Product Name

  • Name

    Chloromethyltrimethylsilane

  • EINECS 219-058-5
  • CAS No. 2344-80-1
  • Article Data33
  • CAS DataBase
  • Density 0.865 g/cm3
  • Solubility Insoluble in water
  • Melting Point < 0 °C
  • Formula C4H11ClSi
  • Boiling Point 96 °C at 760 mmHg
  • Molecular Weight 122.67
  • Flash Point 27°F
  • Transport Information UN 1993 3/PG 2
  • Appearance clear colorless liquid
  • Safety 16-26-36-29-37/39-33
  • Risk Codes 11-36/37/38-34
  • Molecular Structure Molecular Structure of 2344-80-1 (Chloromethyltrimethylsilane)
  • Hazard Symbols FlammableF,IrritantXi,CorrosiveC
  • Synonyms (Chloromethyl)trimethylsilane;(Trimethylsilyl)methyl chloride;Trimethyl(chloromethyl)silane;
  • PSA 0.00000
  • LogP 2.52090

Synthetic route

chloro-trimethyl-silane
75-77-4

chloro-trimethyl-silane

dichloromethane
75-09-2

dichloromethane

A

bis(trimethylsilyl)methane
2117-28-4

bis(trimethylsilyl)methane

B

Chloromethyltrimethylsilane
2344-80-1

Chloromethyltrimethylsilane

Conditions
ConditionsYield
With N,N,N,N-tetraethylammonium tetrafluoroborate In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide for 18.4167h; electroreduction, anode: Al, cathode: stainless steel;A 10%
B 90%
Chloro(chloromethyl)dimethylsilane
1719-57-9

Chloro(chloromethyl)dimethylsilane

Chloromethyltrimethylsilane
2344-80-1

Chloromethyltrimethylsilane

Conditions
ConditionsYield
With methylmagnesium bromide In not given90%
With CH3MgBr In not given90%
chloro-trimethyl-silane
75-77-4

chloro-trimethyl-silane

dichloromethane
75-09-2

dichloromethane

A

bis(trimethylsilyl)methane
2117-28-4

bis(trimethylsilyl)methane

B

1,2-bis(trimethylsilyl)ethane
6231-76-1

1,2-bis(trimethylsilyl)ethane

C

Chloromethyltrimethylsilane
2344-80-1

Chloromethyltrimethylsilane

Conditions
ConditionsYield
With N,N,N,N-tetraethylammonium tetrafluoroborate In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide for 33.5h; electroreduction, anode: Al, cathode: stainless steel;A 88%
B 6%
C 6%
tetramethylsilane
75-76-3

tetramethylsilane

chlorine
7782-50-5

chlorine

Chloromethyltrimethylsilane
2344-80-1

Chloromethyltrimethylsilane

Conditions
ConditionsYield
In neat (no solvent, gas phase) vapor phase chlorination at temp. of boiling benzene;;74%
In tetrachloromethane Irradiation (UV/VIS); introduction of gaseous Cl2 into a soln. of Si(CH3)4 in CCl4 under irradiation with sunlight in presence of some PCl5;;33%
Chloro(chloromethyl)dimethylsilane
1719-57-9

Chloro(chloromethyl)dimethylsilane

methylmagnesium bromide
75-16-1

methylmagnesium bromide

Chloromethyltrimethylsilane
2344-80-1

Chloromethyltrimethylsilane

Conditions
ConditionsYield
42%
With diethyl ether
tetramethylsilane
75-76-3

tetramethylsilane

Chloro(chloromethyl)dimethylsilane
1719-57-9

Chloro(chloromethyl)dimethylsilane

Chloromethyltrimethylsilane
2344-80-1

Chloromethyltrimethylsilane

Conditions
ConditionsYield
aluminium trichloride In tetrachloromethane for 6h; Heating; atmospheric pressure;33%
tetramethylsilane
75-76-3

tetramethylsilane

Chloro(chloromethyl)dimethylsilane
1719-57-9

Chloro(chloromethyl)dimethylsilane

A

chloro-trimethyl-silane
75-77-4

chloro-trimethyl-silane

B

Chloromethyltrimethylsilane
2344-80-1

Chloromethyltrimethylsilane

Conditions
ConditionsYield
aluminium trichloride In neat (no solvent) at 30 - 40℃; for 19h; Product distribution; atmospheric pressure; other time and solvents, different ratio of the starting materials;A n/a
B 32%
tetramethylsilane
75-76-3

