Malonic acid supplier | CasNO.141-82-2

Name
Malonic acid
EINECS 205-503-0
CAS No. 141-82-2
Article Data303
CAS DataBase
Density 1.546 g/cm³
Solubility water: 1400 g/L (20 °C)
Melting Point 132-135 °C (dec.)(lit.)
Formula C₃H₄O₄
Boiling Point 386.808 °C at 760 mmHg
Molecular Weight 104.062
Flash Point 201.905 °C
Transport Information
Appearance Crystalline
Safety 26-36/39-37/39-36
Risk Codes 20/22-41-36/37/38-22
Molecular Structure
Hazard Symbols Xn,Xi
Synonyms Dicarboxymethane;Carboxyacetic acid;Malonic acid （Electronical grade）;Malonicacid;Malonic acid(medicine grade);Malonic Acid (P516);USAF EK-695;Propanedioic acid Malonic Acid;Propanedioic acid (9CI);Methanedicarboxylic acid;1,3-Propanedioic acid;Malonic acid;propanedioec acid;
PSA 74.60000
LogP -0.45430

Synthetic route

: 926-61-4
3-oxopropanoic acid

: 141-82-2
malonic acid

Conditions

Conditions	Yield
With C4H11FeMo6NO24(3-)*3C16H36N(1+); water; oxygen; sodium carbonate at 50℃; under 760.051 Torr; for 8h; Green chemistry;	99%
With 4H3N4H(1+)CuMo6O18(OH)6(4-); water; oxygen; sodium carbonate at 50℃; under 760.051 Torr; for 12h;	93%

: 503-66-2
3-hydroxypropionic acid

: 141-82-2
malonic acid

Conditions

Conditions	Yield
With sodium hydroxide In water	97%
With sodium hydroxide elektrochemische Oxydation, am besten an einer Nickelanode;

: 108-59-8
malonic acid dimethyl ester

: 141-82-2
malonic acid

Conditions

Conditions	Yield
With water at 70 - 80℃;	97%
With water; sodium hydroxide In methanol at 80℃; for 1h;

: 105-53-3
diethyl malonate

: 141-82-2
malonic acid

Conditions

Conditions	Yield
With acetic acid In water at 70 - 80℃; Reagent/catalyst;	95%
With hydrogen ethyl malonate; sulfuric acid at 70℃; under 175 Torr; Abdestillieren des entstehenden Aethanols;
With malonic acid; sulfuric acid at 70℃; under 175 Torr; Abdestillieren des entstehenden Aethanols;

: 3815-86-9
malonic acid dihydrazide

: 75-15-0
carbon disulfide

A: 141-82-2
malonic acid

B: 1072-71-5
2,5-Dimercapto-1,3,4-thiadiazole

Conditions

Conditions	Yield
Stage #1: malonic acid dihydrazide; carbon disulfide With potassium hydroxide In ethanol for 3h; Rearrangement; cyclization; Heating; Stage #2: With hydrogenchloride In ethanol Hydrolysis; ring cleavage;	A n/a B 90%

...Expand

: 108-13-4
malonodiamide

: 141-82-2
malonic acid

Conditions

Conditions	Yield
With niobium(V) oxide; water In neat (no solvent) for 30h; Reflux; Inert atmosphere;	82%

: 108-59-8
malonic acid dimethyl ester

A: 141-82-2
malonic acid

B: 16695-14-0
Malonic acid monomethyl ester

Conditions

Conditions	Yield
Stage #1: malonic acid dimethyl ester With potassium hydroxide; water In acetonitrile at 0℃; for 1h; Stage #2: With hydrogenchloride; water In acetonitrile Product distribution / selectivity;	A n/a B 81%
Stage #1: malonic acid dimethyl ester With water; potassium hydroxide at 0℃; for 1.5h; Stage #2: Acidic aq. solution;	A 9.8% B 76%

