P-cresol supplier | CasNO.106-44-5

Name
Phenol,4-methyl-
EINECS 203-398-6
CAS No. 106-44-5
Article Data1030
CAS DataBase
Density 1.034 g/cm³
Solubility 20 g/L (20 ºC)
Melting Point 32-34 °C(lit.)
Formula C₇H₈O
Boiling Point 202 °C at 760 mmHg
Molecular Weight 108.14
Flash Point 81 °C
Transport Information UN 3455 6.1/PG 2
Appearance colourless to pink crystalline
Safety 36/37/39-45-36/37
Risk Codes 24/25-34-39/23/24/25-23/24/25
Molecular Structure
Hazard Symbols T,Xi
Synonyms 4-Methylphenol;Para-cresol;p-Cresol;1-Hydroxy-4-methylbenzene;1-Methyl-4-hydroxybenzene;4-Hydroxytoluene;Paramethyl phenol;FEMA Number 2337;FEMA No. 2337;UNII-1MXY2UM8NV;p-Cresylic acid;p-Hydroxytoluene;p-Tolyl alcohol;p-Toluol;
PSA 20.23000
LogP 1.70060

Synthetic route

: 767-00-0
4-cyanophenol

: 106-44-5
p-cresol

Conditions

Conditions	Yield
With ammonium formate; palladium on activated charcoal In methanol for 2h; Ambient temperature;	100%
With 20 % Pd(OH)2/C; hydrogen In methanol at 20℃; under 760.051 Torr; for 3h;	92%
With kieselguhr; nickel-copper at 453℃; Hydrogenation;
With ethanol at 24.84℃; for 48h; Photolysis; Inert atmosphere;	99 %Chromat.
With [RuCl2(p-cymene)(P(Fur)3)] In water at 80℃; for 2h; Catalytic behavior; Green chemistry;	>99 %Chromat.

: 140-39-6
1-acetoxy-4-methylbenzene

: 106-44-5
p-cresol

Conditions

Conditions	Yield
silica gel; toluene-4-sulfonic acid In water; toluene at 80℃; for 8h;	100%
With ammonium acetate In methanol at 20℃; for 4.5h;	97%
With mesoporous silica-supported (Salen) Co(II) catalyst In methanol at 20℃; for 1h; chemoselective reaction;	95%

: 97400-46-9, 97400-47-0
4-acetyl-4-methyl-6-phenylselenocyclohex-2-enone

: 106-44-5
p-cresol

Conditions

Conditions	Yield
With dihydrogen peroxide In dichloromethane at 0℃; for 2h;	100%

: 15359-98-5
4-(tert-butoxy)toluene

: 106-44-5
p-cresol

Conditions

Conditions	Yield
With sodium iodide; cerium(III) chloride In acetonitrile at 40℃; for 3h;	100%
In methanol at 25℃; Kinetics; Quantum yield; Decomposition; Irradiation;

: 123-08-0
4-hydroxy-benzaldehyde

: 106-44-5
p-cresol

Conditions

Conditions	Yield
With hydrogen In water at 25℃; for 1h;	99%
With palladium 10% on activated carbon; water; hydrazine hydrate In ethanol at 100℃; for 24h; Reagent/catalyst;	99%
With [(C6H6)(PCy3)(CO)RuH]+*BF4−; hydrogen; phenol In 1,4-dioxane; isopropyl alcohol at 130℃; under 1520.1 Torr; for 12h; Inert atmosphere; Glovebox; Schlenk technique; chemoselective reaction;	90%

: 17902-32-8
trimethyl(4-methylphenoxy)silane

: 106-44-5
p-cresol

Conditions

Conditions	Yield
With water; bis(benzonitrile)palladium(II) dichloride for 0.05h; desilylation; microwave irradiation;	99%
With methanol; 1,3-disulfonic acid imidazolium hydrogen sulfate at 20℃; for 0.0666667h; Green chemistry;	98%
With rice husk ash supported on anatase-phase titania nanoparticles nanocomposite In methanol at 20℃; for 0.05h;	94%

