Product Name

  • Name

    Diethylaminoethanol

  • EINECS 202-845-2
  • CAS No. 100-37-8
  • Article Data52
  • CAS DataBase
  • Density 0.884 g/cm3
  • Solubility soluble in water
  • Melting Point -70 °C
  • Formula C6H15NO
  • Boiling Point 164.8 °C at 760 mmHg
  • Molecular Weight 117.191
  • Flash Point 48.9 °C
  • Transport Information UN 2686 8/PG 2
  • Appearance clear to pale yellow liquid
  • Safety 25-26-36/37/39-45
  • Risk Codes 10-20/21/22-34
  • Molecular Structure Molecular Structure of 100-37-8 (Diethylaminoethanol)
  • Hazard Symbols CorrosiveC
  • Synonyms 2-diethylaminoethanol;(2-Hydroxyethyl)diethylamine;(Diethylamino)ethanol;2-(Diethylamino)ethanol;2-(Diethylamino)ethyl alcohol;2-(N,N-Diethylamino)ethanol;2-Hydroxytriethylamine;A 22 (amine);DEAE;DEEA;Diethyl(b-hydroxyethyl)amine;Diethylethanolamine;MKS;N,N-Diethyl(2-hydroxyethyl)amine;N,N-Diethyl-2-aminoethanol;N,N-Diethylethanolamine;N,N-Diethylmonoethanolamine;N-(2-Hydroxyethyl)diethylamine;NSC 8759;Pennad 150;b-(Diethylamino)ethanol;
  • PSA 23.47000
  • LogP 0.32050

Synthetic route

oxirane
75-21-8

oxirane

diethylamine
109-89-7

diethylamine

2-(Diethylamino)ethanol
100-37-8

2-(Diethylamino)ethanol

Conditions
ConditionsYield
With 3-amino-2-propanol at 70℃; under 4500.45 Torr; for 3h; Pressure; Temperature;99.4%
With water
water at 85.84 - 94.84℃; under 1500.15 Torr; for 0.116667h; Heating / reflux;
at 76.84 - 112.84℃; under 1500.15 Torr; for 0.133333h; Heating / reflux;
diethylamine
109-89-7

diethylamine

2-bromoethanol
540-51-2

2-bromoethanol

2-(Diethylamino)ethanol
100-37-8

2-(Diethylamino)ethanol

Conditions
ConditionsYield
In ethanol at 60℃; for 6h; Inert atmosphere;96%
methanol
67-56-1

methanol

2-(diethylamino)ethyl crotonate
84115-05-9

2-(diethylamino)ethyl crotonate

A

crotonic acid methyl ester
623-43-8

crotonic acid methyl ester

B

2-(Diethylamino)ethanol
100-37-8

2-(Diethylamino)ethanol

Conditions
ConditionsYield
With toluene-4-sulfonic acid for 4h; Heating;A 90%
B 82%
...Expand
2-(diethylamino)ethyl crotonate
84115-05-9

2-(diethylamino)ethyl crotonate

A

crotonic acid methyl ester
623-43-8

crotonic acid methyl ester

B

2-(Diethylamino)ethanol
100-37-8

2-(Diethylamino)ethanol

Conditions
ConditionsYield
With methanol; toluene-4-sulfonic acid for 4h; Heating;A 90%
B 82%
2-methyl-4,5-dihydro-1,3-oxazole
1120-64-5

2-methyl-4,5-dihydro-1,3-oxazole

A

2-(Ethylamino)ethanol
110-73-6

2-(Ethylamino)ethanol

B

2-(Diethylamino)ethanol
100-37-8

2-(Diethylamino)ethanol

Conditions
ConditionsYield
With platinum on carbon; hydrogen at 25℃; under 7500.75 Torr; for 16h;A 60%
B 19%
2-amino-ethanol hydrochloride
2002-24-6

2-amino-ethanol hydrochloride

ethyl iodide
75-03-6

ethyl iodide

2-(Diethylamino)ethanol
100-37-8

2-(Diethylamino)ethanol

Conditions
ConditionsYield
Stage #1: 2-amino-ethanol hydrochloride With potassium carbonate; ethanolamine In acetonitrile Heating;
Stage #2: ethyl iodide for 6h; Heating;		7.8%
carbonic acid ethyl ester-(2-diethylamino-ethyl ester)
20570-43-8

carbonic acid ethyl ester-(2-diethylamino-ethyl ester)