: 105-53-3
diethyl malonate

A: 141-82-2
malonic acid

B: 1071-46-1
hydrogen ethyl malonate

Conditions

Conditions	Yield
Stage #1: diethyl malonate With water; potassium hydroxide In tetrahydrofuran at 0℃; for 0.5h; Stage #2: In tetrahydrofuran; water Acidic conditions;	A 8.3% B 76.9%
Stage #1: diethyl malonate With water; potassium hydroxide at 0℃; for 6h; Stage #2: Acidic aq. solution;	A 36.6% B 35.6%

: 60-33-3
linoleic acid

A: 141-82-2
malonic acid

B: 142-62-1
hexanoic acid

Conditions

Conditions	Yield
With phosphotungstic acid; dihydrogen peroxide; cetylpyridinium bromide In water at 85℃; for 5h; Concentration; Green chemistry;	A 49.8% B 60.7%

: 2033-24-1
cycl-isopropylidene malonate

: 141-82-2
malonic acid

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate In dichloromethane at 20℃; for 18h;	60%

: 617-48-1
malic acid

A: 328-42-7
Oxalacetic acid

B: 141-82-2
malonic acid

C: 144-62-7
oxalic acid

Conditions

Conditions	Yield
With iron disulphate; dihydrogen peroxide at 2℃;	A 16% B 12% C 58%

...Expand

: 2919-23-5
cyclobutanol

A: 1191-95-3
cyclobutanone

B: 141-82-2
malonic acid

Conditions

Conditions	Yield
With potassium hydroxide; potassium permanganate at 0℃; for 0.05h;	A 8.5% B 57%
With potassium hydroxide; potassium permanganate In water at 0℃; for 0.05h; Product distribution; Mechanism;	A 8.5% B 57%

: 7270-63-5
5-diazo-2,2-dimethyl-1,3-dioxane-4,6-dion

A: 68695-08-9
6,6-dimethyl-4,8-dioxo-5,7-dioxa-1,2-diazaspiro<2.5>oct-1-ene

B: 2033-24-1
cycl-isopropylidene malonate

C: 80-69-3
tartronic acid

D: 141-82-2
malonic acid

E: 62609-78-3
2,2-dimethyl-5-oxo-1,3-dioxolane-4-carboxylic acid

Conditions

Conditions	Yield
In tetrahydrofuran; water for 3.5h; Product distribution; Irradiation;	A 14% B 5% C 12% D 6% E 56%

...Expand

: 7597-56-0
ethyl malonamate

A: 60-35-5
acetamide

B: 141-82-2
malonic acid

C: 1071-46-1
hydrogen ethyl malonate

D: 64-19-7
acetic acid

Conditions

Conditions	Yield
With phthalic anhydride at 240 - 250℃; under 3040 Torr; for 1h; Hydrolysis;	A n/a B n/a C 53% D n/a

...Expand

: 615-94-1
2,5-dihydroxy-1,4-benzoquinone

A: 141-82-2
malonic acid

B: 124-38-9
carbon dioxide

C: 64-19-7
acetic acid

Conditions

Conditions	Yield
With dihydrogen peroxide In water at 39.99℃; for 0.333333h; Kinetics; Thermodynamic data; Mechanism; Temperature; Time;	A 52.1% B n/a C n/a

...Expand

: 67-56-1
methanol

: 2033-24-1
cycl-isopropylidene malonate

: 485-47-2
indan-1,2,3-trione hydrate

A: 141-82-2
malonic acid

B: 2,3-Dihydro-2-hydroxy-1,3-dioxo-1H-indene-2-acetic acid methyl ester

Conditions

Conditions	Yield
Stage #1: cycl-isopropylidene malonate; indan-1,2,3-trione hydrate With montmorillonite K10 clay In methanol at 20℃; for 0.0833333h; Stage #2: methanol In ethyl acetate	A n/a B 40%

