Methyl bromide supplier | CasNO.74-83-9

Name
Methyl bromide
EINECS 200-813-2
CAS No. 74-83-9
Article Data294
CAS DataBase
Density 1.63 g/cm³
Solubility 1.522 g/100 mL in water
Melting Point -94 °C(lit.)
Formula CH₃Br
Boiling Point 3.8 °C at 760 mmHg
Molecular Weight 94.9388
Flash Point -34°C
Transport Information UN 1062
Appearance colourless gas with a chloroform-like odour
Safety 15-27-36/39-38-45-59-61-36/37-26-24-16-7
Risk Codes 23/25-36/37/38-48/20-50-59-68-38-20/22-11-67-66-19-12
Molecular Structure
Hazard Symbols T, N, Xn, F,F+
Synonyms Detia gas EX-M;Metylu bromek [Polish];Methylbromid [German];Meth-O-Gas;Methogas;Methane, bromo-;Kayafume;Dowfume MC-2 Fumigant;Brom-O-Sol;Methyl fume;MBX;Terr-O-Gas 100;Dowfume MC-2R;Methyl bromide [UN1062] [Poison gas];Pestmaster;Bromometano [Italian];EPA Pesticide Chemical Code 053201;M-B-R 98;Zytox;Mbc-33 Soil Fumigant;R 40B1;Methyl bromide as a structural fumigant;Terr-O-Cide II;Dowfume MC-33;Bromur di metile [Italian];Brom-methan [German];Bromomethane;RCRA waste number U029;Terabol;Methane,bromo-;Dowfume MC-2;Superior Methyl Bromide-2;Pestmaster Soil Fumigant-1;Edco;Celfume;Drexel Plant Bed Gas;Metafume;
PSA 0.00000
LogP 1.01110

Synthetic route

: 71-91-0
tetraethylammonium bromide

: 333-27-7
methyl trifluoromethanesulfonate

A: 74-83-9
methyl bromide

B: 35895-69-3
tetraethylammonium trifluoromethanesulphonate

Conditions

Conditions	Yield
In acetonitrile at 20℃; for 0.583333h; Temperature;	A n/a B 100%

...Expand

: cis-{(CH3)2Co(2,2'-bipyridine)}(ClO4)

A: 74-83-9
methyl bromide

B: 34557-54-5
methane

C: 74-84-0
ethane

Conditions

Conditions	Yield
With bromine In acetonitrile one-electron oxidn. of cis-Co complex by Br2 at 298 K; monitored by (1)H-NMR;	A 99% B <1 C 0.24%

...Expand

: trans-(CH3)2Co(11-hydroxy-2,3,9,10-tetramethyl-1,4,8,11-tetraazaundeca-1,3,8,10-tetraen-1-olate)

A: 74-83-9
methyl bromide

B: 34557-54-5
methane

C: 74-84-0
ethane

Conditions

Conditions	Yield
With bromine In acetonitrile one-electron oxidn. of trans-Co complex by Br2 at 298 K; monitored by (1)H-NMR;	A 99% B 0.15% C <1

...Expand

: 110-86-1
pyridine

: C6H12Br2O2Pt

A: 74-83-9
methyl bromide

B: 1395411-05-8
cis-Br(py)Pt(COMe)[C(OMe)(Me)]

Conditions

Conditions	Yield
In tetrahydrofuran-d8 at 55℃; for 2h;	A n/a B 98%

...Expand

: Cp(CO)2Re(CH3)2

: 75-62-7
Bromotrichloromethane

A: 74-83-9
methyl bromide

B: tricarbonylcyclopentadienylrhenium

C: C5H5(CO)2Re(CH3)Br

D: C5H5Re(CO)2(CH3)Cl

E: 67-72-1
hexachloroethane

Conditions

Conditions	Yield
With carbon monoxide In further solvent(s) Irradiation (UV/VIS); Irradiation of complex at 350-380 nm under 20 atm of CO in CBrCl3;;	A 81-87 B 97% C 78-85 D <4 E >65