tetramethylsilane

A

methanesulfonyl trimethylsilyl chloride
18143-34-5

methanesulfonyl trimethylsilyl chloride

B

Chloromethyltrimethylsilane
2344-80-1

Chloromethyltrimethylsilane

Conditions
ConditionsYield
With yttrium(III) chloride; sulfuryl dichloride for 8h; Irradiation;A 20%
B 20%
methyl magnesium iodide
917-64-6

methyl magnesium iodide

(chloromethyl)trichlorosilane
1558-25-4

(chloromethyl)trichlorosilane

Chloromethyltrimethylsilane
2344-80-1

Chloromethyltrimethylsilane

methyl magnesium iodide
917-64-6

methyl magnesium iodide

(chloromethyl)trichlorosilane
1558-25-4

(chloromethyl)trichlorosilane

A

iodo(trimethylsilyl)methane
4206-67-1

iodo(trimethylsilyl)methane

B

Chloromethyltrimethylsilane
2344-80-1

Chloromethyltrimethylsilane

diethyl ether
60-29-7

diethyl ether

Chloro(chloromethyl)dimethylsilane
1719-57-9

Chloro(chloromethyl)dimethylsilane

methylmagnesium chloride
676-58-4

methylmagnesium chloride

Chloromethyltrimethylsilane
2344-80-1

Chloromethyltrimethylsilane

tetramethylsilane
75-76-3

tetramethylsilane

Chloromethyltrimethylsilane
2344-80-1

Chloromethyltrimethylsilane

Conditions
ConditionsYield
With tetrachloromethane; phosphorus pentachloride; chlorine unter Belichtung;
With tetrachloromethane; potassium carbonate; acetonitrile; bis(triphenylphosphine)platinum(II) dichloride at 120℃; for 16h;2.4 % Chromat.
(chloromethyl)trichlorosilane
1558-25-4

(chloromethyl)trichlorosilane

methylmagnesium bromide
75-16-1

methylmagnesium bromide

Chloromethyltrimethylsilane
2344-80-1

Chloromethyltrimethylsilane

methyl magnesium iodide
917-64-6

methyl magnesium iodide

chloromethylmethyldichlorosilane
1558-33-4

chloromethylmethyldichlorosilane

Chloromethyltrimethylsilane
2344-80-1

Chloromethyltrimethylsilane

chloromethyldimethylsilane
3144-74-9

chloromethyldimethylsilane

methyl magnesium iodide
917-64-6

methyl magnesium iodide

Chloromethyltrimethylsilane
2344-80-1

Chloromethyltrimethylsilane

n-Butyl chloride
109-69-3

n-Butyl chloride

(bromomethyl)trimethylsilane
18243-41-9

(bromomethyl)trimethylsilane

A

1-bromo-butane
109-65-9

1-bromo-butane

B

Chloromethyltrimethylsilane
2344-80-1

Chloromethyltrimethylsilane

Conditions
ConditionsYield
With triisooctyl amine Equilibrium constant;
n-Butyl chloride
109-69-3

n-Butyl chloride

iodo(trimethylsilyl)methane
4206-67-1

iodo(trimethylsilyl)methane

A

1-iodo-butane
542-69-8

1-iodo-butane

B

Chloromethyltrimethylsilane
2344-80-1

Chloromethyltrimethylsilane

Conditions
ConditionsYield
With triisooctyl amine Equilibrium constant;
trichloromethyltrimethylsilane
5936-98-1

trichloromethyltrimethylsilane

Dilithium N,N'-bis(trimethylsilyl)hydrazide tetramer
15114-92-8, 33509-48-7, 53380-51-1