A

2-(Diethylamino)ethanol
100-37-8

2-(Diethylamino)ethanol

B

Diethyl carbonate
105-58-8

Diethyl carbonate

diethyl sulfate
64-67-5

diethyl sulfate

ethanolamine
141-43-5

ethanolamine

2-(Diethylamino)ethanol
100-37-8

2-(Diethylamino)ethanol

Conditions
ConditionsYield
With sodium hydroxide at 40℃;
ethylene glycol
107-21-1

ethylene glycol

triethylamine
121-44-8

triethylamine

2-(Diethylamino)ethanol
100-37-8

2-(Diethylamino)ethanol

Conditions
ConditionsYield
at 300℃;
diethylamine
109-89-7

diethylamine

2-chloro-ethanol
107-07-3

2-chloro-ethanol

2-(Diethylamino)ethanol
100-37-8

2-(Diethylamino)ethanol

2-diethylamino-ethanol; protonated form
22451-37-2

2-diethylamino-ethanol; protonated form

2,6-Di-tert-butyl-4-(3,5-di-tert-butyl-4-oxo-cyclohexa-2,5-dienylidenemethyl)-phenol anion
22719-43-3

2,6-Di-tert-butyl-4-(3,5-di-tert-butyl-4-oxo-cyclohexa-2,5-dienylidenemethyl)-phenol anion

A

2,6-di-tert-butyl-4-(3,5-di-tert-butyl-4-hydroxy-benzylidene)-cyclohexa-2,5-dienone
4359-97-1

2,6-di-tert-butyl-4-(3,5-di-tert-butyl-4-hydroxy-benzylidene)-cyclohexa-2,5-dienone

B

2-(Diethylamino)ethanol
100-37-8

2-(Diethylamino)ethanol

Conditions
ConditionsYield
In acetonitrile at 25℃; under 682.6 Torr; Equilibrium constant; var. temp., var. pressures; ΔH0, ΔS0;
...Expand
Diethyl-(2-hydroxy-ethyl)-methoxymethyl-ammonium; bromide
76441-70-8

Diethyl-(2-hydroxy-ethyl)-methoxymethyl-ammonium; bromide

A

2-Diethylamino-1-methoxymethoxy-ethan
76441-74-2

2-Diethylamino-1-methoxymethoxy-ethan

B

2-(Diethylamino)ethanol
100-37-8

2-(Diethylamino)ethanol

Conditions
ConditionsYield
With 2,3-dimercapto-succinic acid at 50℃;
ethylene glycol
107-21-1

ethylene glycol

diethylamine
109-89-7

diethylamine

A

N,N,N',N'-Tetraethylethylenediamine
150-77-6

N,N,N',N'-Tetraethylethylenediamine

B

2-(Diethylamino)ethanol
100-37-8

2-(Diethylamino)ethanol

Conditions
ConditionsYield
With tris(triphenylphosphine)ruthenium(II) chloride at 120℃; for 2h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
With ruthenium trichloride at 120℃; for 2.5h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
...Expand
2-(diethylamino)ethyl chloride
100-35-6

2-(diethylamino)ethyl chloride

2-(Diethylamino)ethanol
100-37-8

2-(Diethylamino)ethanol

Conditions
ConditionsYield
With methanol at 25℃; Kinetics; Thermodynamic data; pH 12; ΔH(excit.), ΔS(excit.);
C14H26N2O(2+)*HO(1-)*I(1-)

C14H26N2O(2+)*HO(1-)*I(1-)

A

4-ethenyl-1-methylpyridinium iodide
21351-43-9

4-ethenyl-1-methylpyridinium iodide

B

2-(Diethylamino)ethanol
100-37-8

2-(Diethylamino)ethanol

Conditions
ConditionsYield
In water at 25℃; Rate constant; ionic strength 0.1 mol dm-3;
phenyl-carbamic acid-(2-diethylamino-ethyl ester); hydrochloride
3739-10-4

phenyl-carbamic acid-(2-diethylamino-ethyl ester); hydrochloride

A

carbon dioxide
124-38-9

carbon dioxide

B

aniline
62-53-3

aniline

C

2-(Diethylamino)ethanol
100-37-8

2-(Diethylamino)ethanol

Conditions
ConditionsYield
With sodium hydroxide In ethanol; water at 40℃; Rate constant; Thermodynamic data; var. temp., EA;
...Expand
Procaine
59-46-1

