Anisic acid supplier | CasNO.100-09-4

Name
Anisic acid
EINECS 202-818-5
CAS No. 100-09-4
Article Data1469
CAS DataBase
Density 1.208 g/cm³
Solubility Soluble in alcohol, ether, chloroform, slightly soluble in water, insoluble in cold water
Melting Point 181-186 °C
Formula C₈H₈O₃
Boiling Point 278.305 °C at 760 mmHg
Molecular Weight 152.15
Flash Point 115.46 °C
Transport Information 25kgs
Appearance White powder
Safety 24/25
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms p-Anisicacid (6CI,7CI,8CI);4-Anisic acid;4-Methoxybenzoic acid;Draconicacid;NSC 32742;NSC 7926;p-Methoxybenzoic acid;
PSA 46.53000
LogP 1.39340

Synthetic route

: 104-93-8
4-Methylanisole

: 100-09-4
4-methoxybenzoic acid

Conditions

Conditions	Yield
With carbon tetrabromide; oxygen; triphenylphosphine In ethyl acetate for 10h; fluorescent irradiation;	100%
With oxygen; cobalt(II) acetate; manganese(II) acetate; 1N,3N,5N-trihydroxy-1,3,5-triazin-2,4,6[1H,3H,5H]-trione In acetic acid at 80℃; for 6h;	99%
With Iron(III) nitrate nonahydrate; dihydrogen peroxide; oxygen; manganese(II) acetate; acetic acid at 25℃; under 30003 Torr; for 0.0266111h;	95%

: 123-11-5
4-methoxy-benzaldehyde

: 100-09-4
4-methoxybenzoic acid

Conditions

Conditions	Yield
With hydrogen bromide; oxygen In acetonitrile at 20℃; for 5h; UV-irradiation;	100%
With [Cu2C6H4(CHNCH2CH2N(CH2C5H4N)2)2](2+)*2ClO4(1-)=C36H38Cu2N8(ClO4)2; oxygen In acetone at -90.16℃;	100%
With cobalt(II) 2,9,16,23-phthalocyanine tetrasulfonic acid In water; acetonitrile at 20℃; under 760.051 Torr; for 150h; Reagent/catalyst; Solvent; UV-irradiation;	100%

: 105-13-5
4-Methoxybenzyl alcohol

: 100-09-4
4-methoxybenzoic acid

Conditions

Conditions	Yield
With Au NCs/TiO2; oxygen; sodium hydroxide In water at 80℃; under 7500.75 Torr; for 6h; Autoclave; Green chemistry;	100%
With palladium 10% on activated carbon; water; sodium hydroxide at 80℃; under 600.06 Torr; for 6h;	100%
With gold oxide; oxygen; copper(II) oxide; sodium hydroxide; silver(l) oxide In water at 40℃; under 750.075 Torr; for 16h;	100%

: 67-56-1
methanol

: 145224-20-0
4-Methoxy-benzoic acid 4-cyano-naphthalen-1-ylmethyl ester

A: 36062-93-8
1-cyano-4-methylnaphthalene

B: 112929-94-9
1-cyano-4-(methoxymethyl)naphthalene

C: 100-09-4
4-methoxybenzoic acid

D: C24H16N2

Conditions

Conditions	Yield
Irradiation;	A 5 % Chromat. B 66 % Chromat. C 100% D 22 % Chromat.

...Expand

: 6941-68-0
allyl 4-methoxybenzoate

: 100-09-4
4-methoxybenzoic acid

Conditions

Conditions	Yield
With formic acid; triethylamine In acetonitrile at 80℃; for 1h; Inert atmosphere;	100%
With sodium hydrogen telluride; acetic acid In ethanol for 2h; Heating;	95%
With toluene-4-sulfonic acid for 0.0666667h; microwave irradiation;	82%
With iodine; dimethyl sulfoxide for 0.5h; Heating;	75%

: 145224-20-0
4-Methoxy-benzoic acid 4-cyano-naphthalen-1-ylmethyl ester

A: 36062-93-8
1-cyano-4-methylnaphthalene

B: 112929-94-9
1-cyano-4-(methoxymethyl)naphthalene

C: 100-09-4
4-methoxybenzoic acid

D: C24H16N2

Conditions

Conditions	Yield
In methanol Irradiation;	A 5 % Chromat. B 66 % Chromat. C 100% D 22 % Chromat.
In methanol Irradiation;	A 39 % Chromat. B 60 % Chromat. C 61% D 2 % Chromat.

