2-Acetylbutyrolactone supplier

Name
2-Acetylbutyrolactone
EINECS 208-235-2
CAS No. 517-23-7
Article Data32
CAS DataBase
Density 1.191 g/cm³
Solubility 310 g/L (20 °C) in water
Melting Point <25 °C
Formula C₆H₈O₃
Boiling Point 253.078 °C at 760 mmHg
Molecular Weight 128.128
Flash Point 128.244 °C
Transport Information
Appearance Colorless to light yellow liquid
Safety 26-36-37/39
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Acetoaceticacid, 2-(2-hydroxyethyl)-, g-lactone (6CI,7CI);2-Acetyl-g-butyrolactone;2-Acetylbutanolide;2-Oxo-3-acetyltetrahydrofuran;3-Acetyl-4,5-dihydro-2(3H)-furanone;3-Acetyl-4,5-dihydrofuran-2-one;3-Acetyldihydro-2(3H)-furanone;3-Acetyldihydrofuran-2-one;3-Acetyltetrahydro-2-furanone;Dihydro-3-acetyl-2(3H)-furanone;NSC 2019;a-(2-Hydroxyethyl)acetoacetic acidg-lactone;a-Acetobutyrolactone;a-Acetyl-g-butyrolactone;a-Acetyl-g-hydroxybutyric acid g-lactone;a-Acetylbutyrolactone;
PSA 43.37000
LogP 0.13850

Synthetic route

: α-acetyl-γ-butyrolactone sodium

A: 60-35-5
acetamide

B: 517-23-7
3-acetyl-2-oxo-4,5-dihydrofuran

Conditions

Conditions	Yield
With ethyl hydrazine hydrochloride In methanol at 10 - 20℃; for 2h; Temperature;	A 98.9% B 98.29%

: 96-48-0
4-butanolide

: 79-20-9
acetic acid methyl ester

: 517-23-7
3-acetyl-2-oxo-4,5-dihydrofuran

Conditions

Conditions	Yield
Stage #1: 4-butanolide; acetic acid methyl ester With sodium methylate In methanol at 45 - 90℃; under 750.075 Torr; for 10h; Inert atmosphere; Large scale; Stage #2: With carbon dioxide In methanol; water at 0 - 35℃; under 6000.6 Torr; for 0.5h; Temperature; Pressure; Reagent/catalyst; Large scale;	96%

: 96-48-0
4-butanolide

: 141-78-6
ethyl acetate

: 517-23-7
3-acetyl-2-oxo-4,5-dihydrofuran

Conditions

Conditions	Yield
With sodium ethanolate at 75℃; for 10h; Reflux;	93%
Stage #1: 4-butanolide; ethyl acetate With sodium methylate at 50 - 100℃; for 5h; Autoclave; Stage #2: With sulfuric acid at -5 - 5℃; for 5h; pH=6 - 7;	83%
With sodium at 80℃; for 8h; Mechanism;

: 96-48-0
4-butanolide

: 75-07-0
acetaldehyde

: 517-23-7
3-acetyl-2-oxo-4,5-dihydrofuran

Conditions

Conditions	Yield
With sodium hydrogencarbonate In ethyl acetate at 60 - 95℃; under 750.075 - 7500.75 Torr; for 3.5h; Solvent; Temperature; Reagent/catalyst; Autoclave;	79.31%

: 75-21-8
oxirane

: 105-45-3
acetoacetic acid methyl ester

: 517-23-7
3-acetyl-2-oxo-4,5-dihydrofuran

Conditions

Conditions	Yield
With sodium hydroxide In ethanol; water at -5 - 0℃; for 50h;	78%
With triethylamine In methanol at 5 - 95℃; under 1500.15 - 2250.23 Torr; for 2.15 - 5h; Product distribution / selectivity;	40.4%
With N,N,N',N'-tetramethylguanidine In methanol at 5 - 65℃; under 1500.15 - 2250.23 Torr; for 1.15 - 6.18333h; Product distribution / selectivity;	30.8%

: 96-48-0
4-butanolide

: 108-24-7
acetic anhydride

: 517-23-7
3-acetyl-2-oxo-4,5-dihydrofuran

Conditions

Conditions	Yield
Stage #1: 4-butanolide With lithium hexamethyldisilazane In tetrahydrofuran at -78℃; for 0.25h; Inert atmosphere; Stage #2: acetic anhydride In tetrahydrofuran at -78℃; for 1h; Inert atmosphere;	42%

