Ethanolamine supplier | CasNO.141-43-5

Name
Ethanolamine
EINECS 205-483-3
CAS No. 141-43-5
Article Data257
CAS DataBase
Density 0.973 g/cm³
Solubility miscible with water
Melting Point 10-11 °C(lit.)
Formula C₂H₇NO
Boiling Point 170.9 °C at 760 mmHg
Molecular Weight 61.0837
Flash Point 93.3 °C
Transport Information UN 2924 3/PG 3
Appearance clear liquid
Safety 26-36/37/39-45
Risk Codes 20/21/22-34-39/23/24/25-23/24/25-10
Molecular Structure
Hazard Symbols C,T
Synonyms EPA Pesticide Chemical Code 011601;Ethanol, 2-amino;2-aminoethanol;Thiofaco M-50;Ethylolamine;colamine;beta-Aminoethyl alcohol;2-Ethanolamine;2-Aminoethyl alcohol;beta-Hydroxyethylamine;beta-Aminoethanol;1-Amino-2-hydroxyethane;Aminoethanol;Envision Conditioner PDD 9020;2-Hydroxyethylamine;Ethanol, 2-amino- (8CI,9CI);2-Hydroxyethanamine;Ethanol,2-amino-;Olamine;beta-Aminoethyl alcohol beta-Ethanolamine;2-Amino-1-ethanol;Chemical material series;MEA 141-43-5 Monoethanolamine;H-Gly-ol;
PSA 46.25000
LogP -0.36230

Synthetic route

: trityl-(3-trityloxy-propyl)-amine

: 141-43-5
ethanolamine

Conditions

Conditions	Yield
With sodium hydrogen sulfate; silica gel In methanol; dichloromethane at 20℃; for 3.5h;	95%

: 100-46-9
benzylamine

: 88891-55-8
5-(2-hydroxyethyl)hexahydro-1,3,5-dithiazine

A: 2547-66-2
1,3,5-Tribenzyl-1,3,5-triazacyclohexane

B: 141-43-5
ethanolamine

Conditions

Conditions	Yield
at 20℃; for 24h;	A 95% B n/a

...Expand

: 625-48-9
2-nitro-1-ethanol

A: 141-43-5
ethanolamine

B: 30635-68-8
2-hydroxyethylhydroxylamine

Conditions

Conditions	Yield
With hydrogen In para-xylene; isopropyl alcohol at 25℃; under 760.051 Torr; for 3h;	A 5% B 95%

: 56-40-6
glycine

: 141-43-5
ethanolamine

Conditions

Conditions	Yield
With sulfuric acid; hydrogen In water at 79.84℃; under 60006 Torr;	92.3%
With zinc borohydride In tetrahydrofuran for 7h; Heating;	70%
With sodium tetrahydroborate; iodine In tetrahydrofuran

: 693-06-1
(2-hydroxyethyl)-formamide

: 141-43-5
ethanolamine

Conditions

Conditions	Yield
With caesium carbonate In methanol at 60℃; for 8h;	92%

: 24070-16-4
N-tritylethanolamine

: 141-43-5
ethanolamine

Conditions

Conditions	Yield
With sodium hydrogen sulfate; silica gel In methanol; dichloromethane at 20℃; for 3.5h;	90%

: 104-63-2
N-Benzylethanolamine

: 141-43-5
ethanolamine

Conditions

Conditions	Yield
With ammonium formate; palladium on activated charcoal In methanol for 0.166667h; Heating;	86%
With 9,10-Dicyanoanthracene In water; acetonitrile Irradiation;	80%
With di-isopropyl azodicarboxylate In tetrahydrofuran at 20℃; for 336h;

: 23147-58-2, 110822-84-9, 110822-85-0
glycolaldehyde dimer

: 141-43-5
ethanolamine

Conditions

Conditions	Yield
With ammonium hydroxide; Ni6AlO(z); hydrogen at 80℃; under 3750.38 Torr; for 3h; Autoclave;	85%
With ammonia; hydrogen; cobalt/manganese/sodium/phosphorous reduced catalyst In water at 100℃; under 75007.5 Torr; for 8h; Product distribution / selectivity; Autoclave;

