Conditions | Yield |
---|---|
With silica gel; 4-acetylamino-2,2,6,6-tetramethylpiperidine-1-oxoammonium perchlorate In dichloromethane | A 4% B 99% |
With pyridine; 4-acetylamino-2,2,6,6-tetramethylpiperidine-N-oxyl; iodine; sodium hydrogencarbonate In dichloromethane; water at 20 - 25℃; for 3h; | A 58.7% B 41.3% |
With oxygen at 120℃; for 5h; Neat (no solvent); | |
With pyridine; 4-acetylamino-2,2,6,6-tetramethyl-1-piperidinoxy; iodine; sodium hydrogencarbonate In dichloromethane; water at 20 - 22℃; for 3h; Catalytic behavior; Time; | A 71 %Chromat. B 23 %Chromat. |
With 2,6-dimethylpyridine; 4-acetylamino-2,2,6,6-tetramethyl-1-piperidinoxy; iodine; sodium hydrogencarbonate In dichloromethane; water at 20 - 22℃; for 3h; Catalytic behavior; Time; | A 12 %Chromat. B 86 %Chromat. |
Conditions | Yield |
---|---|
With potassium hydroxide | 98.6% |
With C10H10Zr(2+)*2CF3O3S(1-)*C4H8O at 80℃; for 24h; Sealed tube; | 95% |
With silica gel-immobilized perchloric acid at 80℃; for 6h; Fischer esterification; Inert atmosphere; Neat (no solvent); | 94% |
Conditions | Yield |
---|---|
With periodic acid; pyridinium chlorochromate In acetonitrile at 0 - 20℃; for 2h; | 94% |
With sodium bromite In water; acetic acid for 10h; Ambient temperature; | 91% |
With peracetic acid; sodium bromide In ethyl acetate at 39.9℃; for 2h; | 86% |
2-phenylethanol
tert-butylamine
A
phenyl-acetic acid phenethyl ester
B
2-methyl-N-phenethylpropan-2-amine
Conditions | Yield |
---|---|
With 3 A molecular sieve; potassium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; [Ru(p-cumene)Cl2]2 In toluene at 110℃; for 24h; Product distribution; Further Variations:; Catalysts; | A 7% B 88% |
With 3 A molecular sieve; potassium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; [Ru(p-cumene)Cl2]2 In toluene at 110℃; for 24h; | A 61% B n/a |
Conditions | Yield |
---|---|
With Rh(PhBP3)(H)2(NCMe); hydrogen In toluene at 20℃; under 760.051 Torr; for 0.166667h; Tishchenko reaction; | 85% |
2-phenylethanol
phenylacetylene
A
phenylacetic acid
B
phenyl-acetic acid phenethyl ester
Conditions | Yield |
---|---|
With dihydrogen peroxide; methyltrioxorhenium(VII) for 48h; | A 50% B 47% |
Conditions | Yield |
---|---|
With [RuCl2(p-cymene)(iPr2-imy)]; potassium hydroxide; tricyclohexylphosphine In 1,3,5-trimethyl-benzene at 163℃; for 18h; Inert atmosphere; | A 48% B 7% |
2-phenylethanol
di-n-propylamine
A
phenyl-acetic acid phenethyl ester
B
2-phenyl-N,N-dipropylacetamide
Conditions | Yield |
---|---|
With C15H22Cl2N2Ru; potassium tert-butylate In toluene for 24h; Inert atmosphere; Reflux; | A 21% B 44% |
2-phenylethanol
dibenzylamine
A
phenyl-acetic acid phenethyl ester
B
N,N-dibenzyl-2-phenylacetamide
Conditions | Yield |
---|---|
With C15H22Cl2N2Ru; potassium tert-butylate In toluene for 24h; Inert atmosphere; Reflux; | A 19% B 40% |
Conditions | Yield |
---|---|
With rhenium-catalyst at 149℃; under 117681 Torr; Hydrogenation; | |
