Chloroacetyl chloride supplier

Name
Chloroacetyl chloride
EINECS 201-171-6
CAS No. 79-04-9
Article Data116
CAS DataBase
Density 1.386 g/cm³
Solubility Reacts with water
Melting Point -22 °C(lit.)
Formula C₂H₂Cl₂O
Boiling Point 106 °C at 760 mmHg
Molecular Weight 112.943
Flash Point 34 °C
Transport Information UN 1752 6.1/PG 1
Appearance clear colorless liquid
Safety 9-26-36/37/39-45-61-7/8
Risk Codes 14-23/24/25-35-48/23-50
Molecular Structure
Hazard Symbols T,N,C
Synonyms Chloroethanoylchloride;Acetylchloride, chloro- (6CI,8CI,9CI);Chloroacetic acidchloride;Chloroacetic chloride;Monochloroacetyl chloride;
PSA 17.07000
LogP 0.99060

Synthetic route

: 27843-27-2
2-chloro-3,3-dimethyl-1-butene

A: 4707-95-3
tert-butyl phosphinyl dichloride

B: 79-04-9
chloroacetyl chloride

C phosphoryl chloride: phosphoryl chloride

Conditions

Conditions	Yield
With oxygen; phosphorus trichloride at -10 - 10℃;	A 90% B n/a C n/a
With oxygen; phosphorus trichloride at -10 - 10℃; Product distribution; Mechanism;	A 90% B n/a C n/a

...Expand

: 75-36-5
acetyl chloride

: 79-04-9
chloroacetyl chloride

Conditions

Conditions	Yield
With chlorine at 55℃; under 750.075 - 1500.15 Torr; Temperature;	89.59%
With chlorine im Sonnenlicht;
With iodine durch Chlorieren;
With tetrachloromethane; chlorine Irradiation.im Licht der Quarzlampe;

: 79-11-8
chloroacetic acid

: 79-04-9
chloroacetyl chloride

Conditions

Conditions	Yield
With thionyl chloride In N,N-dimethyl-formamide at 20℃; for 24h;	70%
With phosphorus trichloride
With thionyl chloride

: 173063-66-6
cis/trans-3,5-Bis-(chloromethyl)-3-fluoro-5-methyl-1,2,4-trioxolane

A: 78-95-5
chloroacetone

B: 79-04-9
chloroacetyl chloride

C: Chloro-acetic acid 1,2-dichloro-1-methyl-ethyl ester

Conditions

Conditions	Yield
With triphenylphosphine In chloroform-d1	A 28 % Spectr. B 23 % Spectr. C 33%

...Expand

: 463-51-4
Ketene

: 79-04-9
chloroacetyl chloride

Conditions

Conditions	Yield
With nitrosylchloride
With chlorine in der Gasphase;
With tetrachloromethane; chlorine
With sulfur dioxide; chlorine
With diethyl ether; chlorine

: 463-51-4
Ketene

A: 79-36-7
dichloroacethyl chloride

B: 79-04-9
chloroacetyl chloride

Conditions

Conditions	Yield
With chlorine in der Gasphase;

: 463-51-4
Ketene

A: 6061-03-6
nitroacetyl chloride

B: 79-04-9
chloroacetyl chloride

Conditions

Conditions	Yield
With diethyl ether; Nitryl chloride Kuehlung mit CO2-Alkohol;

: 540-59-0
1,2-Dichloroethylene

: 79-04-9
chloroacetyl chloride

Conditions

Conditions	Yield
With sulfuric acid; oxygen
With bromine; oxygen

: 75-35-4
1,1-Dichloroethylene

: 79-04-9
chloroacetyl chloride

Conditions

Conditions	Yield
With tetrachloromethane; oxygen; chlorine Irradiation.unter UV-Bestrahlung;
With oxygen; chlorine Irradiation.unter UV-Bestrahlung , ohne Loesungsmittel;
With oxygen; chlorine; chloroacetyl chloride Irradiation.unter UV-Bestrahlung;