: 62790-85-6
tert-Butyl(dimethyl)-(4-methylphenoxy)silane

: 106-44-5
p-cresol

Conditions

Conditions	Yield
With potassium hydrogen difluoride; 18-crown-6 ether In acetonitrile at 20℃; for 24h;	99%
With sodium phosphate dodecahydrate In N,N-dimethyl-formamide at 20℃; for 1.8h;	97%
With SO3H silica gel In n-heptane at 50℃; for 0.5h;	96%

: 5720-05-8
4-methylphenylboronic acid

: 106-44-5
p-cresol

Conditions

Conditions	Yield
With oxygen; triethylamine In 2-methyltetrahydrofuran at 20℃; under 760.051 Torr; for 24h; Green chemistry;	99%
With water In tetrahydrofuran at 100℃; for 12h;	99%
With dihydrogen peroxide at 30℃; for 5h; Green chemistry;	98%

: 25458-49-5
1-(methoxymethoxy)-4-methylbenzene

: 106-44-5
p-cresol

Conditions

Conditions	Yield
sodium hydrogen sulfate; silica gel In dichloromethane at 20℃; for 1.5h;	99%
With tin(IV) chloride In dichloromethane at 0℃; for 0.0333333h;	95%

: 624-31-7
4-tolyl iodide

: 106-44-5
p-cresol

Conditions

Conditions	Yield
With 2-(N,N-dimethylamino)ethanol; sodium hydroxide; silver(l) oxide In water; dimethyl sulfoxide at 100℃; for 24h; Reagent/catalyst;	99%
Stage #1: 4-tolyl iodide With copper(l) iodide; 2-methyl-8-quinolinol; tetra(n-butyl)ammonium hydroxide In water; dimethyl sulfoxide at 100℃; for 7h; Stage #2: With hydrogenchloride In water; N,N-dimethyl-formamide at 20℃;	97%
Stage #1: 4-tolyl iodide With copper(l) iodide; 1,10-Phenanthroline; potassium hydroxide In water; dimethyl sulfoxide at 20 - 100℃; Inert atmosphere; Stage #2: With hydrogenchloride In water; dimethyl sulfoxide at 20℃; Inert atmosphere;	96%

: 623-05-2
(4-hydroxyphenyl)methanol

A: 106-44-5
p-cresol

B: C6H10O

Conditions

Conditions	Yield
With palladium dichloride In methanol at 40℃; for 24h; Inert atmosphere; Green chemistry; chemoselective reaction;	A 99% B 99%

: 92907-14-7
p-Chlor-cinnamyl-p-tolyl-ether

: 106-44-5
p-cresol

Conditions

Conditions	Yield
With ethylmagnesium chloride; iron(II) chloride In tetrahydrofuran; m-xylene at 20℃; for 1h;	99%

: 15149-10-7
2-(4-methylphenoxy)ethanol

: 106-44-5
p-cresol

Conditions

Conditions	Yield
With potassium hydroxide In dimethyl sulfoxide at 100℃; for 3h; Schlenk technique;	99%

: 13481-09-9
2-(4-methylphenoxy)tetrahydro-2H-pyran

: 106-44-5
p-cresol

Conditions

Conditions	Yield
With methanol at 20℃; for 0.5h;	98%
With Montmorillonite KSF In methanol at 40 - 50℃; for 0.4h;	97%
With methanol; zirconium(IV) chloride at 20℃; for 2h;	97%

: 23431-48-3
allyl p-tolyl ether

: 106-44-5
p-cresol

Conditions

Conditions	Yield
With chloro-trimethyl-silane; sodium iodide In acetonitrile for 0.0333333h;	98%
With ethylmagnesium chloride; iron(II) chloride In tetrahydrofuran; m-xylene at 20℃; for 1h;	97%
With iodine at 20℃;	92%
With tetrachlorosilane; borontrifluoride acetic acid; lithium iodide In toluene; acetonitrile at 70℃; for 6h;	90%
With 12-TPA/SBA 15 In 1,4-dioxane at 110℃;	74%

: 5720-05-8
4-methylphenylboronic acid

: 7722-84-1
dihydrogen peroxide

: 106-44-5
p-cresol

Conditions

Conditions	Yield
With ammonium bicarbonate In water at 20℃; for 2h; Schlenk technique;	98%