...Expand

: 2033-24-1
cycl-isopropylidene malonate

: 485-47-2
indan-1,2,3-trione hydrate

A: 141-82-2
malonic acid

B: ethyl 2,2-bis(1,3-dioxo-2,3-dihydro-1H-inden-2-yl)acetate

: 2-ethoxy-2-methyl-2H-3a,8b-(epoxyethano)indeno[1,2-b]furan-4,10(3H)-dione

Conditions

Conditions	Yield
Sonication;	A 40% B 30% C 13%

...Expand

: 1165952-92-0
cyclohexa-1,4-diene

: 141-82-2
malonic acid

Conditions

Conditions	Yield
With ozone In methanol for 1h; Product distribution; Heating; followed by reaction with aq. H2O2 / HCOOH;	30%
With formic acid; dihydrogen peroxide; ozone 1.) methanol, -40 deg C, 2.) reflux, 1 h; Yield given. Multistep reaction;

: 50-99-7
D-glucose

A: 64-18-6
formic acid

B: 79-14-1
glycolic Acid

C: 79-33-4
L-Lactic acid

D: 141-82-2
malonic acid

E: 110-15-6
succinic acid

F: 144-62-7
oxalic acid

G: 64-19-7
acetic acid

H: 802294-64-0
propionic acid

I: 127-17-3
2-oxo-propionic acid

J: 110-16-7
maleic acid

Conditions

Conditions	Yield
With sodium silicate; water at 300℃; under 64356.4 Torr; for 0.0166667h; Reagent/catalyst; Sealed tube;	A n/a B n/a C 30% D n/a E n/a F n/a G n/a H n/a I n/a J n/a

...Expand

: 2033-24-1
cycl-isopropylidene malonate

: 64-17-5
ethanol

: 485-47-2
indan-1,2,3-trione hydrate

A: 141-82-2
malonic acid

B: 1176972-62-5
ethyl (2'-hydroxyindane-1',3'-dione-2'-yl)acetate

Conditions

Conditions	Yield
Stage #1: cycl-isopropylidene malonate; indan-1,2,3-trione hydrate With montmorillonite K10 clay In ethanol at 20℃; for 0.0833333h; Stage #2: ethanol In ethyl acetate	A n/a B 25%

...Expand

: 110-83-8
cyclohexene

A: 110-62-3
pentanal

B: 692-29-5
Succinic semialdehyde

C: 141-82-2
malonic acid

D: 144-62-7
oxalic acid

Conditions

Conditions	Yield
With ozone at 24.85℃; Product distribution; in dark;	A 17.05% B 6.9% C 6.88% D 6.16%

...Expand

: 110-16-7
maleic acid

: 141-82-2
malonic acid

Conditions

Conditions	Yield
With water for 0.833333h; argon plasma-jet;	13%

: 67-52-7
BARBITURIC ACID

: 141-82-2
malonic acid

Conditions

Conditions	Yield
With potassium hydroxide

: 21577-50-4
mucobromic acid

: 141-82-2
malonic acid

Conditions

Conditions	Yield
With barium dihydroxide beim Kochen;

: 187737-37-7
propene

: 141-82-2
malonic acid

Conditions

Conditions	Yield
With potassium permanganate

: 504-64-3
carbon suboxide

: 141-82-2
malonic acid

Conditions

Conditions	Yield
With water
With water In diethyl ether C3O2 dissolved in ether;;
With water; hydrogenchloride In water
With water In water during hours;;	>99
With water In water

: 328-42-7
Oxalacetic acid

: 141-82-2
malonic acid

Conditions

Conditions	Yield
With oxygen in Gegenwart einer dialysierten Enzymloesung aus Schweineherz und von MnCl2;

: 2-cyano-3-imino-butyric acid ethyl ester

: furan-2,3,5(4H)-trione pyridine (1:1)

A: 141-82-2
malonic acid

B: 64-19-7
acetic acid

Conditions

Conditions	Yield
Kochen;

...Expand

: 1,1,1,4,4,4-hexabromo-butan-2-one

: 141-82-2
malonic acid

Conditions

Conditions	Yield
With nitric acid

: 90-46-0
9-hydroxyxanthene

: 141-82-2
malonic acid

: 101278-43-7
9-dicarboxymethylxanthene

Conditions

Conditions	Yield
With acetic acid at 20℃; for 1h;	100%
With acetic acid

: 13679-70-4
5-methylthiophene-2-carboxaldehyde

: 141-82-2
malonic acid

: 70329-36-1
(E)-3-(5-methyl-2-thienyl)-2-propenoic acid

Conditions

Conditions	Yield
With piperidine; pyridine Heating;	100%
With piperidine; pyridine Reflux;	66%
With piperidine; pyridine Heating / reflux;	66%

