4-Nitrobenzyl alcohol supplier

Name
4-Nitrobenzyl alcohol
EINECS 210-611-6
CAS No. 619-73-8
Article Data479
CAS DataBase
Density 1.33 g/cm³
Solubility Soluble in water (2 mg/ml at 20°C).
Melting Point 92-94 °C(lit.)
Formula C₇H₇NO₃
Boiling Point 320.8 °C at 760 mmHg
Molecular Weight 153.137
Flash Point 148.1 °C
Transport Information
Appearance white to light yellow crystal powder
Safety 22-24/25-36/37/39-26-45-16
Risk Codes 36/37/38-34-11
Molecular Structure
Hazard Symbols Xi, C, F
Synonyms RARECHEM AL BD 0193;4-Nitrobenaylalcohol;4-NITROPHENYLCARBINOL;4-nitrobenzenemethanol;4-Nitrobenzyl alcoh;4-nitro-benzyl alcohol;p-nitro-benzylalcoho;4-Nitrobenzyl alcohol;p-nitrobenzyl-alcohol;Nitrobenzyl alcohol;
PSA 66.05000
LogP 1.61030

Synthetic route

: 555-16-8
4-nitrobenzaldehdye

: 619-73-8
4-nitrobenzyl chloride

Conditions

Conditions	Yield
With magnesium(II) perchlorate; 1-(phenyl-2-ethyl)-7-methyl-3,5-N,N-diethylaminocarbonyl-4,7-dihydropyrrolo<2,3-b>pyridine In acetonitrile at 60℃; for 1h; Product distribution; Rate constant; reduction of other benzaldehydes and ketones and carbon carbon double bonds;	100%
With magnesium(II) perchlorate; model of NADH grafted on silica matrix In acetonitrile at 65℃; for 120h; Product distribution; also with methyl benzoylformiate; varied lenght of chain, between reagent and surface of the support, reaction time, proportion of reagent/p-NBA;	100%
With magnesium(II) perchlorate; polymer-bound NADH (2a) In acetonitrile; benzene at 80℃; for 120h; Further byproducts given;	100%

: 122-04-3
4-nitro-benzoyl chloride

: 619-73-8
4-nitrobenzyl chloride

Conditions

Conditions	Yield
With Zn(BH4)2(Ph3P)2 In tetrahydrofuran at 20℃; Reduction;	100%
With N-methylpyrrolidine zinc borohydride In tetrahydrofuran at 20℃; for 0.583333h;	100%
With poly-η-(pyridine)zinc borohydride In diethyl ether for 6h; Ambient temperature;	98%

: 555-16-8
4-nitrobenzaldehdye

A: 619-73-8
4-nitrobenzyl chloride

B: C38H40N2OSi2

Conditions

Conditions	Yield
With 8-(N,N-dimethylaminomethyl)-1-naphthyl-(Ph)SiH2 at 25℃; for 12h;	A 100% B n/a

: C28H24BN4O12(1-)*Na(1+)

: 619-73-8
4-nitrobenzyl chloride

Conditions

Conditions	Yield
With water	100%

: 91-63-4
2-methylquinoline

: 555-16-8
4-nitrobenzaldehdye

A: 619-73-8
4-nitrobenzyl chloride

B: 1780-19-4
1,2,3,4-tetrahydro-2-methylquinoline

Conditions

Conditions	Yield
With (7,8-benzoquinolinato)hydrido(aqua)bis(triphenylphosphine)iridium(III) tetrakis[3,5-bis(trifluoromethyl)phenyl]borate; hydrogen In toluene at 80℃; for 18h;	A 100% B 78%

...Expand

: 619-90-9
4-nitrobenzyl acetate

: 619-73-8
4-nitrobenzyl chloride

Conditions

Conditions	Yield
With methanol; potassium permanganate; trimethylsulphonium iodide at 25℃; under 760.051 Torr; chemoselective reaction;	99%
With acetyl chloride In methanol at 20℃; for 21h;	96%
With methanol; oxo[hexa(trifluoroacetato)]tetrazinc for 6h; Reflux; Inert atmosphere;	95%

