Product Name

  • Name

    1,2,3-Trimethylbenzene

  • EINECS 208-394-8
  • CAS No. 526-73-8
  • Article Data93
  • CAS DataBase
  • Density 0.869 g/cm3
  • Solubility 65.51mg/L(25 oC)
  • Melting Point -25 °C(lit.)
  • Formula C9H12
  • Boiling Point 176.766 °C at 760 mmHg
  • Molecular Weight 120.194
  • Flash Point 53.106 °C
  • Transport Information UN 3295 3/PG 3
  • Appearance colourless liquid
  • Safety 16
  • Risk Codes 10-37
  • Molecular Structure Molecular Structure of 526-73-8 (1,2,3-Trimethylbenzene)
  • Hazard Symbols IrritantXi
  • Synonyms Hemimellitol;NSC 5167;
  • PSA 0.00000
  • LogP 2.61180

Synthetic route

epimino-1,2 trimethyl-3,5,5 cyclohexene-3
52378-83-3

epimino-1,2 trimethyl-3,5,5 cyclohexene-3

1,2,3-trimethylbenzene
526-73-8

1,2,3-trimethylbenzene

Conditions
ConditionsYield
With pyridine hydrogenfluoride In hexane at 0℃; for 8h;98%
biphenyl
92-52-4

biphenyl

1,2,3-trimethyl-5-tert-butylbenzene
98-23-7

1,2,3-trimethyl-5-tert-butylbenzene

A

1,2,3-trimethylbenzene
526-73-8

1,2,3-trimethylbenzene

B

4-tert-butylbiphenyl
1625-92-9

4-tert-butylbiphenyl

Conditions
ConditionsYield
With Nafion-H at 130 - 135℃; for 12h;A 80%
B n/a
1,2,3-trimethyl-5-tert-butylbenzene
98-23-7

1,2,3-trimethyl-5-tert-butylbenzene

A

1,2,3-trimethylbenzene
526-73-8

1,2,3-trimethylbenzene

B

4-tert-butylbiphenyl
1625-92-9

4-tert-butylbiphenyl

Conditions
ConditionsYield
With biphenyl; Nafion-H at 130 - 135℃; for 12h;A 80%
B n/a
dihydroxy-methyl-borane
13061-96-6

dihydroxy-methyl-borane

2,6-dimethyl-1-chlorobenzene
6781-98-2

2,6-dimethyl-1-chlorobenzene

1,2,3-trimethylbenzene
526-73-8

1,2,3-trimethylbenzene

Conditions
ConditionsYield
With O4P(3-)*3K(1+)*5H2O; tris(1-adamantyl)phosphine; C28H26N2O8Pd2S2 In tetrahydrofuran at 50℃; for 5h; Suzuki-Miyaura Coupling; Inert atmosphere; Schlenk technique;50%
With 1,2,3-trimethoxybenzene; O4P(3-)*3K(1+)*5H2O; tris(1-adamantyl)phosphine; {2-[((acetyl-κO)amino)phenyl-κC](tri-1-adamantylphosphine)palladium}(p-toluenesulfonate) In tetrahydrofuran at 50℃; for 5h; Suzuki-Miyaura Coupling;50%
o-xylene
95-47-6

o-xylene

A

2-Ethyltoluene
611-14-3

2-Ethyltoluene

B

1,2,4-Trimethylbenzene
95-63-6

1,2,4-Trimethylbenzene

C

1,2,3-trimethylbenzene
526-73-8

1,2,3-trimethylbenzene

D

2-methyl-benzyl alcohol
89-95-2

2-methyl-benzyl alcohol

E

1,2-bis(2-methylphenyl)ethane
952-80-7

1,2-bis(2-methylphenyl)ethane

Conditions
ConditionsYield
With peracetic acid at 20 - 22℃; Product distribution; Irradiation; λ>2900 Angstroem;A 9.3%
B n/a
C n/a
D 36.9%
E n/a
m-xylene
108-38-3

