Tetrahydrofurfuryl acetate supplier

Name
TETRAHYDROFURFURYL ACETATE
EINECS 211-296-8
CAS No. 637-64-9
Article Data28
CAS DataBase
Density 1.061 g/mL at 25 °C(lit.)
Solubility Soluble in water, ether, chloroform
Melting Point
Formula C₇H₁₂O₃
Boiling Point 194-195 °C753 mm Hg(lit.)
Molecular Weight 144.17
Flash Point 184 °F
Transport Information
Appearance
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms 2-Furanmethanol,tetrahydro-, acetate (9CI);Furfuryl alcohol, tetrahydro-, acetate(6CI,7CI,8CI);2-(Acetoxymethyl)oxolane;2-(Acetoxymethyl)tetrahydrofuran;NSC4872;Tetrahydrofurfuryl acetate;
PSA 35.53000
LogP 0.72850

Synthetic route

: 97-99-4
Tetrahydrofurfuryl alcohol

: 108-24-7
acetic anhydride

: 637-64-9
tetrahydrofurfuryl acetate

Conditions

Conditions	Yield
With phosphoric acid In acetonitrile at 50℃; for 3h;	99%
With zirconium sulfophenyl phosphonate In dichloromethane at 20℃; for 3h; Acetylation;	97%
With aluminum triflate at 20℃; for 0.00555556h;	96%

: 821-09-0
n-Pent-4-enyl alcohol

: 64-19-7
acetic acid

: 637-64-9
tetrahydrofurfuryl acetate

Conditions

Conditions	Yield
With dihydrogen peroxide; potassium iodide at 20℃; for 4h;	87%

: 97-99-4
Tetrahydrofurfuryl alcohol

: 75-36-5
acetyl chloride

: 637-64-9
tetrahydrofurfuryl acetate

Conditions

Conditions	Yield
With pyridine In chloroform for 2h; Ambient temperature;	86%
durch Veresterung;

: 97-99-4
Tetrahydrofurfuryl alcohol

: 64-19-7
acetic acid

: 637-64-9
tetrahydrofurfuryl acetate

Conditions

Conditions	Yield
With iron(III) chloride at 20℃; for 9h; Esterification;	85%
With sulfuric acid durch Veresterung;
With hydrogenchloride durch Veresterung;
With molecular sieve at 120℃; for 8h;

: 141-78-6
ethyl acetate

: 161617-56-7
2-Methoxymethoxymethyl-tetrahydro-furan

: 637-64-9
tetrahydrofurfuryl acetate

Conditions

Conditions	Yield
With indium (III) iodide for 16h; Heating;	85%

: 710-14-5
tetrahydrofurfuryl tetrahydropyranyl ether

: 75-36-5
acetyl chloride

: 637-64-9
tetrahydrofurfuryl acetate

Conditions

Conditions	Yield
With sodium iodide In acetonitrile for 6h; Ambient temperature;	84%

: 821-09-0
n-Pent-4-enyl alcohol

: 2570-63-0
thallium(III) triacetate

: 637-64-9
tetrahydrofurfuryl acetate

Conditions

Conditions	Yield
In benzene Ambient temperature;	83%
In benzene Mechanism; Heating; intramolecular cyclization of other unsaturated alcohols;	83%

: 97-99-4
Tetrahydrofurfuryl alcohol

: 127-19-5
N,N-dimethyl acetamide

: 637-64-9
tetrahydrofurfuryl acetate

Conditions

Conditions	Yield
With cerium(IV) oxide at 155℃; for 36h; Inert atmosphere; Sealed tube;	82%

: 821-09-0
n-Pent-4-enyl alcohol

: 2570-63-0
thallium(III) triacetate

A: 3265-65-4
tetrahydro-2H-pyran-3-yl acetic acid

B: 637-64-9
tetrahydrofurfuryl acetate

Conditions

Conditions	Yield
In acetic acid at 60℃; for 0.333333h;	A 32% B 30%
In acetic acid at 60℃; for 0.333333h; Mechanism; intramolecular cyclization of other unsaturated alcohols;	A 32% B 30%

