Nitromethane supplier | CasNO.75-52-5

This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Name
Nitromethane
EINECS 200-876-6
CAS No. 75-52-5
Article Data163
CAS DataBase
Density 1.055 g/cm³
Solubility 9.5 g/100 mL (20 °C ) in water
Melting Point -29 °C
Formula CH₃NO₂
Boiling Point 85.1 °C at 760 mmHg
Molecular Weight 61.0403
Flash Point 35 °C
Transport Information UN 1261 3/PG 2
Appearance clear liquid
Safety 41
Risk Codes 5-10-22
Molecular Structure
Hazard Symbols Xn,F,Xi
Synonyms Nitromethane [UN1261] [Flammable liquid];Nitrometan (Polish);Nitromethane(Methyl Nitrobenzene);Nitrometan;methane, nitro-;Nitrocarbol;Nitrometan [Polish];
PSA 45.82000
LogP 0.41610

Synthetic route

: 75-17-2
formaldoxime

: 75-52-5
nitromethane

Conditions

Conditions	Yield
With dihydrogen peroxide; triethylamine In tert-butyl alcohol at 60℃; under 6000.6 Torr;	96.5%

: 77-78-1
dimethyl sulfate

: 75-52-5
nitromethane

Conditions

Conditions	Yield
With sodium carbonate; sodium nitrite In water at 30℃; for 3h; Reagent/catalyst; Temperature;	84%
With sodium nitrite In water at 60℃;	75%
With water; sodium carbonate; sodium nitrite zuletzt bei 120grad;

: 75-76-3
tetramethylsilane

A: 75-52-5
nitromethane

B: 420-56-4
trimethylsilyl fluoride

Conditions

Conditions	Yield
With nitronium tetrafluoborate In sulfolane at 80℃; for 2h; Product distribution; Mechanism; other alkyl- and allylsilanes; other temperature, var. solvents;	A 80% B n/a

: 2009-83-8
6-chloro-1-hexanol

: 2483-57-0
methyl 2-nitroacetate

A: 75-52-5
nitromethane

B: 124-38-9
carbon dioxide

C: 6-chlorohexyl 2-nitroacetate

Conditions

Conditions	Yield
With di(n-butyl)tin oxide at 100℃; for 1.5h; Sealed tube; Inert atmosphere;	A n/a B n/a C 76%

...Expand

: 111-87-5
octanol

: 2483-57-0
methyl 2-nitroacetate

A: 75-52-5
nitromethane

B: 124-38-9
carbon dioxide

C: octyl 2-nitroacetate

Conditions

Conditions	Yield
With di(n-butyl)tin oxide at 100℃; for 1.5h; Catalytic behavior; Reagent/catalyst; Temperature; Sealed tube; Inert atmosphere;	A n/a B n/a C 69%

...Expand

: 74-88-4
methyl iodide

A: 75-52-5
nitromethane

B: 624-91-9
methyl nitrite

Conditions

Conditions	Yield
With tetrabutylammonium nitrite In chloroform-d1 at 20℃;	A 67% B 28 % Spectr.
With silver(I) nitrite
With silver nitrate

: 6032-29-7
(+/-)-2-pentanol

: 2483-57-0
methyl 2-nitroacetate

A: 75-52-5
nitromethane

B: 124-38-9
carbon dioxide

C: s-pentyl 2-nitroacetate

Conditions

Conditions	Yield
With di(n-butyl)tin oxide at 100℃; for 1.5h; Sealed tube; Inert atmosphere;	A n/a B n/a C 66%

...Expand

: 2483-57-0
methyl 2-nitroacetate

: 107-18-6
allyl alcohol

A: 75-52-5
nitromethane

B: 124-38-9
carbon dioxide

C: 221116-46-7
allyl 2-nitroacetate

Conditions

Conditions	Yield
With di(n-butyl)tin oxide at 100℃; for 1.5h; Sealed tube; Inert atmosphere;	A n/a B n/a C 66%

...Expand

: 64-17-5
ethanol

: 2483-57-0
methyl 2-nitroacetate

A: 626-35-7
nitroacetic acid ethyl ester

B: 75-52-5
nitromethane

C: 124-38-9
carbon dioxide

Conditions

Conditions	Yield
With di(n-butyl)tin oxide at 100℃; for 1.5h; Catalytic behavior; Reagent/catalyst; Temperature; Sealed tube; Inert atmosphere;	A 61% B n/a C n/a

...Expand

: 66-27-3
Methyl methanesulfonate

A: 75-52-5
nitromethane

B: 624-91-9
methyl nitrite

Conditions

Conditions	Yield
With tetrabutylammonium nitrite In chloroform-d1 at 20℃;	A 60% B 29 % Spectr.