m-xylene

A

1-Methyl-3-ethylbenzene
620-14-4

1-Methyl-3-ethylbenzene

B

1,2,4-Trimethylbenzene
95-63-6

1,2,4-Trimethylbenzene

C

1,2,3-trimethylbenzene
526-73-8

1,2,3-trimethylbenzene

D

1,2-di-m-tolylethane
4662-96-8

1,2-di-m-tolylethane

E

3-methylbenzyl alcohol
587-03-1

3-methylbenzyl alcohol

F

1,3,5-trimethyl-benzene
108-67-8

1,3,5-trimethyl-benzene

Conditions
ConditionsYield
With peracetic acid at 20 - 22℃; Product distribution; Irradiation; λ>2900 Angstroem;A 7.4%
B n/a
C n/a
D n/a
E 30%
F n/a
tetrachloromethane
56-23-5

tetrachloromethane

1,2,3-trimethylbenzene
526-73-8

1,2,3-trimethylbenzene

Conditions
ConditionsYield
With aluminium trichloride at 95℃; Einleiten von Methylchlorid;
1,1,2,3-tetramethylcyclohexane
6783-92-2

1,1,2,3-tetramethylcyclohexane

1,2,3-trimethylbenzene
526-73-8

1,2,3-trimethylbenzene

Conditions
ConditionsYield
at 300℃; Leiten ueber Platin-Aluminiumoxyd;
4,4'-di-tert-butyl-2,2',6,6'-tetramethyldiphenylmethane
65338-71-8

4,4'-di-tert-butyl-2,2',6,6'-tetramethyldiphenylmethane

1,2,3-trimethylbenzene
526-73-8

1,2,3-trimethylbenzene

Conditions
ConditionsYield
With molybdenum oxide-aluminium oxide; benzene at 450℃;
1,2,3-trimethyl-cyclohexene
72312-48-2

1,2,3-trimethyl-cyclohexene

1,2,3-trimethylbenzene
526-73-8

1,2,3-trimethylbenzene

Conditions
ConditionsYield
With chromium corundum at 525℃;
2,3-dimethylbenzyl chloride
13651-55-3

2,3-dimethylbenzyl chloride

1,2,3-trimethylbenzene
526-73-8

1,2,3-trimethylbenzene

Conditions
ConditionsYield
With tetrahydrofuran; lithium aluminium tetrahydride; lithium hydride
(2,3-dimethylphenyl)methanol
13651-14-4

(2,3-dimethylphenyl)methanol

1,2,3-trimethylbenzene
526-73-8

1,2,3-trimethylbenzene

Conditions
ConditionsYield
With ethanol; barium containing copper chromite at 220 - 235℃; under 73550.8 - 139746 Torr; Hydrogenolyse;
With platinum Hydrogenation;
1,2,3-trimethyl-5-tert-butylbenzene
98-23-7

1,2,3-trimethyl-5-tert-butylbenzene

m-xylene
108-38-3

m-xylene

1,2,3-trimethylbenzene
526-73-8

1,2,3-trimethylbenzene

Conditions
ConditionsYield
With hydrogen fluoride
m-xylene
108-38-3

m-xylene

benzene
71-43-2

benzene

A

1,2,3-trimethylbenzene
526-73-8

1,2,3-trimethylbenzene

B

toluene
108-88-3

toluene

Conditions
ConditionsYield
at 538℃; Leiten ueber Aluminiumoxyd-Siliciumdioxyd;
m-xylene
108-38-3

m-xylene

A

1,2,3-trimethylbenzene
526-73-8

1,2,3-trimethylbenzene

B

toluene
108-88-3

toluene

Conditions
ConditionsYield
at 538℃; Leiten ueber Aluminiumoxyd-Siliciumdioxyd;
crotonaldehyde
123-73-9

crotonaldehyde

1,2,3-trimethylbenzene
526-73-8

1,2,3-trimethylbenzene

Conditions
ConditionsYield
With Z-piperylene; 1-methylbuta-1,3-diene at 200℃; Reaktion ueber mehrere Stufen;
1-iodo-2,3-dimethylbenzene
31599-60-7