...Expand

: 52509-81-6
potassium 4-methoxybenzoate

: 100-09-4
4-methoxybenzoic acid

Conditions

Conditions	Yield
Hydrolysis;	100%

: 121-98-2
methyl 4-methoxybenzoate

: 100-09-4
4-methoxybenzoic acid

Conditions

Conditions	Yield
With lithium chloride In N,N-dimethyl-formamide for 0.166667h; Microwave irradiation; chemoselective reaction;	99%
Stage #1: methyl 4-methoxybenzoate With sodium hydroxide In methanol at 60 - 65℃; for 3h; Stage #2: With hydrogenchloride In methanol; water	99.67%
With pyridine; iodine; aluminium In acetonitrile at 80℃; for 18h; Solvent; Reagent/catalyst; Temperature;	98%

: 100-06-1
1-(4-methoxyphenyl)ethanone

: 100-09-4
4-methoxybenzoic acid

Conditions

Conditions	Yield
With copper(II) nitrate trihydrate; oxygen In acetonitrile at 120℃; under 4500.45 Torr; for 10h; Autoclave;	99%
With oxygen; copper(II) nitrate In acetonitrile at 120℃; under 4500.45 Torr; for 10h;	99%
With copper(l) iodide; hydroxylamine hydrochloride; oxygen In dimethyl sulfoxide at 100℃; for 8h; Solvent; Reagent/catalyst; Temperature;	95%

: 124-38-9
carbon dioxide

: 696-62-8
para-iodoanisole

: 100-09-4
4-methoxybenzoic acid

Conditions

Conditions	Yield
With 3,4-benzo-1,1,2,2-tetraethyl-1,2-disilacyclobut-3-ene; cesium fluoride In N,N-dimethyl-formamide at 0 - 20℃; under 760.051 Torr; for 2h; Reagent/catalyst;	99%
With tetraethylammonium tosylate; triphenylphosphine; tetrakis(triphenylphosphine) palladium(0) In N,N-dimethyl-formamide Pt anode/Pt cathode; electrolysis with 2.5 mA/cm2;	82%
With copper(l) iodide; N,N,N,N,-tetramethylethylenediamine; diethylzinc In dimethyl sulfoxide at 70℃; under 760.051 Torr;	60%

: 201230-82-2
carbon monoxide

: 696-62-8
para-iodoanisole

: 100-09-4
4-methoxybenzoic acid

Conditions

Conditions	Yield
With water; potassium carbonate In acetonitrile at 100℃; under 3750.38 Torr; for 0.0161111h;	99%
With dichloro bis(acetonitrile) palladium(II); potassium hydroxide; sodium dodecyl-sulfate In water; toluene; butan-1-ol at 50℃; under 760 Torr; for 4h;	96%
With potassium hydroxide; amphiphilic resin-supported phosphine-palladium; water at 25℃; under 760 Torr; for 12h; Product distribution; Further Variations:; Reagents; hydroxycarbonylation;	96%

: 24318-43-2
4-methoxybenzyl 4-methoxybenzoate

: 100-09-4
4-methoxybenzoic acid

Conditions

Conditions	Yield
With proton-exchanged montmorillonite In dichloromethane at 20℃;	99%
With trichlorophosphate In 1,2-dichloro-ethane at 20℃; for 1h;	88%
With oxalyl dichloride In 1,2-dichloro-ethane at 20℃; for 2.66667h;	75%