...Expand

: 97-99-4
Tetrahydrofurfuryl alcohol

: 127-09-3
sodium acetate

: 637-64-9
tetrahydrofurfuryl acetate

Conditions

Conditions	Yield
With acetic acid; benzene

: 98-01-1
furfural

: 108-24-7
acetic anhydride

: 637-64-9
tetrahydrofurfuryl acetate

Conditions

Conditions	Yield
With nickel; toluene-4-sulfonic acid Hydrogenation;

furfurylidene diacetate: furfurylidene diacetate

: 637-64-9
tetrahydrofurfuryl acetate

Conditions

Conditions	Yield
With platinum Hydrogenation;

: 613-75-2
(furan-2-yl)methylene diacetate

nickel /kieselguhr: nickel /kieselguhr

A: 96-47-9
2-methyltetrahydrofuran

B: 5331-61-3
gem-diacetate de tetrahydrofurfural

C: 637-64-9
tetrahydrofurfuryl acetate

Conditions

Conditions	Yield
at 160℃; Hydrogenation;

...Expand

: 19354-27-9
methyl tetrahydrofurfuryl ether

: 75-36-5
acetyl chloride

: 637-64-9
tetrahydrofurfuryl acetate

Conditions

Conditions	Yield
With bismuth(III) chloride In dichloromethane at 20℃; for 2h;

: 98-01-1
furfural

A: 97-99-4
Tetrahydrofurfuryl alcohol

B: 637-64-9
tetrahydrofurfuryl acetate

Conditions

Conditions	Yield
With palladium on activated charcoal; hydrogen In Methyl formate at 170℃; under 52505.3 Torr; for 1h; Autoclave;	A 10%Chromat. B 34.7%Spectr.

: 98-01-1
furfural

A: 97-99-4
Tetrahydrofurfuryl alcohol

B: 7681-84-7
tetrahydrofuran-2-carbaldehyde

C: 637-64-9
tetrahydrofurfuryl acetate

Conditions

Conditions	Yield
With palladium on activated charcoal; hydrogen In Methyl formate at 170℃; under 52505.3 Torr; for 1h; Autoclave;	A 34.5%Chromat. B 10.3 %Spectr. C 24.1%Spectr.

...Expand

: 637-64-9
tetrahydrofurfuryl acetate

: 97-99-4
Tetrahydrofurfuryl alcohol

Conditions

Conditions	Yield
With ytterbium(III) triflate In isopropyl alcohol for 8h; Deacetylation; Heating;	95%
With MetProLeuAspGlnProThrAlaAlaPheLeuAspPheLeuArgSerSerGlyGlyLysProLeuTyrGluLeuProLeuAlaGluAlaArgAlaAlaMetAlaMetGlySerGlnLeuGlyAlaProProAlaAspValGlyArgIleValAspArgSerIleAspValProGlyGlyAlaValAlaLeuArgIleTyrThrProAlaThrThrLysAlaGlyGlyLeuLeuProAlaIleLeuGlnTyrHisGlyGlyGlyPheValLeuGlyAsnLeuAspThrHisGluSerIleAlaArgPheTyrCysAlaHisAlaGlyAlaValValIleSerValAspTyrArgLeuAlaProGluHisArgPheProThrGlnValGluAspSerPheAlaAlaLeuThrTrpValSerGluHisAlaSerGluLeuGlyValAspProAlaArgValAlaValAlaGlyAspSerAlaGlyGlyAsnLeuAlaThrValMetCysLeuLeuAlaLysAlaArgGlyGlyProArgIleAlaCysGlnAlaLeuLeuTyrProValAlaAspPheArgProGluGlnValTyrAlaSerHisAlaGlnPheGlyAspGlySerTyrPheLeuSerSerLysAspMetAspTrpPheArgAlaSerTyrPheThrAspValAlaSerGlnAlaAlaGluProThrAlaSerProMetAlaThrThrAspLeuSerGlyLeuProProAlaLeuValThrThrAlaGlyCysAspProLeuLeuAspGluGlyArgAlaTyrAlaAspArgLeuLysAlaAlaGlyValProValAspTyrArgCysPheGluThrThrIleHisAlaCysAlaSerPheAlaGlyThrIleProAlaGlyLeuAspMetLeuGlyPheValAlaAspTrpLeuAlaAlaHisThrLys In aq. phosphate buffer at 37℃; pH=7.5; Reagent/catalyst; Enzymatic reaction; enantioselective reaction;

