p-Toluidine supplier | CasNO.106-49-0

Name
p-Toluidine
EINECS 203-403-1
CAS No. 106-49-0
Article Data927
CAS DataBase
Density 0.992 g/cm³
Solubility 1.1 g/100 mL in water
Melting Point 43 ºC
Formula C₇H₉N
Boiling Point 197.4 ºC at 760 mmHg
Molecular Weight 107.155
Flash Point 84.5 ºC
Transport Information UN 3451 6.1/PG 2
Appearance white lustrous plates or leaflets with an amine odour
Safety 28-36/37-45-61-28A
Risk Codes 23/24/25-36-40-43-50
Molecular Structure
Hazard Symbols T,N
Synonyms 1-Amino-4-methylbenzene;4-Aminotoluene;4-Methyl-1-aminobenzene;4-Methylaniline;4-Methylbenzenamine;4-Methylphenylamine;4-Toluidine;4-Tolylamine;Benzenamine,4-methyl-;C.I. Azoic Coupling Component 107;Naphthol AS-KG;Naphtol AS-KG;Naphtol AS-KGLL;p-Aminotoluene;p-Methylaniline;p-Methylbenzenamine;p-Methylphenylamine;p-Tolylamine;DHET;Para Toluidine;
PSA 26.02000
LogP 2.15840

Synthetic route

: 99-99-0
1-methyl-4-nitrobenzene

: 106-49-0
p-toluidine

Conditions

Conditions	Yield
With triethylsilane; palladium dichloride In ethanol at 20℃; for 0.5h; Inert atmosphere;	100%
With hydrazine hydrate In ethanol; water at 80℃; for 1h; chemoselective reaction;	100%
With sodium tetrahydroborate In ethanol; water at 39.84℃; for 2h; Reagent/catalyst;	100%

: 619-73-8
4-nitrobenzyl chloride

: 106-49-0
p-toluidine

Conditions

Conditions	Yield
With triethylsilane; palladium dichloride In ethanol at 20℃; for 0.5h; Inert atmosphere;	100%
With hydrogen In ethanol at 80℃; under 2250.23 Torr; for 5h; Catalytic behavior; Inert atmosphere;	95%
With [IrCl(CO)(PPh3)2]; hydrazine hydrate; potassium hydroxide In methanol at 160℃; for 3h; Wolff-Kishner Reduction; Sealed tube;	51%

: 555-16-8
4-nitrobenzaldehdye

: 106-49-0
p-toluidine

Conditions

Conditions	Yield
With triethylsilane; palladium dichloride In ethanol at 20℃; for 0.75h; Inert atmosphere;	100%
With palladium 10% on activated carbon; ammonium formate In ethanol at 100℃; for 24h; Reagent/catalyst;	90%
Stage #1: 4-nitrobenzaldehdye With hydrazine hydrate at 135℃; for 3h; Stage #2: With potassium hydroxide at 135℃; for 24h;	63%
With hydrogen In ethanol; water at 25℃; under 750.075 Torr; for 4h; Schlenk technique;

: 14618-59-8
N-(tert-butoxycarbonyl)-4-methylaniline

: 106-49-0
p-toluidine

Conditions

Conditions	Yield
With water at 100℃; for 10h; Inert atmosphere;	99%
With 3-butyl-l-methyl-1H-imidazol-3-iumtrifloroacetate In 1,4-dioxane; water at 70 - 72℃; for 1h;	98%
With Montmorillonite K10 In dichloromethane for 2h; deacylation; Heating;	97%
With water at 150℃; for 4h; Subcritical conditions;	88%
With zinc(II) iodide In toluene at 120℃; for 24h; Reagent/catalyst; Schlenk technique; Inert atmosphere; Glovebox;

: 2-oxo-2-phenylethyl p-tolylcarbamate

: 106-49-0
p-toluidine

Conditions

Conditions	Yield
With potassium phosphate; tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate; ascorbic acid In water; acetonitrile at 20℃; for 3h; Sealed tube; Irradiation; Inert atmosphere;	99%

: 2101-86-2
p-methylazidobenzene

: 106-49-0
p-toluidine

Conditions

Conditions	Yield
With butyltriphenylphosphonium tetrahydroborate In dichloromethane at 20℃; for 0.266667h;	98%
With iron(III) chloride; sodium iodide In acetonitrile at 20℃; for 0.166667h;	97%
With chloro-trimethyl-silane; sodium iodide In acetonitrile for 0.0833333h; Ambient temperature;	97%

