Glycerol formal supplier | CasNO.4740-78-7

Name
Glycerol formal
EINECS 225-248-9
CAS No. 4740-78-7
Article Data40
CAS DataBase
Density 1.217 g/cm³
Solubility
Melting Point
Formula C₄H₈O₃
Boiling Point 193.8 °C at 760 mmHg
Molecular Weight 104.106
Flash Point 78.9 °C
Transport Information
Appearance Clear liquid
Safety 23-24/25
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms m-Dioxan-5-ol(7CI);1,3-Formalglycerol;5-Hydroxy-1,3-dioxane;5-Hydroxy-m-dioxane;1,3-Dioxan-5-ol;
PSA 38.69000
LogP -0.64840

Synthetic route

: 4740-78-7
glycerol formal

: 50-00-0
formaldehyd

: 56-81-5
glycerol

A: 5464-28-8
1,3-dioxolane-4-methanol

B: 4740-78-7
glycerol formal

Conditions

Conditions	Yield
With dihydrogen peroxide; nitric acid; cetyltrimethylammonim bromide; ferric nitrate In water at 80℃; for 5h; Reagent/catalyst; Temperature;	A n/a B 95.6%
With hydrogenchloride	A 44% B 56%
With hydrogenchloride In water at 40℃; for 24h; Yields of byproduct given;

...Expand

: 109-87-5
Dimethoxymethane

: 56-81-5
glycerol

A: 5464-28-8
1,3-dioxolane-4-methanol

B: 4740-78-7
glycerol formal

Conditions

Conditions	Yield
	A 6% B 94%
With toluene-4-sulfonic acid; lithium bromide In ethyl acetate at 20℃; for 16h; Yield given. Yields of byproduct given;
With toluene-4-sulfonic acid; lithium bromide at 20℃; for 16h; Product distribution; Mechanism; other temperature, other substrates, reactants;

...Expand

: 56-81-5
glycerol

A: 5464-28-8
1,3-dioxolane-4-methanol

B: 4740-78-7
glycerol formal

C: 79-14-1
glycolic Acid

D: 623-50-7
ethyl 2-hydroxyacetate

E: 627-82-7
diglycerol

F: 556-52-5
oxiranyl-methanol

G: 116-09-6
hydroxy-2-propanone

H: 107-02-8
acrolein

Conditions

Conditions	Yield
With pretreated aluminium vanadium phosphate In water at 280℃; under 760.051 Torr; Catalytic behavior; Activation energy; Reagent/catalyst; Temperature;	A n/a B n/a C n/a D n/a E n/a F n/a G n/a H 62%

...Expand

: 56-81-5
glycerol

(HCHO)n: (HCHO)n

A: 5464-28-8
1,3-dioxolane-4-methanol

B: 4740-78-7
glycerol formal

Conditions

Conditions	Yield
With toluene-4-sulfonic acid	A 60% B 40%

...Expand

: 49784-60-3
1,3-dioxan-5-ol benzoate

: 4740-78-7
glycerol formal

Conditions

Conditions	Yield
With sodium In methanol; chloroform at 20℃; for 48h;	48%
With potassium hydroxide
With methanol; chloroform; sodium methylate

: 50-00-0
formaldehyd

: 56-81-5
glycerol

: 4740-78-7
glycerol formal

Conditions

Conditions	Yield
With hydrogen cation	36%
With hydrogenchloride at 0℃;
at 160 - 200℃; im Druckrohr und Destillation des Reaktionsprodukts unter vermindertem Druck;
With hydrogenchloride
With Amberlyst-15 at 100℃; for 1h; Temperature; Reagent/catalyst;

: 56-81-5
glycerol

polyoxymethylene: polyoxymethylene

A: 5464-28-8
1,3-dioxolane-4-methanol

B: 4740-78-7
glycerol formal

Conditions

Conditions	Yield
With bismuth(lll) trifluoromethanesulfonate In 1,4-dioxane at 40℃; for 0.5h; Sealed tube; Sonication;	A 15% B 28%

