4-Iodoaniline supplier | CasNO.540-37-4

Name
4-Iodoaniline
EINECS 208-743-4
CAS No. 540-37-4
Article Data298
CAS DataBase
Density 1.924 g/cm³
Solubility Slightly soluble in water.Soluble in chloroform, methanol.
Melting Point 61-63 °C(lit.)
Formula C₆H₆IN
Boiling Point 268.7 °C at 760 mmHg
Molecular Weight 219.025
Flash Point 116.3 °C
Transport Information UN 2811
Appearance beige to greyish-brown crystalline powder
Safety 26-36/37/39-36
Risk Codes 22-36/37/38-20/21/22
Molecular Structure
Hazard Symbols Xn, Xi
Synonyms Aniline,p-iodo- (6CI,8CI);1-Iodo-4-aminobenzene;4-Iodobenzenamine;4-Iodobenzeneamine;4-Iodophenylamine;NSC 9246;p-Aminoiodobenzene;p-Aminophenyl iodide;p-Iodoaniline;4-Iodo-phenylamine;4-Iodoaniline;
PSA 26.02000
LogP 2.45460

Synthetic route

: 636-98-6
p-nitrobenzene iodide

: 540-37-4
p-aminoiodobenzene

Conditions

Conditions	Yield
With hydrazine hydrate In methanol at 26℃; for 0.166667h; Reagent/catalyst; Solvent;	100%
With cadmium sulphide; ammonium formate In water at 20℃; for 20h; Inert atmosphere; Irradiation; Sealed tube;	100%
With magnesium; nickel dichloride In water at 20℃; for 12h; Sealed tube; Photolysis; Inert atmosphere;	100%

: 1059625-65-8
4-aminobenzenediazonium 4-methylbenzenesulfonate

: 540-37-4
p-aminoiodobenzene

Conditions

Conditions	Yield
With potassium iodide In water at 20℃; for 0.833333h;	100%

: 62-53-3
aniline

: 540-37-4
p-aminoiodobenzene

Conditions

Conditions	Yield
With tetramethylammonium dibromoiodate(I) at 20℃; for 0.0833333h;	99%
With iodine at 30℃; for 12h; Reagent/catalyst; Solvent; Green chemistry; regioselective reaction;	97%
With sulfuric acid; dihydrogen peroxide; potassium iodide In methanol at 20℃; for 4h;	96%

: 106-50-3
1,4-phenylenediamine

: 540-37-4
p-aminoiodobenzene

Conditions

Conditions	Yield
Stage #1: 1,4-phenylenediamine With toluene-4-sulfonic acid In water at 20℃; Stage #2: With potassium iodide In water at 20℃; for 1.5h;	98%

: 53694-87-4
1-azido-4-iodo-benzene

: 540-37-4
p-aminoiodobenzene

Conditions

Conditions	Yield
With hydrazine hydrate In ethanol at 20℃; chemoselective reaction;	96%
With methanol; samarium; iodine for 6h; Ambient temperature;	91%
Stage #1: 1-azido-4-iodo-benzene With hydrazine hydrate for 0.166667h; Inert atmosphere; Stage #2: for 12h; Irradiation; chemoselective reaction;	90%

: 1601-97-4, 21650-53-3
bis-(4-iodo-phenyl)-diazene

: 540-37-4
p-aminoiodobenzene

Conditions

Conditions	Yield
With polystyrene-CH2-NH3(+)HCO2(-); magnesium In methanol at 20℃; for 0.2h;	96%
With aminomethyl polystyrene resin formic acid salt; zinc In methanol at 20℃; for 0.2h;	95%
With aminomethylpolystyrene-supported formate; palladium on activated charcoal In methanol at 20℃; for 2.5h;	95%
With perchloric acid In isopropyl alcohol; acetonitrile at 25℃; for 0.75h; pH=2; Inert atmosphere; Irradiation;	86%