Procaine

A

4-amino-benzoic acid
150-13-0

4-amino-benzoic acid

B

2-(Diethylamino)ethanol
100-37-8

2-(Diethylamino)ethanol

Conditions
ConditionsYield
With Tris-HCl buffer; human liver carboxylesterase pI 4.5 at 37℃; pH=7.4; Enzyme kinetics; Hydrolysis;
With sodium hydroxide Kinetics;
diethylaminoacetic acid ester

diethylaminoacetic acid ester

2-(Diethylamino)ethanol
100-37-8

2-(Diethylamino)ethanol

Conditions
ConditionsYield
With ethanol; sodium
diethylamine
109-89-7

diethylamine

ethylene dioxide

ethylene dioxide

2-(Diethylamino)ethanol
100-37-8

2-(Diethylamino)ethanol

Conditions
ConditionsYield
at 150℃;
With methanol at 45 - 60℃;
at 150℃;
ethylene glycol
107-21-1

ethylene glycol

triethylamine
121-44-8

triethylamine

Fuller's earth

Fuller's earth

2-(Diethylamino)ethanol
100-37-8

2-(Diethylamino)ethanol

Conditions
ConditionsYield
at 300℃; unter Druck;
...Expand
2-(diethylamino)ethyl chloride
100-35-6

2-(diethylamino)ethyl chloride

sodium arsenite

sodium arsenite

2-(Diethylamino)ethanol
100-37-8

2-(Diethylamino)ethanol

Conditions
ConditionsYield
Produkt 2: ein ungesaettigtes Amin;
oxirane
75-21-8

oxirane

methanol
67-56-1

methanol

diethylamine
109-89-7

diethylamine

A

2-(Diethylamino)ethanol
100-37-8

2-(Diethylamino)ethanol

B

mono-2-diethylamino-ethyl ether of ethylene glycol

mono-2-diethylamino-ethyl ether of ethylene glycol

C

mono-2-diethylamino-ethyl ether of diethylene glycol

mono-2-diethylamino-ethyl ether of diethylene glycol

D

mono-2-diethylamino-ethyl ether of triethylene glycol

mono-2-diethylamino-ethyl ether of triethylene glycol

Conditions
ConditionsYield
at 45 - 60℃; Pr.5: Mono-2-diaethylamino-aethylaether von Tetraaethylenglykol;
...Expand
diethyl ether
60-29-7

diethyl ether

N,N-diacetyl-glycine ethyl ester
98426-78-9

N,N-diacetyl-glycine ethyl ester

LiAlH4

LiAlH4

2-(Diethylamino)ethanol
100-37-8

2-(Diethylamino)ethanol

Conditions
ConditionsYield
at 5℃; bei der Reduktion;
...Expand
carbonic acid-(2-diethylamino-ethyl ester)-menthyl ester

carbonic acid-(2-diethylamino-ethyl ester)-menthyl ester

A

(-)-menthol
2216-51-5

(-)-menthol

B

2-(Diethylamino)ethanol
100-37-8

2-(Diethylamino)ethanol

C

carbonic acid bis-<β-diethylamino-ethyl ester>

carbonic acid bis-<β-diethylamino-ethyl ester>

D

di-l-menthyl carbonate

di-l-menthyl carbonate

Conditions
ConditionsYield
zerfaellt beim Erhitzen;
...Expand
procaine hydrochloride
51-05-8

procaine hydrochloride

2-(Diethylamino)ethanol
100-37-8

2-(Diethylamino)ethanol

Conditions
ConditionsYield
With water; sodium dodecyl-sulfate; sodium hydroxide at 40℃; Kinetics; Reagent/catalyst; Temperature;
triethylamine
121-44-8

triethylamine

2-(Diethylamino)ethanol
100-37-8

2-(Diethylamino)ethanol

Conditions
ConditionsYield
With potassium tetrachloroplatinate(II); copper(II) choride dihydrate; sulfuric acid; water at 150℃; for 24h; Sealed tube;
2-methyl-4-oxo-3,1-benzoxazine
525-76-8

