4-Iodobiphenyl supplier | CasNO.1591-31-7

Name
4-Iodobiphenyl
EINECS 216-469-1
CAS No. 1591-31-7
Article Data157
CAS DataBase
Density 1.584 g/cm³
Solubility Slightly soluble in water.
Melting Point 110-114 °C
Formula C₁₂H₉I
Boiling Point 322.7 °C at 760 mmHg
Molecular Weight 280.108
Flash Point 145.8 °C
Transport Information UN 3077 9/PG 3
Appearance Off-white crystalline powder
Safety 26-37/39
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi,N,Xn
Synonyms Biphenyl, 4-iodo- (8CI);1, 1-Biphenyl, 4-iodo-;p-Phenyliodobenzene;Biphenyl, 4-iodo-;4-Biphenyl iodide;p-Iodobiphenyl;1,1-Biphenyl, 4-iodo-;1-iodo-4-phenyl-benzene;
PSA 0.00000
LogP 3.95820

Synthetic route

: 92-52-4
biphenyl

: 1591-31-7
4-iodo-biphenyl

Conditions

Conditions	Yield
With dicloroiodoisocyanuric acid In acetonitrile at 20℃; for 2.5h; Darkness; regioselective reaction;	99%
With sulfuric acid; iodine; periodic acid; H-β zeolite In water; acetic acid at 20 - 118℃; for 6h; Heating / reflux;	92%
With tetramethylammonium dibromoiodate(I) at 20℃; for 0.333333h;	90%

: 624-38-4
para-diiodobenzene

: 98-80-6
phenylboronic acid

: 1591-31-7
4-iodo-biphenyl

Conditions

Conditions	Yield
With potassium phosphate In ethanol; water at 28℃; for 24h; Catalytic behavior; Suzuki-Miyaura Coupling; Schlenk technique; Inert atmosphere; Green chemistry;	99%
With 5%-palladium/activated carbon; sodium carbonate In water at 60℃; for 6h; Reagent/catalyst; Temperature;	95%
With sodium hydroxide In ethanol at 25℃; for 1.5h; Suzuki-Miyaura Coupling; Irradiation; Sealed tube; Green chemistry;	92%
With potassium carbonate In water at 90℃; for 5h; Suzuki Coupling; Green chemistry;	91%
With 1,4-diaza-bicyclo[2.2.2]octane; copper(l) iodide; tetrabutylammomium bromide; caesium carbonate In N,N-dimethyl-formamide at 130℃; for 24h; Catalytic behavior; Reagent/catalyst; Suzuki Coupling;	80%

: 5122-94-1
4-biphenylboronic acid

: 1591-31-7
4-iodo-biphenyl

Conditions

Conditions	Yield
With sodium nitrite In acetonitrile at 80℃; for 0.5h; Sealed tube;	99%
With N-iodo-succinimide; potassium acetate In acetonitrile at 50℃; for 4h;	97%
With potassium fluoride; iodine In 1,4-dioxane at 80℃; for 1h;	93%
With perfluoroisopropyl iodide; copper; hydroquinone In N,N-dimethyl-formamide at 20℃; for 24h;	88%
With iodine; potassium carbonate In toluene at 70℃; under 750.075 Torr; for 7h; Inert atmosphere;	50.8%

: 91493-19-5
4-iodoxybiphenyl

: 501-65-5
diphenyl acetylene

A: 1591-31-7
4-iodo-biphenyl

B: 134-81-6
benzil

Conditions

Conditions	Yield
In nitrobenzene at 170℃; for 5h;	A 98% B 34.5%

...Expand

: 1514-50-7
4-iodobenzenediazonium tetrafluoroborate

: 98-80-6
phenylboronic acid

: 1591-31-7
4-iodo-biphenyl

Conditions

Conditions	Yield
With polystyrene-supported-diiodobis(theophylline)palladium(II) complex In methanol at 25℃; for 3h; Suzuki-Miyaura Coupling; chemoselective reaction;	98%
With 5% Pd/BaCO3 In methanol at 25℃; for 12h;	87%
polystyrene-supported N-heterocyclic carbene-Pd complex In ethanol at 20℃; for 12h; Suzuki-Miyaura cross-coupling;	65%