: 22755-24-4
sodium salt of nitromethane

A: 75-52-5
nitromethane

B: 1493-05-6
difluoro-nitro-methane

C: 21824-10-2
fluorotrinitromethane

Conditions

Conditions	Yield
With calcium fluoride; fluorine at -70 - -65℃;	A 24% B 20% C 45%

...Expand

: 420-37-1
trimethoxonium tetrafluoroborate

A: 75-52-5
nitromethane

B: 624-91-9
methyl nitrite

Conditions

Conditions	Yield
With tetrabutylammonium nitrite In chloroform-d1 at 20℃;	A 41% B 41 % Spectr.

: 333-27-7
methyl trifluoromethanesulfonate

A: 75-52-5
nitromethane

B: 624-91-9
methyl nitrite

Conditions

Conditions	Yield
With tetrabutylammonium nitrite In chloroform-d1 at 20℃;	A 38% B 56 % Spectr.

: sodium aci-nitroethane

A: 75-52-5
nitromethane

B: 1493-05-6
difluoro-nitro-methane

C: 17003-27-9
1-fluoro-1-nitro-ethane

Conditions

Conditions	Yield
With calcium fluoride; fluorine at -80 - -75℃;	A 24% B 20% C 23%

...Expand

: 67-56-1
methanol

: 75-52-5
nitromethane

Conditions

Conditions	Yield
With Cu(MeNO2)2+ Thermodynamic data; free energie for exchange of both ligands;
With water; sodium hydrogencarbonate; iron(II) sulfate; sodium nitrite
With sulfuric acid; sodium nitrite

: 74-83-9
methyl bromide

: 75-52-5
nitromethane

Conditions

Conditions	Yield
With sodium nitrite bei pH 6-10;

: 74-87-3
methylene chloride

: 75-52-5
nitromethane

Conditions

Conditions	Yield
With sodium nitrite bei pH 6-10;

: 60-29-7
diethyl ether

A: 75-52-5
nitromethane

B: 31890-52-5
1-ethoxy-2-nitroethane

Conditions

Conditions	Yield
With nitric acid at 400℃; Nebenprod.2:Nitroaethan;

: 624-91-9
methyl nitrite

: 75-52-5
nitromethane

Conditions

Conditions	Yield
With magnesium hydrosilicate at 120 - 130℃;

: 625-58-1
ethyl nitrate

A: 75-52-5
nitromethane

B: 624-91-9
methyl nitrite

C: 109-95-5
ethyl nitrite

Conditions

Conditions	Yield
at 160 - 219℃; Kinetics; unter vermindertem Druck.Pyrolysis;

...Expand

: 625-58-1
ethyl nitrate

A: 50-00-0
formaldehyd

B: 75-52-5
nitromethane

C: 75-07-0
acetaldehyde

Conditions

Conditions	Yield
at 95℃; unter vermindertem Druck.Photolysis;

...Expand

: 34557-54-5
methane

: 75-52-5
nitromethane

Conditions

Conditions	Yield
With nitric acid at 475℃;
With nitric acid
With oxygen; nitric acid

: 74-84-0
ethane

A: 79-24-3
Nitroethane

B: 75-52-5
nitromethane

Conditions

Conditions	Yield
at 420℃; beim Nitrieren in der Dampfphase;

: 74-84-0
ethane

: 75-52-5
nitromethane

Conditions

Conditions	Yield
bei der Nitrierung;

: 74-98-6
propane

: 75-52-5
nitromethane

Conditions

Conditions	Yield
bei der Nitrierung;
With nitric acid
With oxygen; nitric acid
With nitric acid; acetic acid In water at 235℃; under 72402.6 Torr; for 0.05h;