: 26646-35-5
2-(3-nitrophenoxy)ethanamine

A: C8H9N2O3(1-)

B: 554-84-7
meta-nitrophenol

C: 55131-09-4
N-(2-hydroxyethyl)-3-nitroaniline

D: 141-43-5
ethanolamine

Conditions

Conditions	Yield
With deuteriated sodium hydroxide In water-d2 at 20℃; for 0.833333h; Smiles rearrangement; UV-irradiation;	A 15% B n/a C 73% D n/a

...Expand

: 616-34-2
methoxycarbonylmethylamine

: 141-43-5
ethanolamine

Conditions

Conditions	Yield
With sodium tetrahydroborate In diethylene glycol dimethyl ether at 76 - 78℃; for 3h;	70%
With lithium aluminium tetrahydride In tetrahydrofuran for 5h;

: 598-42-5
glycolamide

: 141-43-5
ethanolamine

Conditions

Conditions	Yield
With hydrogen; iridium In cyclohexane; glycerol at 180℃; under 15001.5 Torr; for 3.08h; Reagent/catalyst; Temperature; Solvent; Pressure; Autoclave;	61%

: 4746-64-9
2-aminoacetyl chloride

: 141-43-5
ethanolamine

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In tetrahydrofuran for 2h; Heating;	55%

: 75-21-8
oxirane

: 7664-41-7
ammonia

A: 102-71-6
triethanolamine

B: 141-43-5
ethanolamine

C: 111-42-2
2,2'-iminobis[ethanol]

Conditions

Conditions	Yield
water at 48.84 - 76.84℃; under 12751.3 Torr; for 0.25h;	A 7.7% B 52.1% C 40.2%

...Expand

: 107-21-1
ethylene glycol

A: 110-85-0
piperazine

B: 141-43-5
ethanolamine

C: 111-41-1
2-(2-Aminoethylamino)ethanol

D: 107-15-3
ethylenediamine

E: 111-40-0
1,5-diamino-3-azapentane

F: 111-42-2
2,2'-iminobis[ethanol]

Conditions

Conditions	Yield
Stage #1: ethylene glycol With ammonia; hydrogen at 150℃; under 150015 Torr; Stage #2: copper oxide; graphite; molybdenum oxide; nickel oxide; zirconium dioxide; mixture of at 170℃; under 150015 Torr;	A 6.8% B 29% C 5.7% D 49.5% E 3.9% F 1.7%
With ammonia; hydrogen at 170 - 180℃; under 150015 Torr; Conversion of starting material;
With ammonia; water; hydrogen at 180℃; under 150015 Torr; Conversion of starting material;
With ammonia; hydrogen at 150 - 170℃; under 150015 Torr; Conversion of starting material;
With ammonia; hydrogen at 200℃; under 150015 Torr; Conversion of starting material;

...Expand

: 110-73-6
2-(Ethylamino)ethanol

A: 50-00-0
formaldehyd

B: 75-04-7
ethylamine

C: 141-43-5
ethanolamine

D: 75-07-0
acetaldehyde

Conditions

Conditions	Yield
With water at 25℃; anodic oxidation, pH 10, carbonate buffer; Further byproducts given;	A 14% B 43% C 45% D 44%

...Expand

: 110-73-6
2-(Ethylamino)ethanol

A: 50-00-0
formaldehyd

B: 75-04-7
ethylamine

C: 141-43-5
ethanolamine

D: 75-07-0
acetaldehyde

E: 141-46-8
Glycolaldehyde

Conditions

Conditions	Yield
With water at 25℃; Product distribution; Mechanism; anodic oxidation, carbonate buffer, pH 10; effect of substituents investigated with different types of β-alkanolamines;	A 14% B 43% C 45% D 44% E n/a

...Expand

: 5680-79-5
glycine ethyl ester hydrochloride

: 141-43-5
ethanolamine

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In tetrahydrofuran for 2h; Heating;	44%