: 60222-64-2
4-(p-tolyloxy)butan-1-ol

: 106-44-5
p-cresol

Conditions

Conditions	Yield
With potassium hydroxide In dimethyl sulfoxide at 100℃; for 3h; Schlenk technique;	98%

: 104-93-8
4-Methylanisole

: 106-44-5
p-cresol

Conditions

Conditions	Yield
With 1,3-dimethyl-2-imidazolidinone; lithium diisopropyl amide In tetrahydrofuran; n-heptane; ethylbenzene at 185℃; for 12h; further reagent: NaN(SiMe3)2; various temperatures - 65-185 deg C;	97%
With N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydride; N-methylaniline In diethyl ether; xylene at 120℃; for 6.5h;	95%
With copper(I) oxide; sodium methylate In methanol at 185℃; for 12h; Autoclave;	89%

: 62790-85-6
tert-Butyl(dimethyl)-(4-methylphenoxy)silane

Cs2CO3: Cs2CO3

: 106-44-5
p-cresol

Conditions

Conditions	Yield
In water; N,N-dimethyl-formamide at 20℃; for 2.5h;	97%

: 4-Methyl-4-nitro-pentanoic acid p-tolyl ester

A: 5165-27-5
1-Hydroxy-5,5,-dimethyl-1-pyrolid-2-one

B: 106-44-5
p-cresol

Conditions

Conditions	Yield
With ammonium chloride; zinc In methanol Heating;	A n/a B 96%

: 128-37-0
2,6-di-tert-butyl-4-methyl-phenol

A: 106-44-5
p-cresol

B: 98-51-1
4-tert-butyltoluene

Conditions

Conditions	Yield
With Nafion-H; toluene for 2h; Heating;	A 96% B 94 % Chromat.

: 128-37-0
2,6-di-tert-butyl-4-methyl-phenol

: 108-88-3
toluene

A: 106-44-5
p-cresol

B: 98-51-1
4-tert-butyltoluene

Conditions

Conditions	Yield
With Nafion-H for 2h; Heating;	A 96% B 94 % Chromat.

...Expand

: 70989-48-9
2-thioxo-benzooxazole-3-carboximidic acid p-tolyl ester

A: 2382-96-9
benzo[d]oxazole-2-(3H)-thione

B: 106-44-5
p-cresol

Conditions

Conditions	Yield
With hydrogenchloride; sodium hydroxide In ethanol for 0.5h; Heating;	A 95% B n/a
With hydrogenchloride for 7h; Heating;	A 93% B n/a

: 36719-51-4
3,3-diethyl-1-(4-methylphenyl)-1-triazene

: 106-44-5
p-cresol

Conditions

Conditions	Yield
With water; sulfonic acid resin (H+ form) In acetonitrile for 0.166667h; Heating;	95%

: 142605-86-5
6,6-bis(4-methylphenyl)-3-methyl-1,2-dioxan-3-ol

A: 106-44-5
p-cresol

B: 13901-86-5
1-[4-(methyl)phenyl]pentane-1,4-dione

Conditions

Conditions	Yield
With hydrogenchloride In acetic acid at 80℃; for 0.333333h;	A 95% B 67%

: 5720-05-8
4-methylphenylboronic acid

: acetonitrile complex of hypofluorous acid

: 106-44-5
p-cresol

Conditions

Conditions	Yield
In dichloromethane at 20℃;	95%

: C30H22O12P2S2W2

A: 106-44-5
p-cresol

B: C22H16O11P2W2

Conditions

Conditions	Yield
With dimanganese decacarbonyl In toluene at 20℃; for 6h; Inert atmosphere; Schlenk technique;	A 94% B 95%

: 6627-55-0
2-bromo-p-cresol

: 106-44-5
p-cresol

Conditions

Conditions	Yield
With aluminium trichloride In dichloromethane; ethanethiol at 0℃; for 0.5h;	94.3%
With sodium hydroxide; nickel at 150℃; under 7600 Torr; Hydrogenation;