: 2-oxo-2-phenylethyl (4-iodophenyl)carbamate

: 540-37-4
p-aminoiodobenzene

Conditions

Conditions	Yield
With potassium phosphate; tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate; ascorbic acid In water; acetonitrile at 20℃; for 2.5h; Sealed tube; Irradiation; Inert atmosphere;	93%

: 2,2,2-trichloroethyl (4-iodophenyl)carbamate

: 540-37-4
p-aminoiodobenzene

Conditions

Conditions	Yield
With trimethyltin(IV) hydroxide In 1,2-dichloro-ethane at 60℃; Inert atmosphere; chemoselective reaction;	93%

: 106-40-1
4-bromo-aniline

: 540-37-4
p-aminoiodobenzene

Conditions

Conditions	Yield
With copper(I) oxide; L-proline; potassium iodide In ethanol at 110℃; for 30h; Schlenk technique; Inert atmosphere; Sealed tube;	90%

: 68120-56-9, 104013-25-4, 53207-29-7
1-(4-iodophenyl)ethanol

: 540-37-4
p-aminoiodobenzene

Conditions

Conditions	Yield
With sodium azide; methanesulfonic acid; trifluoroacetic acid In hexane at 40℃; for 4h; Sealed tube;	90%
With sodium azide; methanesulfonic acid; trifluoroacetic acid In hexane at 40℃; for 4h; Reagent/catalyst;	90%

: 62-53-3
aniline

A: 615-43-0
2-iodophenylamine

B: 540-37-4
p-aminoiodobenzene

Conditions

Conditions	Yield
With potassium ferrate(VI); iodine In hexane for 1.5h; Reflux; regioselective reaction;	A n/a B 88%
With hydrogenchloride; potassium iodate; potassium iodide In methanol; water at 20℃;	A n/a B 65%
With N-iodo-succinimide; perchloric acid In acetic acid at 35℃; Kinetics; Mechanism; Thermodynamic data; other temperatures; dependence on the concentrations of substrate; E(activ.), ΔH(excit.), ΔS(excit.);

: 159217-89-7
N-Boc-4-iodoaniline

: 540-37-4
p-aminoiodobenzene

Conditions

Conditions	Yield
With methanol; oxalyl dichloride at 20℃; for 2h;	86%

: 1247414-30-7
2-(4-iodophenoxy)propanamide

: 540-37-4
p-aminoiodobenzene

Conditions

Conditions	Yield
With potassium hydroxide In dimethyl sulfoxide at 140℃; for 3h; Green chemistry;	85%
With potassium hydroxide at 140℃;	177.3 mg

: 636-98-6
p-nitrobenzene iodide

A: 13125-93-4
1-iodo-4-nitrosobenzene

B: 540-37-4
p-aminoiodobenzene

Conditions

Conditions	Yield
Stage #1: p-nitrobenzene iodide With ammonium chloride; zinc In 2-methoxy-ethanol at 20℃; for 0.5h; Reduction; Stage #2: With iron(III) chloride In ethanol; water at 0℃; for 3h; Oxidation;	A 82% B n/a

: 636-98-6
p-nitrobenzene iodide

A: 62-53-3
aniline

B: 540-37-4
p-aminoiodobenzene

Conditions

Conditions	Yield
With Rh/Al2O3; hydrogen In water; toluene at 80℃; under 30003 Torr; for 24h; Reagent/catalyst; Pressure; Temperature;	A 22% B 78%
With Rh/Al2O3; hydrogen In water; toluene at 60℃; under 30003 Torr; for 24h; Reagent/catalyst; Pressure; Temperature;	A 60% B 38%
With water; iron at 210℃; for 2h;	A 37 % Chromat. B 52 % Chromat.

: 120-72-9
indole

: 636-98-6
p-nitrobenzene iodide

: 3340-78-1
2-phenyl-1,2,3,4-tetrahydroisoquinoline

A: 1-(1H-indol-3-yl)-2-phenyl-1, 2, 3, 4-tetrahydroisoquinoline

B: 540-37-4
p-aminoiodobenzene

Conditions

Conditions	Yield
With Co(dmgH)2Cl2; Eosin Y In water; acetonitrile at 20℃; for 48h; Inert atmosphere; Irradiation; Sealed tube;	A 78% B 85 %Spectr.