Dilithium N,N'-bis(trimethylsilyl)hydrazide tetramer

A

chloro-trimethyl-silane
75-77-4

chloro-trimethyl-silane

B

(dichloromethyl)trimethylsilane
5926-38-5

(dichloromethyl)trimethylsilane

C

N,N'-bis(trimethylsilyl)hydrazine
692-56-8

N,N'-bis(trimethylsilyl)hydrazine

D

tris(trimethylsilyl)hydrazine
13272-02-1

tris(trimethylsilyl)hydrazine

E

1,1,1,3,3,3-hexamethyl-disilazane
999-97-3

1,1,1,3,3,3-hexamethyl-disilazane

F

Chloromethyltrimethylsilane
2344-80-1

Chloromethyltrimethylsilane

Conditions
ConditionsYield
In diethyl ether at -78℃; Product distribution; var.: reagent;
tetrachloromethane
56-23-5

tetrachloromethane

tetramethylsilane
75-76-3

tetramethylsilane

phosphorus pentachloride
10026-13-8, 874483-75-7

phosphorus pentachloride

chlorine
7782-50-5

chlorine

Chloromethyltrimethylsilane
2344-80-1

Chloromethyltrimethylsilane

bis(chloromethyl)dimethylsilane
2917-46-6

bis(chloromethyl)dimethylsilane

A

tetramethylsilane
75-76-3

tetramethylsilane

B

Chloromethyltrimethylsilane
2344-80-1

Chloromethyltrimethylsilane

Conditions
ConditionsYield
With Zn In ethanol; water react. of (CH3)2Si(CH2Cl)2 and Zn powder in aq. ethanol in presence of NaI and Na2CO3;;
chloro-trimethyl-silane
75-77-4

chloro-trimethyl-silane

chlorobromomethane
74-97-5

chlorobromomethane

Chloromethyltrimethylsilane
2344-80-1

Chloromethyltrimethylsilane

Conditions
ConditionsYield
With n-butyllithium In tetrahydrofuran; hexane at -78℃;
(dichloromethyl)trimethylsilane
5926-38-5

(dichloromethyl)trimethylsilane

A

chloro-trimethyl-silane
75-77-4

chloro-trimethyl-silane

B

tetramethylsilane
75-76-3

tetramethylsilane

C

Chloromethyltrimethylsilane
2344-80-1

Chloromethyltrimethylsilane

Conditions
ConditionsYield
With hydrogen at 200℃; under 760.051 Torr; for 1h; Kinetics; Flow reactor;
With hydrogen at 200℃; under 760.051 Torr; for 1h; Kinetics; Flow reactor;
(dichloromethyl)trimethylsilane
5926-38-5

(dichloromethyl)trimethylsilane

A

chloro-trimethyl-silane
75-77-4

chloro-trimethyl-silane

B

Chloromethyltrimethylsilane
2344-80-1

Chloromethyltrimethylsilane

Conditions
ConditionsYield
With hydrogen at 200℃; under 760.051 Torr; for 1h; Kinetics; Flow reactor;
benzylamine
100-46-9

benzylamine

Chloromethyltrimethylsilane
2344-80-1

Chloromethyltrimethylsilane

N-benzyl-1-(trimethylsilyl)-N-((trimethylsilyl)methyl)methanamine
144964-17-0

N-benzyl-1-(trimethylsilyl)-N-((trimethylsilyl)methyl)methanamine

Conditions
ConditionsYield
With potassium carbonate In acetonitrile Heating;100%
With potassium carbonate In acetonitrile for 68h; Heating;76%
4,6,6-trimethyl-5,6,7,7a-tetrahydro-1,3-benzodioxol-5-one

4,6,6-trimethyl-5,6,7,7a-tetrahydro-1,3-benzodioxol-5-one

trimethylsilylmethyllithium
1822-00-0

trimethylsilylmethyllithium

Chloromethyltrimethylsilane
2344-80-1

Chloromethyltrimethylsilane

lithium hydride
7580-67-8

lithium hydride

4,6,6-trimethyl-5,6,7,7a-tetrahydro-5-trimethylsilylmethyl-1,3-benzodioxol-5-ol

4,6,6-trimethyl-5,6,7,7a-tetrahydro-5-trimethylsilylmethyl-1,3-benzodioxol-5-ol

Conditions
ConditionsYield
In tetrahydrofuran; water; pentane100%
3-fluorosalicylaldehyde
394-50-3