With tin(II) trifluoromethanesulfonate; tris(2,4-pentanedionato)ruthenium(III); hydrogen; [2-((diphenylphospino)methyl)-2-methyl-1,3-propanediyl]bis[diphenylphosphine] In water; toluene at 160℃; under 45004.5 Torr; for 48h; Reagent/catalyst; Autoclave; | A 49 %Chromat. B 20 %Chromat. |
Conditions | Yield |
---|---|
With sulfuric acid bei der elektrolytischen Reduktion an einer Bleikathode; | |
With tin(II) trifluoromethanesulfonate; tris(2,4-pentanedionato)ruthenium(III); hydrogen; [2-((diphenylphospino)methyl)-2-methyl-1,3-propanediyl]bis[diphenylphosphine] In toluene at 160℃; under 45004.5 Torr; for 48h; Reagent/catalyst; Autoclave; | 26 %Chromat. |
Conditions | Yield |
---|---|
With triphenylstannane |
Ethyl 2-phenylethanoate
A
Phenylessigsaeurehexylester
B
phenyl-acetic acid phenethyl ester
C
phenylacetic acid octyl ester
Conditions | Yield |
---|---|
Product distribution; competition reaction with n-hexanol, n-octanol and phenylethanol; selectivity of catalysis with SiO2, also mod. with Ph-CH<(EtO)3SiO>-P(O)(OEt)(OHex) or H2SO4; |
diethyl ether
phenylacetyl chloride
benzene
A
phenyl-acetic acid phenethyl ester
Conditions | Yield |
---|---|
at 70℃; bei der Elektrolyse an einer Bleikathode.Diazotization; |
Conditions | Yield |
---|---|
at 150℃; under 117681 Torr; Hydrogenation; |
2-phenylethanol
sulfuric acid
A
phenyl-acetic acid phenethyl ester
B
benzaldehyde
C
acetic acid
D
benzoic acid
2-phenylethanol
benzyl alcohol
A
benzyl 2-phenylacetate
B
benzoic acid benzyl ester
C
2-Phenylethyl benzoate
D
phenyl-acetic acid phenethyl ester
Conditions | Yield |
---|---|
With magnesium nitride; [RuCl2(p-cymene)(iPr2-imy)]; potassium tert-butylate; tricyclohexylphosphine tetrafluoroborate In toluene at 110℃; for 24h; Schlenk technique; Inert atmosphere; |
1-Phenylethanol
2-phenylethanol
A
phenyl-acetic acid phenethyl ester
B
acetophenone
Conditions | Yield |
---|---|
With magnesium nitride; [RuCl2(p-cymene)(iPr2-imy)]; potassium tert-butylate; tricyclohexylphosphine tetrafluoroborate In toluene at 110℃; for 24h; Schlenk technique; Inert atmosphere; |
phenylacetic acid
1,1-diphenylethanol
2-phenylethanol
4-nitrobenzaldehdye
4-methoxy-benzaldehyde
4-methoxy-aniline
2,2-Dimethyl-1,3-propanediol
A
1,1-Diphenylethylene
B
4-methoxy-N-(4-nitrobenzylidene)aniline
C
p-methoxybenzaldehyde neopentyl glycol acetal
D
phenyl-acetic acid phenethyl ester
E
N-(4-methoxy benzylidene)-4-methoxyaniline
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In toluene for 48h; Inert atmosphere; Reflux; Dean-Stark; | A 99 %Spectr. B 75 %Spectr. C 72 %Spectr. D 59 %Spectr. E 5 %Spectr. |
phenylacetic acid
1,1-diphenylethanol
2-phenylethanol
4-chlorobenzaldehyde
4-nitrobenzaldehdye
4-methoxy-aniline
2,2-Dimethyl-1,3-propanediol
A
1,1-Diphenylethylene
B
4-methoxy-N-(4-nitrobenzylidene)aniline
C
2-(4-chlorophenyl)-5,5-dimethyl-1,3-dioxane
D
5,5-dimethyl-2-(4-nitro-phenyl)-[1,3]dioxane
E
N-(4-chlorobenzylidene)-4-methoxyaniline
F
phenyl-acetic acid phenethyl ester
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In toluene for 48h; Inert atmosphere; Reflux; Dean-Stark; | A 99 %Spectr. B 52 %Spectr. C 52 %Spectr. D 48 %Spectr. E 43 %Spectr. F 99 %Spectr. |