: 75-28-5
Isobutane

: 75-52-5
nitromethane

Conditions

Conditions	Yield
bei der Nitrierung;

: 78-78-4
methylbutane

: 75-52-5
nitromethane

Conditions

Conditions	Yield
bei der Nitrierung;

: 79-29-8
2,3-dimethylbutane

: 75-52-5
nitromethane

Conditions

Conditions	Yield
bei der Nitrierung;

: 5447-98-3
2-methyl-1-nitro-2-propanol

A: 75-52-5
nitromethane

B: 67-64-1
acetone

Conditions

Conditions	Yield
With water at 130 - 150℃;
at 245.6℃; under 55 Torr; Kinetics; Further Variations:; Pressures; Temperatures; also in the presence of free radical inhibitors;

: 625-75-2
nitroacetic acid

A: 75-52-5
nitromethane

B: 15719-64-9, 15719-76-3, 97762-63-5
methylammonium carbonate

Conditions

Conditions	Yield
at 25℃; Geschwindigkeit in saurer Loesung bei verschiedenen pH und Einfluss von verschiedenen anorganischen und organischen Salzen;
at 15℃; Geschwindigkeit in saurer Loesung bei verschiedenen pH und Einfluss von verschiedenen anorganischen und organischen Salzen;
at 15℃; Geschwindigkeit in saurer Loesung bei verschiedenen pH und Einfluss von Glucose und Rohrzucker;

: 4397-53-9
p-benzyloxybenzaldehyde

: 75-52-5
nitromethane

: 2982-55-0
(E)-1-(benzyloxy)-4-(2-nitrovinyl)benzene

Conditions

Conditions	Yield
Stage #1: p-benzyloxybenzaldehyde; nitromethane With sodium methylate In methanol at 0 - 20℃; for 0.166667h; Stage #2: With hydrogenchloride; water In methanol at 0 - 20℃; for 0.25h;	100%
Stage #1: p-benzyloxybenzaldehyde; nitromethane With sodium methylate In methanol at 0 - 20℃; for 0.166667h; Stage #2: With hydrogenchloride In methanol; water at 0 - 20℃; for 0.25h;	100%
Stage #1: p-benzyloxybenzaldehyde; nitromethane With sodium methylate In methanol at 0 - 20℃; Stage #2: With hydrogenchloride In methanol; water at 0 - 20℃;	100%

: 75-52-5
nitromethane

: 623-43-8
crotonic acid methyl ester

: 16507-06-5
methyl 3-methyl-4-nitro-butyrate

Conditions

Conditions	Yield
With N,N,N',N'-tetramethylguanidine at 20℃; for 576h;	100%
With DBN In methanol at 60℃; for 6h; Inert atmosphere;	71.44%
With methanol; potassium carbonate
With N-benzyl-trimethylammonium hydroxide In methanol
With 1,8-diazabicyclo[5.4.0]undec-7-ene In methanol Michael addition;

: 75-52-5
nitromethane

: 124-13-0
Octanal

: 4013-87-0
2-hydroxy-1-nitrononane

Conditions

Conditions	Yield
With potassium tert-butylate In tetrahydrofuran; butan-1-ol at 23℃; Inert atmosphere;	100%
With silica gel; triethylamine at 20℃; for 3h; Henry Nitro Aldol Condensation;	95%
With potassium tert-butylate In tetrahydrofuran; tert-butyl alcohol at 20℃; for 18.5h; Henry reaction;	94%

: 75-52-5
nitromethane

: 5417-17-4
2-chloro-3,4-dimethoxybenzaldehyde

: 41122-35-4
(E)-2-chloro-3,4-dimethoxy-1-(2-nitrovinyl)benzene

Conditions

Conditions	Yield
With ammonium acetate; acetic acid for 4h; Inert atmosphere; Reflux;	100%
With ammonium acetate In acetic acid for 3h; Heating;	95%
With ammonium acetate; acetic acid