...Expand

: 5122-99-6
4-iodophenylboronic acid

: 540-37-4
p-aminoiodobenzene

Conditions

Conditions	Yield
With sodium hydroxide; hydroxylamine-O-sulfonic acid In acetonitrile at 20℃; for 16h;	74%
With O-(2,4-dinitrophenyl)hydroxylamine In 1,4-dioxane at 50℃; for 24h; Inert atmosphere;	60%
With copper(I) oxide; ammonium hydroxide In water for 0.0833333h; Microwave irradiation;

: 2351-50-0
4-iodostyrene

: 540-37-4
p-aminoiodobenzene

Conditions

Conditions	Yield
With methanesulfonic acid; trimethylsilylazide In tetrachloromethane at 80℃; for 4h;	69%

: 60577-34-6
p-iodo-N-methylaniline

: 540-37-4
p-aminoiodobenzene

Conditions

Conditions	Yield
With piperidine; dichloro(dimethylglyoxime)(dimethylglyoximato)cobalt(III); (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate In acetonitrile at -78℃; for 40h; Reagent/catalyst; Sealed tube; Inert atmosphere; Irradiation;	65%

: 17356-09-1
4-iodocumene

: 540-37-4
p-aminoiodobenzene

Conditions

Conditions	Yield
With sodium azide; oxygen; trifluoroacetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone at 40℃; for 4h; Sealed tube;	61%
With sodium azide; trifluoroacetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone at 40℃; for 4h;	61%

: 51218-04-3
C15H12I2N2

A: 51218-00-9
β-(p-Jodanilino)acrolein

B: 540-37-4
p-aminoiodobenzene

Conditions

Conditions	Yield
With water; sodium acetate; acetic acid In ethanol; acetone; benzene at 70℃; for 49.5h;	A 36% B 55%

: 62-53-3
aniline

A: 533-70-0
2,4-diiodoaniline

B: 540-37-4
p-aminoiodobenzene

Conditions

Conditions	Yield
With ammonium peroxydisulfate; potassium iodide In methanol; water at 20℃;	A 8% B 55%
With 1-(2-hydroxy-4-methoxyphenyl)ethanone; iodine In benzene for 36h; Irradiation;
With 1-(2-hydroxy-4-methoxyphenyl)ethanone; iodine In benzene for 36h; Irradiation;
With N-iodo-succinimide; zirconium(IV) chloride In dichloromethane at 0℃; for 2h; Conversion of starting material;
With 1-butyl-3-methyl-pyridinium dichloroiodate for 2h;	A 19 %Chromat. B 80 %Chromat.

: 636-98-6
p-nitrobenzene iodide

A: 92-87-5
p,p'-diaminobiphenyl

B: 540-37-4
p-aminoiodobenzene

Conditions

Conditions	Yield
With hydrazine hydrate In ethanol at 70℃; for 4h; chemoselective reaction;	A 27% B 55%

: 106-47-8
4-chloro-aniline

A: 62-53-3
aniline

B: 540-37-4
p-aminoiodobenzene

Conditions

Conditions	Yield
With triethylamine; sodium iodide In acetonitrile for 2h; Irradiation;	A 5% B 51%

: potassium (4-iodophenyl)trifluoroborate

: 540-37-4
p-aminoiodobenzene

Conditions

Conditions	Yield
With sodium hydroxide; hydroxylamine-O-sulfonic acid In water; acetonitrile for 3h; Sonication;	49%

: 591-50-4
iodobenzene

: 1493-13-6
trifluorormethanesulfonic acid

A: 615-43-0
2-iodophenylamine

B: 144930-55-2
(4-iodophenyl)(phenyl)iodonium trifluoromethanesulfonate

C: 540-37-4
p-aminoiodobenzene

Conditions

Conditions	Yield
Stage #1: trifluorormethanesulfonic acid With xenon difluoride; trimethylsilyl isocyanate In dichloromethane at -78℃; Stage #2: iodobenzene In dichloromethane at -78℃;	A n/a B 44% C n/a

