dann in eine Loesung von CuCl;
With tert.-butylnitrite; copper dichloride In acetonitrile

: 2-Chloro-benzoic acid 3-methyl-but-2-enyl ester

: 118-91-2
ortho-chlorobenzoic acid

Conditions

Conditions	Yield
With iodine In cyclohexane for 6h; Ambient temperature;	84%

: 7579-40-0
benzyl 2-chlorobenzoate

: 118-91-2
ortho-chlorobenzoic acid

Conditions

Conditions	Yield
With methanol; sodium tetrahydroborate; nickel(II) chloride hexahydrate at 20℃; for 0.0833333h; chemoselective reaction;	83%

: 2444-36-2
2'-chloro-benzeneacetic acid

: 118-91-2
ortho-chlorobenzoic acid

Conditions

Conditions	Yield
With iodine; dimethyl sulfoxide at 120℃; for 25h; Sealed tube; Green chemistry;	83%

: 67-56-1
methanol

: 118-91-2
ortho-chlorobenzoic acid

: 610-96-8
methyl chlorobenzoate

Conditions

Conditions	Yield
With sulfuric acid for 4h; Reflux;	100%
With sulfuric acid Heating;	99%
With 1,3,5-trichloro-2,4,6-triazine; sodium carbonate at 50℃; for 0.333333h; Sonication;	94%

: 118-91-2
ortho-chlorobenzoic acid

: 609-65-4
o-chlorobenzoyl chloride

Conditions

Conditions	Yield
With thionyl chloride In toluene at 75℃;	100%
With thionyl chloride Reflux;	100%
With thionyl chloride at 100℃;	100%

: 118-91-2
ortho-chlorobenzoic acid

: 65-85-0
benzoic acid

Conditions

Conditions	Yield
With hydrogen; triethylamine; palladium on activated charcoal In methanol at 20℃; for 3h;	100%
With borane-ammonia complex In water; isopropyl alcohol at 40℃; for 3h; Sealed tube;	97%
With 1H-imidazole; copper ammonium sulphate hexahydrate; lithium tert-butoxide In N,N-dimethyl-formamide; isopropyl alcohol for 72h; Irradiation;	87%

: 3518-83-0
1-ethylpiperidin-4-ol

: 118-91-2
ortho-chlorobenzoic acid

: 2-chloro-benzoic acid 1-ethyl-piperidin-4-yl ester

Conditions

Conditions	Yield
With pyridine; p-toluenesulfonyl chloride at 0 - 20℃; Esterification;	100%

: 118-91-2
ortho-chlorobenzoic acid

: 2492-02-6
2,5-bis-(2-chlorophenyl)-1,3,4-oxadiazole

Conditions

Conditions	Yield
With hydrazine dihydrochloride; phosphoric acid; trichlorophosphate In water at 140℃; for 2h; Condensation;	99.2%
With hydrazine dihydrochloride; phosphoric acid; phosphorus pentoxide at 130℃; for 0.0833333h; microwave irradiation;	96%
With sodium tetrahydroborate; hydrazine dihydrochloride; phosphoric acid at 170 - 180℃; for 6h; Inert atmosphere; Neat (no solvent);	87%
With Montmorillonite K10 clay; hydrazine hydrate In ethanol for 0.05h; microwave irradiation;	86%
Multi-step reaction with 3 steps 1: sulfuric acid / 70 - 80 °C 2: hydrazine hydrate / ethanol / 60 - 70 °C 3: trichlorophosphate / 8 h View Scheme

: 64-17-5
ethanol

: 118-91-2
ortho-chlorobenzoic acid

: 7335-25-3
ethyl 2-chlorobenzoate

Conditions

Conditions	Yield
With fluorosulfonyl fluoride; N-ethyl-N,N-diisopropylamine In 1,2-dichloro-ethane at 20℃; for 5h;	99%
With sulfuric acid at 100℃; for 12h; Sealed tube;	95%
With thionyl chloride for 2h; Heating;	86%