...Expand

: 66-27-3
Methyl methanesulfonate

: 2857-97-8
trimethylsilyl bromide

A: 74-83-9
methyl bromide

B: 10090-05-8
trimethylsilyl methanesulfonate

Conditions

Conditions	Yield
for 6h; Heating;	A 95% B 96.5%

...Expand

: 149442-29-5
dimethyltribromostibine

A: 74-83-9
methyl bromide

B: 54553-06-9
dibromo(methyl)stibine

Conditions

Conditions	Yield
decompn. at 100°C in vac. of about 10 Torr; distn. from 130 to 134°C at 13 Torr; crystn. by cooling;	A n/a B 96%
decompn. at 100°C in vac. of about 10 Torr; distn. from 130 to 134°C at 13 Torr; crystn. by cooling;	A n/a B 96%
beim Stehenlassen;

: 66-27-3
Methyl methanesulfonate

: 506-96-7
Acetyl bromide

A: 74-83-9
methyl bromide

B: 5539-53-7
Acetyl methanesulfonate

Conditions

Conditions	Yield
at 100 - 110℃; for 1h;	A 95% B 55%

...Expand

: 512-56-1
trimethyl phosphite

: 74-83-9
methyl bromide

Conditions

Conditions	Yield
With boron tribromide; (N,N'-ethylenebis(3,5-di-tert-butylsalicylideneimine))AlBr In chloroform-d1; hexane at 20℃; for 0.5 - 24h; Product distribution / selectivity;	88%
With boron tribromide; salophen(tBu)AlBr In chloroform-d1; hexane at 20℃; for 0.5 - 24h; Product distribution / selectivity;	82%
With boron tribromide; (N,N'-propylenebis(3,5-di-tert-butylsalicylideneimine))AlBr In chloroform-d1; hexane at 20℃; for 0.5 - 24h; Product distribution / selectivity;	78%

: 2857-97-8
trimethylsilyl bromide

: 100-66-3
methoxybenzene

A: 74-83-9
methyl bromide

B: 1529-17-5
phenyltrimethylsilyl ether

Conditions

Conditions	Yield
In further solvent(s)	A 87% B 61%
In further solvent(s)	A 87% B 61%

...Expand

: CpRe(CO)2(CH3)2

: 75-62-7
Bromotrichloromethane

A: 74-83-9
methyl bromide

: dia-cyclopentadienyldibromodicarbonyl Re(III)

: CpRe(CO)2(CH3)Br

Conditions

Conditions	Yield
With CO In dichloromethane-d2 Irradiation (UV/VIS); 355-385 nm light;	A 87% B n/a C 85%

...Expand

: 67-56-1
methanol

: 74-83-9
methyl bromide

Conditions

Conditions	Yield
With bromine for 1h;	84%
With bromine; pyrographite at 180 - 400℃;
With zinc bromide-kieselguhr; bromine at 180 - 400℃;

: 22024-99-3
2-nitrobenzenesulfenyl bromide

A: 1155-00-6
bis(2-nitrophenyl)disulfide

B: 74-83-9
methyl bromide

C: 3058-47-7
methyl 2-nitrophenyl sulfide

Conditions

Conditions	Yield
With tetramethylstannane; tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran at 25℃; for 4h;	A 83% B n/a C n/a

...Expand

: 67-56-1
methanol

: 124862-13-1
P-(bromomethyl)-N,N,N',N'-tetraisopropylphosphonous diamide

A: 74-83-9
methyl bromide

B: 97135-53-0
N,N,N',N'-Tetraisopropyl-P-methylphosphonic diamide

Conditions

Conditions	Yield
multistep reaction; further (α-bromoalkyl)phosphonous diamides;	A n/a B 80%

...Expand

: 108-38-3
m-xylene

A: 74-83-9
methyl bromide

B: 121-91-5
isophthalic acid

C: 99-04-7
m-Toluic acid

Conditions

Conditions	Yield
With anthracene; oxygen; acetic acid; hydrogen bromide; cobalt(II) acetate; manganese(II) acetate In water at 180 - 195℃; under 21446.5 Torr; for 1h; Product distribution / selectivity;	A n/a B 80% C 0.8%
With oxygen; acetic acid; hydrogen bromide; cobalt(II) acetate; manganese(II) acetate In water at 180 - 195℃; under 21446.5 Torr; for 1h; Product distribution / selectivity;	A n/a B 73% C 1%

