Tetrahydrofurfuryl alcohol supplier

Name
Tetrahydrofurfuryl alcohol
EINECS 202-625-6
CAS No. 97-99-4
Article Data282
CAS DataBase
Density 1.039 g/cm³
Solubility soluble in water
Melting Point -80 °C
Formula C₅H₁₀O₂
Boiling Point 176.818 °C at 760 mmHg
Molecular Weight 102.133
Flash Point 83.889 °C
Transport Information
Appearance Colorless to light yellow liquid
Safety 39
Risk Codes 36
Molecular Structure
Hazard Symbols Xi
Synonyms Furfurylalcohol, tetrahydro- (8CI);(Tetrahydrofuran-2-yl)methanol;2-(Hydroxymethyl)tetrahydrofuran;NSC 15434;QO THFA;Rac-(Tetrahydrofuran-2-yl)methanol;THFA;Tetrahydro-2-furancarbinol;Tetrahydro-2-furanylmethanol;Tetrahydrofurfuryl alcohol;
PSA 29.46000
LogP 0.15770

Synthetic route

: 98-01-1
furfural

: 97-99-4
Tetrahydrofurfuryl alcohol

Conditions

Conditions	Yield
With hydrogen In ethanol at 60℃; under 15001.5 Torr; for 4h; Catalytic behavior; Reagent/catalyst; Temperature; Solvent; Pressure; Autoclave; Green chemistry;	100%
With hydrogen In butan-1-ol at 80℃; under 30003 Torr; for 5h; Catalytic behavior; Temperature; Reagent/catalyst;	99%
With hydrogen In isopropyl alcohol at 179.84℃; under 22502.3 Torr; for 1.25h; Reagent/catalyst;	99%

: 98-00-0
(2-furyl)methyl alcohol

: 97-99-4
Tetrahydrofurfuryl alcohol

Conditions

Conditions	Yield
With 3% Pd/C; hydrogen In isopropyl alcohol at 219.84℃; under 25858.1 Torr; for 5h; Inert atmosphere;	100%
With hydrogen In isopropyl alcohol at 25℃; under 7500.75 Torr; for 3h; Green chemistry;	100%
With palladium on activated charcoal; ammonia; hydrogen In tetrahydrofuran at 160℃; for 4h; Reagent/catalyst; Autoclave;	100%

: 21915-56-0
5-hydroxy-1,2-epoxypentane

: 97-99-4
Tetrahydrofurfuryl alcohol

Conditions

Conditions	Yield
With Hexafluorobenzene at 20℃; for 22h;	100%
With C10H12NO(1+)*BF4(1-) In dichloromethane
With hydrogenchloride In water; tert-butyl alcohol at 20℃; for 2h; Green chemistry;
With Hexafluorobenzene In dichloromethane-d2 at 20℃; Kinetics; Reagent/catalyst; Solvent;

: 821-09-0
n-Pent-4-enyl alcohol

: 97-99-4
Tetrahydrofurfuryl alcohol

Conditions

Conditions	Yield
With pyridine-3-carbonitrile; dihydrogen peroxide; methyltrioxorhenium(VII) In dichloromethane at 24℃; for 18h;	97%
With C10H12NO(1+)*BF4(1-) In dichloromethane for 3.5h; Ambient temperature;	95%
With molecular sieve; dihydrogen peroxide In water at 59.85℃; for 3h;	99 % Chromat.

: 637-64-9
tetrahydrofurfuryl acetate

: 97-99-4
Tetrahydrofurfuryl alcohol

Conditions

Conditions	Yield
With ytterbium(III) triflate In isopropyl alcohol for 8h; Deacetylation; Heating;	95%
With MetProLeuAspGlnProThrAlaAlaPheLeuAspPheLeuArgSerSerGlyGlyLysProLeuTyrGluLeuProLeuAlaGluAlaArgAlaAlaMetAlaMetGlySerGlnLeuGlyAlaProProAlaAspValGlyArgIleValAspArgSerIleAspValProGlyGlyAlaValAlaLeuArgIleTyrThrProAlaThrThrLysAlaGlyGlyLeuLeuProAlaIleLeuGlnTyrHisGlyGlyGlyPheValLeuGlyAsnLeuAspThrHisGluSerIleAlaArgPheTyrCysAlaHisAlaGlyAlaValValIleSerValAspTyrArgLeuAlaProGluHisArgPheProThrGlnValGluAspSerPheAlaAlaLeuThrTrpValSerGluHisAlaSerGluLeuGlyValAspProAlaArgValAlaValAlaGlyAspSerAlaGlyGlyAsnLeuAlaThrValMetCysLeuLeuAlaLysAlaArgGlyGlyProArgIleAlaCysGlnAlaLeuLeuTyrProValAlaAspPheArgProGluGlnValTyrAlaSerHisAlaGlnPheGlyAspGlySerTyrPheLeuSerSerLysAspMetAspTrpPheArgAlaSerTyrPheThrAspValAlaSerGlnAlaAlaGluProThrAlaSerProMetAlaThrThrAspLeuSerGlyLeuProProAlaLeuValThrThrAlaGlyCysAspProLeuLeuAspGluGlyArgAlaTyrAlaAspArgLeuLysAlaAlaGlyValProValAspTyrArgCysPheGluThrThrIleHisAlaCysAlaSerPheAlaGlyThrIleProAlaGlyLeuAspMetLeuGlyPheValAlaAspTrpLeuAlaAlaHisThrLys In aq. phosphate buffer at 37℃; pH=7.5; Reagent/catalyst; Enzymatic reaction; enantioselective reaction;