: 108-42-9
3-chloro-aniline

: 118-91-2
ortho-chlorobenzoic acid

: 13278-36-9
N-(3-chlorophenyl)anthranilic acid

Conditions

Conditions	Yield
With copper(I) oxide; copper; potassium carbonate In 2-ethoxy-ethanol at 130℃; for 24h;	99%
With pyridine; copper; potassium carbonate In water for 1h; Heating;	60%
With copper; potassium carbonate for 5h; Heating;	44%

: 100-39-0
benzyl bromide

: 118-91-2
ortho-chlorobenzoic acid

: 7579-40-0
benzyl 2-chlorobenzoate

Conditions

Conditions	Yield
With N(Et)4(1+)*(2-pyrrolidone-anion) In N,N-dimethyl-formamide for 1h; Ambient temperature;	99%

: 100-46-9
benzylamine

: 118-91-2
ortho-chlorobenzoic acid

: 6622-55-5
N-benzylanthranilic acid

Conditions

Conditions	Yield
With copper(I) oxide; copper; potassium carbonate In various solvent(s) at 130℃; for 24h;	99%
With potassium hydroxide; copper(II) oxide; tetrabutylammomium bromide In water at 130℃; for 0.0833333h; Ullmann-type C-N coupling; microwave irradiation;	55%
With potassium phosphate; ethylene glycol; copper(l) iodide In butan-1-ol at 100℃; for 72h;	48%
With copper; potassium carbonate In pentan-1-ol at 140℃; for 4h;	44%

: 118-91-2
ortho-chlorobenzoic acid

: 783325-73-5
3-amino-3',5'-dimethylbiphenyl

: 783325-75-7
N-[3-(3,5-dimethylphenyl)phenyl]anthranilic acid

Conditions

Conditions	Yield
With copper(I) oxide; copper; potassium carbonate In 2-ethoxy-ethanol at 130℃; for 24h;	99%
With copper(I) oxide; potassium carbonate; copper(II) oxide In 2-methoxy-ethanol for 2h; Heating;	95%
With copper(I) oxide; copper; potassium carbonate In ethyl methyl ether for 2h; Heating / reflux;	95%

: 100-41-4
ethylbenzene

: 118-91-2
ortho-chlorobenzoic acid

: 111021-09-1
1-phenylethyl 2-chlorobenzoate

Conditions

Conditions	Yield
With tetra-(n-butyl)ammonium iodide In water at 80℃; for 8h;	99%

: 68820-12-2
cyclohexyl-N-tosyl aziridine

: 118-91-2
ortho-chlorobenzoic acid

: 2-((4-methylphenyl)sulfonamido)cyclohexyl 2-chlorobenzoate

Conditions

Conditions	Yield
With tetrabutylammomium bromide In N,N-dimethyl-formamide at 65℃; for 33h; stereoselective reaction;	99%
In N,N-dimethyl-formamide at 65℃; for 43h;	97%
With 1,8-diazabicyclo[5.4.0]undec-7-ene In tetrahydrofuran at 50℃; Green chemistry;	93%

: 1440525-63-2
(1S,2S,4S,5R,6S)-di-tert-butyl 4-amino-2-[(tert-butoxycarbonyl)amino]bicyclo[3.1.0]hexane-2,6-dicarboxylate

: 118-91-2
ortho-chlorobenzoic acid

: di-tert-butyl (1S,2S,4S,5R,6S) 2-((tert-butoxycarbonyl)amino)-4-[(2-chlorobenzoyl)amino]bicyclo[3.1.0]hexane-2,6-dicarboxylate

Conditions

Conditions	Yield
Stage #1: ortho-chlorobenzoic acid With benzotriazol-1-ol; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide Stage #2: (1S,2S,4S,5R,6S)-di-tert-butyl 4-amino-2-[(tert-butoxycarbonyl)amino]bicyclo[3.1.0]hexane-2,6-dicarboxylate In N,N-dimethyl-formamide	99%

: 62-53-3
aniline

: 118-91-2
ortho-chlorobenzoic acid

: 2989-99-3
N-(2-chlorophenyl)-N'-phenylurea

Conditions

Conditions	Yield
With diphenyl phosphoryl azide; triethylamine In toluene at 100℃; for 0.0166667h; Curtius Rearrangement; Microwave irradiation;	99%