...Expand

: 63833-13-6
tris(N-carbomethoxylaminomethyl)phosphine oxide

A: 74-83-9
methyl bromide

B: tris(aminomethyl)phosphine oxide trihydrobromide

Conditions

Conditions	Yield
With hydrogen bromide for 7h; Heating;	A n/a B 73%

: 72978-28-0
Diethyl-carbamic acid 2-bromo-ethyl ester

: 121-45-9
phosphorous acid trimethyl ester

A: 74-83-9
methyl bromide

B: 2-(dimethoxyphosphinyl)ethyl diethylcarbamate

Conditions

Conditions	Yield
	A n/a B 73%

...Expand

: 34557-54-5
methane

A: 74-83-9
methyl bromide

B: 74-95-3
1,2-dibromomethane

Conditions

Conditions	Yield
With bromine at 18 - 500℃; for 0.0166667h; Gas phase;	A 70.6% B 24.7%
With hydrogen bromide; oxygen; Mg/Ru/SiO2 In water at 580℃; Conversion of starting material;
With hydrogen bromide; oxygen; Ba/Bi/Ru/SiO2 In water at 580 - 600℃; Conversion of starting material;

: 1634-04-4
tert-butyl methyl ether

: 201230-82-2
carbon monoxide

: 100-39-0
benzyl bromide

A: 74-83-9
methyl bromide

B: 507-19-7
t-butyl bromide

C: 101-41-7
benzeneacetic acid methyl ester

Conditions

Conditions	Yield
1,5-hexadienerhodium(I)-chloride dimer; potassium iodide at 75 - 90℃; under 735.5 Torr; overnight or in n-heptane;	A n/a B n/a C 68%

...Expand

: 82524-20-7
2-bromoethyl N,N-dimethylcarbamate

: 121-45-9
phosphorous acid trimethyl ester

A: 74-83-9
methyl bromide

B: 2-(dimethoxyphosphinyl)ethyl dimethylcarbamate

Conditions

Conditions	Yield
at 150℃; for 5h;	A n/a B 66%

...Expand

: 102149-67-7
{(η5-C5Me5)Os(CO)2Me}

: 7726-95-6
bromine

A: 74-83-9
methyl bromide

B: 81554-89-4
{(η5-C5Me5)Os(CO)2Br}

Conditions

Conditions	Yield
In dichloromethane-d2 (N2); electrophilic cleavage reaction by addn. of bromine to a soln. of Cp*Os(CO)2Me in CD2Cl2;; not isolated, detected by NMR;;	A 53% B 66%

...Expand

: 3279-26-3
methyl dichlorophosphite

: 81428-21-9
tribromomethyl isocyanate

A: 74-83-9
methyl bromide

B: 123368-14-9
dichlorophosphoryldibromomethyl isocyanate

Conditions

Conditions	Yield
iron(III) chloride at 115℃;	A 65% B 58%

...Expand

: 110-83-8
cyclohexene

: 74-95-3
1,2-dibromomethane

A: 74-83-9
methyl bromide

B: 74-85-1
ethene

C: 286-08-8
bicyclo[4.1.0]heptane

Conditions

Conditions	Yield
With zinc In tetrahydrofuran at 40℃; for 48h; Product distribution; other olefins; also in the presence of Zn-Cu and Zn-CuCl; other solvents; var. temp.;	A n/a B n/a C 64.2%

...Expand

: 107087-79-6
{(η5-C5Me5)Os(CO)(PMe2Ph)Me}

: 7726-95-6
bromine

A: 74-83-9
methyl bromide

B: 107087-80-9
{(η5-C5Me5)Os(CO)(PMe2Ph)Br}

Conditions

Conditions	Yield
In dichloromethane-d2 (N2); electrophilic cleavage reaction by addn. of bromine to a soln. of Cp*Os(CO)(PMe2Ph)Me in CD2Cl2;; not isolated, detected by NMR;;	A 21% B 59%