: 75-21-8
oxirane

: 64-17-5
ethanol

: 1007476-32-5
sodium ethyl acetylacetate enolate

: 517-23-7
3-acetyl-2-oxo-4,5-dihydrofuran

...Expand

: 75-21-8
oxirane

: 1007476-32-5
sodium ethyl acetylacetate enolate

: 517-23-7
3-acetyl-2-oxo-4,5-dihydrofuran

Conditions

Conditions	Yield
With ethanol

: 64-17-5
ethanol

: 1007476-32-5
sodium ethyl acetylacetate enolate

: 107-07-3
2-chloro-ethanol

: 517-23-7
3-acetyl-2-oxo-4,5-dihydrofuran

...Expand

: 75-21-8
oxirane

: 141-97-9
ethyl acetoacetate

: 517-23-7
3-acetyl-2-oxo-4,5-dihydrofuran

Conditions

Conditions	Yield
With sodium hydroxide 1.) water, EtOH, 0 deg C, 30 min, 2.) 0 - 5 deg C, 72 h; Yield given. Multistep reaction;
With sodium hydroxide; sulfuric acid In water; ethylene glycol

: 96-48-0
4-butanolide

: 141-52-6
sodium ethanolate

: 141-78-6
ethyl acetate

A: 517-23-7
3-acetyl-2-oxo-4,5-dihydrofuran

B: 1071-73-4
5-Hydroxy-2-pentanone

C: 999-10-0
ethyl 4-hydroxybutanoate

D: 25560-91-2
ethyl 4-(acetyloxy)butanoate

E: 141-97-9
ethyl acetoacetate

F: 65652-24-6
α-(2-Tetrahydrofuranylidene)-γ-butyrolactone

Conditions

Conditions	Yield
at 100℃; under 1064 Torr; for 0.5h; Product distribution; various molar ratio of the reagents, other temp., other pressure, other time;

...Expand

: 96-48-0
4-butanolide

: 75-36-5
acetyl chloride

: 517-23-7
3-acetyl-2-oxo-4,5-dihydrofuran

Conditions

Conditions	Yield
With 18-crown-6 ether 1.) THF, RT, 15 min, 2.) THF, RT, 3 h; Yield given. Multistep reaction;

: 64620-59-3
3-<1-(N-phenylamino)-ethylidene>-4,5-dihydro-2(3H)-furanone

A: 517-23-7
3-acetyl-2-oxo-4,5-dihydrofuran

B: 62-53-3
aniline

Conditions

Conditions	Yield
With water at 25℃; Rate constant; Mechanism;

: 2280-44-6
D-Glucose

: 517-23-7
3-acetyl-2-oxo-4,5-dihydrofuran

Conditions

Conditions	Yield
With aluminium trichloride; Trioxane In methanol Dehydration; Heating;

: 96-48-0
4-butanolide

: 141-78-6
ethyl acetate

A: 517-23-7
3-acetyl-2-oxo-4,5-dihydrofuran

B acetoacetic acid ethyl ester and tetrahydro-<2,3'>bifuryliden-2'-one: acetoacetic acid ethyl ester and tetrahydro-<2,3'>bifuryliden-2'-one

Conditions

Conditions	Yield
With sodium

...Expand

: 7647-01-0
hydrogenchloride

: 412012-07-8
2-acetyl-2-(methylsulfanyl-methyl)-succinic acid diethyl ester

A: 517-23-7
3-acetyl-2-oxo-4,5-dihydrofuran

B: 89533-75-5
3-methylene-4-oxopentanoic acid

C 3--4-oxo-valeric acid: 3--4-oxo-valeric acid

Conditions

Conditions	Yield
10 h Erhitzen.;

...Expand

: 96-48-0
4-butanolide

: 1258864-02-6
C19H20ClNO4

: 517-23-7
3-acetyl-2-oxo-4,5-dihydrofuran

Conditions

Conditions	Yield
With lithium diisopropyl amide In tetrahydrofuran at -78℃;

: 96-48-0
4-butanolide

: 75-07-0
acetaldehyde

: 141-78-6
ethyl acetate

: 517-23-7
3-acetyl-2-oxo-4,5-dihydrofuran

Conditions

Conditions	Yield
With sodium carbonate at 44 - 80℃; for 8.66667h; Temperature; Autoclave;