: 4-biphenyldiazonium tetrafluoroborate

: 1591-31-7
4-iodo-biphenyl

Conditions

Conditions	Yield
With trimethylsilyl iodide; methyl iodide In N,N-dimethyl-formamide for 1h; Ambient temperature;	97%

: 92-66-0
4-bromo-1,1'-biphenyl

: 1591-31-7
4-iodo-biphenyl

Conditions

Conditions	Yield
With copper(l) iodide; Trimethylenediamine; sodium iodide In pentan-1-ol at 130℃; for 22h; aromatic Finkelstein reaction;	96%
Stage #1: 4-bromo-1,1'-biphenyl With Trimethylenediamine; sodium iodide; copper(l) iodide In pentan-1-ol at 130℃; for 22h; Stage #2: With ammonia	96%
With copper(l) iodide; trans-N,N'-dimethylcyclohexane-1,2-diamine; sodium iodide In acetonitrile at 100℃; for 1h; Buchwald's halogen exchange reaction; Inert atmosphere; Microwave irradiation;	96%

: 624-38-4
para-diiodobenzene

: 780-69-8
triethoxyphenylsilane

: 1591-31-7
4-iodo-biphenyl

Conditions

Conditions	Yield
With sodium hydroxide In water at 90℃; for 6h; Hiyama Coupling; Green chemistry;	93%
With sodium hydroxide In ethanol at 25℃; for 5h; Hiyama Coupling; Irradiation; Sealed tube; Green chemistry;	88%

: 960-16-7
tributylphenylstannane

: 4-Iodobenzenediazonium o-benzenedisulfonimide

: 1591-31-7
4-iodo-biphenyl

Conditions

Conditions	Yield
palladium diacetate In tetrahydrofuran at 20℃; for 0.5h; Stille reaction;	90%

: potassium biphenyl-4-yltrifluoroborate

: 1591-31-7
4-iodo-biphenyl

Conditions

Conditions	Yield
With 2-iodo-propane; dimethylglyoxal In water at 23℃; for 24h; Inert atmosphere; Schlenk technique; Irradiation; Green chemistry;	90%
With acetic acid; lithium iodide In dimethyl sulfoxide at 100℃; for 8h; Schlenk technique;	71%
With tetra-(n-butyl)ammonium iodide; copper(II) bis(trifluoromethanesulfonate) In acetonitrile at 25℃; for 16h; Sealed tube;	68%
With caesium tribromide In water; N,N-dimethyl-formamide at 80℃; for 6h; chemoselective reaction;	45%

: 780-69-8
triethoxyphenylsilane

: 13116-27-3
4-iodophenylhydrazine

: 1591-31-7
4-iodo-biphenyl

Conditions

Conditions	Yield
With bis(benzonitrile)palladium(II) dichloride; camphor-10-sulfonic acid; tetrabutyl ammonium fluoride In tetrahydrofuran at 50℃; for 3h; Hiyama Coupling;	89%

: 144930-55-2
(4-iodophenyl)(phenyl)iodonium trifluoromethanesulfonate

: 1591-31-7
4-iodo-biphenyl

Conditions

Conditions	Yield
With palladium diacetate at 50℃; for 0.166667h; Microwave irradiation;	89%

: 1514-50-7
4-iodobenzenediazonium tetrafluoroborate

: 8-phenylhexahydro-1,3,2-oxazaborolo[2,3-b]-1,3,2-oxazaborol-4-ium-8-uide

: 1591-31-7
4-iodo-biphenyl

Conditions

Conditions	Yield
With 1% Pd/C In methanol at 50℃; for 0.5h; Suzuki-Miyaura reaction; Inert atmosphere;	88%

: potassium (4-iodophenyl)trifluoroborate

: 59-88-1
phenylhydrazine hydrochloride

: 1591-31-7
4-iodo-biphenyl

Conditions

Conditions	Yield
With diamminedichloropalladium(II); copper(II) choride dihydrate; potassium carbonate In water at 25℃; for 12h; Suzuki Coupling; Green chemistry;	88%

: 92-52-4
biphenyl

A: 1591-31-7
4-iodo-biphenyl

B: 3001-15-8
4,4'-diiodobiphenyl

Conditions

Conditions	Yield
With [bis(acetoxy)iodo]benzene; iodine In ethyl acetate at 60℃; for 16h;	A 12% B 87%
With [bis(acetoxy)iodo]benzene; iodine In ethyl acetate at 60℃; for 16h; Iodination;	A 12% B 87%
With poly; iodine In ethyl acetate at 60℃; for 16h;	A 43% B 2%