: 19513-80-5
2-(2-methoxyphenoxy)-1-(4-methoxyphenyl)ethan-1-one

A: 90-05-1
2-methoxy-phenol

B: 100-09-4
4-methoxybenzoic acid

Conditions

Conditions	Yield
With oxygen; copper(II) nitrate In acetonitrile at 120℃; under 4500.45 Torr; for 10h;	A n/a B 99%
With oxygen; copper diacetate; triethylamine In dimethyl sulfoxide at 20℃; for 12h; Sealed tube;	A 93% B 83%
With water; oxalic acid at 100℃; for 24h; Reagent/catalyst;	A 21 mg B 73%

: 140455-39-6
2-(2,6-dimethoxyphenoxy)-1-(4-methoxyphenyl)ethan-1-one

A: 91-10-1
1,3-dimethoxy-2-hydroxy-benzene

B: 100-09-4
4-methoxybenzoic acid

Conditions

Conditions	Yield
With oxygen; copper(II) nitrate In acetonitrile at 120℃; under 4500.45 Torr; for 10h;	A n/a B 99%

: 123-11-5
4-methoxy-benzaldehyde

A: 100-09-4
4-methoxybenzoic acid

B: 105-13-5
4-Methoxybenzyl alcohol

Conditions

Conditions	Yield
With Ximenia american In aq. phosphate buffer; water at 30℃; for 72h; pH=7; Enzymatic reaction;	A n/a B 98%
Stage #1: 4-methoxy-benzaldehyde With potassium hydroxide for 0.0833333h; Cannizzaro Reaction; Milling; Inert atmosphere; Sealed tube; Green chemistry; Stage #2: With hydrogenchloride In water Green chemistry;	A 95% B 94%
With sodium hydroxide In water at 15℃; for 2h; Cannizzaro Reaction;	A 91% B n/a

: 104-92-7
1-bromo-4-methoxy-benzene

: 201230-82-2
carbon monoxide

: 100-09-4
4-methoxybenzoic acid

Conditions

Conditions	Yield
With tetrabutylammomium bromide; dicobalt octacarbonyl In sodium hydroxide; benzene at 65℃; for 2h; Irradiation; variation of reaction medium;	98%
With tetrabutylammomium bromide; dicobalt octacarbonyl In sodium hydroxide; benzene at 65℃; for 2h; Irradiation; variation of reaction medium;	98%
With sodium hydroxide; tetrabutylammomium bromide; dicobalt octacarbonyl In water; benzene at 65℃; under 760 Torr; for 2h; Irradiation;	94%

: 114050-46-3
N-(4-methoxybenzoyloxy)-pyridine-2(1H)-thione

: 75-66-1
2-methylpropan-2-thiol

A: 24367-44-0
2-(2-tert-butyldisulfanyl)pyridine

B: 100-09-4
4-methoxybenzoic acid

Conditions

Conditions	Yield
In dichloromethane Irradiation;	A 86% B 98%

...Expand

: 7465-88-5
4-methoxy-N-phenylbenzamide

A: 100-09-4
4-methoxybenzoic acid

B: 62-53-3
aniline

Conditions

Conditions	Yield
With 40% potassium fluoride/alumina for 0.0666667h; Microwave irradiation; Neat (no solvent);	A 98% B 92%

: 213468-59-8
S-methyl 3-oxo-3-(4-methoxylphenyl)propanedithioate

: 100-09-4
4-methoxybenzoic acid

Conditions

Conditions	Yield
With sodium hydroxide In water at 100℃; for 10h; Reagent/catalyst; Reflux; chemoselective reaction;	98%

: 4-((tert-butyldimethylsilyl)oxy)benzyl 4-methoxybenzoate

: 100-09-4
4-methoxybenzoic acid

Conditions

Conditions	Yield
With tetrabutyl ammonium fluoride In tetrahydrofuran at 20℃; for 0.5h;	98%

: 833-79-4
t-butyl 4-methoxybenzoate

: 100-09-4
4-methoxybenzoic acid

Conditions

Conditions	Yield
With ytterbium(III) triflate In nitromethane at 45 - 50℃; for 18h;	97%
With zinc dibromide In dichloromethane for 6h; dealkylation;	93%
With toluene-4-sulfonic acid for 0.0666667h; microwave irradiation;	92%
With silica gel In toluene for 7h; Heating;	68%