...Expand

: 517-23-7
3-acetyl-2-oxo-4,5-dihydrofuran

: 106-95-6
allyl bromide

: 3-(1-Hydroxy-1-methyl-but-3-enyl)-dihydro-furan-2-one

Conditions

Conditions	Yield
With hydrogenchloride; indium In methanol; water for 10h; Ambient temperature;	100%

: 517-23-7
3-acetyl-2-oxo-4,5-dihydrofuran

: 107-05-1
3-chloroprop-1-ene

: 3-(1-Hydroxy-1-methyl-but-3-enyl)-dihydro-furan-2-one

Conditions

Conditions	Yield
With hydrogenchloride; indium In methanol; water for 10h; Ambient temperature;	100%
With tin In hydrogenchloride; methanol for 20h; Product distribution; Ambient temperature; other reagent, solvent, reaction time; also with allyl bromide;	90%

: 517-23-7
3-acetyl-2-oxo-4,5-dihydrofuran

: 75-77-4
chloro-trimethyl-silane

: 133400-76-7
4-<1-(trimethylsiloxy)ethenyl>-5-(trimethylsiloxy)-2,3-dihydrofuran

Conditions

Conditions	Yield
With lithium diisopropyl amide In tetrahydrofuran at -78 - 20℃; for 1h;	100%

: 517-23-7
3-acetyl-2-oxo-4,5-dihydrofuran

: 2986-00-7
3-acetyl-3-chlorodihydrofuran-2(3H)-one

Conditions

Conditions	Yield
With chlorine at -10℃; for 5h; Temperature; Saturated gas;	99.3%
With sulfuryl dichloride at 5 - 10℃; for 3h;	99.1%
With chlorine In dichloromethane at -10℃; for 5h; Temperature; Reagent/catalyst; Flow reactor;	99%

: 517-23-7
3-acetyl-2-oxo-4,5-dihydrofuran

: 135366-64-2
α-acetyl-α-hydroxy-γ-butyrolactone

Conditions

Conditions	Yield
With 3,3-dimethyldioxirane; nickel diacetate In water; acetone for 3.5h; Ambient temperature;	99%
With 3,3-dimethyldioxirane In acetone at 20℃; for 72h;	98%
With samarium (III) iodide; iodine In tetrahydrofuran; water at 25℃; for 12h; Catalytic behavior; Green chemistry;	95%

: 517-23-7
3-acetyl-2-oxo-4,5-dihydrofuran

: 78-94-4
methyl vinyl ketone

: 58623-81-7, 74627-02-4, 176101-57-8
3-acetyl-3-(3-oxobutyl)-4,5-dihydrofuran-2(3H)-one

Conditions

Conditions	Yield
With silica gel In neat (no solvent) at 0 - 90℃; for 20h; Michael Addition;	99%
NDEAP grafted on silica In water at 80℃; for 0.233333h; Michael addition; microwave irradiation;	84%
With iron(III) chloride In dichloromethane at 20℃; Michael reaction;	36%

: 517-23-7
3-acetyl-2-oxo-4,5-dihydrofuran

: 100-46-9
benzylamine

: 2-<1-(N-benzylamino)ethylidene>butyrolactone

Conditions

Conditions	Yield
With silica gel at 20℃; for 2h;	99%
With β‐cyclodextrin In water at 20℃; for 1.5h; chemospecific reaction;	96%
With cerium(III) chloride; tetrabutylammomium bromide at 20℃; for 0.0833333h;	95%

: 517-23-7
3-acetyl-2-oxo-4,5-dihydrofuran

: 75-77-4
chloro-trimethyl-silane

: 3-[1-[(trimethylsilyl)oxy]ethylidenyl]-4,5-dihydrofuran-2-one

Conditions

Conditions	Yield
With lithium diisopropyl amide In tetrahydrofuran at -78 - 20℃;	99%
With triethylamine In benzene at 20℃; for 14h; Etherification;

: 517-23-7
3-acetyl-2-oxo-4,5-dihydrofuran

: 618-36-0
rac-methylbenzylamine

: (Z)-3-[1-(1-phenylethylamino)ethylidene]tetrahydro-2-furanone

Conditions

Conditions	Yield
With silica gel at 20℃; for 3.5h;	99%
at 23℃; for 4h;	89%

: 517-23-7
3-acetyl-2-oxo-4,5-dihydrofuran

: 74-89-5
methylamine

: 3-[1-Methylamino-eth-(Z)-ylidene]-dihydro-furan-2-one

Conditions

Conditions	Yield
With silica gel at 20℃; for 4h;	99%

: 517-23-7
3-acetyl-2-oxo-4,5-dihydrofuran

: 2-(1-aminoethylidene)butyrolactone

Conditions

Conditions	Yield
With ammonia; silica gel at 20℃; for 5h;	99%
With ammonium acetate; tetraethoxy orthosilicate In ethanol Heating;	98%