: 3958-47-2
triphenylindium

: 4-Iodobenzenediazonium o-benzenedisulfonimide

A: 92-52-4
biphenyl

B: 21650-47-5
(E)-1-(4-iodophenyl)-2-phenyldiazene

C: 1591-31-7
4-iodo-biphenyl

Conditions

Conditions	Yield
bis-triphenylphosphine-palladium(II) chloride In tetrahydrofuran at 20℃; for 0.0833333h;	A 6% B 3% C 85%

...Expand

: 2751-27-1
4-iodobenzenesulfonyl hydrazide

: 98-80-6
phenylboronic acid

: 1591-31-7
4-iodo-biphenyl

Conditions

Conditions	Yield
With palladium diacetate; potassium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In tert-butyl methyl ether at 60℃; for 6h; Suzuki Coupling;	84%

: potassium (4-iodophenyl)trifluoroborate

: 98-09-9
benzenesulfonyl chloride

: 1591-31-7
4-iodo-biphenyl

Conditions

Conditions	Yield
With 1,3-bis-(diphenylphosphino)propane; potassium acetate; palladium dichloride In dimethyl sulfoxide at 60℃; for 6h; Suzuki-Miyaura Coupling;	83%

: 92-67-1
4-Aminobiphenyl

: 1591-31-7
4-iodo-biphenyl

Conditions

Conditions	Yield
Stage #1: 4-phenylalanine With sulfuric acid; silica gel; sodium nitrite at 20℃; grinding; Neat (no solvent); Stage #2: With water at 20℃; grinding; Neat (no solvent); Stage #3: With potassium iodide at 20℃; for 0.166667h; Sandmeyer reaction; grinding; Neat (no solvent);	82%
With toluene-4-sulfonic acid; potassium iodide; sodium nitrite In acetonitrile at 20℃; for 0.5h;	80%
Stage #1: 4-phenylalanine With nicotinic acid sulfate; sodium nitrite In water at 20℃; for 0.333333h; Grinding; Stage #2: With sodium iodide In water at 20℃;	80%

: 5122-94-1
4-biphenylboronic acid

: 140-29-4
phenylacetonitrile

A: 2920-38-9
4-cyano-1,1'-biphenyl

B: 1591-31-7
4-iodo-biphenyl

Conditions

Conditions	Yield
With tert.-butylhydroperoxide; copper(l) iodide In N,N-dimethyl acetamide; water at 130℃; for 16h; Reagent/catalyst; Solvent; Temperature; Time;	A 82% B 13%
With tert.-butylhydroperoxide; copper(l) iodide In N,N-dimethyl acetamide; water at 130℃; for 4h; Concentration; Time;	A 29% B 61%

...Expand

: 5122-99-6
4-iodophenylboronic acid

: 369-57-3
benzenediazonium tetrafluoroborate

: 1591-31-7
4-iodo-biphenyl

Conditions

Conditions	Yield
With chloro[tris(para-trifluoromethylphenyl)phosphine]gold (I) In methanol at 20℃; Irradiation; Inert atmosphere;	81%

: potassium biphenyl-4-yltriolborate

: 1591-31-7
4-iodo-biphenyl

Conditions

Conditions	Yield
With chloroamine-T; sodium iodide In tetrahydrofuran; water at 20℃; for 0.333333h;	80%

: 624-31-7
4-tolyl iodide

: 71-43-2
benzene

: 1591-31-7
4-iodo-biphenyl

Conditions

Conditions	Yield
With dipotassium peroxodisulfate; silver nitrate In acetonitrile at 120℃; for 20h; Sealed tube; Schlenk technique; Inert atmosphere;	80%

: 18057-71-1
[1,1'-biphenyl-4-yl]triethylsilane

: 1591-31-7
4-iodo-biphenyl

Conditions

Conditions	Yield
With N-iodo-succinimide In acetonitrile at 20℃; for 24h; Inert atmosphere;	79%

: 64-18-6
formic acid

: 3218-36-8
4-Phenylbenzaldehyde

: 1591-31-7
4-iodo-biphenyl

Conditions

Conditions	Yield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 80℃; for 3h; Catalytic behavior; Schlenk technique; Green chemistry;	78%