: 106-38-7
para-bromotoluene

: 106-49-0
p-toluidine

Conditions

Conditions	Yield
With copper(I) oxide; ammonium hydroxide In 1-methyl-pyrrolidin-2-one at 80℃; for 15h;	98%
Stage #1: para-bromotoluene With bis(bis(trimethylsilyl)amido)zinc(II); tri-tert-butyl phosphine; lithium chloride; bis(dibenzylideneacetone)-palladium(0) In tetrahydrofuran at 50℃; for 9h; Stage #2: With hydrogenchloride In tetrahydrofuran; diethyl ether	93%
With ammonium hydroxide In neat (no solvent) at 60℃; for 8h;	93%

: 3085-54-9
N-(4-methylphenyl)formamide

: 106-49-0
p-toluidine

Conditions

Conditions	Yield
With water; sodium hydroxide In ethanol at 65 - 70℃; for 1h;	98%
With sodium hydroxide; water In 1,4-dioxane at 70℃; Kinetics; Thermodynamic data; isotope effect (D2O); ΔH(excit.), ΔS(excit.);
With sodium hydroxide In ethanol; water at 40℃; Kinetics;

: 103-89-9
4-Methylacetanilide

: 106-49-0
p-toluidine

Conditions

Conditions	Yield
With 40% potassium fluoride/alumina at 85℃; for 0.0666667h; Microwave irradiation; Neat (no solvent);	98%
With sodium hydroxide In methanol at 80℃;	92%
With pepsin immobilized on terephthalaldehyde functionalized chitosan magnetic nanoparticle In acetonitrile at 20℃; for 48h; pH=2;	83%

: 2318-82-3
N-hydroxy-4-methylbenzamide

: 106-49-0
p-toluidine

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide at 90℃; for 2h; Lossen rearrangement;	98%
With palladium diacetate; triethylamine In acetonitrile at 90℃; for 24h; Solvent; Lossen Rearrangement; Sealed tube;	98%
With potassium carbonate In dimethyl sulfoxide at 90℃; for 2h; Reagent/catalyst; Solvent; Lossen Rearrangement;	98%

: 63534-35-0
3-azidohomoadamantane

: 108-88-3
toluene

A: 76429-91-9
1-(adamantan-1-ylmethyl)-4-methylbenzene

B: 106-49-0
p-toluidine

Conditions

Conditions	Yield
With aluminium trichloride at 80℃; for 1.5h; Yields of byproduct given;	A 97% B n/a

...Expand

: 29540-83-8
p-tolyl triflate

: 106-49-0
p-toluidine

Conditions

Conditions	Yield
Stage #1: p-tolyl triflate With bis(bis(trimethylsilyl)amido)zinc(II); tri-tert-butyl phosphine; tetrabutylammomium bromide; bis(dibenzylideneacetone)-palladium(0) In tetrahydrofuran at 50℃; for 6h; Stage #2: With hydrogenchloride In tetrahydrofuran; diethyl ether	97%
Multi-step reaction with 2 steps 1: Trimethyl borate; water; trifluoroacetic acid; acetone / 15 °C / UV-irradiation; Inert atmosphere 2: sodium hydroxide / methanol / 80 °C View Scheme

: 74552-28-6
N-(p-Tolyl)carbamidsaeure-β-chlorethylester

: 106-49-0
p-toluidine

Conditions

Conditions	Yield
With ammonium chloride; zinc; hydroxycobalamine In ethanol; water at 20℃; for 15h;	96%

: 62-23-7
4-nitro-benzoic acid

: 106-49-0
p-toluidine

Conditions

Conditions	Yield
With sodium tetrahydroborate; titanium tetrachloride In 1,2-dimethoxyethane for 14h; Ambient temperature;	96%

: 31935-68-9
1,1,1-Trimethyl-N-(4-methylphenyl)-N-(trimethylsilyl)silanamine

: 106-49-0
p-toluidine

Conditions

Conditions	Yield
With hydrogenchloride; water In methanol at 20℃; for 1h;	96%
With hydrogenchloride In diethyl ether
With hydrogenchloride In chloroform; water for 1h;	23.6 mg