Yield

With ytterbium(III) triflate In isopropyl alcohol for 8h; Deacetylation; Heating;

95%

With MetProLeuAspGlnProThrAlaAlaPheLeuAspPheLeuArgSerSerGlyGlyLysProLeuTyrGluLeuProLeuAlaGluAlaArgAlaAlaMetAlaMetGlySerGlnLeuGlyAlaProProAlaAspValGlyArgIleValAspArgSerIleAspValProGlyGlyAlaValAlaLeuArgIleTyrThrProAlaThrThrLysAlaGlyGlyLeuLeuProAlaIleLeuGlnTyrHisGlyGlyGlyPheValLeuGlyAsnLeuAspThrHisGluSerIleAlaArgPheTyrCysAlaHisAlaGlyAlaValValIleSerValAspTyrArgLeuAlaProGluHisArgPheProThrGlnValGluAspSerPheAlaAlaLeuThrTrpValSerGluHisAlaSerGluLeuGlyValAspProAlaArgValAlaValAlaGlyAspSerAlaGlyGlyAsnLeuAlaThrValMetCysLeuLeuAlaLysAlaArgGlyGlyProArgIleAlaCysGlnAlaLeuLeuTyrProValAlaAspPheArgProGluGlnValTyrAlaSerHisAlaGlnPheGlyAspGlySerTyrPheLeuSerSerLysAspMetAspTrpPheArgAlaSerTyrPheThrAspValAlaSerGlnAlaAlaGluProThrAlaSerProMetAlaThrThrAspLeuSerGlyLeuProProAlaLeuValThrThrAlaGlyCysAspProLeuLeuAspGluGlyArgAlaTyrAlaAspArgLeuLysAlaAlaGlyValProValAspTyrArgCysPheGluThrThrIleHisAlaCysAlaSerPheAlaGlyThrIleProAlaGlyLeuAspMetLeuGlyPheValAlaAspTrpLeuAlaAlaHisThrLys In aq. phosphate buffer at 37℃; pH=7.5; Reagent/catalyst; Enzymatic reaction; enantioselective reaction;

: 75-36-5
acetyl chloride

: 637-64-9
tetrahydrofurfuryl acetate

: 1,2-diacetoxy-5-iodopentane

Conditions

Conditions	Yield
With sodium iodide In acetonitrile for 24h; Ambient temperature;	88%

: 637-64-9
tetrahydrofurfuryl acetate

: 30727-26-5
2,5-Dibromo-1-pentanol acetate

Conditions

Conditions	Yield
With trimethylsilyl bromide for 48h; Heating;	87%

: 119-65-3
isoquinoline

: 637-64-9
tetrahydrofurfuryl acetate

: (5-(isoquinolin-1-yl)tetrahydrofuran-2-yl)methyl acetate

Conditions

Conditions	Yield
With sodium persulfate; [4,4’-bis(1,1-dimethylethyl)-2,2’-bipyridine-N1,N1‘]bis [3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-N]phenyl-C]iridium(III) hexafluorophosphate; trifluoroacetic acid In water at 23℃; for 2h; Minisci Aromatic Substitution; Inert atmosphere; Irradiation; regioselective reaction;	77%
With ammonium persulfate; 1-hydroxy-pyrrolidine-2,5-dione In water at 40℃; for 24h; Green chemistry;	70%
With ethanol; bis-[(trifluoroacetoxy)iodo]benzene In dimethyl sulfoxide; 1,2-dichloro-ethane at 20℃; for 12h; Schlenk technique; Inert atmosphere; Irradiation; diastereoselective reaction;	60%