Yield

With ytterbium(III) triflate In isopropyl alcohol for 8h; Deacetylation; Heating;

95%

With MetProLeuAspGlnProThrAlaAlaPheLeuAspPheLeuArgSerSerGlyGlyLysProLeuTyrGluLeuProLeuAlaGluAlaArgAlaAlaMetAlaMetGlySerGlnLeuGlyAlaProProAlaAspValGlyArgIleValAspArgSerIleAspValProGlyGlyAlaValAlaLeuArgIleTyrThrProAlaThrThrLysAlaGlyGlyLeuLeuProAlaIleLeuGlnTyrHisGlyGlyGlyPheValLeuGlyAsnLeuAspThrHisGluSerIleAlaArgPheTyrCysAlaHisAlaGlyAlaValValIleSerValAspTyrArgLeuAlaProGluHisArgPheProThrGlnValGluAspSerPheAlaAlaLeuThrTrpValSerGluHisAlaSerGluLeuGlyValAspProAlaArgValAlaValAlaGlyAspSerAlaGlyGlyAsnLeuAlaThrValMetCysLeuLeuAlaLysAlaArgGlyGlyProArgIleAlaCysGlnAlaLeuLeuTyrProValAlaAspPheArgProGluGlnValTyrAlaSerHisAlaGlnPheGlyAspGlySerTyrPheLeuSerSerLysAspMetAspTrpPheArgAlaSerTyrPheThrAspValAlaSerGlnAlaAlaGluProThrAlaSerProMetAlaThrThrAspLeuSerGlyLeuProProAlaLeuValThrThrAlaGlyCysAspProLeuLeuAspGluGlyArgAlaTyrAlaAspArgLeuLysAlaAlaGlyValProValAspTyrArgCysPheGluThrThrIleHisAlaCysAlaSerPheAlaGlyThrIleProAlaGlyLeuAspMetLeuGlyPheValAlaAspTrpLeuAlaAlaHisThrLys In aq. phosphate buffer at 37℃; pH=7.5; Reagent/catalyst; Enzymatic reaction; enantioselective reaction;

: 710-14-5
tetrahydrofurfuryl tetrahydropyranyl ether

: 97-99-4
Tetrahydrofurfuryl alcohol

Conditions

Conditions	Yield
With methanol; zirconium(IV) chloride at 20℃; for 7h;	93%

: 98-01-1
furfural

A: 97-99-4
Tetrahydrofurfuryl alcohol

B: 7681-84-7
tetrahydrofuran-2-carbaldehyde

Conditions

Conditions	Yield
With 5%-palladium/activated carbon; hydrogen In water at 2℃; under 60006 Torr; for 2h; Reagent/catalyst; Autoclave;	A 91.9% B n/a
With hydrogen In water at 1.84℃; under 60006 Torr; for 4h; Catalytic behavior; Autoclave;
With palladium on activated charcoal; hydrogen In toluene at 170℃; under 52505.3 Torr; for 1h; Solvent; Autoclave;	A 52.2%Chromat. B 7.6%Chromat.

: 98-01-1
furfural

A: 97-99-4
Tetrahydrofurfuryl alcohol

B: 4795-29-3
TETRAHYDROFURFURYLAMINE

Conditions

Conditions	Yield
With ammonia; hydrogen In tetrahydrofuran at 180℃; for 12h; Autoclave;	A 5.1% B 91%
Multi-step reaction with 2 steps 1: ammonia; hydrogen / tetrahydrofuran / 2 h / 80 °C / Autoclave 2: ammonia; hydrogen / tetrahydrofuran / 24 h / 160 °C / Autoclave View Scheme

: 98-01-1
furfural

A: 97-99-4
Tetrahydrofurfuryl alcohol

B: 98-00-0
(2-furyl)methyl alcohol

Conditions

Conditions	Yield
With hydrogen at 90℃; under 15001.5 Torr; Reagent/catalyst;	A 90.5% B 8.4%
With hydrogen In butan-1-ol at 40℃; under 30003 Torr; for 7h; Catalytic behavior; Reagent/catalyst;	A 12% B 85%
With hydrogen In tetrahydrofuran at 175℃; under 7500.75 Torr; for 8h; Catalytic behavior; Pressure; Temperature; Time; chemoselective reaction;	A 10% B 79.5%