: 42345-82-4
(E)-1,2-dichloro-1-ethoxy-ethene

: 79-04-9
chloroacetyl chloride

Conditions

Conditions	Yield
With hydrogenchloride und nachtraegliches Erhitzen;
With hydrogenchloride

: 13398-09-9
1,1-dichloroethyl chloroacetate

A: 107-20-0
2-chloroethanal

B: 79-04-9
chloroacetyl chloride

Conditions

Conditions	Yield
Spaltung;

: 98-07-7
Benzotrichlorid

: 5435-44-9, 22243-66-9
(E)-3-Ureido-but-2-enoic acid ethyl ester

: 79-11-8
chloroacetic acid

A: 98-88-4
benzoyl chloride

B: 79-04-9
chloroacetyl chloride

Conditions

Conditions	Yield
at 80 - 90℃;

...Expand

: 98-07-7
Benzotrichlorid

: 79-11-8
chloroacetic acid

A: 98-88-4
benzoyl chloride

B: 79-04-9
chloroacetyl chloride

Conditions

Conditions	Yield
at 100 - 120℃;

...Expand

: 98-07-7
Benzotrichlorid

: 79-11-8
chloroacetic acid

: 79-04-9
chloroacetyl chloride

Conditions

Conditions	Yield
at 100 - 120℃;
With zinc(II) chloride at 80 - 90℃;

: 75-44-5
phosgene

: 79-11-8
chloroacetic acid

: 79-04-9
chloroacetyl chloride

Conditions

Conditions	Yield
With pyrographite at 200℃;
With anionenexchanger at 150℃;

: 79-37-8
oxalyl dichloride

: 79-11-8
chloroacetic acid

: 79-04-9
chloroacetyl chloride

: 79-37-8
oxalyl dichloride

: 541-88-8
Chloroacetic anhydride

: 79-04-9
chloroacetyl chloride

: 75-18-3
dimethylsulfide

: 3,5-Dichloro-3,5-bis-chloromethyl-[1,2,4]trioxolane

A: 107-20-0
2-chloroethanal

B: 2373-51-5
chloro-methylsulfanyl-methane

C: 79-11-8
chloroacetic acid

D: 79-04-9
chloroacetyl chloride

Conditions

Conditions	Yield
In chloroform-d1 Ambient temperature;	A 10 % Spectr. B 35 % Spectr. C 31 % Spectr. D 25 % Spectr.

...Expand

: 75-36-5
acetyl chloride

: 79-11-8
chloroacetic acid

A: 64-19-7
acetic acid

B: 79-04-9
chloroacetyl chloride

Conditions

Conditions	Yield
In various solvent(s) at 39.9℃; Equilibrium constant; Kinetics; Thermodynamic data; var. temp.; activation energy E;

...Expand

: 102099-45-6
(dichloroacetyl)methylphenylphosphane

A: 79-36-7
dichloroacethyl chloride

B: 79-04-9
chloroacetyl chloride

C: 15849-86-2, 540513-01-7
methyl(phenyl)chlorophosphine

Conditions

Conditions	Yield
at 0 - 35℃; for 4h; Mechanism; var. time, with solv.; other chloroacetylphosphanes;

...Expand

: 173063-63-3
3-Chlor-3,5-bis(chlormethyl)-1,2,4-trioxolan

A: 79-11-8
chloroacetic acid

B: 79-04-9
chloroacetyl chloride

Conditions

Conditions	Yield
In chloroform-d1 at 41℃; for 312h;	A 61 % Spectr. B 38 % Spectr.

: 173063-66-6
cis/trans-3,5-Bis-(chloromethyl)-3-fluoro-5-methyl-1,2,4-trioxolane

A: 79-43-6
dichloro-acetic acid

B: 75-36-5
acetyl chloride

C: 79-04-9
chloroacetyl chloride

D: 5-Chlor-2-(chlormethyl)-2-methyl-1,3-dioxolan-4-on

Conditions

Conditions	Yield
With 1,1,2,2-tetrachloroethane In chloroform-d1 at 23℃; for 240h;	A 15 % Spectr. B 25 % Spectr. C 8 % Spectr. D 9 % Spectr.