: 7336-29-0
2-aminoethyl vinyl ether

A: 16250-70-7
2-methyl-2,3,4,5-tetrahydroisoxazole

B: 93555-19-2
N-Ethylideneethanolamine Vinyl Ether

C: 141-43-5
ethanolamine

Conditions

Conditions	Yield
With palladium dichloride In benzene Heating;	A 21% B 33% C n/a
mercury(II) diacetate In hexane at 60℃; for 4h;	A 20% B 28.3 g C 26.1 g

...Expand

: 591-51-5
phenyllithium

: 113556-34-6
N-(1,2,5-trimethylpiperidinylidene-4-)-β-hydroxyethylamine

A: 7516-33-8
1,2,5-trimethyl-4-piperidone

B: 141-43-5
ethanolamine

C: 113556-41-5
1,2,5-trimethyl-4-phenyl-4-N-(β-hydroxyethyl)aminopiperidine

Conditions

Conditions	Yield
In diethyl ether	A n/a B n/a C 11%

...Expand

: 100-52-7
benzaldehyde

: 141-43-5
ethanolamine

: 104-63-2
N-Benzylethanolamine

Conditions

Conditions	Yield
Stage #1: benzaldehyde; ethanolamine In methanol at 20℃; for 0.25h; Stage #2: With methanol; sodium tetrahydroborate at 0 - 20℃;	100%
With copper chromium spinel oxide; hydrogen; barium(II) oxide at 130℃; under 37503 Torr; for 1h;	97.8%
Stage #1: benzaldehyde; ethanolamine With magnesium sulfate In methanol at 20℃; for 18h; Stage #2: With sodium tetrahydroborate In methanol at 0 - 20℃; for 1h;	95%

: 50-00-0
formaldehyd

: 141-43-5
ethanolamine

: 4719-04-4
1,3,5-tris(2-hydroxyethyl)-1,3,5-triazacyclohexane

Conditions

Conditions	Yield
In methanol at 20℃; for 16h;	100%
In methanol for 48h;	86%
With water
In ethanol Cyclization;
at 50 - 80℃; for 1h;	92 g

: 50-00-0
formaldehyd

: 141-43-5
ethanolamine

: 88788-08-3
N-(hydroxyethyl)aminomethanesulfonic acid

Conditions

Conditions	Yield
Stage #1: formaldehyd; ethanolamine In water at 10℃; for 24h; Stage #2: With sulfur dioxide In water at 20℃; pH=<= 1.0;	100%
With water und anschliessende Saettigung mit SO2;

: 14352-61-5
methyl cyclohexylacetate

: 141-43-5
ethanolamine

: 2-cyclohexyl-N-(2-hydroxyethyl)acetamide

Conditions

Conditions	Yield
With 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine In acetonitrile at 20℃; for 15h; Schlenk technique; Inert atmosphere;	100%
at 100 - 120℃;

: 141-43-5
ethanolamine

: 501-53-1
benzyl chloroformate

: 77987-49-6
benzyl 2-hydroxyethylcarbamate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 1h;	100%
In benzene for 0.5h; Ambient temperature;	95%
With triethylamine In dichloromethane at 20℃; for 6h; Large scale;	95.3%

: 141-43-5
ethanolamine

: 108-10-1
4-methyl-2-pentanone

: 32781-30-9
(2-aminoethanol)methyl isobutyl ketimine

Conditions

Conditions	Yield
at 76 - 99℃; under 252.025 Torr; for 2h; Dean-Stark;	100%
In cyclohexane at 90.7 - 105.9℃; for 2h; Dean-Stark; Reflux;	99%
In cyclohexane at 90.7 - 105.9℃; for 2h; Dean-Stark;	99%

: 141-43-5
ethanolamine

: 98-59-9
p-toluenesulfonyl chloride

: 14316-14-4
N-(2-hydroxy-ethyl)-4-methyl-benzenesulfonamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 18h; Inert atmosphere;	100%
With triethylamine In dichloromethane at 0 - 20℃; for 24h;	99%
With pyridine at 5 - 20℃;	96%