2-methyl-4-oxo-3,1-benzoxazine

2-(Diethylamino)ethanol
100-37-8

2-(Diethylamino)ethanol

β-(diethylamino)ethyl o-acetamidobenzoate
82679-12-7

β-(diethylamino)ethyl o-acetamidobenzoate

Conditions
ConditionsYield
at 100℃; for 1h;100%
2-phenylethynyl-quinoline-3-carbaldehyde
868765-12-2

2-phenylethynyl-quinoline-3-carbaldehyde

2-(Diethylamino)ethanol
100-37-8

2-(Diethylamino)ethanol

C24H26N2O2
1262748-30-0

C24H26N2O2

Conditions
ConditionsYield
With triphenylphosphine at 20℃; for 0.5h;100%
C14H11NO2
947697-83-8

C14H11NO2

2-(Diethylamino)ethanol
100-37-8

2-(Diethylamino)ethanol

C20H26N2O3
1262748-23-1

C20H26N2O3

Conditions
ConditionsYield
With silver(l) oxide at 20℃; for 1.5h; Inert atmosphere; regioselective reaction;100%
With triphenylphosphine at 20℃; for 2h;99%
C12H10BrN3O3
1313913-27-7

C12H10BrN3O3

2-(Diethylamino)ethanol
100-37-8

2-(Diethylamino)ethanol

C18H23BrN4O3
1313913-34-6

C18H23BrN4O3

Conditions
ConditionsYield
With di-tert-butyl-diazodicarboxylate In dichloromethane at 20℃; for 0.5h; Mitsunobu reaction;100%
dimethyl sulfate
77-78-1

dimethyl sulfate

2-(Diethylamino)ethanol
100-37-8

2-(Diethylamino)ethanol

N,N-diethyl-N-2-hydroxyethyl-N-methylammonium methylsulfate

N,N-diethyl-N-2-hydroxyethyl-N-methylammonium methylsulfate

Conditions
ConditionsYield
In acetonitrile at -20 - 40℃; for 60.5h;100%
In acetonitrile at 20 - 40℃; for 60.5h;100%
2-(Diethylamino)ethanol
100-37-8

2-(Diethylamino)ethanol

methyl iodide
74-88-4

methyl iodide

N,N-diethyl-N-methyl-N-(2-methoxyethyl)ammonium iodide

N,N-diethyl-N-methyl-N-(2-methoxyethyl)ammonium iodide

Conditions
ConditionsYield
Stage #1: 2-(Diethylamino)ethanol With sodium hydride In tetrahydrofuran at 25 - 40℃; for 0.5h;
Stage #2: methyl iodide at 40℃; for 7h; Product distribution / selectivity;		99.1%
Stage #1: 2-(Diethylamino)ethanol With sodium hydride In tetrahydrofuran at 25 - 40℃; for 0.5h;
Stage #2: methyl iodide In tetrahydrofuran at 40℃; for 7h;		99.1%
2-(3,3-dimethylbut-1-ynyl)quinoline-3-carbaldehyde
947698-03-5

2-(3,3-dimethylbut-1-ynyl)quinoline-3-carbaldehyde

2-(Diethylamino)ethanol
100-37-8

2-(Diethylamino)ethanol

C22H30N2O2
1262748-21-9

C22H30N2O2

Conditions
ConditionsYield
With silver(l) oxide at 20℃; for 3h; Inert atmosphere; regioselective reaction;99%
2-(Diethylamino)ethanol
100-37-8

2-(Diethylamino)ethanol

2-(N-methylmethylsulfonamido)ethyl methanesulfonate

2-(N-methylmethylsulfonamido)ethyl methanesulfonate

N,N-diethyl-2-hydroxy-N-(2-(methylsulfonamido)ethyl)ethaneammonium methanesulfonate
1392481-58-1

N,N-diethyl-2-hydroxy-N-(2-(methylsulfonamido)ethyl)ethaneammonium methanesulfonate