: 98-01-1
furfural

A: 97-99-4
Tetrahydrofurfuryl alcohol

B: 626-95-9
1,4-Pentanediol

Conditions

Conditions	Yield
With carbon dioxide; hydrogen In water at 80℃; under 30003 Torr; for 20h; Catalytic behavior; Reagent/catalyst; Pressure; Temperature; Autoclave;	A 9% B 90%
With hydrogen In water at 140℃; under 11251.1 Torr; for 4h; Kinetics; Temperature; Autoclave;	A 7% B 87%

: 69406-23-1
2-(((4-methoxybenzyl)oxy)methyl)tetrahydrofuran

: 97-99-4
Tetrahydrofurfuryl alcohol

Conditions

Conditions	Yield
With 4,4'-bipyridine; (phthalocyaninato)iron(II); oxygen; 2,3-dicyano-5,6-dichloro-p-benzoquinone In toluene at 80℃; under 3000.3 Torr; for 24h; Autoclave;	86%
With 4,4'-bipyridine; oxygen; 2,3-dicyano-5,6-dichloro-p-benzoquinone In toluene at 120℃; under 3750.38 Torr; for 7h; Autoclave; Green chemistry;	65%
With ammonium peroxydisulfate; 9-(2-mesityl)-10-methylacridinium perchlorate In dichloromethane; water at 20 - 30℃; for 3.5h; Irradiation; Green chemistry;	65%
With tert.-butylnitrite; oxygen; 2,3-dicyano-5,6-dichloro-p-benzoquinone In monoethylene glycol diethyl ether at 120℃; under 1500.15 Torr; for 1.5h;
With tert.-butylnitrite; oxygen; 2,3-dicyano-5,6-dichloro-p-benzoquinone In chlorobenzene at 100℃; under 760.051 Torr; for 1h;

: 98-00-0
(2-furyl)methyl alcohol

A: 97-99-4
Tetrahydrofurfuryl alcohol

B: 534-22-5
2-methylfuran

Conditions

Conditions	Yield
With hydrogen at 250℃; under 760.051 Torr;	A 6.2% B 83.3%
With hydrogen In methanol at 25℃; under 750.075 Torr; for 1h; Reagent/catalyst; Sealed tube; Green chemistry;	A 69.4% B 14.3%
With hydrogen In ethanol at 25℃; for 1h; Sealed tube; Green chemistry;	A 43% B 50%

: 16874-33-2
tetrahydro-2-furancarboxylic acid

: 97-99-4
Tetrahydrofurfuryl alcohol

Conditions

Conditions	Yield
With hydrogen In neat (no solvent) at 160℃; under 37503.8 Torr; for 24h;	83%
Stage #1: tetrahydro-2-furancarboxylic acid With lithium aluminium tetrahydride In tetrahydrofuran; diethyl ether at -20 - 20℃; Stage #2: With water In tetrahydrofuran; diethyl ether; ethyl acetate at 0 - 20℃;
With tin(II) trifluoromethanesulfonate; tris(2,4-pentanedionato)ruthenium(III); hydrogen; [2-((diphenylphospino)methyl)-2-methyl-1,3-propanediyl]bis[diphenylphosphine] In water; toluene at 160℃; under 45004.5 Torr; for 24h; Autoclave;	80 %Chromat.

: 534-22-5
2-methylfuran

A: 96-47-9
2-methyltetrahydrofuran

B: 97-99-4
Tetrahydrofurfuryl alcohol

Conditions

Conditions	Yield
With carbon dioxide; 5% Pd(II)/C(eggshell); hydrogen at 300℃; under 112511 Torr; Supercritical conditions;	A 82% B 6%

: 126680-80-6
tert-butyldimethyl((tetrahydrofuran-2-yl)methoxy)silane

: 97-99-4
Tetrahydrofurfuryl alcohol

Conditions

Conditions	Yield
With zinc tetrafluoroborate In water for 5h; Ambient temperature;	80%
With Nafion-H(R); sodium iodide In methanol at 20℃; for 7h;

: 98-00-0
(2-furyl)methyl alcohol

A: 97-99-4
Tetrahydrofurfuryl alcohol

B: 5343-92-0
1,2-pentanediol

Conditions

Conditions	Yield
With 5%PtO2-Al2O3; hydrogen In ethanol at 0 - 5℃; under 750.075 Torr; for 5h;	A 15% B 80%
With hydrogen; 5 % platinum dioxide on gamma-aluminum oxide In ethanol at 0 - 5℃; under 750.075 Torr; for 5h;	A n/a B 80%
With water; hydrogen at 120℃; under 22502.3 Torr; for 4h; chemoselective reaction;