...Expand

: 1,2:5,6-di-O-isopropylidene-3-O-Me3SnCH2-α-D-glucofuranose

: 7726-95-6
bromine

A: 74-83-9
methyl bromide

B: (CH3)2((CH3)2COCH2OCHC4H4OO2C(CH3)2)OCH2SnBr

C: 1066-44-0
trimethyltin bromide

D: 67-64-1
acetone

Conditions

Conditions	Yield
In chloroform-d1 -10 °C, 15 min; not isolated, detected by NMR;	A 55% B 55% C 45% D 15%

...Expand

: 63833-12-5
tris(N-carbomethoxylaminomethyl)phosphine

A: 74-83-9
methyl bromide

B: 17919-49-2
bis(hydroxymethyl)methylphosphine oxide

C: 69741-88-4
(bromomethyl)(hydroxymethyl)methylphosphine oxide

Conditions

Conditions	Yield
With hydrogen bromide at 105 - 110℃; for 3h;	A n/a B 33.8% C 46.3%

...Expand

: 1628-89-3
2-methoxypyridine

: 14660-52-7
ethyl 5-bromovalerate

A: 74-83-9
methyl bromide

B: 82360-24-5
ethyl 5-(2-oxopyridin-1(2H)-yl)pentanoate

Conditions

Conditions	Yield
at 180℃; adding 4h, then 1h;	A n/a B 44%

...Expand

: 611-08-5
5-nitrobarbituric acid

: 74-83-9
methyl bromide

: 41613-26-7
1,3-dimethyl-5-nitrouracil

Conditions

Conditions	Yield
With sodium hydroxide; tetrabutylammomium bromide In dichloromethane at 20℃; for 24h;	100%

: 74-83-9
methyl bromide

: 75609-13-1
1,1"-trimethylenebis<4-(4-pyridyl)pyridinium> dibromide

: 75609-14-2
1',1''-trimethylene-bis(1-methyl-4,4'-bipyridinium) bromide

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 90℃; for 24h;	100%
In N,N-dimethyl-formamide at 90℃; Yield given;

: 74-83-9
methyl bromide

: 81453-81-8
1,1’-(1,4-butanediyl)bis[4,4'-bipyridinium]bis[bromide]

: C26H30N4(4+)*4Br(1-)

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 90℃; for 24h;	100%

: 74-83-9
methyl bromide

: 1,1''-(1,2-ethanediyl)-bis-4,4'-bipyridinium dibromide

: C24H26N4(4+)*4Br(1-)

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 90℃; for 24h;	100%

: 74-83-9
methyl bromide

: C25H26N4(2+)*2Br(1-)

: C27H32N4(4+)*4Br(1-)

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 90℃; for 24h;	100%

: 74-83-9
methyl bromide

: 27231-26-1
3-amino-9H-xanthen-9-one

: 126486-46-2
3-(Dimethylamino)-9H-xanthen-9-on

Conditions

Conditions	Yield
With potassium hydroxide; sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride In toluene at 50℃; for 65h;	100%

: 74-83-9
methyl bromide

: 50-06-6
phenobarbital

: 730-66-5
1,3-dimethylphenobarbital

Conditions

Conditions	Yield
With sodium hydroxide; tetrabutylammomium bromide In dichloromethane at 40℃; for 3h;	100%

: 74-83-9
methyl bromide

: 66-22-8
uracil

: 874-14-6
1,3-dimethyluracil

Conditions

Conditions	Yield
With sodium hydroxide; tetrabutylammomium bromide In dichloromethane at 40℃; for 3h;	100%

: 74-83-9
methyl bromide

: 69-89-6
xanthin

: 58-08-2
3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione

Conditions

Conditions	Yield
With solution aqueuse d'hydroxide de sodium; tetrabutylammomium bromide In dichloromethane 1)room temp. 12h 2)reflux 3h;	100%