3-fluorosalicylaldehyde

Chloromethyltrimethylsilane
2344-80-1

Chloromethyltrimethylsilane

3-fluoro-2-((trimethylsilyl)methoxy)benzaldehyde
1346529-53-0

3-fluoro-2-((trimethylsilyl)methoxy)benzaldehyde

Conditions
ConditionsYield
With potassium carbonate; sodium iodide In N,N-dimethyl-formamide at 65℃; for 12h; Inert atmosphere;100%
With potassium carbonate; sodium iodide In N,N-dimethyl-formamide at 65℃;98%
With potassium carbonate; sodium iodide In N,N-dimethyl-formamide at 65℃;
furfural
98-01-1

furfural

Chloromethyltrimethylsilane
2344-80-1

Chloromethyltrimethylsilane

1-(2'-furyl)-2-trimethylsilanylethan-1-ol
1578-26-3

1-(2'-furyl)-2-trimethylsilanylethan-1-ol

Conditions
ConditionsYield
Stage #1: Chloromethyltrimethylsilane With magnesium In diethyl ether at 20℃; for 1h;
Stage #2: furfural In diethyl ether at 0 - 20℃; for 1h;
99%
With magnesium In diethyl ether at 0 - 20℃; for 12h; Grignard reaction;90%
Stage #1: Chloromethyltrimethylsilane With magnesium In diethyl ether for 1h; Grignard reaction; Heating;
Stage #2: furfural In diethyl ether at 0 - 20℃; for 12h; Addition; Further stages.;
90%
Stage #1: Chloromethyltrimethylsilane With magnesium In diethyl ether for 1h; Heating;
Stage #2: furfural In diethyl ether for 12h; Grignard reaction; Further stages.;
90%
Stage #1: Chloromethyltrimethylsilane With 1,1-Dibromoethane; magnesium In diethyl ether for 18h; Heating;
Stage #2: furfural In diethyl ether at 0 - 23℃; for 18h; Grignard reaction;
2-Mercaptopyridine
2637-34-5

2-Mercaptopyridine

Chloromethyltrimethylsilane
2344-80-1

Chloromethyltrimethylsilane

2-(trimethylsilylmethylmercapto)pyridine
151668-58-5

2-(trimethylsilylmethylmercapto)pyridine

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In ethanol for 1h; Heating;98%
thiophene-2-carbaldehyde
98-03-3

thiophene-2-carbaldehyde

Chloromethyltrimethylsilane
2344-80-1

Chloromethyltrimethylsilane

1-(2-thienyl)-2-(trimethylsilyl)ethanol

1-(2-thienyl)-2-(trimethylsilyl)ethanol

Conditions
ConditionsYield
Stage #1: Chloromethyltrimethylsilane With magnesium In diethyl ether at 20℃; for 1h;
Stage #2: thiophene-2-carbaldehyde In diethyl ether at 0 - 20℃; for 1h;
98%
Stage #1: Chloromethyltrimethylsilane With magnesium; ethylene dibromide In diethyl ether for 1h; Heating;
Stage #2: thiophene-2-carbaldehyde In diethyl ether at 0 - 20℃; for 21h;
94%
2-bromo-4,5-dichloro-1 H-imidazole
16076-27-0

2-bromo-4,5-dichloro-1 H-imidazole

Chloromethyltrimethylsilane
2344-80-1

Chloromethyltrimethylsilane

2-bromo-4,5-dichloro-1-[(trimethylsilyl)methyl]-1H-imidazole

2-bromo-4,5-dichloro-1-[(trimethylsilyl)methyl]-1H-imidazole

Conditions
ConditionsYield
With potassium hexamethylsilazane In N,N-dimethyl acetamide at 0 - 100℃; for 4h;98%
Chloromethyltrimethylsilane
2344-80-1

Chloromethyltrimethylsilane

trimethylsilylmethyl azide
87576-94-1

trimethylsilylmethyl azide

Conditions
ConditionsYield
With sodium azide In N,N-dimethyl-formamide at 80℃; for 44h;97%
With N,N,N,N,N,N-hexamethylphosphoric triamide; sodium azide at 80℃; for 12h;95%
With sodium azide In N,N-dimethyl-formamide at 80℃; for 40h; Inert atmosphere;85%
1,8-diazabicyclo[5.4.0]undec-7-ene
6674-22-2

1,8-diazabicyclo[5.4.0]undec-7-ene

Chloromethyltrimethylsilane
2344-80-1

Chloromethyltrimethylsilane

1-(methyl trimethylsilane)-1,8-diazobicyclo[5.4.0]undec-7-ene chloride

1-(methyl trimethylsilane)-1,8-diazobicyclo[5.4.0]undec-7-ene chloride

Conditions
ConditionsYield
In neat (no solvent) at 70℃; for 2h; Inert atmosphere;97%
In N,N-dimethyl-formamide at 100℃; for 20h;95%
(+)-(S)-1-Phenyl-3,4,5,6-tetrahydro[1,2]thiazin-1-oxide
210552-40-2