Conditions
ConditionsYield
In ethanol at 100℃; for 24h;99%
2,6-dichloropyrazine
4774-14-5

2,6-dichloropyrazine

2-(Diethylamino)ethanol
100-37-8

2-(Diethylamino)ethanol

2-(6-chloropyrazin-2-yloxy)-N,N-diethylethanamine
1247497-41-1

2-(6-chloropyrazin-2-yloxy)-N,N-diethylethanamine

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran at 20℃;99%
Stage #1: 2-(Diethylamino)ethanol With sodium hydride In tetrahydrofuran at 20℃; for 0.166667h;
Stage #2: 2,6-dichloropyrazine In tetrahydrofuran at 50℃; for 0.166667h; Microwave irradiation;		95%
2-Amino-4,6-dichloropyrimidine
56-05-3

2-Amino-4,6-dichloropyrimidine

2-(Diethylamino)ethanol
100-37-8

2-(Diethylamino)ethanol

4-chloro-6-(2-(diethylamino)ethoxy)pyrimidin-2-amine
1507138-87-5

4-chloro-6-(2-(diethylamino)ethoxy)pyrimidin-2-amine

Conditions
ConditionsYield
With sodium hydride for 0.166667h; Microwave irradiation;99%
C23H34O6Si

C23H34O6Si

2-(Diethylamino)ethanol
100-37-8

2-(Diethylamino)ethanol

C29H47NO6Si

C29H47NO6Si

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 7h;99%
2-(Diethylamino)ethanol
100-37-8

2-(Diethylamino)ethanol

2-chloro-N,N-diethylethylamine hydrochloride
869-24-9

2-chloro-N,N-diethylethylamine hydrochloride

Conditions
ConditionsYield
Stage #1: 2-(Diethylamino)ethanol With thionyl chloride In dichloromethane at -10 - 35℃; for 2.5h;
Stage #2: With hydrogenchloride		98.08%
With thionyl chloride; chloroform at -5℃;
With thionyl chloride In chloroform
2-(Diethylamino)ethanol
100-37-8

2-(Diethylamino)ethanol

4-nitro-benzoic acid
62-23-7

4-nitro-benzoic acid

2-(diethylamino)ethyl 4-nitrobenzoate
13456-39-8

2-(diethylamino)ethyl 4-nitrobenzoate

Conditions
ConditionsYield
With formic acid In 5,5-dimethyl-1,3-cyclohexadiene for 24h; Reflux;98%
With Candida antarctica lipase B immobilised in a macroporous DVB crosslinked polymer (Novozym 435) In cyclohexane at 80℃; for 48h; Enzymatic reaction;
(1R,3S,9aS)-3-((R)-1-Nitroso-piperidin-2-yl)-octahydro-quinolizine-1-carboxylic acid methyl ester

(1R,3S,9aS)-3-((R)-1-Nitroso-piperidin-2-yl)-octahydro-quinolizine-1-carboxylic acid methyl ester

2-(Diethylamino)ethanol
100-37-8

2-(Diethylamino)ethanol

(1R,3S,9aS)-3-((R)-1-Nitroso-piperidin-2-yl)-octahydro-quinolizine-1-carboxylic acid 2-diethylamino-ethyl ester

(1R,3S,9aS)-3-((R)-1-Nitroso-piperidin-2-yl)-octahydro-quinolizine-1-carboxylic acid 2-diethylamino-ethyl ester

Conditions
ConditionsYield
With sodium97.2%
Butyl chloroethynyl sulfide
56424-15-8

Butyl chloroethynyl sulfide

2-(Diethylamino)ethanol
100-37-8

2-(Diethylamino)ethanol

2-(Butylthiomethylene)-3,3-diethyl-1,3-oxazolidinium chloride
91418-10-9

2-(Butylthiomethylene)-3,3-diethyl-1,3-oxazolidinium chloride

Conditions
ConditionsYield
In diethyl ether97%
In diethyl ether at 20℃; for 3h;97%
(iso-butylthio)chloroacetylene
66566-81-2

(iso-butylthio)chloroacetylene

2-(Diethylamino)ethanol
100-37-8

2-(Diethylamino)ethanol

3,3-Diethyl-2-[1-isobutylsulfanyl-meth-(E)-ylidene]-oxazolidin-3-ium; chloride
97427-23-1