: 75-15-0
carbon disulfide

: 74-83-9
methyl bromide

: 101-92-8
4'-Chloroacetoacetanilide

: 146140-56-9
2-(bis(methylthio)methylene)-N-(4-chlorophenyl)-3-oxobutanamide

Conditions

Conditions	Yield
Stage #1: 4'-Chloroacetoacetanilide With potassium carbonate In N,N-dimethyl-formamide at 0℃; for 0.5h; Stage #2: carbon disulfide In N,N-dimethyl-formamide at 0℃; for 1h; Stage #3: methyl bromide In N,N-dimethyl-formamide at 0 - 20℃;	100%

...Expand

: 74-83-9
methyl bromide

: 645-54-5
2-phenylthioacetamide

: S-methyl phenylthioacetimidate hydrobromide

Conditions

Conditions	Yield
In acetone	100%

: 4-dimethylamino-N,N-dimethyl-nicotinamide

: 74-83-9
methyl bromide

: 4-(dimethylamino)-3-(dimethylcarbamoyl)-1-methylpyridinium bromide

Conditions

Conditions	Yield
In acetonitrile at 20℃; for 2h;	100%

: 909295-68-7
(4-dimethylamino-pyridin-3-yl)-(2-thioxo-thiazolidin-3-yl)-methanone

: 74-83-9
methyl bromide

: 4-dimethylamino-1-methyl-3-(2-thioxo-thiazolidine-3-carbonyl)-pyridinium; bromide

Conditions

Conditions	Yield
In acetonitrile at 20℃; for 2h;	100%

: 850796-07-5
(S)-(4-tert-butyl-2-thioxothiazolidin-3-yl)[4-(dimethylamino)pyridin-3-yl]methanone

: 74-83-9
methyl bromide

: (S)-3-[(4-tert-butyl-2-thioxothiazolidin-3-yl)carbonyl]-4-(dimethylamino)-1-methylpyridinium bromide

Conditions

Conditions	Yield
In acetonitrile at 20℃; for 2h;	100%

: 74-83-9
methyl bromide

: (2,2-dimethyl-oxazolidin-3-yl)pyridin-3-yl-methanone

: 3-(2,2-dimethyl-oxazolidine-3-carbonyl)-1-methyl-pyridinium bromide

Conditions

Conditions	Yield
In acetonitrile at 50℃; for 12h;	100%

: 74-83-9
methyl bromide

: 447462-02-4
(S)-(4-benzyl-2,2-dimethyl-oxazolidin-3-yl)pyridin-3-yl-methanone

: (S)-3-(4-benzyl-2,2-dimethyl-oxazolidine-3-carbonyl)-1-methyl-pyridinium bromide

Conditions

Conditions	Yield
In acetonitrile at 50℃; for 12h;	100%

: 855342-04-0
1,4-bis(2-(4-((dimethylamino)butoxyphenyl))-(E)-1-ethenyl)benzene

: 74-83-9
methyl bromide

: 1,4-bis(2-(4-((trimethylammonium)butoxyphenyl))-(E)-1-ethenyl)benzene dibromide

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃;	100%
In tetrahydrofuran; tert-butyl methyl ether at 20℃;	100%

: 74-83-9
methyl bromide

: 956486-48-9
C47H39F6N9O4

: Br(1-)*C48H42F6N9O4(1+)

Conditions

Conditions	Yield
In acetonitrile at 80℃; for 24h;	100%
In acetonitrile at 80℃; for 24h;	100%

: 74-83-9
methyl bromide

: N,N,N',N'-tetramethyl-2,3-dibromo-2-butene-1,4-diamine

: C10H22Br2N2(2+)*2Br(1-)

Conditions

Conditions	Yield
for 48h;	100%

: 74-83-9
methyl bromide

: N-[(6-fluoro-3'-{[(3S)-3-methyl-1-piperazinyl]methyl}-3-biphenylyl)methyl]-N-methyl-3-(4-piperidinylmethyl)benzamide