: 624-31-7
4-tolyl iodide

: 106-49-0
p-toluidine

Conditions

Conditions	Yield
With copper(I) oxide; ammonium hydroxide; C17H14N2O3; potassium hydroxide In ethanol at 60℃; for 24h; Schlenk technique; Inert atmosphere;	96%
With ammonia; triethylamine In water at 20℃; for 3.5h;	96%
With copper(l) iodide; ascorbic acid In ammonia at 25℃; for 18h; Kinetics; liquid NH3;	95%

: 635-46-1
1,2,3,4-tetrahydroisoquinoline

: 99-99-0
1-methyl-4-nitrobenzene

A: 91-22-5
quinoline

B: 106-49-0
p-toluidine

Conditions

Conditions	Yield
With nickel-nitrogen-doped carbon framework In water at 145℃; for 18h; Inert atmosphere; Sealed tube; Green chemistry;	A 94% B 96%

...Expand

: 14674-88-5
2-((p-toluidino)methyl)phenol

A: 106-49-0
p-toluidine

B: C21H18O3

Conditions

Conditions	Yield
at 230℃; under 10 Torr; for 0.0833333h; Product distribution; pyrolysis without solvent;	A 95% B n/a

: 76-05-1
trifluoroacetic acid

: S,S-dimethyl-4-methylanilinosulfonium picrate

A: 350-96-9
2,2,2-trifluoro-N-(4-methylphenyl)acetamide

B: 106-49-0
p-toluidine

C: 67-68-5
dimethyl sulfoxide

Conditions

Conditions	Yield
at 50℃; for 5h; Elimination; acylation; retro-Pummerer reaction;	A 3% B 95% C 67%

...Expand

: 5405-15-2
N-benzyl-N-(4-methylphenyl)amine

: 106-49-0
p-toluidine

Conditions

Conditions	Yield
With ammonium formate; zinc In ethylene glycol for 0.05h; microwave irradiation;	95%

: 2415-85-2
3-oxo-N-(p-tolyl)butanamide

: 95-54-5
1,2-diamino-benzene

A: 615-15-6
2-Methyl-1H-benzimidazole

B: 106-49-0
p-toluidine

Conditions

Conditions	Yield
With 1-n-butyl-3-methylimidazolim bromide In neat (no solvent) at 120℃; for 2h;	A 95% B 90%

...Expand

: 14933-93-8
4'-methylbenzenesulphenanilide

A: 3236-92-8
2,7-dimethylphenazine

B: 106-49-0
p-toluidine

C: 882-33-7
diphenyldisulfane

Conditions

Conditions	Yield
With trifluoroacetic acid In benzene at 25℃;	A 35% B 55% C 94%

...Expand

: 58960-03-5
7-methyl-1,2,3,4-tetrahydroquinoline

: 99-99-0
1-methyl-4-nitrobenzene

A: 612-60-2
7-methylquinoline

B: 106-49-0
p-toluidine

Conditions

Conditions	Yield
With nickel-nitrogen-doped carbon framework In water at 145℃; for 18h; Inert atmosphere; Sealed tube; Green chemistry;	A 92% B 94%

...Expand

: 150-13-0
4-amino-benzoic acid

: 106-49-0
p-toluidine

Conditions

Conditions	Yield
With dimethylsulfide borane complex In chlorobenzene 1) 15 min, r.t. 2) 5 h, reflux;	93%

: 501-60-0, 21650-54-4, 30926-02-4
1,2-di(p-tolyl)diazene

: 106-49-0
p-toluidine

Conditions

Conditions	Yield
With potassium hydroxide; nickel-incorporated hexagonal mesoporous aluminophosphate In isopropyl alcohol at 82.84℃; for 1.5h;	93%
With perchloric acid In isopropyl alcohol; acetonitrile at 25℃; for 0.75h; pH=2; Inert atmosphere; Irradiation;	92%
With ethanol; iron; calcium chloride at 60℃; for 0.5h;	92%

: 5720-05-8
4-methylphenylboronic acid

: 106-49-0
p-toluidine

Conditions

Conditions	Yield
With copper(I) oxide; ammonium hydroxide; air In methanol at 20℃; for 12h;	93%
With sodium hydroxide; hydroxylamine-O-sulfonic acid In acetonitrile at 20℃; for 16h;	90%
With N-Bromosuccinimide; CYANAMID; bis-[(trifluoroacetoxy)iodo]benzene In acetonitrile at 20℃; for 1h; chemoselective reaction;	90%