...Expand

: 153940-11-5
(Chloracetyl)(1,2-dichlor-1-methylethyl)peroxid

A: 78-95-5
chloroacetone

B: 79-04-9
chloroacetyl chloride

Conditions

Conditions	Yield
With triphenylphosphine In chloroform-d1 Ambient temperature;	A 54 % Spectr. B 42 % Spectr.

: 3,5-Dichloro-3,5-bis-chloromethyl-[1,2,4]trioxolane

A: 107-20-0
2-chloroethanal

B: 2373-51-5
chloro-methylsulfanyl-methane

C: 79-11-8
chloroacetic acid

D: 79-04-9
chloroacetyl chloride

Conditions

Conditions	Yield
With dimethylsulfide In chloroform-d1 Ambient temperature;	A 10 % Spectr. B 35 % Spectr. C 31 % Spectr. D 25 % Spectr.

...Expand

: 3,5-Dichloro-3,5-bis-chloromethyl-[1,2,4]trioxolane

A: 79-43-6
dichloro-acetic acid

B: 79-36-7
dichloroacethyl chloride

C: 79-11-8
chloroacetic acid

D: 79-04-9
chloroacetyl chloride

Conditions

Conditions	Yield
In chloroform-d1 at 60℃; for 168h;	A 9 % Spectr. B 8 % Spectr. C 22 % Spectr. D 60 % Spectr.

...Expand

: 64-19-7
acetic acid

: 79-04-9
chloroacetyl chloride

Conditions

Conditions	Yield
With hydrogenchloride; N-chloro-succinimide; thionyl chloride; acetic acid 1.) 70 deg C, 30 min, 2.) 85 deg C, 90 min; Yield given. Multistep reaction;

: 107-06-2
1,2-dichloro-ethane

A: 2565-30-2
formyl chloride

B: 124-38-9
carbon dioxide

C: 79-04-9
chloroacetyl chloride

Conditions

Conditions	Yield
With oxygen; chlorine In gas at 22.9℃; under 700 Torr; Rate constant; Irradiation; pulse radiolysis;

...Expand

: 156-60-5
trans-1,2-dichloroethylene

A: 64-18-6
formic acid

B: 2565-30-2
formyl chloride

C: 79-04-9
chloroacetyl chloride

Conditions

Conditions	Yield
With water; oxygen for 0.0152778h; Quantum yield; Decomposition; UV-irradiation;

...Expand

: 75-01-4
chloroethylene

A: 107-20-0
2-chloroethanal

B: 2565-30-2
formyl chloride

C: 79-04-9
chloroacetyl chloride

D: 74-86-2
acetylene

Conditions

Conditions	Yield
With oxygen for 0.0152778h; Quantum yield; Decomposition; UV-irradiation;

...Expand

: 75-35-4
1,1-Dichloroethylene

A: 64-18-6
formic acid

B: 2565-30-2
formyl chloride

C: 79-04-9
chloroacetyl chloride

Conditions

Conditions	Yield
With water; oxygen for 0.00833333h; Quantum yield; Decomposition; UV-irradiation;

...Expand

: 123-75-1
pyrrolidine

: 79-04-9
chloroacetyl chloride

: 20266-00-6
chloroacetic acid pyrrolidide

Conditions

Conditions	Yield
In acetone at 20℃;	100%
In tetrahydrofuran at 0 - 20℃; for 3.5h;	99%
In tetrahydrofuran at 20℃; for 12h; Acylation;	98%

: 110-89-4
piperidine

: 79-04-9
chloroacetyl chloride

: 1440-60-4
1-chloroacetyl-piperidine

Conditions

Conditions	Yield
In acetone at 20℃;	100%
With triethylamine In dichloromethane at 0 - 10℃; for 1h;	100%
With triethylamine In dichloromethane at 0 - 20℃; for 6h;	98%