Conditions

Conditions	Yield
Stage #1: 1,1-dimethylethyl (2S)-4-[(5'-{[({3-[(1-{[(1,1-dimethylethyl)oxy]carbonyl}-4-piperidinyl)methyl]phenyl}carbonyl)amino]methyl}-2'-fluoro-3-biphenylyl)methyl]-2-methyl-1-piperazinecarboxylate With sodium hydride In N,N-dimethyl-formamide at 0℃; for 0.25h; Stage #2: methyl bromide In diethyl ether; N,N-dimethyl-formamide at 20℃; for 12h; Stage #3: With hydrogenchloride; sodium hydroxide more than 3 stages;	100%

Yield

Stage #1: 1,1-dimethylethyl (2S)-4-[(5'-{[({3-[(1-{[(1,1-dimethylethyl)oxy]carbonyl}-4-piperidinyl)methyl]phenyl}carbonyl)amino]methyl}-2'-fluoro-3-biphenylyl)methyl]-2-methyl-1-piperazinecarboxylate With sodium hydride In N,N-dimethyl-formamide at 0℃; for 0.25h;
Stage #2: methyl bromide In diethyl ether; N,N-dimethyl-formamide at 20℃; for 12h;
Stage #3: With hydrogenchloride; sodium hydroxide more than 3 stages;

100%

: 74-83-9
methyl bromide

: N-[(3'-{[(3S)-3,4-dimethyl-1-piperazinyl]methyl}-6-fluoro-3-biphenylyl)methyl]-3-[(1-methyl-4-piperidinyl)methyl]benzamide

: (2S)-4-[(5'-{[({3-[(1,1-dimethyl-4-piperidiniumyl)methyl]phenyl}carbonyl)amino]methyl}-2'-fluoro-3-biphenylyl)methyl]-1,1.2-trimethylpiperazin-1-ium dibromide

Conditions

Conditions	Yield
In 2,2'-oxybis(2-methyl-propane); acetone at 20℃; for 16h;	100%

: 7440-31-5
tin

: 74-83-9
methyl bromide

: 594-27-4
tetramethylstannane

Conditions

Conditions	Yield
With {(C2H5)4N}Br In acetonitrile Electrolysis; Sn-cathode, 50°C;	100%
With {(C2H5)4N}Br In acetonitrile Electrolysis; Sn-cathode, 50°C;	100%
In water; acetonitrile Electrolysis; Sn-cathode, Pt-anode, 0.25 M Et4NClO4 in MeCN/water=7:1, 25°C, 10mA/cm**(-2); gas chromy.;

: 74-83-9
methyl bromide

: (R)-cyclohexyl-(5-dimethylaminomethyl-oxazol-2-yl)-phenyl-methanol

: 1049636-90-9
[2-((S)-cyclohexyl-hydroxy-phenyl-methyl)-oxazol-5-ylmethyl]-trimethyl-ammonium bromide

Conditions

Conditions	Yield
In tetrahydrofuran; chloroform at 50℃; for 24h;	100%

: 74-83-9
methyl bromide

: 1150267-69-8
C54H51F6N9O6

: 1150267-71-2
Br(1-)*C55H54F6N9O6(1+)

Conditions

Conditions	Yield
With sodium hydrogencarbonate In acetonitrile at 20℃; for 24h;	100%
With sodium hydrogencarbonate In acetonitrile at 20℃; for 24h;	100%

: 74-83-9
methyl bromide

: C56H44F6N10O7

: 1151655-50-3
Br(1-)*C57H47F6N10O7(1+)

Conditions

Conditions	Yield
at 50℃; for 168h;	100%

: 74-83-9
methyl bromide

: 1151655-29-6
C58H56F6N10O7

: 1152178-87-4
Br(1-)*C59H59F6N10O7(1+)

Conditions

Conditions	Yield
With sodium hydrogencarbonate In water; acetonitrile at 20℃; for 24h;	100%

: 74-83-9
methyl bromide

: 3-[(tert-butyldimethylsilyl)oxy]-17-(cyclopropylmethyl)-4,5a-epoxy-14-hydroxyl-6-(1,3-dioxolan-2-yl)morphinan