: 517-23-7
3-acetyl-2-oxo-4,5-dihydrofuran

: C6H7BF2O3

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate In toluene at 25℃; for 16h;	99%
With boron trifluoride diethyl etherate In toluene at 25℃; for 24h;	99%

: 517-23-7
3-acetyl-2-oxo-4,5-dihydrofuran

: 5153-67-3
nitrostyrene

: 3-acetyl-3-(-2-nitro-1-phenylethyl)dihydrofuran-2(3H)-one

Conditions

Conditions	Yield
With 1-[3,5-bis(trifluoromethyl)phenyl]-3-[(2S)-dimethylamino-(1S)-phenylpropyl]thiourea In diethyl ether at 0℃; for 17h; nitro-Michael reaction; enantioselective reaction;	99%
With 3-((3,5-bis(trifluoromethyl)benzyl)amino)-4-((2-(dimethylamino)ethyl)-amino)cyclobut-3-ene-1,2-dione In toluene at 25℃; for 24h; Michael Addition; Inert atmosphere;	87%
(3ξ,8α,9R)-cinchonan-6',9-diol In tetrahydrofuran at 20℃; for 0.5h; Product distribution / selectivity; Michael Condensation;
With 1,4-diaza-bicyclo[2.2.2]octane In dichloromethane at 20℃; Michael Addition;
With 1,4-diaza-bicyclo[2.2.2]octane In neat (no solvent) at 20℃; Michael Addition;

: 517-23-7
3-acetyl-2-oxo-4,5-dihydrofuran

: 95-54-5
1,2-diamino-benzene

: (Z)-3-[1-(2-aminophenylamino)ethylidene]dihydrofuran-2(3H)-one

Conditions

Conditions	Yield
In ethanol at 20℃; for 24h;	99%

: 517-23-7
3-acetyl-2-oxo-4,5-dihydrofuran

: C6H7ClO3*ClH

Conditions

Conditions	Yield
With chlorine at 25 - 45℃; under 760.051 - 1520.1 Torr; for 2h; Temperature; Pressure; Concentration;	98.6%

: 517-23-7
3-acetyl-2-oxo-4,5-dihydrofuran

: 101561-12-0
C12H12N2O3

: 7-Benzoylamino-6-hydroxy-6,8-dimethyl-1-oxo-2-oxa-7-aza-spiro[4.4]non-8-ene-9-carboxylic acid methyl ester

Conditions

Conditions	Yield
In tetrahydrofuran for 0.1h; Ambient temperature;	98%

: 517-23-7
3-acetyl-2-oxo-4,5-dihydrofuran

: 155321-91-8
(-)-syn-(3R,1'R)-α-(hydroxyethyl)-γ-butyrolactone

Conditions

Conditions	Yield
In N,N-dimethyl-formamide under 375030 Torr; Ambient temperature; Saccharomyces cerevisiae ML29;	98%
In N,N-dimethyl-formamide at 26℃; for 24h; Yarrowia lipolytica Y5;	95%
With nicotinic acid; ammonium sulfate; potassium dihydrogenphosphate; 5-hydroxy-6-methyl-3,4-pyridinedimethanol; D-glucose; D-myo-inositol; vitamin B1; boric acid; calcium (R)-pantothenate; magnesium sulfate; copper(II) sulfate; zinc(II) sulfate; potassium iodide; calcium chloride; manganese(ll) chloride; iron(II) chloride; biotin In ethanol; water at 29℃; for 96h; Yarrowia lipolytica PFL9CE;	69%

: 517-23-7
3-acetyl-2-oxo-4,5-dihydrofuran

: 292638-85-8
acrylic acid methyl ester

: 280568-02-7
3-acetyl-2-oxotetrahydrofuran-3-propanoic acid methyl ester

Conditions

Conditions	Yield
With polystyrene supported P1 iminophosphorane P-BEMP In tetrahydrofuran at 20℃; for 3h; Michael addition;	98%
With sodium hydride In tert-butyl alcohol at 35℃; for 4h; Michael addition;	96%
With 1,4-diaza-bicyclo[2.2.2]octane; water at 20℃; Michael addition;	95%