1-iodo-2,3-dimethylbenzene

methyl iodide
74-88-4

methyl iodide

1,2,3-trimethylbenzene
526-73-8

1,2,3-trimethylbenzene

Conditions
ConditionsYield
With diethyl ether; sodium
o-xylene
95-47-6

o-xylene

A

para-xylene
106-42-3

para-xylene

B

1,2,4-Trimethylbenzene
95-63-6

1,2,4-Trimethylbenzene

C

1,2,3-trimethylbenzene
526-73-8

1,2,3-trimethylbenzene

D

m-xylene
108-38-3

m-xylene

Conditions
ConditionsYield
With hydrogen; H Mordenite at 350℃; under 760 Torr; for 7h; Product distribution; variation of the catalyst and reaction time;
o-xylene
95-47-6

o-xylene

A

para-xylene
106-42-3

para-xylene

B

1,2,4-Trimethylbenzene
95-63-6

1,2,4-Trimethylbenzene

C

1,2,3-trimethylbenzene
526-73-8

1,2,3-trimethylbenzene

D

m-xylene
108-38-3

m-xylene

E

toluene
108-88-3

toluene

F

1,3,5-trimethyl-benzene
108-67-8

1,3,5-trimethyl-benzene

Conditions
ConditionsYield
aluminum oxide; silica gel at 230℃; Product distribution; further catalysts, percent of conversion;
hidrogenated Ag3PW12O40 at 300℃; under 760 Torr; for 0.5h; Product distribution; isomerization, disproportionation, investigation of the catalytic mechanism, other tungstophosphate catalysts, other times;A 17.0 % Chromat.
B n/a
C n/a
D 51.8 % Chromat.
E 16.2 % Chromat.
F n/a
1,2,4-Trimethylbenzene
95-63-6

1,2,4-Trimethylbenzene

A

methane
34557-54-5

methane

B

1,2,3-trimethylbenzene
526-73-8

1,2,3-trimethylbenzene

Conditions
ConditionsYield
With sulfuric acid; pyrographite at 99.9℃;
1,2,4-Trimethylbenzene
95-63-6

1,2,4-Trimethylbenzene

A

o-xylene
95-47-6

o-xylene

B

para-xylene
106-42-3

para-xylene

C

1,2,3-trimethylbenzene
526-73-8

1,2,3-trimethylbenzene

D

1,2,3,4-Tetramethylbenzene
488-23-3

1,2,3,4-Tetramethylbenzene

E

m-xylene
108-38-3

m-xylene

F

1,3,5-trimethyl-benzene
108-67-8

1,3,5-trimethyl-benzene

Conditions
ConditionsYield
With HY zeolite at 200℃; under 12.8 Torr; Product distribution; Rate constant; Equilibrium constant; kinetics, Ea, mechanism; var. temp.;
1,2,4-Trimethylbenzene
95-63-6

1,2,4-Trimethylbenzene

A

1,2,3-trimethylbenzene
526-73-8

1,2,3-trimethylbenzene

B

1,3,5-trimethyl-benzene
108-67-8

1,3,5-trimethyl-benzene

Conditions
ConditionsYield
HY zeolite Product distribution; equilibrium; various catalysts, HM and HO zeolites;
With H-TsVM zeolite effect of conditions of pretreating of zeolite on conversion and selectivity in isomerization of pseudocumene;
ZSM-5 zeolite in acid form, alumina and acetic acid mixed, extruded and calcined at 275 - 340℃; under 37503.8 Torr; for 145 - 1367h; Conversion of starting material;A 2.8 - 8.5 %Chromat.
B 7 - 23.4 %Chromat.
1,5-Dimethylencyclooctan
18216-01-8

1,5-Dimethylencyclooctan

A

para-xylene
106-42-3

para-xylene

B

1,2,3-trimethylbenzene
526-73-8

1,2,3-trimethylbenzene

C

<3.3.2>propellane
27613-46-3

<3.3.2>propellane

D

m-xylene
108-38-3

m-xylene

E

toluene
108-88-3

toluene

F

benzene
71-43-2

benzene

Conditions
ConditionsYield
at 450.1℃; Rate constant; Kinetics; Thermodynamic data; var. temp., ΔH(excit.), ΔS(excit.), Ea, log A;
Trimethyl-(3,4,5-trimethyl-phenyl)-silane
112277-74-4