: 126629-91-2
N-{(Z)-1,3-Diphenyl-3-[(Z)-p-tolylimino]-propenyl}-methanesulfonamide

A: 96355-37-2
3,5-Diphenyl-2H-1,2-thiazin-1,1-dioxid

B: 106-49-0
p-toluidine

Conditions

Conditions	Yield
With lithium diisopropyl amide In tetrahydrofuran at -78 - 25℃; for 12h;	A 92% B n/a

: 126629-93-4
N-{(Z)-3-Phenyl-1-p-tolyl-3-[(Z)-p-tolylimino]-propenyl}-methanesulfonamide

A: 126629-99-0
5-Phenyl-3-p-tolyl-2H-[1,2]thiazine 1,1-dioxide

B: 106-49-0
p-toluidine

Conditions

Conditions	Yield
With lithium diisopropyl amide In tetrahydrofuran at -78 - 25℃; for 12h;	A 92% B n/a

: 106-43-4
para-chlorotoluene

: 106-49-0
p-toluidine

Conditions

Conditions	Yield
With copper(ll) sulfate pentahydrate; ammonium hydroxide In PEG1000-DIL; methyl cyclohexane at 60℃; for 8h;	92%
Stage #1: para-chlorotoluene With bis(bis(trimethylsilyl)amido)zinc(II); tri-tert-butyl phosphine; lithium chloride; bis(dibenzylideneacetone)-palladium(0) In tetrahydrofuran at 90℃; for 12h; Stage #2: With hydrogenchloride In tetrahydrofuran; diethyl ether	90%
With copper(I) oxide; ammonium hydroxide In 1-methyl-pyrrolidin-2-one at 110℃; for 12h; Microwave irradiation;	89%

: 98-01-1
furfural

: 106-49-0
p-toluidine

: 13060-72-5
furfurylidene-p-toluidine

Conditions

Conditions	Yield
In methanol at 20℃; for 24h;	100%
In methanol at 20℃; for 24h;	100%
In methanol at 20℃;	85%

: 85-44-9
phthalic anhydride

: 106-49-0
p-toluidine

: 2142-03-2
2-p-tolylisoindoline-1,3-dione

Conditions

Conditions	Yield
for 1h; Solid phase reaction; condensation;	100%
With 3-butyl-1-methyl-1H-imidazol-3-ium hexafluorophosphate at 80℃; for 8h;	97%
In decaethylene glycol at 120℃; for 3h;	97%

: 108-24-7
acetic anhydride

: 106-49-0
p-toluidine

: 103-89-9
4-Methylacetanilide

Conditions

Conditions	Yield
In dichloromethane at 20℃; Inert atmosphere;	100%
With Methylenediphosphonic acid at 20℃; for 1h; neat (no solvent);	99%
With pyridine; aluminum oxide at 125 - 127℃; for 2h; microwave irradiation;	98%

: 102-92-1
cinnamoyl chloride

: 106-49-0
p-toluidine

: 6876-68-2
N-(4-methylphenyl)-3-phenyl-2-propenamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; Inert atmosphere;	100%
With triethylamine In ethyl acetate at 0 - 20℃;	88%
With potassium hydroxide

: 99-61-6
3-nitro-benzaldehyde

: 106-49-0
p-toluidine

N-(3-nitrobenzylidene)-4-methylbenzenamine: 17064-95-8
N-(3-nitrobenzylidene)-4-methylbenzenamine

Conditions

Conditions	Yield
	100%
With chitosan In ethanol; water at 20℃; for 0.333333h;	85%
With ethanol

: 555-16-8
4-nitrobenzaldehdye

: 106-49-0
p-toluidine

: 730-39-2, 33442-37-4, 149742-47-2
N-(4-nitrobenzylidene)-4-methylaniline

Conditions

Conditions	Yield
for 24h; Ambient temperature;	100%
	100%
With montmorillonite at 20℃; for 0.0666667h; Neat (no solvent);	98%

: 83-72-7
2-Hydroxy-1,4-naphthoquinone

: 106-49-0
p-toluidine

: 57182-49-7
2-(p-toluidino)-1,4-naphthoquinone

Conditions

Conditions	Yield
In neat (no solvent) at 100℃; under 750.075 Torr; for 0.05h; Microwave irradiation;	100%
With acetic acid
With ethanol