phenylacetic acid
1,1-diphenylethanol
2,4-dinitrobenzaldehyde
2-phenylethanol
4-chloro-aniline
2,2-Dimethyl-1,3-propanediol
2,4-Dimethoxybenzaldehyde
A
1,1-Diphenylethylene
B
phenyl-acetic acid phenethyl ester
C
2-(2,4-dimethoxyphenyl)-5,5-dimethyl-1,3-dioxane
D
4-chloro-N-(2,4-dinitrobenzylidene)aniline
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In toluene for 48h; Inert atmosphere; Reflux; Dean-Stark; | A 99 %Spectr. B 99 %Spectr. C 74 %Spectr. D 83 %Spectr. |
phenylacetic acid
1,1-diphenylethanol
2,4-dinitrobenzaldehyde
2-phenylethanol
4-methoxy-aniline
2,2-Dimethyl-1,3-propanediol
phenylboronic acid
A
1,1-Diphenylethylene
B
N-(2,4-dinitrobenzylidene)-4-methoxyaniline
C
phenyl-acetic acid phenethyl ester
D
5,5-dimethyl-2-phenyl-1,3,2-dioxaborinane
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In toluene for 48h; Inert atmosphere; Reflux; Dean-Stark; | A 98 %Spectr. B 93 %Spectr. C 99 %Spectr. D 99 %Spectr. |
phenylacetic acid
1,1-diphenylethanol
2,4-dinitrobenzaldehyde
2-phenylethanol
pentafluorophenylboronic acid
4-methoxy-aniline
2,2-Dimethyl-1,3-propanediol
A
1,1-Diphenylethylene
B
N-(2,4-dinitrobenzylidene)-4-methoxyaniline
C
phenyl-acetic acid phenethyl ester
D
(2,3,4,5,6-pentafluorophenyl)-5,5-dimethyl-1,3,2-dioxaborinane
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In toluene for 48h; Inert atmosphere; Reflux; Dean-Stark; | A 99 %Spectr. B 97 %Spectr. C 99 %Spectr. D 74 %Spectr. |
phenylacetic acid
1,1-diphenylethanol
2,4-dinitrobenzaldehyde
2-phenylethanol
4-methoxy-aniline
2,2-Dimethyl-1,3-propanediol
2,4-Dimethoxybenzaldehyde
A
1,1-Diphenylethylene
B
N-(2,4-dinitrobenzylidene)-4-methoxyaniline
C
phenyl-acetic acid phenethyl ester
D
2-(2,4-dimethoxyphenyl)-5,5-dimethyl-1,3-dioxane
E
N-(2,4-dimethoxybenzylidene)-4-methoxyaniline
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In toluene for 48h; Inert atmosphere; Reflux; Dean-Stark; | A 99 %Spectr. B 84 %Spectr. C 96 %Spectr. D 77 %Spectr. E 9 %Spectr. |
phenylacetic acid
1,1-diphenylethanol
2,4-dinitrobenzaldehyde
2-phenylethanol
2,2-Dimethyl-1,3-propanediol
aniline
2,4-Dimethoxybenzaldehyde
A
1,1-Diphenylethylene
B
phenyl-acetic acid phenethyl ester
C
2-(2,4-dimethoxyphenyl)-5,5-dimethyl-1,3-dioxane
D
1-(2,4-dinitrophenyl)-N-phenylmethanimine
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In toluene for 48h; Inert atmosphere; Reflux; Dean-Stark; | A 99 %Spectr. B 98 %Spectr. C 80 %Spectr. D 86 %Spectr. |
phenylacetic acid
1,1-diphenylethanol
2,4-dinitrobenzaldehyde
2-phenylethanol
cyclohexylamine
2,2-Dimethyl-1,3-propanediol
2,4-Dimethoxybenzaldehyde
A
1,1-Diphenylethylene
B
phenyl-acetic acid phenethyl ester
C
2-(2,4-dimethoxyphenyl)-5,5-dimethyl-1,3-dioxane
D
N-(2,4-dinitrobenzylidene)cyclohexanamine
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In toluene for 48h; Inert atmosphere; Reflux; Dean-Stark; | A 99 %Spectr. B 43 %Spectr. C 95 %Spectr. D 72 %Spectr. |
phenylacetic acid