: 517-23-7
3-acetyl-2-oxo-4,5-dihydrofuran

: 106-47-8
4-chloro-aniline

: 64620-30-0
3-[(Z)-1-(4-chloro-anilino)-ethylidene]-dihydro-furan-2-one

Conditions

Conditions	Yield
With cerium(III) chloride; tetrabutylammomium bromide at 20℃; for 0.0833333h;	98%
With β‐cyclodextrin In water at 20℃; for 0.333333h; chemospecific reaction;	95%
With tris(trifluoroacetato)bismuth(III); tetrabutylammomium bromide at 20℃; for 0.0833333h;	93%
cerium(III) chloride In water at 20℃; for 0.0833333h;	88%

: 517-23-7
3-acetyl-2-oxo-4,5-dihydrofuran

: 101-80-4
4,4'-oxydiphenylene diamine

: C24H24N2O5

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In toluene for 12h; Heating;	98%

: 517-23-7
3-acetyl-2-oxo-4,5-dihydrofuran

: 41601-44-9
3-amino-4,6-dimethylpyrazolo[3,4-b]pyridine

: 1220997-01-2
3-(2-hydroxyethyl)-2,8,10-trimethylpyrido[2',3':3,4]pyrazolo[1,5-a]pyrimidin-4-ol

Conditions

Conditions	Yield
In diphenylether at 220 - 225℃; for 0.25h;	98%

: 673-32-5
1-Phenylprop-1-yne

: 517-23-7
3-acetyl-2-oxo-4,5-dihydrofuran

A: 3-acetyl-3-(1-phenylallyl)dihydrofuran-2(3H)-one

B: α-acetyl-α-(trans-cinnamyl)-γ-butyrolactone

Conditions

Conditions	Yield
With chloro(1,5-cyclooctadiene)rhodium(I) dimer; bis[2-(diphenylphosphino)phenyl] ether; ytterbium(III) triflate In 1,2-dichloro-ethane at 70℃; for 48h; Schlenk technique; Inert atmosphere; Glovebox; Sealed tube; diastereoselective reaction;	A 98% B n/a

...Expand

: 517-23-7
3-acetyl-2-oxo-4,5-dihydrofuran

: 765-43-5
Cyclopropyl methyl ketone

Conditions

Conditions	Yield
With sodium iodide at 192℃; under 4500.45 Torr; Reagent/catalyst; Temperature; Pressure;	97.12%
Stage #1: 3-acetyl-2-oxo-4,5-dihydrofuran With hydrogenchloride In water at 100℃; for 2h; Stage #2: With sodium hydroxide In water at 80 - 100℃; for 2h;	90.2%
With 1-methyl-pyrrolidin-2-one; sodium iodide at 170℃; for 3h;	59%

: 517-23-7
3-acetyl-2-oxo-4,5-dihydrofuran

: 4519-46-4
methyl 2-bromoacrylate

: methyl 1-methylene-6-oxo-2,7-dioxaspiro[4,4]nonane-3-carboxylate

Conditions

Conditions	Yield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In tetrahydrofuran Ambient temperature;	96%
With 1,8-diazabicyclo[5.4.0]undec-7-ene In tetrahydrofuran at -78 - -50℃; for 2h; domino Michael-O-alkylation;	96%

: 517-23-7
3-acetyl-2-oxo-4,5-dihydrofuran

: 106-49-0
p-toluidine

: 64620-32-2
3-[(Z)-1-(4-toluidino)ethylidene]-dihydro-furan-2-one

Conditions

Conditions	Yield
With β‐cyclodextrin In water at 20℃; for 1h; chemospecific reaction;	96%
ammonium cerium(IV) nitrate at 20℃; for 1.16667h;	95%
zirconium(IV) chloride at 20℃; for 0.5h;	92%

: 517-23-7
3-acetyl-2-oxo-4,5-dihydrofuran

: 141-43-5
ethanolamine

: 3-[1-(2-hydroxyethylamino)ethylidene]tetrahydrofuran-2-one

Conditions

Conditions	Yield
With tris(trifluoroacetato)bismuth(III); tetrabutylammomium bromide at 20℃; for 0.166667h;	96%
With β‐cyclodextrin In water at 20℃; for 1.33333h; chemospecific reaction;	95%
With tris(trifluoroacetato)bismuth(III) In water at 20℃; for 10h;	93%
With cerium(III) chloride; tetrabutylammomium bromide at 20℃; for 0.0833333h;	92%
cerium(III) chloride In water at 20℃; for 0.166667h;	85%