: 14856-73-6
4-nitrobenzyl trimethylsilyl ether

: 619-73-8
4-nitrobenzyl chloride

Conditions

Conditions	Yield
With bismuth(lll) trifluoromethanesulfonate In methanol at 20℃; for 0.0666667h;	99%
With methanol; 1,3-disulfonic acid imidazolium hydrogen sulfate at 20℃; for 0.116667h; Green chemistry;	99%
With Oxone In methanol for 0.25h; Heating;	97%

: 18483-99-3
2-(4-nitrobenzyloxy)tetrahydro-2H-pyran

: 619-73-8
4-nitrobenzyl chloride

Conditions

Conditions	Yield
With silica-supported NaHSO4 In methanol at 20℃; for 0.166667h;	99%
With bismuth(lll) trifluoromethanesulfonate In methanol for 0.0833333h; Heating;	96%
With silica triflate In methanol for 0.133333h; Heating;	95%

: 555-16-8
4-nitrobenzaldehdye

: 62-53-3
aniline

A: 619-73-8
4-nitrobenzyl chloride

B: 3460-11-5
4-nitrobenzanilide

Conditions

Conditions	Yield
Stage #1: aniline With n-butyllithium In tetrahydrofuran; hexane at -78 - 20℃; Inert atmosphere; Stage #2: 4-nitrobenzaldehdye With yttrium(III) chloride In toluene at 20℃; for 48h; Cannizzaro reaction; Inert atmosphere; Stage #3: With hydrogenchloride In water; toluene at 20℃; Inert atmosphere;	A n/a B 99%

...Expand

: 62-23-7
4-nitro-benzoic acid

: 619-73-8
4-nitrobenzyl chloride

Conditions

Conditions	Yield
With potassium borohydride; hafnium tetrachloride In tetrahydrofuran at 40℃; for 17.1h; Inert atmosphere; Cooling with ice;	98%
With zirconium(IV) borohydride In tetrahydrofuran at 25℃; for 1h; Reduction;	97%
With [Zn(BH4)2(py)] In tetrahydrofuran for 2.3h; Heating;	97%

: 100-44-7
benzyl chloride

: 619-73-8
4-nitrobenzyl chloride

Conditions

Conditions	Yield
With sulfur trioxide; water; nitric acid; sodium hydroxide In dichloromethane at 0 - 40℃; Large scale;	98%

: 99-99-0
1-methyl-4-nitrobenzene

: 619-73-8
4-nitrobenzyl chloride

Conditions

Conditions	Yield
Stage #1: 1-methyl-4-nitrobenzene With 2,2'-azobis(isobutyronitrile); chlorine at 120 - 130℃; Stage #2: With sodium acetate In toluene at 75 - 80℃; for 4h; Stage #3: With potassium hydroxide In methanol at 15 - 25℃; for 3h; Temperature; Reagent/catalyst;	97.2%
With sulfuric acid; fluorosulphonic acid; lead dioxide 1.) -20 deg C, 6 h, 2.) -50 deg C to -40 deg C;	30%
With sulfuric acid; water; acetic acid Electrolysis;
With sulfuric acid; lead dioxide
durch elektrolytische Oxydation;

: 100-39-0
benzyl bromide

: 619-73-8
4-nitrobenzyl chloride

Conditions

Conditions	Yield
With sulfur trioxide; water; nitric acid; sodium hydroxide In dichloromethane at 10 - 75℃; Large scale;	97.05%

: 99-77-4
ethyl 4-nitrobenzoate

: 619-73-8
4-nitrobenzyl chloride

Conditions

Conditions	Yield
Stage #1: ethyl 4-nitrobenzoate With diethylzinc; lithium chloride In tetrahydrofuran; hexane at 20℃; for 6h; Inert atmosphere; Stage #2: With sodium hydroxide In tetrahydrofuran; hexane; water at 20℃; for 8h; Inert atmosphere; chemoselective reaction;	97%
With potassium borohydride; hafnium tetrachloride In tetrahydrofuran at 40℃; for 13.1h; Inert atmosphere; Cooling with ice;	95%
With lithium borohydride In methanol; diethyl ether for 0.5h; Heating;	90%