(+)-(S)-1-Phenyl-3,4,5,6-tetrahydro[1,2]thiazin-1-oxide

Chloromethyltrimethylsilane
2344-80-1

Chloromethyltrimethylsilane

(+)-(1S,6S)-6-(trimethylsilyl)methyl-1-phenyl-3,4,5,6-tetrahydro-1λ4-1,2-thiazine 1-oxide
1305338-61-7

(+)-(1S,6S)-6-(trimethylsilyl)methyl-1-phenyl-3,4,5,6-tetrahydro-1λ4-1,2-thiazine 1-oxide

Conditions
ConditionsYield
Stage #1: (+)-(S)-1-Phenyl-3,4,5,6-tetrahydro[1,2]thiazin-1-oxide With n-butyllithium In tetrahydrofuran; hexane at -50 - 20℃;
Stage #2: Chloromethyltrimethylsilane In tetrahydrofuran; hexane at -78 - 20℃; for 18h; optical yield given as %de; diastereoselective reaction;
97%
Chloro(chloromethyl)dimethylsilane
1719-57-9

Chloro(chloromethyl)dimethylsilane

Chloromethyltrimethylsilane
2344-80-1

Chloromethyltrimethylsilane

chloromethyl(dimethyl)(trimethylsilylmethyl)silane
18306-73-5

chloromethyl(dimethyl)(trimethylsilylmethyl)silane

Conditions
ConditionsYield
Stage #1: Chloromethyltrimethylsilane With magnesium; ethylene dibromide In tetrahydrofuran for 2h; Schlenk technique; Inert atmosphere; Reflux;
Stage #2: Chloro(chloromethyl)dimethylsilane In tetrahydrofuran for 20h; Reflux; Schlenk technique; Inert atmosphere;
97%
tert-butylamine
75-64-9

tert-butylamine

Chloromethyltrimethylsilane
2344-80-1

Chloromethyltrimethylsilane

N-tert-butyl<(trimethylsilyl)metyl>amine
79250-80-9

N-tert-butyl<(trimethylsilyl)metyl>amine

Conditions
ConditionsYield
Stage #1: tert-butylamine; Chloromethyltrimethylsilane at 200℃; for 18h;
Stage #2: With sodium hydroxide In water
96%
at 200℃; for 18h; Product distribution / selectivity; Heating / reflux;96%
Stage #1: tert-butylamine; Chloromethyltrimethylsilane at 200℃; for 18h;
Stage #2: With sodium hydroxide In water at 20℃; for 1h; Product distribution / selectivity;
96%
methyltris(trimethylsilyl)silane
2003-86-3

methyltris(trimethylsilyl)silane

Chloromethyltrimethylsilane
2344-80-1

Chloromethyltrimethylsilane

2-[(trimethylsilyl)methyl]heptamethyltrisilane
1314534-53-6

2-[(trimethylsilyl)methyl]heptamethyltrisilane

Conditions
ConditionsYield
With potassium tert-butylate In tetrahydrofuran Inert atmosphere;96%
Chloromethyltrimethylsilane
2344-80-1

Chloromethyltrimethylsilane

1,4-bis(trimethylsilyl)dodecamethylbicyclo[2.2.2]octasilane
79769-61-2

1,4-bis(trimethylsilyl)dodecamethylbicyclo[2.2.2]octasilane

1-(trimethylsilyl)-4-[(trimethylsilyl)methyl]dodecamethylbicyclo[2.2.2]octasilane
1314534-75-2

1-(trimethylsilyl)-4-[(trimethylsilyl)methyl]dodecamethylbicyclo[2.2.2]octasilane