Trimethyl-(3,4,5-trimethyl-phenyl)-silane

1,2,3-trimethylbenzene
526-73-8

1,2,3-trimethylbenzene

Conditions
ConditionsYield
With perchloric acid at 50℃; Rate constant;
Trimethyl-(2,3,4-trimethyl-phenyl)-silane
112277-73-3

Trimethyl-(2,3,4-trimethyl-phenyl)-silane

1,2,3-trimethylbenzene
526-73-8

1,2,3-trimethylbenzene

Conditions
ConditionsYield
With perchloric acid at 50℃; Rate constant;
methanol
67-56-1

methanol

m-xylene
108-38-3

m-xylene

A

1,2,4-Trimethylbenzene
95-63-6

1,2,4-Trimethylbenzene

B

1,2,3-trimethylbenzene
526-73-8

1,2,3-trimethylbenzene

Conditions
ConditionsYield
Si/Al large-pore zeolite Product distribution; different zeolite catalysts;
m-xylene
108-38-3

m-xylene

A

o-xylene
95-47-6

o-xylene

B

para-xylene
106-42-3

para-xylene

C

1,2,3-trimethylbenzene
526-73-8

1,2,3-trimethylbenzene

D

toluene
108-88-3

toluene

Conditions
ConditionsYield
alumina-pillared montmorillonite at 354.9℃; for 0.5h; Yield given. Further byproducts given. Yields of byproduct given;
With aluminum-doped cristabolite at 350℃; for 0.166667h; Catalytic behavior; Reagent/catalyst;
m-xylene
108-38-3

m-xylene

A

o-xylene
95-47-6

o-xylene

B

para-xylene
106-42-3

para-xylene

C

1,2,4-Trimethylbenzene
95-63-6

1,2,4-Trimethylbenzene

D

1,2,3-trimethylbenzene
526-73-8

1,2,3-trimethylbenzene

E

toluene
108-88-3

toluene

F

1,3,5-trimethyl-benzene
108-67-8

1,3,5-trimethyl-benzene

Conditions
ConditionsYield
Na0,8H54,1(AlO2)54,9(SiO2)137,1 at 350℃; under 760 Torr; Product distribution; also cracking of heptane, various catalysts;
m-xylene
108-38-3

m-xylene

A

o-xylene
95-47-6

o-xylene

B

para-xylene
106-42-3

para-xylene

C

1,2,4-Trimethylbenzene
95-63-6

1,2,4-Trimethylbenzene

D

1,2,3-trimethylbenzene
526-73-8

1,2,3-trimethylbenzene

E

1,3,5-trimethyl-benzene
108-67-8

1,3,5-trimethyl-benzene

Conditions
ConditionsYield
With hydrogen; H Mordenite at 350℃; under 760 Torr; for 7h; Product distribution; variation of the catalyst;
m-xylene
108-38-3

m-xylene

A

o-xylene
95-47-6

o-xylene

B

1,2,4-Trimethylbenzene
95-63-6

1,2,4-Trimethylbenzene

C

1,2,3-trimethylbenzene
526-73-8

1,2,3-trimethylbenzene

D

1,3,5-trimethyl-benzene
108-67-8

1,3,5-trimethyl-benzene

Conditions
ConditionsYield
alumina-pillared montmorillonite at 354.9℃; for 0.5h; Yield given. Further byproducts given. Yields of byproduct given;
1,2,3-trimethylbenzene
526-73-8

1,2,3-trimethylbenzene

1-bromo-2,3,4-trimethylbenzene
40101-33-5

1-bromo-2,3,4-trimethylbenzene

Conditions
ConditionsYield
With benzyltrimethylazanium tribroman-2-uide; zinc(II) chloride In acetic acid for 1h; Ambient temperature;99%
With copper(ll) bromide; aluminum oxide In tetrachloromethane at 80℃; for 1h;87%
With copper(ll) bromide; aluminum oxide In tetrachloromethane at 80℃; for 1h; Product distribution;87%
1,2,3-trimethylbenzene
526-73-8