...Expand

: 50-00-0
formaldehyd

: 124-63-0
methanesulfonyl chloride

: 56-81-5
glycerol

A: 4740-78-7
glycerol formal

B: 1,3-dioxolan-4-ylmethyl methanesulfonate

Conditions

Conditions	Yield
With triethylamine Multistep reaction;

...Expand

: 50-00-0
formaldehyd

: 98-59-9
p-toluenesulfonyl chloride

: 56-81-5
glycerol

A: 4740-78-7
glycerol formal

B: 85608-69-1
(1,3-dioxolan-4-yl)methyl 4-methylbenzenesulfonate

Conditions

Conditions	Yield
With triethylamine Yield given. Multistep reaction. Yields of byproduct given;

...Expand

: 7647-01-0
hydrogenchloride

: 56-81-5
glycerol

polyoxymethylene: polyoxymethylene

A: 5464-28-8
1,3-dioxolane-4-methanol

B: 4740-78-7
glycerol formal

Conditions

Conditions	Yield
at 130℃;
at 100℃;

...Expand

: 7664-93-9
sulfuric acid

: 56-81-5
glycerol

polyoxymethylene: polyoxymethylene

A: 5464-28-8
1,3-dioxolane-4-methanol

B: 4740-78-7
glycerol formal

Conditions

Conditions	Yield
at 130℃;
at 100℃;

...Expand

: 7647-01-0
hydrogenchloride

: 50-00-0
formaldehyd

: 56-81-5
glycerol

A: 5464-28-8
1,3-dioxolane-4-methanol

B: 4740-78-7
glycerol formal

...Expand

: 110-88-3
1,3,5-Trioxan

: 56-81-5
glycerol

A: 5464-28-8
1,3-dioxolane-4-methanol

B: 4740-78-7
glycerol formal

Conditions

Conditions	Yield
With sodium tetrachloroaurate dihydrate In 1,4-dioxane at 100℃; for 16h; Kinetics; Reagent/catalyst; Temperature; Time; Solvent;

...Expand

: 1404077-71-9
C9H16O4

: 2,2-Dimethyl-propionic acid [1,3]dioxolan-4-ylmethyl ester

A: 5464-28-8
1,3-dioxolane-4-methanol

B: 4740-78-7
glycerol formal

Conditions

Conditions	Yield
With sodium hydroxide In ethanol at 20℃; for 18h; Inert atmosphere;

...Expand

: 56-81-5
glycerol

A: 4740-78-7
glycerol formal

B: 2806-84-0
3-methoxy-1-propanal

C: 75-07-0
acetaldehyde

D: 116-09-6
hydroxy-2-propanone

E: 107-02-8
acrolein

Conditions

Conditions	Yield
With H-ZSM5 In water at 340℃; under 760.051 Torr; for 6h; Reagent/catalyst; Inert atmosphere;

...Expand

: 50-00-0
formaldehyd

: 56-81-5
glycerol

A: 5464-28-8
1,3-dioxolane-4-methanol

B: 4740-78-7
glycerol formal

C: C9H16O6

D: C8H14O6

E: C7H12O6

Conditions

Conditions	Yield
With cesium 12-tungstophosphate at 70℃; Reagent/catalyst;

...Expand

: 100-52-7
benzaldehyde

: 56-81-5
glycerol

: 4740-78-7
glycerol formal

Conditions

Conditions	Yield
With zinc-modified strong acid polystyrene cation exchange at 150℃; for 5h;

: 56-81-5
glycerol

A: 5464-28-8
1,3-dioxolane-4-methanol

B: 4740-78-7
glycerol formal

C: 64-18-6
formic acid

Conditions

Conditions	Yield
With dihydrogen peroxide In water at 200℃; for 10h; Catalytic behavior; Reagent/catalyst; Flow reactor; Autoclave; Green chemistry; chemoselective reaction;

...Expand

: 56-81-5
glycerol

A: 5464-28-8
1,3-dioxolane-4-methanol

B: 4740-78-7
glycerol formal

C: 64-18-6
formic acid

D: 64-19-7
acetic acid

E: 116-09-6
hydroxy-2-propanone

Conditions

Conditions	Yield
With dihydrogen peroxide In water at 200℃; for 13h; Flow reactor; Autoclave; Green chemistry; chemoselective reaction;