: 67-56-1
methanol

: 141-82-2
malonic acid

: 108-59-8
malonic acid dimethyl ester

Conditions

Conditions	Yield
With boron trifluoride at 65℃; for 0.333333h;	100%
zirconium(IV) oxide; molybdenum at 84.85℃; for 6h; Esterification;	95%
iodine for 15h; Heating;	94%

: 141-82-2
malonic acid

: 15356-60-2
(1S,2R,5S)-(+)-menthol

: 73636-64-3, 131348-66-8, 141611-48-5
Malonsaeure-bis<(1R)-menthyl>ester

Conditions

Conditions	Yield
With dicyclohexyl-carbodiimide In diethyl ether for 2h; Ambient temperature;	100%
at 100℃; Einleiten von HCl;

: 141-82-2
malonic acid

: 555-16-8
4-nitrobenzaldehdye

: 882-06-4
4-nitro-trans-cinnamic acid

Conditions

Conditions	Yield
With pyridine In ethanol for 1.75h; Knoevenagel condensation; Inert atmosphere; Reflux;	100%
With ammonium acetate for 0.0666667h; Irradiation;	95%
Stage #1: malonic acid; 4-nitrobenzaldehdye With piperidine; pyridine Knoevenagel-Doebner reaction; Reflux; Stage #2: With hydrogenchloride In water Cooling with ice; optical yield given as %de;	95%

: 141-82-2
malonic acid

: 66-99-9
β-naphthaldehyde

: 49711-14-0
(E)-3-(naphthalen-2-yl)acrylic acid

Conditions

Conditions	Yield
With piperidine; pyridine	100%
With piperidine; pyridine at 115℃; for 3h; Knoevenagel Condensation;	93%
With pyridine for 1h; Heating;	82%

: 141-82-2
malonic acid

: 2043-61-0
cyclohexanecarbaldehyde

: 4484-35-9
3-cyclohexylacrylic acid

Conditions

Conditions	Yield
Stage #1: malonic acid; cyclohexanecarbaldehyde With piperidine; pyridine at 20 - 80℃; for 6h; Doebner reaction; Stage #2: With hydrogenchloride In water Cooling with ice;	100%
With piperidine; pyridine	97%
With piperidine; pyridine

: 455-19-6
4-Trifluoromethylbenzaldehyde

: 141-82-2
malonic acid

: 16642-92-5, 87212-84-8, 2062-26-2
4-(trifluoromethyl)cinnamic acid

Conditions

Conditions	Yield
With pyridine; aniline In toluene for 18h; Doebner Modification; Reflux;	100%
With pyridine; ammonium acetate at 85℃; for 5h; Darkness;	65.36%

: 99845-89-3
3-formyl-5,5'-dimethyl-2,2'-bithiophene

: 141-82-2
malonic acid

: 5,5'-dimethyl-2,2'-bithien-3-ylacrylic acid

Conditions

Conditions	Yield
With piperidine; pyridine for 2h; Heating;	100%

: 141-82-2
malonic acid

: 24973-22-6
3-methoxy-4-methylbenzaldehyde

: 132980-20-2
3-(3-Methoxy-4-methylphenyl)-2-propenoic acid

Conditions

Conditions	Yield
Stage #1: malonic acid; 3-methoxy-4-methylbenzaldehyde With piperidine; pyridine for 2.5h; Heating / reflux; Stage #2: With hydrogenchloride In water	100%
In piperidine; pyridine for 2.5h; Heating / reflux;	100%
With piperidine; pyridine for 5h; Heating;	99.7%

: 141-82-2
malonic acid

: 93656-82-7
1-methoxypyrene-8-carboxaldehyde

: 3-(1-methoxypropen-8-yl)-2-propenoic acid

Conditions

Conditions	Yield
With piperidine; pyridine 1.) from 80 deg C to 85 deg C, 30 min, 2.) reflux, 4 h;	100%