: 517-23-7
3-acetyl-2-oxo-4,5-dihydrofuran

: 65185-68-4
(E)-2-bromo-β-nitrostyrene

: 3-acetyl-3-(1-(2-bromophenyl)-2-nitroethyl)dihydrofuran-2(3H)-one

Conditions

Conditions	Yield
With 3-((3,5-bis(trifluoromethyl)benzyl)amino)-4-((2-(dimethylamino)ethyl)-amino)cyclobut-3-ene-1,2-dione In toluene at 25℃; for 24h; Michael Addition; Inert atmosphere;	96%

: 517-23-7
3-acetyl-2-oxo-4,5-dihydrofuran

: 74-88-4
methyl iodide

: 1123-19-9, 112607-28-0, 112607-29-1
3-acetyl-3-methyl-dihydro-furan-2-one

Conditions

Conditions	Yield
With potassium carbonate In acetone at 50℃; for 16h; Large scale;	95%
Stage #1: 3-acetyl-2-oxo-4,5-dihydrofuran With sodium methylate In benzene Stage #2: methyl iodide Further stages.;	83%
With potassium carbonate In acetone	80%

2-Acetylbutyrolactone Specification

The 2-Acetylbutyrolactone, with the CAS registry number 517-23-7, is also known as 3-Acetyldihydro-2(3H)-furanone. It belongs to the product categories of Ketone; Furan & Benzofuran; Carbonyl Compounds; Lactones; Organic Building Blocks; Heterocycles; Intermediates & Fine Chemicals; Pharmaceuticals. Its EINECS registry number is 208-235-2. This chemical's molecular formula is C₆H₈O₃ and molecular weight is 128.13. What's more, its IUPAC name is called 3-Acetyloxolan-2-one. It should be stored in a cool, dry and sealed place.

Physical properties about 2-Acetylbutyrolactone are: (1)ACD/LogP: -1.217; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -1.22; (4)ACD/LogD (pH 7.4): -1.22; (5)ACD/BCF (pH 5.5): 1.00; (6)ACD/BCF (pH 7.4): 1.00; (7)ACD/KOC (pH 5.5): 5.19; (8)ACD/KOC (pH 7.4): 5.19; (9)#H bond acceptors: 3; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 1; (12)Polar Surface Area: 43.37 Å²; (13)Index of Refraction: 1.459; (14)Molar Refractivity: 29.388 cm³; (15)Molar Volume: 107.507 cm³; (16)Polarizability: 11.65×10^-24cm³; (17)Surface Tension: 39.39 dyne/cm; (18)Density: 1.192 g/cm³; (19)Flash Point: 128.244 °C; (20)Enthalpy of Vaporization: 49.045 kJ/mol; (21)Boiling Point: 253.078 °C at 760 mmHg; (22)Vapour Pressure: 0.019 mmHg at 25 °C.

Preparation of 2-Acetylbutyrolactone: this chemical can be prepared by oxirane with acetoacetic acid methyl ester. This reaction needs reagent sodium hydroxide and solvents H₂O, ethanol at temperature of -5 – 0 °C. The reaction time is 50 hours. The yield is 78 %.

2-Acetylbutyrolactone can be prepared by oxirane with acetoacetic acid methyl ester.

Uses of 2-Acetylbutyrolactone: (1) it is an important intermediate to synthesize vitamin B,3,4 - disubstituted pyridine and 5-(β-hydroxyethyl) -4- methyl-thiazole. (2) it is used to produce other chemicals. For example, it can react with methanol to get 2-methyl-4,5-dihydro-furan-3-carboxylic acid methyl ester. The reaction occurs with reagent hydrogen chloride and other condition of heating for 4 days. The yield is 19 %.

2-Acetylbutyrolactone can react with methanol to get 2-methyl-4,5-dihydro-furan-3-carboxylic acid methyl ester.

When you are dealing with this chemical, you should be very careful. This chemical is inflammation to the skin, eyes and respiratory system or other mucous membranes. Therefore, you should wear suitable protective clothing, gloves and eye/face protection. In case of contacting with eyes, you should rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1) SMILES: O=C1OCCC1C(=O)C
(2) InChI: InChI=1S/C6H8O3/c1-4(7)5-2-3-9-6(5)8/h5H,2-3H2,1H3
(3) InChIKey: OMQHDIHZSDEIFH-UHFFFAOYSA-N

Product Name

2-Acetylbutyrolactone

Synthetic route

2-Acetylbutyrolactone Specification

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