1,2,3-trimethylbenzene

1,2,3-tribromo-4,5,6-trimethyl-benzene
124312-42-1

1,2,3-tribromo-4,5,6-trimethyl-benzene

Conditions
ConditionsYield
With benzyltrimethylazanium tribroman-2-uide; zinc(II) chloride In acetic acid at 70℃; for 24h;99%
With bromine at 0℃;
1,2,3-trimethylbenzene
526-73-8

1,2,3-trimethylbenzene

1-iodo-2,3,4-trimethylbenzene
41381-33-3

1-iodo-2,3,4-trimethylbenzene

Conditions
ConditionsYield
With iodine; mercury(II) nitrate In dichloromethane at 20℃; for 14h;98%
With tetrafluoroboric acid; [bis(pyridine)iodine]+ tetrafluoroborate In diethyl ether; dichloromethane for 0.1h; Ambient temperature;95%
With Iodine monochloride In tetrachloromethane at 20℃; for 6h; or I2, HIO4, H2SO4, aq.AcOH, 12h, 70 deg C;90%
1,2,3-trimethylbenzene
526-73-8

1,2,3-trimethylbenzene

5-azidopentanoic chloride
79583-99-6

5-azidopentanoic chloride

C14H19NO
1415414-07-1

C14H19NO

Conditions
ConditionsYield
Stage #1: 1,2,3-trimethylbenzene; 5-azidopentanoyl chloride In dichloromethane at 20℃; for 0.166667h;
Stage #2: With boron trifluoride diethyl etherate In dichloromethane at 20℃; for 0.416667h;
95%
Stage #1: 1,2,3-trimethylbenzene; 5-azidopentanoyl chloride In dichloromethane at 20℃; for 0.166667h;
Stage #2: With ethylaluminum dichloride In dichloromethane at 20℃; for 0.416667h;
95%
4-azidobutanoyl chloride
14468-88-3

4-azidobutanoyl chloride

1,2,3-trimethylbenzene
526-73-8

1,2,3-trimethylbenzene

C13H17NO
1415414-06-0

C13H17NO

Conditions
ConditionsYield
Stage #1: 4-azidobutanoyl chloride; 1,2,3-trimethylbenzene In dichloromethane at 20℃; for 0.166667h;
Stage #2: With boron trifluoride diethyl etherate In dichloromethane at 20℃; for 0.416667h;
94%
Stage #1: 4-azidobutanoyl chloride; 1,2,3-trimethylbenzene In dichloromethane at 20℃; for 0.166667h;
Stage #2: With ethylaluminum dichloride In dichloromethane at 20℃; for 0.416667h;
94%
3-Methylbutenoic acid
541-47-9

3-Methylbutenoic acid

1,2,3-trimethylbenzene
526-73-8

1,2,3-trimethylbenzene

3-methyl-3-(3,4,5-trimethylphenyl)butanoic acid
5452-54-0

3-methyl-3-(3,4,5-trimethylphenyl)butanoic acid

Conditions
ConditionsYield
With aluminum (III) chloride at 20℃; for 48h; Cooling with ice;92%
With aluminium trichloride at -10℃;
1,2,3-trimethylbenzene
526-73-8

1,2,3-trimethylbenzene

methyl 2-(2-chlorophenyl)-2-diazoacetate
264882-00-0

methyl 2-(2-chlorophenyl)-2-diazoacetate

methyl 2-(2-chlorophenyl)-2-mesitylacetate

methyl 2-(2-chlorophenyl)-2-mesitylacetate

Conditions
ConditionsYield
With (triphenylphosphine)gold(I) chloride; silver trifluoromethanesulfonate at 20℃; for 0.0666667h; Schlenk technique;92%
1,2,3-trimethylbenzene
526-73-8

1,2,3-trimethylbenzene

1,2,3-tris-trideuteriomethyl-benzene
29636-66-6

1,2,3-tris-trideuteriomethyl-benzene

Conditions
ConditionsYield
With water-d2; platinum on activated charcoal90%
Dichloromethyl methyl ether
4885-02-3