: 106-49-0
p-toluidine

: 123-08-0
4-hydroxy-benzaldehyde

: 3230-51-1
p-hydroxybenzal-p-toluidine

Conditions

Conditions	Yield
for 6h; Ambient temperature;	100%
	100%
In ethyl 2-hydroxypropionate at 20℃; for 0.0333333h;	90%

: 106-49-0
p-toluidine

: 126-81-8
dimedone

: 36646-78-3
3-(p-tolylamino)-5,5-dimethylcyclohex-2-enone

Conditions

Conditions	Yield
at 20℃; for 0.5h; Solid phase reaction; condensation;	100%
With fibrous nano silica sulfuric acid In neat (no solvent) at 80℃; for 0.0333333h; Green chemistry;	97%
With silica sulfuric acid In acetonitrile for 0.0194444h; Microwave irradiation;	96%

: 106-49-0
p-toluidine

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 67101-90-0
1,2-dimethoxy-4-<<(4-methylphenyl)imino>methyl>benzene

Conditions

Conditions	Yield
In toluene Heating;	100%

: 106-49-0
p-toluidine

: 98-59-9
p-toluenesulfonyl chloride

: 599-86-0
4-methyl-N-(4-methylphenyl)benzenesulfonamide

Conditions

Conditions	Yield
With pyridine In dichloromethane at 20℃; for 16h;	100%
With pyridine at 0 - 25℃;	100%
In water at 110℃; for 0.0833333h; Microwave irradiation; Green chemistry; chemoselective reaction;	98%

: 106-49-0
p-toluidine

: 625-36-5
2-chloropropionyl chloride

: 19342-88-2
3-chloro-N-(4-methylphenyl)propionamide

Conditions

Conditions	Yield
In acetone for 1h; Acylation; Heating;	100%
In water; acetone for 6h; Reflux;	100%
With potassium carbonate In acetone at 0℃; for 1h; Condensation;	95%

: 106-49-0
p-toluidine

: 552-89-6
2-nitro-benzaldehyde

: 17064-82-3
4-methyl-(2-nitrobenzylidene)aniline

Conditions

Conditions	Yield
	100%
In ethanol for 3h; Reflux;	77.2%
In ethanol for 3h; Reflux;	77.2%

: 106-49-0
p-toluidine

: 111-36-4
n-butyl isocyanide

: 22671-74-5
N-butyl-N’-(4-methylphenyl)urea

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran for 24h; Ambient temperature;	100%
With toluene

: 106-49-0
p-toluidine

: 762-42-5
dimethyl acetylenedicarboxylate

: 24559-80-6
dimethyl (Z)-N-(4-methylphenyl)aminofumarate

Conditions

Conditions	Yield
at 20℃; for 0.133333h; Michael addition;	100%
In benzene at 5 - 10℃;	70%
In diethyl ether

: 108-31-6
maleic anhydride

: 106-49-0
p-toluidine

: 24870-11-9
4-methylmaleanilic acid

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 110℃; for 5h;	100%
In diethyl ether at 20℃; for 2h;	98%
In chloroform for 7h;	97%

: 100-39-0
benzyl bromide

: 106-49-0
p-toluidine

: 5459-79-0
N,N-dibenzyl-4-methylbenzenamine

Conditions

Conditions	Yield
With sodium hydrogencarbonate In N,N,N,N,N,N-hexamethylphosphoric triamide for 0.5h; Heating; 3 equivalents of BzBr;	100%
With montmorillonite-KSF clay supported CuO nanoparticles In neat (no solvent) at 20℃; for 0.75h; Sonication; Green chemistry; chemoselective reaction;	78%
With sodium dodecyl-sulfate; sodium hydrogencarbonate In water at 80℃; for 1h; Inert atmosphere;	71%
With sodium dodecyl-sulfate; sodium hydrogencarbonate In water at 80℃; for 1h;	70%

: 104-88-1
4-chlorobenzaldehyde

: 106-49-0
p-toluidine

: 15485-32-2
N-(4-chlorobenzylidene)-4-toluidine

Conditions

Conditions	Yield
for 6h; Ambient temperature;	100%
In ethyl 2-hydroxypropionate at 20℃; for 0.0333333h;	96%
With montmorillonite at 20℃; for 0.1h; Neat (no solvent);	96%