: 75-52-5
nitromethane

: 104-87-0
4-methyl-benzaldehyde

: 7559-36-6
4-methyl-β-nitrostyrene

Conditions

Conditions	Yield
With C62H54N2O2; copper diacetate In ethanol at 10℃; for 48h; Henry Nitro Aldol Condensation; enantioselective reaction;	100%
With C62H48CuN2O2; copper diacetate; benzaldehyde In ethanol at 10℃; for 48h; Reagent/catalyst; Henry Nitro Aldol Condensation;	100%
With (2-hydroxyethyl)ammonium formate at 20℃; for 0.8h; Knoevenagel condensation; Ionic liquid;	95%

: 75-52-5
nitromethane

: 104-88-1
4-chlorobenzaldehyde

: 706-07-0
1-chloro-4-(2-nitrovinyl)benzene

Conditions

Conditions	Yield
With copper(II) ferrite In dimethyl sulfoxide at 120℃; for 0.0333333h; Microwave irradiation;	100%
With bridged diamino-functionalized periodic mesoporous organosilicas with high nitrogen contents at 90℃; for 5h; Henry Nitro Aldol Condensation;	99%
With acetic acid; benzylamine at 78 - 80℃; for 3.5h; Product distribution / selectivity;	97.1%

: 75-52-5
nitromethane

: 104-88-1
4-chlorobenzaldehyde

: 89979-04-4
1-(4-chlorophenyl)-2-nitroethanol

Conditions

Conditions	Yield
With polymer supported 4-DMAP at 20℃; for 0.416667h; Reagent/catalyst; Henry Nitro Aldol Condensation;	100%
With triethylamine at 80℃; for 0.0166667h; Henry reaction; microwave irradiation;	99%
With Musca acuminata (banana) peel ash In neat (no solvent) at 20℃; for 0.333333h; Henry Nitro Aldol Condensation; Green chemistry;	98%

: 75-52-5
nitromethane

: 555-16-8
4-nitrobenzaldehdye

: 18731-47-0
1-(4-nitrophenyl)-2-nitroethanol

Conditions

Conditions	Yield
With C57H78N12; copper(II) acetate monohydrate In methanol; dichloromethane for 72h; Henry reaction; Inert atmosphere;	100%
With polymer supported 4-DMAP at 20℃; for 0.333333h; Reagent/catalyst; Henry Nitro Aldol Condensation;	100%
With P(i-PrNCH2CH2)3N; magnesium sulfate for 0.0833333h; Ambient temperature;	99%

: 75-52-5
nitromethane

: 100-52-7
benzaldehyde

: 141377-54-0, 145920-96-3, 149495-00-1, 15990-45-1
2-nitro-1-phenylethan-1-ol

Conditions

Conditions	Yield
palladium/alumina at 60℃; for 1h;	100%
With 1-butyl-4-aza-1-azoniabicyclo[2.2.2]octane hydroxide In neat (no solvent) at 20℃; for 0.166667h; Reagent/catalyst; Henry Nitro Aldol Condensation; Green chemistry;	99%
With 1-butyl-4-aza-1-azoniabicyclo[2.2.2]octane hydroxide In neat (no solvent) at 20℃; for 0.166667h; Catalytic behavior; Reagent/catalyst; Henry Nitro Aldol Condensation; Ionic liquid; Green chemistry;	99%

: 75-52-5
nitromethane

: 123-72-8
butyraldehyde

: 2224-37-5
1-nitropentan-2-ol

Conditions

Conditions	Yield
With sodium hydroxide In ethanol; water at 0℃; for 0.166667h; Addition; Henry reaction;	100%
With P(i-PrNCH2CH2)3N; magnesium sulfate for 0.666667h; Ambient temperature;	98%
With rac-1',2',3',4'-tetrahydro-1,1'-bisisoquinoline In tetrahydrofuran at 20℃; for 24h; Henry Nitro Aldol Condensation;	98%

: 75-52-5
nitromethane

: 66-25-1
hexanal

: 6302-74-5
1-nitroheptan-2-ol

Conditions

Conditions	Yield
With potassium tert-butylate In tetrahydrofuran; tert-butyl alcohol at 0 - 20℃; for 24h; Henry reaction;	100%
With potassium tert-butylate In tetrahydrofuran; tert-butyl alcohol Addition;	99%
With (S,S)-1,2-diaminocyclohexane; copper(II) acetate monohydrate In ethanol at 20℃; for 12h; Henry reaction; Inert atmosphere; enantioselective reaction;	99%