...Expand

: 56-81-5
glycerol

A: 5464-28-8
1,3-dioxolane-4-methanol

B: 4740-78-7
glycerol formal

C: 64-18-6
formic acid

D: 64-19-7
acetic acid

Conditions

Conditions	Yield
With dihydrogen peroxide In water at 200℃; for 21h; Catalytic behavior; Time; Flow reactor; Autoclave; Green chemistry; chemoselective reaction;

...Expand

: 56-81-5
glycerol

A: 5464-28-8
1,3-dioxolane-4-methanol

B: 4740-78-7
glycerol formal

C: 116-09-6
hydroxy-2-propanone

Conditions

Conditions	Yield
With alumina; dihydrogen peroxide In water at 200℃; for 4h; Catalytic behavior; Time; Flow reactor; Autoclave; chemoselective reaction;

...Expand

: 4740-78-7
glycerol formal

: 57-10-3
1-hexadecylcarboxylic acid

: 163550-89-8
hexadecanoic acid [1,3]dioxan-5-yl ester

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide Esterification;	93%

: 4740-78-7
glycerol formal

: 112-80-1
cis-Octadecenoic acid

: 277749-20-9
(Z)-Octadec-9-enoic acid [1,3]dioxan-5-yl ester

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide Esterification;	92%

: 4740-78-7
glycerol formal

: 106-89-8
epichlorohydrin

: 1333247-50-9
1,3-bis[(1,3-dioxan-5-yl)oxy]propan-2-ol

Conditions

Conditions	Yield
With tetrabutylammomium bromide; water; potassium hydroxide at 20 - 60℃; for 48h; Inert atmosphere; neat (no solvent);	90%

: 4740-78-7
glycerol formal

: 112-38-9
10-undecenoic acid

: 277749-21-0
undec-10-enoic acid [1,3]dioxan-5-yl ester

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide Esterification;	89%

: 4740-78-7
glycerol formal

: 334-48-5
1-decanoic acid

: 15180-87-7
decanoic acid [1,3]dioxan-5-yl ester

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide Esterification;	82%

: 4740-78-7
glycerol formal

: 112-85-6
n-docosanoic acid

: 277749-19-6
docosanoic acid [1,3]dioxan-5-yl ester

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide Esterification;	80%

: 4740-78-7
glycerol formal

: 109-52-4
valeric acid

: 15180-73-1
pentanoic acid [1,3]dioxan-5-yl ester

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide Esterification;	80%

: 4740-78-7
glycerol formal

: E-6-amino-9-<1-methyl-2-(tetrahydropyran-2-yloxy)ethenyl>-9H-purine

: 9-[2-Bromo-1-([1,3]dioxan-5-yloxy)-1-methyl-2-(tetrahydro-pyran-2-yloxy)-ethyl]-9H-purin-6-ylamine

Conditions

Conditions	Yield
With N-Bromosuccinimide Ambient temperature;	60%

: 4740-78-7
glycerol formal

: 3282-30-2
pivaloyl chloride

: 2,2-Dimethyl-propionic acid [1,3]dioxolan-4-ylmethyl ester

Conditions

Conditions	Yield
With 1,3-dioxolane-4-methanol; pyridine In dichloromethane Inert atmosphere;	44%

: 4740-78-7
glycerol formal

: 2-(2H-tetrazol-5-yl)-N-[4-(trifluoromethyl)phenyl]aniline

2-(2-(1,3-dioxan-5-yl)-2H-tetrazol-5-yl)-N-(4-(trifluoromethyl)phenyl)aniline: 2-(2-(1,3-dioxan-5-yl)-2H-tetrazol-5-yl)-N-(4-(trifluoromethyl)phenyl)aniline

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 20℃; for 16h; Inert atmosphere;	42.6%

: 4740-78-7
glycerol formal

: 159383-03-6
6-amino-9-(isopropenyl)-9H-purine

: 9-[2-Bromo-1-([1,3]dioxan-5-yloxy)-1-methyl-ethyl]-9H-purin-6-ylamine

Conditions

Conditions	Yield
With N-Bromosuccinimide Ambient temperature;	30%

: 4740-78-7
glycerol formal

: 87683-81-6
1,3-dioxan-5-one

Conditions

Conditions	Yield
With Collins reagent	12%
With pyridinium chlorochromate In dichloromethane