: 98-01-1
furfural

A: 97-99-4
Tetrahydrofurfuryl alcohol

B: 96-41-3
Cyclopentanol

C: 120-92-3
cyclopentanone

Conditions

Conditions	Yield
With hydrogen In water at 160℃; under 30003 Torr; for 2.5h; Reagent/catalyst; Autoclave;	A n/a B n/a C 79%
With hydrogen In water at 175℃; under 60006 Torr; for 0.5h;	A 9.7 mol B n/a C n/a
With 20% Ni/Co3O4; hydrogen In water at 149.84℃; under 30003 Torr; for 6h; Reagent/catalyst; Autoclave; chemoselective reaction;

...Expand

: 98-01-1
furfural

A: 96-47-9
2-methyltetrahydrofuran

B: 97-99-4
Tetrahydrofurfuryl alcohol

Conditions

Conditions	Yield
Stage #1: furfural With hydrogen at 160℃; under 760.051 Torr; Flow reactor; Stage #2: With hydrogen at 130℃; under 760.051 Torr; Flow reactor;	A 13.7% B 78.2%
With hydrogen In 1,4-dioxane; isopropyl alcohol at 200℃; under 48754.9 Torr; for 6h; Reagent/catalyst;	A 36% B 45%
Multi-step reaction with 2 steps 1: isopropyl alcohol; 10% Pd/C / 7.5 h / 150 °C / Inert atmosphere 2: isopropyl alcohol; 10% Pd/C / 7.5 h / 180 °C / Inert atmosphere View Scheme

: 98-01-1
furfural

A: 97-99-4
Tetrahydrofurfuryl alcohol

B: 110-00-9
furan

C: 534-22-5
2-methylfuran

D: 98-00-0
(2-furyl)methyl alcohol

Conditions

Conditions	Yield
With hydrogen In methanol at 119.84℃; under 7500.75 Torr; for 1h; Catalytic behavior; Solvent; Reagent/catalyst; Autoclave;	A 6.2% B 8.9% C 7.7% D 75.5%
With hydrogen In isopropyl alcohol at 180℃; under 15001.5 Torr; for 5h; Kinetics; Catalytic behavior; Time; Autoclave; Sealed tube;	A 13% B 22% C 54% D 8%
With hydrogen at 250℃; under 760.051 Torr;	A 10.2% B 13.5% C 38.6% D 19%

...Expand

: 98-01-1
furfural

A: 97-99-4
Tetrahydrofurfuryl alcohol

B: 534-22-5
2-methylfuran

C: 98-00-0
(2-furyl)methyl alcohol

Conditions

Conditions	Yield
With hydrogen In isopropyl alcohol at 229.84℃; under 30003 Torr; for 5h;	A 18% B 14% C 71%
With hydrogen In isopropyl alcohol at 229.84℃; under 30003 Torr; for 2h;	A 7.2% B 61% C 8%
With hydrogen at 30℃; Kinetics;

...Expand

: 98-01-1
furfural

A: 96-47-9
2-methyltetrahydrofuran

B: 97-99-4
Tetrahydrofurfuryl alcohol

C: 98-00-0
(2-furyl)methyl alcohol

Conditions

Conditions	Yield
Stage #1: furfural With hydrogen at 160℃; under 760.051 Torr; Flow reactor; Stage #2: With hydrogen at 120℃; under 760.051 Torr; Flow reactor;	A 13.1% B 70% C 9.1%
With Ni3Sn2; hydrogen In isopropyl alcohol at 20 - 179.84℃; for 12h; Autoclave;	A 5 %Chromat. B 5 %Chromat. C 91 %Chromat.
With hydrogen In isopropyl alcohol at 50℃; under 3750.38 Torr; Autoclave;

...Expand

: 98-01-1
furfural

A: 97-99-4
Tetrahydrofurfuryl alcohol

B: 111-29-5
1 ,5-pentanediol

C: 6032-29-7
(+/-)-2-pentanol

D: 71-41-0
pentan-1-ol

Conditions

Conditions	Yield
With hydrogen In isopropyl alcohol at 150℃; under 30003 Torr; for 8h; Temperature; Pressure; Autoclave;	A 68.7% B 24.2% C n/a D n/a

...Expand

: 1708-29-8
2,5-dihydrofuran

: 201230-82-2
carbon monoxide

A: 97-99-4
Tetrahydrofurfuryl alcohol

B: 124391-75-9, 124506-31-6, 15833-61-1
3-tetrahydrofuranmethanol

Conditions

Conditions	Yield
With [bis(2-methylallyl)cycloocta-1,5-diene]ruthenium(II); 2-(dicyclohexylphosphanyl)-1-(2-methoxyphenyl)-1H-imidazole; hydrogen In toluene at 160℃; under 37503.8 Torr; for 24h; Autoclave; Inert atmosphere; Overall yield = 60 %Chromat.; regioselective reaction;	A n/a B 66%