: 924-44-7
glyoxylic acid ethyl ester

: 106-49-0
p-toluidine

: 121641-60-9
ethyl 2-(4-methylphenylimino)acetate

Conditions

Conditions	Yield
With sodium sulfate In dichloromethane for 0.5h;	100%
With magnesium sulfate In toluene at 25℃; for 0.5h;	100%
for 1h; Green chemistry;	75%

: 40657-29-2
1,1,1-trifluoro-4,4-diethoxy-3-buten-2-one

: 106-49-0
p-toluidine

: 128648-64-6
(E)-4-Ethoxy-1,1,1-trifluoro-4-p-tolylamino-but-3-en-2-one

Conditions

Conditions	Yield
In acetonitrile for 18h; Ambient temperature;	100%

: 128346-30-5
(2-formylphenyl)butyl tellurium dibromide

: 106-49-0
p-toluidine

: 130191-28-5
2-(4'-methylphenyliminomethinyl)phenyltellurenyl bromide

Conditions

Conditions	Yield
With trifluoroacetic acid In benzene	100%

: 94507-26-3
2-<(3-Chloropropyl)amino>-4H-3,1-benzoxazin-4-one

: 106-49-0
p-toluidine

: 94507-35-4
N-(4-Methylphenyl)-2-<3-(3-chloropropyl)ureido>benzamide

Conditions

Conditions	Yield
for 0.05h; Heating;	100%

: 84410-20-8
4-[4a-Methoxy-7-(4-methoxy-3,6-dioxo-cyclohexa-1,4-dienyl)-5,8-dioxo-4-phenyl-4a,5,8,8a-tetrahydro-4H-quinolin-1-yl]-benzoic acid

: 106-49-0
p-toluidine

: 84423-43-8
4-(9-Hydroxy-4a,8-dimethoxy-5,11-dioxo-4-phenyl-6-p-tolyl-4,4a,5,6,11,11a-hexahydro-pyrido[3,2-b]carbazol-1-yl)-benzoic acid

Conditions

Conditions	Yield
With sodium hydrogencarbonate In ethanol; water for 4h; Heating;	100%

: 106-49-0
p-toluidine

: 121-33-5
vanillin

: 53304-12-4
3-methoxy-4-{[(4-methylphenyl)imino]methyl}phenol

Conditions

Conditions	Yield
for 2h; Ambient temperature;	100%
In ethanol for 0.333333h; Reflux;	95.51%
sodium hydrogen sulfate; silica gel at 54 - 56℃; for 0.0236111h; microwave irradiation;	91%

: 106-49-0
p-toluidine

: 15486-96-1
3-Bromopropionyl chloride

: 21437-82-1
3-bomo-N-(4-methylphenyl)propanamide

Conditions

Conditions	Yield
With potassium carbonate In 1,2-dichloro-ethane at 20℃; for 1h; Time; Inert atmosphere;	100%
With dmap In tetrahydrofuran at 0 - 20℃; for 1h;	75%
With triethylamine In benzene	70%

: 98-01-1
furfural

: 106-49-0
p-toluidine

: 4-methyl-N-((tetrahydrofuran-2-yl)methyl)aniline

Conditions

Conditions	Yield
With hydrogen; AV-17-8-Pd In ethanol at 45℃; under 750.06 Torr; Rate constant; Thermodynamic data; E(a);	100%
With hydrogen; AV-17-8-Pd In ethanol at 45℃; under 750.06 Torr;	100%
With Pd/Al2O3; hydrogen In ethanol at 80℃; under 750.075 Torr; for 12h;	94%

: 106-49-0
p-toluidine

: 102-92-1
Cinnamoyl chloride

: 134430-88-9
(2E)-N-(4-methylphenyl)-3-phenylprop-2-enamide

Conditions

Conditions	Yield
With potassium carbonate In water; acetone at 0℃; for 2h;	100%
Stage #1: Cinnamoyl chloride With pyridine; dmap In dichloromethane at 0℃; for 0.416667h; Inert atmosphere; Stage #2: p-toluidine In dichloromethane at 0 - 20℃;	86%
With dmap; sodium hydrogencarbonate In dichloromethane at 20℃;	84%