...Expand

: C21H26IN2O4Pol

: 540-37-4
p-aminoiodobenzene

Conditions

Conditions	Yield
With trifluoroacetic acid In dichloromethane at 20℃; for 1h; BAL lantane; Product distribution / selectivity;	38%

: 53694-87-4
1-azido-4-iodo-benzene

: 109-89-7
diethylamine

A: Diethyl-(5-iodo-3H-azepin-2-yl)-amine

B: 540-37-4
p-aminoiodobenzene

Conditions

Conditions	Yield
In cyclohexane Ambient temperature; Irradiation; Title compound not separated from byproducts;	A 34% B 12%

...Expand

: 592-41-6
1-hexene

: 106-47-8
4-chloro-aniline

A: 62-53-3
aniline

B: 540-37-4
p-aminoiodobenzene

C: 4-(2-iodohexyl)aniline

D: 4-(1-(iodomethyl)pentyl)aniline

Conditions

Conditions	Yield
With sodium iodide In acetonitrile ionic Meerwein arylation; Irradiation;	A 3% B 12% C 32% D 10%

...Expand

: 100-52-7
benzaldehyde

: 540-37-4
p-aminoiodobenzene

: 3381-47-3, 102904-39-2
N-benzylidene-4-iodoaniline

Conditions

Conditions	Yield
In ethanol for 1h; Sonication;	100%
In benzene Heating;	83%
In ethanol Heating;	57%

: 98-59-9
p-toluenesulfonyl chloride

: 540-37-4
p-aminoiodobenzene

: 158268-30-5
N-tosyl-4-iodoaniline

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 4℃;	100%
With triethylamine In dichloromethane at 0 - 20℃;	96%
With pyridine at 85℃; for 4h;	87%

: 100-52-7
benzaldehyde

: 98-86-2
acetophenone

: 540-37-4
p-aminoiodobenzene

: 94871-48-4
[3-(phenyl)-3-((4-iodophenyl)amino)-1-phenylpropan-1-one]

Conditions

Conditions	Yield
sodium tetrakis(3,5-trifluoromethylphenyl)borate In water at 30℃; for 24h; Mannich reaction;	100%
With nitrogen and sulfur doped porous carbon catalyst In ethanol at 20℃; for 6.5h;	91%
With hydrogenchloride In ethanol at 10℃; for 10h;	90%

...Expand

: 2258-42-6
Acetic formic anhydride

: 540-37-4
p-aminoiodobenzene

: 6393-17-5
N-(4-iodo-phenyl)-formamide

Conditions

Conditions	Yield
In tetrahydrofuran at -20℃; for 0.25h;	100%
In tetrahydrofuran at 20℃; for 3h; Schlenk technique; Inert atmosphere;	97%
In tetrahydrofuran at 0 - 20℃;

: 128346-30-5
(2-formylphenyl)butyl tellurium dibromide

: 540-37-4
p-aminoiodobenzene

: 130191-26-3
2-(4'-iodophenyliminomethinyl)phenyltellurenyl bromide

Conditions

Conditions	Yield
With trifluoroacetic acid In benzene	100%

: 32315-10-9
bis(trichloromethyl) carbonate

: 540-37-4
p-aminoiodobenzene

: 15845-62-2
1-iodo-4-isocyanatobenzene

Conditions

Conditions	Yield
With triethylamine In dichloromethane	100%
In ethyl acetate for 4h; Heating;	74%
With triethylamine In dichloromethane at -35 - 20℃; for 2h;	60%