: 110-91-8
morpholine

: 79-04-9
chloroacetyl chloride

: 1440-61-5
N-chloroacetylmorpholine

Conditions

Conditions	Yield
With potassium carbonate In toluene at 60℃; for 2h;	100%
Stage #1: morpholine; chloroacetyl chloride With triethylamine In dichloromethane at 0 - 27℃; for 2h; Stage #2: With hydrogenchloride In dichloromethane; water	100%
With triethylamine In dichloromethane at 0 - 20℃; for 6h;	99%

: 4795-29-3
TETRAHYDROFURFURYLAMINE

: 79-04-9
chloroacetyl chloride

: 39089-62-8
2-chloro-N-[(tetrahydrofuran-2-yl)methyl]acetamide

Conditions

Conditions	Yield
In dichloromethane	100%
With potassium carbonate In dichloromethane Heating;	97%
With trimethylamine In dichloromethane at 0 - 20℃; for 4h;	76%

: 496-15-1
1-indoline

: 79-04-9
chloroacetyl chloride

: 17133-48-1
2-Chloro-1-(2,3-dihydro-1H-1-indolyl)-1-ethanone

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 3h;	100%
With N,N-dimethyl acetamide at 0℃; for 0.0833333h; Green chemistry;	89%
In acetone at 0 - 20℃; for 1h;	63%

: 61-54-1
tryptamine

: 79-04-9
chloroacetyl chloride

: 52191-26-1
2-chloro-N-<2-(indol-3-yl)ethyl>acetamide

Conditions

Conditions	Yield
With potassium carbonate In dichloromethane Ambient temperature;	100%
In dichloromethane	100%
With triethylamine In tetrahydrofuran at 20℃; for 6h; Cooling with ice; Inert atmosphere;	96%

: 78-81-9
isobutylamine

: 79-04-9
chloroacetyl chloride

: 32461-83-9
2-chloro-N-isobutylacetamide

Conditions

Conditions	Yield
In acetone at 20℃;	100%
With potassium carbonate In dichloromethane at 20℃; Cooling with ice;	73%
With potassium carbonate In dichloromethane at 20℃; Cooling with ice;	73.1%

: 554-00-7
2,4-Dichloroaniline

: 79-04-9
chloroacetyl chloride

: 6974-56-7
2-chloro-N-(2,4-dichlorophenyl)acetamide

Conditions

Conditions	Yield
Stage #1: 2,4-Dichloroaniline With triethylamine In dichloromethane at 20℃; for 0.5h; Stage #2: chloroacetyl chloride In dichloromethane at 0℃;	100%
With triethylamine In dichloromethane at 0 - 25℃;	99.4%
With triethylamine In dichloromethane at 0 - 25℃;	99.4%

: 108-91-8
cyclohexylamine

: 79-04-9
chloroacetyl chloride

: 23605-23-4
2-Chloro-N-cyclohexylacetamide

Conditions

Conditions	Yield
In dichloromethane	100%
With triethylamine In dichloromethane at 20 - 27℃; for 1h;	100%
In acetonitrile at 5 - 20℃; for 2h;	93%

: 104-94-9
4-methoxy-aniline

: 79-04-9
chloroacetyl chloride

: 22303-36-2
N-(4-methoxyphenyl)-2-chloroacetamide

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 0℃; for 0.166667h;	100%
In tetrahydrofuran at 20℃; for 18h;	100%
With triethylamine In dichloromethane at 0 - 25℃;	99.4%

: 120-20-7
2-(3,4-dimethoxyphenyl)-ethylamine

: 79-04-9
chloroacetyl chloride

: 14301-31-6
2-chloro-N-(2-(3,4-dimethoxyphenyl)ethyl)acetamide

Conditions

Conditions	Yield
In dichloromethane	100%
With N,N-dimethyl-aniline In dichloromethane at 0℃; for 1h;	98%
With N,N-dimethyl-aniline In dichloromethane at 0℃; for 2h;	98%