: 4740-78-7
glycerol formal

: 22128-62-7
carbonochloridic acid, chloromethyl ester

: 214543-57-4
chloromethyl (1,3-dioxan-5-yl) carbonate

Conditions

Conditions	Yield
With pyridine In diethyl ether at 0℃; for 20h;	5%

: 4740-78-7
glycerol formal

: 98-88-4
benzoyl chloride

: 49784-60-3
1,3-dioxan-5-ol benzoate

Conditions

Conditions	Yield
With quinoline
With pyridine

: 4740-78-7
glycerol formal

: 103-71-9
phenyl isocyanate

: 92368-06-4
phenyl-carbamic acid-[1,3]dioxan-5-yl ester

: 4740-78-7
glycerol formal

: 77-78-1
dimethyl sulfate

: 99586-36-4
5-methoxy-1,3-dioxane

Conditions

Conditions	Yield
With potassium hydroxide

: 4740-78-7
glycerol formal

: 51953-54-9
5-chloro-1,3-dioxane

Conditions

Conditions	Yield
With pyridine; thionyl chloride

: 4740-78-7
glycerol formal

: 75-44-5
phosgene

: C5H7ClO4

: 5464-28-8
1,3-dioxolane-4-methanol

: 4740-78-7
glycerol formal

: 6362-89-6
2-chloro-1,3,2-dioxaphosphinane

A: 219133-84-3
2-(1,3-dioxan-5-yloxy)-1,3,2-dioxaphosphorinane

B: 219133-79-6
2-[1,2-(methylenedioxy)propyloxy]-1,3,2-dioxaphosphorinane

Conditions

Conditions	Yield
With triethylamine In diethyl ether at -10 - 20℃; for 1h; phosphorylation; Title compound not separated from byproducts;

...Expand

Glycerol formal Chemical Properties

Molecule structure of Glycerol formal (CAS NO.4740-78-7):

IUPAC Name: 1,3-Dioxan-5-ol
Molecular Formula: C₄H₈O₃
Molecular Weight: 104.10452 g/mol
Density: 1.217 g/cm³
Boiling Point: 193.8 °C at 760 mmHg
Flash Point: 78.9 °C
Index of Refraction: 1.455
Molar Refractivity: 23.24 cm³
Molar Volume: 85.5 cm³
Surface Tension: 40.7 dyne/cm
Enthalpy of Vaporization: 50.04 kJ/mol
Vapour Pressure: 0.12 mmHg at 25 °C
XLogP3-AA: -0.8
H-Bond Donor: 1
H-Bond Acceptor: 3
Exact Mass: 104.047344
MonoIsotopic Mass: 104.047344
Topological Polar Surface Area: 38.7
Heavy Atom Count: 7
Canonical SMILES: C1C(COCO1)O
InChI: InChI=1S/C4H8O3/c5-4-1-6-3-7-2-4/h4-5H,1-3H2
InChIKey: VCKSNYNNVSOWEE-UHFFFAOYSA-N
EINECS: 225-248-9
Product Categories: Pharmaceutical Intermediates

Glycerol formal Uses

Glycerol formal (CAS NO.4740-78-7) is mainly used as a solvent of pesticide and drug injection.

Glycerol formal Safety Profile

Safety Statements: 23-24/25
S23:Do not breathe vapour.
S24/25:Avoid contact with skin and eyes.
WGK Germany: 3
F: 3

Glycerol formal Specification

Glycerol formal (CAS NO.4740-78-7) is also named as 1,3-Dioxan-5-ol ; 1,3-Formalglycerol ; 5-m-Dioxanol ; 5-Hydroxy-m-dioxane ; m-Dioxan-5-ol(7CI) . Glycerol formal (CAS NO.4740-78-7) is clear liquid.

Product Name

Glycerol formal

Synthetic route

Glycerol formal Chemical Properties

Glycerol formal Uses

Glycerol formal Safety Profile

Glycerol formal Specification

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