: 119-52-8
4,4'-dimethoxybenzoin

: 100-09-4
4-methoxybenzoic acid

Conditions

Conditions	Yield
With dihydrogen peroxide; methyltrioxorhenium(VII); magnesium sulfate In acetonitrile for 3.5h; Heating;	97%
With diphenyl diselenide; dihydrogen peroxide In water; acetonitrile at 20℃; for 24h;	88%
With oxygen; potassium hydroxide at 20℃; Schlenk technique; chemoselective reaction;	87%

: 124-38-9
carbon dioxide

: 213596-33-9
2-(4-methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborolane

: 100-09-4
4-methoxybenzoic acid

Conditions

Conditions	Yield
With potassium tert-butylate; copper(l) chloride; 1,3-bis[2,6-diisopropylphenyl]imidazolium chloride In tetrahydrofuran at 70℃; under 760.051 Torr; for 24h;	97%
Stage #1: carbon dioxide; 2-(4-methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborolane With [Ni(N,N'-bis[2,6-bis(diphenylmethyl)-4-methylphenyl]imidazole-2-ylidene)(allyl)Cl]; potassium tert-butylate In toluene at 100℃; under 760.051 Torr; for 15h; Schlenk technique; Inert atmosphere; Stage #2: With hydrogenchloride In water; ethyl acetate; toluene at 20℃; Solvent; Temperature; Reagent/catalyst;	96%
With 1,3-bis-(diphenylphosphino)propane; cesium fluoride; [Rh(OH)(cod)]2 In 1,4-dioxane at 60℃;	95%

: 57297-25-3
1-(4-methoxyphenyl)-2-(4-methylphenyl)ethanone

A: 99-94-5
p-Toluic acid

B: 100-09-4
4-methoxybenzoic acid

Conditions

Conditions	Yield
With oxygen; potassium hydroxide at 20℃; Schlenk technique; chemoselective reaction;	A 93% B 97%

: 6316-54-7
4-methoxy-benzoic acid benzyl ester

: 100-09-4
4-methoxybenzoic acid

Conditions

Conditions	Yield
With palladium diacetate; sodium hydride In N,N-dimethyl acetamide at 60℃; for 2h; Inert atmosphere;	96%
With palladium diacetate; sodium hydride In N,N-dimethyl acetamide at 50℃; for 5h; Inert atmosphere;	96%
With aluminum oxide for 0.333333h; microwave irradiation;	89%
With methanol; sodium tetrahydroborate; nickel(II) chloride hexahydrate at 20℃; for 0.333333h; chemoselective reaction;	88%

: 696-62-8
para-iodoanisole

: 18414-58-9
diphenylmethylsilanecarboxylic acid

: 100-09-4
4-methoxybenzoic acid

Conditions

Conditions	Yield
With potassium trimethylsilonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; bis(dibenzylideneacetone)-palladium(0) In toluene at 40℃; for 0.333333h; Reagent/catalyst; Solvent; Time; Temperature;	96%

: 14660-45-8
potassium monomethylcarbonate

: 213596-33-9
2-(4-methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborolane

: 100-09-4
4-methoxybenzoic acid

Conditions

Conditions	Yield
With chloro[1,3-bis(2,6-di-i-propylphenyl)imidazol-2-ylidene]copper(I) In tetrahydrofuran at 70℃; for 16h; Inert atmosphere; Sealed tube;	96%

: 2729-19-3
2-(4-Fluorophenyl)-1-(4-methoxyphenyl)ethan-1-one

A: 456-22-4
4-Fluorobenzoic acid

B: 100-09-4
4-methoxybenzoic acid

Conditions

Conditions	Yield
With oxygen; potassium hydroxide at 20℃; Schlenk technique; chemoselective reaction;	A 95% B 96%

: 67-56-1
methanol

: 100-09-4
4-methoxybenzoic acid

: 121-98-2
methyl 4-methoxybenzoate

Conditions

Conditions	Yield
With sulfuric acid for 4h; Reflux;	100%
With sulfuric acid Fischer-Speier esterification method; Reflux;	100%
With cobalt oxide nanoparticles Co/SBA-15 for 12h; Reflux;	98%