1,1-diphenylethanol
2,4-dinitrobenzaldehyde
2-phenylethanol
benzaldehyde
4-methoxy-aniline
2,2-Dimethyl-1,3-propanediol
A
1,1-Diphenylethylene
B
5,5-dimethyl-2-phenyl-[1,3]dioxane
C
N-(2,4-dinitrobenzylidene)-4-methoxyaniline
D
phenyl-acetic acid phenethyl ester
E
[4-(benzylideneamino)phenyl]methanol
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In toluene for 48h; Inert atmosphere; Reflux; Dean-Stark; | A 99 %Spectr. B 79 %Spectr. C 92 %Spectr. D 98 %Spectr. E 5 %Spectr. |
methanol
phenyl-acetic acid phenethyl ester
benzeneacetic acid methyl ester
Conditions | Yield |
---|---|
With 1-butyl-3-methylimidazolium tetrachloridoferrate(III) at 146.84℃; for 6h; Reagent/catalyst; | 96.6% |
Conditions | Yield |
---|---|
With triiron dodecarbonyl; 1,1,3,3-Tetramethyldisiloxane In toluene at 100℃; for 2h; Inert atmosphere; Schlenk technique; | 85% |
phenyl-acetic acid phenethyl ester
allyl bromide
phenethyl 2-phenylpent-4-enoate
Conditions | Yield |
---|---|
With caesium hydroxide monohydrate; 2,7-bis[O(9)-allylhydrocinchonidinium-N-methyl]naphthalene dibromide In dichloromethane at -40℃; for 23h; Inert atmosphere; optical yield given as %ee; enantioselective reaction; | 77% |
phenyl-acetic acid phenethyl ester
2-phenylethyl 2-oxo-2-phenylacetate
Conditions | Yield |
---|---|
Stage #1: phenyl-acetic acid phenethyl ester With tert.-butylhydroperoxide; copper(II) oxide In water at 110℃; for 4.5h; Stage #2: With pyridine In water at 50℃; for 4h; | 61% |
phenyl-acetic acid phenethyl ester
styrene
Conditions | Yield |
---|---|
at 315 - 320℃; |
Conditions | Yield |
---|---|
at 315 - 320℃; |
phenyl-acetic acid phenethyl ester
benzylmagnesium chloride
tribenzylcarbinol
Conditions | Yield |
---|---|
With diethyl ether |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 315 - 320 °C 2: peroxybenzoic acid; chloroform / 0 °C View Scheme |
phenyl-acetic acid phenethyl ester
2-phenyl-acrylic Acid Phenethyl Ester
Conditions | Yield |
---|---|
With tetra-(n-butyl)ammonium iodide; potassium carbonate; paraformaldehyde In diethyl ether; toluene | 1.48 g (60%) |
phenyl-acetic acid phenethyl ester
allyl bromide
(+/-)-phenethyl 2-phenylpent-4-enoate
Conditions | Yield |
---|---|
With caesium hydroxide monohydrate; tetrabutylammomium bromide In dichloromethane at 0 - 20℃; for 16h; Inert atmosphere; |
Conditions | Yield |
---|---|
Stage #1: phenyl-acetic acid phenethyl ester With iron (II) stearate; ethylenediamine In toluene at 20℃; for 0.0833333h; Inert atmosphere; Schlenk technique; Stage #2: In toluene at 100℃; for 20h; Inert atmosphere; Schlenk technique; | 84 %Chromat. |
Stage #1: phenyl-acetic acid phenethyl ester With C33H58FeN3PSi2; phenylsilane In toluene at 20℃; for 4h; Inert atmosphere; Glovebox; Green chemistry; Stage #2: With sodium hydroxide In toluene for 1h; Green chemistry; |
This product should be kept tightly closed and stored in a cool dry place.
Small spills/leaks
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
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