: 139884-17-6
1-((methoxymethoxy)methyl)-4-nitrobenzene

: 619-73-8
4-nitrobenzyl chloride

Conditions

Conditions	Yield
phosphotungstic acid In ethanol for 1.5h; Heating;	97%
With carbon tetrabromide In isopropyl alcohol for 2.5h; Heating;	87%
With 1-methylimidazole hydrogen sulfate at 120℃; for 0.0916667h; Microwave irradiation; chemoselective reaction;	83%
With antibody 43D4-3D12; sodium acetate; sodium chloride In acetonitrile at 37℃; for 24h; enzyme kinetics;

: N,N-(Boc)2-4-nitrobenzamide

: 619-73-8
4-nitrobenzyl chloride

Conditions

Conditions	Yield
With sodium tetrahydroborate In ethanol at 20℃;	97%

: 2733-41-7
4-nitrobenzoyl azide

: 619-73-8
4-nitrobenzyl chloride

Conditions

Conditions	Yield
With zinc(II) tetrahydroborate In 1,2-dimethoxyethane for 4h; Ambient temperature;	96%

: 100-11-8
1-bromomethyl-4-nitro-benzene

: 619-73-8
4-nitrobenzyl chloride

Conditions

Conditions	Yield
With 1-dodecyl-3-methylimidazol-1-ium bromide; water; zinc dibromide at 90℃; for 3h; Reagent/catalyst;	96%
With water; sodium formate; sodium carbonate at 100 - 105℃; for 1h; pH=7 - 7.5; Reagent/catalyst;	94.7%
With oxygen; eosin y In dimethyl sulfoxide at 25℃; for 12h; Irradiation;	91%

: C15H22BNO3

: 619-73-8
4-nitrobenzyl chloride

Conditions

Conditions	Yield
With sodium hydroxide In water Inert atmosphere;	96%

: 100-14-1
4-nitrobenzyl chloride

: 619-73-8
4-nitrobenzyl chloride

Conditions

Conditions	Yield
With water; 1-butyl-3-methylimidazolium chloride; zinc(II) chloride at 100℃; for 7h; Reagent/catalyst;	95%
With water; sodium formate; potassium carbonate at 100 - 105℃; for 1h; pH=7 - 7.5; Reagent/catalyst;	93.6%
With iron(III) sulfate; water In toluene at 110℃; for 3h; Ionic liquid;	92%

: 619-50-1
4-nitrobenzoic acid methyl ester

: 619-73-8
4-nitrobenzyl chloride

Conditions

Conditions	Yield
With zirconium(IV) borohydride In tetrahydrofuran at 25℃; for 2h; Reduction;	95%
With sodium tetrahydroborate; sodium methylate In methanol at 25℃; for 3h; Inert atmosphere;	95%
With methanol; sodium tetrahydroborate; sodium methylate at 60℃; for 0.333333h; Reagent/catalyst; Temperature;	95%

: 135605-97-9
tert-butyldimethyl-4-nitrobenzyloxysilane

: 619-73-8
4-nitrobenzyl chloride

Conditions

Conditions	Yield
With hafnium tetrakis(trifluoromethanesulfonate) In methanol at 20℃; for 12h;	95%
With hafnium tetrakis(trifluoromethanesulfonate) In methanol at 20℃; for 12h;	95%
With sodium periodate In ethanol at 20℃; for 2h; Product distribution; Further Variations:; Solvents;	94%

: 4457-41-4
4-nitrobenzyl benzoate

: 619-73-8
4-nitrobenzyl chloride

Conditions

Conditions	Yield
With sodium methylate In methanol at 20℃; for 12h;	95%
With methanol; oxo[hexa(trifluoroacetato)]tetrazinc for 18h; Reflux; Inert atmosphere;	> 99 %Chromat.
With water; potassium carbonate In methanol Reagent/catalyst; chemoselective reaction;