: 64-04-0
phenethylamine

: 79-04-9
chloroacetyl chloride

: 13156-95-1
2-chloro-N-phenethylacetamide

Conditions

Conditions	Yield
With potassium carbonate In dichloromethane Ambient temperature;	100%
With potassium carbonate In dichloromethane at 20℃; Acylation;	100%
In dichloromethane	100%

: 122-39-4
diphenylamine

: 79-04-9
chloroacetyl chloride

: 5428-43-3
2-chloro-N,N-diphenylacetamide

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 20℃; for 0.333333h;	100%
In toluene at 90℃; for 4h; Inert atmosphere;	99%
In N,N-dimethyl-formamide at 80℃; for 2h;	97%

: 109-89-7
diethylamine

: 79-04-9
chloroacetyl chloride

: 2315-36-8
2-Chloro-N,N-diethylacetamide

Conditions

Conditions	Yield
In dichloromethane; water at 5℃; Temperature; Solvent;	100%
With triethylamine In dichloromethane at 0℃;	99%
With triethylamine In 1,2-dichloro-ethane at 10 - 20℃; for 3h; Cooling with ice;	95%

: 5344-90-1
2-Aminobenzyl alcohol

: 79-04-9
chloroacetyl chloride

: 189940-09-8
[2-(2-chloro-acetylamino)-phenyl]-methanol

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 2h;	100%
With diethyl ether; benzene
With triethylamine In tetrahydrofuran	75.9 g (93%)
With triethylamine In tetrahydrofuran	75.9 g (93%)
With triethylamine In tetrahydrofuran	75.9 g (93%)

: 107-10-8
propylamine

: 79-04-9
chloroacetyl chloride

: 13916-39-7
N-(propyl)chloroacetamide

Conditions

Conditions	Yield
In dichloromethane	100%
In dichloromethane at 0℃; for 1h; Inert atmosphere;	100%
In dichloromethane for 1h; Cooling with ice; Inert atmosphere;	99%

: 60-15-1, 156-34-3, 51-64-9, 300-62-9
2-amino-1-phenylpropane

: 79-04-9
chloroacetyl chloride

: 13156-94-0
(+/-)-chloroacetic acid-(1-methyl-2-phenyl-ethylamide)

Conditions

Conditions	Yield
With potassium carbonate In dichloromethane Ambient temperature;	100%

: 2216-51-5
(-)-menthol

: 79-04-9
chloroacetyl chloride

: 7377-98-2, 27994-88-3, 88644-14-8, 106916-72-7, 111957-92-7, 21758-29-2
(-)-menthyl chloroacetate

Conditions

Conditions	Yield
In benzene Heating;	100%
With dmap; triethylamine In dichloromethane at 0 - 20℃; for 12h; Temperature;	98.8%
With pyridine In dichloromethane at 0 - 20℃; for 1.33333h; Inert atmosphere;	98%

: 79-04-9
chloroacetyl chloride

: 62-53-3
aniline

: 587-65-5
N-chloroacetyl-aniline

Conditions

Conditions	Yield
With dmap; triethylamine In dichloromethane at 0 - 20℃; Inert atmosphere;	100%
With potassium carbonate In acetone at 20℃; for 4h;	98%
With triethylamine In dichloromethane at 15℃; for 0.25h;	98.55%

: 79-04-9
chloroacetyl chloride

: 108-42-9
3-chloro-aniline

: 2564-05-8
2-chloro-N-(3-chlorophenyl)acetamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 25℃;	100%
With triethylamine In dichloromethane at 0 - 25℃;	100%
In tetrahydrofuran at 20℃; for 18h;	100%