: 24424-99-5
di-tert-butyl dicarbonate

: 540-37-4
p-aminoiodobenzene

: 159217-89-7
N-Boc-4-iodoaniline

Conditions

Conditions	Yield
With sodium hydrogencarbonate In tetrahydrofuran at 20℃;	100%
In neat (no solvent) at 80℃; for 0.166667h; Temperature; Green chemistry; chemoselective reaction;	98%
Stage #1: p-aminoiodobenzene With triethylamine In tetrahydrofuran; water at 20℃; for 0.0833333h; Stage #2: di-tert-butyl dicarbonate In tetrahydrofuran; water at 0 - 20℃; for 6h;	97.5%

: 5720-07-0
4-methoxyphenylboronic acid

: 540-37-4
p-aminoiodobenzene

: 1137-77-5
4-(4-methoxyphenyl)aniline

Conditions

Conditions	Yield
With sodium carbonate In ethanol; water at 80℃; for 1h; Suzuki-Miyaura Coupling; Green chemistry;	100%
With potassium carbonate In ethanol at 78℃; for 1h; Suzuki-Miyaura coupling; Air atmosphere;	96%
With potassium carbonate In methanol; water at 40 - 45℃; for 1.5h; Suzuki Coupling;	92%

: 50-00-0
formaldehyd

: 540-37-4
p-aminoiodobenzene

: 698-70-4
4-Iodo-N,N-dimethylaniline

Conditions

Conditions	Yield
With sodium cyanoborohydride In acetic acid	100%
With sodium cyanoborohydride In acetic acid at 20℃; for 12h;	96%
With sodium cyanoborohydride; acetic acid at 22℃; Inert atmosphere; Schlenk technique;	91%

: 110-13-4
2,5-hexanedione

: 540-37-4
p-aminoiodobenzene

: 288608-09-3
1-(2,5-dimethyl-1H-pyrrol-1-yl)-4-iodobenzene

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In toluene Inert atmosphere; Schlenk technique;	100%
With nano-Fe3O4 immoblized lewis acidic ionic liquid In neat (no solvent) at 20℃; for 0.5h; Paal-Knorr Pyrrole Synthesis; Sonication;	98%
With toluene-4-sulfonic acid In toluene for 4h; Inert atmosphere; Reflux;	97%

: 37517-81-0
3-chloro-3-oxopropanoic acid methyl ester

: 540-37-4
p-aminoiodobenzene

: 658709-61-6
methyl 3-((4-iodophenyl)amino)-3-oxopropanoate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃;	100%
With triethylamine In ethyl acetate at 20℃; for 16h; Cooling with acetone-dry ice;	99%
With triethylamine In ethyl acetate at 10 - 15℃; for 0.5h;	29.8 g

: 13790-39-1
6,7-dimethoxy-4-chloroquinazoline

: 540-37-4
p-aminoiodobenzene

: 168835-91-4
11N-070

Conditions

Conditions	Yield
With isopropyl alcohol Heating;	100%
In isopropyl alcohol for 3h; Heating / reflux;	95%

: 540-37-4
p-aminoiodobenzene

: 183322-18-1
4-chloro-6,7-bis(2-methoxyethoxy)quinazoline

: 882511-65-1
[6,7-bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-(4-iodo-phenyl)-amine

Conditions

Conditions	Yield
With isopropyl alcohol Heating;	100%

: 13668-61-6
(cyclopent-2-eneyl)acetic acid

: 540-37-4
p-aminoiodobenzene

: 2-cyclopent-2-enyl-N-(4-iodo-phenyl)-acetamide

Conditions

Conditions	Yield
With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In dichloromethane	100%

: 4530-20-5
BOC-glycine

: 540-37-4
p-aminoiodobenzene

: 216774-64-0
[(4-iodophenylcarbamoyl)methyl]carbamic acid tert-butyl ester

Conditions

Conditions	Yield
With dacarbazine; dmap In dichloromethane	100%
With dmap; diisopropyl-carbodiimide In dichloromethane for 20h; Inert atmosphere;	100%
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃; for 5h;	98%