: 286-20-4
cyclohexane-1,2-epoxide

: 106-49-0
p-toluidine

: trans-2-(p-tolylamino)cyclohexanol

Conditions

Conditions	Yield
With zirconium(IV) chloride at 20℃; for 0.25h;	100%
With [{(CH3)5Cp}2Zr(CH3CN)2(H2O)][OSO2C6F5]2·CH3CN In neat (no solvent) at 20℃; for 0.166667h; diastereospecific reaction;	99%
With zinc(II) perchlorate hexahydrate at 20℃; for 0.5h;	98%

: 506-68-3
bromocyane

: 106-49-0
p-toluidine

: 10532-64-6
N-(4-methylphenyl)cyanamide

Conditions

Conditions	Yield
With trimethylamine Ambient temperature;	100%
In diethyl ether; tetrahydrofyran at 0℃; for 4h;	95%
With triethylamine In diethyl ether at 0℃;	83%

p-Toluidine Consensus Reports

Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.

p-Toluidine Specification

1.Introduction of p-Toluidine

The p-Toluidine, with its CAS NO.106-49-0, is a kind of white lustrous plates or leaflets with an amine odour. Its Synonyms are 4-Aminotoluene ; 4-Toluidine ; 1-Amino-4-methylbenzene ; 4-Amino-1-methylbenzene ; 4-Methylaniline ; 4-Methylbenzenamine ; Aniline, p-methyl- ; Benzenamine, 4-methyl- and p-Methylbenzenamine. p-Toluidine should be stored in shady and cool warehouse and mainly used in dyes, and in organic chemical manufacturing.

2.Properties of p-Toluidine

(1) Density: 0.992 g/cm3 (2) Flash Point: 84.5 °C (3) Enthalpy of Vaporization: 43.36 kJ/mol
(4) Boiling Point: 197.4 °C at 760 mmHg (5) Melting Point: 43 °C(6) Water Solubility: 1.1 g/100 mL
(7) Storage temperature: 2-8 °C (8) Vapour Pressure of p-Toluidine (CAS NO.106-49-0): 0.379 mmHg at 25 °C

3.Structure descriptors of p-Toluidine

IUPAC Name: 4-methylaniline

InChI: InChI=1S/C7H9N/c1-6-2-4-7(8)5-3-6/h2-5H,8H2,1H3

InChIKey: RZXMPPFPUUCRFN-UHFFFAOYSA-N

Canonical SMILES : CC1=CC=C(C=C1)N

4. Safety information of p-Toluidine

Hazard Codes: Toxic , Dangerous
Risk Statements: 23/24/25-36-40-43-50
R23/24/25: Toxic by inhalation, in contact with skin and if swallowed.
R36: Irritating to eyes.
R40: Limited evidence of a carcinogenic effect.
R43: May cause sensitization by skin contact.
R50: Very toxic to aquatic organisms.
Safety Statements: 28-36/37-45-61
S28: After contact with skin, wash immediately with plenty of soap-suds.
S36/37: Wear suitable protective clothing and gloves.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S61: Avoid release to the environment. Refer to special instructions / safety data sheets.
RIDADR: UN 3451 6.1/PG 2
WGK Germany: 2
RTECS: XU3150000
HazardClass: 6.1
PackingGroup of p-Toluidine (CAS NO.106-49-0): II

5.Toxicity data of p-Toluidine

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
bird - wild	LD50	oral	42mg/kg (42mg/kg)		Toxicology and Applied Pharmacology. Vol. 21, Pg. 315, 1972.
mouse	LD50	intraperitoneal	50mg/kg (50mg/kg)		National Technical Information Service. Vol. AD691-490,
mouse	LD50	oral	330mg/kg (330mg/kg)		Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 25(8), Pg. 50, 1981.
quail	LD50	oral	237mg/kg (237mg/kg)		Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983.
rabbit	LD50	oral	270mg/kg (270mg/kg)		Vsesoyuznyi Institut Nauchnoi i Tekhnicheskoi Informatsii Vol. #4035-77,
rabbit	LD50	skin	890mg/kg (890mg/kg)		BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 31-4/1973,
rat	LC50	inhalation	> 640mg/m3/1H (640mg/m3)		BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 31-4/1973,
rat	LD50	oral	336mg/kg (336mg/kg)	PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Bromatologia i Chemia Toksykologiczna. Vol. 17, Pg. 51, 1984.

Product Name

p-Toluidine

Synthetic route

p-Toluidine Consensus Reports

p-Toluidine Specification

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