: 2113-51-1
2-iodobiphenyl

: 118-91-2
ortho-chlorobenzoic acid

: 217-59-4
triphenylene

Conditions

Conditions	Yield
With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; p-benzoquinone In dimethyl sulfoxide at 140℃; for 4h; Schlenk technique; Inert atmosphere;	99%

: 108-44-1
1-amino-3-methylbenzene

: 118-91-2
ortho-chlorobenzoic acid

: 16524-22-4
2-(m-tolylamino)benzoic acid

Conditions

Conditions	Yield
With copper; caesium carbonate; copper(II) oxide In water at 105℃; Reagent/catalyst; Temperature; Large scale;	98.3%
With copper(I) oxide; copper; potassium carbonate In 2-ethoxy-ethanol at 130℃; for 24h;	80%
With potassium carbonate; copper In N,N-dimethyl-formamide for 2h; Heating;	63%

: 106-49-0
p-toluidine

: 118-91-2
ortho-chlorobenzoic acid

: 16524-23-5
N-p-tolyl-anthranilic acid

Conditions

Conditions	Yield
With copper; potassium carbonate for 5h; Heating;	98%
With copper; sodium carbonate; copper(II) oxide In water at 105℃; Large scale;	97.9%
With pyridine; copper; potassium carbonate In pentan-1-ol for 1h; Heating;	84%

: 62-53-3
aniline

: 118-91-2
ortho-chlorobenzoic acid

: 91-40-7
2-(phenylamino)benzoic acid

Conditions

Conditions	Yield
With copper(I) sulfate; potassium carbonate; copper(II) sulfate In water for 0.0833333h; Ullmann condensation; microwave irradiation;	98%
With potassium carbonate; copper(II) sulfate for 0.025h; Ullmann condensation; microwave irradiation;	98%
With sodium acetate; copper (I) acetate In water for 4h; Heating;	91%

: 118-91-2
ortho-chlorobenzoic acid

: 71-36-3
butan-1-ol

: 52468-48-1
butyl 2-chlorobenzoate

Conditions

Conditions	Yield
With sulfuric acid; acetonitrile at 80 - 85℃; for 16 - 18h;	98%
With thionyl chloride for 2h; Heating;	81%
With sulfuric acid

: 150-13-0
4-amino-benzoic acid

: 118-91-2
ortho-chlorobenzoic acid

: 17332-57-9
N-(4-carboxyphenyl)anthranilic acid

Conditions

Conditions	Yield
With copper(I) oxide; copper; potassium carbonate In 2-ethoxy-ethanol at 130℃; for 24h;	98%
With copper; potassium carbonate In i-Amyl alcohol at 160℃; Ullmann Condensation;	91%
With copper; potassium carbonate In N,N-dimethyl-formamide at 140 - 145℃; for 3.5h;	79%

: 4389-45-1
3-methylantranilic acid

: 118-91-2
ortho-chlorobenzoic acid

: 80841-45-8
2-<(2-carboxyphenyl)amino>-3-methylbenzoic acid

Conditions

Conditions	Yield
With copper; potassium carbonate; copper(I) bromide In various solvent(s) at 160℃; for 0.5h;	98%

: 118-91-2
ortho-chlorobenzoic acid

: 4551-39-7
2-deuteriobenzoic acid

Conditions

Conditions	Yield
With hydrogen; water-d2; triethylamine; palladium on activated charcoal at 20℃;	98%
With 10% Pd/C; hydrogen; water-d2; triethylamine In methanol at 20℃; for 24h; chemoselective reaction;	97%
With deuteriated sodium hydroxide; aluminum nickel In water-d2 at 40℃; for 1h; Yield given;