Conditions
ConditionsYield
Stage #1: 1,4-bis(trimethylsilyl)dodecamethylbicyclo[2.2.2]octasilane With potassium tert-butylate In tetrahydrofuran Inert atmosphere;
Stage #2: Chloromethyltrimethylsilane In tetrahydrofuran at 20℃; for 16.1667h; Cooling with ice; Inert atmosphere;
96%
thiophenol
108-98-5

thiophenol

Chloromethyltrimethylsilane
2344-80-1

Chloromethyltrimethylsilane

(phenylsulfanylmethyl)trimethylsilane
17873-08-4

(phenylsulfanylmethyl)trimethylsilane

Conditions
ConditionsYield
With sodium hydroxide In ethanol; water for 4h; Heating;95%
benzylamine
100-46-9

benzylamine

Chloromethyltrimethylsilane
2344-80-1

Chloromethyltrimethylsilane

N-(trimethylsilylmethyl)benzylamine
53215-95-5

N-(trimethylsilylmethyl)benzylamine

Conditions
ConditionsYield
In dimethyl sulfoxide Heating;95%
at 20 - 120℃; for 24h;93.3%
In acetonitrile for 16h; Reflux; Inert atmosphere;93%
p-Chlorothiophenol
106-54-7

p-Chlorothiophenol

Chloromethyltrimethylsilane
2344-80-1

Chloromethyltrimethylsilane

<(4-chlorophenylthio)methyl>trimethylsilane
112474-70-1

<(4-chlorophenylthio)methyl>trimethylsilane

Conditions
ConditionsYield
With sodium hydroxide In ethanol; water for 4h; Heating;95%
Chloromethyltrimethylsilane
2344-80-1

Chloromethyltrimethylsilane

1,1,1-trichloro-3,3-dimethyl-1,3-disilabutane
16538-62-8

1,1,1-trichloro-3,3-dimethyl-1,3-disilabutane

Conditions
ConditionsYield
With trichlorosilane; tetra-n-butylphosphonium chloride at 150℃; for 4h;95%
With trichlorosilane; benzyltriphenylphosphonium chloride72%
With trichlorosilane; benzyltriphenylphosphonium chloride72%
With tetrachlorosilane; magnesium; methyl iodide 1.) THF, reflux, 0.5 h, 2.) THF, 80 deg C, 4 h; Yield given. Multistep reaction;
2-mercaptobenzimidazole sodium salt
15091-69-7, 26585-65-9

2-mercaptobenzimidazole sodium salt

Chloromethyltrimethylsilane
2344-80-1

Chloromethyltrimethylsilane

2-Trimethylsilanylmethylsulfanyl-1H-benzoimidazole

2-Trimethylsilanylmethylsulfanyl-1H-benzoimidazole

Conditions
ConditionsYield
In benzene for 4h; Heating;95%
(R)-1-phenyl-ethyl-amine
3886-69-9

(R)-1-phenyl-ethyl-amine

Chloromethyltrimethylsilane
2344-80-1

Chloromethyltrimethylsilane

(R)-(+)-N-1-phenylethyl-N-trimethylsilylmethylamine
104942-85-0

(R)-(+)-N-1-phenylethyl-N-trimethylsilylmethylamine

Conditions
ConditionsYield
In dimethyl sulfoxide at 90℃; for 18h;95%
Heating;84%
With potassium carbonate In acetonitrile for 4h; Heating;81%
furan-3-carboxaldehyde
498-60-2

furan-3-carboxaldehyde

Chloromethyltrimethylsilane
2344-80-1

Chloromethyltrimethylsilane

1-furan-3-yl-2-trimethylsilanyl-ethanol

1-furan-3-yl-2-trimethylsilanyl-ethanol

Conditions
ConditionsYield
Stage #1: Chloromethyltrimethylsilane With magnesium In diethyl ether Heating;
Stage #2: furan-3-carboxaldehyde In diethyl ether at 0 - 20℃; for 12h; Further stages.;
95%
Stage #1: Chloromethyltrimethylsilane With 1,1-Dibromoethane; magnesium In diethyl ether for 19h; Heating;
Stage #2: furan-3-carboxaldehyde In diethyl ether at 0 - 23℃; for 18h; Grignard reaction;
1-methyl-4-((phenylsulfonyl)methyl)benzene
19523-24-1

1-methyl-4-((phenylsulfonyl)methyl)benzene

Chloromethyltrimethylsilane
2344-80-1

Chloromethyltrimethylsilane

(2-benzenesulfonyl-2-p-tolyl-ethyl)-trimethyl-silane

(2-benzenesulfonyl-2-p-tolyl-ethyl)-trimethyl-silane

Conditions
ConditionsYield
With lithium methylsulfinyl carbanion at 20℃; for 2h; Product distribution; Further Variations:; Reagents; Temperatures;95%
Chloromethyltrimethylsilane
2344-80-1