: 141-43-5
ethanolamine

: 109-94-4
formic acid ethyl ester

: 693-06-1
(2-hydroxyethyl)-formamide

Conditions

Conditions	Yield
Stage #1: ethanolamine With sodium ethanolate at 20℃; for 0.5h; Stage #2: formic acid ethyl ester In ethanol for 1h; Heating; Further stages.;	100%
at 10 - 20℃; for 12h;	100%
	99%

: 383-63-1
ethyl trifluoroacetate,

: 141-43-5
ethanolamine

: 6974-29-4
N-(2-hydroxyethyl)-2,2,2-trifluoroacetamide

Conditions

Conditions	Yield
In acetonitrile	100%
at 20℃; for 2h;	100%
With triethylamine In methanol; water	95%

: 141-43-5
ethanolamine

: 762-04-9
phosphonic acid diethyl ester

: 14662-78-3
(2-hydroxy-ethyl)-phosphoramidic acid diethyl ester

Conditions

Conditions	Yield
With potassium carbonate; potassium hydrogencarbonate; tetrabutylammomium bromide In tetrachloromethane; dichloromethane at 15 - 20℃; for 2h;	100%
With tetrachloromethane; triethylamine In tetrahydrofuran at 0 - 20℃; Atherton-Tood reaction; Inert atmosphere;	100%
With triethylamine In tetrachloromethane; benzene

: 141-43-5
ethanolamine

: 93-91-4
1-phenylbutan-1,3-dione

: 65271-13-8
(Z)-3-(2-hydroxyethylamino)-1-phenylbut-2-en-1-one

Conditions

Conditions	Yield
at 130℃; for 0.0833333h; microwave irradiation;	100%
With potassium dihydrogenphosphate at 50℃; for 0.5h; neat (no solvent);	96%
With β‐cyclodextrin In water at 20℃; for 0.5h; chemospecific reaction;	88%

: 16801-19-7
2-[2-(vinyloxy)ethoxymethyl]oxirane

: 141-43-5
ethanolamine

: 1-{(2-Hydroxy-ethyl)-[2-hydroxy-3-(2-vinyloxy-ethoxy)-propyl]-amino}-3-(2-vinyloxy-ethoxy)-propan-2-ol

Conditions

Conditions	Yield
at 60℃; for 4h;	100%

: 1118-02-1
trimethylsilyl isocyanate

: 141-43-5
ethanolamine

: 75226-85-6
<2-(trimethylsilyloxy)ethyl>urea

Conditions

Conditions	Yield
at 20 - 80℃; for 2h;	100%

: 87459-26-5
2,2,4-trichlorobutanal

: 141-43-5
ethanolamine

: 128538-93-2
7,7-Dichloro-hexahydro-pyrrolo[2,1-b]oxazole

Conditions

Conditions	Yield
	100%

: 24424-99-5
di-tert-butyl dicarbonate

: 141-43-5
ethanolamine

: 26690-80-2
2-(N-tert-butoxycarbonylamino)ethanol

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 5h;	100%
aminosulfonic acid at 25 - 28℃; for 0.0833333h;	100%
With sodium hydroxide In 1,4-dioxane; water at 0℃; for 2h;	100%

: 605-65-2
5-(dimethylamino)naphth-1-ylsulfonyl chloride

: 141-43-5
ethanolamine

: 5282-89-3
5-dimethylamino-N-(2-hydroxyethyl)naphthalene-1-sulfonamide

Conditions

Conditions	Yield
With pyridine for 17h; sulfonylation;	100%
With triethylamine In dichloromethane	98%
In water at 80℃;	96%