...Expand

: 1191-99-7
2,3-dihydro-2H-furan

: 201230-82-2
carbon monoxide

A: 97-99-4
Tetrahydrofurfuryl alcohol

B: 124391-75-9, 124506-31-6, 15833-61-1
3-tetrahydrofuranmethanol

Conditions

Conditions	Yield
With [bis(2-methylallyl)cycloocta-1,5-diene]ruthenium(II); 2-(dicyclohexylphosphanyl)-1-(2-methoxyphenyl)-1H-imidazole; hydrogen In toluene at 160℃; under 37503.8 Torr; for 24h; Autoclave; Inert atmosphere; Overall yield = 60 %Chromat.; regioselective reaction;	A n/a B 66%

...Expand

: 98-00-0
(2-furyl)methyl alcohol

: 67-56-1
methanol

A: 97-99-4
Tetrahydrofurfuryl alcohol

B: 19354-27-9
methyl tetrahydrofurfuryl ether

C: 4799-62-6
O-methyl-pentamethylene glycol

Conditions

Conditions	Yield
With palladium on activated charcoal; hydrogen at 170℃; under 52505.3 Torr; for 2h; Autoclave;	A 64.5% B n/a C n/a

...Expand

: 98-00-0
(2-furyl)methyl alcohol

A: 97-99-4
Tetrahydrofurfuryl alcohol

B: 626-95-9
1,4-Pentanediol

C: 108-29-2
5-methyl-dihydro-furan-2-one

Conditions

Conditions	Yield
With palladium on activated charcoal; water; hydrogen at 170℃; under 52505.3 Torr; for 2h; Autoclave;	A 64% B n/a C n/a

...Expand

: 67-56-1
methanol

: 67-47-0
5-hydroxymethyl-2-furfuraldehyde

A: 97-99-4
Tetrahydrofurfuryl alcohol

B: 19354-27-9
methyl tetrahydrofurfuryl ether

C: 4799-62-6
O-methyl-pentamethylene glycol

Conditions

Conditions	Yield
With palladium on activated charcoal; hydrogen at 170℃; under 52505.3 Torr; for 2h; Autoclave;	A 63.4% B n/a C n/a

...Expand

: 98-01-1
furfural

A: 97-99-4
Tetrahydrofurfuryl alcohol

B: 626-95-9
1,4-Pentanediol

C: 1071-73-4
5-Hydroxy-2-pentanone

Conditions

Conditions	Yield
With hydrogen; toluene-4-sulfonic acid In water at 140℃; under 11251.1 Torr; for 4h; Autoclave;	A 19% B 63% C 8%
With carbon dioxide; hydrogen In water at 80℃; under 30003 Torr; for 20h; Catalytic behavior; Reagent/catalyst; Temperature; Autoclave;	A 8% B 57% C 15%

...Expand

: 98-01-1
furfural

A: 97-99-4
Tetrahydrofurfuryl alcohol

B: 98-00-0
(2-furyl)methyl alcohol

C: 1453-62-9
2-furaldehyde dimethyl acetal

Conditions

Conditions	Yield
With hydrogen In methanol at 100℃; under 15001.5 Torr; Catalytic behavior; Reagent/catalyst; Autoclave;	A n/a B 60% C n/a

...Expand

: 98-01-1
furfural

A: 97-99-4
Tetrahydrofurfuryl alcohol

B: 110-00-9
furan

C: 98-00-0
(2-furyl)methyl alcohol

Conditions

Conditions	Yield
With MnO2#dotPd; hydrogen In isopropyl alcohol at 180℃; under 15001.5 Torr; for 5h; Kinetics; Catalytic behavior; Time; Autoclave; Sealed tube;	A 8.3% B 14.11% C 59.76%
With hydrogen In isopropyl alcohol at 120℃; under 45004.5 Torr; for 3h; Reagent/catalyst;
With Ni-doped silica; hydrogen at 140℃; under 760.051 Torr; for 2h; Flow reactor;

...Expand

: 97-99-4
Tetrahydrofurfuryl alcohol

: 98-59-9
p-toluenesulfonyl chloride

: 34583-63-6
rac-(tetrahydrofuran-2-yl)methyl 4-methylbenzenesulfonate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0℃; for 1h;	100%
With potassium hydroxide	93%
With potassium iodide; silver(l) oxide In dichloromethane at 40℃;	91%

: 97-99-4
Tetrahydrofurfuryl alcohol

: 449813-82-5
3-(diphenylphosphono)-2-(N-cyanoimino)thiazolidine

: 33026-82-3
<(tetrahydrofurfuryl)oxy>diphenyphosphine

Conditions

Conditions	Yield
With tert-butylmagnesium chloride In tetrahydrofuran at 20℃; for 0.5h; Product distribution; Further Variations:; Reagents; reaction times;	100%