3,3-Diethyl-2-[1-isobutylsulfanyl-meth-(E)-ylidene]-oxazolidin-3-ium; chloride

Conditions
ConditionsYield
In diethyl ether at 20℃; for 3h;97%
ethyl 4-nitrobenzoate
99-77-4

ethyl 4-nitrobenzoate

2-(Diethylamino)ethanol
100-37-8

2-(Diethylamino)ethanol

Procaine
59-46-1

Procaine

Conditions
ConditionsYield
With hydrogen; palladium-containing anion exchanger AV-17-8 In ethanol at 45℃; under 760 Torr;97%
methyl 3-pyridinecarboxylate
93-60-7

methyl 3-pyridinecarboxylate

2-(Diethylamino)ethanol
100-37-8

2-(Diethylamino)ethanol

nicametate
3099-52-3

nicametate

Conditions
ConditionsYield
With N,N'-biscyclohexyl-imidazol-2-ylidene; 4 A molecular sieve In tetrahydrofuran at 20℃; for 2h;97%
With tetraethylammonium bicarbonate at 60℃; for 2h;84%
With platinum; 1-butyl-3-methylimidazolium Tetrafluoroborate at 20 - 60℃; for 2h; Inert atmosphere; Electrochemical reaction; Green chemistry;62%
homoalylic alcohol
627-27-0

homoalylic alcohol

1,1'-carbonyldiimidazole
530-62-1

1,1'-carbonyldiimidazole

2-(Diethylamino)ethanol
100-37-8

2-(Diethylamino)ethanol

C11H21NO3

C11H21NO3

Conditions
ConditionsYield
Stage #1: homoalylic alcohol; 1,1'-carbonyldiimidazole In dichloromethane at 0 - 20℃; for 3h; Inert atmosphere;
Stage #2: 2-(Diethylamino)ethanol In dichloromethane at 20℃; Inert atmosphere;		97%
...Expand
5-[6-(3-hydroxy-phenyl)-pyridazin-3-yl]-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid tert-butyl ester
848592-40-5

5-[6-(3-hydroxy-phenyl)-pyridazin-3-yl]-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid tert-butyl ester

2-(Diethylamino)ethanol
100-37-8

2-(Diethylamino)ethanol

5-[6-[3-(2-diethylamino-ethoxy)-phenyl]-pyridazin-3-yl]-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid tert-butyl ester

5-[6-[3-(2-diethylamino-ethoxy)-phenyl]-pyridazin-3-yl]-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid tert-butyl ester

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In dichloromethane at 0 - 20℃; for 2h;96%
With di-isopropyl azodicarboxylate; polymer-bound triphenylphosphine In dichloromethane at 0 - 20℃; for 73h;54%
carbon monoxide
201230-82-2

carbon monoxide

1-bromo-4-butoxybenzene
39969-57-8

1-bromo-4-butoxybenzene

2-(Diethylamino)ethanol
100-37-8

2-(Diethylamino)ethanol

butoxycaine
3772-43-8

butoxycaine

Conditions
ConditionsYield
With dmap; sodium carbonate; bis(dibenzylideneacetone)-palladium(0); catacxium A In toluene at 100℃; for 18h; Glovebox; Sealed tube; Inert atmosphere;96%
With dmap; sodium carbonate; bis(dibenzylideneacetone)-palladium(0); catacxium A In toluene at 80℃; Inert atmosphere; Sealed chamber;87.4 mg
...Expand
2-(Diethylamino)ethanol
100-37-8

2-(Diethylamino)ethanol

aspirin
50-78-2

aspirin

diethylaminoethylacetylsalicylate acetylsalicylate

diethylaminoethylacetylsalicylate acetylsalicylate

Conditions
ConditionsYield
Stage #1: aspirin With dicyclohexyl-carbodiimide In chloroform at 5 - 20℃; for 2h;
Stage #2: 2-(Diethylamino)ethanol at 20℃; for 3h;		96%
2-(Diethylamino)ethanol
100-37-8