: 141-82-2
malonic acid

: 64-19-7
acetic acid

Conditions

Conditions	Yield
copper(I) oxide In dimethyl sulfoxide at 110 - 120℃; for 1.5h; Product distribution / selectivity;	100%
copper(I) oxide In N,N-dimethyl-formamide at 110 - 120℃; for 1.5h; Product distribution / selectivity;	100%
In neat (no solvent) at 141℃; Kinetics; Thermodynamic data; ΔH(excit.), ΔS(excit.), ΔF(excit.); further solvent;

: 141-82-2
malonic acid

: 123-08-0
4-hydroxy-benzaldehyde

: 7400-08-0
para-coumaric acid

Conditions

Conditions	Yield
With pyridine; glycine at 80℃; for 3h; Catalytic behavior; Reagent/catalyst; Sealed tube;	100%
With triton-B adsorbed on flyash In neat (no solvent) for 0.0152778h; Microwave irradiation; Green chemistry;	96%
Stage #1: malonic acid With triethylamine In toluene Knoevenagel Condensation; Stage #2: 4-hydroxy-benzaldehyde With piperidine In toluene for 2h; Knoevenagel Condensation; Reflux;	88%

: 141-82-2
malonic acid

: 1571-08-0
methyl 4-formylbenzoate

: 19473-96-2
4-(2-carboxyvinyl)benzoic acid methyl ester

Conditions

Conditions	Yield
With piperidine; pyridine at 120℃; for 12h;	100%
With piperidine In pyridine at 100 - 120℃; for 19h;	99.39%
With piperidine; pyridine at 80 - 100℃; for 4h;	91.6%
With piperidine; pyridine at 110℃; for 2h;	75%
With piperidine; pyridine for 5h; Reflux;	36%

: 141-82-2
malonic acid

: 183145-78-0
[tert-Butoxycarbonyl-(2-formyl-phenyl)-amino]-acetic acid methyl ester

: 183145-79-1
(E)-3-[2-(tert-Butoxycarbonyl-methoxycarbonylmethyl-amino)-phenyl]-acrylic acid

Conditions

Conditions	Yield
With piperidine; pyridine for 1h; Ambient temperature;	100%

: 141-82-2
malonic acid

: 24973-22-6
3-methoxy-4-methylbenzaldehyde

: 209287-19-4
ferulic acid

Conditions

Conditions	Yield
With piperidine; pyridine for 2.5h; Heating / reflux; Neat (no solvent);	100%
With piperidine; pyridine for 2.5h; Heating / reflux;	100%
With piperidine; pyridine at 100℃; Condensation;

: 141-82-2
malonic acid

: 104-87-0
4-methyl-benzaldehyde

: 1866-39-3
4-methylcinnamic acid

Conditions

Conditions	Yield
With pyridine; aniline In toluene for 18h; Doebner Modification; Reflux;	100%
With triton-B adsorbed on flyash In neat (no solvent) for 0.0125h; Microwave irradiation; Green chemistry;	96%
With 1,4-diaza-bicyclo[2.2.2]octane In N,N-dimethyl-formamide at 100 - 110℃; for 1.25h; Knoevenagel-Doebner-Stobbe Reaction;	95%

: 141-82-2
malonic acid

: 59565-09-2
2-(vinyloxy)ethyl isothiocyanate

: malonic acid bis-[1-(2-isothiocyanato-ethoxy)-ethyl] ester

Conditions

Conditions	Yield
at 65 - 100℃; for 0.166667h;	100%

: 18791-75-8
4-Bromothiophen-2-aldehyde

: 141-82-2
malonic acid

: 103686-16-4
trans-3-(4-bromothiophen-2-yl)propenoic acid

Conditions

Conditions	Yield
With piperidine; pyridine at 100℃;	100%
Stage #1: 4-Bromothiophen-2-aldehyde; malonic acid With piperidine; pyridine at 100℃; for 24h; Stage #2: With hydrogenchloride In water pH=3;	100%
piperidine In pyridine at 100℃; for 22h; Knoevenagel reaction;	96%