: 106-38-7
para-bromotoluene

: 106-44-5
p-cresol

Conditions

Conditions	Yield
With copper(I) oxide; tetra(n-butyl)ammonium hydroxide; 1,10-phenanthroline-4,7-diol In water at 110℃; for 24h; Inert atmosphere; Schlenk technique; Sealed tube; Green chemistry;	94%
Stage #1: para-bromotoluene With copper(l) iodide; 2-methyl-8-quinolinol; tetra(n-butyl)ammonium hydroxide In water; dimethyl sulfoxide at 130℃; for 21h; Stage #2: With hydrogenchloride In water; N,N-dimethyl-formamide at 20℃;	93%
Stage #1: para-bromotoluene With copper(l) iodide; cesium hydroxide; 5-bromo-2-(1H-imidazol-2-yl)pyridine In water; dimethyl sulfoxide; tert-butyl alcohol at 120℃; for 36h; Inert atmosphere; Stage #2: With hydrogenchloride In water; dimethyl sulfoxide; tert-butyl alcohol pH=1 - 2; Inert atmosphere;	93%

: 106-44-5
p-cresol

: 589-91-3
p-methylcyclohexanol

Conditions

Conditions	Yield
With hydrogen In water at 20℃; under 7500.75 Torr; for 6h; Autoclave;	100%
With nickel(II) oxide; hydrogen; palladium In hexane at 80℃; under 7500.75 Torr; for 10h;	99%
With hydrogen; palladium on activated charcoal In hexane at 120℃; under 37503 Torr; Rate constant; var. solvents;

: 106-44-5
p-cresol

: 6627-55-0
2-bromo-p-cresol

Conditions

Conditions	Yield
With hydrogen bromide; acetic acid In dimethyl sulfoxide at 20℃; for 2h;	100%
With Oxone; potassium bromide In methanol at 20℃; for 4h;	99%
With N-Bromosuccinimide; sulfonic acid functionalized silica In diethyl ether; acetonitrile at 20℃; for 0.166667h;	99%

: 106-44-5
p-cresol

: 609-93-8
2,6-dinitro-p-cresol

Conditions

Conditions	Yield
With (NH4)2Ce(NO3)6 supported on pillared bentonite In water at 25℃; for 48h;	100%
With chloro-trimethyl-silane; copper(ll) sulfate pentahydrate; guanidine nitrate In acetonitrile at 20℃;	99%
With silica-acetate; dinitrogen tetraoxide In ethyl acetate for 0.333333h; Heating;	95%

: 106-44-5
p-cresol

: 108-24-7
acetic anhydride

: 140-39-6
1-acetoxy-4-methylbenzene

Conditions

Conditions	Yield
With pyridine at 100℃; for 15h;	100%
at 20℃; for 0.666667h;	100%
With pyridine at 25℃; for 12h;	100%

: 106-44-5
p-cresol

: 100-11-8
1-bromomethyl-4-nitro-benzene

: 67565-47-3
4-methylphenyl 4-nitrobenzyl ether

Conditions

Conditions	Yield
With sodium hydroxide In water for 0.00277778h; microwave irradiation;	100%
With sodium hydroxide; Aliquat 360 In dichloromethane; water at 25℃; for 24h;	89%
With potassium carbonate; acetone
With alkaline solution

: 106-44-5
p-cresol

: 407-25-0
trifluoroacetic anhydride

: 1813-29-2
4-methylphenyl trifluoroacetate

Conditions

Conditions	Yield
erbium(III) triflate In acetonitrile at 20℃; for 8h;	100%
at 100℃; Cooling with ice;	93%

: 106-44-5
p-cresol

: 99-33-2
3,5-dinitrobenoyl chloride

: 27563-96-8
3,5-dinitrobenzoate of 4-methylphenol

Conditions

Conditions	Yield
With pyridine In tetrahydrofuran for 0.333333h; Heating;	100%
With pyridine
Stage #1: p-cresol With base Stage #2: 3,5-dinitrobenoyl chloride phase transfer; Further stages.;

: 106-44-5
p-cresol

: 124-63-0
methanesulfonyl chloride

: 17177-63-8
4-tolyl mesylate

Conditions

Conditions	Yield
With triethylamine In ethyl acetate at 0 - 20℃; for 0.166667h; Green chemistry;	100%
With pyridine In dichloromethane at 0 - 20℃; Inert atmosphere;	91%
With pyridine In dichloromethane at 0 - 20℃; Inert atmosphere;	80%