Chloromethyltrimethylsilane

1-cyclopropyl-5,9-dimethyl-deca-4,8-dien-1-one
714230-48-5

1-cyclopropyl-5,9-dimethyl-deca-4,8-dien-1-one

(E)-2-Cyclopropyl-6,10-dimethyl-1-trimethylsilanyl-undeca-5,9-dien-2-ol
714230-49-6

(E)-2-Cyclopropyl-6,10-dimethyl-1-trimethylsilanyl-undeca-5,9-dien-2-ol

Conditions
ConditionsYield
Stage #1: Chloromethyltrimethylsilane With magnesium In diethyl ether
Stage #2: With cerium(III) chloride In tetrahydrofuran; diethyl ether at 0℃;
Stage #3: 1-cyclopropyl-5,9-dimethyl-deca-4,8-dien-1-one In tetrahydrofuran; diethyl ether at 0 - 20℃;
95%
lithium
7439-93-2

lithium

Chloromethyltrimethylsilane
2344-80-1

Chloromethyltrimethylsilane

trimethylsilylmethyllithium
1822-00-0

trimethylsilylmethyllithium

Conditions
ConditionsYield
In pentane95%
In pentane95%
In pentane at 40℃; for 16h; Argon gasification;80%
ethyl cinnamate
4192-77-2

ethyl cinnamate

Chloromethyltrimethylsilane
2344-80-1

Chloromethyltrimethylsilane

trimethyl[(3E)-2-methylene-4-phenylbut-3-en-1-yl]silane
80814-92-2, 117747-08-7

trimethyl[(3E)-2-methylene-4-phenylbut-3-en-1-yl]silane

Conditions
ConditionsYield
Stage #1: Chloromethyltrimethylsilane With magnesium In tetrahydrofuran at 20℃; for 3h;
Stage #2: ethyl cinnamate With cerium(III) chloride In tetrahydrofuran at -78 - 20℃;
Stage #3: With silica gel In dichloromethane at 20℃; for 3h; Further stages.;
95%
tributyltin chloride
1461-22-9

tributyltin chloride

magnesium
7439-95-4

magnesium

Chloromethyltrimethylsilane
2344-80-1

Chloromethyltrimethylsilane

(trimethylsilyl)(tributylstannyl)methane
77425-85-5

(trimethylsilyl)(tributylstannyl)methane

Conditions
ConditionsYield
With iodine; ammonium chloride In diethyl ether N2-atmosphere; addn. of Me3SiCH2Cl to Mg (activated with I2), refluxing(1 h), addn. of Bu3SnCl, refluxing (18 h); addn. of satd. aq. NH4Cl, extn. of aq. layer (ether), washing of org. layer (satd. aq. NaCl), drying (Na2SO4), evapn. of ether, distn. (vac.);95%
2-chloro-1-(2,4-dichlorophenyl)ethanone
51336-94-8

2-chloro-1-(2,4-dichlorophenyl)ethanone

(trimethylsilyl)methylmagnesium chloride
13170-43-9

(trimethylsilyl)methylmagnesium chloride

Chloromethyltrimethylsilane
2344-80-1

Chloromethyltrimethylsilane

1-(1-chloromethylethenyl)-2,4-difluorobenzene
156570-10-4

1-(1-chloromethylethenyl)-2,4-difluorobenzene

Conditions
ConditionsYield
Stage #1: (trimethylsilyl)methylmagnesium chloride; Chloromethyltrimethylsilane With magnesium In tert-butyl methyl ether at 55℃; for 4h;
Stage #2: 2-chloro-1-(2,4-dichlorophenyl)ethanone In tert-butyl methyl ether at -10 - 0℃;
Stage #3: With sulfuric acid In tert-butyl methyl ether at 25 - 50℃; for 3h;
95%
(S)-1-phenyl-ethylamine
2627-86-3

(S)-1-phenyl-ethylamine

Chloromethyltrimethylsilane
2344-80-1

Chloromethyltrimethylsilane

N-(S)-α-methylbenzyl-N-((trimethylsilyl)methyl)amine
135782-16-0

N-(S)-α-methylbenzyl-N-((trimethylsilyl)methyl)amine

Conditions
ConditionsYield
In neat (no solvent) at 200℃; for 3h; Sealed tube;94%
With triethylamine for 16h; Reflux; Inert atmosphere;76%
With potassium carbonate In acetonitrile for 4h; Heating;75%
(Z)-3-bromo-4-trimethylsilyl-3-buten-2-one
1257841-93-2