: 705-28-2
1-ethynyl-3-trifluoromethylbenzene

: 540-37-4
p-aminoiodobenzene

: 869578-08-5
C15H10F3N

Conditions

Conditions	Yield
With copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride In diethylamine at 50℃;	100%

: 122-01-0
4-chloro-benzoyl chloride

: 540-37-4
p-aminoiodobenzene

: 299954-64-6
4-chloro-N-(4-iodo-phenyl)-benzamide

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 20℃; for 4h;	100%
With triethylamine In tetrahydrofuran at 20℃; for 4h;	100%

: 924-44-7
glyoxylic acid ethyl ester

: 540-37-4
p-aminoiodobenzene

: ethyl 2-((4-iodophenyl)imino)acetate

Conditions

Conditions	Yield
With magnesium sulfate In toluene at 25℃; for 0.5h;	100%
With sodium sulfate In benzene at 20℃;
With sodium sulfate In toluene at 20℃; for 0.5h; Inert atmosphere;

: 540-37-4
p-aminoiodobenzene

: 13831-31-7
Acetoxyacetyl chloride

: 2-((4-iodophenyl)amino)-2-oxoethyl acetate

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 1.75h;	100%

: 10365-98-7
3-methoxyphenylboronic acid

: 540-37-4
p-aminoiodobenzene

: 207287-79-4
3'-methoxy-[1,1'-biphenyl]-4-amine

Conditions

Conditions	Yield
With potassium carbonate In ethanol at 80℃; for 36h; Suzuki-Miyaura Coupling; Inert atmosphere;	100%
With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate In 1,4-dioxane; water Suzuki Coupling; Inert atmosphere; Reflux;
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In N,N-dimethyl-formamide at 160℃; for 0.5h; Suzuki Coupling; Microwave irradiation;

: 1521-51-3
rac-3-bromocyclohexene

: 540-37-4
p-aminoiodobenzene

: 1619252-25-3
4-bromo-N-(cyclohex-2-en-1-yl)aniline

Conditions

Conditions	Yield
With potassium carbonate In dichloromethane at 20℃; for 12h; Inert atmosphere;	100%

: 16520-62-0
4-Phenyl-1-butyne

: 540-37-4
p-aminoiodobenzene

: 4-(4-phenylbut-1-yn-1-yl)aniline

Conditions

Conditions	Yield
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide for 16h; Reflux; Inert atmosphere;	100%

: 98437-24-2
benzofuran-2-boronic acid

: 540-37-4
p-aminoiodobenzene

: 782-18-3
4-(benzofuran-2-yl)benzenamine

Conditions

Conditions	Yield
With sodium carbonate; dichlorobis(tri-O-tolylphosphine)palladium In 1,2-dimethoxyethane; ethanol; water at 125℃; for 2h;	99.5%

: 403-43-0
4-fluorobenzoyl chloride

: 540-37-4
p-aminoiodobenzene

: 326-03-4
4-fluoro-N-(4-iodophenyl)-benzamide

Conditions

Conditions	Yield
With dmap; triethylamine In tetrahydrofuran at 20℃; for 1h;	99%

: 64-18-6
formic acid

: 540-37-4
p-aminoiodobenzene

: 6393-17-5
N-(4-iodo-phenyl)-formamide

Conditions

Conditions	Yield
With acetic anhydride In tetrahydrofuran; toluene at 15 - 20℃;	99%
With choline chloride*2SnCl2 at 70℃;	92%
With mesoporous silica SBA-15 functionalized with acidic [HNMP]ZnCl3 based deep eutectic solvent In neat (no solvent) at 20℃;	82%

: 540-37-4
p-aminoiodobenzene

: 53694-87-4
1-azido-4-iodo-benzene

Conditions

Conditions	Yield
Stage #1: p-aminoiodobenzene With trifluoroacetic acid; sodium nitrite at 0℃; for 0.5h; Stage #2: With sodium azide In water at 0℃; for 1h;	99%
Stage #1: p-aminoiodobenzene With hydrogenchloride In water at 0℃; Stage #2: With sodium nitrite In water for 0.166667h; Further stages;	98%
Stage #1: p-aminoiodobenzene With sodium nitrite In hydrogenchloride; ethanol at 0℃; for 0.25h; Stage #2: With sodium azide In hydrogenchloride; ethanol at 0℃; for 0.25h; Further stages.;	96%