: 100238-69-5
dimethylisocyanatosilane

: 141-43-5
ethanolamine

: (2-Dimethylsilanyloxy-ethyl)-urea

Conditions

Conditions	Yield
In tetrahydrofuran at -5 - 19℃; for 2h;	100%

: 7468-67-9
o-formylbenzonitrile

: 141-43-5
ethanolamine

: 93679-81-3
3-(2-Hydroxy-ethylamino)-2,3-dihydro-isoindol-1-one

Conditions

Conditions	Yield
at 40℃; for 1h;	100%

: 59565-09-2
2-(vinyloxy)ethyl isothiocyanate

: 141-43-5
ethanolamine

: 111290-30-3
1-(2-Hydroxy-ethyl)-3-(2-vinyloxy-ethyl)-thiourea

Conditions

Conditions	Yield
	100%

: C106H123N37O59P9(9-)

: 141-43-5
ethanolamine

: C99H118N38O59P9(9-)

Conditions

Conditions	Yield
In water at 65℃; for 14h;	100%

: 141-43-5
ethanolamine

: 61489-23-4
2,3:5,6-di-O-cyclohexylidene-D-manno-furanose

: N-(2,3;5,6-di-O-cyclohexylidene-D-mannofuranosyl)ethanolamine

Conditions

Conditions	Yield
With acetic acid In benzene for 1h; Heating;	100%

: 141-43-5
ethanolamine

: 3-carboethoxy-5-bis(trifluoromethyl)-2-pyrazoline

: 3-monoethanolamido-5-bis(trifluoromethyl)-2-pyrazoline

Conditions

Conditions	Yield
In diethyl ether; water at 20℃; for 12h;	100%

: 141-43-5
ethanolamine

: 125215-31-8
4-(ethoxycarbonylamino)-thiophene-3-carboxaldehyde

: 125215-44-3
(4-{[(E)-2-Hydroxy-ethylimino]-methyl}-thiophen-3-yl)-carbamic acid ethyl ester

Conditions

Conditions	Yield
In ethanol for 0.333333h; Heating;	100%

: 141-43-5
ethanolamine

: 125215-33-0
(2-Ethyl-4-formyl-thiophen-3-yl)-carbamic acid ethyl ester

: 125215-46-5
(2-Ethyl-4-{[(E)-2-hydroxy-ethylimino]-methyl}-thiophen-3-yl)-carbamic acid ethyl ester

Conditions

Conditions	Yield
In ethanol for 0.333333h; Heating;	100%

: 141-43-5
ethanolamine

: 125215-34-1
(4-Formyl-2,5-dimethyl-thiophen-3-yl)-carbamic acid ethyl ester

: 125215-47-6
(4-{[(E)-2-Hydroxy-ethylimino]-methyl}-2,5-dimethyl-thiophen-3-yl)-carbamic acid ethyl ester

Conditions

Conditions	Yield
In ethanol for 0.333333h; Heating;	100%

: 141-43-5
ethanolamine

: 100890-40-2
1-Methyl-6-methylsulfanyl-2,4-dioxo-3-phenyl-1,2,3,4-tetrahydro-pyrimidine-5-carbonitrile

: 115351-90-1
6-(2-Hydroxy-ethylamino)-1-methyl-2,4-dioxo-3-phenyl-1,2,3,4-tetrahydro-pyrimidine-5-carbonitrile

Conditions

Conditions	Yield
In acetonitrile for 0.0833333h; Ambient temperature;	100%

: 141-43-5
ethanolamine

: 96286-28-1
5-Methoxy-4-phenyl-5,6-dihydro-4H-[1,3,4]thiadiazine

: 2-(4-Phenyl-5,6-dihydro-4H-[1,3,4]thiadiazin-5-ylamino)-ethanol

Conditions

Conditions	Yield
Ambient temperature;	100%

: 141-43-5
ethanolamine

: 75386-17-3
tetramethyl-2,2,3,3-dimethylamino-5-ethoxy-7 carboethoxy-9 trioxa-1,4,6 diaza-8,9 phospha(V)-5 spiro(4,4)noneme-7,8

: tetramethyl-2,2,3,3 dimethylamino-5 aza-6 trioxa-1,4,9 phospha(V)-5 spiro(4,4) nonane