: 3-[(tert-butyldimethylsilyl)oxy]-17-(cyclopropylmethyl)-4,5a-epoxy-14-hydroxyl-6-(1,3-dioxolan-2-yl)-N-methylmorphinan bromide

Conditions

Conditions	Yield
In 1-methyl-pyrrolidin-2-one at 55 - 60℃; Cooling with ice;	100%

: 74-83-9
methyl bromide

: 1333000-79-5
5-(4-cyanophenyl)-2,7-dimethyl-3-oxo-8-(3-trifluoromethyl phenyl)-2,3,5,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidine-6-carboxylic acid 2-dimethylaminoethyl ester

: 1333000-80-8
{2-[5-(4-cyanophenyl)-2,7-dimethyl-3-oxo-8-(3-trifluoromethylphenyl)-2,3,5,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidine-6-carbonyloxy]ethyl}trimethylammonium bromide

Conditions

Conditions	Yield
In acetonitrile at 20℃;	100%
In acetonitrile at 20℃;	100%

: 74-83-9
methyl bromide

: [(iPrPNP)Rh(COE)][BF4]

: [(iPrPNP)Rh(CH3)Br][BF4]

Conditions

Conditions	Yield
In acetone for 12h; Inert atmosphere; Schlenk technique; Glovebox;	100%

: 74-83-9
methyl bromide

: [(2,6-bis-(di-tert-butylphosphinomethyl)pyridine)Rh(acetone)][BF4]

: [(2,6-bis-(di-tert-butylphosphinomethyl)pyridine)Rh(CH3)Br][BF4]

Conditions

Conditions	Yield
for 12h; Inert atmosphere; Schlenk technique; Glovebox;	100%
for 12h; Inert atmosphere; Schlenk technique; Glovebox;	100%

Methyl bromide Consensus Reports

IARC Cancer Review: Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 ,1987,p. 245.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 41 ,1986,p. 187.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 41 ,1986,p. 187.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . Reported in EPA TSCA Inventory. Community Right-To-Know List. EPA Extremely Hazardous Substances List.

Methyl bromide Standards and Recommendations

OSHA PEL: TWA 5 ppm (skin)
ACGIH TLV: TWA 1 ppm (skin); Not Classifiable as a Human Carcinogen
DFG MAK: Confirmed Animal Carcinogen with Unknown Relevance to Humans
NIOSH REL: (Monohalomethanes) Reduce to lowest level

Methyl bromide Analytical Methods

For occupational chemical analysis use NIOSH: Methyl Bromide, 2520.

Methyl bromide Specification

The Methyl bromide is an organic compound with the formula CH₃Br. The IUPAC name of this chemical is bromomethane. With the CAS registry number 74-83-9, it is also named as DL-Methylbromide. The product's category is Organics. Besides, it is colourless gas with a chloroform-like odour.

The Methyl bromide is a recognized ozone-depleting chemical. It is used extensively as a pesticide. It is widely applied as a soil sterilant, mainly for production of seed but also for some crops such as strawberries and almonds. The Methyl bromide is also a precursor in the manufacture of other chemicals as a methylating agent, and has been used as a solvent to extract oil from seeds and wool.

Physical properties about Methyl bromide are: (1)ACD/LogP: 1.15; (2)ACD/LogD (pH 5.5): 1.15; (3)ACD/LogD (pH 7.4): 1.15; (4)ACD/BCF (pH 5.5): 4.39; (5)ACD/BCF (pH 7.4): 4.39; (6)ACD/KOC (pH 5.5): 100.36; (7)ACD/KOC (pH 7.4): 100.36; (8)Index of Refraction: 1.409; (9)Molar Refractivity: 14.41 cm3; (10)Molar Volume: 58.2 cm³; (11)Polarizability: 5.71×10^-24cm³; (12)Surface Tension: 20.6 dyne/cm; (13)Density: 1.63 g/cm³; (14)Enthalpy of Vaporization: 23.91 kJ/mol; (15)Boiling Point: 3.8 °C at 760 mmHg; (16)Vapour Pressure: 1590 mmHg at 25°C.