: 97-99-4
Tetrahydrofurfuryl alcohol

: 625-38-7
but-3-enoic acid

: 1198472-55-7
tetrahydrofurfuryl vinylacetate

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0 - 20℃; Inert atmosphere;	100%

: 97-99-4
Tetrahydrofurfuryl alcohol

: 546-68-9
titanium(IV) isopropylate

: 1346523-06-5
C16H32O6Ti

Conditions

Conditions	Yield
In cyclohexane Inert atmosphere; Reflux;	100%
In cyclohexane for 0.5h; Schlenk technique; Inert atmosphere; Reflux;	100%

: 97-99-4
Tetrahydrofurfuryl alcohol

: 110-87-2
3,4-dihydro-2H-pyran

: 710-14-5
tetrahydrofurfuryl tetrahydropyranyl ether

Conditions

Conditions	Yield
With zirconium(IV) chloride In dichloromethane for 3h;	99%
With Envirocat EPZG at 0 - 5℃; for 1h;	98%
With 1-butyl-3-methylimidazolium hydrogen sulfate at 20℃; for 0.166667h;	98%

: 97-99-4
Tetrahydrofurfuryl alcohol

: 108-24-7
acetic anhydride

: 637-64-9
tetrahydrofurfuryl acetate

Conditions

Conditions	Yield
With phosphoric acid In acetonitrile at 50℃; for 3h;	99%
With zirconium sulfophenyl phosphonate In dichloromethane at 20℃; for 3h; Acetylation;	97%
With aluminum triflate at 20℃; for 0.00555556h;	96%

: 97-99-4
Tetrahydrofurfuryl alcohol

: 105-58-8
Diethyl carbonate

: 108106-20-3
carbonate d'ethyle et de (2-tetrahydrofuryl) methyle

Conditions

Conditions	Yield
aluminum oxide; cesium fluoride at 129.85℃; for 0.5h;	99%
With MgLa mixed oxide at 125℃; for 4h;	99%
tiveTMNanoMgOPlus(NAP-MgO,Aerogel*prepared) at 125℃; for 3h;	99%
With immobilized 1,5,7-triazabicyclo[4.4.0]dec-5-ene on magnetic γ-Fe2O3 nanoparticles at 125℃; for 10h;	93%

: 97-99-4
Tetrahydrofurfuryl alcohol

: 15933-59-2
1,1,3,3-tetramethyldisilazane

: 1333319-95-1
1,1,3,3-tetramethyl-1,3-bis[(tetrahydrofuran-2-yl)methoxy]disiloxane

Conditions

Conditions	Yield
With 1.2% Pd/C at 20℃; for 20h; Inert atmosphere;	99%

: 97-99-4
Tetrahydrofurfuryl alcohol

: uranyl nirate hexahydrate

: C13H26N2O10U

Conditions

Conditions	Yield
In chloroform at 20℃; for 0.166667h;	99%

: 97-99-4
Tetrahydrofurfuryl alcohol

: 959958-25-9
5-bromo-6-chloropyridine-2-carboxylic acid

: 1415899-56-7
5-bromo-6-(tetrahydrofuran-2-ylmethoxy)pyridine-2-carboxylic acid

Conditions

Conditions	Yield
Stage #1: 5-bromo-6-chloropyridine-2-carboxylic acid With potassium hydroxide In dimethyl sulfoxide at 20℃; for 0.25h; Stage #2: Tetrahydrofurfuryl alcohol In dimethyl sulfoxide at 20℃; for 24h;	99%
Stage #1: 5-bromo-6-chloropyridine-2-carboxylic acid With potassium hydroxide In dimethyl sulfoxide at 20℃; for 0.25h; Stage #2: Tetrahydrofurfuryl alcohol In dimethyl sulfoxide at 20℃; for 24h; Stage #3: With hydrogenchloride In water	99%
Stage #1: 5-bromo-6-chloropyridine-2-carboxylic acid With potassium hydroxide In dimethyl sulfoxide at 20℃; for 0.25h; Stage #2: Tetrahydrofurfuryl alcohol In dimethyl sulfoxide at 20℃; for 24h;	99%

: 97-99-4
Tetrahydrofurfuryl alcohol

: 76578-14-8
(R)-2-[4-[(6-chloro-2-quinoxalinyl)oxy]phenoxy]propanoic acid ethyl ester

: 200509-41-7
(RS)-tetrahydrofuran-2-ylmethyl (R)-2-[4-(6-chloro-2-quinoxalinyloxy)phenoxy]propionate

Conditions

Conditions	Yield
Stage #1: Tetrahydrofurfuryl alcohol; (R)-2-[4-[(6-chloro-2-quinoxalinyl)oxy]phenoxy]propanoic acid ethyl ester In toluene at 115℃; for 2h; Stage #2: With tetraisopropanoyl titanate In toluene at 80 - 130℃; for 4h;	98.6%
With di(n-butyl)tin oxide at 75 - 130℃; for 8h; Temperature; Concentration;	98%