: 624-38-4
para-diiodobenzene

: 98-80-6
phenylboronic acid

A: 92-94-4
[1,1';4',1'']terphenyl

B: 1591-31-7
4-iodo-biphenyl

Conditions

Conditions	Yield
With potassium carbonate; copper-palladium In N,N-dimethyl-formamide at 110℃; for 24h; Suzuki cross-coupling;	A 75% B 25%
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In 1,4-dioxane; methanol at 95℃; for 12h; Suzuki-Miyaura Coupling; Inert atmosphere;	A < 10 %Spectr. B 64%

...Expand

: [1,1'-biphenyl]-4-diazonium trifluoromethanesulfonate

: 1591-31-7
4-iodo-biphenyl

Conditions

Conditions	Yield
With potassium iodide In water at 20℃;	75%

: 624-38-4
para-diiodobenzene

: 71-43-2
benzene

A: 92-94-4
[1,1';4',1'']terphenyl

B: 1591-31-7
4-iodo-biphenyl

Conditions

Conditions	Yield
With potassium tert-butylate; N,N`-dimethylethylenediamine at 80℃; sealed tube; Inert atmosphere;	A 74% B 8%
With 1-(2-hydroxyethyl)piperazine; potassium tert-butylate at 100℃; for 24h; Sealed tube; Inert atmosphere;	A 69% B 7%
With potassium tert-butylate; vasicine at 20 - 110℃; for 48h; Schlenk technique; Inert atmosphere;	A 55% B 29%
With potassium tert-butylate for 6h; Inert atmosphere; Heating; High pressure;	A 21% B 30%

...Expand

: 91493-19-5
4-iodoxybiphenyl

: 1591-31-7
4-iodo-biphenyl

Conditions

Conditions	Yield
In nitrobenzene at 170℃; for 5h;	72%

: 1591-31-7
4-iodo-biphenyl

: 92-52-4
biphenyl

Conditions

Conditions	Yield
With LiCrH42LiCl2THF In tetrahydrofuran at 25℃; for 12h;	100%
With potassium tert-butylate; benzyl alcohol In N,N-dimethyl-formamide at 90℃; for 2h; Reagent/catalyst; Solvent; Schlenk technique; Inert atmosphere;	98%
With potassium tert-butylate; benzaldehyde In N,N-dimethyl-formamide at 90℃; for 2h; Schlenk technique; Inert atmosphere;	96%

: 1591-31-7
4-iodo-biphenyl

: C18H17CuF4N2O

: (2-tert-butoxy-1,1,2,2-tetrafluoroethyl)-4-phenylbenzene

Conditions

Conditions	Yield
In tetrahydrofuran at 60℃; for 24h; Inert atmosphere;	100%

: 1591-31-7
4-iodo-biphenyl

: 107-15-3
ethylenediamine

: N1-([1,1'-biphenyl]-4-yl)ethane-1,2-diamine

Conditions

Conditions	Yield
With copper(l) chloride; potassium hydroxide at 50℃; for 3h;	100%
With copper(l) chloride; potassium hydroxide at 50℃; for 3h; Ullmann Condensation; Inert atmosphere;	100%

: 64-17-5
ethanol

: 201230-82-2
carbon monoxide

: 1591-31-7
4-iodo-biphenyl

: 6301-56-0
ethyl 4-phenylbenzoate

Conditions

Conditions	Yield
With triethylamine; dichloro bis(acetonitrile) palladium(II) at 70℃; for 24h;	99%
With 1,8-diazabicyclo[5.4.0]undec-7-ene; [(Ph2CH=NOH)PdCl]2 In benzene at 120℃; for 3h;	90%

...Expand

: 1591-31-7
4-iodo-biphenyl

: 98-80-6
phenylboronic acid

: 92-94-4
[1,1';4',1'']terphenyl

Conditions

Conditions	Yield
With caesium carbonate In water; N,N-dimethyl-formamide at 20℃; for 50h; Suzuki Coupling; Inert atmosphere;	99%
With sodium acetate In water; N,N-dimethyl-formamide at 80℃; for 1h; Suzuki coupling;	90%
With C33H48Cl2N4O9Pd; oxygen; potassium carbonate In water at 80℃; Suzuki-Miyaura Coupling;	90%