: 141-82-2
malonic acid

: 24973-22-6
3-methoxy-4-methylbenzaldehyde

: 3-(3-methyl-4-methoxy-phenyl)-acrylic acid

Conditions

Conditions	Yield
Stage #1: malonic acid; 3-methoxy-4-methylbenzaldehyde With piperidine; pyridine for 11h; Heating / reflux; Stage #2: With hydrogenchloride In water	100%

: 141-82-2
malonic acid

: 65253-04-5
(-)-8-phenylmenthol

: 75863-05-7
Bis<(1S,2R,4R)-2-methyl-5-(1-methyl-1-phenylethyl)cyclohexyl>malonate

Conditions

Conditions	Yield
With dicyclohexyl-carbodiimide In diethyl ether at 20℃; for 0.5h;	100%

: 141-82-2
malonic acid

: 52178-50-4
Methyl 3-formylbenzoate

: 98116-12-2
(E)-3-(3-methoxycarbonylphenyl)acrylic acid

Conditions

Conditions	Yield
With PYRIMIDINE In N,N-dimethyl-formamide at 90℃; for 10h; Inert atmosphere;	100%
With piperidine; pyridine Knoevenagel Condensation; Reflux;	75%
With piperidine; pyridine at 80℃; for 4h;	72%

: 141-82-2
malonic acid

: 71125-38-7
meloxicam

: 1174325-96-2
meloxicam malonic acid

Conditions

Conditions	Yield
In tetrahydrofuran for 0.5h;	100%
In tetrahydrofuran Product distribution / selectivity;

: 141-82-2
malonic acid

: 100-39-0
benzyl bromide

: 40204-26-0
malonic acid monobenzyl ester

Conditions

Conditions	Yield
With triethylamine In acetonitrile Inert atmosphere; Reflux;	100%

: (E)-3-[5,10,15,20-tetrakis(3,5-dimethylphenyl)porphyrin-2-yl]-2-propenal

: 141-82-2
malonic acid

: 557-34-6
zinc diacetate

: (2E,4E)-2-carboxy-5-(2'-(5',10',15',20'-tetra(3'',5''-dimethylphenyl)porphyrinato zinc(II))yl)-penta-2,4-dienoic acid

Conditions

Conditions	Yield
Stage #1: (E)-3-[5,10,15,20-tetrakis(3,5-dimethylphenyl)porphyrin-2-yl]-2-propenal; malonic acid With ammonium acetate; acetic acid at 70℃; for 3h; Stage #2: zinc diacetate at 70℃; for 0.25h;	100%

...Expand

: ulimorelin

: 141-82-2
malonic acid

: 1284151-33-2
C3H4O4*C30H39FN4O4

Conditions

Conditions	Yield
In water; acetone for 0.166667h;	100%

: 141-82-2
malonic acid

: ethyl 4-(2-formyl-9,10-dihydro-1-thia-benzo[f]azulen-4-ylidene)piperidine-1-carboxylate

: 1262518-41-1
3-[4-(1-ethoxycarbonylpiperidin-4-ylidene)-9,10-dihydro-4H-1-thiabenzo[f]azulen-2-yl]acrylic acid

Conditions

Conditions	Yield
With piperidine; hydrogenchloride In pyridine Reflux;	100%

: 141-82-2
malonic acid

: 139978-82-8
methyl 2,3-O-isopropylidene-α-D-mannopyranoside-4,6-cyclic sulfate

: C13H20O9

Conditions

Conditions	Yield
Stage #1: malonic acid; methyl-2,3-O-isopropylidene-4,6-cyclic sulfate-α-D-mannopyranoside With sodium hydride In N,N-dimethyl-formamide Stage #2: In tetrahydrofuran; methanol regioselective reaction;	100%

: 141-82-2
malonic acid

: 67-48-1
choline chloride

: choline malonate

Conditions

Conditions	Yield
at 100℃;	100%
at 20℃; for 24h;
at 50 - 120℃;
at 80℃;

: 141-82-2
malonic acid

: 304651-39-6
C42H36FeN4O8P2S2

: C50H40FeN4O12P2S2(4-)*4Na(1+)