Dichloromethyl methyl ether

1,2,3-trimethylbenzene
526-73-8

1,2,3-trimethylbenzene

2,3,4-trimethylbenzaldehyde
34341-28-1

2,3,4-trimethylbenzaldehyde

Conditions
ConditionsYield
With titanium tetrachloride In dichloromethane at 0 - 20℃; for 4h;90%
With titanium tetrachloride In dichloromethane90%
With tin(IV) chloride In dichloromethane9.2 g (70%)
methyl thiocyanate
556-64-9

methyl thiocyanate

1,2,3-trimethylbenzene
526-73-8

1,2,3-trimethylbenzene

isobutyraldehyde
78-84-2

isobutyraldehyde

A

3,3,6,7,8-pentamethyl-3,4-dihydro-2H-isoquinolin-1-one

3,3,6,7,8-pentamethyl-3,4-dihydro-2H-isoquinolin-1-one

B

3,3,5,6,7-pentamethyl-3,4-dihydro-2H-isoquinolin-1-one

3,3,5,6,7-pentamethyl-3,4-dihydro-2H-isoquinolin-1-one

Conditions
ConditionsYield
Stage #1: methyl thiocyanate; 1,2,3-trimethylbenzene; isobutyraldehyde With sulfuric acid; water
Stage #2: With sodium hydroxide In water; acetic acid for 1h; Heating;
A n/a
B 88%
6-azido-hexanoyl chloride
5515-02-6

6-azido-hexanoyl chloride

1,2,3-trimethylbenzene
526-73-8

1,2,3-trimethylbenzene

C15H21NO
1415414-10-6

C15H21NO

Conditions
ConditionsYield
Stage #1: 6-azido-hexanoyl chloride; 1,2,3-trimethylbenzene In dichloromethane at 20℃; for 0.166667h;
Stage #2: With boron trifluoride diethyl etherate In dichloromethane at 20℃; for 0.5h;
87%
Stage #1: 6-azido-hexanoyl chloride; 1,2,3-trimethylbenzene In dichloromethane at 20℃; for 0.166667h;
Stage #2: With ethylaluminum dichloride In dichloromethane at 20℃; for 0.5h;
87%
ethyl 2,4-dimethyl-4-pentenoate
90646-75-6

ethyl 2,4-dimethyl-4-pentenoate

1,2,3-trimethylbenzene
526-73-8

1,2,3-trimethylbenzene

ethyl 2,4-dimethyl-(3,4,5-trimethyl-1-phenyl)-pentanoate
1237141-81-9

ethyl 2,4-dimethyl-(3,4,5-trimethyl-1-phenyl)-pentanoate

Conditions
ConditionsYield
AlCl382%
AlCl382%
1,2,3-trimethylbenzene
526-73-8

1,2,3-trimethylbenzene

4-chloro-1,2,3-trimethylbenzene
65235-47-4

4-chloro-1,2,3-trimethylbenzene

Conditions
ConditionsYield
With benzyl(trimethyl)ammonium tetrachloroiodate In acetic acid for 20h; Ambient temperature;81%
With copper dichloride; aluminum oxide In chlorobenzene at 110℃; for 4h;80%
With copper dichloride; aluminum oxide In chlorobenzene at 110℃; for 4h; Product distribution;80%
With chloroform; iodine; chlorine at 0℃;
1,2,3-trimethylbenzene
526-73-8

1,2,3-trimethylbenzene

benzene-1,2,3-tricarboxlic acid
569-51-7

benzene-1,2,3-tricarboxlic acid

Conditions
ConditionsYield
With air; acetic acid; 1N,3N,5N-trihydroxy-1,3,5-triazin-2,4,6[1H,3H,5H]-trione; cobalt(II) acetate; zirconyl acetate at 150℃; under 15200 Torr; for 6h;81%
With sodium hydroxide; potassium permanganate In water for 2h; Heating;80%
Stage #1: 1,2,3-trimethylbenzene With potassium permanganate; potassium hydroxide In water at 95℃; for 4.08333h; Reflux;
Stage #2: With sulfuric acid In water at 45℃; for 2h; Reagent/catalyst;
80.67%
With nitric acid
1,2,3-trimethylbenzene
526-73-8