: 64-17-5
ethanol

: 100-09-4
4-methoxybenzoic acid

: 94-30-4
ethyl 4-methoxybenzoate

Conditions

Conditions	Yield
With thionyl chloride at 0 - 40℃; for 14h; Inert atmosphere;	100%
With 4-methyl-morpholine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride for 3h;	93%
With thionyl chloride at 0℃; for 5h; Reflux;	90%

: 100-09-4
4-methoxybenzoic acid

: 100-07-2
4-methoxy-benzoyl chloride

Conditions

Conditions	Yield
With thionyl chloride Reflux;	100%
With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃; for 2h; Reflux;	100%
With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 35℃; for 1h;	100%

: 98-88-4
benzoyl chloride

: 100-09-4
4-methoxybenzoic acid

: 58618-94-3
benzoic 4-methoxybenzoic anhydride

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 0℃; for 1h; Inert atmosphere;	100%
cobalt(II) chloride In dichloromethane; acetonitrile at 40℃;	89%

: 100-09-4
4-methoxybenzoic acid

: 62-53-3
aniline

: 7465-88-5
4-methoxy-N-phenylbenzamide

Conditions

Conditions	Yield
With diphosphorus tetraiodide In tetrachloromethane; dichloromethane Heating;	100%
With dmap; 2-chloro-1-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,12,12,12-henicosafluorododecyl)pyridinium trifluoromethanesulfonate; triethylamine In N,N-dimethyl-formamide at 20℃; for 1h;	100%
With dmap; 2-chloro-1-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,12,12,12-henicosafluorododecyl)pyridinium trifluoromethanesulfonate; triethylamine In N,N-dimethyl-formamide at 20℃; for 1h;	100%

: 100-09-4
4-methoxybenzoic acid

: 701-53-1
p-methoxybenzoyl fluoride

Conditions

Conditions	Yield
With pyridine; hydrogen fluoride; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 3h;	100%
With sodium fluoride; ethanaminium,N-(difluoro-λ4-sulfanylidene)-N-ethyl-,tetrafluoroborate at 20℃; for 24h; Inert atmosphere;	99%
With potassium 2-(difluoro(trifluoromethoxy)methoxy)-2,2-difluoroacetate In acetonitrile at 80℃; for 1h; Schlenk technique; Sealed tube; Inert atmosphere;	95%

: 75-03-6
ethyl iodide

: 100-09-4
4-methoxybenzoic acid

: 94-30-4
ethyl 4-methoxybenzoate

Conditions

Conditions	Yield
With caesium carbonate In acetonitrile for 1.5h; Heating;	100%
With potassium carbonate In N,N-dimethyl-formamide at 50℃;	90%
With 18-crown-6 ether; potassium carbonate In tetrahydrofuran for 21h; Inert atmosphere; Reflux;

: 75-84-3
2,2-dimethyl-propanol-1

: 100-09-4
4-methoxybenzoic acid

: 3581-72-4
neopentyl 4-methoxybenzoate

Conditions

Conditions	Yield
With sulfuric acid In toluene	100%

: 64-04-0
phenethylamine

: 100-09-4
4-methoxybenzoic acid

: 6346-07-2
4-methoxy-N-(2-phenylethyl)benzamide

Conditions

Conditions	Yield
With 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride In methanol at 20℃; for 3h;	100%
With 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride In tetrahydrofuran at 20℃; for 3h; Condensation;	95%
With 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride In tetrahydrofuran for 4h;	94%

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 100-09-4
4-methoxybenzoic acid