Conditions

Conditions	Yield
With piperidine; pyridine at 95℃;	100%

Malonic acid Chemical Properties

Molecular Structure of Malonic acid (CAS NO. 141-82-2):

IUPAC Name: Propanedioic acid
Molecular Formula: C₃H₄O₄
Molecular Weight: 104.061460 g/mol
XLogP3: -0.8
H-Bond Donor: 2
H-Bond Acceptor: 4
Canonical SMILES: C(C(=O)O)C(=O)O
InChI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
InChIKey: OFOBLEOULBTSOW-UHFFFAOYSA-N
Index of Refraction: 1.478
Molar Refractivity: 19.07 cm³
Molar Volume: 67.3 cm³
Surface Tension: 70.5 dyne/cm
Density: 1.546 g/cm³
Flash Point: 201.9 °C
Enthalpy of Vaporization: 69.8 kJ/mol
Boiling Point: 386.8 °C at 760 mmHg
Vapour Pressure: 4.66E-07 mmHg at 25 °C
Melting Point: 132-135 °C (dec.)(lit.)
Water Solubility: 1400 g/L (20 ºC)
Storage Temp.: Store at RT.
BRN: 1751370
EINECS: 205-503-0
Product Categories: Intermediates;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;alpha,omega-Alkanedicarboxylic Acids;alpha,omega-Bifunctional Alkanes;Monofunctional & alpha,omega-Bifunctional Alkanes

Malonic acid Uses

Malonic acid (141-82-2) is used as building block in chemical synthesis. frequently used as an enolate in Knoevenagel condensations or condensed with acetone to form Meldrum's acid. Its esters are also used for the -CH₂COOH synthon in the malonic ester synthesis.

Malonic acid Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	300mg/kg (300mg/kg)		National Technical Information Service. Vol. AD277-689,
mouse	LD50	oral	4gm/kg (4000mg/kg)		Biochemical Journal. Vol. 34, Pg. 1196, 1940.
rabbit	LDLo	skin	10gm/kg (10000mg/kg)		BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 22-3/1971,
rat	LC50	inhalation	> 8900mg/m³/1H (8900mg/m³)		BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 22-3/1971,
rat	LD50	intraperitoneal	1500mg/kg (1500mg/kg)		"Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 4937, 1982.
rat	LD50	oral	1310mg/kg (1310mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA LUNGS, THORAX, OR RESPIRATION: CYANOSIS	BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 22-3/1971,

Malonic acid Safety Profile

Safety Information of Malonic acid (CAS NO. 141-82-2):
Hazard Codes: Xn,Xi Harmful
Risk Statements: 20/22-41-36/37/38-22
R20/22: Harmful by inhalation and if swallowed
R41: Risk of serious damage to the eyes
R36/37/38: Irritating to eyes, respiratory system and skin
R22:Harmful if swallowed
Safety Statements: 26-36/39-37/39-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S37/39:Wear suitable gloves and eye/face protection
S36/39:Wear suitable protective clothing and eye/face protection
S36:Wear suitable protective clothing
RIDADR: 3261
WGK Germany: 1
RTECS: OO0175000
PackingGroup: III
HS Code: 29171910
When heated to decomposition it emits acrid smoke and irritating vapors.

Malonic acid Specification

Malonic acid with cas registry number of 141-82-2 is is a carboxylic acid, also called for AI3-15375 ; Carboxyacetic acid ; Dicarboxymethane ; Kyselina malonova ; Kyselina malonova [Czech] ; MALONIC ACID ; Methanedicarboxylic acid ; NSC 8124 ; Propanedioic acid ; USAF EK-695 . It can be prepared in this way: Sodium carbonate generates the sodium salt which is then reacted with sodium cyanide to provide the cyano acetic acid salt via a nucleophilic substitution. The nitrile group can be hydrolyzed with sodium hydroxide to sodium malonate and acidification affords malonic acid.

Product Name

Malonic acid

Synthetic route

Malonic acid Chemical Properties

Malonic acid Uses

Malonic acid Toxicity Data With Reference

Malonic acid Safety Profile

Malonic acid Specification

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