: 75-52-5
nitromethane

: 94-41-7
benzalacetophenone

: 6277-67-4
4-nitro-1,3-diphenyl-butan-1-one

Conditions

Conditions	Yield
With potassium carbonate In ethanol Michael condensation; Reflux;	100%
With alkaline hydroxide In ethanol at 60℃; for 12h; Michael addition;	100%
With potassium fluoride In ethanol at 20℃; for 2h; Addition;	98%

: 75-52-5
nitromethane

: 119-67-5
o-carboxybenzaldehyde

: 3598-68-3
3-(nitromethyl)-isobenzofuran-1-(3H)-one

Conditions

Conditions	Yield
With sodium hydroxide In methanol at 15 - 30℃; for 1h;	100%
With alkaline solution

: 75-52-5
nitromethane

: 2043-61-0
cyclohexanecarbaldehyde

: 141377-56-2, 141434-99-3, 149559-83-1, 50598-90-8
1-cyclohexyl-2-nitroethanol

Conditions

Conditions	Yield
tris(bis(trimethylsilyl)amido)samarium(III) In tetrahydrofuran for 25h; Ambient temperature;	100%
With potassium fluoride In isopropyl alcohol at 0 - 20℃; for 24h; Inert atmosphere;	100%
With calcium oxide at 50℃; for 12h;	99%

: 75-52-5
nitromethane

: 108-94-1
cyclohexanone

: 100-53-8
phenylmethanethiol

: 335458-24-7
1-benzylthio-1-nitromethylcyclohexane

Conditions

Conditions	Yield
With piperidine In benzene	100%
With piperidine In acetonitrile for 4h; Heating;	96%
With piperidine In acetonitrile for 4h; Heating / reflux;	22%
With piperidine In benzene Heating;

...Expand

: 75-52-5
nitromethane

: 120-92-3
cyclopentanone

: 100-53-8
phenylmethanethiol

: 335458-23-6
1-benzylthio-1-nitromethylcyclopentane

Conditions

Conditions	Yield
With piperidine In benzene	100%
With piperidine In acetonitrile for 4h; Heating;	94%
With piperidine In benzene Heating;

...Expand

: 104-53-0
3-phenyl-propionaldehyde

: 75-52-5
nitromethane

: 141377-53-9, 141434-97-1, 149494-99-5, 85290-51-3
1-nitro-4-phenylbutan-2-ol

Conditions

Conditions	Yield
(anthracenebisresorcinol(4-):2La(3+))polymer In benzene at 20℃; for 0.333333h; Addition; nitroaldol reaction;	100%
With potassium fluoride In isopropyl alcohol at 0 - 20℃; for 24h; Inert atmosphere;	100%
With silica gel; triethylamine at 20℃; for 2h; Catalytic behavior; Reagent/catalyst; Henry Nitro Aldol Condensation;	99%

: 75-52-5
nitromethane

: 133157-50-3
2-Formyl-2,3-dihydronaphtho<1,8-bc>pyran

: 133157-51-4
1-(1-Hydroxy-2-nitroethyl)-2,3-dihydronaphtho<1,8-bc>pyran

Conditions

Conditions	Yield
With triethylamine 1) 15 min, cooling 2) 2 h, r.t.;	100%

: 75-52-5
nitromethane

: 127181-13-9
(+)-(4S,5S,6R)-6-acetamido-N-(benzyloxycarbonyl)-4,5-(isopropylidenedioxy)-3-piperidinone

: 141781-97-7
(-)-(2R,3S,4S,5R)-2-acetamido-N-(benzyloxycarbonyl)-3,4-O-isopropylidene-5-(nitromethyl)-3,4,5-piperidinetriol

Conditions

Conditions	Yield
With sodium hydride In 1,2-dimethoxyethane for 2h; Ambient temperature;	100%