: 79-04-9
chloroacetyl chloride

: 626-43-7
3,5-Dichloroaniline

: 33560-48-4
2-chloro-N-(3,5-dichlorophenyl)acetamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 25℃;	100%
With triethylamine In dichloromethane at 0 - 25℃;	100%
With triethylamine In dichloromethane at 20℃; for 5h;	99%

: 79-04-9
chloroacetyl chloride

: 100-46-9
benzylamine

: 2564-06-9
N-benzyl-2-chloroacetamide

Conditions

Conditions	Yield
In dichloromethane	100%
With triethylamine In dichloromethane at 0 - 20℃; for 4h; Inert atmosphere;	98%
With potassium carbonate In dichloromethane Heating;	97%

: 79-04-9
chloroacetyl chloride

: 371-40-4
4-fluoroaniline

: 351-04-2
2-chloro-N-(4-fluorophenyl)acetamide

Conditions

Conditions	Yield
In ethyl acetate for 3h; Heating;	100%
With potassium hydrogencarbonate In Isopropyl acetate; water at 0 - 20℃; for 0.5h;	95%
With triethylamine In dichloromethane at 0 - 20℃; for 5h; Inert atmosphere;	95%

: 79-04-9
chloroacetyl chloride

: 114-83-0
1-acetyl-2-phenylhydrazine

: 108511-46-2
2-acetyl-1-(2-chloroacetyl)phenylhydrazine

Conditions

Conditions	Yield
In dichloromethane for 0.5h;	100%
With benzene

: 79-04-9
chloroacetyl chloride

: 2039-67-0
2-(3-methoxyphenyl)-1-ethanamine

: 34162-12-4
N-chloroacetyl-N-(2-(3-methoxy-phenyl)-ethyl)-amine

Conditions

Conditions	Yield
With potassium carbonate In dichloromethane Ambient temperature;	100%
With sodium hydrogencarbonate In dichloromethane at 0 - 20℃; for 2h;	93%
With triethylamine In dichloromethane at 0 - 20℃; for 2h;	73%

: 79-04-9
chloroacetyl chloride

: 122-09-8
Phentermin

: 26187-18-8
2-chloro-N-(2-methyl-1-phenylpropan-2-yl)acetamide

Conditions

Conditions	Yield
With potassium carbonate In dichloromethane Ambient temperature;	100%

: 2536-91-6
6-methylbenzothiazol-2-ylamine

: 79-04-9
chloroacetyl chloride

: 3174-15-0
2-chloro-N-(6-methylbenzothiazol-2-yl)acetamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃;	100%
Stage #1: 6-methylbenzothiazol-2-ylamine With pyridine In benzene at 0 - 5℃; for 0.5h; Stage #2: chloroacetyl chloride In benzene for 2h;	92%
With triethylamine In chloroform at 20℃; for 2h;	91%

: 2103-99-3
4-(4-chlorophenyl)-2-thiazolamine

: 79-04-9
chloroacetyl chloride

: 6125-31-1
2-chloro-N-[4-(4-chlorophenyl)-1,3-thiazol-2-yl]acetamide

Conditions

Conditions	Yield
Stage #1: 4-(4-chlorophenyl)-2-thiazolamine With triethylamine In dichloromethane at 0 - 5℃; for 0.5h; Stage #2: chloroacetyl chloride In dichloromethane at 0 - 20℃; for 2h;	100%
With pyridine for 6.5h;	81%
In benzene for 3h; Reflux;	65%

: 30433-91-1
[2-(2-thyenyl)ethyl]amine

: 79-04-9
chloroacetyl chloride

: 135709-69-2
2-chloro-N-(2-(thiophen-2-yl)ethyl)acetamide

Conditions

Conditions	Yield
With potassium carbonate In dichloromethane Ambient temperature;	100%
With triethylamine In dichloromethane at 0℃;	82%
In benzene at 0℃; Reflux;

: 59311-67-0
2-(3-thienyl)ethylamine

: 79-04-9
chloroacetyl chloride

: 135709-70-5
2-chloro-N-(2-(thiophen-3-yl)ethyl)acetamide

Conditions

Conditions	Yield
With potassium carbonate In dichloromethane Ambient temperature;	100%
With triethylamine In dichloromethane at 0℃;	2.2 g