Conditions

Conditions	Yield
In diethyl ether for 1h; Ambient temperature;	100%

: 141-43-5
ethanolamine

: 393-52-2
2-Fluorobenzoyl chloride

: 111904-31-5
2-fluoro-N-(2-hydroxyethyl)benzamide

Conditions

Conditions	Yield
With sodium hydroxide In dichloromethane; water for 1h; Ambient temperature;	100%
With triethylamine In dichloromethane at 25℃; for 2h;	95%
With potassium carbonate In methanol at 0 - 20℃; for 15h; Inert atmosphere;

: 141-43-5
ethanolamine

: 139649-70-0
2-fluoro-2,2-dinitroethylchloroformate, pentafluorosulfanylimine

: 139649-73-3
N-(2-hydroxyethyl)-2-fluoro-2,2-dinitroethyl carbamate, pentafluorosulfanylimine

Conditions

Conditions	Yield
In dichloromethane at 0℃; for 1.5h;	100%

Ethanolamine Chemical Properties

The molecular structure of Ethanolamine (CAS No. 141-43-5):

IUPAC Name: 2-Aminoethanol
Molecular Formula: C₂H₇NO
Molecular Weight: 61.10g/mol
EINECS: 205-483-3
Melting Point: 10.3 ºC
Freely Rotating Bonds: 3
Polar Surface Area: 46.25 Å²
Index of Refraction: 1.435
Molar Refractivity: 16.38 cm³
Molar Volume: 62.7 cm³
Polarizability: 6.49 ×10^-24cm³
Surface Tension: 39.7 dyne/cm
Density: 0.973 g/cm³
Flash Point: 93.3 °C
Melting point: 10-11 °C(lit.)
Enthalpy of Vaporization: 47.43 kJ/mol
Boiling Point: 170.9 °C at 760 mmHg
Vapour Pressure: 0.458 mmHg at 25°C
EINECS: 205-483-3
Product Categories: Pharmaceutical Intermediates; Thanolamine Series; omega-Aminoalkanols; omega-Functional Alkanols, Carboxylic Acids, Amines & Halides

Ethanolamine Production

Ethanolamine (CAS NO.141-43-5) is produced by reacting ethylene oxide with aqueous ammonia; the reaction also produces diethanolamine and triethanolamine.

Ethanolamine Toxicity Data With Reference

1.	ratLD50:1500mg/kg	Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 23(9), Pg. 55, 1979.
2.	ratLD50:1720mg/kg	Toxicology and Applied Pharmacology. Vol. 42, Pg. 417, 1977.
3.	rabbitLD50:1mL/kg	Union Carbide Data Sheet. Vol. 1/13/1972,
4.	mouseLD50:700mg/kg	Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 4, Pg. 81, 1962.

Ethanolamine Safety Profile

Hazard Codes: Toxic T Corrosive C
Risk Statements: 20/21/22-34-39/23/24/25-23/24/25-10
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed.
R34: Causes burns.
R23/24/25: Toxic by inhalation, in contact with skin and if swallowed.
R10: Flammable.
Safety Statements: 26-36/37/39-45
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 2924 3/PG 3
WGK Germany: 1
RTECS: KJ5775000
F: 8-10-23
HazardClass: 8
PackingGroup: III

Ethanolamine Specification

Ethanolamine , with CAS number of 141-43-5, can be called 1-Amino-2-hydroxyethane ; 2-Amino-1-ethanol ; 2-Aminoaethanol ; EPA Pesticide Chemical Code 011601 ; Glycinol (monoethanolamine) ; Monoaethanolamin ; Monoethanolamine . It can be used in organic synthesis.The extinguishing agent of Ethanolamine (CAS NO.141-43-5) are dry powder, foam, sand, carbon dioxide, water mist.

Product Name

Ethanolamine

Synthetic route

Ethanolamine Chemical Properties

Ethanolamine Production

Ethanolamine Toxicity Data With Reference

Ethanolamine Safety Profile

Ethanolamine Specification

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