: 75-52-5
nitromethane

: 94-41-7
benzalacetophenone

A: 6277-67-4, 68047-61-0, 122348-60-1, 77670-36-1
(R)-1,3-diphenyl-4-nitrobutane-1-one

B: 6277-67-4, 77670-36-1, 122348-60-1, 68047-61-0
(S)-4-nitro-1,3-diphenylbutan-1-one

Conditions

Conditions	Yield
With (+)-quinidine-acrylonitrile copolymer In toluene under 661957 Torr; for 5h;	A n/a B 100%
With 1-[3,5-bis(trifluoromethyl)phenyl]-3-[(1S,2S)-2-(dimethylamino)cyclohexyl]thiourea In toluene at 20℃; for 192h; Kinetics; Reagent/catalyst; Michael addition; enantioselective reaction;
Stage #1: nitromethane With (1R,1'R,2S,2'S)-1,1'-(propane-1,3-diyl)bis(2-((2,6-diisopropylphenyl)carbamoyl)pyrrolidine-1-oxide); ytterbium(III) triflate In tetrahydrofuran at 30℃; for 0.5h; Asymmetric Michael addition; Inert atmosphere; Stage #2: benzalacetophenone With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 30℃; for 48h; Asymmetric Michael addition; Inert atmosphere; optical yield given as %ee; enantioselective reaction;

...Expand

: 75-52-5
nitromethane

: 529-20-4
2-methylphenyl aldehyde

: 28638-59-7, 34222-71-4
methyl-2 β-nitrostyrene

Conditions

Conditions	Yield
ammonium acetate at 90℃; for 2h;	100%
With sodium hydroxide

: 75-52-5
nitromethane

: 100-53-8
phenylmethanethiol

: 67-64-1
acetone

: 105780-12-9
benzyl(2-methyl-1-nitropropan-2-yl)sulfane

Conditions

Conditions	Yield
With piperidine In benzene	100%
With piperidine In tetrahydrofuran for 12h; Heating;	96%
With piperidine for 15h; Heating;	49%
In benzene at 100℃; for 22h; Dean-Stark;	23%
With piperidine In benzene for 10h; Reflux; Inert atmosphere;

...Expand

: 75-52-5
nitromethane

: 122-57-6
1-Phenylbut-1-en-3-one

: 122348-55-4, 122348-59-8, 142232-08-4, 1574-86-3
5-nitro-4-phenylpentan-2-one

Conditions

Conditions	Yield
With hydrotalcite for 0.1h; Michael addition; Microwave irradiation;	100%
With potassium fluoride; 18-crown-6 ether In acetonitrile for 168h; Heating;	93%
With C10H20NaO5*HO(1-); water In methanol at 25℃; for 0.833333h; Michael addition;	90%

: 75-52-5
nitromethane

: 33985-40-9, 58056-24-9, 63029-10-7, 105368-48-7, 141610-28-8, 141724-46-1
1-O-methyl-2,3-O-isopropylidene-α-D-mannopentoaldo-1,4-furanose

: 85339-08-8, 85339-09-9, 118205-71-3, 118205-72-4, 124648-90-4, 129443-53-4
6-Deoxy-2,3-O-isopropylidene-6-nitro-α-D-lyxo-hexofuranoside

Conditions

Conditions	Yield
With sodium methylate In methanol at 0℃; for 2h;	100%
With sodium methylate In methanol at 0℃; for 2h;

: 75-52-5
nitromethane

: 60656-87-3
benzyloxyacetoaldehyde

: 169139-89-3
(+/-)-3-benzyloxy-1-nitropropan-2-ol

Conditions

Conditions	Yield
With potassium fluoride In isopropyl alcohol at 20℃; for 15h; Addition; Henry reaction;	100%
With aluminum oxide at 21℃; for 24h;	98%
With potassium hydroxide In methanol at 20℃; for 1.5h;	88%