2-(Diethylamino)ethanol

aspirin
50-78-2

aspirin

diethylaminoethyl acetylsalicylate acetylsalicylic acid salt

diethylaminoethyl acetylsalicylate acetylsalicylic acid salt

Conditions
ConditionsYield
Stage #1: aspirin With dicyclohexyl-carbodiimide In chloroform at 5 - 20℃; for 2h;
Stage #2: 2-(Diethylamino)ethanol In chloroform at 20℃; for 3h;		96%
Stage #1: aspirin With dicyclohexyl-carbodiimide In chloroform at 5 - 20℃; for 2h;
Stage #2: 2-(Diethylamino)ethanol In chloroform at 20℃; for 3h;		96%
diethylamine
109-89-7

diethylamine

2-(Diethylamino)ethanol
100-37-8

2-(Diethylamino)ethanol

acetylene
74-86-2

acetylene

1,5-bis-(N,N-diethylamino)diethylether
3030-43-1

1,5-bis-(N,N-diethylamino)diethylether

Conditions
ConditionsYield
With sodium ethanolate In dibutyl ether at 50℃; for 7h;95.3%
...Expand
acetic anhydride
108-24-7

acetic anhydride

2-(Diethylamino)ethanol
100-37-8

2-(Diethylamino)ethanol

2-(diethylamino)ethyl acetate
10369-82-1

2-(diethylamino)ethyl acetate

Conditions
ConditionsYield
With nickel dichloride at 20℃; for 0.5h; Neat (no solvent);95%
With benzene
bromethyl methyl ether
13057-17-5

bromethyl methyl ether

2-(Diethylamino)ethanol
100-37-8

2-(Diethylamino)ethanol

Diethyl-(2-hydroxy-ethyl)-methoxymethyl-ammonium; bromide
76441-70-8

Diethyl-(2-hydroxy-ethyl)-methoxymethyl-ammonium; bromide

Conditions
ConditionsYield
In diethyl ether temperature not higher than 5 deg C;95%
4,7-dichloroquinoline
86-98-6

4,7-dichloroquinoline

2-(Diethylamino)ethanol
100-37-8

2-(Diethylamino)ethanol

O-(7-chloro-4-quinolyl)-2-(N,N-diethylamino)ethanol

O-(7-chloro-4-quinolyl)-2-(N,N-diethylamino)ethanol

Conditions
ConditionsYield
Stage #1: 2-(Diethylamino)ethanol With sodium hydride In N,N-dimethyl-formamide for 0.5h;
Stage #2: 4,7-dichloroquinoline In N,N-dimethyl-formamide for 0.5h;		95%
2-ethoxy-4,4,6-trimethyl-1,3,2-dioxaborinane
52386-21-7

2-ethoxy-4,4,6-trimethyl-1,3,2-dioxaborinane

2-(Diethylamino)ethanol
100-37-8

2-(Diethylamino)ethanol

2-diethylaminoethoxy-4,4,6-trimethyl-1,3,2-dioxaborinane
13561-17-6

2-diethylaminoethoxy-4,4,6-trimethyl-1,3,2-dioxaborinane

Conditions
ConditionsYield
In benzene byproducts: ethanol; amine added to B compd., benzene added, shaken and refluxed for 2 h, moisture excluded; EtOH-benzene distd. azeotropically, solvent evapd. in vac. at room temp., distd.; elem. anal.;95%

Diethylaminoethanol Consensus Reports

Reported in EPA TSCA Inventory.

Diethylaminoethanol Standards and Recommendations

OSHA PEL: TWA 10 ppm (skin)
ACGIH TLV: TWA 10 ppm (skin)
DFG MAK: 5 ppm (24 mg/m3)
DOT Classification:  3; Label: Flammable Liquid

Diethylaminoethanol Analytical Methods

For occupational chemical analysis use NIOSH: Aminoethanol Compounds, 2007.

Diethylaminoethanol Specification

The CAS registry number of 2-Diethylaminoethanol is 100-37-8. Its EINECS registry number is 202-845-2. In addition, the molecular formula is C6H15NO. The systematic name is 2-(diethylamino)ethanol. What's more, it is used as pharmaceutical intermediates, softeners, emulsifiers and curing agents.