: 106-44-5
p-cresol

: 106-96-7
propargyl bromide

: 5651-90-1
1-methyl-4-(2-propynyloxy)benzene

Conditions

Conditions	Yield
With potassium carbonate In acetone Reflux;	100%
Stage #1: p-cresol With potassium carbonate In N,N-dimethyl-formamide for 0.166667h; Schlenk technique; Inert atmosphere; Stage #2: propargyl bromide In N,N-dimethyl-formamide at 20℃; for 24h; Schlenk technique; Inert atmosphere;	99%
With caesium carbonate In acetonitrile	93%

: 106-44-5
p-cresol

: 2032-35-1
Bromoacetaldehyde diethyl acetal

: 66614-56-0
1-(2,2-diethoxyethoxy)-4-methylbenzene

Conditions

Conditions	Yield
Stage #1: p-cresol With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; for 0.5h; Stage #2: Bromoacetaldehyde diethyl acetal In N,N-dimethyl-formamide; mineral oil Reflux;	100%
Stage #1: p-cresol With sodium hydride In N,N-dimethyl-formamide at 0℃; for 0.166667h; Inert atmosphere; Stage #2: Bromoacetaldehyde diethyl acetal In N,N-dimethyl-formamide at 120℃; for 6h; Inert atmosphere;	98%
With potassium hydroxide In N,N-dimethyl acetamide at 20℃; Heating;	96%

: 106-44-5
p-cresol

: 2876-02-0
2,6-dideuterio-4-methylphenol

Conditions

Conditions	Yield
With perchloric acid; d(4)-methanol at 75℃; for 144h; Inert atmosphere;	100%
With water-d2; phosphorus tribromide for 5h; Yield given;
With water-d2; phosphorus tribromide Reflux;

: 106-44-5
p-cresol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 62790-85-6
tert-Butyl(dimethyl)-(4-methylphenoxy)silane

Conditions

Conditions	Yield
With 1H-imidazole In N,N-dimethyl-formamide	100%
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 16h;	99%
With 1H-imidazole; 3-butyl-1-methyl-1H-imidazol-3-ium hexafluorophosphate at 20℃; for 2h;	97%

: 106-44-5
p-cresol

: 96-32-2
bromoacetic acid methyl ester

: 38768-63-7
methyl p-tolyloxyacetate

Conditions

Conditions	Yield
With potassium carbonate In butanone for 5.5h; Heating;	100%
With caesium carbonate In N,N-dimethyl-formamide at 20℃; for 3h;	90%
With caesium carbonate In N,N-dimethyl-formamide at 20℃; for 3h;	90%
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 18h;	85%
With potassium carbonate In tetrahydrofuran at 20 - 80℃;

: 106-44-5
p-cresol

: 15933-59-2
1,1,3,3-tetramethyldisilazane

: 76058-60-1
Dimethyl-p-tolyloxy-silane

Conditions

Conditions	Yield
	100%
at 20 - 160℃; for 2h; Inert atmosphere;

: 106-44-5
p-cresol

: 107-30-2
chloromethyl methyl ether

: 25458-49-5
1-(methoxymethoxy)-4-methylbenzene

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide at 20℃; for 26h;	100%
Stage #1: p-cresol With sodium hydride In N,N-dimethyl-formamide; paraffin oil at 0 - 20℃; for 1h; Stage #2: chloromethyl methyl ether In N,N-dimethyl-formamide; paraffin oil at 20℃; for 24h;	100%
(i) NaH, DMF, (ii) /BRN= 505943/; Multistep reaction;

: 106-44-5
p-cresol

: 76-04-0
2-chloro-2,2-difluoroacetic acid

: 207803-79-0
difluoro-(4-methylphenoxy)acetic acid

Conditions

Conditions	Yield
With sodium hydride In 1,4-dioxane for 3h; Heating;	100%

: 106-44-5
p-cresol

: 40400-13-3
2-Iodobenzyl bromide

: 1-iodo-2-(4-methylphenoxymethyl)benzene

Conditions

Conditions	Yield
With potassium carbonate In acetone at 50℃;	100%
Stage #1: p-cresol With potassium carbonate In N,N-dimethyl-formamide for 0.166667h; Stage #2: 2-Iodobenzyl bromide In N,N-dimethyl-formamide at 20℃;	62%
Stage #1: p-cresol With sodium hydride In tetrahydrofuran for 0.5h; Metallation; Heating; Stage #2: 2-Iodobenzyl bromide In tetrahydrofuran for 4h; Etherification; Heating; Further stages.;	40%