: 75-52-5
nitromethane

: 201684-34-6
Toluene-4-sulfonic acid 5-bromo-3-formyl-1H-indol-7-yl ester

: 126260-59-1
(E)-5-bromo-3-nitrovinyl-7-(p-toluenesulfonyloxy)indole

Conditions

Conditions	Yield
With ammonium acetate for 3h; Heating;	100%

: 75-52-5
nitromethane

: 2700-22-3
Benzylidenemalononitrile

: 3-nitro-2-phenylpropane-1,1-dicarbonitrile

Conditions

Conditions	Yield
aluminum oxide at 90℃; for 0.15h;	100%
With piperazine-grafted reduced graphene oxide (rGO-NH) In ethanol at 60℃; for 8h; Reagent/catalyst; Michael Addition;	72%
With aluminum oxide at 20 - 90℃; for 0.2h; microwave irradiation;	63%
at 60℃; for 4h; Michael Addition;
With quinidine In toluene at 20℃;

: 75-52-5
nitromethane

: methyl 2-(2-fluorobenzylidene)-2-cyanoacetate

: methyl 2-cyano-4-nitro-3-(2-fluorophenyl)butanoate

Conditions

Conditions	Yield
aluminum oxide at 90℃; for 0.15h;	100%
With aluminum oxide at 20 - 90℃; for 0.2h; microwave irradiation;	70%

: 75-52-5
nitromethane

: 211935-30-7
2-(2-Benzyloxy-3-methoxyphenyl)acetaldehyde

: 211935-31-8
1-(2-Benzyloxy-3-methoxyphenyl)-3-nitropropan-2-ol

Conditions

Conditions	Yield
With cetyltrimethylammonim bromide In sodium hydroxide	100%
With sodium hydroxide; cetyltrimethylammonim bromide Condensation; Henry condensation;	100%

: 75-52-5
nitromethane

: 209175-47-3
(1-Formyl-7-methoxy-naphthalen-2-yloxy)-acetic acid ethyl ester

: 209175-48-4
[7-Methoxy-1-((E)-2-nitro-vinyl)-naphthalen-2-yloxy]-acetic acid ethyl ester

Conditions

Conditions	Yield
With ammonium acetate for 3h; Heating;	100%

Nitromethane Consensus Reports

Reported in EPA TSCA Inventory.

Nitromethane Standards and Recommendations

OSHA PEL: TWA 100 ppm
ACGIH TLV: TWA 20 ppm; Confirmed Animal Carcinogen with Unknown Relevance to Humans
DFG MAK: 100 ppm (250 mg/m³)
DOT Classification: 3; Label: Flammable Liquid

Nitromethane Analytical Methods

For occupational chemical analysis use NIOSH: Nitromethane, 2527.

Nitromethane Specification

The Nitromethane, with the CAS registry number 75-52-5, is also known as Methane, nitro-. It belongs to the product categories of Organics; Analytical Chemistry; Solvents for HPLC & Spectrophotometry; Solvents for Spectrophotometry; Analytical Reagents for General Use; I-N, Puriss p.a.; Puriss p.a.; Reagent Grade Solvents; Reagent Semi-Bulk Solvents; Reagent Solvents; Spectrophotometric Grade Solvents; Spectrophotometric Grade Solvents; Reagent Plus(R) Solvent Grade Products; ReagentPlus(R) Solvents; Chromasolv for HplcSolvents; Chromasolv Solvents (Hplc, LC-MS); Chromasolv(R) Hplc Grade Solvents; Alpha Sort; N-O; Volatiles/ Semivolatiles; ACS Grade Solvents; ACS GradeSemi-Bulk Solvents; ACS Grade Solvents; Amber Glass Bottles; Carbon Steel Cans with NPT Threads; Solvent Bottles. Its EINECS registry number is 200-876-6. This chemical's molecular formula is CH₃NO₂ and molecular weight is 61.04. Its IUPAC name is called nitromethane. What's more, this chemical's classification code is Tumor data.

Physical properties of Nitromethane: (1)#H bond acceptors: 3; (2)Index of Refraction: 1.358; (3)Molar Refractivity: 12.7 cm³; (4)Molar Volume: 57.8 cm³; (5)Surface Tension: 25.9 dyne/cm; (6)Density: 1.055 g/cm³; (7)Flash Point: 35 °C; (8)Enthalpy of Vaporization: 31.2 kJ/mol; (9)Boiling Point: 85.1 °C at 760 mmHg; (10)Vapour Pressure: 78.6 mmHg at 25°C.