: potassium (acetoxymethyl)trifluoroborate

: 100-00-5
4-chlorobenzonitrile

: 619-73-8
4-nitrobenzyl chloride

Conditions

Conditions	Yield
With sodium carbonate; bis(dibenzylideneacetone)-palladium(0); ruphos In 1,4-dioxane; water for 24h; Suzuki-Miyaura cross-coupling; Inert atmosphere; Reflux;	94.4%

: 555-16-8
4-nitrobenzaldehdye

A: 619-73-8
4-nitrobenzyl chloride

B: 62-23-7
4-nitro-benzoic acid

Conditions

Conditions	Yield
Stage #1: 4-nitrobenzaldehdye With potassium hydroxide In water at 20℃; Cannizzaro reaction; Stage #2: With hydrogenchloride In water	A 91% B 93%
With sodium hydroxide In water at 30℃; for 5h; Cannizzaro Reaction;	A n/a B 90%
With TEA; magnesium bromide In dichloromethane at 20℃; for 24h; Cannizzaro reaction;	A 85% B n/a

: 555-16-8
4-nitrobenzaldehdye

A: 619-73-8
4-nitrobenzyl chloride

B: 619-80-7
4-nitrobenzamide

Conditions

Conditions	Yield
Stage #1: 4-nitrobenzaldehdye With μ-Cl In dichloromethane at 20℃; for 48h; Stage #2: With hydrogenchloride	A 88% B 93%

: 1058649-42-5
4-nitro-1-[(ethoxymethoxy)methyl]benzene

: 619-73-8
4-nitrobenzyl chloride

Conditions

Conditions	Yield
phosphotungstic acid In ethanol for 2h; Heating;	93%
With 1-methylimidazole hydrogen sulfate at 120℃; for 0.0833333h; Microwave irradiation; chemoselective reaction;	89%

: 1143018-83-0
2-((4-nitrobenzyl)oxy)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 619-73-8
4-nitrobenzyl chloride

Conditions

Conditions	Yield
With silica gel In methanol at 60℃; for 3h; Inert atmosphere;	93%
With silica gel at 25℃; Inert atmosphere; Glovebox;	92%
With silica gel In hexane; ethyl acetate	90%

Wang resin-(CH2)-bound p-nitrobenzyl carbonate: Wang resin-(CH2)-bound p-nitrobenzyl carbonate

: 619-73-8
4-nitrobenzyl chloride

Conditions

Conditions	Yield
With triethylamine In methanol Heating;	92%

: 619-73-8
4-nitrobenzyl chloride

: 623-04-1
4-aminobenzenemethanol

Conditions

Conditions	Yield
With copper(I) chloride; potassium borohydride In methanol for 0.416667h; Ambient temperature;	100%
With hydrazine hydrate In ethanol at 78℃; for 24h;	100%
With hydrogen In methanol at 20℃; under 760.051 Torr; for 5h;	100%

: 619-73-8
4-nitrobenzyl chloride

: 555-16-8
4-nitrobenzaldehdye

Conditions

Conditions	Yield
With bis(2,2'-bipyridyl) copper(II) permanganate In dichloromethane for 1.5h; Ambient temperature;	100%
With pyridine chromium peroxide In benzene for 0.2h; Heating;	100%
With tert.-butylhydroperoxide; polystyrene-bound phenylselenic acid In tetrachloromethane for 5h; Heating;	100%