: 97-99-4
Tetrahydrofurfuryl alcohol

: 124-63-0
methanesulfonyl chloride

: 72641-13-5
tetrahydro-2-furanmethanol methanesulfonate (ester)

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 36h;	98%
With triethylamine In dichloromethane at 0℃; for 14h;	92%
With pyridine at 20℃; for 60h; Inert atmosphere; Cooling with ice;	77%

: 97-99-4
Tetrahydrofurfuryl alcohol

: 16090-09-8, 17229-80-0, 29126-50-9
lithium succinate

: (tetrahydrofuran-2-ylmethoxy)butanedioic acid

Conditions

Conditions	Yield
With lanthanum(III) chloride at 140℃; for 7.7h;	97%

: 97-99-4
Tetrahydrofurfuryl alcohol

: neodymium chloride tris(isopropanol)

: neodymium chloride tris(tetrahydrofurfuryl alcohol)

Conditions

Conditions	Yield
In benzene addn. of lanthanide-compd. to anhyd. benzene containing ligand, refluxing for 4 h under exclusion of moisture; removal of isopropanol by azeotropical distn., removal of benzene, filtn., washing with dry benzene, drying for 4 h under reduced pressure, elem. anal.;	97%

: 97-99-4
Tetrahydrofurfuryl alcohol

: 7550-45-0
titanium tetrachloride

A: 7647-01-0
hydrogenchloride

B: titanium(IV) trichloride(tetrahydrofuran-2-methanolate)

Conditions

Conditions	Yield
In hexane N2-atmosphere; alcohol dropvise addn. with stirring (pptn.); washing (n-hexane), drying (vac.); elem. anal.;	A n/a B 97%

...Expand

: 97-99-4
Tetrahydrofurfuryl alcohol

: uranyl nirate hexahydrate

: [UO2(κ2-nitrate)2(tetrahydrofurfuryl alcohol)]*H2O

Conditions

Conditions	Yield
In chloroform at 20℃; for 48h;	97%

: 97-99-4
Tetrahydrofurfuryl alcohol

: 98-88-4
benzoyl chloride

: 2217-32-5
(tetrahydrofuran-2-yl)methyl benzoate

Conditions

Conditions	Yield
With iron In 1,2-dichloro-ethane at 84℃; for 3h; Schlenk technique; Inert atmosphere; regioselective reaction;	97%

: 97-99-4
Tetrahydrofurfuryl alcohol

: 201230-82-2
carbon monoxide

: 75-65-0
tert-butyl alcohol

: (tetrahydrofuran-2-yl)methyl 3-methylbutanoate

Conditions

Conditions	Yield
With tris(dibenzylideneacetone)dipalladium(0) chloroform complex; α,α′-bis(2-pyridyl(tert-butyl)phosphino)-o-xylene; toluene-4-sulfonic acid at 120℃; under 15001.5 Torr; for 20h; Autoclave; Inert atmosphere;	97%

...Expand

: 97-99-4
Tetrahydrofurfuryl alcohol

: 999-97-3
1,1,1,3,3,3-hexamethyl-disilazane

: 3067-36-5
trimethyl(tetrahydro-2-furylmethoxy)silane

Conditions

Conditions	Yield
With aluminum tris(dihydrogen phosphate) at 20℃; for 0.2h;	96%
With zinc(II) oxide at 20℃; for 1.83333h;	95%
With Al2O3*HClO4 In acetonitrile at 20℃; for 0.116667h;	93%

: 97-99-4
Tetrahydrofurfuryl alcohol

: 37517-81-0
3-chloro-3-oxopropanoic acid methyl ester

: 1198472-57-9
methyl tetrahydrofurfuryl malonate

Conditions

Conditions	Yield
With pyridine In dichloromethane at 0℃; for 1.5h; Inert atmosphere;	96%

: 97-99-4
Tetrahydrofurfuryl alcohol

: 1798-09-0
m-methoxyphenylacetic acid

: 1198472-48-8
tetrahydrofurfuryl 3-methoxyphenylacetate

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0 - 20℃; Inert atmosphere;	96%

: 97-99-4
Tetrahydrofurfuryl alcohol

: 644-36-0
o-methylphenylacetic acid

: C14H18O3

Conditions

Conditions	Yield
With β-cyclodextrin-SO3H In neat (no solvent) at 70℃; for 3h;	96%

: 97-99-4
Tetrahydrofurfuryl alcohol

: 80-62-6
methacrylic acid methyl ester

: 2455-24-5
(tetrahydrofuran-2-yl)methyl 2-methylprop-2-enoate

Conditions

Conditions	Yield
With 4-acetylamino-2,2,6,6-tetramethyl-1-piperidinoxy; di(n-butyl)tin oxide In 2-Methylpentane; cyclohexane at 85 - 100℃; for 12h; Temperature;	95%
2-methyl-propan-2-ol; lanthanum tri-tert-butylate at 25℃; for 2h;	32 %Chromat.
sodium ethanolate	15 %Chromat.
With sulfuric acid; benzene