1,2,3-trimethylbenzene

Gallium trichloride
13450-90-3

Gallium trichloride

mercury dichloride

mercury dichloride

[Hg(η2-C6H3-1,2,3-Me3)2(GaCl4)2]
383884-74-0

[Hg(η2-C6H3-1,2,3-Me3)2(GaCl4)2]

Conditions
ConditionsYield
In neat (no solvent) soln. was heated at ca. 100°C for 15 min; crystals were grown over a few days at -19°C; NMR;80%
1,2,3-trimethylbenzene
526-73-8

1,2,3-trimethylbenzene

benzaldehyde
100-52-7

benzaldehyde

Conditions
ConditionsYield
With Acetyl bromide; zinc dibromide In benzene at 50℃; for 3h;78%
1,2,3-trimethylbenzene
526-73-8

1,2,3-trimethylbenzene

2-bromomethyl-1,3-bis(tribromomethyl)benzene

2-bromomethyl-1,3-bis(tribromomethyl)benzene

Conditions
ConditionsYield
With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) In tetrachloromethane for 20h; Irradiation;77%
1,2,3-trimethylbenzene
526-73-8

1,2,3-trimethylbenzene

2,3,4-trimethylbenzaldehyde
34341-28-1

2,3,4-trimethylbenzaldehyde

Conditions
ConditionsYield
aluminium trichloride In (2S)-N-methyl-1-phenylpropan-2-amine hydrate74.9%
With zinc(II) cyanide; aluminium trichloride; benzene Einleiten von HCl und anschliessend Hydrolyse;
Multi-step reaction with 2 steps
1: Br2
2: (i) EtMgBr, (ii) /BRN= 605384/, (iii) H2O
View Scheme
2-bromoisobutyric acid bromide
20769-85-1

2-bromoisobutyric acid bromide

1,2,3-trimethylbenzene
526-73-8

1,2,3-trimethylbenzene

2,5,6,7-tetramethyl-1-indanone

2,5,6,7-tetramethyl-1-indanone

Conditions
ConditionsYield
With aluminum (III) chloride In dichloromethane at 0 - 40℃; for 15h;70%
AlCl3 In dichloromethane
aluminium trichloride
7446-70-0

aluminium trichloride

1,2,3-trimethylbenzene
526-73-8

1,2,3-trimethylbenzene

mercury dichloride

mercury dichloride

[Hg(η2-C6H3-1,2,3-Me3)2(AlCl4)2]
383884-73-9

[Hg(η2-C6H3-1,2,3-Me3)2(AlCl4)2]

Conditions
ConditionsYield
In neat (no solvent) soln. was heated at ca. 100°C for 15 min; crystals were grown over a few days at -19°C; NMR;70%
1,2,3-trimethylbenzene
526-73-8

1,2,3-trimethylbenzene

1,2,3-triiodo-4,5,6-trimethylbenzene
41694-36-4

1,2,3-triiodo-4,5,6-trimethylbenzene

Conditions
ConditionsYield
With iodine; Selectfluor In acetonitrile at 55 - 65℃; for 24h;69%
1,2,3-trimethylbenzene
526-73-8

1,2,3-trimethylbenzene

1-bromo-2-(triisopropylsilyl)acetylene
111409-79-1

1-bromo-2-(triisopropylsilyl)acetylene

triisopropyl((3,4,5-trimethylphenyl)ethynyl)silane

triisopropyl((3,4,5-trimethylphenyl)ethynyl)silane

Conditions
ConditionsYield
With 1,4-pyrazine; 1,1,1,3',3',3'-hexafluoro-propanol; (S)-2-acetylamino-3-phenylpropanoic acid; palladium diacetate; silver(l) oxide at 60℃; for 18h; Schlenk technique; Sealed tube; regioselective reaction;69%
1,2,3-trimethylbenzene
526-73-8