: 619-73-8
4-nitrobenzyl chloride

: 100-11-8
1-bromomethyl-4-nitro-benzene

Conditions

Conditions	Yield
Stage #1: 4-nitrobenzyl chloride With 1,2-Diiodoethane; N,N-dimethyl-formamide; triphenylphosphine at 20℃; for 0.0166667h; Sealed tube; Inert atmosphere; Stage #2: With tetrabutylammomium bromide at 20℃; Sealed tube; Inert atmosphere;	100%
With N-Bromosuccinimide; triphenylphosphine for 0.00555556h; microwave irradiation;	98%
Stage #1: 4-nitrobenzyl chloride With diisopropyl-carbodiimide; copper(II) bis(trifluoromethanesulfonate) In tetrahydrofuran at 100℃; for 0.0833333h; microwave irradiation; Stage #2: With Acetyl bromide In tetrahydrofuran at 150℃; for 0.0833333h; microwave irradiation; Further stages.;	98%

: 619-73-8
4-nitrobenzyl chloride

: 62-23-7
4-nitro-benzoic acid

Conditions

Conditions	Yield
With 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; sodium chlorite In acetonitrile at 35℃; pH 6.7;	100%
With sodium hypochlorite; sodium chlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical In aq. phosphate buffer; water; acetonitrile at 35℃; pH=6.7; Green chemistry;	100%
With gold oxide; oxygen; copper(II) oxide; sodium hydroxide; silver(l) oxide In water at 40℃; under 750.075 Torr; for 16h;	100%

: 619-73-8
4-nitrobenzyl chloride

: 185749-52-4
(4-Nitro-phenyl)-methanol anion

Conditions

Conditions	Yield
With potassium hydride; cryptand 222B In tetrahydrofuran for 0.0166667h; other reagents, other times, other solvent, other yields;	100%
With potassium hydride; cryptand 222B In tetrahydrofuran for 0.0166667h;	100%

: 619-73-8
4-nitrobenzyl chloride

: 86963-19-1
tri(p-nitrobenzyl)phosphite

Conditions

Conditions	Yield
With Hexamethylphosphorous triamide at 100℃; for 2h;	100%
With Hexamethylphosphorous triamide at 100℃;

: 110-87-2
3,4-dihydro-2H-pyran

: 619-73-8
4-nitrobenzyl chloride

: 18483-99-3
2-(4-nitrobenzyloxy)tetrahydro-2H-pyran

Conditions

Conditions	Yield
With titanium(IV) salophen trifluoromethanesulfonate In dichloromethane at 20℃; for 0.0333333h; chemoselective reaction;	100%
With pyridinium p-toluenesulfonate In dichloromethane for 1.5h;	99%
With P-benzyltriphenylphosphonium tribromide In dichloromethane at 20℃; for 0.0833333h;	97%

: 619-73-8
4-nitrobenzyl chloride

: 187269-63-2
2,3,4,6-tetra-O-pivaloyl-α-D-mannopyranosyl fluoride

: 243120-94-7
4-nitrobenzyl tetra-O-pivaloyl-α-D-mannopyranoside

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate In dichloromethane at 4℃; Substitution;	100%

: 619-73-8
4-nitrobenzyl chloride

: 18162-48-6
tert-butyldimethylsilyl chloride

: 135605-97-9
tert-butyldimethyl-4-nitrobenzyloxysilane

Conditions

Conditions	Yield
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 2.5h; silylation;	100%
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 1.5h; silylation;	100%
With triethylamine In tetrahydrofuran at 20℃; for 95h; Time;	99%

: 619-73-8
4-nitrobenzyl chloride

: 4132-86-9, 26607-51-2, 1142-20-7
N-benzyloxycarbonylalanine

: 247089-50-5
N-Benzyloxycarbonyl-D,L-alanine 4-nitrobenzyl ester

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 20h;	100%

: 619-73-8
4-nitrobenzyl chloride

: 106-49-0
p-toluidine

Conditions

Conditions	Yield
With triethylsilane; palladium dichloride In ethanol at 20℃; for 0.5h; Inert atmosphere;	100%
With hydrogen In ethanol at 80℃; under 2250.23 Torr; for 5h; Catalytic behavior; Inert atmosphere;	95%
With [IrCl(CO)(PPh3)2]; hydrazine hydrate; potassium hydroxide In methanol at 160℃; for 3h; Wolff-Kishner Reduction; Sealed tube;	51%