: 52898-49-4
4,N-dimethoxy-N-methylbenzamide

Conditions

Conditions	Yield
Stage #1: 4-methoxybenzoic acid With oxalyl dichloride In dichloromethane; N,N-dimethyl-formamide at 0℃; Stage #2: N,O-dimethylhydroxylamine*hydrochloride With triethylamine In dichloromethane; N,N-dimethyl-formamide at 20℃; Further stages.;	100%
Stage #1: 4-methoxybenzoic acid With triethylamine; trichloromethyl chloroformate In dichloromethane at 0℃; Stage #2: N,O-dimethylhydroxylamine*hydrochloride In dichloromethane at 25℃; for 1h;	92%
Stage #1: 4-methoxybenzoic acid With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine In tetrahydrofuran; ethyl acetate at 0 - 5℃; for 0.166667h; Inert atmosphere; Stage #2: N,O-dimethylhydroxylamine*hydrochloride In tetrahydrofuran; ethyl acetate at 0 - 25℃; for 1h; Inert atmosphere;	92%

: 1029720-98-6
ethyl 4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylate

: 100-09-4
4-methoxybenzoic acid

: 1338563-35-1
ethyl 5-(4-methoxybenzoyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylate

Conditions

Conditions	Yield
Stage #1: 4-methoxybenzoic acid With triethylamine; fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate In N,N-dimethyl-formamide for 0.25h; Stage #2: ethyl 4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylate In N,N-dimethyl-formamide at 20℃; for 5h;	100%
With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate

: 188111-79-7
tert-butyl (3R)3-aminopiperidine-1-carboxylate

: 100-09-4
4-methoxybenzoic acid

: (R)-tert-butyl 3-(4-methoxybenzamido)piperidine-1-carboxylate

Conditions

Conditions	Yield
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In 1,4-dioxane; N,N-dimethyl-formamide at 20℃; for 3h;	100%

: 41879-37-2
t-butyldimethylsilyl amine

: 100-09-4
4-methoxybenzoic acid

: tert-butyldimethylsilyl 4-methoxybenzoate

Conditions

Conditions	Yield
In neat (no solvent) at 20℃; for 0.5h; Green chemistry;	100%

: 711-79-5
1-hydroxy-2-acetonaphthone

: 100-09-4
4-methoxybenzoic acid

: 934163-66-3
2-acetylnaphthalen-1-yl 4-methoxybenzoate

Conditions

Conditions	Yield
Stage #1: 4-methoxybenzoic acid With thionyl chloride; N,N-dimethyl-formamide In dichloromethane at 40℃; for 0.666667h; Stage #2: 1-hydroxy-2-acetonaphthone With pyridine In dichloromethane at 60℃; for 1h;	100%
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃;

: 75-59-2
tetramethyl ammoniumhydroxide

: 100-09-4
4-methoxybenzoic acid

: 111536-98-2
tetramethylammonium 4-methoxybenzoate

Conditions

Conditions	Yield
With water In ethanol at 0 - 20℃; for 0.0833333h;	100%

: 10267-21-7
13(S)-labdan-8α,15-diol

: 100-09-4
4-methoxybenzoic acid

: 13(S)-labdan-8α-ol-15-yl 4-methoxybenzoate

Conditions

Conditions	Yield
With dmap; diisopropyl-carbodiimide In dichloromethane at 20℃; Cooling with ice;	100%

: 100-09-4
4-methoxybenzoic acid

: 100-46-9
benzylamine

: 7465-87-4
N-benzyl-4-methoxybenzamide

Conditions

Conditions	Yield
Stage #1: 4-methoxybenzoic acid With 1,3,5-trichloro-2,4,6-triazine; potassium carbonate; triphenylphosphine at 20℃; for 0.166667h; Stage #2: benzylamine at 20℃; for 0.333333h;	99%
Stage #1: 4-methoxybenzoic acid With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 0℃; for 0.166667h; Stage #2: benzylamine In N,N-dimethyl-formamide at 20℃; for 0.916667h; Further stages.;	97%
With 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride In methanol for 3h;	96%

: 100-39-0
benzyl bromide

: 100-09-4
4-methoxybenzoic acid

: 6316-54-7
4-methoxy-benzoic acid benzyl ester

Conditions

Conditions	Yield
With N(Et)4(1+)*(2-pyrrolidone-anion) In N,N-dimethyl-formamide for 1h; Ambient temperature;	99%