: 67-56-1
methanol

: 637-64-9
tetrahydrofurfuryl acetate

A: 14152-75-1, 26528-66-5
Methyl-5-O-acetyl-2,3-dideoxy-pentofuranosid

B: 112570-93-1
Acetic acid 2-methoxy-tetrahydro-furan-2-ylmethyl ester

Conditions

Conditions	Yield
In acetic acid for 5.4h; electrolysis: platinum-plate anode, carbon-rod cathode, Et4NOTs, 30 F/mol, 0.5 A, 20 V;	A 73% B 20%

...Expand

: 3282-30-2
pivaloyl chloride

: 637-64-9
tetrahydrofurfuryl acetate

: 82131-14-4
2,2-Dimethyl-propionic acid 1-acetoxymethyl-4-iodo-butyl ester

Conditions

Conditions	Yield
With copper; sodium iodide In acetonitrile for 24h; Ambient temperature;	73%

: 637-64-9
tetrahydrofurfuryl acetate

: 113401-57-3
acetoxy-2 diiodo-1,5 pentane

Conditions

Conditions	Yield
With chloro-trimethyl-silane; sodium iodide In acetonitrile for 3h;	73%

: 3282-30-2
pivaloyl chloride

: 637-64-9
tetrahydrofurfuryl acetate

sodium iodide: sodium iodide

: 82131-14-4
2,2-Dimethyl-propionic acid 1-acetoxymethyl-4-iodo-butyl ester

Conditions

Conditions	Yield
In acetonitrile for 23h; Ambient temperature;	71%

...Expand

: 637-64-9
tetrahydrofurfuryl acetate

: 5904-80-3, 79580-69-1, 112607-21-3, 112709-12-3
(5-oxotetrahydrofuran-2-yl)methyl acetate

Conditions

Conditions	Yield
Stage #1: tetrahydrofurfuryl acetate With [bis(acetoxy)iodo]benzene In nitromethane at 0℃; Stage #2: With tert.-butylhydroperoxide In decane; nitromethane at 0 - 25℃; for 12h; Solvent;	65%
With iron(II) triflate; 2-((4R,5R)-1-((4-(tert-butyl)phenyl)sulfonyl)-4,5-diphenylimidazolidin-2-yl)-6-((4R,5R)-1-((4-(tert-butyl)phenyl)sulfonyl)-4,5-diphenylimidazolidin-2-yl)pyridine; oxygen at 60℃; under 760.051 Torr; for 48h; Catalytic behavior; Green chemistry; chemoselective reaction;	5.4%

: 70-55-3
toluene-4-sulfonamide

: 637-64-9
tetrahydrofurfuryl acetate

A: C14H19NO5S

B: C14H19NO5S

Conditions

Conditions	Yield
With [bis(acetoxy)iodo]benzene; copper(II) bis(trifluoromethanesulfonate) In dichloromethane at 40℃; for 4h;	A 40% B 30%

...Expand

: 67-56-1
methanol

: 637-64-9
tetrahydrofurfuryl acetate

A: 14152-75-1, 26528-66-5
Methyl-5-O-acetyl-2,3-dideoxy-pentofuranosid

B: 6922-39-0
succinaldehyde bis(dimethyl acetal)