: 106-44-5
p-cresol

: 24424-99-5
di-tert-butyl dicarbonate

: 104741-75-5
1-(tert-butoxycarbonyloxy)-4-methylbenzene

Conditions

Conditions	Yield
With dmap In acetonitrile at 20℃; for 0.25h; Product distribution; Further Variations:; Reagents; reaction time; Condensation;	100%
With mesoporous silica MCM-41 supported erbium(III) at 40℃; for 1.5h; Neat (no solvent); ultrasound irradiation; Inert atmosphere;	99%
With MgO-ZrO2 nanoparticle at 60℃; for 1.5h; neat (no solvent); chemoselective reaction;	92%

: 106-44-5
p-cresol

: 401-99-0
3,5-dinitrobenzotrifluoride

: 4'-methyl-3-nitro-5-trifluoromethyldiphenyl ether

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 98℃; for 3h;	100%
With potassium carbonate In N,N-dimethyl-formamide

: 106-44-5
p-cresol

: 454-73-9
1-fluoro-3-(trifluoromethyl)-5-nitrobenzene

: 4'-methyl-3-nitro-5-trifluoromethyldiphenyl ether

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 98℃; for 3h;	100%
With potassium carbonate In N,N-dimethyl-formamide

: 106-44-5
p-cresol

: 1450-14-2
1,1,1,2,2,2-hexamethyldisilane

: 17902-32-8
trimethyl(4-methylphenoxy)silane

Conditions

Conditions	Yield
In pyridine at 115℃; for 3h;	100%
With lanthanum(III) nitrate hexahydrate In acetonitrile at 20℃;	90%

: 106-44-5
p-cresol

: (permethylcyclopentadienyl-methoxo-ruthenium)2

: 1493-13-6
trifluorormethanesulfonic acid

: {C5Me5Ru(μ6-4-MeC6H4OH)}CF3SO3

Conditions

Conditions	Yield
In dichloromethane under Ar: addn. of CF3SO3H to a stirred dichloromethane soln. of ((C5(CH3)5)RuOCH3)2; stirring for 15 min at room temperature; addn. of a soln. of p-cresol in dichloromethane; stirring for 2 h;; removing of the solvent; crystallization from dichloromethane/diethyl ether; elem. anal.;	100%

...Expand

: 106-44-5
p-cresol

: 139925-54-5
trimesitylgermylamine

: 139925-56-7
trimesitylgermylparamethylphenoxide

Conditions

Conditions	Yield
In benzene addn. of p-cresol to the Ge compd. in benzene (inert gas) and heating at 120°C for 2 h; evapn. (vac.); elem. anal.;;	100%
In neat (no solvent) addn. of p-cresol to the Ge compd. in a Schlenk tube (inert gas) and heating at 166-195°C for ca. 1 h; evapn. (vac.); elem. anal.;;
In not given byproducts: NH3;

: 106-44-5
p-cresol

: 3676-97-9
tetramethyl-diphosphine disulphide

A: 6591-05-5
dimethylphosphine sulfide

B: 5553-03-7
O-(p-tolyl) dimethylphosphinothioate

Conditions

Conditions	Yield
With hydridotetakis(triphenylphosphine)rhodium(I); 1,2-bis(dimethylphosphanyl)ethane In tetrahydrofuran for 3h; Inert atmosphere; Reflux;	A n/a B 100%

...Expand

: 106-44-5
p-cresol

: 1523-15-5
2,4-dinitrophenyl benzoate

A: 614-34-6
p-cresyl benzoate

B: 14314-69-3
potassium 2,4-dinitrophenolate

Conditions

Conditions	Yield
With potassium hydrogencarbonate In N,N-dimethyl-formamide at 25℃; for 5h;	A 100% B n/a

...Expand

P-cresol Consensus Reports

Community Right-To-Know List. Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.