Preparation of Nitromethane: this chemical is produced industrially by treating propane with nitric acid at 350–450 °C (622–842 °F). In addition, it can be prepared in other methods that are of instructional value. The reaction of sodium chloroacetate with sodium nitrite in aqueous solution produces this compound:

ClCH₂COONa + NaNO₂ + H₂O → CH₃NO₂ + NaCl + NaHCO₃

Uses of Nitromethane: The principal use of nitromethane is as a stabilizer for chlorinated solvents, which are used in dry cleaning, semiconductor processing, and degreasing. It is also used most effectively as a solvent or dissolving agent for acrylate monomers, such as cyanoacrylates. In organic synthesis nitromethane is employed as a one carbon building block. In more specialized organic synthesis, nitromethane serves as a Michael donor, adding to α,β-unsaturated carbonyl compounds via 1,4-addition in the Michael reaction. In a minor application, nitromethane is used as a fuel in racing, particularly drag racing, as well as for rockets and model airplanes and commonly referred to in this context as "nitro". Nitromethane can also be used as a monopropellant, i.e., a fuel that burns without added oxygen. The following equation describes this process:

2 CH₃NO₂ → 2 CO + 2 H₂O + H₂ + N₂

When you are using this chemical, please be cautious about it. This chemical is harmful if swallowed. In addition, it is highly flammable and irritant. If heating may cause an explosion. In case of fire and/or explosion do not breathe fumes.

You can still convert the following datas into molecular structure:
(1)Canonical SMILES: C[N+](=O)[O-]
(2)InChI: InChI=1S/CH3NO2/c1-2(3)4/h1H3
(3)InChIKey: LYGJENNIWJXYER-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LDLo	intravenous	800mg/kg (800mg/kg)	LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), ZONAL" LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	AMA Archives of Industrial Health. Vol. 11, Pg. 102, 1955.
dog	LDLo	oral	125mg/kg (125mg/kg)	KIDNEY, URETER, AND BLADDER: CHANGES IN BOTH TUBULES AND GLOMERULI LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), ZONAL"	AMA Archives of Industrial Health. Vol. 11, Pg. 102, 1955.
guinea pig	LCLo	inhalation	5000ppm/3H (5000ppm)		Journal of Industrial Hygiene and Toxicology. Vol. 22, Pg. 315, 1940.
monkey	LCLo	inhalation	1000ppm (1000ppm)		Industrial Medicine. Vol. 16, Pg. 441, 1947.
mouse	LCLo	inhalation	18gm/m³/2H (18000mg/m³)		"Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 93, 1982.
mouse	LD50	intraperitoneal	110mg/kg (110mg/kg)		Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical Journal. For English translation, see PCJOAU. Vol. 10(6), Pg. 53, 1976.
mouse	LD50	oral	950mg/kg (950mg/kg)		Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 32(9), Pg. 9, 1967.
rabbit	LCLo	inhalation	5000ppm/6H (5000ppm)		Journal of Industrial Hygiene and Toxicology. Vol. 22, Pg. 315, 1940.
rabbit	LD	skin	> 2gm/kg (2000mg/kg)		National Technical Information Service. Vol. OTS0516767,
rabbit	LDLo	intravenous	750mg/kg (750mg/kg)		AMA Archives of Industrial Health. Vol. 11, Pg. 102, 1955.
rabbit	LDLo	oral	750mg/kg (750mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION BEHAVIORAL: ATAXIA	Journal of Industrial Hygiene and Toxicology. Vol. 22, Pg. 315, 1940.
rat	LCLo	inhalation	12750mg/m³/1H (12750mg/m³)		National Technical Information Service. Vol. OTS0516767,
rat	LD50	oral	940mg/kg (940mg/kg)		Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 32(9), Pg. 9, 1967.
rat	LDLo	intraperitoneal	1500mg/kg (1500mg/kg)		Bulletin de la Societe de Pharmacie de Lille. Vol. (1), Pg. 29, 1973.

Product Name

Nitromethane

Synthetic route

Nitromethane Consensus Reports

Nitromethane Standards and Recommendations

Nitromethane Analytical Methods

Nitromethane Specification

Related Products

Hot Products