: 619-73-8
4-nitrobenzyl chloride

: 75-36-5
acetyl chloride

: 619-90-9
4-nitrobenzyl acetate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 3h;	100%
With hydroxyapatite supported copper(I) oxide In acetonitrile at 50℃; for 0.0833333h; Reagent/catalyst;	93%

: 619-73-8
4-nitrobenzyl chloride

polymer, ring-opening metathesis polymerization, degree of polymerization 60; monomer(s): 2-chlorosulfonyl-5-norbornene; ethyl vinyl ether: polymer, ring-opening metathesis polymerization, degree of polymerization 60; monomer(s): 2-chlorosulfonyl-5-norbornene; ethyl vinyl ether

polymer, degree of polymerization 60; monomer(s): 2-chlorosulfonyl-5-norbornene; ethyl vinyl ether; 4-nitrobenzyl alcohol: polymer, degree of polymerization 60; monomer(s): 2-chlorosulfonyl-5-norbornene; ethyl vinyl ether; 4-nitrobenzyl alcohol

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃;	100%

: 619-73-8
4-nitrobenzyl chloride

: 1944-96-3
O-(p-nitrobenzyl)hydroxylamine

Conditions

Conditions	Yield
Stage #1: 4-nitrobenzyl chloride With di-isopropyl azodicarboxylate; N-hydroxyphthalimide resin; triphenylphosphine; 1H-imidazole In dichloromethane at 20℃; for 24h; Mitsunobu reaction; Stage #2: With methylamine In methanol; chloroform at 20℃; for 2h;	100%
Multi-step reaction with 2 steps 1: PPh3; DEAD / tetrahydrofuran / 0 - 50 °C 2: 80 percent / N2H4*H2O / ethanol / 78 °C View Scheme
Multi-step reaction with 2 steps 1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere 2: hydrazine hydrate / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere View Scheme

: ammonium thiocyanate

: 619-73-8
4-nitrobenzyl chloride

: 13287-49-5
4-Nitro-benzylthiocyanat

Conditions

Conditions	Yield
Stage #1: ammonium thiocyanate With 1-chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octanebis(tetrafluoroborate) In acetonitrile at 20℃; for 0.333333h; Stage #2: 4-nitrobenzyl chloride In acetonitrile for 1h;	100%

: 619-73-8
4-nitrobenzyl chloride

: 1-bromo-4-methoxy-9,10,11,12-tetrahydro-6H-naphtho[2,1-c]chromen-6-one

: 4-nitrobenzyl (R)-1-(6-bromo-2-hydroxy-3-methoxyphenyl)-5,6,7,8-tetrahydronaphthalene-2-carboxylate

Conditions

Conditions	Yield
With C29H28F6N4OS at 20℃; for 1.5h; enantioselective reaction;	100%

: 619-73-8
4-nitrobenzyl chloride

: tert-butyl 2-benzamidonicotinate

: 4457-41-4
4-nitrobenzyl benzoate

Conditions

Conditions	Yield
With t-butyl nicotinate; zinc diacetate at 40℃; for 24h; chemoselective reaction;	100%

: 619-73-8
4-nitrobenzyl chloride

: C24H20P(1+)*C28H32AlN4(1-)

: C24H20P(1+)*C35H39AlN5O3(1-)

Conditions

Conditions	Yield
In dichloromethane-d2 at 20℃;	100%

: 64-18-6
formic acid

: 619-73-8
4-nitrobenzyl chloride

: 30039-42-0
4-nitrobenzyl formate

Conditions

Conditions	Yield
Stage #1: formic acid With dicyclohexyl-carbodiimide In dichloromethane at 0℃; Inert atmosphere; Stage #2: 4-nitrobenzyl chloride With dmap In dichloromethane for 0.5h;	99.4%
Stage #1: formic acid With silica gel at 20℃; for 0.0166667h; Stage #2: 4-nitrobenzyl chloride With silica gel at 110℃; for 0.05h;	95%
With iodine at 20℃; for 1h; neat (no solvent);	88%