P-cresol Standards and Recommendations

OSHA PEL: TWA 5 ppm (skin)
ACGIH TLV: TWA 5 ppm
NIOSH REL: (Cresol) TWA 10 mg/m³
DOT Classification: 6.1; Label: Poison

P-cresol Analytical Methods

For occupational chemical analysis use NIOSH: Cresols, 2001; Phenol and p-Cresol in Urine, 8305.

P-cresol Specification

The P-cresol, with the CAS register number 106-44-5, has other names as 1-methyl-4-hydroxybenzene;4-cresol;4-methyl-pheno;cresol, para;cresol,para-isomer;femanumber2337;paracresol;para-cresol .

The physical properties of this kind of chemcial are as followings: (1)#H bond acceptors: 1 ; (2)#H bond donors: 1 ; (3)#Freely Rotating Bonds: 1 ; (4)Polar Surface Area: 20.23 ; (5)Index of Refraction: 1.545 ; (6)Molar Refractivity: 32.95 cm³ ; (7)Molar Volume: 104.1 cm³ ; (8)Polarizability: 13.06 ×10-²⁴cm³ ; (9)Surface Tension: 38.8 dyne/cm ; (10)Density: 1.038 g/cm³ ; (11)Flash Point: 81 °C ; (12)Enthalpy of Vaporization: 45.61 kJ/mol ; (13)Boiling Point: 202 °C at 760 mmHg ; (14)Vapour Pressure: 0.211 mmHg at 25°C .

It is a kind of colourless to pink crystalline with smoky and herb smellings. It is soluble in water and aqueouscaustic and other organic solvent. Natuals exsit in Ylang Ylang oil, strawberry, cheese, coffee, and cocoa.

As for its usage, it is usually used in organic synthesis, and also be the material for making the antioxidant 264 and rubber antioxidant. When in plastic industry, it could be used as phenolic resin and plasticizer and then as the disinfectant in pharmaceutics. Besides, it is used as the raw material of dyeing and pesticide. Its product categories are including the following: industrial/fine chemicals;building blocks for liquid crystals;functional materials;phenols (building blocks for liquid crystals).

Being a kind of toxic chemical, it at low levels cause damage to health and if in contact with skin or swallowed or by inhalation, it will be very dangerous. Besides, it is irritant as it may cause inflammation to the skin or other mucous membranes and may causes burns. Then, it has danger of very serious irreversible effects. So while dealing with this chemical, you should be very cautious. Wear suitable protective clothing, gloves and eye/face protection and if in case of accident or if you feel unwell seek medical advice immediately (show the label where possible). You could also get the safety information from refering to WGK Germany 1.

In addition, you could refer to the following data information to get the molecular structure:
SMILES:Cc1ccc(O)cc1
InChI:InChI=1/C7H8O/c1-6-2-4-7(8)5-3-6/h2-5,8H,1H3
InChIKey:IWDCLRJOBJJRNH-UHFFFAOYAN

Below are the toxicity information of this kind of chemcial:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LDLo	subcutaneous	80mg/kg (80mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 80, Pg. 233, 1944.
frog	LDLo	subcutaneous	150mg/kg (150mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1361, 1935.
guinea pig	LDLo	subcutaneous	200mg/kg (200mg/kg)		"Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 58, 1959.
mouse	LD50	intraperitoneal	25mg/kg (25mg/kg)		"Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 58, 1959.
mouse	LD50	oral	344mg/kg (344mg/kg)		Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 18(2), Pg. 58, 1974.
mouse	LD50	unreported	160mg/kg (160mg/kg)		British Journal of Cancer. Vol. 6, Pg. 160, 1952.
mouse	LDLo	subcutaneous	150mg/kg (150mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1361, 1935.
rabbit	LD50	skin	301mg/kg (301mg/kg)	BEHAVIORAL: TREMOR KIDNEY, URETER, AND BLADDER: OTHER CHANGES GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS	BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 5-5/1969,
rabbit	LDLo	intravenous	180mg/kg (180mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 80, Pg. 233, 1944.
rabbit	LDLo	oral	620mg/kg (620mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 80, Pg. 233, 1944.
rabbit	LDLo	subcutaneous	300mg/kg (300mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1361, 1935.

Product Name

Phenol,4-methyl-

Synthetic route

P-cresol Consensus Reports

P-cresol Standards and Recommendations

P-cresol Analytical Methods

P-cresol Specification

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