Preparation: this chemical can be prepared by methanol. This reaction will need reagent naphthalene and bromine.

Uses of Methyl bromide: it can be used to produce 1,4-dimethyl-pyridinium; bromide by heating. It will need reagent ethanol with reaction time of 10 hours.

When you are using this chemical, please be cautious about it as the following:
It is highly flammable and harmful by inhalation and if swallowed. It is toxic by inhalation and if swallowed and danger of serious damage to health by prolonged exposure through inhalation. Please keep container tightly closed, keep away from heat and keep away from sources of ignition - No smoking. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Besides, this chemical is irritating to eyes, respiratory system and skin. It may form explosive peroxides. It very toxic to aquatic organisms and vapours may cause drowsiness and dizziness. It is possible risk of irreversible effects. When you are using it, wear suitable gloves and eye/face protection. In case of accident or if you feel unwell seek medical advice immediately (show the label where possible). Please avoid release to the environment. Refer to special instructions/safety data sheet.

You can still convert the following datas into molecular structure:
(1)SMILES: BrC
(2)InChI: InChI=1/CH3Br/c1-2/h1H3
(3)InChIKey: GZUXJHMPEANEGY-UHFFFAOYAV
(4)Std. InChI: InChI=1S/CH3Br/c1-2/h1H3
(5)Std. InChIKey: GZUXJHMPEANEGY-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
child	LCLo	inhalation	1gm/m³/2H (1000mg/m³)	BLOOD: CHANGE IN CLOTTING FACTORS	Nippon Hoigaku Zasshi. Japanese Journal of Legal Medicine. Vol. 23, Pg. 241, 1969.
dog	LDLo	oral	500mg/kg (500mg/kg)	CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP GASTROINTESTINAL: NAUSEA OR VOMITING	National Technical Information Service. Vol. OTS0528834,
guinea pig	LCLo	inhalation	300ppm/9H (300ppm)	BEHAVIORAL: MUSCLE WEAKNESS LUNGS, THORAX, OR RESPIRATION: "FIBROSIS, FOCAL (PNEUMOCONIOSIS)" SKIN AND APPENDAGES (SKIN): HAIR: OTHER	U.S. Public Health Service, Public Health Bulletin. Vol. 185, Pg. 1, 1929.
human	TCLo	inhalation	35ppm (35ppm)	BEHAVIORAL: ANOREXIA (HUMAN SKIN AND APPENDAGES (SKIN): CORROSIVE: AFTER TOPICAL EXPOSURE GASTROINTESTINAL: NAUSEA OR VOMITING	Industrial Medicine. Vol. 11, Pg. 575, 1942.
human	TDLo	skin	35gm/m³/40M-I (35000mg/m³)	SKIN AND APPENDAGES (SKIN): "DERMATITIS, IRRITATIVE: AFTER SYSTEMIC EXPOSURE"	Archives of Dermatology. Vol. 124, Pg. 917, 1988.
man	LCLo	inhalation	60000ppm/2H (60000ppm)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION GASTROINTESTINAL: NAUSEA OR VOMITING	British Journal of Industrial Medicine. Vol. 2, Pg. 24, 1945.
mouse	LC50	inhalation	1540mg/m³/2H (1540mg/m³)		"Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 81, 1982.
rabbit	LC50	inhalation	28900mg/m³/30 (28900mg/m³)		Farmakologiya i Toksikologiya Vol. 8, Pg. 140, 1973.
rat	LC50	inhalation	302ppm/8H (302ppm)	BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)	Toxicology and Applied Pharmacology. Vol. 81, Pg. 183, 1985.
rat	LD50	oral	214mg/kg (214mg/kg)		Toxicology and Applied Pharmacology. Vol. 72, Pg. 262, 1984.
rat	LD50	subcutaneous	135mg/kg (135mg/kg)		Industrial Health. Vol. 26, Pg. 101, 1988.

Product Name

Methyl bromide

Synthetic route

Methyl bromide Consensus Reports

Methyl bromide Standards and Recommendations

Methyl bromide Analytical Methods

Methyl bromide Specification

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