: 407-25-0
trifluoroacetic anhydride

: 540-37-4
p-aminoiodobenzene

: 126063-08-9
2,2,2-trifluoro-N-(4-iodophenyl)acetamide

Conditions

Conditions	Yield
In tetrahydrofuran for 0.666667h; Ambient temperature;	99%
In tetrahydrofuran at 20℃; for 1h;	98%
In dichloromethane for 1h; Ambient temperature;	78%
With pyridine In dichloromethane at 0℃; for 1h;
In tetrahydrofuran at 0 - 20℃; for 1h;

4-Iodoaniline Consensus Reports

Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.

4-Iodoaniline Specification

4-Iodoaniline appears like White to off-white crystals, and has melting point of 54-56°C. 4-Iodoaniline has a CAS No 540-37-4 and has Molecular Formula C₆H₆NI. Its Molecular weight is 219.04. It is soluble Methanol. It is also called BENZENAMINE, 4-IODO-; 1-amino-4-iodobenzene; P-IODOANILINE; 4-iodo-anilin; 4-iodo-benzenamin; 4-iodobenzenamine; 4-iodo-Benzenamine. 4-Iodoaniline is used in wide range of medicals industrial applocations as well as in human and animal nutrition products such as antiseptics and disinfectants, pharmaceutical intermediates, polarizing films for liquid crystal display [LCD] chemicals. Iodine derivatives are also used as organic building blocks, analytical reagents etc.

Physical properties about 4-Iodoaniline are: (1)ACD/LogP: 2.34; (2)ACD/LogD (pH 5.5): 2.33; (3)ACD/LogD (pH 7.4): 2.34; (4)ACD/BCF (pH 5.5): 34.65; (5)ACD/BCF (pH 7.4): 35.34; (6)ACD/KOC (pH 5.5): 437.74; (7)ACD/KOC (pH 7.4): 446.53; (8)#H bond acceptors: 1; (9)#H bond donors: 2; (10)#Freely Rotating Bonds: 1; (11)Index of Refraction: 1.688; (12)Molar Refractivity: 43.396 cm³; (13)Molar Volume: 113.787 cm³; (14)Polarizability: 17.203 10-24cm³; (15)Surface Tension: 54.185001373291 dyne/cm ; (16)Density: 1.925 g/cm³; (17)Flash Point: 116.295 °C; (18)Enthalpy of Vaporization: 50.677 kJ/mol; (19)Boiling Point: 268.682 °C at 760 mmHg; (20)Vapour Pressure: 0.00800000037997961 mmHg at 25°C

When you are using this chemical, please be cautious about it as the following:
1. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice;
2. Wear suitable protective clothing, gloves and eye/face protection;
3. Wear suitable protective clothing;

You can still convert the following datas into molecular structure:
(1)InChI=1S/C6H6IN/c7-5-1-3-6(8)4-2-5/h1-4H,8H2;
(2)InChIKey=VLVCDUSVTXIWGW-UHFFFAOYSA-N;
(3)Smilesc1(ccc(I)cc1)N;

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Source
bird - wild	LD50	oral	100mg/kg (100mg/kg)	Toxicology and Applied Pharmacology. Vol. 21, Pg. 315, 1972.
rat	LD50	oral	523mg/kg (523mg/kg)	Ceskoslovenska Hygiena. Czechoslovak Hygiene. Vol. 23, Pg. 168, 1978.
rat	LDLo	unreported	500mg/kg (500mg/kg)	British Journal of Pharmacology and Chemotherapy. Vol. 7, Pg. 142, 1952.

Product Name

4-Iodoaniline

Synthetic route

4-Iodoaniline Consensus Reports

4-Iodoaniline Specification

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