Chloroacetyl chloride Specification

The Chloroacetyl chloride, with the CAS registry number 79-04-9 and EINECS registry number 201-171-6, has the systemtic name of chloroacetyl chloride. It is a kind of clear colourless liquid, and belongs to the following product categories: Pharmaceutical Intermediates; Halogen compounds; Organics; Acid Halides; Carbonyl Compounds; Organic Building Blocks. And the molecular formula of this chemical is C₂H₂Cl₂O.

The physical properties of Chloroacetyl chloride are as followings: (1)ACD/LogP: 0.69; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 0.69; (4)ACD/LogD (pH 7.4): 0.69; (5)ACD/BCF (pH 5.5): 1.97; (6)ACD/BCF (pH 7.4): 1.97; (7)ACD/KOC (pH 5.5): 56.51; (8)ACD/KOC (pH 7.4): 56.51; (9)#H bond acceptors: 1; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 1; (12)Polar Surface Area: 17.07 Å²; (13)Index of Refraction: 1.43; (14)Molar Refractivity: 21.04 cm³; (15)Molar Volume: 81.4 cm³; (16)Polarizability: 8.34×10^-24cm³; (17)Surface Tension: 31.9 dyne/cm; (18)Density: 1.386 g/cm³; (19)Flash Point: 34 °C; (20)nthalpy of Vaporization: 34.49 kJ/mol; (21)Boiling Point: 106 °C at 760 mmHg; (22)Vapour Pressure: 28.8 mmHg at 25°C.

Preparation and uses: It can be produced by the carbonylation of methylene chloride, oxidation of vinylidene chloride, or the addition of chlorine to ketene in industrial. And it may also be prepared from chloroacetic acid and thionyl chloride, phosphorus pentachloride, or phosgene. It is usually used as an intermediate in the production of alachlor and butachlor, and it is also used as a tear gas.

You should be cautious while dealing with this chemical. It reacts violently with water, and toxic by inhalation, in contact with skin and if swallowed. It may cause severe burns, and has risk of serious damage to health by prolonged exposure through inhalation. It is also very toxic to aquatic organisms. Therefore, you had better take the following instructions: Keep container in a well-ventilated place; Wear suitable protective clothing, gloves and eye/face protection, and in case of contacting with eyes, rinse immediately with plenty of water and seek medical advice; In case of accident or if you feel unwell, seek medical advice immediately (show label where possible); Keep container tightly closed and dry; Avoid release to the environment. Refer to special instructions safety data sheet.

You can still convert the following datas into molecular structure:
(1)SMILES: C(C(=O)Cl)Cl
(2)InChI: InChI=1S/C2H2Cl2O/c3-1-2(4)5/h1H2
(3)InChIKey: VGCXGMAHQTYDJK-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LC50	inhalation	1300ppm/2H (1300ppm)		"Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986Vol. 5, Pg. 123(89), 1986.
mouse	LD50	intravenous	32mg/kg (32mg/kg)		U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#04538,
mouse	LD50	oral	220mg/kg (220mg/kg)		Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 54(2), Pg. 90, 1989.
rabbit	LDLo	skin	316mg/kg (316mg/kg)		"Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986Vol. 5, Pg. 123(89), 1986.
rat	LC50	inhalation	660ppm/1H (660ppm)		National Technical Information Service. Vol. OTS0555574,
rat	LD50	oral	208mg/kg (208mg/kg)		"Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986Vol. 5, Pg. 123(89), 1986.
rat	LD50	skin	662mg/kg (662mg/kg)	SKIN AND APPENDAGES (SKIN): CORROSIVE: AFTER TOPICAL EXPOSURE	Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 54(2), Pg. 90, 1989.

Product Name

Chloroacetyl chloride

Synthetic route

Chloroacetyl chloride Specification

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