: 74684-57-4
1a,9b-dihydro-1H-phenanthro<9,10-b>azirine

: 100-09-4
4-methoxybenzoic acid

: 117608-96-5
4-methoxy-N-(phenanthrene-9-yl)benzamide

Conditions

Conditions	Yield
With dicyclohexyl-carbodiimide In dichloromethane for 3h; Heating;	99%

: 100-09-4
4-methoxybenzoic acid

: 3424-93-9
4-methoxyphenylacetamide

Conditions

Conditions	Yield
Stage #1: 4-methoxybenzoic acid With 1,3,5-trichloro-2,4,6-triazine; potassium carbonate In tetrahydrofuran for 0.0166667h; Milling; Stage #2: With ammonium thiocyanate In tetrahydrofuran for 0.0833333h; Milling;	99%
With pyridine; urea for 0.00833333h; microwave irradiation;	90%
Stage #1: 4-methoxybenzoic acid With thionyl chloride In tetrahydrofuran at 50℃; for 1h; Stage #2: With ammonium hydroxide In tetrahydrofuran at 0℃; for 0.0833333h;	84%

Anisic acid Specification

The Anisic acid with CAS registry number of 100-09-4 is also known as Benzoic acid,4-methoxy-. The IUPAC name is 4-Methoxybenzoic acid. It belongs to product categories of Liquid Crystal intermediates; Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts; Organic Acids; Absolute Configuration Determination (Exciton Chirality CD Method); Enantiomer Excess & Absolute Configuration Determination; Exciton Chirality CD Method (for Hydroxyl Groups); Analytical Chemistry;Benzoic Acids (Building Blocks for Liquid Crystals); Building Blocks for Liquid Crystals; Functional Materials. Its EINECS registry number is 202-818-5. In addition, the formula is C₈H₈O₃ and the molecular weight is 152.15. This chemical is a white powder and soluble in alcohol, ether, chloroform, slightly soluble in water, insoluble in cold water. What's more, it should be sealed in ventilated, cool and dry place away from fore, heat.

Physical properties about Anisic acid are: (1)ACD/LogP: 1.78; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1; (4)ACD/LogD (pH 7.4): -1; (5)ACD/BCF (pH 5.5): 2; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 24; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 3; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 2; (12)Polar Surface Area: 46.53Å²; (13)Index of Refraction: 1.546; (14)Molar Refractivity: 39.861 cm³; (15)Molar Volume: 125.965 cm³; (16)Polarizability: 15.802×10^-24cm³; (17)Surface Tension: 44.9 dyne/cm; (18)Density: 1.208 g/cm³; (19)Flash Point: 115.46 °C; (20)Enthalpy of Vaporization: 54.601 kJ/mol; (21)Boiling Point: 278.305 °C at 760 mmHg; (22)Vapour Pressure: 0.002 mmHg at 25 °C.

Preparation of Anisic acid: it is prepared by reaction of hydroxybenzoic acid with dimethyl sulfate. Equation is as follows:

C₇H₆O₃ + (CH₃)₂SO₄ → C₈H₈O₃

Uses of Anisic acid: it is used as a preservative and raw materials of medicine and fragrance. What's more, it is used to produce 4-methoxy-benzoic acid methyl ester by esterification reaction with methanol. The reaction occurs with reagents 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium Cl, N-methylmorpholine at the temperature of 50 °C for 6 hours. The yield is about 88%.

Anisic acid is uesed to produce 4-methoxy-benzoic acid methyl ester by esterification reaction with methanol.

When you are using this chemical, please be cautious about it. As a chemical, it is irritating to eyes, respiratory system and skin. During using it, wear suitable protective clothing. Avoid contact with skin and eyes. If contact with eyes accidently, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
1. Canonical SMILES: COC1=CC=C(C=C1)C(=O)O
2. InChI: InChI=1S/C8H8O3/c1-11-7-4-2-6(3-5-7)8(9)10/h2-5H,1H3,(H,9,10)
3. InChIKey: ZEYHEAKUIGZSGI-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	subcutaneous	400mg/kg (400mg/kg)		Cesko-Slovenska Farmacie. Vol. 31, Pg. 236, 1982.

Product Name

Anisic acid

Synthetic route

Anisic acid Specification

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