1,2,3-trimethylbenzene

4-fluoro-3,4,5-trimethyl-cyclohexa-2,5-dienone

4-fluoro-3,4,5-trimethyl-cyclohexa-2,5-dienone

Conditions
ConditionsYield
With water; Selectfluor In acetonitrile at 55℃; for 23h;68%
With water; Selectfluor In acetonitrile at 20℃; Kinetics;
1,2,3-trimethylbenzene
526-73-8

1,2,3-trimethylbenzene

2,3,4-Trimethylnitrosobenzene

2,3,4-Trimethylnitrosobenzene

Conditions
ConditionsYield
With nitrosonium tetrafluoroborate In acetonitrile at 25℃; for 5h;67%
N-acetylindole
576-15-8

N-acetylindole

1,2,3-trimethylbenzene
526-73-8

1,2,3-trimethylbenzene

1-acetyl-2-(2,3,4-trimethylphenyl)-2,3-dihydro-1H-indole

1-acetyl-2-(2,3,4-trimethylphenyl)-2,3-dihydro-1H-indole

Conditions
ConditionsYield
With 1,1,1,3',3',3'-hexafluoro-propanol; boron trifluoride diethyl etherate at 20℃; for 4h; Inert atmosphere;67%
1,2,3-trimethylbenzene
526-73-8

1,2,3-trimethylbenzene

copper(l) cyanide

copper(l) cyanide

trimethylbenzonitrile

trimethylbenzonitrile

Conditions
ConditionsYield
With 3-(trifluoromethyl)quinoline; palladium diacetate; silver fluoride; N-acetylglycine at 90℃; for 18h; regioselective reaction;67%
styrene
292638-84-7

styrene

1,2,3-trimethylbenzene
526-73-8

1,2,3-trimethylbenzene

(E)-3,4,5-trimethyl-1-styrylbenzene

(E)-3,4,5-trimethyl-1-styrylbenzene

Conditions
ConditionsYield
With di-μ-acetatotetrakis(dihaptoethene)dirhodium(I); copper(II) dipivaloate; Trimethylacetic acid at 165℃; for 48h; Sealed tube;67%

1,2,3-Trimethylbenzene Chemical Properties

Molecular Formula: C9H12
Molecular Weight: 120.19
EINECS: 208-394-8
Melting point: -25 °C(lit.)
Boiling point: 175-176 °C(lit.)
Density: 0.894 g/mL at 25 °C(lit.)
Vapor density: 4.15 (vs air)
Vapor pressure: 3.4 mm Hg ( 37.7 °C)
Refractive index: n20/D 1.513(lit.)
Flash point: 119 °F
Appearance: Colourless liquid
Structure of 1,2,3-Trimethylbenzene (CAS NO.526-73-8):
                   
IUPAC Name: 1,2,3-Trimethylbenzene

1,2,3-Trimethylbenzene Uses

 1,2,3-Trimethylbenzene (CAS NO.526-73-8) is mainly used for the preparation of aniline dyes, alkyd resins, polyester resins,etc.

1,2,3-Trimethylbenzene Toxicity Data With Reference

1.    

orl-rat LDLo:5000 mg/kg

    AMIHAB    AMA Archives of Industrial Health. 19 (1959),403.

1,2,3-Trimethylbenzene Consensus Reports

Reported in EPA TSCA Inventory.

1,2,3-Trimethylbenzene Safety Profile

Mildly toxic by ingestion. Flammable liquid when exposed to heat, sparks, or flame. To fight fire, use water spray, mist, dry chemical, CO2, foam. When heated to decomposition it emits acrid smoke and irritating fumes.
Hazard Codes of 1,2,3-Trimethylbenzene (CAS NO.526-73-8): IrritantXi
Risk Statements: 10-37
R10:Flammable. 
R37:Irritating to respiratory system
Safety Statements: 16 
S16:Keep away from sources of ignition.

1,2,3-Trimethylbenzene Standards and Recommendations

OSHA PEL: TWA 25 ppm
ACGIH TLV: TWA 25 ppm
DFG MAK: 20 ppm

1,2,3-Trimethylbenzene Specification

 1,2,3-Trimethylbenzene , its cas register number is 526-73-8. It also can be called Hemimellitene ; and Benzene, 1,2,3-trimethyl- .

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