: 97-99-4
Tetrahydrofurfuryl alcohol

: 112380-58-2
Carbonic acid benzyl ester 6-trifluoromethyl-benzotriazol-1-yl ester

: 112380-52-6
Carbonic acid benzyl ester furan-2-ylmethyl ester

Conditions

Conditions	Yield
With dmap In tetrahydrofuran at 0℃; for 24h;	95%

: 97-99-4
Tetrahydrofurfuryl alcohol

: 150-90-3
sodium succinate

A: 617-48-1
malic acid

B: (tetrahydrofuran-2-ylmethoxy)butanedioic acid

Conditions

Conditions	Yield
With lanthanum(III) chloride at 116℃; for 19h; Product distribution; also with other alcohols; variation of reaction time, temperature and proportion of reagents;	A 3% B 95%

...Expand

Tetrahydrofurfuryl alcohol Consensus Reports

Tetrahydrofurfuryl alcohol is reported in EPA TSCA Inventory.

Tetrahydrofurfuryl alcohol Specification

1. Introduction of Tetrahydrofurfuryl alcohol

Tetrahydrofurfuryl alcohol, with its CAS No.97-99-4, is is a kind of clear colorless liquid with a mild odorit. It also can be called Furfurylalcohol, tetrahydro- (8CI);(Tetrahydrofuran-2-yl)methanol;2-(Hydroxymethyl)tetrahydrofuran;NSC 15434;QO THFA;Rac-(Tetrahydrofuran-2-yl)methanol;THFA;Tetrahydro-2-furancarbinol and Tetrahydro-2-furanylmethanol. Its flash point 167°F, its vapors are heavier than air, it is denser than water and it is soluble in water . Tetrahydrofurfuryl alcohol (CAS No.97-99-4),inhalation or contact with it may irritate or burn skin and eyes. Fire may produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.

2. Properties of Tetrahydrofurfuryl alcohol

(1) H bond acceptors: 2 (2) H bond donors: 1 (3) Freely Rotating Bonds: 2
(4) Polar Surface Area: 18.46 Å2 (5) Index of Refraction: 1.447 (6) Molar Refractivity: 26.28 cm3
(7) Molar Volume: 98.3 cm3 (8) Surface Tension: 39 dyne/cm (9) Density: 1.038 g/cm3
(10) Flash Point: 83.9 °C (11) Enthalpy of Vaporization: 48.09 kJ/mol (12) Boiling Point: 176.8 °C at 760 mmHg
(13) Vapour Pressure: 0.326 mmHg at 25°C (14) Melting Point: -80 ºC
(15) Refractive Index: 1.451-1.453

3.Strucure descriptors of Tetrahydrofurfuryl alcohol

InChI: InChI=1/C5H10O2/c6-4-5-2-1-3-7-5/h5-6H,1-4H2
InChIKey: BSYVTEYKTMYBMK-UHFFFAOYAA
Std. InChI: InChI=1S/C5H10O2/c6-4-5-2-1-3-7-5/h5-6H,1-4H2
Std. InChIKey: BSYVTEYKTMYBMK-UHFFFAOYSA-N

4. Safety information of Tetrahydrofurfuryl alcohol

Hazard Codes: Irritant
Risk Statements: 36
R36:Irritating to eyes.
Safety Statements: 39
S39:Wear eye / face protection.
WGK Germany: 2
RTECS: LU2450000
HS Code: 29321300
Hazardous Substances Data: 97-99-4(Hazardous Substances Data)

5.Toxicity data of Tetrahydrofurfuryl alcohol

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
guinea pig	LD50	intraperitoneal	400mg/kg (400mg/kg)		"Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 4658, 1982.
guinea pig	LD50	oral	800mg/kg (800mg/kg)		"Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 4658, 1982.
guinea pig	LD50	skin	5gm/kg (5000mg/kg)		"Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 4658, 1982.
mouse	LD50	oral	2300mg/kg (2300mg/kg)	BEHAVIORAL: GENERAL ANESTHETIC	Hygiene and Sanitation Vol. 32(2), Pg. 273, 1967.
rabbit	LD50	intravenous	725mg/kg (725mg/kg)		Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 8, Pg. 294, 1949.
rat	LD50	intraperitoneal	400mg/kg (400mg/kg)		"Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 4658, 1982.
rat	LD50	oral	1600mg/kg (1600mg/kg)		"Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 4658, 1982.

Product Name

Tetrahydrofurfuryl alcohol

Synthetic route

Tetrahydrofurfuryl alcohol Consensus Reports

Tetrahydrofurfuryl alcohol Specification

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