: 1591-31-7
4-iodo-biphenyl

: 19813-90-2
4-biphenylthiol

Conditions

Conditions	Yield
With copper(ll) sulfate pentahydrate; ethane-1,2-dithiol; potassium hydroxide In water; dimethyl sulfoxide at 90℃; for 20h; Inert atmosphere;	99%
With sodiumsulfide nonahydrate; ethane-1,2-dithiol; copper(II) oxide In dimethyl sulfoxide at 120℃; for 20h; Inert atmosphere; Sealed tube;	97%
With sodiumsulfide nonahydrate; copper; ethane-1,2-dithiol In dimethyl sulfoxide at 100℃; for 20h; Inert atmosphere; Green chemistry;	97%
Stage #1: 4-iodo-biphenyl With copper(l) iodide; potassium carbonate; sulfur In N,N-dimethyl-formamide at 90℃; for 12h; Inert atmosphere; Stage #2: With sodium tetrahydroborate In N,N-dimethyl-formamide at 40℃; Inert atmosphere; Cooling with ice;	84%
With copper(l) iodide; thiourea; L-proline; sodium t-butanolate In dimethyl sulfoxide at 90℃; for 24h; Inert atmosphere;	83%

: 1591-31-7
4-iodo-biphenyl

: 92-69-3
4-Phenylphenol

Conditions

Conditions	Yield
With water; ethylene glycol; potassium hydroxide; copper dichloride In dimethyl sulfoxide at 120℃; for 24h; Reagent/catalyst; Temperature; Inert atmosphere;	99%
Stage #1: 4-iodo-biphenyl With copper(l) iodide; cesiumhydroxide monohydrate; 1,3-diphenylpropanedione In water; dimethyl sulfoxide at 130℃; for 24h; Inert atmosphere; Stage #2: With hydrogenchloride In dichloromethane; water; dimethyl sulfoxide at 20℃; Inert atmosphere; chemoselective reaction;	95%
Stage #1: 4-iodo-biphenyl With copper(l) iodide; 8-Hydroxyquinoline-N-oxide In dimethyl sulfoxide at 20℃; for 0.166667h; Inert atmosphere; Stage #2: With cesiumhydroxide monohydrate In water; dimethyl sulfoxide at 100℃; for 36h; Inert atmosphere;	93%

: 1591-31-7
4-iodo-biphenyl

: (1,10-phenanthroline)(perfluoropropyl)copper(l)

: 87415-24-5
4-(perfluoropropyl)-1,1′-biphenyl

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 50℃; for 18h; Product distribution / selectivity; Inert atmosphere;	99%

: 1591-31-7
4-iodo-biphenyl

: 75264-92-5
tetramethylammonium trifluoromethylselenate(0)

: 1447204-44-5
4-[(trifluoromethyl)selanyl]-1,1′-biphenyl

Conditions

Conditions	Yield
With [2,2]bipyridinyl; bis(1,5-cyclooctadiene)nickel (0) In tetrahydrofuran at 20℃; for 2h; Inert atmosphere;	99%
With C54H76I2N4Ni2 In benzene at 45℃; Inert atmosphere; Glovebox; chemoselective reaction;	99%
With palladium(l) tri-tert-butylphosphine iodide dimer In toluene at 40℃; for 24h; Glovebox; Inert atmosphere;	96%

: 74-85-1
ethene

: 1591-31-7
4-iodo-biphenyl

: 2350-89-2
p-vinylbiphenyl

Conditions

Conditions	Yield
With tri-tert-butylphosphonium tetrafluoroborate; N-Methyldicyclohexylamine; palladium diacetate In methanol; toluene at 120℃; under 11251.1 Torr; for 0.333333h; Wacker Oxidation; Flow reactor;	99%
With N-Methyldicyclohexylamine; palladium diacetate; tri tert-butylphosphoniumtetrafluoroborate In methanol; toluene at 120℃; under 11251.1 Torr; Flow reactor;	99%

: 1591-31-7
4-iodo-biphenyl

: 1-cyclopentyl-2,4,6-triphenylpyridin-1-ium tetrafluoroborate salt

: 4-cyclopentyl-1,1'-biphenyl

Conditions

Conditions	Yield
With [2,2]bipyridinyl; manganese; (1,2-dimethoxyethane)dichloronickel(II) In N,N-dimethyl acetamide at 20℃;	99%