Physical properties about this chemical are: (1)ACD/LogP: 0.74; (2)ACD/BCF (pH 5.5): 1; (3)ACD/BCF (pH 7.4): 1; (4)ACD/KOC (pH 5.5): 1; (5)ACD/KOC (pH 7.4): 1; (6)#H bond acceptors: 2; (7)#H bond donors: 1; (8)#Freely Rotating Bonds: 5; (9)Polar Surface Area: 23.47 Å2; (10)Index of Refraction: 1.443; (11)Molar Refractivity: 35.1 cm3; (12)Molar Volume: 132.3 cm3; (13)Polarizability: 13.91 ×10-24cm3; (14)Surface Tension: 31.4 dyne/cm; (15)Density: 0.885 g/cm3; (16)Flash Point: 48.9 °C; (17)Enthalpy of Vaporization: 46.73 kJ/mol; (18)Boiling Point: 164.8 °C at 760 mmHg; (19)Vapour Pressure: 0.651 mmHg at 25°C.

Preparation of 2-Diethylaminoethanol: it can be prepared by diethylamine and epoxyethane at the certain temperature. The equation is as follows:

2-Diethylaminoethanol can be prepared by diethylamine and epoxyethane at the certain temperature

Uses of 2-Diethylaminoethanol: it can react with isocyanatomethyl-benzene to get N-Benzyl-carbaminsaeure-(2-diethylamino-ethylester). This reaction will need reagent triethylamine and solvent diethyl ether. The yield is about 74% at reaction temperature of 20-30 °C.

2-Diethylaminoethanol can react with isocyanatomethyl-benzene to get N-Benzyl-carbaminsaeure-(2-diethylamino-ethylester).

When you are using this chemical, please be cautious about it as the following:
This chemical is flammable and can cause burns. And it is harmful by inhalation, in contact with skin and if swallowed. During using it, wear suitable protective clothing, gloves and eye/face protection and avoid contact with eyes. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. And in case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.).

You can still convert the following datas into molecular structure:
(1)SMILES: CCN(CC)CCO
(2)Std.InChI: InChI=1S/C6H15NO/c1-3-7(4-2)5-6-8/h8H,3-6H2,1-2H3
(3)Std.InChIKey: BFSVOASYOCHEOV-UHFFFAOYSA-N

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 skin 1mL/kg (1mL/kg)   Journal of Industrial Hygiene and Toxicology. Vol. 26, Pg. 269, 1944.
human TCLo inhalation 200ppm (200ppm) GASTROINTESTINAL: NAUSEA OR VOMITING "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 216, 1969.
mammal (species unspecified) LDLo unreported 1300mg/kg (1300mg/kg)   "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 216, 1969.
mouse LC50 inhalation 5000mg/m3 (5000mg/m3) BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS

SENSE ORGANS AND SPECIAL SENSES: CONJUNCTIVE IRRITATION: EYE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 14(11), Pg. 52, 1970.
mouse LD50 intramuscular 416mg/kg (416mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 9, Pg. 31, 1959.
mouse LD50 intraperitoneal 192mg/kg (192mg/kg) BEHAVIORAL: ATAXIA Journal of Pharmacology and Experimental Therapeutics. Vol. 94, Pg. 249, 1948.
mouse LD50 intravenous 188mg/kg (188mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES		 Arzneimittel-Forschung. Drug Research. Vol. 9, Pg. 31, 1959.
mouse LD50 subcutaneous 650mg/kg (650mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES		 Arzneimittel-Forschung. Drug Research. Vol. 9, Pg. 31, 1959.
rabbit LD50 skin 1260uL/kg (1.26mL/kg)   Union Carbide Data Sheet. Vol. 6/11/1963,
rat LCLo inhalation 4500mg/m3/4H (4500mg/m3) BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS

SENSE ORGANS AND SPECIAL SENSES: CONJUNCTIVE IRRITATION: EYE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 14(11), Pg. 52, 1970.
rat LD50 intraperitoneal 1220mg/kg (1220mg/kg)   Toxicology and Applied Pharmacology. Vol. 12, Pg. 486, 1968.
rat LD50 oral 1300mg/kg (1300mg/kg)   Journal of Industrial Hygiene and Toxicology. Vol. 26, Pg. 269, 1944.

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