C: 112570-93-1
Acetic acid 2-methoxy-tetrahydro-furan-2-ylmethyl ester

Conditions

Conditions	Yield
for 5.4h; electrolysis: platinum-plate anode, carbon-rod cathode, Et4NOTs, 50 F/mol, 0.5 A, 20 V;	A 18% B 23% C 5%

...Expand

: 58-08-2
3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione

: 637-64-9
tetrahydrofurfuryl acetate

: 51015-47-5
8-(5-acetoxymethyl-tetrahydro-furan-2-yl)-1,3,7-trimethyl-3,7-dihydro-purine-2,6-dione

Conditions

Conditions	Yield
With di-tert-butyl peroxide In water for 24h; Irradiation;

: 58-08-2
3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione

: 637-64-9
tetrahydrofurfuryl acetate

: 51015-48-6
8-(2-acetoxymethyl-tetrahydro-furan-2-yl)-1,3,7-trimethyl-3,7-dihydro-purine-2,6-dione

Conditions

Conditions	Yield
With di-tert-butyl peroxide In water for 24h; Irradiation;

: 506-96-7
Acetyl bromide

: 637-64-9
tetrahydrofurfuryl acetate

: 81947-72-0, 155667-35-9, 155667-36-0
1,2-diacetoxypentane

Conditions

Conditions	Yield
(i) ZnCl2, (ii) LiAlH4, iPr2O, (iii) Ac2O; Multistep reaction;

: 109-89-7
diethylamine

: 75-36-5
acetyl chloride

: 637-64-9
tetrahydrofurfuryl acetate

: 20473-83-0
1,2-diacetoxy-5-diethylamino-pentane

Conditions

Conditions	Yield
(i), (ii) /BRN= 605268/; Multistep reaction;

...Expand

Tetrahydrofurfuryl acetate Specification

The 2-Furanmethanol,tetrahydro-, 2-acetate, with the CAS registry number 637-64-9, is also known as 2-(Acetoxymethyl)tetrahydrofuran. It belongs to the product category of Ester Flavor. Its EINECS registry number is 211-296-8. This chemical's molecular formula is C₇H₁₂O₃ and molecular weight is 144.16838. Its IUPAC name is called oxolan-2-ylmethyl acetate. The product should be sealed and stored in cool and dry place. What's more, it should be protected from strong oxides.

Physical properties of 2-Furanmethanol,tetrahydro-, 2-acetate: (1)ACD/LogP: 0.16; (2)ACD/LogD (pH 5.5): 0.16; (3)ACD/LogD (pH 7.4): 0.16; (4)#H bond acceptors: 3; (5)#Freely Rotating Bonds: 3; (6)Index of Refraction: 1.434; (7)Molar Refractivity: 35.78 cm³; (8)Molar Volume: 137.3 cm³; (9)Surface Tension: 34.7 dyne/cm; (10)Density: 1.049 g/cm³; (11)Flash Point: 84.4 °C; (12)Enthalpy of Vaporization: 44.17 kJ/mol; (13)Boiling Point: 205.5 °C at 760 mmHg; (14)Vapour Pressure: 0.249 mmHg at 25°C.

Preparation: this chemical can be prepared by Tetrahydrofurfuryl alcohol and acetic anhydride. This reaction will need inorganic acid.

Uses of 2-Furanmethanol,tetrahydro-, 2-acetate: it can be used to produce Essigsaeure-2,5-dibrom-pentyl-ester by heating. This reaction will need reagent bromotrimethylsilane with reaction time of 48 hours. The yield is about 87%.

You can still convert the following datas into molecular structure:
(1)Canonical SMILES: CC(=O)OCC1CCCO1
(2)InChI: InChI=1S/C7H12O3/c1-6(8)10-5-7-3-2-4-9-7/h7H,2-5H2,1H3
(3)InChIKey: AAQDYYFAFXGBFZ-UHFFFAOYSA-N

Product Name

TETRAHYDROFURFURYL ACETATE

Synthetic route

Tetrahydrofurfuryl acetate Specification

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