: 1591-31-7
4-iodo-biphenyl

: trifluoromethyl-(3-chlorophenyl) bis(carbomethoxy)methylide

: 398-36-7
1-phenyl-4-(trifluoromethyl)benzene

Conditions

Conditions	Yield
With copper In N,N-dimethyl-formamide at 60℃; for 12h; Schlenk technique; Inert atmosphere; Sealed tube;	99%

: 636-98-6
p-nitrobenzene iodide

: 1591-31-7
4-iodo-biphenyl

: 4612-26-4
1,4-Phenyldiboronic acid

: 25627-14-9
4-nitro-1,1':4',1'':4'',1'''-quaterphenyl

Conditions

Conditions	Yield
Stage #1: p-nitrobenzene iodide; 1,4-Phenyldiboronic acid With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In methanol; water; toluene Suzuki cross-coupling; Stage #2: 4-iodo-biphenyl With tetrakis(triphenylphosphine) palladium(0) In methanol; water; toluene for 32h; Reflux;	98%

...Expand

: 1591-31-7
4-iodo-biphenyl

: 536-74-3
phenylacetylene

: 15784-39-1
4-(phenylethynyl)-1,1'-biphenyl

Conditions

Conditions	Yield
With copper(l) iodide; triethylamine; triphenylphosphine In water at 60℃; for 24h; Sonogashira Cross-Coupling; Schlenk technique; Inert atmosphere;	98%
With palladium diacetate; potassium carbonate In ethanol at 80℃; for 24h;	88%
With copper(l) iodide; tetrakis(triphenylphosphine)palladium dichloride; triethylamine In tetrahydrofuran at 80℃; for 12h; Inert atmosphere;	84%

: 1591-31-7
4-iodo-biphenyl

: 34880-70-1
[1-methoxyprop-1-enyloxy]trimethylsilane

: C16H16O2

Conditions

Conditions	Yield
With (R)-1-(bis(4-methoxy-3,5-dimethylphenyl)phosphano)-2-((S)-1-(dicyclohexylphosphano)ethyl)ferrocene; palladium diacetate; thallium(I) acetate In toluene at 70℃; for 6h; optical yield given as %ee; enantioselective reaction;	98%

: 1591-31-7
4-iodo-biphenyl

: 106-54-7
p-Chlorothiophenol

: 1361124-61-9
biphenyl-4-yl(4-chlorophenyl)sulfane

Conditions

Conditions	Yield
With tetra(n-butyl)ammonium hydroxide In water at 50℃; for 24h; Inert atmosphere; Sealed tube; chemoselective reaction;	98%

: 109-97-7
pyrrole

: 1591-31-7
4-iodo-biphenyl

: 1-([1,1'-biphenyl]-4-yl)-1H-pyrrole

Conditions

Conditions	Yield
With 4.5Cu(2+)4.5Ni(2+)9C16H12N26C2O4(2-)6H2O*P2W18O62(6-); sodium hydroxide In dimethyl sulfoxide at 120℃; for 12h;	98%
With MOF-199; sodium hydroxide In dimethyl sulfoxide at 120℃; for 12h; Sealed tube;	95%
With copper(ll) sulfate pentahydrate; sodium hydroxide In dimethyl sulfoxide at 110℃; for 12h; Sealed tube;	86%
With copper(II) acetate monohydrate; caesium carbonate In N,N-dimethyl-formamide at 20 - 110℃; for 24h; Inert atmosphere; Schlenk technique;	82%

: 119072-55-8, 7188-38-7
tert-butylisonitrile

: 1591-31-7
4-iodo-biphenyl

: 2920-38-9
4-cyano-1,1'-biphenyl

Conditions

Conditions	Yield
With copper (II) trifluoroacetate hydrate; palladium diacetate In dimethyl sulfoxide at 130℃; for 12h; Reagent/catalyst; Solvent; Sealed tube; Inert atmosphere;	98%

: 1591-31-7
4-iodo-biphenyl

(N-heterocyclic carbene)Ag(SCF2H): (N-heterocyclic carbene)Ag(SCF2H)

: [1,1'-biphenyl]-4-yl(difluoromethyl)thioether

Conditions

Conditions	Yield
With bis[2-(diphenylphosphino)phenyl] ether; bis(dibenzylideneacetone)-palladium(0) In toluene at 50℃; for 12h;	98%