: 75-03-6
ethyl iodide

: 118-91-2
ortho-chlorobenzoic acid

: 7335-25-3
ethyl 2-chlorobenzoate

Conditions

Conditions	Yield
With caesium carbonate In acetonitrile for 1.5h; Heating;	98%

: 118-91-2
ortho-chlorobenzoic acid

: 13420-63-8
2-chloro-6-iodobenzoic acid

Conditions

Conditions	Yield
With N-iodo-succinimide; [Ir(III)(η5-pentamethylcyclopentadienyl)(H2O)3](SO4) at 60℃; for 16h;	98%
With [bis(acetoxy)iodo]benzene; iodine; palladium diacetate In N,N-dimethyl-formamide at 100℃; for 24h; Sealed tube;	91%
With [bis(acetoxy)iodo]benzene; iodine; palladium diacetate In N,N-dimethyl-formamide at 100℃; for 24h;	87%
Stage #1: ortho-chlorobenzoic acid With (E)-N,N,N′,N′-tetramethylethene-1,2-diamine; sec.-butyllithium In tetrahydrofuran at -78℃; for 0.5h; Stage #2: With iodine In tetrahydrofuran at -78 - 0℃;	53%

: 1468-95-7
9-hydroxymethylanthracene

: 118-91-2
ortho-chlorobenzoic acid

: 2-chloro-benzoic acid anthracen-9-ylmethyl ester

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃;	98%

2-Chlorobenzoic acid Chemical Properties

IUPAC Name: 2-Chlorobenzoic acid
Empirical Formula: C₇H₅ClO₂
Molecular Weight: 156.5664
Canonical SMILES: C1=CC=C(C(=C1)C(=O)O)Cl
InChI: InChI=1S/C7H5ClO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,(H,9,10)
InChIKey: IKCLCGXPQILATA-UHFFFAOYSA-N
EINECS: 204-285-4
Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts; Organics; Highly Purified Reagents; Other Categories; Zone Refined Products; C7; Carbonyl Compounds; Carboxylic Acids; Alpha sort; C; CAlphabetic; CH; Pesticides&Metabolites
Water Solubility: soluble in hot water
Stability: Stable, combustible. Incompatible with strong bases, strong oxidizing agents.
Index of Refraction: 1.583
Molar Refractivity: 38.07 cm³
Molar Volume: 113.9 cm³
Surface Tension: 51.5 dyne/cm
Density: 1.374 g/cm³
Flash Point: 120.5 °C
Enthalpy of Vaporization: 54.31 kJ/mol
Boiling Point: 275.7 °C at 760 mmHg
Vapour Pressure: 0.00242 mmHg at 25 °C
Appearance: white crystals or powder
Melting Point: 138-140 °C(lit.)
Classification Code of 2-Chlorobenzoic acid (CAS NO.118-91-2): Skin / Eye Irritant

2-Chlorobenzoic acid Uses

2-Chlorobenzoic acid is a simple organic compound which can be used as a chemical building block. It may be synthesized by the oxidation of 2-chlorotoluene with potassium permanganate. It can be used as dye intermediate,preservatives of glue and paint, also can be used in the manufacture of pharmaceutical and fungicides.

2-Chlorobenzoic acid Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
rat	LD	oral	> 500mg/kg (500mg/kg)		National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. Vol. 5, Pg. 18, 1953.
rat	LD50	intraperitoneal	2300mg/kg (2300mg/kg)		Bollettino Chimico Farmaceutico. Vol. 112, Pg. 53, 1973.

2-Chlorobenzoic acid Consensus Reports

Reported in EPA TSCA Inventory.

2-Chlorobenzoic acid Safety Profile

Moderately toxic by intraperitoneal route. Mildly toxic by ingestion. An eye and skin irritant. When heated to decomposition it emits toxic fumes of Cl⁻.
Hazard Codes: Xi
Risk Statements: 36-36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
R36:Irritating to eyes.
Safety Statements: 26-37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S37/39:Wear suitable gloves and eye/face protection.
WGK Germany: 2
RTECS: DG4976000
Hazard Note: Irritant

2-Chlorobenzoic acid Specification

2-Chlorobenzoic acid (CAS NO.118-91-2), its Synonyms are Benzoic acid, 2-chloro- ; Benzoic acid, o-chloro- ; Kyselina o-chlorbenzoova ; o-Chlorobenzoic acid .

Product Name

o-Chlorobenzoic acid

Synthetic route

2-Chlorobenzoic acid Chemical Properties

2-Chlorobenzoic acid Uses

2-Chlorobenzoic acid Toxicity Data With Reference

2-Chlorobenzoic acid Consensus Reports

2-Chlorobenzoic acid Safety Profile

2-Chlorobenzoic acid Specification

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