: 619-73-8
4-nitrobenzyl chloride

: 108-24-7
acetic anhydride

: 619-90-9
4-nitrobenzyl acetate

Conditions

Conditions	Yield
K5 In acetonitrile at 20℃; for 0.25h;	99%
With thalium(III) chloride tetrahydrate at 20℃; for 0.116667h;	99%
With polyvinylpolypyrrolidone-bound boron trifluoride In acetonitrile at 20℃; for 2h;	99%

: 619-73-8
4-nitrobenzyl chloride

: 64-19-7
acetic acid

: 619-90-9
4-nitrobenzyl acetate

Conditions

Conditions	Yield
With bismuth(III) chloride for 1.25h; Heating;	99%
With K5 for 0.75h; Heating;	98%
With potassium fluoride at 80℃; for 3h;	97%

: 619-73-8
4-nitrobenzyl chloride

: 545-06-2
trichloroacetonitrile

: 163193-79-1
4-nitrobenzyl 2,2,2-trichloroethanimidoate

Conditions

Conditions	Yield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane at 20℃; for 7h; Inert atmosphere;	99%
With 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane at 0℃; Inert atmosphere;	97%
Stage #1: 4-nitrobenzyl chloride With 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane at 20℃; for 0.25h; Inert atmosphere; Stage #2: trichloroacetonitrile In dichloromethane at 0 - 20℃; for 18h; Inert atmosphere;	96%
With sodium hydride In tetrahydrofuran	95%
With 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane at 20℃; for 3.5h;	92%

4-Nitrobenzyl alcohol Specification

4-Nitrobenzyl alcohol, with CAS number of 619-73-8, can be called (4-Nitrophenyl)methanol; 4-Nitrobenzenemethanol; 4-Nitrobenzyl alcohol; p-(Hydroxymethyl)nitrobenzene; p-Nitrobenzyl alcohol. It belongs to the Product Categories of Fine chemical & intermediates; Benzhydrols, Benzyl & Special Alcohols; Alcohols; C7 to C8; Oxygen Compounds.The Molecular Formula of it is C₇H₇NO₃ and the Molecular Weight is 153.13538.

Physical properties about 4-Nitrobenzyl alcohol are: (1)ACD/LogP: 0.831; (2)ACD/LogD (pH 5.5): 0.83; (3)ACD/LogD (pH 7.4): 0.83; (4)ACD/BCF (pH 5.5): 2.52; (5)ACD/BCF (pH 7.4): 2.52; (6)ACD/KOC (pH 5.5): 67.49; (7)ACD/KOC (pH 7.4): 67.49; (8)#H bond acceptors: 4; (9)#H bond donors: 1; (10)#Freely Rotating Bonds: 3; (11)Index of Refraction: 1.598; (12)Molar Refractivity: 39.25 cm³; (13)Molar Volume: 115.092 cm³; (14)Polarizability: 15.56 10-24cm³; (15)Surface Tension: 57.0449981689453 dyne/cm; (16)Density: 1.331 g/cm³; (17)Flash Point: 148.078 °C; (18)Enthalpy of Vaporization: 59.389 kJ/mol; (19)Boiling Point: 320.847 °C at 760 mmHg; (20)

When you are using this chemical, please be cautious about it as the following:
1. Do not breathe dust;
2. Avoid contact with skin and eyes;
3. Wear suitable protective clothing, gloves and eye/face protection;
4. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice;
5. In case of accident or if you feel unwell, seek medical advice immediately (show label where possible);
6. Keep away from sources of ignition - No smoking;

You can still convert the following datas into molecular structure:
(1)InChI=1S/C7H7NO3/c9-5-6-1-3-7(4-2-6)8(10)11/h1-4,9H,5H2;
(2)InChIKey=JKTYGPATCNUWKN-UHFFFAOYSA-N;
(3)Smiles[O-][N+](=O)c1ccc(cc1)CO;

Product Name

4-Nitrobenzyl alcohol

Synthetic route

4-Nitrobenzyl alcohol Specification

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