(Z)-3-bromo-4-trimethylsilyl-3-buten-2-one

Chloromethyltrimethylsilane
2344-80-1

Chloromethyltrimethylsilane

(Z)-2-bromo-3-methyl-1-trimethylsilyl-1,3-butadiene
1257841-99-8

(Z)-2-bromo-3-methyl-1-trimethylsilyl-1,3-butadiene

Conditions
ConditionsYield
Stage #1: Chloromethyltrimethylsilane With magnesium; ethylene dibromide In diethyl ether for 1h; Inert atmosphere; Reflux;
Stage #2: (Z)-3-bromo-4-trimethylsilyl-3-buten-2-one In diethyl ether at 0℃; Peterson olefination; Inert atmosphere;
Stage #3: With water; acetic acid at 50℃; for 6h; Peterson olefination; Inert atmosphere;
94%
[tris(trimethylsilyl)silyl]potassium

[tris(trimethylsilyl)silyl]potassium

Chloromethyltrimethylsilane
2344-80-1

Chloromethyltrimethylsilane

2-(trimethylsilyl)-2-[(trimethylsilyl)methyl]hexamethyltrisilane
1253730-05-0

2-(trimethylsilyl)-2-[(trimethylsilyl)methyl]hexamethyltrisilane

Conditions
ConditionsYield
In benzene at 0℃; for 2h;94%

Chloromethyltrimethylsilane Specification

The Chloromethyltrimethylsilane, with the CAS register number 2344-80-1, has other names as silane cmm3; trimethyl(chloromethyl)silane; trimethylsilylchloromethane; (trimethylsilyl)methyl chloride; (ch3)3sich2cl; (chloromethyl)trimethyl-silan; cc3285; chloromethyltrimethylsilane.

The characteristics of this chemical could be summarized as: (1)ACD/LogP: 2.52; (2)ACD/LogD (pH 5.5):2.52; (3)ACD/LogD (pH 7.4): 2.52; (4)ACD/BCF (pH 5.5): 48.33; (5)ACD/BCF (pH 7.4): 48.33 ; (6)ACD/KOC (pH 5.5): 558.7; (7)ACD/KOC (pH 7.4): 558.7; (8)#Freely Rotating Bonds: 1; (9)Index of Refraction: 1.397; (10)Molar Refractivity: 34.14 cm3; (11)Molar Volume: 141.6 cm3; (12)Polarizability: 13.53 ×10-24 cm3; (13)Surface Tension: 17.2 dyne/cm; (14)Density: 0.865 g/cm3; (15)Enthalpy of Vaporization: 32.17 kJ/mol; (16)Boiling Point: 96 °C at 760 mmHg; (17)Vapour Pressure: 50.6 mmHg at 25°C.

This is a kind of clear colorless liquid and is insoluble in water. Besides, it is sensitive to moisture, so it should be kept in the inflammables area and then keep under argon. And keep it in a cool, dry, well-ventilated area away from incompatible substances.

Being among the highly flammable chemicals, it may catch fire in contact with air, only needing brief contact with an ignition source, and it has a very low flash point or evolve highly flammable gases in contact with water. Besides, it is a kind of irritant chemical, it is irritating to eyes, respiratory system and skin, and it may cause burns and even the inflammation to the skin or other mucous membranes. What is more, it could destroy living tissue on contact, as it is corrosive.

So while dealing with this chemical, we should be very cautious and take the following instructions.   Wear suitable gloves and eye/face protection and suitable protective clothing; And then keep away from sources of ignition - No smoking and do not empty into drains at the same time. What's more, if in case of contact with eyes, rinse immediately with plenty of water and seek medical advice, and then take precautionary measures against static discharges. You could also get more safety information from WGK Germany  3.

Its product categories are including halides; pharmacetical; si (classes of silicon compounds); si-(c)4 compounds; silicon compounds (for synthesis); synthetic organic chemistry, while its preparation products are containing (trimethylsilyl)diazomethane, and n-(methoxymethyl)-n-(trimethylsilylmethyl)benzylamine.

Additionally, you could convert the following data information into the molecular structure:
SMILES:ClC[Si](C)(C)C
InChI:InChI=1/C4H11ClSi/c1-6(2,3)4-5/h4H2,1-3H3
InChIKey:OOCUOKHIVGWCTJ-UHFFFAOYAF

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