: 1663-39-4
tert-Butyl acrylate

: 1591-31-7
4-iodo-biphenyl

: 910574-67-3
tert-butyl(E)-3-([1,1′-biphenyl]-4-yl)acrylate

Conditions

Conditions	Yield
With di-μ-iodobis(tri-t-butylphosphino)dipalladium(l); N-ethyl-N,N-diisopropylamine In toluene at 100℃; for 15h; Heck Reaction; Inert atmosphere; Sealed tube; Glovebox;	98%

: 401-55-8
ethyl bromofluoroacetate

: 1591-31-7
4-iodo-biphenyl

: 1234908-38-3
ethyl 2-(biphenyl-4-yl)-2-fluoroacetate

Conditions

Conditions	Yield
With bis[chloro(1,2,3-trihapto-allylbenzene)palladium(II)]; tetrabutylammomium bromide; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; zinc In tetrahydrofuran at 60℃; for 24h; Inert atmosphere;	98%

: 1591-31-7
4-iodo-biphenyl

: 1066-54-2
trimethylsilylacetylene

: 75867-42-4
([1,1'-biphenyl]-4-ylethynyl)trimethylsilane

Conditions

Conditions	Yield
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine at 20℃; for 1h;	97%
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide In triethylamine for 4h; Ambient temperature;	86%
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine In acetonitrile at 20℃; for 24h; Sonogashira Cross-Coupling; Schlenk technique; Inert atmosphere;	86%

: 1591-31-7
4-iodo-biphenyl

: tetramethylammonium trifluoromethanethiolate

: 177551-63-2
[1,1′-biphenyl]-4-yl(trifluoromethyl)sulfane

Conditions

Conditions	Yield
With palladium(l) tri-tert-butylphosphine iodide dimer In toluene at 80℃;	97%
With bis(1,5-cyclooctadiene)nickel(0); 4,4'-Dimethoxy-2,2'-bipyridin In tetrahydrofuran at 20℃; for 22h; Inert atmosphere;	92%

: 95-16-9
1,3-Benzothiazole

: 1591-31-7
4-iodo-biphenyl

: 403517-20-4
2-([1,1'-biphenyl]-4-ylthio)benzenamine

Conditions

Conditions	Yield
With tetra(n-butyl)ammonium hydroxide; water; copper(l) chloride at 50℃; for 12h; Inert atmosphere;	97%

4-Iodobiphenyl Chemical Properties

IUPAC Name:1-Iodo-4-phenylbenzene
Molecular Formula: C₁₂H₉I
Molecular Weight: 280.104330 g/mol
EINECS:216-469-1
Melting Point: 110-114 °C
Density: 1.584 g/cm³
Flash Point: 145.8 °C
Sensitive: Light
Boiling Point: 322.7 °C at 760 mmHg
Vapour Pressure: 0.000517 mmHg at 25 °C
Water Solubility: 0.9974 mg/L at 25 °C
Molecular Structure of 4-Iodobiphenyl (1591-31-7):

Categories of 4-Iodobiphenyl (1591-31-7): Biphenyl derivatives;pharmacetical;Halides;Phenyls & Phenyl-Het;Halogenated Hydrocarbons

4-Iodobiphenyl Uses

4-Iodobiphenyl (1591-31-7) is used as an intermediate of pharmaceutical and LCD.

4-Iodobiphenyl Safety Profile

Hazard Codes: Harmful Xn, Irritant Xi, Dangerous N
Risk Statements:22-41-50/53-36/37/38
22:Harmful if swallowed
41:Risk of serious damage to eyes
50/53:Very Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment
36/37/38:Irritating to eyes, respiratory system and skin
Safety Statements:26-39-60-61-37/39
26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
39:Wear eye/face protection
60:This material and/or its container must be disposed of as hazardous waste
61:Avoid release to the environment. Refer to special instructions safety data sheet
37/39:Wear suitable gloves and eye/face protection

4-Iodobiphenyl Specification

First Aid Measures of 4-Iodobiphenyl (1591-31-7):
Ingestion:If swallowed, wash out mouth with water provided person is conscious. Call a physician.
Inhalation:If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.
Skin:In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.
Eyes:In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Product Name

4-Iodobiphenyl

Synthetic route

4-Iodobiphenyl Chemical Properties

4-Iodobiphenyl Uses

4-Iodobiphenyl Safety Profile

4-Iodobiphenyl Specification

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